{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:44:57Z","timestamp":1789753497112,"version":"4.0.1"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Shanxi Key Laboratory of Integrated Traditional Chinese and Western Medicine in Reproductive Medicine","award":["zyyyjs2024017"],"award-info":[{"award-number":["zyyyjs2024017"]}]},{"name":"the Shanxi Traditional Chinese Medicine Innovation Project: Formulation Development of Shuqiong Zhuyun Decoction for the Treatment of PCOS-related Infertility","award":["2025kjzy011"],"award-info":[{"award-number":["2025kjzy011"]}]},{"name":"the Central Government Guiding Local Science and Technology Development Fund Project","award":["YDZJSX2022A069"],"award-info":[{"award-number":["YDZJSX2022A069"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s00210-025-04667-x","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:53:18Z","timestamp":1760003598000},"page":"3819-3841","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Systematic investigation of the potential multi-target pharmacological mechanisms of Astragaloside IV in polycystic ovary syndrome via network pharmacology and in vivo\/in vitro experiments"],"prefix":"10.1007","volume":"399","author":[{"given":"Ying","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianrong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"4667_CR1","doi-asserted-by":"publisher","first-page":"118003","DOI":"10.1016\/j.lfs.2020.1180031.27cm","volume":"256","author":"NZ Abuelezz","year":"2020","unstructured":"Abuelezz NZ, Shabana ME, Abdel-Mageed HM et al (2020) Nanocurcumin alleviates insulin resistance and pancreatic deficits in polycystic ovary syndrome rats: insights on PI3K\/AkT\/mTOR and TNF-\u03b1 modulations. Life Sci 256:118003. https:\/\/doi.org\/10.1016\/j.lfs.2020.1180031.27cm","journal-title":"Life Sci"},{"key":"4667_CR2","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1093\/advances\/nmab1411.27cm","volume":"13","author":"S Alesi","year":"2022","unstructured":"Alesi S, Ee C, Moran LJ et al (2022) Nutritional supplements and complementary therapies in polycystic ovary syndrome. Adv Nutr 13:1243\u20131266. https:\/\/doi.org\/10.1093\/advances\/nmab1411.27cm","journal-title":"Adv Nutr"},{"key":"4667_CR3","doi-asserted-by":"publisher","first-page":"9739","DOI":"10.3390\/ijms212497391.27cm","volume":"21","author":"GA Cabral-Pacheco","year":"2020","unstructured":"Cabral-Pacheco GA, Garza-Veloz I, Castruita-De la Rosa C et al (2020) The roles of matrix metalloproteinases and their inhibitors in human diseases. Int J Mol Sci 21:9739. https:\/\/doi.org\/10.3390\/ijms212497391.27cm","journal-title":"Int J Mol Sci"},{"key":"4667_CR4","doi-asserted-by":"publisher","first-page":"156892","DOI":"10.1016\/j.phymed.2025.1568921.27cm","volume":"143","author":"G Chen","year":"2025","unstructured":"Chen G, Gou B, Du Y et al (2025) Predicting the molecular mechanism of ginger targeting PRMT1\/BTG2 axis to inhibit gastric cancer based on WGCNA and machine algorithms. Phytomedicine 143:156892. https:\/\/doi.org\/10.1016\/j.phymed.2025.1568921.27cm","journal-title":"Phytomedicine"},{"key":"4667_CR5","doi-asserted-by":"publisher","first-page":"3106","DOI":"10.1038\/s44319-025-00463-z1.27cm","volume":"26","author":"RJ Conrad","year":"2025","unstructured":"Conrad RJ, Mondo JA, Wang ML et al (2025) NRF2 supports non-small cell lung cancer growth independently of CBP\/p300-enhanced glutathione synthesis. EMBO Rep 26:3106\u20133137. https:\/\/doi.org\/10.1038\/s44319-025-00463-z1.27cm","journal-title":"EMBO Rep"},{"key":"4667_CR6","doi-asserted-by":"publisher","unstructured":"Das S, Dewanjee S, Dua TK et al (2019) Carnosic acid attenuates cadmium induced nephrotoxicity by inhibiting oxidative stress, promoting Nrf2\/HO-1 signalling and impairing TGF-\u03b21\/Smad\/collagen IV signalling. Molecules 24 https:\/\/doi.org\/10.3390\/molecules242241761.27cm","DOI":"10.3390\/molecules242241761.27cm"},{"key":"4667_CR7","doi-asserted-by":"publisher","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","volume":"4","author":"G Dennis Jr","year":"2003","unstructured":"Dennis G Jr, Sherman BT, Hosack DA et al (2003) DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 4:P3. https:\/\/doi.org\/10.1186\/gb-2003-4-5-p3","journal-title":"Genome Biol"},{"key":"4667_CR8","doi-asserted-by":"publisher","first-page":"3891","DOI":"10.1021\/acs.jcim.1c002031.27cm","volume":"61","author":"J Eberhardt","year":"2021","unstructured":"Eberhardt J, Santos-Martins D, Tillack AF et al (2021) Autodock vina 1.2.0: new docking methods, expanded force field, and python bindings. J Chem Inf Model 61:3891\u20133898. https:\/\/doi.org\/10.1021\/acs.jcim.1c002031.27cm","journal-title":"J Chem Inf Model"},{"key":"4667_CR9","doi-asserted-by":"publisher","unstructured":"Ge BK, Hu GM, Chen R et al (2022) MSClustering: a cytoscape tool for multi-level clustering of biological networks. Int J Mol Sci 23. https:\/\/doi.org\/10.3390\/ijms2322142401.27cm","DOI":"10.3390\/ijms2322142401.27cm"},{"key":"4667_CR10","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3390\/biom120100821.27cm","volume":"12","author":"S Ghafouri-Fard","year":"2022","unstructured":"Ghafouri-Fard S, Shoorei H, Bahroudi Z et al (2022) Nrf2-related therapeutic effects of curcumin in different disorders. Biomolecules 12:82. https:\/\/doi.org\/10.3390\/biom120100821.27cm","journal-title":"Biomolecules"},{"key":"4667_CR11","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/j.fertnstert.2022.03.0091.27cm","volume":"117","author":"C Guan","year":"2022","unstructured":"Guan C, Zahid S, Minhas AS et al (2022) Polycystic ovary syndrome: a \u201crisk-enhancing\u201d factor for cardiovascular disease. Fertil Steril 117:924\u2013935. https:\/\/doi.org\/10.1016\/j.fertnstert.2022.03.0091.27cm","journal-title":"Fertil Steril"},{"key":"4667_CR12","doi-asserted-by":"publisher","first-page":"156032","DOI":"10.1016\/j.phymed.2024.1560321.27cm","volume":"135","author":"J Hao","year":"2024","unstructured":"Hao J, Hu R, Zhao J et al (2024) Metabolomics combined with network pharmacology reveals the protective effect of astragaloside IV on alcoholic liver disease. Phytomedicine 135:156032. https:\/\/doi.org\/10.1016\/j.phymed.2024.1560321.27cm","journal-title":"Phytomedicine"},{"key":"4667_CR13","doi-asserted-by":"publisher","first-page":"1102581","DOI":"10.3389\/fphar.2023.11025811.27cm","volume":"14","author":"Q He","year":"2023","unstructured":"He Q, Liu C, Wang X et al (2023) Exploring the mechanism of curcumin in the treatment of colon cancer based on network pharmacology and molecular docking. Front Pharmacol 14:1102581. https:\/\/doi.org\/10.3389\/fphar.2023.11025811.27cm","journal-title":"Front Pharmacol"},{"key":"4667_CR14","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/s41574-024-01057-w1.27cm","volume":"21","author":"N Helvaci","year":"2025","unstructured":"Helvaci N, Yildiz BO (2025) Polycystic ovary syndrome as a metabolic disease. Nat Rev Endocrinol 21:230\u2013244. https:\/\/doi.org\/10.1038\/s41574-024-01057-w1.27cm","journal-title":"Nat Rev Endocrinol"},{"key":"4667_CR15","doi-asserted-by":"publisher","first-page":"117025","DOI":"10.1016\/j.jep.2023.1170251.27cm","volume":"318","author":"W Hu","year":"2024","unstructured":"Hu W, Xie N, Pan M et al (2024) Chinese herbal medicine alleviates autophagy and apoptosis in ovarian granulosa cells induced by testosterone through PI3K\/AKT1\/FOXO1 pathway. J Ethnopharmacol 318:117025. https:\/\/doi.org\/10.1016\/j.jep.2023.1170251.27cm","journal-title":"J Ethnopharmacol"},{"key":"4667_CR16","doi-asserted-by":"publisher","first-page":"167904","DOI":"10.1016\/j.scitotenv.2023.1679041.27cm","volume":"905","author":"S Huang","year":"2023","unstructured":"Huang S (2023) Efficient analysis of toxicity and mechanisms of environmental pollutants with network toxicology and molecular docking strategy: acetyl tributyl citrate as an example. Sci Total Environ 905:167904. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.1679041.27cm","journal-title":"Sci Total Environ"},{"key":"4667_CR17","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1186\/s12967-023-04333-x1.27cm","volume":"21","author":"X Huang","year":"2023","unstructured":"Huang X, Liu Y, Qian C et al (2023) CHSY3 promotes proliferation and migration in gastric cancer and is associated with immune infiltration. J Transl Med 21:474. https:\/\/doi.org\/10.1186\/s12967-023-04333-x1.27cm","journal-title":"J Transl Med"},{"key":"4667_CR18","doi-asserted-by":"publisher","first-page":"5488","DOI":"10.3390\/ijms261254881.27cm","volume":"26","author":"V Lambadiari","year":"2025","unstructured":"Lambadiari V, Pililis S, Lampsas S et al (2025) Endothelial function and matrix metalloproteinase 9 (MMP9) in women with polycystic ovary syndrome (PCOS). Int J Mol Sci 26:5488. https:\/\/doi.org\/10.3390\/ijms261254881.27cm","journal-title":"Int J Mol Sci"},{"key":"4667_CR19","doi-asserted-by":"publisher","first-page":"10422","DOI":"10.1038\/s41467-024-54920-91.27cm","volume":"15","author":"CJ Lee","year":"2024","unstructured":"Lee CJ, Jang TY, Jeon SE et al (2024) The dysadherin\/MMP9 axis modifies the extracellular matrix to accelerate colorectal cancer progression. Nat Commun 15:10422. https:\/\/doi.org\/10.1038\/s41467-024-54920-91.27cm","journal-title":"Nat Commun"},{"key":"4667_CR20","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1082497","volume":"2019","author":"B Leng","year":"2019","unstructured":"Leng B, Zhang Y, Liu X et al (2019) Astragaloside IV suppresses high glucose-induced NLRP3 inflammasome activation by inhibiting TLR4\/NF-\u03baB and CaSR. Mediators Inflamm 2019:1082497. https:\/\/doi.org\/10.1155\/2019\/1082497","journal-title":"Mediators Inflamm"},{"key":"4667_CR21","doi-asserted-by":"publisher","first-page":"109387","DOI":"10.1016\/j.biopha.2019.1093871.27cm","volume":"119","author":"N Li","year":"2019","unstructured":"Li N, Feng F, Wu K et al (2019) Inhibitory effects of astragaloside IV on silica-induced pulmonary fibrosis via inactivating TGF-\u03b21\/Smad3 signaling. Biomed Pharmacother 119:109387. https:\/\/doi.org\/10.1016\/j.biopha.2019.1093871.27cm","journal-title":"Biomed Pharmacother"},{"key":"4667_CR22","doi-asserted-by":"publisher","first-page":"122597","DOI":"10.1016\/j.carbpol.2024.1225971.27cm","volume":"345","author":"H Li","year":"2024","unstructured":"Li H, Hou Y, Jia S et al (2024) Oxidized paramylon self-assembled nanoparticles loaded with fucoxanthin attenuate insulin resistance in HpeG2 cells. Carbohydr Polym 345:122597. https:\/\/doi.org\/10.1016\/j.carbpol.2024.1225971.27cm","journal-title":"Carbohydr Polym"},{"key":"4667_CR23","doi-asserted-by":"publisher","unstructured":"Liang Y, Chen B, Liang D et al (2023) Pharmacological effects of Astragaloside IV: a review. Molecules 28 https:\/\/doi.org\/10.3390\/molecules281661181.27cm","DOI":"10.3390\/molecules281661181.27cm"},{"key":"4667_CR24","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1093\/humrep\/deaa3711.27cm","volume":"36","author":"J Liu","year":"2021","unstructured":"Liu J, Wu Q, Hao Y et al (2021) Measuring the global disease burden of polycystic ovary syndrome in 194 countries: Global Burden of Disease Study 2017. Hum Reprod 36:1108\u20131119. https:\/\/doi.org\/10.1093\/humrep\/deaa3711.27cm","journal-title":"Hum Reprod"},{"key":"4667_CR25","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.cell.2006.04.0211.27cm","volume":"125","author":"DM Lonard","year":"2006","unstructured":"Lonard DM, O\u2019Malley BW (2006) The expanding cosmos of nuclear receptor coactivators. Cell 125:411\u2013414. https:\/\/doi.org\/10.1016\/j.cell.2006.04.0211.27cm","journal-title":"Cell"},{"key":"4667_CR26","doi-asserted-by":"publisher","first-page":"e2300734","DOI":"10.1002\/mnfr.2023007341.27cm","volume":"68","author":"X Lyu","year":"2024","unstructured":"Lyu X, Zhang TT, Ye Z et al (2024) Astragaloside IV mitigated diabetic nephropathy by restructuring intestinal microflora and ferroptosis. Mol Nutr Food Res 68:e2300734. https:\/\/doi.org\/10.1002\/mnfr.2023007341.27cm","journal-title":"Mol Nutr Food Res"},{"key":"4667_CR27","doi-asserted-by":"publisher","first-page":"18934","DOI":"10.1074\/jbc.M1011032001.27cm","volume":"276","author":"LV Madrid","year":"2001","unstructured":"Madrid LV, Mayo MW, Reuther JY et al (2001) Akt stimulates the transactivation potential of the RelA\/p65 subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38. J Biol Chem 276:18934\u201318940. https:\/\/doi.org\/10.1074\/jbc.M1011032001.27cm","journal-title":"J Biol Chem"},{"key":"4667_CR28","doi-asserted-by":"publisher","unstructured":"Mahmud Z, Gomes AR, Lee HJ et al (2019) EP300 and SIRT1\/6 Co-regulate lapatinib sensitivity via modulating FOXO3-acetylation and activity in breast cancer. Cancers (Basel) 11.https:\/\/doi.org\/10.3390\/cancers110810671.27cm","DOI":"10.3390\/cancers110810671.27cm"},{"key":"4667_CR29","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.molmed.2016.05.0021.27cm","volume":"22","author":"S Menegon","year":"2016","unstructured":"Menegon S, Columbano A, Giordano S (2016) The dual roles of NRF2 in cancer. Trends Mol Med 22:578\u2013593. https:\/\/doi.org\/10.1016\/j.molmed.2016.05.0021.27cm","journal-title":"Trends Mol Med"},{"key":"4667_CR30","doi-asserted-by":"publisher","first-page":"e2404966","DOI":"10.1002\/adhm.2024049661.27cm","volume":"14","author":"H Meng","year":"2025","unstructured":"Meng H, Su J, Shen Q et al (2025) A smart MMP-9-responsive hydrogel releasing M2 macrophage-derived exosomes for diabetic wound healing. Adv Healthc Mater 14:e2404966. https:\/\/doi.org\/10.1002\/adhm.2024049661.27cm","journal-title":"Adv Healthc Mater"},{"key":"4667_CR31","doi-asserted-by":"publisher","first-page":"1324429","DOI":"10.3389\/fendo.2023.13244291.27cm","volume":"14","author":"M Orisaka","year":"2023","unstructured":"Orisaka M, Mizutani T, Miyazaki Y et al (2023) Chronic low-grade inflammation and ovarian dysfunction in women with polycystic ovarian syndrome, endometriosis, and aging. Front Endocrinol (Lausanne) 14:1324429. https:\/\/doi.org\/10.3389\/fendo.2023.13244291.27cm","journal-title":"Front Endocrinol (Lausanne)"},{"key":"4667_CR32","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1677\/joe-09-00611.27cm","volume":"203","author":"B Piotrkowski","year":"2009","unstructured":"Piotrkowski B, Monz\u00f3n CM, Pagotto RM et al (2009) Effects of heme oxygenase isozymes on Leydig cells steroidogenesis. J Endocrinol 203:155\u2013165. https:\/\/doi.org\/10.1677\/joe-09-00611.27cm","journal-title":"J Endocrinol"},{"key":"4667_CR33","doi-asserted-by":"publisher","unstructured":"Rosignoli S, Paiardini A (2022) Boosting the full potential of PyMOL with structural biology plugins. Biomolecules 12. https:\/\/doi.org\/10.3390\/biom121217641.27cm","DOI":"10.3390\/biom121217641.27cm"},{"key":"4667_CR34","doi-asserted-by":"publisher","first-page":"4233","DOI":"10.1093\/bioinformatics\/btac4521.27cm","volume":"38","author":"S Rosignoli","year":"2022","unstructured":"Rosignoli S, Paiardini A (2022) Dockingpie: a consensus docking plugin for PyMOL. Bioinformatics 38:4233\u20134234. https:\/\/doi.org\/10.1093\/bioinformatics\/btac4521.27cm","journal-title":"Bioinformatics"},{"key":"4667_CR35","doi-asserted-by":"publisher","unstructured":"Sadeghi HM, Adeli I, Calina D et al (2022) Polycystic ovary syndrome: a comprehensive review of pathogenesis, management, and drug repurposing. Int J Mol Sci 23.https:\/\/doi.org\/10.3390\/ijms230205831.27cm","DOI":"10.3390\/ijms230205831.27cm"},{"key":"4667_CR36","doi-asserted-by":"publisher","unstructured":"Shang Y, Zhou H, Hu M et al (2020) Effect of diet on insulin resistance in polycystic ovary syndrome. J Clin Endocrinol Metab 105. https:\/\/doi.org\/10.1210\/clinem\/dgaa4251.27cm","DOI":"10.1210\/clinem\/dgaa4251.27cm"},{"key":"4667_CR37","doi-asserted-by":"publisher","first-page":"1419126","DOI":"10.3389\/fimmu.2024.14191261.27cm","volume":"15","author":"DM Song","year":"2024","unstructured":"Song DM, Shen T, Feng K et al (2024) LIG1 is a novel marker for bladder cancer prognosis: evidence based on experimental studies, machine learning and single-cell sequencing. Front Immunol 15:1419126. https:\/\/doi.org\/10.3389\/fimmu.2024.14191261.27cm","journal-title":"Front Immunol"},{"key":"4667_CR38","doi-asserted-by":"publisher","first-page":"135117","DOI":"10.1016\/j.ijbiomac.2024.1351171.27cm","volume":"279","author":"C Song","year":"2024","unstructured":"Song C, Wang L, Zhang F et al (2024) DUSP6 protein action and related hub genes prevention of sepsis-induced lung injury were screened by WGCNA and Venn. Int J Biol Macromol 279:135117. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.1351171.27cm","journal-title":"Int J Biol Macromol"},{"key":"4667_CR39","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41572-024-00511-31.27cm","volume":"10","author":"E Stener-Victorin","year":"2024","unstructured":"Stener-Victorin E, Teede H, Norman RJ et al (2024) Polycystic ovary syndrome. Nat Rev Dis Primers 10:27. https:\/\/doi.org\/10.1038\/s41572-024-00511-31.27cm","journal-title":"Nat Rev Dis Primers"},{"issue":"10","key":"4667_CR40","doi-asserted-by":"publisher","first-page":"2658","DOI":"10.1128\/mcb.01639-08","volume":"29","author":"Z Sun","year":"2009","unstructured":"Sun Z, Chin YE, Zhang DD (2009) Acetylation of Nrf2 by p300\/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response. Mol Cell Biol 29(10):2658\u20132672. https:\/\/doi.org\/10.1128\/mcb.01639-08","journal-title":"Mol Cell Biol"},{"key":"4667_CR41","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.cmet.2013.06.0161.27cm","volume":"18","author":"K Sun","year":"2013","unstructured":"Sun K, Tordjman J, Cl\u00e9ment K et al (2013) Fibrosis and adipose tissue dysfunction. Cell Metab 18:470\u2013477. https:\/\/doi.org\/10.1016\/j.cmet.2013.06.0161.27cm","journal-title":"Cell Metab"},{"key":"4667_CR42","doi-asserted-by":"publisher","first-page":"102852","DOI":"10.1016\/j.redox.2023.1028521.27cm","volume":"66","author":"YY Sun","year":"2023","unstructured":"Sun YY, Zhu HJ, Zhao RY et al (2023) Remote ischemic conditioning attenuates oxidative stress and inflammation via the Nrf2\/HO-1 pathway in MCAO mice. Redox Biol 66:102852. https:\/\/doi.org\/10.1016\/j.redox.2023.1028521.27cm","journal-title":"Redox Biol"},{"key":"4667_CR43","doi-asserted-by":"publisher","first-page":"D605","DOI":"10.1093\/nar\/gkaa10741.27cm","volume":"49","author":"D Szklarczyk","year":"2021","unstructured":"Szklarczyk D, Gable AL, Nastou KC et al (2021) The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets. Nucleic Acids Res 49:D605-d612. https:\/\/doi.org\/10.1093\/nar\/gkaa10741.27cm","journal-title":"Nucleic Acids Res"},{"key":"4667_CR44","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac10001.27cm","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk D, Kirsch R, Koutrouli M et al (2023) The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res 51:D638-d646. https:\/\/doi.org\/10.1093\/nar\/gkac10001.27cm","journal-title":"Nucleic Acids Res"},{"key":"4667_CR45","doi-asserted-by":"publisher","first-page":"G43","DOI":"10.1093\/ejendo\/lvad0961.27cm","volume":"189","author":"HJ Teede","year":"2023","unstructured":"Teede HJ, Tay CT, Laven JJE et al (2023) Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Eur J Endocrinol 189:G43-g64. https:\/\/doi.org\/10.1093\/ejendo\/lvad0961.27cm","journal-title":"Eur J Endocrinol"},{"key":"4667_CR46","doi-asserted-by":"publisher","first-page":"1091147","DOI":"10.3389\/fendo.2022.10911471.27cm","volume":"13","author":"C Tong","year":"2022","unstructured":"Tong C, Wu Y, Zhang L et al (2022) Insulin resistance, autophagy and apoptosis in patients with polycystic ovary syndrome: association with PI3K signaling pathway. Front Endocrinol (Lausanne) 13:1091147. https:\/\/doi.org\/10.3389\/fendo.2022.10911471.27cm","journal-title":"Front Endocrinol (Lausanne)"},{"key":"4667_CR47","doi-asserted-by":"publisher","first-page":"W310","DOI":"10.1093\/nar\/gkl2061.27cm","volume":"34","author":"A Tovchigrechko","year":"2006","unstructured":"Tovchigrechko A, Vakser IA (2006) GRAMM-X public web server for protein-protein docking. Nucleic Acids Res 34:W310-314. https:\/\/doi.org\/10.1093\/nar\/gkl2061.27cm","journal-title":"Nucleic Acids Res"},{"key":"4667_CR48","doi-asserted-by":"publisher","first-page":"774","DOI":"10.3390\/ijms260207741.27cm","volume":"26","author":"QA Tran","year":"2025","unstructured":"Tran QA, Tran GV, Velic S et al (2025) Effects of Astragaloside IV and formononetin on oxidative stress and mitochondrial biogenesis in hepatocytes. Int J Mol Sci 26:774. https:\/\/doi.org\/10.3390\/ijms260207741.27cm","journal-title":"Int J Mol Sci"},{"key":"4667_CR49","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1016\/s1097-2765(03)00391-51.27cm","volume":"12","author":"AE Wallberg","year":"2003","unstructured":"Wallberg AE, Yamamura S, Malik S et al (2003) Coordination of p300-mediated chromatin remodeling and TRAP\/mediator function through coactivator PGC-1alpha. Mol Cell 12:1137\u20131149. https:\/\/doi.org\/10.1016\/s1097-2765(03)00391-51.27cm","journal-title":"Mol Cell"},{"key":"4667_CR50","doi-asserted-by":"publisher","first-page":"109729","DOI":"10.1016\/j.biopha.2019.1097291.27cm","volume":"123","author":"N Wang","year":"2020","unstructured":"Wang N, Zhang X, Ma Z et al (2020) Combination of tanshinone IIA and astragaloside IV attenuate atherosclerotic plaque vulnerability in ApoE(-\/-) mice by activating PI3K\/AKT signaling and suppressing TRL4\/NF-\u03baB signaling. Biomed Pharmacother 123:109729. https:\/\/doi.org\/10.1016\/j.biopha.2019.1097291.27cm","journal-title":"Biomed Pharmacother"},{"key":"4667_CR51","doi-asserted-by":"publisher","first-page":"107306","DOI":"10.1016\/j.phrs.2024.1073061.27cm","volume":"207","author":"M Wang","year":"2024","unstructured":"Wang M, Huang Z, Li X et al (2024) Apabetalone, a BET protein inhibitor, inhibits kidney damage in diabetes by preventing pyroptosis via modulating the P300\/H3K27ac\/PLK1 axis. Pharmacol Res 207:107306. https:\/\/doi.org\/10.1016\/j.phrs.2024.1073061.27cm","journal-title":"Pharmacol Res"},{"key":"4667_CR52","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1530\/eje-11-06161.27cm","volume":"166","author":"W Wei","year":"2012","unstructured":"Wei W, Zhao H, Wang A et al (2012) A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome. Eur J Endocrinol 166:99\u2013105. https:\/\/doi.org\/10.1530\/eje-11-06161.27cm","journal-title":"Eur J Endocrinol"},{"key":"4667_CR53","doi-asserted-by":"publisher","unstructured":"Wen M, Chen W, Zhou Q et al (2022) Astragaloside IV regulates autophagy-mediated proliferation and apoptosis in a rat model of PCOS by activating the PPAR\u03b3 pathway. Iran J Basic Med Sci 25: 882\u2013889.https:\/\/doi.org\/10.22038\/ijbms.2022.64475.141791.27cm","DOI":"10.22038\/ijbms.2022.64475.141791.27cm"},{"key":"4667_CR54","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1142\/s0192415x245006051.27cm","volume":"52","author":"LP Wen","year":"2024","unstructured":"Wen LP, Gao SW, Chen HX et al (2024) Astragaloside IV ameliorates colonic adenomatous polyps development by orchestrating gut bifidobacterium and serum metabolome. Am J Chin Med 52:1527\u20131554. https:\/\/doi.org\/10.1142\/s0192415x245006051.27cm","journal-title":"Am J Chin Med"},{"key":"4667_CR55","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.freeradbiomed.2018.06.0341.27cm","volume":"124","author":"J Wu","year":"2018","unstructured":"Wu J, Jiang Z, Zhang H et al (2018) Sodium butyrate attenuates diabetes-induced aortic endothelial dysfunction via P300-mediated transcriptional activation of Nrf2. Free Radic Biol Med 124:454\u2013465. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.06.0341.27cm","journal-title":"Free Radic Biol Med"},{"key":"4667_CR56","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1186\/s12906-023-04148-91.27cm","volume":"23","author":"W Xiao","year":"2023","unstructured":"Xiao W, Xu Y, Baak JP et al (2023) Network module analysis and molecular docking-based study on the mechanism of astragali radix against non-small cell lung cancer. BMC Complement Med Ther 23:345. https:\/\/doi.org\/10.1186\/s12906-023-04148-91.27cm","journal-title":"BMC Complement Med Ther"},{"key":"4667_CR57","doi-asserted-by":"publisher","first-page":"119020","DOI":"10.1016\/j.jep.2024.1190201.27cm","volume":"338","author":"W Yang","year":"2025","unstructured":"Yang W, Qiu J, Zi J et al (2025) Effect of Rhei Radix Et Rhizome on treatment of polycystic ovary syndrome by regulating PI3K\/AKT pathway and targeting EGFR\/ALB in rats. J Ethnopharmacol 338:119020. https:\/\/doi.org\/10.1016\/j.jep.2024.1190201.27cm","journal-title":"J Ethnopharmacol"},{"key":"4667_CR58","doi-asserted-by":"publisher","first-page":"111468","DOI":"10.1016\/j.biopha.2021.1114681.27cm","volume":"138","author":"SW Zhang","year":"2021","unstructured":"Zhang SW, Zhou J, Gober HJ et al (2021) Effect and mechanism of berberine against polycystic ovary syndrome. Biomed Pharmacother 138:111468. https:\/\/doi.org\/10.1016\/j.biopha.2021.1114681.27cm","journal-title":"Biomed Pharmacother"},{"key":"4667_CR59","doi-asserted-by":"publisher","first-page":"155066","DOI":"10.1016\/j.phymed.2023.1550661.27cm","volume":"120","author":"M Zhang","year":"2023","unstructured":"Zhang M, Wang W, Liu K et al (2023) Astragaloside IV protects against lung injury and pulmonary fibrosis in COPD by targeting GTP-GDP domain of RAS and downregulating the RAS\/RAF\/FoxO signaling pathway. Phytomedicine 120:155066. https:\/\/doi.org\/10.1016\/j.phymed.2023.1550661.27cm","journal-title":"Phytomedicine"},{"key":"4667_CR60","doi-asserted-by":"publisher","first-page":"109239","DOI":"10.1016\/j.compbiomed.2024.1092391.27cm","volume":"183","author":"W Zhang","year":"2024","unstructured":"Zhang W, Wu Y, Yuan Y et al (2024) Identification of key biomarkers for predicting atherosclerosis progression in polycystic ovary syndrome via bioinformatics analysis and machine learning. Comput Biol Med 183:109239. https:\/\/doi.org\/10.1016\/j.compbiomed.2024.1092391.27cm","journal-title":"Comput Biol Med"},{"key":"4667_CR61","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1080\/13880209.2025.24889941.27cm","volume":"63","author":"S Zhang","year":"2025","unstructured":"Zhang S, Li S, Li X et al (2025) Anti-fibrosis effect of astragaloside IV in animal models of cardiovascular diseases and its mechanisms: a systematic review. Pharm Biol 63:250\u2013263. https:\/\/doi.org\/10.1080\/13880209.2025.24889941.27cm","journal-title":"Pharm Biol"},{"key":"4667_CR62","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1038\/aps.2016.1751.27cm","volume":"38","author":"B Zhou","year":"2017","unstructured":"Zhou B, Zhou DL, Wei XH et al (2017) Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes via AMPK activation. Acta Pharmacol Sin 38:998\u20131008. https:\/\/doi.org\/10.1038\/aps.2016.1751.27cm","journal-title":"Acta Pharmacol Sin"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04667-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04667-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04667-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T07:58:27Z","timestamp":1772006307000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04667-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,9]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["4667"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04667-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7369374\/v1","asserted-by":"object"}]},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,9]]},"assertion":[{"value":"14 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Medical Ethics Committee of the Shanxi Provincial People's Hospital. The ethics approval number is 852 from the Provincial Medical Department.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all the participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate and consent to publish"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}