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Immune homeostasis during II\/R has a major role in controlling its progression. Thus, finding additive medical treatment besides the surgical one becomes an urgent need to keep the tissue. So that, we aimed to evaluate the possible ameliorative effect of diacerein (DIA) on II\/R-induced injury in juvenile rats. Forty juvenile rats of Wistar albino species were randomly allocated into four different groups: sham group, DIA given group, II\/R group via clamping superior mesenteric artery, DIA-treated group (50\u00a0mg\/kg) with induction of II\/R. Data of current model revealed a significant elevation of the measured cardiac enzymes, cleaved caspase-3, and nuclear factor kappa \u03b2 (NF-\u03baB) in the untreated ischemic group with disturbed oxidative stress parameters, accompanied with dysregulation of inflammasome\/caspase-1\/IL-1\u03b2 and Wnt\/\u03b2-catenin signaling cascades. Fortunately, upon co-administration of DIA, there is a significant decrease of cardiac enzymes, cleaved caspase-3, and NF-\u03baB with normalization of oxidative stress parameters and regulation of inflammasome\/caspase-1\/IL-1\u03b2 and Wnt\/\u03b2-catenin pathways confirmed by marked mitigation of the histopathological changes. This effect of DIA is greatly attributed to its pharmacological properties including IL-1\u03b2 antagonist effect, anti-oxidant, anti-apoptotic, and anti-inflammatory properties. Thus, DIA could be considered as an adjuvant future medical therapy for those cases of II\/R.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s00210-025-04581-2","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T08:41:28Z","timestamp":1757925688000},"page":"2855-2870","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Amelioration of intestinal ischemia reperfusion injury by diacerein via regulation of inflammasome\/caspase-1\/IL-1\u03b2 and Wnt\/\u03b2-catenin pathways in juvenile rats"],"prefix":"10.1007","volume":"399","author":[{"given":"Marwa Monier Mahmoud","family":"Refaie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada Amgad Mohamed Abdel","family":"Majeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayed","family":"Shehata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5998-9739","authenticated-orcid":false,"given":"Asmaa A.","family":"Muhammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma M.","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda S.","family":"Sherkawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma F.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Rabie","family":"Saad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mousa","family":"Mohsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shereen Mohammed Mohammed","family":"Elsaghir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enas","family":"Fathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia N.","family":"Beshay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"4581_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s11011-024-01457-x","volume":"40","author":"NA Abd Elrazik","year":"2024","unstructured":"Abd Elrazik NA, Abd El Salam ASG (2024) Diacerein ameliorates thioacetamide-induced hepatic encephalopathy in rats via modulation of TLR4\/AQP4\/MMP-9 axis. 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