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RUP was administered in the presence and absence of OIR. Thirty-two adult Wistar albino female rats were randomly arranged into four groups: Sham, RUP (6\u00a0mg\/kg\/day) for 14 days, OIR and OIR\u2009+\u2009RUP groups.The results demonstrated that OIR significantly lowered serum anti-mullerian hormone level and ovarian total antioxidant capacity. Besides, a significant elevation in serum follicle stimulating hormone, lutenizing hormone, ovarian malondialdehyde level, hypoxia-inducible factor-1(HIF-1\u03b1), platelet activating factor (PAF), tumor necrosis factor-alpha (TNF-\u03b1), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-\u03baB) and interleukin 1beta (IL-1\u03b2) levels along with an evident increase in ovarian vascular endothelial growth factor (VEGF) and caspase-3 immunoexpression. While, OIR\u2009+\u2009RUP pretreated group showed a reversal in OIR damaging effects in a significant manner in all the aforementioned parameters. Based on these findings; RUP has powerful anti-IR actions by lowering oxidative stress, inflammation, and apoptosis via modulation of the PAF\/ NF-\u03baB\/TNF-\u03b1\/ IL-1\u03b2; HIF-1\u03b1\/ VEGF \/ Caspase 3 signaling pathways.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s00210-025-04567-0","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T03:32:20Z","timestamp":1757043140000},"page":"2607-2618","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Repurposing rupatadine to attenuate ovarian ischemia reperfusion in rats through modulation of PAF\/NF-\u03baB\/TNF-\u03b1\/IL-1\u03b2; HIF-1\u03b1\/VEGF\/Caspase 3 signaling pathways"],"prefix":"10.1007","volume":"399","author":[{"given":"Hanaa Mohamed","family":"Khalaf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara M.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyaa Abdelfattah","family":"Abdelmonaem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabeh Khairy","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelaleem Abdelnour","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AbdelHamid Sayed AboBakr","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Adel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba Reda","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba S.","family":"Kamel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6511-1797","authenticated-orcid":false,"given":"Walaa Yehia","family":"Abdelzaher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"key":"4567_CR1","doi-asserted-by":"publisher","first-page":"117086","DOI":"10.1016\/j.taap.2024.117086","volume":"492","author":"AM Abdel-Aziz","year":"2024","unstructured":"Abdel-Aziz AM, Abdelmonaem AA, Thabit DM, Marey H, Ahmed SM (2024) Protective effect of rupatadine on testicular ischemia\/reperfusion injury in rats: Modulation of IL-6\/STAT3, Akt\/ mTOR signaling pathways. 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