{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T08:56:35Z","timestamp":1772009795614,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100018227","name":"National Research Foundation of Ukraine","doi-asserted-by":"publisher","award":["2020.01\/0517"],"award-info":[{"award-number":["2020.01\/0517"]}],"id":[{"id":"10.13039\/100018227","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s00210-025-04750-3","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T08:52:35Z","timestamp":1761123155000},"page":"4537-4546","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heart failure in old hypertensive rats is accompanied by the increase of neutrophil extracellular traps and myeloid-derived suppressor cells"],"prefix":"10.1007","volume":"399","author":[{"given":"V.","family":"Polishchuk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Pashevin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Dons\u2019koi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Lapikova-Bryhinska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Portnichenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Drevytska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6259-0518","authenticated-orcid":false,"given":"V.","family":"Nagibin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Dosenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"4750_CR1","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1007\/s40519-019-00729-1","volume":"25","author":"M Abbasalizad Farhangi","year":"2020","unstructured":"Abbasalizad Farhangi M, Vajdi M, Nikniaz L, Nikniaz Z (2020) The interaction between dietary inflammatory index and 6 P21 rs2010963 gene variants in metabolic syndrome. Eat Weight Disord 25:1049\u20131060. https:\/\/doi.org\/10.1007\/s40519-019-00729-1","journal-title":"Eat Weight Disord"},{"key":"4750_CR2","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/s41569-019-0315-x","volume":"17","author":"L Adamo","year":"2020","unstructured":"Adamo L, Rocha-Resende C, Prabhu SD, Mann DL (2020) Reappraising the role of inflammation in heart failure. Nat Rev Cardiol 17:269\u2013285. https:\/\/doi.org\/10.1038\/s41569-019-0315-x","journal-title":"Nat Rev Cardiol"},{"key":"4750_CR3","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aax7942","volume":"14","author":"F Apel","year":"2021","unstructured":"Apel F, Andreeva L, Knackstedt LS, Streeck R, Frese CK, Goosmann C, Hopfner KP, Zychlinsky A (2021) The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps. Sci Signal 14:eaax7942. https:\/\/doi.org\/10.1126\/scisignal.aax7942","journal-title":"Sci Signal"},{"key":"4750_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2019.103411","volume":"13","author":"EG Bentley","year":"2019","unstructured":"Bentley EG, Pugh G, Gledhill L, Flynn RJ (2019) An analysis of the immune compartment within bovine adipose tissue. Dev Comp Immunol 13:103411. https:\/\/doi.org\/10.1016\/j.dci.2019.103411","journal-title":"Dev Comp Immunol"},{"key":"4750_CR5","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1165\/rcmb.2017-0214OC","volume":"58","author":"AJ Bryant","year":"2018","unstructured":"Bryant AJ, Shenoy V, Fu C, Marek G, Lorentsen KJ, Herzog EL, Brantly ML, Avram D, Scott EW (2018) Myeloid-derived suppressor cells are necessary for development of pulmonary hypertension. Am J Respir Cell Mol Biol 58:170\u2013180. https:\/\/doi.org\/10.1165\/rcmb.2017-0214OC","journal-title":"Am J Respir Cell Mol Biol"},{"key":"4750_CR6","doi-asserted-by":"publisher","first-page":"26","DOI":"10.5411\/wji.v4.i1.26","volume":"4","author":"KR Crook","year":"2014","unstructured":"Crook KR, Liu P (2014) Role of myeloid-derived suppressor cells in autoimmune disease. World J Immunol 4:26\u201333. https:\/\/doi.org\/10.5411\/wji.v4.i1.26","journal-title":"World J Immunol"},{"key":"4750_CR7","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.cellimm.2015.02.005","volume":"295","author":"Y Dolen","year":"2015","unstructured":"Dolen Y, Gunaydin G, Esendagli G, Guc D (2015) Granulocytic subset of myeloid derived suppressor cells in rats with mammary carcinoma. Cell Immunol 295:29\u201335. https:\/\/doi.org\/10.1016\/j.cellimm.2015.02.005","journal-title":"Cell Immunol"},{"key":"4750_CR8","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1161\/CIRCRESAHA.116.309692","volume":"120","author":"Y D\u00f6ring","year":"2017","unstructured":"D\u00f6ring Y, Soehnlein O, Weber C (2017) Neutrophil extracellular traps in atherosclerosis and atherothrombosis. Circ Res 120:736\u2013743. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.309692","journal-title":"Circ Res"},{"key":"4750_CR9","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1161\/CIRCULATIONAHA.118.038010","volume":"139","author":"BM Everett","year":"2019","unstructured":"Everett BM, Cornel JH, Lainscak M, Anker SD, Abbate A, Thuren T, Libby P, Glynn RJ, Ridker PM (2019) Anti-inflammatory therapy with canakinumab for the prevention of hospitalization for heart failure. Circulation 139:1289\u20131299. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.118.038010","journal-title":"Circulation"},{"key":"4750_CR10","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1568457","volume":"2019","author":"JC Fern\u00e1ndez-Ruiz","year":"2019","unstructured":"Fern\u00e1ndez-Ruiz JC, Galindo-De \u00c1vila JC, Mart\u00ednez-Fierro ML, Garza-Veloz I, Cervantes-Villagrana AR, Valtierra-Alvarado MA, Serrano CJ, Garc\u00eda-Hern\u00e1ndez MH, Enciso-Moreno JA, Casta\u00f1eda-Delgado JE (2019) Myeloid-derived suppressor cells show different frequencies in diabetics and subjects with arterial hypertension. J Diabetes Res 2019:1568457. https:\/\/doi.org\/10.1155\/2019\/1568457","journal-title":"J Diabetes Res"},{"key":"4750_CR11","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","volume":"14","author":"C Franceschi","year":"2018","unstructured":"Franceschi C, Garagnani P, Parini P et al (2018) Inflammaging: a new immune\u2013metabolic viewpoint for age-related diseases. Nat Rev Endocrinol 14:576\u2013590. https:\/\/doi.org\/10.1038\/s41574-018-0059-4","journal-title":"Nat Rev Endocrinol"},{"key":"4750_CR12","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/nri2506","volume":"9","author":"DI Gabrilovich","year":"2009","unstructured":"Gabrilovich DI, Nagaraj S (2009) Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 9:162\u2013174. https:\/\/doi.org\/10.1038\/nri2506","journal-title":"Nat Rev Immunol"},{"key":"4750_CR13","doi-asserted-by":"publisher","first-page":"5705","DOI":"10.1007\/s00210-024-03602-w","volume":"398","author":"Y Goshovska","year":"2025","unstructured":"Goshovska Y, Pashevin D, Goncharov S, Lapikova-Bryhinska T, Lisovyi O, Nagibin V, Portnichenko G, Tumanovska L, Dosenko V (2025) Quercetin is a potential therapy for post-infarction NETosis formation. Naunyn Schmiedebergs Arch Pharmacol 398:5705\u20135712. https:\/\/doi.org\/10.1007\/s00210-024-03602-w","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"4750_CR14","doi-asserted-by":"publisher","unstructured":"Hazeldine J, Lord JM (2018) The Impact of Age on Neutrophil Extracellular Trap Formation. In: Fulop T, Franceschi C, Hirokawa K, Pawelec G (eds) Handbook of Immunosenescence, Springer, Cham. https:\/\/doi.org\/10.1007\/978-3-319-64597-1_102-1","DOI":"10.1007\/978-3-319-64597-1_102-1"},{"key":"4750_CR15","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s00395-019-0740-3","volume":"114","author":"TM Hofbauer","year":"2019","unstructured":"Hofbauer TM, Mangold A, Scherz T et al (2019) Neutrophil extracellular traps and fibrocytes in ST-segment elevation myocardial infarction. Basic Res Cardiol 114:33. https:\/\/doi.org\/10.1007\/s00395-019-0740-3","journal-title":"Basic Res Cardiol"},{"key":"4750_CR16","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1002\/hep.27841","volume":"62","author":"H Huang","year":"2015","unstructured":"Huang H, Tohme S, Al-Khafaji AB, Tai S, Loughran P, Chen L, Wang S, Kim J, Billiar T, Wang Y, Tsung A (2015) Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury. Hepatology 62:600\u2013614. https:\/\/doi.org\/10.1002\/hep.27841","journal-title":"Hepatology"},{"key":"4750_CR17","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.123.011057","volume":"17","author":"S Ichimura","year":"2024","unstructured":"Ichimura S, Misaka T, Ogawara R, Tomita Y, Anzai F, Sato Y, Miura S, Yokokawa T, Sato T, Oikawa M, Kobayashi A, Yoshihisa A, Takeishi Y (2024) Neutrophil extracellular traps in myocardial tissue drive cardiac dysfunction and adverse outcomes in patients with heart failure with dilated cardiomyopathy. Circ Heart Fail 17:e011057. https:\/\/doi.org\/10.1161\/CIRCHEARTFAILURE.123.011057","journal-title":"Circ Heart Fail"},{"key":"4750_CR18","unstructured":"Institute for Health Metrics and Evaluation (IHME) (2021) GBD compare. University of Washington, IHME, Seattle. Available from http:\/\/vizhub.healthdata.org\/gbd-compare. Accessed 05 Oct 2025"},{"key":"4750_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.584712","volume":"11","author":"N K\u00f6stlin-Gille","year":"2020","unstructured":"K\u00f6stlin-Gille N, Gille C (2020) Myeloid-derived suppressor cells in pregnancy and the neonatal period. Front Immunol 11:584712. https:\/\/doi.org\/10.3389\/fimmu.2020.584712","journal-title":"Front Immunol"},{"key":"4750_CR20","doi-asserted-by":"publisher","first-page":"6687","DOI":"10.1155\/2021\/6687096","volume":"2021","author":"S Ling","year":"2021","unstructured":"Ling S, Xu JW (2021) NETosis as a pathogenic factor for heart failure. Oxid Med Cell Longev 2021:6687\u20137096. https:\/\/doi.org\/10.1155\/2021\/6687096","journal-title":"Oxid Med Cell Longev"},{"key":"4750_CR21","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1755-1536-6-11","volume":"6","author":"Y Ma","year":"2013","unstructured":"Ma Y, Yabluchanskiy A, Lindsey ML (2013) Neutrophil roles in left ventricular remodeling following myocardial infarction. Fibrogenesis Tissue Repair 6:11. https:\/\/doi.org\/10.1186\/1755-1536-6-11","journal-title":"Fibrogenesis Tissue Repair"},{"issue":"1","key":"4750_CR22","doi-asserted-by":"publisher","first-page":"23","DOI":"10.5301\/jn.2010.4729","volume":"24","author":"F Montecucco","year":"2011","unstructured":"Montecucco F, Pende A, Quercioli A, Mach F (2011) Inflammation in the pathophysiology of essential hypertension. J Nephrol 24(1):23\u201334. https:\/\/doi.org\/10.5301\/jn.2010.4729","journal-title":"J Nephrol"},{"key":"4750_CR23","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.apsb.2021.05.011","volume":"12","author":"PK Oduro","year":"2022","unstructured":"Oduro PK, Zheng X, Wei J, Yang Y, Wang Y, Zhang H, Liu E, Gao X, Du M, Wang Q (2022) The cGAS-STING signaling in cardiovascular and metabolic diseases: future novel target option for pharmacotherapy. Acta Pharm Sin B 12:50\u201375. https:\/\/doi.org\/10.1016\/j.apsb.2021.05.011","journal-title":"Acta Pharm Sin B"},{"key":"4750_CR24","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1016\/j.jvs.2013.02.241","volume":"58","author":"R Oklu","year":"2013","unstructured":"Oklu R, Albadawi H, Jones JE, Yoo HJ, Watkins MTJ (2013) Reduced hind limb ischemia-reperfusion injury in Toll-like receptor-4 mutant mice is associated with decreased neutrophil extracellular traps. Vasc Surg 58:1627\u20131636. https:\/\/doi.org\/10.1016\/j.jvs.2013.02.241","journal-title":"Vasc Surg"},{"key":"4750_CR25","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.canlet.2021.12.027","volume":"529","author":"S Ortiz-Espinosa","year":"2022","unstructured":"Ortiz-Espinosa S, Morales X, Senent Y et al (2022) Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis. Cancer Lett 529:70\u201384. https:\/\/doi.org\/10.1016\/j.canlet.2021.12.027","journal-title":"Cancer Lett"},{"key":"4750_CR26","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1159\/000440982","volume":"82","author":"DO Pashevin","year":"2015","unstructured":"Pashevin DO, Nagibin VS, Tumanovska LV, Moibenko AA, Dosenko VE (2015) Proteasome inhibition diminishes the formation of neutrophil extracellular traps and prevents the death of cardiomyocytes in coculture with activated neutrophils during anoxia-reoxygenation. Pathobiology 82:290\u2013298. https:\/\/doi.org\/10.1159\/000440982","journal-title":"Pathobiology"},{"key":"4750_CR27","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.tins.2020.10.008","volume":"44","author":"BD Paul","year":"2021","unstructured":"Paul BD, Snyder SH, Bohr VA (2021) Signaling by cGAS-STING in neurodegeneration, neuroinflammation, and aging. Trends Neurosci 44:83\u201396. https:\/\/doi.org\/10.1016\/j.tins.2020.10.008","journal-title":"Trends Neurosci"},{"issue":"23","key":"4750_CR28","doi-asserted-by":"publisher","first-page":"2754","DOI":"10.2174\/0929867322666150420104727","volume":"22","author":"P Pietri","year":"2015","unstructured":"Pietri P, Vlachopoulos C, Tousoulis D (2015) Inflammation and arterial hypertension: from pathophysiological links to risk prediction. Curr Med Chem 22(23):2754\u20132761. https:\/\/doi.org\/10.2174\/0929867322666150420104727","journal-title":"Curr Med Chem"},{"issue":"7","key":"4750_CR29","doi-asserted-by":"publisher","first-page":"485","DOI":"10.3389\/fimmu.2016.00485","volume":"14","author":"F Pratesi","year":"2016","unstructured":"Pratesi F, Prediletto E, Bombardieri M, Migliorini P, Corsiero E (2016) Netosis as source of autoantigens in rheumatoid arthritis. Front Immunol 14(7):485. https:\/\/doi.org\/10.3389\/fimmu.2016.00485","journal-title":"Front Immunol"},{"key":"4750_CR30","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.kint.2017.08.014","volume":"93","author":"WM Raup-Konsavage","year":"2018","unstructured":"Raup-Konsavage WM, Wang Y, Wang WW, Feliers D, Ruan H, Reeves WB (2018) Neutrophil peptidyl arginine deiminase-4 has a pivotal role in ischemia\/reperfusion-induced acute kidney injury. Kidney Int 93:365\u2013374. https:\/\/doi.org\/10.1016\/j.kint.2017.08.014","journal-title":"Kidney Int"},{"key":"4750_CR31","doi-asserted-by":"publisher","DOI":"10.1172\/JCI156453","volume":"132","author":"DF Riascos-Bernal","year":"2022","unstructured":"Riascos-Bernal DF, Sibinga NS (2022) Neutrophil extracellular traps in cardiac hypertrophy: a KLF2 perspective. J Clin Invest 132:e156453. https:\/\/doi.org\/10.1172\/JCI156453","journal-title":"J Clin Invest"},{"key":"4750_CR32","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1007\/s00018-019-03048-x","volume":"76","author":"A Salminen","year":"2019","unstructured":"Salminen A, Kaarniranta K, Kauppinen A (2019) Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency. Cell Mol Life Sci 76:1901\u20131918. https:\/\/doi.org\/10.1007\/s00018-019-03048-x","journal-title":"Cell Mol Life Sci"},{"issue":"10","key":"4750_CR33","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1161\/CIRCRESAHA.115.306539","volume":"117","author":"KH Shah","year":"2015","unstructured":"Shah KH, Shi P, Giani JF, Janjulia T, Bernstein EA, Li Y, Zhao T, Harrison DG, Bernstein KE, Shen XZ (2015) Myeloid suppressor cells accumulate and regulate blood pressure in hypertension. Circ Res 117(10):858\u2013869. https:\/\/doi.org\/10.1161\/CIRCRESAHA.115.306539","journal-title":"Circ Res"},{"key":"4750_CR34","doi-asserted-by":"publisher","DOI":"10.1172\/JCI147191","volume":"132","author":"X Tang","year":"2022","unstructured":"Tang X, Wang P, Zhang R, Watanabe I, Chang E, Vinayachandran V, Nayak L, Lapping S, Liao S, Madera A, Sweet DR, Luo J, Fei J, Jeong HW, Adams RH, Zhang T, Liao X, Jain MK (2022) KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression. J Clin Invest 132:e147191. https:\/\/doi.org\/10.1172\/JCI147191","journal-title":"J Clin Invest"},{"key":"4750_CR35","doi-asserted-by":"publisher","first-page":"531","DOI":"10.3389\/fphar.2019.00531","volume":"10","author":"EPC van der Vorst","year":"2019","unstructured":"van der Vorst EPC, Peters LJF, M\u00fcller M, Gencer S, Yan Y, Weber C, D\u00f6ring Y (2019) G-protein coupled receptor targeting on myeloid cells in atherosclerosis. Front Pharmacol 10:531. https:\/\/doi.org\/10.3389\/fphar.2019.00531","journal-title":"Front Pharmacol"},{"key":"4750_CR36","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.3389\/fimmu.2018.01310","volume":"9","author":"R Weber","year":"2018","unstructured":"Weber R, Fleming V, Hu X, Nagibin V, Groth C, Altevogt P, Utikal J, Umansky V (2018) Myeloid-derived suppressor cells hinder the anti-cancer activity of immune checkpoint inhibitors. Front Immunol 9:1310. https:\/\/doi.org\/10.3389\/fimmu.2018.01310","journal-title":"Front Immunol"},{"key":"4750_CR37","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1378\/chest.11-0205","volume":"141","author":"ME Yeager","year":"2012","unstructured":"Yeager ME, Nguyen CM, Belchenko DD, Colvin KL, Takatsuki S, Ivy DD, Stenmark KR (2012) Circulating myeloid-derived suppressor cells are increased and activated in pulmonary hypertension. Chest 141:944\u2013952. https:\/\/doi.org\/10.1378\/chest.11-0205","journal-title":"Chest"},{"key":"4750_CR38","doi-asserted-by":"publisher","first-page":"3634","DOI":"10.1128\/IAI.00668-12","volume":"80","author":"C Zhang","year":"2012","unstructured":"Zhang C, Lei GS, Shao S, Jung HW, Durant PJ, Lee CH (2012) Accumulation of myeloid-derived suppressor cells in the lungs during pneumocystis pneumonia. Infect Immun 80:3634\u20133641. https:\/\/doi.org\/10.1128\/IAI.00668-12","journal-title":"Infect Immun"},{"key":"4750_CR39","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1161\/CIRCULATIONAHA.117.030811","volume":"138","author":"L Zhou","year":"2018","unstructured":"Zhou L, Miao K, Yin B, Li H, Fan J, Zhu Y, Ba H, Zhang Z, Chen F, Wang J, Zhao C, Li Z, Wang DW (2018) Cardioprotective role of myeloid-derived suppressor cells in heart failure. Circulation 138:181\u2013197. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.117.030811","journal-title":"Circulation"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04750-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04750-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04750-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T07:58:44Z","timestamp":1772006324000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04750-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,22]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["4750"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04750-3","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,22]]},"assertion":[{"value":"14 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All of the manipulations with laboratory animals were performed in accordance with the guidelines of the Declaration of Helsinki, Directive 2010\/63\/EU of the European Parliament and of the Council on the protection of animals used for scientific purposes (22.09.2010) and Document \u21163447-IV (2006) of the Parliament of Ukraine \u201cOn the Protection of Animals from Brutal Treatment.\u201d The protocol was approved by the Institutional Committee on Bioethics.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}