{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:04:19Z","timestamp":1772791459080,"version":"3.50.1"},"reference-count":74,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s00210-025-04682-y","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T14:21:26Z","timestamp":1760019686000},"page":"3799-3817","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanistic insights into piperlongumine\u2019s neuroprotective role against cisplatin-induced neuropathy: a network pharmacology, molecular dynamics, and experimental approach"],"prefix":"10.1007","volume":"399","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7816-3721","authenticated-orcid":false,"given":"Riya","family":"Jana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4796-6016","authenticated-orcid":false,"given":"Sourav","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5323-6039","authenticated-orcid":false,"given":"Monosiz","family":"Rahaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8442-801X","authenticated-orcid":false,"given":"Biswajit","family":"Basu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8242-4541","authenticated-orcid":false,"given":"Bhupendra","family":"Prajapati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"4682_CR1","doi-asserted-by":"publisher","first-page":"891593","DOI":"10.3389\/fnagi.2022.891593","volume":"14","author":"M Alotaibi","year":"2022","unstructured":"Alotaibi M, Al-Aqil F, Alqahtani F, Alanazi M, Nadeem A, Ahmad SF et al (2022) Alleviation of cisplatin-induced neuropathic pain, neuronal apoptosis, and systemic inflammation in mice by rapamycin. Front Aging Neurosci 14:891593","journal-title":"Front Aging Neurosci"},{"key":"4682_CR2","doi-asserted-by":"publisher","first-page":"108987","DOI":"10.1016\/j.compbiomed.2024.108987","volume":"180","author":"N Andlib","year":"2024","unstructured":"Andlib N, Prabha S, Thakur SC (2024) Unraveling the molecular pathogenesis of Type 2 diabetes and its impact on female infertility: a bioinformatics and systems biology approach. Comput Biol Med 180:108987","journal-title":"Comput Biol Med"},{"issue":"1","key":"4682_CR3","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.critrevonc.2011.04.012","volume":"82","author":"AA Argyriou","year":"2012","unstructured":"Argyriou AA, Bruna J, Marmiroli P, Cavaletti G (2012) Chemotherapy-induced peripheral neurotoxicity (CIPN): an update. Crit Rev Oncol Hematol 82(1):51\u201377","journal-title":"Crit Rev Oncol Hematol"},{"issue":"13","key":"4682_CR4","doi-asserted-by":"publisher","first-page":"3248","DOI":"10.3390\/cancers14133248","volume":"14","author":"A Asensi-Cant\u00f3","year":"2022","unstructured":"Asensi-Cant\u00f3 A, L\u00f3pez-Abell\u00e1n MD, Castillo-Guardiola V, Hurtado AM, Mart\u00ednez-Penella M, Luengo-Gil G et al (2022) Antitumoral effects of tricyclic antidepressants: beyond neuropathic pain treatment. Cancers 14(13):3248","journal-title":"Cancers"},{"key":"4682_CR5","doi-asserted-by":"publisher","first-page":"566490","DOI":"10.3389\/fphar.2020.566490","volume":"11","author":"A Balkrishna","year":"2020","unstructured":"Balkrishna A, Sakat SS, Karumuri S, Singh H, Tomer M, Kumar A et al (2020) Herbal decoction Divya-Peedantak-Kwath alleviates allodynia and hyperalgesia in mice model of chemotherapy-induced peripheral neuropathy via modulation in cytokine response. Front Pharmacol 11:566490","journal-title":"Front Pharmacol"},{"issue":"3","key":"4682_CR6","doi-asserted-by":"publisher","first-page":"852","DOI":"10.3390\/pharmaceutics15030852","volume":"15","author":"G Becker","year":"2023","unstructured":"Becker G, Fialho MFP, Brusco I, Oliveira SM (2023) Kinin B1 and B2 receptors contribute to Cisplatin-induced painful peripheral neuropathy in male mice. Pharmaceutics 15(3):852","journal-title":"Pharmaceutics"},{"issue":"6","key":"4682_CR7","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1080\/00107510701244055","volume":"47","author":"JD Bekenstein","year":"2006","unstructured":"Bekenstein JD (2006) The modified Newtonian dynamics\u2014MOND and its implications for new physics. Contemp Phys 47(6):387\u2013403","journal-title":"Contemp Phys"},{"issue":"7","key":"4682_CR8","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1212\/WNL.0000000000011424","volume":"96","author":"EE Benarroch","year":"2021","unstructured":"Benarroch EE (2021) What is the mechanism of therapeutic and adverse effects of gabapentinoids? Neurology 96(7):318\u2013321","journal-title":"Neurology"},{"issue":"3","key":"4682_CR9","first-page":"176","volume":"5","author":"H Bostan","year":"2018","unstructured":"Bostan H, \u00c7abalar M, Altinay S, Kalkan Y, Tumkaya L, Kanat A et al (2018) Sciatic nerve injury following analgesic drug injection in rats: a histopathological examination. North Clin Istanb 5(3):176\u2013185","journal-title":"North Clin Istanb"},{"issue":"12","key":"4682_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20122904","volume":"20","author":"L Brandolini","year":"2019","unstructured":"Brandolini L, d\u2019Angelo M, Antonosante A, Cimini A, Allegretti M (2019) Chemokine signaling in chemotherapy-induced neuropathic pain. Int J Mol Sci 20(12):2904","journal-title":"Int J Mol Sci"},{"issue":"22","key":"4682_CR11","doi-asserted-by":"publisher","first-page":"3446","DOI":"10.1002\/cncr.28864","volume":"120","author":"M Burotto","year":"2014","unstructured":"Burotto M, Chiou VL, Lee JM, Kohn EC (2014) The MAPK pathway across different malignancies: a new perspective. Cancer 120(22):3446\u20133456","journal-title":"Cancer"},{"issue":"1","key":"4682_CR12","doi-asserted-by":"publisher","first-page":"7617261","DOI":"10.1155\/2020\/7617261","volume":"2020","author":"J Chang","year":"2020","unstructured":"Chang J, Liu L, Wang Y, Sui Y, Li H, Feng L (2020) Investigating the multitarget mechanism of traditional Chinese medicine prescription for cancer-related pain by using network pharmacology and molecular docking approach. Evid Based Complement Alternat Med 2020(1):7617261","journal-title":"Evid Based Complement Alternat Med"},{"issue":"8","key":"4682_CR13","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/s41419-019-1824-6","volume":"10","author":"W Chen","year":"2019","unstructured":"Chen W, Lian W, Yuan Y, Li M (2019) The synergistic effects of oxaliplatin and piperlongumine on colorectal cancer are mediated by oxidative stress. Cell Death Dis 10(8):600","journal-title":"Cell Death Dis"},{"issue":"17","key":"4682_CR14","doi-asserted-by":"publisher","first-page":"21546","DOI":"10.1021\/acsami.4c00793","volume":"16","author":"Y Chen","year":"2024","unstructured":"Chen Y, Deng Y, Li Y, Qin Y, Zhou Z, Yang H et al (2024) Oxygen-independent radiodynamic therapy: radiation-boosted chemodynamics for reprogramming the tumor immune environment and enhancing antitumor immune response. ACS Appl Mater Interfaces 16(17):21546\u201321556. https:\/\/doi.org\/10.1021\/acsami.4c00793","journal-title":"ACS Appl Mater Interfaces"},{"key":"4682_CR15","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1803.03010","author":"W Choi","year":"2018","unstructured":"Choi W, Yoon M-H, Park J-H (2018) Functional characterization of the C-terminus of YhaV in the Escherichia coli PrlF-YhaV toxin-antitoxin system. J Microbiol Biotechnol. https:\/\/doi.org\/10.4014\/jmb.1803.03010","journal-title":"J Microbiol Biotechnol"},{"key":"4682_CR16","doi-asserted-by":"publisher","unstructured":"Chowdhury SR, Ghosh S, Chatterjee S, Murtuja S, Rakshit G, Basu B, Prajapati B, Ali N (2025) Antidepressant-like effects of hydroxychavicol-enriched piper betle L. Leaf extract in chronic mild stress-induced rodent models and possible mechanism(s) of action involved. Chem Biodivers 22(8):e202402842. https:\/\/doi.org\/10.1002\/cbdv.202402842","DOI":"10.1002\/cbdv.202402842"},{"key":"4682_CR17","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.intimp.2016.05.007","volume":"36","author":"A Cianciulli","year":"2016","unstructured":"Cianciulli A, Calvello R, Porro C, Trotta T, Salvatore R, Panaro MA (2016) PI3k\/Akt signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-activated microglia. Int Immunopharmacol 36:282\u2013290","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"4682_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/biom10010137","volume":"10","author":"A Cianciulli","year":"2020","unstructured":"Cianciulli A, Porro C, Calvello R, Trotta T, Lofrumento DD, Panaro MA (2020) Microglia mediated neuroinflammation: focus on PI3K modulation. Biomolecules 10(1):137","journal-title":"Biomolecules"},{"issue":"8","key":"4682_CR19","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1007\/s12033-023-00831-x","volume":"66","author":"AM da Fonseca","year":"2024","unstructured":"da Fonseca AM, Caluaco BJ, Madureira JMC, Cabongo SQ, Gaieta EM, Djata F et al (2024) Screening of potential inhibitors targeting the main protease structure of SARS-CoV-2 via molecular docking, and approach with molecular dynamics, RMSD, RMSF, H-bond, SASA and MMGBSA. Mol Biotechnol 66(8):1919\u20131933","journal-title":"Mol Biotechnol"},{"issue":"6","key":"4682_CR20","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1111\/j.1747-0285.2009.00903.x","volume":"74","author":"A Del Rio","year":"2009","unstructured":"Del Rio A, Baldi BF, Rastelli G (2009) Activity prediction and structural insights of extracellular signal-regulated kinase 2 inhibitors with molecular dynamics simulations. Chem Biol Drug des 74(6):630\u2013635","journal-title":"Chem Biol Drug des"},{"issue":"2","key":"4682_CR21","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1124\/jpet.116.236182","volume":"359","author":"G Donvito","year":"2016","unstructured":"Donvito G, Wilkerson JL, Damaj MI, Lichtman AH (2016) Palmitoylethanolamide reverses paclitaxel-induced allodynia in mice. J Pharmacol Exp Ther 359(2):310\u2013318","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"4682_CR22","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1097\/j.pain.0000000000001798","volume":"161","author":"LF Ferrari","year":"2020","unstructured":"Ferrari LF, Araldi D, Green PG, Levine JD (2020) Marked sexual dimorphism in neuroendocrine mechanisms for the exacerbation of paclitaxel-induced painful peripheral neuropathy by stress. Pain 161(4):865\u2013874","journal-title":"Pain"},{"issue":"3","key":"4682_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25030762","volume":"25","author":"CR Ferraz","year":"2020","unstructured":"Ferraz CR, Carvalho TT, Manchope MF, Artero NA, Rasquel-Oliveira FS, Fattori V et al (2020) Therapeutic potential of flavonoids in pain and inflammation: mechanisms of action, pre-clinical and clinical data, and pharmaceutical development. Molecules 25(3):762","journal-title":"Molecules"},{"issue":"4","key":"4682_CR24","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1093\/bja\/aex229","volume":"119","author":"SJ Flatters","year":"2017","unstructured":"Flatters SJ, Dougherty PM, Colvin LA (2017) Clinical and preclinical perspectives on chemotherapy-induced peripheral neuropathy (CIPN): a narrative review. Br J Anaesth 119(4):737\u2013749","journal-title":"Br J Anaesth"},{"issue":"4","key":"4682_CR25","first-page":"347","volume":"21","author":"F Forouzanfar","year":"2018","unstructured":"Forouzanfar F, Hosseinzadeh H (2018) Medicinal herbs in the treatment of neuropathic pain: a review. Iran J Basic Med Sci 21(4):347","journal-title":"Iran J Basic Med Sci"},{"issue":"4","key":"4682_CR26","doi-asserted-by":"publisher","first-page":"103517","DOI":"10.1016\/j.drudis.2023.103517","volume":"28","author":"AS Gautam","year":"2023","unstructured":"Gautam AS, Singh RK (2023) Therapeutic potential of targeting IL-17 and its receptor signaling in neuroinflammation. Drug Discov Today 28(4):103517","journal-title":"Drug Discov Today"},{"issue":"W1","key":"4682_CR27","doi-asserted-by":"publisher","first-page":"W32","DOI":"10.1093\/nar\/gku293","volume":"42","author":"D Gfeller","year":"2014","unstructured":"Gfeller D, Grosdidier A, Wirth M, Daina A, Michielin O, Zoete V (2014) Swisstargetprediction: a web server for target prediction of bioactive small molecules. Nucleic Acids Res 42(W1):W32\u2013W38","journal-title":"Nucleic Acids Res"},{"key":"4682_CR28","doi-asserted-by":"publisher","first-page":"156","DOI":"10.3389\/fphar.2013.00156","volume":"4","author":"Y Han","year":"2013","unstructured":"Han Y, Smith MT (2013) Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN). Front Pharmacol 4:156","journal-title":"Front Pharmacol"},{"key":"4682_CR29","doi-asserted-by":"publisher","first-page":"175605","DOI":"10.1016\/j.ejphar.2023.175605","volume":"945","author":"B Haridevamuthu","year":"2023","unstructured":"Haridevamuthu B, Seenivasan B, Priya PS, Muthuraman S, Kumar RS, Manikandan K et al (2023) Hepatoprotective effect of dihydroxy piperlongumine in high cholesterol-induced non-alcoholic fatty liver disease zebrafish via antioxidant activity. Eur J Pharmacol 945:175605","journal-title":"Eur J Pharmacol"},{"issue":"9","key":"4682_CR30","doi-asserted-by":"publisher","first-page":"3628","DOI":"10.1073\/pnas.0708930105","volume":"105","author":"J Hendrich","year":"2008","unstructured":"Hendrich J, Van Minh AT, Heblich F, Nieto-Rostro M, Watschinger K, Striessnig J et al (2008) Pharmacological disruption of calcium channel trafficking by the \u03b12\u03b4 ligand gabapentin. Proc Natl Acad Sci USA 105(9):3628\u20133633","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"4682_CR31","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.neuron.2018.08.011","volume":"99","author":"SA Hollingsworth","year":"2018","unstructured":"Hollingsworth SA, Dror RO (2018) Molecular dynamics simulation for all. Neuron 99(6):1129\u20131143","journal-title":"Neuron"},{"issue":"1","key":"4682_CR32","doi-asserted-by":"publisher","first-page":"17549","DOI":"10.1038\/s41598-019-54152-8","volume":"9","author":"CR Hooijmans","year":"2019","unstructured":"Hooijmans CR, Draper D, Erg\u00fcn M, Scheffer GJ (2019) The effect of analgesics on stimulus evoked pain-like behaviour in animal models for chemotherapy induced peripheral neuropathy-a meta-analysis. Sci Rep 9(1):17549","journal-title":"Sci Rep"},{"issue":"2","key":"4682_CR33","doi-asserted-by":"publisher","first-page":"184","DOI":"10.2174\/1570159X15666170915143217","volume":"17","author":"L-Y Hu","year":"2019","unstructured":"Hu L-Y, Mi W-L, Wu G-C, Wang Y-Q, Mao-Ying Q-L (2019) Prevention and treatment for chemotherapy-induced peripheral neuropathy: therapies based on CIPN mechanisms. Curr Neuropharmacol 17(2):184\u2013196","journal-title":"Curr Neuropharmacol"},{"issue":"1","key":"4682_CR34","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41392-023-01620-3","volume":"8","author":"L Huangfu","year":"2023","unstructured":"Huangfu L, Li R, Huang Y, Wang S (2023) The IL-17 family in diseases: from bench to bedside. Signal Transduct Target Ther 8(1):402","journal-title":"Signal Transduct Target Ther"},{"issue":"12","key":"4682_CR35","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1080\/10286020.2024.2371040","volume":"26","author":"Z Hui","year":"2024","unstructured":"Hui Z, Lai-Fa W, Xue-Qin W, Ling D, Bin-Sheng H, Li JM (2024) Mechanisms and therapeutic potential of chinonin in nervous system diseases. J Asian Nat Prod Res 26(12):1405\u20131420. https:\/\/doi.org\/10.1080\/10286020.2024.2371040","journal-title":"J Asian Nat Prod Res"},{"key":"4682_CR36","doi-asserted-by":"publisher","first-page":"112965","DOI":"10.1016\/j.ejmech.2020.112965","volume":"210","author":"L Ji","year":"2021","unstructured":"Ji L, Qu L, Wang C, Peng W, Li S, Yang H et al (2021) Identification and optimization of piperlongumine analogues as potential antioxidant and anti-inflammatory agents via activation of Nrf2. Eur J Med Chem 210:112965","journal-title":"Eur J Med Chem"},{"issue":"9","key":"4682_CR37","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/S0898-6568(04)00028-2","volume":"16","author":"H Jijon","year":"2004","unstructured":"Jijon H, Allard B, Jobin C (2004) NF-\u03baB inducing kinase activates NF-\u03baB transcriptional activity independently of I\u03baB kinase \u03b3 through a p38 MAPK-dependent RelA phosphorylation pathway. Cell Signal 16(9):1023\u20131032","journal-title":"Cell Signal"},{"key":"4682_CR38","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3389\/fphar.2017.00086","volume":"8","author":"N Kerckhove","year":"2017","unstructured":"Kerckhove N, Collin A, Cond\u00e9 S, Chaleteix C, Pezet D, Balayssac D (2017) Long-term effects, pathophysiological mechanisms, and risk factors of chemotherapy-induced peripheral neuropathies: a comprehensive literature review. Front Pharmacol 8:86","journal-title":"Front Pharmacol"},{"issue":"3","key":"4682_CR39","first-page":"483","volume":"12","author":"F Keyhanfar","year":"2013","unstructured":"Keyhanfar F, Meymandi MS, Sepehri G, Rastegaryanzadeh R, Heravi G (2013) Evaluation of antinociceptive effect of pregabalin in mice and its combination with tramadol using tail flick test. Iranian Journal of Pharmaceutical Research: IJPR 12(3):483","journal-title":"Iranian Journal of Pharmaceutical Research: IJPR"},{"issue":"4","key":"4682_CR40","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/S0197-4580(03)00126-X","volume":"25","author":"SH Kim","year":"2004","unstructured":"Kim SH, Smith CJ, Van Eldik LJ (2004) Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1\u03b2 production. Neurobiol Aging 25(4):431\u2013439","journal-title":"Neurobiol Aging"},{"issue":"D1","key":"4682_CR41","doi-asserted-by":"publisher","first-page":"D1202","DOI":"10.1093\/nar\/gkv951","volume":"44","author":"S Kim","year":"2016","unstructured":"Kim S, Thiessen PA, Bolton EE, Chen J, Fu G, Gindulyte A et al (2016) PubChem substance and compound databases. Nucleic Acids Res 44(D1):D1202\u2013D1213","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"4682_CR42","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jphs.2018.06.004","volume":"137","author":"N Kim","year":"2018","unstructured":"Kim N, Do J, Bae J-s, Jin HK, Kim J-H, Inn K-S et al (2018) Piperlongumine inhibits neuroinflammation via regulating NF-\u03baB signaling pathways in lipopolysaccharide-stimulated BV2 microglia cells. J Pharmacol Sci 137(2):195\u2013201","journal-title":"J Pharmacol Sci"},{"issue":"4","key":"4682_CR43","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.3233\/JAD-200207","volume":"75","author":"B Kramarz","year":"2020","unstructured":"Kramarz B, Huntley RP, Rodr\u00edguez-L\u00f3pez M, Roncaglia P, Saverimuttu SC, Parkinson H et al (2020) Gene ontology curation of neuroinflammation biology improves the interpretation of Alzheimer\u2019s disease gene expression data. J Alzheimers Dis 75(4):1417\u20131435","journal-title":"J Alzheimers Dis"},{"key":"4682_CR44","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jneuroim.2019.03.012","volume":"332","author":"V Kumar","year":"2019","unstructured":"Kumar V (2019) Toll-like receptors in the pathogenesis of neuroinflammation. J Neuroimmunol 332:16\u201330","journal-title":"J Neuroimmunol"},{"issue":"8","key":"4682_CR45","first-page":"4223","volume":"29","author":"C Maih\u00f6fner","year":"2021","unstructured":"Maih\u00f6fner C, Diel I, Tesch H, Quandel T, Baron R (2021) Chemotherapy-induced peripheral neuropathy (CIPN): current therapies and topical treatment option with high-concentration capsaicin. Support Care Cancer 29(8):4223\u20134238","journal-title":"Support Care Cancer"},{"key":"4682_CR46","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00947","volume":"11","author":"J Milovanovic","year":"2020","unstructured":"Milovanovic J, Arsenijevic A, Stojanovic B, Kanjevac T, Arsenijevic D, Radosavljevic G et al (2020) Interleukin-17 in chronic inflammatory neurological diseases. Front Immunol 11:947","journal-title":"Front Immunol"},{"issue":"7","key":"4682_CR47","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1016\/j.ctrv.2014.04.004","volume":"40","author":"N Miltenburg","year":"2014","unstructured":"Miltenburg N, Boogerd W (2014) Chemotherapy-induced neuropathy: a comprehensive survey. Cancer Treat Rev 40(7):872\u2013882","journal-title":"Cancer Treat Rev"},{"key":"4682_CR48","doi-asserted-by":"publisher","DOI":"10.1021\/ed100697w","author":"HE Pence","year":"2010","unstructured":"Pence HE, Williams A, ACS Publications (2010) Chemspider: an online chemical information resource. J Chem Educ. https:\/\/doi.org\/10.1021\/ed100697w","journal-title":"J Chem Educ"},{"issue":"13","key":"4682_CR49","doi-asserted-by":"publisher","first-page":"5242","DOI":"10.1021\/acs.jmedchem.5b00410","volume":"58","author":"S Peng","year":"2015","unstructured":"Peng S, Zhang B, Meng X, Yao J, Fang J (2015) Synthesis of piperlongumine analogues and discovery of nuclear factor erythroid 2-related factor 2 (Nrf2) activators as potential neuroprotective agents. J Med Chem 58(13):5242\u20135255","journal-title":"J Med Chem"},{"key":"4682_CR50","doi-asserted-by":"publisher","unstructured":"Qian K, Yao C, Wang Y, Yang Q, Xiang S, Pei Q et al (2025) Potential of Ultrashort Pulsed Electric Fields to Disrupt Dense Structure in Glioma Tumors. IEEE transactions on bio-medical engineering. https:\/\/doi.org\/10.1109\/tbme.2025.3565520","DOI":"10.1109\/tbme.2025.3565520"},{"issue":"6","key":"4682_CR51","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1111\/bcpt.12178","volume":"114","author":"JS Quintans","year":"2014","unstructured":"Quintans JS, Antoniolli AR, Almeida JR, Santana-Filho VJ, Quintans-J\u00fanior LJ (2014) Natural products evaluated in neuropathic pain models-a systematic review. Basic Clin Pharmacol Toxicol 114(6):442\u2013450","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"9","key":"4682_CR52","doi-asserted-by":"publisher","first-page":"14951","DOI":"10.1002\/jcp.28334","volume":"234","author":"S Rezatabar","year":"2019","unstructured":"Rezatabar S, Karimian A, Rameshknia V, Parsian H, Majidinia M, Kopi TA et al (2019) RAS\/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression. J Cell Physiol 234(9):14951\u201314965","journal-title":"J Cell Physiol"},{"key":"4682_CR53","doi-asserted-by":"publisher","first-page":"101896","DOI":"10.1016\/j.pupt.2020.101896","volume":"61","author":"M Sant\u2019Ana","year":"2020","unstructured":"Sant\u2019Ana M, Souza HR, Possebon L, Corn\u00e9lio ML, Riffo-Vasquez Y, Girol AP et al (2020) Effect of piperlongumine during exposure to cigarette smoke reduces inflammation and lung injury. Pulm Pharmacol Ther 61:101896","journal-title":"Pulm Pharmacol Ther"},{"key":"4682_CR54","doi-asserted-by":"publisher","first-page":"1001276","DOI":"10.3389\/fphar.2022.1001276","volume":"13","author":"WBDR Santos","year":"2022","unstructured":"Santos WBDR, Guimaraes JO, Pina LTS, Serafini MR, Guimaraes AG (2022) Antinociceptive effect of plant-based natural products in chemotherapy-induced peripheral neuropathies: a systematic review. Front Pharmacol 13:1001276","journal-title":"Front Pharmacol"},{"issue":"5","key":"4682_CR55","doi-asserted-by":"publisher","first-page":"858","DOI":"10.3109\/08923973.2012.665461","volume":"34","author":"C Saponaro","year":"2012","unstructured":"Saponaro C, Cianciulli A, Calvello R, Dragone T, Iacobazzi F, Panaro MA (2012) The PI3K\/Akt pathway is required for LPS activation of microglial cells. Immunopharmacol Immunotoxicol 34(5):858\u2013865","journal-title":"Immunopharmacol Immunotoxicol"},{"issue":"14","key":"4682_CR56","doi-asserted-by":"publisher","first-page":"5327","DOI":"10.1080\/07391102.2020.1784795","volume":"39","author":"PS Sen Gupta","year":"2021","unstructured":"Sen Gupta PS, Biswal S, Singha D, Rana MK (2021) Binding insight of clinically oriented drug famotidine with the identified potential target of SARS-CoV-2. J Biomol Struct Dyn 39(14):5327\u20135333","journal-title":"J Biomol Struct Dyn"},{"issue":"7","key":"4682_CR57","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1080\/00207454.2016.1212854","volume":"127","author":"T Shabab","year":"2017","unstructured":"Shabab T, Khanabdali R, Moghadamtousi SZ, Kadir HA, Mohan G (2017) Neuroinflammation pathways: a general review. Int J Neurosci 127(7):624\u2013633","journal-title":"Int J Neurosci"},{"issue":"11","key":"4682_CR58","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D et al (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13(11):2498\u20132504","journal-title":"Genome Res"},{"issue":"2","key":"4682_CR59","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1093\/toxsci\/kfq066","volume":"115","author":"X Shi","year":"2010","unstructured":"Shi X, Zhou B (2010) The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos. Toxicol Sci 115(2):391\u2013400","journal-title":"Toxicol Sci"},{"key":"4682_CR60","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S278335","author":"T Shibabaw","year":"2020","unstructured":"Shibabaw T (2020) Inflammatory cytokine: IL-17A signaling pathway in patients present with COVID-19 and current treatment strategy. J Inflamm Res. https:\/\/doi.org\/10.2147\/JIR.S278335","journal-title":"J Inflamm Res"},{"key":"4682_CR61","doi-asserted-by":"publisher","unstructured":"Singh S, Baker QB, Singh DB (2022) Molecular docking and molecular dynamics simulation. In: Bioinformatics, methods and applications, pp 291\u2013304. https:\/\/doi.org\/10.1016\/B978-0-323-89775-4.00014-6","DOI":"10.1016\/B978-0-323-89775-4.00014-6"},{"issue":"1\u20132","key":"4682_CR62","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.jpain.2019.06.008","volume":"21","author":"H Starobova","year":"2020","unstructured":"Starobova H, Mueller A, Deuis JR, Carter DA, Vetter I (2020) Inflammatory and neuropathic gene expression signatures of chemotherapy-induced neuropathy induced by vincristine, cisplatin, and oxaliplatin in C57BL\/6J mice. J Pain 21(1\u20132):182\u2013194","journal-title":"J Pain"},{"issue":"5","key":"4682_CR63","doi-asserted-by":"publisher","first-page":"e0267961","DOI":"10.1371\/journal.pone.0267961","volume":"17","author":"MS Taghizadeh","year":"2022","unstructured":"Taghizadeh MS, Niazi A, Moghadam A, Afsharifar A (2022) Experimental, molecular docking and molecular dynamic studies of natural products targeting overexpressed receptors in breast cancer. PLoS ONE 17(5):e0267961","journal-title":"PLoS ONE"},{"key":"4682_CR64","doi-asserted-by":"publisher","first-page":"105994","DOI":"10.1016\/j.compbiomed.2022.105994","volume":"149","author":"H Vaghasia","year":"2022","unstructured":"Vaghasia H, Sakaria S, Prajapati J, Saraf M, Rawal RM (2022) Interactive bioinformatics analysis for the screening of hub genes and molecular docking of phytochemicals present in kitchen spices to inhibit CDK1 in cervical cancer. Comput Biol Med 149:105994","journal-title":"Comput Biol Med"},{"key":"4682_CR65","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s00401-015-1402-7","volume":"129","author":"A Waisman","year":"2015","unstructured":"Waisman A, Hauptmann J, Regen T (2015) The role of IL-17 in CNS diseases. Acta Neuropathol 129:625\u2013637","journal-title":"Acta Neuropathol"},{"key":"4682_CR66","doi-asserted-by":"publisher","first-page":"5837","DOI":"10.2147\/ijn.S466042","volume":"19","author":"Y Wang","year":"2024","unstructured":"Wang Y, Xu Y, Song J, Liu X, Liu S, Yang N et al (2024) Tumor cell-targeting and tumor microenvironment-responsive nanoplatforms for the multimodal imaging-guided photodynamic\/photothermal\/chemodynamic treatment of cervical cancer. Int J Nanomed 19:5837\u20135858. https:\/\/doi.org\/10.2147\/ijn.S466042","journal-title":"Int J Nanomed"},{"issue":"1","key":"4682_CR67","first-page":"6010952","volume":"2022","author":"P Xi","year":"2022","unstructured":"Xi P, Mao R, Wu S, Liu L, Cai C, Lu L et al (2022) Using network pharmacology and animal experiment to investigate the therapeutic mechanisms of polydatin against vincristine-induced neuropathic pain. Mediators Inflamm 2022(1):6010952","journal-title":"Mediators Inflamm"},{"issue":"4","key":"4682_CR68","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.jtcme.2015.11.001","volume":"6","author":"V Yadav","year":"2016","unstructured":"Yadav V, Chatterjee SS, Majeed M, Kumar V (2016) Preventive potentials of piperlongumine and a Piper longum extract against stress responses and pain. J Tradit Complement Med 6(4):413\u2013423","journal-title":"J Tradit Complement Med"},{"key":"4682_CR69","doi-asserted-by":"publisher","first-page":"658341","DOI":"10.3389\/fimmu.2021.658341","volume":"12","author":"M Yao","year":"2021","unstructured":"Yao M, Zhang C, Gao C, Wang Q, Dai M, Yue R et al (2021) Exploration of the shared gene signatures and molecular mechanisms between systemic lupus erythematosus and pulmonary arterial hypertension: evidence from transcriptome data. Front Immunol 12:658341","journal-title":"Front Immunol"},{"issue":"8","key":"4682_CR70","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1097\/FBP.0000000000000498","volume":"30","author":"L Zhang","year":"2019","unstructured":"Zhang L, Liu C, Yuan M, Huang C, Chen L, Su T et al (2019) Piperlongumine produces antidepressant-like effects in rats exposed to chronic unpredictable stress. Behav Pharmacol 30(8):721\u2013728","journal-title":"Behav Pharmacol"},{"key":"4682_CR71","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1581320","author":"H Zhang","year":"2025","unstructured":"Zhang H, Zhu C, Zhou X, Wang L, Deng L, He B et al (2025) Edaravone dexborneol protected neurological function by targeting NRF2\/ARE and NF-\u03baB\/AIM2 pathways in cerebral ischemia\/reperfusion injury. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2025.1581320","journal-title":"Front Pharmacol"},{"issue":"2","key":"4682_CR72","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1134\/S1068162023020243","volume":"49","author":"M Zhao","year":"2023","unstructured":"Zhao M, Wang X, Kumar S, Yao Y, Sun M (2023) A pharmacological insight of Piperlongumine, bioactive validating its therapeutic efficacy as a drug to treat inflammatory diseases. Russ J Bioorg Chem 49(2):236\u2013248","journal-title":"Russ J Bioorg Chem"},{"issue":"1","key":"4682_CR73","doi-asserted-by":"publisher","first-page":"26357","DOI":"10.1038\/srep26357","volume":"6","author":"J Zheng","year":"2016","unstructured":"Zheng J, Son DJ, Gu SM, Woo JR, Ham YW, Lee HP et al (2016) Piperlongumine inhibits lung tumor growth via inhibition of nuclear factor kappa B signaling pathway. Sci Rep 6(1):26357","journal-title":"Sci Rep"},{"issue":"1","key":"4682_CR74","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O et al (2019) Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun 10(1):1523","journal-title":"Nat Commun"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04682-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04682-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04682-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:03:06Z","timestamp":1772780586000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04682-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,9]]},"references-count":74,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["4682"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04682-y","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,9]]},"assertion":[{"value":"11 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The use of animals in this study was authorized by the Institutional Animal Ethics Committee (IAEC) under proposal number AU\/SOHMS\/DOPT\/2025\/CCSEA\/P-18.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}