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In this study, we investigated the antiemetic efficacy of LIN using both in vivo and in silico approaches. Emesis was induced in chicks via oral administration of copper sulfate pentahydrate (50\u00a0mg\/kg), and LIN was tested at doses of 25, 50, and 100\u00a0mg\/kg. Its effects were compared against the standard antiemetics domperidone (DOM, 7\u00a0mg\/kg) and ondansetron (OND, 5\u00a0mg\/kg). Results demonstrated that LIN at 100\u00a0mg\/kg significantly prolonged the emetic latency and reduced the number of retches. Notably, co-administration of LIN (50\u00a0mg\/kg) with DOM significantly (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) produced the most potent effect, yielding the highest latency and lowest number of retches, reflecting a synergistic interaction. Molecular docking studies revealed a strong binding affinity of LIN to the dopamine D2 receptor (\u2212\u20096.4\u00a0kcal\/mol) and moderate binding to the 5-HT3 receptor (\u2212\u20095.3\u00a0kcal\/mol), suggesting involvement of both dopaminergic and serotonergic mechanisms. These findings collectively indicate that LIN possesses significant antiemetic activity and may offer a plant-derived alternative for emesis control.\n                  <\/jats:p>","DOI":"10.1007\/s00210-025-04631-9","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:08:44Z","timestamp":1760951324000},"page":"4401-4411","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Linalool exerts antiemetic effects via dopaminergic and serotonergic pathways: Evidence from chick model and molecular docking"],"prefix":"10.1007","volume":"399","author":[{"given":"Abdullah Al","family":"Fahmi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija","family":"Akter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imam Hossen","family":"Rakib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakib","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali G.","family":"Alkhathami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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