{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:04:25Z","timestamp":1772791465737,"version":"3.50.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s00210-025-04702-x","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T06:45:10Z","timestamp":1761115510000},"page":"4507-4517","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Honokiol inhibits cell migration and invasion by blocking EMT via Snail\/Slug axis in endometriosis"],"prefix":"10.1007","volume":"399","author":[{"given":"Xiaojuan","family":"Kong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"issue":"2","key":"4702_CR1","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1210\/jc.2008-1180","volume":"94","author":"E Attar","year":"2009","unstructured":"Attar E (2009) Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis. J Clin Endocrinol Metab 94(2):623\u2013631","journal-title":"J Clin Endocrinol Metab"},{"key":"4702_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00715","volume":"10","author":"L Avila-Carrasco","year":"2019","unstructured":"Avila-Carrasco L (2019) Natural plants compounds as modulators of epithelial-to-mesenchymal transition. Front Pharmacol 10:715","journal-title":"Front Pharmacol"},{"issue":"4","key":"4702_CR3","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1007\/s00404-013-3040-4","volume":"289","author":"J Bartley","year":"2014","unstructured":"Bartley J (2014) Epithelial to mesenchymal transition (EMT) seems to be regulated differently in endometriosis and the endometrium. Arch Gynecol Obstet 289(4):871\u2013881","journal-title":"Arch Gynecol Obstet"},{"issue":"3","key":"4702_CR4","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.fertnstert.2012.06.029","volume":"98","author":"RO Burney","year":"2012","unstructured":"Burney RO, Giudice LC (2012) Pathogenesis and pathophysiology of endometriosis. Fertil Steril 98(3):511\u2013519","journal-title":"Fertil Steril"},{"issue":"24","key":"4702_CR5","first-page":"5527","volume":"21","author":"Y Cai","year":"2017","unstructured":"Cai Y et al (2017) Overexpression of TAFI promotes epithelial mesenchymal transition in endometriosis. Eur Rev Med Pharmacol Sci 21(24):5527\u20135533","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"6","key":"4702_CR6","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.3892\/etm.2021.10911","volume":"22","author":"W Chen","year":"2021","unstructured":"Chen W et al (2021) Honokiol inhibits endoplasmic reticulum stress-associated lipopolysaccharide-induced inflammation and apoptosis in bovine endometrial epithelial cells. Exp Ther Med 22(6):1476","journal-title":"Exp Ther Med"},{"issue":"5","key":"4702_CR7","first-page":"447","volume":"69","author":"A Czyzyk","year":"2017","unstructured":"Czyzyk A et al (2017) Update on endometriosis pathogenesis. Minerva Ginecol 69(5):447\u2013461","journal-title":"Minerva Ginecol"},{"issue":"3","key":"4702_CR8","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1097\/AOG.0000000000002469","volume":"131","author":"T Falcone","year":"2018","unstructured":"Falcone T, Flyckt R (2018) Clinical management of endometriosis. Obstet Gynecol 131(3):557\u2013571","journal-title":"Obstet Gynecol"},{"issue":"9447","key":"4702_CR9","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","volume":"364","author":"LC Giudice","year":"2004","unstructured":"Giudice LC, Kao LC (2004) Endometriosis. Lancet 364(9447):1789\u20131799","journal-title":"Lancet"},{"issue":"9","key":"4702_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2022.166431","volume":"1868","author":"R Gundamaraju","year":"2022","unstructured":"Gundamaraju R et al (2022) Autophagy and EMT in cancer and metastasis: who controls whom? Biochimica et Biophysica Acta (BBA) 1868(9):166431","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"key":"4702_CR11","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-91","volume":"12","author":"AM Haslehurst","year":"2012","unstructured":"Haslehurst AM et al (2012) EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer. BMC Cancer 12:91","journal-title":"BMC Cancer"},{"issue":"2","key":"4702_CR12","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1177\/1933719116655622","volume":"24","author":"Y He","year":"2017","unstructured":"He Y et al (2017) Effects of hydrogen gas inhalation on endometriosis in rats. Reprod Sci 24(2):324\u2013331","journal-title":"Reprod Sci"},{"key":"4702_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153214","volume":"77","author":"YW Hsu","year":"2020","unstructured":"Hsu YW et al (2020) The effects of isoliquiritigenin on endometriosis in vivo and in vitro study. Phytomedicine 77:153214","journal-title":"Phytomedicine"},{"issue":"2","key":"4702_CR14","first-page":"282","volume":"106","author":"RC Jones","year":"1984","unstructured":"Jones RC (1984) The effect of a luteinizing hormone releasing hormone (LRH) agonist (Wy-40,972), levonorgestrel, danazol and ovariectomy on experimental endometriosis in the rat. Acta Endocrinol (Copenh) 106(2):282\u2013288","journal-title":"Acta Endocrinol (Copenh)"},{"issue":"1","key":"4702_CR15","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1089\/fpd.2020.2805","volume":"18","author":"H Kim","year":"2021","unstructured":"Kim H, Lim CY, Chung MS (2021) Magnolia officinalis and its honokiol and magnolol constituents inhibit human norovirus surrogates. Foodborne Pathog Dis 18(1):24\u201330","journal-title":"Foodborne Pathog Dis"},{"key":"4702_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061915","author":"L Konrad","year":"2020","unstructured":"Konrad L (2020) Epithelial-mesenchymal transition in endometriosis-when does it happen? J Clin Med. https:\/\/doi.org\/10.3390\/jcm9061915","journal-title":"J Clin Med"},{"issue":"11","key":"4702_CR17","doi-asserted-by":"publisher","first-page":"11348","DOI":"10.21037\/apm-21-2175","volume":"10","author":"L Li","year":"2021","unstructured":"Li L (2021) All-trans retinoic acid inhibits epithelial-to-mesenchymal transition (EMT) through the down-regulation of IL-6 in endometriosis. Ann Palliat Med 10(11):11348\u201311361","journal-title":"Ann Palliat Med"},{"issue":"5","key":"4702_CR18","doi-asserted-by":"publisher","first-page":"383","DOI":"10.14348\/molcells.2014.0009","volume":"37","author":"W Li","year":"2014","unstructured":"Li W et al (2014) Honokiol suppresses renal cancer cells\u2019 metastasis via dual-blocking epithelial-mesenchymal transition and cancer stem cell properties through modulating miR-141\/ZEB2 signaling. Mol Cells 37(5):383\u2013388","journal-title":"Mol Cells"},{"key":"4702_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.937988","volume":"13","author":"T Lih Yuan","year":"2022","unstructured":"Lih Yuan T et al (2022) Oestrogen-induced epithelial-mesenchymal transition (EMT) in endometriosis: aetiology of vaginal agenesis in Mayer-Rokitansky-K\u00fcster-Hauser (MRKH) syndrome. Front Physiol 13:937988","journal-title":"Front Physiol"},{"issue":"3","key":"4702_CR20","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1093\/jpp\/rgac102","volume":"75","author":"A Liu","year":"2023","unstructured":"Liu A et al (2023a) Honokiol alleviates sepsis-associated cardiac dysfunction via attenuating inflammation, apoptosis and oxidative stress. J Pharm Pharmacol 75(3):397\u2013406","journal-title":"J Pharm Pharmacol"},{"key":"4702_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2022.101679","volume":"79","author":"HY Liu","year":"2023","unstructured":"Liu HY et al (2023b) A review of the effects of estrogen and epithelial-mesenchymal transformation on intrauterine adhesion and endometriosis. Transpl Immunol 79:101679","journal-title":"Transpl Immunol"},{"issue":"1","key":"4702_CR22","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s43032-019-00016-5","volume":"27","author":"Y Liu","year":"2020","unstructured":"Liu Y (2020) MiR-199a-5p targets ZEB1 to inhibit the epithelial-mesenchymal transition of ovarian ectopic endometrial stromal cells via PI3K\/Akt\/mTOR signal pathway in vitro and in vivo. Reprod Sci 27(1):110\u2013118","journal-title":"Reprod Sci"},{"issue":"12","key":"4702_CR23","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1038\/aps.2016.81","volume":"37","author":"XQ Lv","year":"2016","unstructured":"Lv XQ et al (2016) Honokiol inhibits EMT-mediated motility and migration of human non-small cell lung cancer cells in vitro by targeting c-FLIP. Acta Pharmacol Sin 37(12):1574\u20131586","journal-title":"Acta Pharmacol Sin"},{"issue":"3","key":"4702_CR24","first-page":"349","volume":"7","author":"C Mehedintu","year":"2014","unstructured":"Mehedintu C et al (2014) Endometriosis still a challenge. J Med Life 7(3):349\u2013357","journal-title":"J Med Life"},{"issue":"Suppl 1","key":"4702_CR25","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.fertnstert.2003.11.015","volume":"81","author":"N Mulayim","year":"2004","unstructured":"Mulayim N et al (2004) Regulation of endometrial stromal cell matrix metalloproteinase activity and invasiveness by interleukin-8. Fertil Steril 81(Suppl 1):904\u2013911","journal-title":"Fertil Steril"},{"issue":"1","key":"4702_CR26","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.bbrc.2013.04.037","volume":"435","author":"HP Naber","year":"2013","unstructured":"Naber HP et al (2013) Snail and slug, key regulators of TGF-\u03b2-induced EMT, are sufficient for the induction of single-cell invasion. Biochem Biophys Res Commun 435(1):58\u201363","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"4702_CR27","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.tcb.2018.12.001","volume":"29","author":"I Pastushenko","year":"2019","unstructured":"Pastushenko I, Blanpain C (2019) EMT transition states during tumor progression and metastasis. Trends Cell Biol 29(3):212\u2013226","journal-title":"Trends Cell Biol"},{"key":"4702_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.728583","volume":"11","author":"T Qin","year":"2021","unstructured":"Qin T et al (2021) Honokiol suppresses perineural invasion of pancreatic cancer by inhibiting SMAD2\/3 signaling. Front Oncol 11:728583","journal-title":"Front Oncol"},{"key":"4702_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153647","volume":"90","author":"A Rauf","year":"2021","unstructured":"Rauf A (2021) Honokiol: a review of its pharmacological potential and therapeutic insights. Phytomedicine 90:153647","journal-title":"Phytomedicine"},{"key":"4702_CR30","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200388","author":"M Recouvreux","year":"2020","unstructured":"Recouvreux M et al (2020) Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer. J Exp Med. https:\/\/doi.org\/10.1084\/jem.20200388","journal-title":"J Exp Med"},{"key":"4702_CR31","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.14817.1","author":"E Rolla","year":"2019","unstructured":"Rolla E (2019) Endometriosis: advances and controversies in classification, pathogenesis, diagnosis, and treatment. F1000Res. https:\/\/doi.org\/10.12688\/f1000research.14817.1","journal-title":"F1000Res"},{"issue":"16","key":"4702_CR32","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1055\/a-0642-1966","volume":"84","author":"A Sarrica","year":"2018","unstructured":"Sarrica A et al (2018) Safety and toxicology of magnolol and honokiol. Planta Med 84(16):1151\u20131164","journal-title":"Planta Med"},{"issue":"2","key":"4702_CR33","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jpag.2019.11.011","volume":"33","author":"JY Shim","year":"2020","unstructured":"Shim JY, Laufer MR (2020) Adolescent endometriosis: an update. J Pediatr Adolesc Gynecol 33(2):112\u2013119","journal-title":"J Pediatr Adolesc Gynecol"},{"issue":"10276","key":"4702_CR34","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/S0140-6736(21)00389-5","volume":"397","author":"HS Taylor","year":"2021","unstructured":"Taylor HS, Kotlyar AM, Flores VA (2021) Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet 397(10276):839\u2013852","journal-title":"Lancet"},{"issue":"5","key":"4702_CR35","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/nrendo.2013.255","volume":"10","author":"P Vercellini","year":"2014","unstructured":"Vercellini P et al (2014) Endometriosis: pathogenesis and treatment. Nat Rev Endocrinol 10(5):261\u2013275","journal-title":"Nat Rev Endocrinol"},{"issue":"11","key":"4702_CR36","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1080\/10286020.2023.2193695","volume":"25","author":"J Wang","year":"2023","unstructured":"Wang J et al (2023) Use of honokiol in lung cancer therapy: a mini review of its pharmacological mechanism. J Asian Nat Prod Res 25(11):1029\u20131037","journal-title":"J Asian Nat Prod Res"},{"issue":"9","key":"4702_CR37","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1038\/s41401-019-0240-x","volume":"40","author":"WD Wang","year":"2019","unstructured":"Wang WD (2019) Honokiol inhibits breast cancer cell metastasis by blocking EMT through modulation of Snail\/Slug protein translation. Acta Pharmacol Sin 40(9):1219\u20131227","journal-title":"Acta Pharmacol Sin"},{"issue":"9","key":"4702_CR38","doi-asserted-by":"publisher","first-page":"963","DOI":"10.2174\/15680096113136660102","volume":"13","author":"Y Wang","year":"2013","unstructured":"Wang Y et al (2013) The role of snail in EMT and tumorigenesis. Curr Cancer Drug Targets 13(9):963\u2013972","journal-title":"Curr Cancer Drug Targets"},{"issue":"1","key":"4702_CR39","first-page":"1","volume":"62","author":"Y Wang","year":"2016","unstructured":"Wang Y et al (2016)\u00a0Protective effect of honokiol against endometriosis in rats via\u00a0attenuating Survivin and Bcl-2: a mechanistic study. Cell Mol Biol (Noisy-le-grand) 62(1):1\u20135","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"issue":"6","key":"4702_CR40","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.21873\/invivo.13356","volume":"37","author":"Y Xie","year":"2023","unstructured":"Xie Y et al (2023) Metformin inhibits the estrogen-mediated epithelial-mesenchymal transition of ectopic endometrial stromal cells in endometriosis. In Vivo 37(6):2490\u20132497","journal-title":"In Vivo"},{"issue":"12","key":"4702_CR41","doi-asserted-by":"publisher","first-page":"8035","DOI":"10.1111\/jcmm.14668","volume":"23","author":"W Xiong","year":"2019","unstructured":"Xiong W et al (2019) E(2) -mediated EMT by activation of \u03b2-catenin\/snail signalling during the development of ovarian endometriosis. J Cell Mol Med 23(12):8035\u20138045","journal-title":"J Cell Mol Med"},{"issue":"25","key":"4702_CR42","doi-asserted-by":"publisher","first-page":"41679","DOI":"10.18632\/oncotarget.16472","volume":"8","author":"YM Yang","year":"2017","unstructured":"Yang YM, Yang WX (2017) Epithelial-to-mesenchymal transition in the development of endometriosis. Oncotarget 8(25):41679\u201341689","journal-title":"Oncotarget"},{"key":"4702_CR43","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/146136","volume":"2013","author":"CJ Yao","year":"2013","unstructured":"Yao CJ et al (2013) Honokiol eliminates human oral cancer stem-like cells accompanied with suppression of Wnt\/ \u03b2 -catenin signaling and apoptosis induction. Evid Based Complement Alternat Med 2013:146136","journal-title":"Evid Based Complement Alternat Med"},{"key":"4702_CR44","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/269138","volume":"2015","author":"J Yu","year":"2015","unstructured":"Yu J et al (2015) The effects and possible mechanisms of puerarin to treat endometriosis model rats. Evid Based Complement Alternat Med 2015:269138","journal-title":"Evid Based Complement Alternat Med"},{"issue":"6","key":"4702_CR45","doi-asserted-by":"publisher","first-page":"559","DOI":"10.2174\/1389450120666191024175727","volume":"21","author":"Y Yuan","year":"2020","unstructured":"Yuan Y et al (2020) Cardiovascular modulating effects of magnolol and honokiol, two polyphenolic compounds from traditional Chinese medicine-Magnolia officinalis. Curr Drug Targets 21(6):559\u2013572","journal-title":"Curr Drug Targets"},{"issue":"9","key":"4702_CR46","doi-asserted-by":"publisher","first-page":"6797","DOI":"10.18632\/oncotarget.3180","volume":"6","author":"M Zheng","year":"2015","unstructured":"Zheng M et al (2015) Snail and Slug collaborate on EMT and tumor metastasis through miR-101-mediated EZH2 axis in oral tongue squamous cell carcinoma. Oncotarget 6(9):6797\u20136810","journal-title":"Oncotarget"},{"issue":"2","key":"4702_CR47","doi-asserted-by":"publisher","first-page":"900","DOI":"10.3390\/cimb43020064","volume":"43","author":"A Zubrzycka","year":"2021","unstructured":"Zubrzycka A (2021) Circulating miRNAs related to epithelial-mesenchymal transitions (EMT) as the new molecular markers in endometriosis. Curr Issues Mol Biol 43(2):900\u2013916","journal-title":"Curr Issues Mol Biol"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04702-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04702-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04702-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:03:38Z","timestamp":1772780618000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04702-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,22]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["4702"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04702-x","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,22]]},"assertion":[{"value":"19 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All participants provided informed consent. The study complied with the Declaration of Helsinki and was approved by the Ethics Committee of the First Hospital of Hunan University of Chinese Medicine.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}]}}