{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:04:07Z","timestamp":1772791447307,"version":"3.50.1"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Vice-Chancellor of Research, Mashhad University of Medical Sciences","award":["951166"],"award-info":[{"award-number":["951166"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s00210-025-04686-8","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:32:25Z","timestamp":1760149945000},"page":"3893-3904","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Protective effect of thymoquinone against acrylamide-induced hepatotoxicity in the rat: role of MAPK and apoptosis pathways"],"prefix":"10.1007","volume":"399","author":[{"given":"Shirin","family":"Ghasemian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soghra","family":"Mehri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamshid","family":"Tabeshpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Reza","family":"Zirak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Nezhadhosein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Hosseinzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,11]]},"reference":[{"key":"4686_CR1","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jobaz.2013.04.002","volume":"66","author":"WM Abdel-Wahab","year":"2013","unstructured":"Abdel-Wahab WM (2013) Protective effect of thymoquinone on sodium fluoride-induced hepatotoxicity and oxidative stress in rats. J Basic Appl Zool 66:263\u2013270","journal-title":"J Basic Appl Zool"},{"key":"4686_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/ph14090940","volume":"14","author":"M Aboubakr","year":"2021","unstructured":"Aboubakr M, Elshafae SM, Abdelhiee EY, Fadl SE, Soliman A, Abdelkader A, Abdel-Daim MM, Bayoumi KA, Baty RS, Elgendy E, Elalfy A, Baioumy B, Ibrahim SF, Abdeen A (2021) Antioxidant and anti-inflammatory potential of thymoquinone and lycopene mitigate the chlorpyrifos-induced toxic neuropathy. Pharmaceuticals (Basel) 14:940","journal-title":"Pharmaceuticals (Basel)"},{"key":"4686_CR3","doi-asserted-by":"crossref","unstructured":"Aboubakr M, Elmahdy A, Taima S, Emam M, Farag A, Alkafafy M, Said A, Solimanp A (2023) Protective effects of N acetylcysteine and vitamin E against acrylamide-induced neurotoxicity in rats. Pak Vet J: 2074\u20137764.","DOI":"10.29261\/pakvetj\/2023.027"},{"key":"4686_CR4","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.apjtm.2016.01.039","volume":"9","author":"GO Adam","year":"2016","unstructured":"Adam GO, Rahman MM, Lee S-J, Kim G-B, Kang H-S, Kim J-S, Kim S-J (2016) Hepatoprotective effects of Nigella sativa seed extract against acetaminophen-induced oxidative stress. Asian Pac J Trop Med 9:221\u2013227","journal-title":"Asian Pac J Trop Med"},{"key":"4686_CR5","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/j.pharep.2017.04.019","volume":"69","author":"N Al-Rasheed","year":"2017","unstructured":"Al-Rasheed N, Faddah LM, Hasan IH, Ali HM, Al-Rasheed N, El Oraby NF, Mohamed MH (2017) Amelioration of panadol-induced nephrotoxicity via down-regulation of Bax\/Bcl2 ratio with some antioxidants. Pharmacol Rep 69:1088\u20131093","journal-title":"Pharmacol Rep"},{"key":"4686_CR6","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1186\/s12906-016-1322-7","volume":"16","author":"S Ansar","year":"2016","unstructured":"Ansar S, Siddiqi NJ, Zargar S, Ganaie MA, Abudawood M (2016) Hepatoprotective effect of quercetin supplementation against acrylamide-induced DNA damage in wistar rats. BMC Complement Altern Med 16:327","journal-title":"BMC Complement Altern Med"},{"key":"4686_CR7","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.etap.2017.12.017","volume":"58","author":"S Ashraf","year":"2018","unstructured":"Ashraf S, Anjum AA, Ahmad A, Firyal S, Sana S, Latif AA (2018) In vitro activity of Nigella sativa against antibiotic resistant Salmonella enterica. Environ Toxicol Pharmacol 58:54\u201358","journal-title":"Environ Toxicol Pharmacol"},{"key":"4686_CR8","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.ijsu.2013.12.013","volume":"12","author":"\u0130\u00d6 Aycan","year":"2014","unstructured":"Aycan \u0130\u00d6, T\u00fcfek A, Tokg\u00f6z O, Evliyao\u011flu O, F\u0131rat U, Kavak G\u00d6, Turgut H, Y\u00fcksel MU (2014) Thymoquinone treatment against acetaminophen-induced hepatotoxicity in rats. Int J Surg 12:213\u2013218","journal-title":"Int J Surg"},{"key":"4686_CR9","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1007\/s00210-023-02739-4","volume":"397","author":"A Behairy","year":"2024","unstructured":"Behairy A, Elkomy A, Elsayed F, Gaballa MMS, Soliman A, Aboubakr M (2024a) Antioxidant and anti-inflammatory potential of spirulina and thymoquinone mitigate the methotrexate-induced neurotoxicity. Naunyn Schmiedebergs Arch Pharmacol 397:1875\u20131888","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"4686_CR10","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1007\/s43450-023-00470-y","volume":"34","author":"A Behairy","year":"2024","unstructured":"Behairy A, Elkomy A, Elsayed F, Gaballa MMS, Soliman A, Aboubakr M (2024b) Spirulina and thymoquinone protect against methotrexate-induced hepatic injury in rats. Rev Bras Farmacogn 34:154\u2013167","journal-title":"Rev Bras Farmacogn"},{"key":"4686_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111679","volume":"145","author":"N Bo","year":"2020","unstructured":"Bo N, Yilin H, Chaoyue Y, Lu L, Yuan Y (2020) Acrylamide induces NLRP3 inflammasome activation via oxidative stress- and endoplasmic reticulum stress-mediated MAPK pathway in HepG2 cells. Food Chem Toxicol 145:111679","journal-title":"Food Chem Toxicol"},{"key":"4686_CR12","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1016\/j.biopha.2017.08.018","volume":"94","author":"A Bouhlel","year":"2017","unstructured":"Bouhlel A, Ben Mosbah I, Hadj Abdallah N, Ribault C, Viel R, Manna\u00ef S, Corlu A, Ben Abdennebi H (2017) Thymoquinone prevents endoplasmic reticulum stress and mitochondria-induced apoptosis in a rat model of partial hepatic warm ischemia reperfusion. Biomed Pharmacother 94:964\u2013973","journal-title":"Biomed Pharmacother"},{"key":"4686_CR13","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.fct.2012.10.025","volume":"51","author":"JH Chen","year":"2013","unstructured":"Chen JH, Yang CH, Wang YS, Lee JG, Cheng CH, Chou CC (2013) Acrylamide-induced mitochondria collapse and apoptosis in human astrocytoma cells. Food Chem Toxicol 51:446\u2013452","journal-title":"Food Chem Toxicol"},{"key":"4686_CR14","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.foodchem.2018.10.004","volume":"276","author":"J Cheng","year":"2019","unstructured":"Cheng J, Zhang S, Wang S, Wang P, Su X-O, Xie J (2019) Rapid and sensitive detection of acrylamide in fried food using dispersive solid-phase extraction combined with surface-enhanced raman spectroscopy. Food Chem 276:157\u2013163","journal-title":"Food Chem"},{"key":"4686_CR15","volume":"7","author":"S AQ Das","year":"2012","unstructured":"AQ Das S, Dey KK, Dey G, Pal I, Majumder A, MaitiChoudhury S, kundu SC, Mandal M (2012) Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma. PLoS One 7:e46641-e46641","journal-title":"PLoS One"},{"key":"4686_CR16","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.biopha.2017.02.044","volume":"89","author":"AH El-Far","year":"2017","unstructured":"El-Far AH, Korshom MA, Mandour AA, El-Bessoumy AA, El-Sayed YS (2017) Hepatoprotective efficacy of Nigella sativa seeds dietary supplementation against lead acetate-induced oxidative damage in rabbit \u2013 purification and characterization of glutathione peroxidase. Biomed Pharmacother 89:711\u2013718","journal-title":"Biomed Pharmacother"},{"key":"4686_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.lfs.2017.05.005","volume":"180","author":"NM Elsherbiny","year":"2017","unstructured":"Elsherbiny NM, Maysarah NM, El-Sherbiny M, Al-Gayyar MM (2017) Renal protective effects of thymoquinone against sodium nitrite-induced chronic toxicity in rats: impact on inflammation and apoptosis. Life Sci 180:1\u20138","journal-title":"Life Sci"},{"key":"4686_CR18","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s12011-015-0453-x","volume":"170","author":"M Erboga","year":"2016","unstructured":"Erboga M, Kanter M, Aktas C, Sener U, Fidanol Erboga Z, Bozdemir Donmez Y, Gurel A (2016) Thymoquinone ameliorates cadmium-induced nephrotoxicity, apoptosis, and oxidative stress in rats is based on its anti-apoptotic and anti-oxidant properties. Biol Trace Elem Res 170:165\u2013172","journal-title":"Biol Trace Elem Res"},{"key":"4686_CR19","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1002\/ar.24587","volume":"304","author":"OS Erfan","year":"2021","unstructured":"Erfan OS, Sonpol HMA, Abd El-Kader M (2021) Protective effect of rapamycin against acrylamide-induced hepatotoxicity: the associations between autophagy, apoptosis, and necroptosis. Anat Rec 304:1984\u20131998","journal-title":"Anat Rec"},{"key":"4686_CR20","doi-asserted-by":"publisher","first-page":"3262","DOI":"10.1002\/ptr.6774","volume":"34","author":"A Foroutanfar","year":"2020","unstructured":"Foroutanfar A, Mehri S, Kamyar M, Tandisehpanah Z, Hosseinzadeh H (2020) Protective effect of punicalagin, the main polyphenol compound of pomegranate, against acrylamide-induced neurotoxicity and hepatotoxicity in rats. Phytother Res 34:3262\u20133272","journal-title":"Phytother Res"},{"key":"4686_CR21","first-page":"823","volume":"65","author":"SR Galaly","year":"2014","unstructured":"Galaly SR, Ahmed OM, Mahmoud AM (2014) Thymoquinone and curcumin prevent gentamicin-induced liver injury by attenuating oxidative stress, inflammation and apoptosis. J Physiol Pharmacol\u202f: an Official Journal of the Polish Physiological Society 65:823\u2013832","journal-title":"J Physiol Pharmacol : an Official Journal of the Polish Physiological Society"},{"key":"4686_CR22","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.biopha.2017.08.139","volume":"95","author":"S Gedik","year":"2017","unstructured":"Gedik S, Erdemli ME, Gul M, Yigitcan B, Gozukara Bag H, Aksungur Z, Altinoz E (2017) Hepatoprotective effects of crocin on biochemical and histopathological alterations following acrylamide-induced liver injury in Wistar rats. Biomed Pharmacother 95:764\u2013770","journal-title":"Biomed Pharmacother"},{"key":"4686_CR23","first-page":"1041","volume":"24","author":"M Ghasemzadeh Rahbardar","year":"2021","unstructured":"Ghasemzadeh Rahbardar M, Cheraghi Farmad H, Hosseinzadeh H, Mehri S (2021) Protective effects of selenium on acrylamide-induced neurotoxicity and hepatotoxicity in rats. Iran J Basic Med Sci 24:1041\u20131049","journal-title":"Iran J Basic Med Sci"},{"key":"4686_CR24","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1503\/cmaj.1040752","volume":"172","author":"EG Giannini","year":"2005","unstructured":"Giannini EG, Testa R, Savarino V (2005) Liver enzyme alteration: a guide for clinicians. CMAJ 172:367\u2013379","journal-title":"CMAJ"},{"key":"4686_CR25","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.etp.2017.05.004","volume":"69","author":"SM Hamdy","year":"2017","unstructured":"Hamdy SM, Shabaan AM, Abdel Latif AKM, Abdel-Aziz AM, Amin AM (2017) Protective effect of hesperidin and tiger nut against acrylamide toxicity in female rats. Exp Toxicol Pathol 69:580\u2013588","journal-title":"Exp Toxicol Pathol"},{"key":"4686_CR26","first-page":"927","volume":"20","author":"SM Hosseini","year":"2017","unstructured":"Hosseini SM, Taghiabadi E, Abnous K, Hariri AT, Pourbakhsh H, Hosseinzadeh H (2017) Protective effect of thymoquinone, the active constituent of Nigella sativa fixed oil, against ethanol toxicity in rats. Iran J Basic Med Sci 20:927\u2013939","journal-title":"Iran J Basic Med Sci"},{"key":"4686_CR27","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.phymed.2006.12.005","volume":"14","author":"H Hosseinzadeh","year":"2007","unstructured":"Hosseinzadeh H, Parvardeh S, Asl MN, Sadeghnia HR, Ziaee TJP (2007) Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus. Phytomedicine 14:621\u2013627","journal-title":"Phytomedicine"},{"key":"4686_CR28","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.envpol.2017.11.095","volume":"234","author":"M Huang","year":"2018","unstructured":"Huang M, Jiao J, Wang J, Xia Z, Zhang YJE (2018) Exposure to acrylamide induces cardiac developmental toxicity in zebrafish during cardiogenesis. Environ Pollut 234:656\u2013666","journal-title":"Environ Pollut"},{"key":"4686_CR29","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.etap.2013.07.010","volume":"36","author":"A Jaswal","year":"2013","unstructured":"Jaswal A, Sinha N, Bhadauria M, Shrivastava S, Shukla S (2013) Therapeutic potential of thymoquinone against anti-tuberculosis drugs induced liver damage. Environ Toxicol Pharmacol 36:779\u2013786","journal-title":"Environ Toxicol Pharmacol"},{"key":"4686_CR30","doi-asserted-by":"crossref","unstructured":"Kandemir FM, Y\u0131ld\u0131r\u0131m S, Kucukler S, Caglayan C, Darendelio\u011flu E, Dortbudak MB (2020) Protective effects of morin against acrylamide-induced hepatotoxicity and nephrotoxicity: A multi-biomarker approach. Food Chem Toxicol 138:\u00a0111190","DOI":"10.1016\/j.fct.2020.111190"},{"key":"4686_CR31","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jep.2019.01.009","volume":"234","author":"A Khonche","year":"2019","unstructured":"Khonche A, Fallah Huseini H, Gholamian M, Mohtashami R, Nabati F, Kianbakht S (2019) Standardized Nigella sativa seed oil ameliorates hepatic steatosis, aminotransferase and lipid levels in non-alcoholic fatty liver disease: a randomized, double-blind and placebo-controlled clinical trial. J Ethnopharmacol 234:106\u2013111","journal-title":"J Ethnopharmacol"},{"key":"4686_CR32","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1136\/bmj.38050.593634.63","volume":"328","author":"HC Kim","year":"2004","unstructured":"Kim HC, Nam CM, Jee SH, Han KH, Oh DK, Suh I (2004) Normal serum aminotransferase concentration and risk of mortality from liver diseases: prospective cohort study. BMJ 328:983","journal-title":"BMJ"},{"key":"4686_CR33","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1021\/tx500341z","volume":"28","author":"KH Kim","year":"2015","unstructured":"Kim KH, Park B, Rhee DK, Pyo S (2015) Acrylamide induces senescence in macrophages through a process involving ATF3, ROS, p38\/JNK, and a telomerase-independent pathway. Chem Res Toxicol 28:71\u201386","journal-title":"Chem Res Toxicol"},{"key":"4686_CR34","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1080\/10408398.2019.1588222","volume":"60","author":"A Koszucka","year":"2020","unstructured":"Koszucka A, Nowak A, Nowak I, Motyl I (2020) Acrylamide in human diet, its metabolism, toxicity, inactivation and the associated European Union legal regulations in food industry. Crit Rev Food Sci Nutr 60:1677\u20131692","journal-title":"Crit Rev Food Sci Nutr"},{"key":"4686_CR35","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.acthis.2015.09.004","volume":"117","author":"R Kovac","year":"2015","unstructured":"Kovac R, Rajkovic V, Koledin I, Matavulj M (2015) Acrylamide alters glycogen content and enzyme activities in the liver of juvenile rat. Acta Histochem 117:712\u2013717","journal-title":"Acta Histochem"},{"key":"4686_CR36","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2018.00014","volume":"5","author":"J Kumar","year":"2018","unstructured":"Kumar J, Das S, Teoh SL (2018) Dietary acrylamide and the risks of developing cancer: facts to ponder. Front Nutr 5:14","journal-title":"Front Nutr"},{"key":"4686_CR37","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.tiv.2012.07.007","volume":"27","author":"JH Lee","year":"2013","unstructured":"Lee JH, Lee SW, Choi SH, Kim SH, Kim WJ, Jung JY (2013) P38 MAP kinase and ERK play an important role in nitric oxide-induced apoptosis of the mouse embryonic stem cells. Toxicol in Vitro 27:492\u2013498","journal-title":"Toxicol in Vitro"},{"key":"4686_CR38","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.tiv.2014.01.005","volume":"28","author":"J-G Lee","year":"2014","unstructured":"Lee J-G, Wang Y-S, Chou C-C (2014) Acrylamide-induced apoptosis in rat primary astrocytes and human astrocytoma cell lines. Toxicol in Vitro 28:562\u2013570","journal-title":"Toxicol in Vitro"},{"key":"4686_CR39","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.imr.2018.01.005","volume":"7","author":"M Mahboubi","year":"2018","unstructured":"Mahboubi M (2018) Natural therapeutic approach of Nigella sativa (black seed) fixed oil in management of sinusitis. Integr Med Res 7:27\u201332","journal-title":"Integr Med Res"},{"key":"4686_CR40","first-page":"101","volume":"18","author":"S Mehri","year":"2014","unstructured":"Mehri S, Karami HV, Hassani FV, Hosseinzadeh H (2014a) Chrysin reduced acrylamide-induced neurotoxicity in both in vitro and in vivo assessments. Iran Biomed J 18:101\u2013106","journal-title":"Iran Biomed J"},{"key":"4686_CR41","first-page":"1007","volume":"17","author":"S Mehri","year":"2014","unstructured":"Mehri S, Shahi M, Razavi BM, Hassani FV, Hosseinzadeh H (2014b) Neuroprotective effect of thymoquinone in acrylamide-induced neurotoxicity in Wistar rats. Iran J Basic Med Sci 17:1007\u20131011","journal-title":"Iran J Basic Med Sci"},{"key":"4686_CR42","first-page":"902","volume":"18","author":"S Mehri","year":"2015","unstructured":"Mehri S, Abnous K, Khooei A, Mousavi SH, Shariaty VM, Hosseinzadeh H (2015) Crocin reduced acrylamide-induced neurotoxicity in Wistar rat through inhibition of oxidative stress. Iran J Basic Med Sci 18:902\u2013908","journal-title":"Iran J Basic Med Sci"},{"key":"4686_CR43","first-page":"958","volume":"17","author":"H Mollazadeh","year":"2014","unstructured":"Mollazadeh H, Hosseinzadeh H (2014) The protective effect of Nigella sativa against liver injury: a review. Iran J Basic Med Sci 17:958\u2013966","journal-title":"Iran J Basic Med Sci"},{"key":"4686_CR44","doi-asserted-by":"publisher","first-page":"158","DOI":"10.3831\/KPI.2017.20.019","volume":"20","author":"H Mollazadeh","year":"2017","unstructured":"Mollazadeh H, Afshari AR, Hosseinzadeh H (2017) Review on the potential therapeutic roles of Nigella sativa in the treatment of patients with cancer: involvement of apoptosis: - black cumin and cancer. J Pharmacopunct 20:158\u2013172","journal-title":"J Pharmacopunct"},{"key":"4686_CR45","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.apsusc.2018.05.202","volume":"455","author":"I Negut","year":"2018","unstructured":"Negut I, Grumezescu V, Ficai A, Grumezescu AM, Holban AM, Popescu RC, Savu D, Vasile BS, Socol GJASS (2018) Maple deposition of Nigella sativa functionalized Fe3O4 nanoparticles for antimicrobial coatings. Appl Surf Sci 455:513\u2013521","journal-title":"Appl Surf Sci"},{"key":"4686_CR46","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1002\/ptr.6982","volume":"35","author":"Z Oskouei","year":"2021","unstructured":"Oskouei Z, Mehri S, Kalalinia F, Hosseinzadeh H (2021) Evaluation of the effect of thymoquinone in d-galactose-induced memory impairments in rats: role of MAPK, oxidative stress, and neuroinflammation pathways and telomere length. Phytother Res 35:2252\u20132266","journal-title":"Phytother Res"},{"key":"4686_CR47","doi-asserted-by":"publisher","first-page":"4781","DOI":"10.1007\/s12035-016-0021-1","volume":"54","author":"X Pan","year":"2017","unstructured":"Pan X, Yan D, Wang D, Wu X, Zhao W, Lu Q, Yan H (2017) Mitochondrion-mediated apoptosis induced by acrylamide is regulated by a balance between Nrf2 antioxidant and MAPK signaling pathways in PC12 cells. Mol Neurobiol 54:4781\u20134794","journal-title":"Mol Neurobiol"},{"key":"4686_CR48","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8416763","volume":"2017","author":"G Pizzino","year":"2017","unstructured":"Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, Squadrito F, Altavilla D, Bitto A (2017) Oxidative stress: harms and benefits for human health. Oxid Med Cell Longev 2017:8416763","journal-title":"Oxid Med Cell Longev"},{"key":"4686_CR49","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.tifs.2019.01.003","volume":"85","author":"CS Pundir","year":"2019","unstructured":"Pundir CS, Yadav N, Chhillar AK (2019) Occurrence, synthesis, toxicity and detection methods for acrylamide determination in processed foods with special reference to biosensors: a review. Trends Food Sci Technol 85:211\u2013225","journal-title":"Trends Food Sci Technol"},{"key":"4686_CR50","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1016\/j.toxrep.2018.11.006","volume":"5","author":"E Rivadeneyra-Dom\u00ednguez","year":"2018","unstructured":"Rivadeneyra-Dom\u00ednguez E, Becerra-Contreras Y, V\u00e1zquez-Luna A, D\u00edaz-Sobac R, Rodr\u00edguez-Landa JF (2018) Alterations of blood chemistry, hepatic and renal function, and blood cytometry in acrylamide-treated rats. Toxicol Rep 5:1124\u20131128","journal-title":"Toxicol Rep"},{"key":"4686_CR51","doi-asserted-by":"crossref","unstructured":"Rizk M, Abo-El-matty D, Aly H, Abd-Alla H, Saleh S, Younis E, Elnahrawy A, Haroun AJTr (2018) Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity. Toxicol Rep 5:929\u2013942.","DOI":"10.1016\/j.toxrep.2018.08.021"},{"key":"4686_CR52","doi-asserted-by":"publisher","first-page":"303","DOI":"10.4236\/ajac.2024.159020","volume":"15","author":"M Rizzo","year":"2024","unstructured":"Rizzo M (2024) Measurement of malondialdehyde as a biomarker of lipid oxidation in fish. Am J Anal Chem 15:303\u2013332","journal-title":"Am J Anal Chem"},{"key":"4686_CR53","first-page":"11","volume":"2009","author":"N Sharma","year":"2009","unstructured":"Sharma N, Ahirwar D, Jhade D, Gupta S (2009) Medicinal and phamacological potential of nigella sativa: a review. Ethnobotanical Rev 2009:11","journal-title":"Ethnobotanical Rev"},{"key":"4686_CR54","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1007\/s11064-019-02741-4","volume":"44","author":"J Tabeshpour","year":"2019","unstructured":"Tabeshpour J, Mehri S, Abnous K, Hosseinzadeh H (2019) Neuroprotective effects of thymoquinone in acrylamide-induced peripheral nervous system toxicity through MAPKinase and apoptosis pathways in rat. Neurochem Res 44:1101\u20131112","journal-title":"Neurochem Res"},{"key":"4686_CR55","doi-asserted-by":"crossref","unstructured":"Tavakkoli A, Hosseinzadeh H (2020) Chapter 21 - Nigella sativa L. and thymoquinone as neuroprotective antioxidants. In: Martin CR, Preedy VR (eds.) Oxidative stress and dietary antioxidants in neurological diseases. Academic Press, pp. 325\u2013341.","DOI":"10.1016\/B978-0-12-817780-8.00021-9"},{"key":"4686_CR56","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/978-1-61779-867-2_20","volume":"889","author":"TE Tipple","year":"2012","unstructured":"Tipple TE, Rogers LK (2012) Methods for the determination of plasma or tissue glutathione levels. Methods Mol Biol 889:315\u2013324","journal-title":"Methods Mol Biol"},{"key":"4686_CR57","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1179\/acb.2004.042","volume":"59","author":"C Verslype","year":"2004","unstructured":"Verslype C (2004) Evaluation of abnormal liver-enzyme results in asymptomatic patients. Acta Clin Belg 59:285\u2013289","journal-title":"Acta Clin Belg"},{"key":"4686_CR58","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1080\/01635581.2014.916323","volume":"66","author":"MK Virk-Baker","year":"2014","unstructured":"Virk-Baker MK, Nagy TR, Barnes S, Groopman J (2014) Dietary acrylamide and human cancer: a systematic review of literature. Nutr Cancer 66:774\u2013790","journal-title":"Nutr Cancer"},{"key":"4686_CR59","doi-asserted-by":"publisher","first-page":"7285","DOI":"10.1039\/C4RA15065A","volume":"5","author":"Y Yang","year":"2015","unstructured":"Yang Y, Bai T, Sun P, Lian L-H, Yao Y-L, Zheng H-X, Li X, Li J-B, Wu Y-L, Nan J-X (2015) Thymoquinone, a bioactive component of Nigella sativa Linn seeds or traditional spice, attenuates acute hepatic failure and blocks apoptosis via the MAPK signaling pathway in mice. RSC Adv 5:7285\u20137290","journal-title":"RSC Adv"},{"key":"4686_CR60","doi-asserted-by":"crossref","unstructured":"Yildizbayrak N, Erkan M (2019) Therapeutic effect of curcumin on acrylamide-induced apoptosis mediated by MAPK signaling pathway in Leydig cells. J Biochem Mol Toxicol 33:e22326","DOI":"10.1002\/jbt.22326"},{"key":"4686_CR61","doi-asserted-by":"crossref","unstructured":"Zamani E, Shaki F, AbedianKenari S, Shokrzadeh M (2017) Acrylamide induces immunotoxicity through reactive oxygen species production and caspase-dependent apoptosis in mice splenocytes via the mitochondria-dependent signaling pathways. Biomed Pharmacother 94:523-530","DOI":"10.1016\/j.biopha.2017.07.033"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04686-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04686-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04686-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:03:13Z","timestamp":1772780593000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04686-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,11]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["4686"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04686-8","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,11]]},"assertion":[{"value":"6 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests\u00a0and also H.H. is the Editor of Naunyn-Schmiedebergs Arch Pharmacol and followed the submission guidelines of the journal (\n                      \n                      ).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}