{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:03:45Z","timestamp":1782889425636,"version":"3.54.5"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["Grant No. 2016YFD0400500"],"award-info":[{"award-number":["Grant No. 2016YFD0400500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Science and Technology Reform and Development Special Projec","award":["Grant No. 106001000000150012"],"award-info":[{"award-number":["Grant No. 106001000000150012"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s00210-025-04757-w","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:26:33Z","timestamp":1761708393000},"page":"5137-5155","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Malvidin-3,5-O-diglucoside derived from spine grape (Vitis davidii) inhibits fructose-induced lipid accumulation in HepG2 cells: beneficial effects on MASLD treatment"],"prefix":"10.1007","volume":"399","author":[{"given":"Tiantian","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuliang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"4757_CR1","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1002\/hep.25741","volume":"56","author":"MF Abdelmalek","year":"2012","unstructured":"Abdelmalek MF, Lazo M, Horska A et al (2012) Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes. Hepatology 56:952\u2013960. https:\/\/doi.org\/10.1002\/hep.25741","journal-title":"Hepatology"},{"key":"4757_CR2","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1002\/hep.23535","volume":"51","author":"MF Abdelmalek","year":"2010","unstructured":"Abdelmalek MF, Suzuki A, Guy C et al (2010) Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. Hepatology 51:1961\u20131971. https:\/\/doi.org\/10.1002\/hep.23535","journal-title":"Hepatology"},{"key":"4757_CR3","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.nut.2013.11.016","volume":"30","author":"JM Andrade","year":"2014","unstructured":"Andrade JM, Para\u00edso AF, de Oliveira MV et al (2014) Resveratrol attenuates hepatic steatosis in high-fat fed mice by decreasing lipogenesis and inflammation. Nutrition 30:915\u2013919. https:\/\/doi.org\/10.1016\/j.nut.2013.11.016","journal-title":"Nutrition"},{"key":"4757_CR4","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.3390\/nu13062003","volume":"13","author":"R Araki","year":"2021","unstructured":"Araki R, Yada A, Ueda H et al (2021) Differences in the effects of anthocyanin supplementation on glucose and lipid metabolism according to the structure of the main anthocyanin: a meta-analysis of randomized controlled trials. Nutrients 13:2003. https:\/\/doi.org\/10.3390\/nu13062003","journal-title":"Nutrients"},{"key":"4757_CR5","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.foodchem.2016.06.050","volume":"213","author":"JM Avizcuri","year":"2016","unstructured":"Avizcuri JM, S\u00e1enz-Navajas MP, Ech\u00e1varri JF et al (2016) Evaluation of the impact of initial red wine composition on changes in color and anthocyanin content during bottle storage. Food Chem 213:123\u2013134. https:\/\/doi.org\/10.1016\/j.foodchem.2016.06.050","journal-title":"Food Chem"},{"key":"4757_CR6","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/j.jhep.2011.08.025","volume":"56","author":"LP Bechmann","year":"2012","unstructured":"Bechmann LP, Hannivoort RA, Gerken G et al (2012) The interaction of hepatic lipid and glucose metabolism in liver diseases. J Hepatol 56:952\u2013964. https:\/\/doi.org\/10.1016\/j.jhep.2011.08.025","journal-title":"J Hepatol"},{"key":"4757_CR7","doi-asserted-by":"publisher","first-page":"174078","DOI":"10.1016\/j.ejphar.2021.174078","volume":"901","author":"O Bedi","year":"2021","unstructured":"Bedi O, Srivastava N, Parsad D et al (2021) Fatty acid synthase inhibition ameliorates diabetes induced liver injury in rodent experimental model. Eur J Pharmacol 901:174078. https:\/\/doi.org\/10.1016\/j.ejphar.2021.174078","journal-title":"Eur J Pharmacol"},{"key":"4757_CR8","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.jcmgh.2020.09.004","volume":"11","author":"K Chella Krishnan","year":"2021","unstructured":"Chella Krishnan K, Floyd RR, Sabir S et al (2021) Liver pyruvate kinase promotes NAFLD\/NASH in both mice and humans in a sex-specific manner. Cell Mol Gastroenterol Hepatol 11:389\u2013406. https:\/\/doi.org\/10.1016\/j.jcmgh.2020.09.004","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"4757_CR9","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s00394-010-0117-8","volume":"50","author":"KW Cho","year":"2011","unstructured":"Cho KW, Kim YO, Andrade JE et al (2011) Dietary naringenin increases hepatic peroxisome proliferators-activated receptor \u03b1 protein expression and decreases plasma triglyceride and adiposity in rats. Eur J Nutr 50:81\u201388. https:\/\/doi.org\/10.1007\/s00394-010-0117-8","journal-title":"Eur J Nutr"},{"key":"4757_CR10","doi-asserted-by":"publisher","first-page":"4825949","DOI":"10.1155\/2019\/4825949","volume":"2019","author":"Q Chu","year":"2019","unstructured":"Chu Q, Zhang S, Chen M et al (2019) Cherry anthocyanins regulate NAFLD by promoting autophagy pathway. Oxid Med Cell Longev 2019:4825949. https:\/\/doi.org\/10.1155\/2019\/4825949","journal-title":"Oxid Med Cell Longev"},{"key":"4757_CR11","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1053\/j.gastro.2012.02.003","volume":"142","author":"K Cusi","year":"2012","unstructured":"Cusi K (2012) Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications. Gastroenterology 142:711\u2013725. https:\/\/doi.org\/10.1053\/j.gastro.2012.02.003","journal-title":"Gastroenterology"},{"key":"4757_CR12","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3390\/nu12020356","volume":"12","author":"A Czumaj","year":"2020","unstructured":"Czumaj A, \u015aledzi\u0144ski T (2020) Biological role of unsaturated fatty acid desaturases in health and disease. Nutrients 12:356. https:\/\/doi.org\/10.3390\/nu12020356","journal-title":"Nutrients"},{"key":"4757_CR13","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1097\/MCO.0b013e328042ba90","volume":"10","author":"J Delarue","year":"2007","unstructured":"Delarue J, Magnan C (2007) Free fatty acids and insulin resistance. Curr Opin Clin Nutr Metab Care 10:142\u2013148. https:\/\/doi.org\/10.1097\/MCO.0b013e328042ba90","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"4757_CR14","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1172\/JCI25256","volume":"115","author":"R Dentin","year":"2005","unstructured":"Dentin R, Benhamed F, P\u00e9gorier JP et al (2005) Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation. J Clin Invest 115:2843\u20132854. https:\/\/doi.org\/10.1172\/JCI25256","journal-title":"J Clin Invest"},{"key":"4757_CR15","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1369\/jhc.2009.953190","volume":"57","author":"CP Diggle","year":"2009","unstructured":"Diggle CP, Shires M, Leitch D et al (2009) Ketohexokinase: expression and localization of the principal fructose-metabolizing enzyme. J Histochem Cytochem 57:763\u2013774. https:\/\/doi.org\/10.1369\/jhc.2009.953190","journal-title":"J Histochem Cytochem"},{"key":"4757_CR16","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1053\/j.gastro.2019.11.312","volume":"158","author":"M Eslam","year":"2020","unstructured":"Eslam M, Sanyal AJ, George J (2020) MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease. Gastroenterology 158:1999\u20132014. https:\/\/doi.org\/10.1053\/j.gastro.2019.11.312","journal-title":"Gastroenterology"},{"key":"4757_CR17","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.3390\/nu11112586","volume":"11","author":"M Fan","year":"2019","unstructured":"Fan M, Choi YJ, Tang Y et al (2019) Efficacy and mechanism of polymerized anthocyanin from grape-skin extract on high-fat-diet-induced nonalcoholic fatty liver disease. Nutrients 11:2586. https:\/\/doi.org\/10.3390\/nu11112586","journal-title":"Nutrients"},{"key":"4757_CR18","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1463-1326.2010.01275.x","volume":"12","author":"P Ferr\u00e9","year":"2010","unstructured":"Ferr\u00e9 P, Foufelle F (2010) Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c. Diabetes Obes Metab 12:83\u201392. https:\/\/doi.org\/10.1111\/j.1463-1326.2010.01275.x","journal-title":"Diabetes Obes Metab"},{"key":"4757_CR19","doi-asserted-by":"publisher","first-page":"814951","DOI":"10.3389\/fmed.2021.814951","volume":"8","author":"M Frid\u00e9n","year":"2022","unstructured":"Frid\u00e9n M, Rosqvist F, Ahlstr\u00f6m H et al (2022) Hepatic unsaturated fatty acids are linked to lower degree of fibrosis in non-alcoholic fatty liver disease. Front Med 8:814951. https:\/\/doi.org\/10.3389\/fmed.2021.814951","journal-title":"Front Med"},{"key":"4757_CR20","doi-asserted-by":"publisher","first-page":"934396","DOI":"10.1155\/2012\/934396","volume":"2012","author":"M Fuchs","year":"2012","unstructured":"Fuchs M (2012) Non-alcoholic fatty liver disease: the bile acid-activated farnesoid x receptor as an emerging treatment target. J Lipids 2012:934396. https:\/\/doi.org\/10.1155\/2012\/934396","journal-title":"J Lipids"},{"key":"4757_CR21","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.15252\/emmm.201404046","volume":"6","author":"L Goedeke","year":"2014","unstructured":"Goedeke L, Salerno A, Ram\u00edrez CM et al (2014) Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice. EMBO Mol Med 6:1133\u20131141. https:\/\/doi.org\/10.15252\/emmm.201404046","journal-title":"EMBO Mol Med"},{"key":"4757_CR22","doi-asserted-by":"publisher","first-page":"126398","DOI":"10.1016\/j.foodchem.2020.126398","volume":"317","author":"FL Han","year":"2020","unstructured":"Han FL, Oliveira H, Br\u00e1s NF et al (2020) In vitro gastrointestinal absorption of red wine anthocyanins - Impact of structural complexity and phase II metabolization. Food Chem 317:126398. https:\/\/doi.org\/10.1016\/j.foodchem.2020.126398","journal-title":"Food Chem"},{"key":"4757_CR23","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.tifs.2018.11.025","volume":"83","author":"FL Han","year":"2019","unstructured":"Han FL, Yang P, Wang H et al (2019) Digestion and absorption of red grape and wine anthocyanins through the gastrointestinal tract. Trends Food Sci Technol 83:211\u2013224. https:\/\/doi.org\/10.1016\/j.tifs.2018.11.025","journal-title":"Trends Food Sci Technol"},{"key":"4757_CR24","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature10986","volume":"484","author":"MA Herman","year":"2021","unstructured":"Herman MA, Peroni OD, Villoria J et al (2021) A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Nature 484:333\u2013338. https:\/\/doi.org\/10.1038\/nature10986","journal-title":"Nature"},{"key":"4757_CR25","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1507\/endocrj.K07E-110","volume":"55","author":"K Iizuka","year":"2008","unstructured":"Iizuka K, Horikawa Y (2008) ChREBP: a glucose-activated transcription factor involved in the development of metabolic syndrome. Endocr J 55:617\u2013624. https:\/\/doi.org\/10.1507\/endocrj.K07E-110","journal-title":"Endocr J"},{"key":"4757_CR26","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jab.2014.09.003","volume":"12","author":"M Iriti","year":"2014","unstructured":"Iriti M, Varoni EM (2014) Cardioprotective effects of moderate red wine consumption: polyphenols vs. ethanol. J Appl Biomed 12:193\u2013202. https:\/\/doi.org\/10.1016\/j.jab.2014.09.003","journal-title":"J Appl Biomed"},{"key":"4757_CR27","doi-asserted-by":"publisher","first-page":"4320","DOI":"10.1073\/pnas.1119908109","volume":"109","author":"T Ishimoto","year":"2012","unstructured":"Ishimoto T, Lanaspa MA, Le MT et al (2012) Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. Proc Natl Acad Sci U S A 109:4320\u20134325. https:\/\/doi.org\/10.1073\/pnas.1119908109","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4757_CR28","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1002\/hep.26594","volume":"58","author":"T Ishimoto","year":"2013","unstructured":"Ishimoto T, Lanaspa MA, Rivard CJ et al (2013) High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology 58:1632\u20131643. https:\/\/doi.org\/10.1002\/hep.26594","journal-title":"Hepatology"},{"key":"4757_CR29","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/347645a0","volume":"347","author":"I Issemann","year":"1990","unstructured":"Issemann I, Green S (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347:645\u2013650. https:\/\/doi.org\/10.1038\/347645a0","journal-title":"Nature"},{"key":"4757_CR30","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1080\/10408398.2018.1491022","volume":"59","author":"X Jiang","year":"2019","unstructured":"Jiang X, Li X, Zhu C et al (2019) The target cells of anthocyanins in metabolic syndrome. Crit Rev Food Sci Nutr 59:921\u2013946. https:\/\/doi.org\/10.1080\/10408398.2018.1491022","journal-title":"Crit Rev Food Sci Nutr"},{"key":"4757_CR31","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1021\/acs.jafc.9b06916","volume":"68","author":"T Jiang","year":"2020","unstructured":"Jiang T, Shuai X, Li J et al (2020) Protein-bound anthocyanin compounds of purple sweet potato ameliorate hyperglycemia by regulating hepatic glucose metabolism in high-fat diet\/streptozotocin-induced diabetic mice. J Agric Food Chem 68:1596\u20131608. https:\/\/doi.org\/10.1021\/acs.jafc.9b06916","journal-title":"J Agric Food Chem"},{"key":"4757_CR32","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1007\/s00535-013-0758-5","volume":"48","author":"Y Kawano","year":"2013","unstructured":"Kawano Y, Cohen DE (2013) Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease. J Gastroenterol 48:434\u2013441. https:\/\/doi.org\/10.1007\/s00535-013-0758-5","journal-title":"J Gastroenterol"},{"key":"4757_CR33","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s11130-015-0514-5","volume":"70","author":"SG Lee","year":"2015","unstructured":"Lee SG, Vance TM, Nam TG et al (2015) Contribution of anthocyanin composition to total antioxidant capacity of berries. Plant Foods Hum Nutr 70:427\u2013432. https:\/\/doi.org\/10.1007\/s11130-015-0514-5","journal-title":"Plant Foods Hum Nutr"},{"key":"4757_CR34","doi-asserted-by":"publisher","first-page":"6621644","DOI":"10.1155\/2021\/6621644","volume":"2021","author":"HY Li","year":"2021","unstructured":"Li HY, Gan RY, Shang A et al (2021) Plant-based foods and their bioactive compounds on fatty liver disease: effects, mechanisms, and clinical application. Oxid Med Cell Longev 2021:6621644. https:\/\/doi.org\/10.1155\/2021\/6621644","journal-title":"Oxid Med Cell Longev"},{"key":"4757_CR35","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/bph.15083","volume":"177","author":"X Li","year":"2020","unstructured":"Li X, Shi Z, Zhu Y et al (2020) Cyanidin-3-O-glucoside improves non-alcoholic fatty liver disease by promoting PINK1-mediated mitophagy in mice. Br J Pharmacol 177:591\u20133607. https:\/\/doi.org\/10.1111\/bph.15083","journal-title":"Br J Pharmacol"},{"key":"4757_CR36","doi-asserted-by":"publisher","first-page":"7726","DOI":"10.1021\/acs.jafc.9b02523","volume":"67","author":"W Li","year":"2019","unstructured":"Li W, Yang H, Zhao Q et al (2019) Polyphenol-rich loquat fruit extract prevents fructose-induced nonalcoholic fatty liver disease by modulating glycometabolism, lipometabolism, oxidative stress, inflammation, the intestinal barrier and the gut microbiota in mice. J Agric Food Chem 67:7726\u20137737. https:\/\/doi.org\/10.1021\/acs.jafc.9b02523","journal-title":"J Agric Food Chem"},{"key":"4757_CR37","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nrgastro.2010.41","volume":"7","author":"JS Lim","year":"2010","unstructured":"Lim JS, Mietus-Snyder M, Valente A et al (2010) The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome. Nat Rev Gastroenterol Hepatol 7:251\u2013264. https:\/\/doi.org\/10.1038\/nrgastro.2010.41","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"4757_CR38","doi-asserted-by":"publisher","first-page":"111967","DOI":"10.1016\/j.cellsig.2025.111967","volume":"134","author":"ZJ Liu","year":"2025","unstructured":"Liu ZJ, Le YF, Lu DZ (2025) PKM2: a novel helmsman of lipid metabolism. Cell Signal 134:111967. https:\/\/doi.org\/10.1016\/j.cellsig.2025.111967","journal-title":"Cell Signal"},{"key":"4757_CR39","doi-asserted-by":"publisher","first-page":"12254","DOI":"10.1021\/jf203136j","volume":"59","author":"Y Liu","year":"2011","unstructured":"Liu Y, Wang D, Zhang D et al (2011) Inhibitory effect of blueberry polyphenolic compounds on oleic acid-induced hepatic steatosis in vitro. J Agric Food Chem 59:12254\u201312263. https:\/\/doi.org\/10.1021\/jf203136j","journal-title":"J Agric Food Chem"},{"key":"4757_CR40","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/nrgastro.2013.171","volume":"10","author":"R Loomba","year":"2013","unstructured":"Loomba R, Sanyal AJ (2013) The global NAFLD epidemic. Nat Rev Gastroenterol Hepatol 10:686\u2013690. https:\/\/doi.org\/10.1038\/nrgastro.2013.171","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"4757_CR41","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/ng.3714","volume":"49","author":"LA Lotta","year":"2017","unstructured":"Lotta LA, Gulati P, Day FR et al (2017) Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. Nat Genet 49:17\u201326. https:\/\/doi.org\/10.1038\/ng.3714","journal-title":"Nat Genet"},{"key":"4757_CR42","doi-asserted-by":"publisher","first-page":"3339","DOI":"10.3390\/nu12113339","volume":"12","author":"T Ma\u0161ek","year":"2020","unstructured":"Ma\u0161ek T, Bari\u0161i\u0107 J, Micek V et al (2020) Cafeteria diet and high-fructose rodent models of NAFLD differ in the metabolism of important PUFA and palmitoleic acid without additional influence of sex. Nutrients 12:3339. https:\/\/doi.org\/10.3390\/nu12113339","journal-title":"Nutrients"},{"key":"4757_CR43","doi-asserted-by":"publisher","first-page":"e613\u2013621","DOI":"10.1152\/ajpendo.00296.2017","volume":"315","author":"L Meoli","year":"2018","unstructured":"Meoli L, Gupta NK, Saeidi N et al (2018) Nonalcoholic fatty liver disease and gastric bypass surgery regulate serum and hepatic levels of pyruvate kinase isoenzyme M2. Am J Physiol Endocrinol Metab 315:e613\u2013621. https:\/\/doi.org\/10.1152\/ajpendo.00296.2017","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"4757_CR44","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.jhep.2016.12.025","volume":"66","author":"A Mosca","year":"2017","unstructured":"Mosca A, Nobili V, De Vito R et al (2017) Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents. J Hepatol 66:1031\u20131036. https:\/\/doi.org\/10.1016\/j.jhep.2016.12.025","journal-title":"J Hepatol"},{"key":"4757_CR45","doi-asserted-by":"publisher","first-page":"861664","DOI":"10.3389\/fnut.2022.861664","volume":"9","author":"E Murru","year":"2022","unstructured":"Murru E, Manca C, Carta G et al (2022) Impact of dietary palmitic acid on lipid metabolism. Front Nutr 9:861664. https:\/\/doi.org\/10.3389\/fnut.2022.861664","journal-title":"Front Nutr"},{"key":"4757_CR46","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s12263-015-0455-5","volume":"10","author":"S Park","year":"2015","unstructured":"Park S, Kang S, Jeong DY et al (2015) Cyanidin and malvidin in aqueous extracts of black carrots fermented with Aspergillus oryzae prevent the impairment of energy, lipid and glucose metabolism in estrogen-deficient rats by AMPK activation. Genes Nutr 10:455. https:\/\/doi.org\/10.1007\/s12263-015-0455-5","journal-title":"Genes Nutr"},{"key":"4757_CR47","doi-asserted-by":"publisher","first-page":"2663","DOI":"10.1021\/jf1043508","volume":"59","author":"CH Peng","year":"2011","unstructured":"Peng CH, Liu LK, Chuang CM et al (2011) Mulberry water extracts possess an anti-obesity effect and ability to inhibit hepatic lipogenesis and promote lipolysis. J Agric Food Chem 59:2663\u20132671. https:\/\/doi.org\/10.1021\/jf1043508","journal-title":"J Agric Food Chem"},{"key":"4757_CR48","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.cmet.2016.06.005","volume":"24","author":"KF Petersen","year":"2016","unstructured":"Petersen KF, Befroy DE, Dufour S et al (2016) Assessment of hepatic mitochondrial oxidation and pyruvate cycling in NAFLD by 13c magnetic resonance spectroscopy. Cell Metab 24:167\u2013171. https:\/\/doi.org\/10.1016\/j.cmet.2016.06.005","journal-title":"Cell Metab"},{"key":"4757_CR49","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3390\/nu13010015","volume":"13","author":"D Ristic-Medic","year":"2020","unstructured":"Ristic-Medic D, Kovacic M, Takic M et al (2020) Calorie-restricted mediterranean and low-fat diets affect fatty acid status in individuals with nonalcoholic fatty liver disease. Nutrients 13:15. https:\/\/doi.org\/10.3390\/nu13010015","journal-title":"Nutrients"},{"key":"4757_CR50","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1016\/j.jff.2015.06.018","volume":"18","author":"F Shahidi","year":"2015","unstructured":"Shahidi F, Ambigaipalan P (2015) Phenolics and polyphenolics in foods, beverages and spices: antioxidant activity and health effects-a review. J Funct Foods 18:820\u2013897. https:\/\/doi.org\/10.1016\/j.jff.2015.06.018","journal-title":"J Funct Foods"},{"key":"4757_CR51","doi-asserted-by":"publisher","first-page":"4059","DOI":"10.1172\/JCI94585","volume":"127","author":"S Softic","year":"2017","unstructured":"Softic S, Gupta MK, Wang GX et al (2017) Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. J Clin Invest 127:4059\u20134074. https:\/\/doi.org\/10.1172\/JCI94585","journal-title":"J Clin Invest"},{"key":"4757_CR52","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/s41586-021-03827-2","volume":"597","author":"SR Taylor","year":"2021","unstructured":"Taylor SR, Ramsamooj S, Liang RJ et al (2021) Dietary fructose improves intestinal cell survival and nutrient absorption. Nature 597:263\u2013267. https:\/\/doi.org\/10.1038\/s41586-021-03827-2","journal-title":"Nature"},{"key":"4757_CR53","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1038\/s42255-020-0261-2","volume":"2","author":"J Todoric","year":"2020","unstructured":"Todoric J, Di Caro G, Reibe S et al (2020) Fructose stimulated de novo lipogenesis is promoted by inflammation. Nat Metab 2:1034\u20131045. https:\/\/doi.org\/10.1038\/s42255-020-0261-2","journal-title":"Nat Metab"},{"key":"4757_CR54","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/hep.28431","volume":"64","author":"ZM Younossi","year":"2016","unstructured":"Younossi ZM, Koenig AB, Abdelatif D et al (2016) Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology 64:73\u201384. https:\/\/doi.org\/10.1002\/hep.28431","journal-title":"Hepatology"},{"key":"4757_CR55","doi-asserted-by":"publisher","first-page":"111957","DOI":"10.1016\/j.fct.2020.111957","volume":"148","author":"X Zhang","year":"2021","unstructured":"Zhang X, Kan H, Liu Y et al (2021) Plumbagin induces Ishikawa cell cycle arrest, autophagy, and apoptosis via the PI3K\/Akt signaling pathway in endometrial cancer. Food Chem Toxicol 148:111957. https:\/\/doi.org\/10.1016\/j.fct.2020.111957","journal-title":"Food Chem Toxicol"},{"key":"4757_CR56","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1002\/hep.30507","volume":"70","author":"Y Zheng","year":"2019","unstructured":"Zheng Y, Qu H, Xiong X et al (2019) Deficiency of mitochondrial glycerol 3-phosphate dehydrogenase contributes to hepatic steatosis. Hepatology 70:84\u201397. https:\/\/doi.org\/10.1002\/hep.30507","journal-title":"Hepatology"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04757-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04757-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04757-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T03:06:46Z","timestamp":1775099206000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04757-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,29]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["4757"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04757-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7215499\/v1","asserted-by":"object"}]},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,29]]},"assertion":[{"value":"25 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval\u00a0"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}