{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T16:59:44Z","timestamp":1782320384003,"version":"3.54.5"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s00210-025-04822-4","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T07:37:06Z","timestamp":1765179426000},"page":"7377-7391","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The hepatoprotective role of piperazine ferulate against cisplatin-induced hepatotoxicity in rats: insights into the Keap1\/Nrf-2\/HO-1 signaling and inflammatory pathways"],"prefix":"10.1007","volume":"399","author":[{"given":"Hayam Ali","family":"AlRasheed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya Y.","family":"Gawish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khlood Mohammad","family":"Aldossary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa A.","family":"Alsharif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada A.","family":"Alsaleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabab Ahmed","family":"Rasheed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia","family":"Zaafar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"4822_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115794","volume":"216","author":"BA Abdel-Wahab","year":"2023","unstructured":"Abdel-Wahab BA, El-Shoura EAM, Shafiuddin Habeeb M, Zafaar D (2023) Febuxostat alleviates arsenic trioxide-induced renal injury in rats: insights on the crosstalk between NLRP3\/TLR4, Sirt-1\/NF-\u03baB\/TGF-\u03b2 signaling pathways, and miR-23b-3p, miR-181a-5b expression. Biochem Pharmacol 216:115794. https:\/\/doi.org\/10.1016\/j.bcp.2023.115794","journal-title":"Biochem Pharmacol"},{"issue":"6","key":"4822_CR2","doi-asserted-by":"publisher","first-page":"6719","DOI":"10.1007\/s00210-024-03654-y","volume":"398","author":"BA Abdel-Wahab","year":"2024","unstructured":"Abdel-Wahab BA, El-Shoura EAM, Habeeb MS, Aldabaan NA, Ahmed YH, Zaafar D (2024) Piperazine ferulate impact on diabetes-induced testicular dysfunction: unveiling genetic insights, MAPK\/ERK\/JNK pathways, and TGF-\u03b2 signaling. Naunyn Schmiedebergs Arch Pharmacol 398(6):6719\u20136737. https:\/\/doi.org\/10.1007\/s00210-024-03654-y","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"4822_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.111325","volume":"127","author":"BA Abdel-Wahab","year":"2024","unstructured":"Abdel-Wahab BA, El-Shoura EAM, Habeeb MS, Zaafar D (2024) Dapagliflozin alleviates arsenic trioxide-induced hepatic injury in rats via modulating PI3K\/AkT\/mTOR, STAT3\/SOCS3\/p53\/MDM2 signaling pathways and miRNA-21, miRNA-122 expression. Int Immunopharmacol 127:111325. https:\/\/doi.org\/10.1016\/j.intimp.2023.111325","journal-title":"Int Immunopharmacol"},{"issue":"5","key":"4822_CR4","doi-asserted-by":"publisher","first-page":"3157","DOI":"10.1016\/j.sjbs.2022.01.052","volume":"29","author":"DM Aboraya","year":"2022","unstructured":"Aboraya DM, El Baz A, Risha EF, Abdelhamid FM (2022) Hesperidin ameliorates cisplatin induced hepatotoxicity and attenuates oxidative damage, cell apoptosis, and inflammation in rats. Saudi J Biol Sci 29(5):3157\u20133166. https:\/\/doi.org\/10.1016\/j.sjbs.2022.01.052","journal-title":"Saudi J Biol Sci"},{"key":"4822_CR5","doi-asserted-by":"publisher","unstructured":"Aebi H (1984) [13] Catalase in vitro, vol 105. In: Methods in enzymology. Academic Press, pp 121\u2013126. https:\/\/doi.org\/10.1016\/S0076-6879(84)05016-3","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"4822_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2025.106995","volume":"178","author":"I Aktas","year":"2025","unstructured":"Aktas I, Gur FM, Bilgi\u00e7 S (2025) Protection of lutein against the toxic effect of cisplatin on liver in male rat. Prostaglandins Other Lipid Mediat 178:106995. https:\/\/doi.org\/10.1016\/j.prostaglandins.2025.106995","journal-title":"Prostaglandins Other Lipid Mediat"},{"issue":"8","key":"4822_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/biom9080346","volume":"9","author":"SH Aladaileh","year":"2019","unstructured":"Aladaileh SH, Abukhalil MH, Saghir SAM, Hanieh H, Alfwuaires MA, Almaiman AA, Bin-Jumah M, Mahmoud AM (2019) Galangin activates Nrf2 signaling and attenuates oxidative damage, inflammation, and apoptosis in a rat model of cyclophosphamide-induced hepatotoxicity. Biomolecules 9(8):8. https:\/\/doi.org\/10.3390\/biom9080346","journal-title":"Biomolecules"},{"key":"4822_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1592511","volume":"16","author":"AH Alhowail","year":"2025","unstructured":"Alhowail AH (2025) Cisplatin induces hippocampal neurotoxicity and cognitive impairment in rats through neuroinflammation, oxidative stress, and overexpression of glutamatergic receptors mRNA. Front Pharmacol 16:1592511. https:\/\/doi.org\/10.3389\/fphar.2025.1592511","journal-title":"Front Pharmacol"},{"issue":"1","key":"4822_CR9","doi-asserted-by":"publisher","first-page":"9566","DOI":"10.1038\/s41598-025-93120-3","volume":"15","author":"MAM Ali","year":"2025","unstructured":"Ali MAM, Matouk AI, Hamza AA, Amin A, Heeba GH (2025) Gallic and glycyrrhetinic acids prevent azithromycin-induced liver damage in rats by mitigating oxidative stress and inflammation. Sci Rep 15(1):9566. https:\/\/doi.org\/10.1038\/s41598-025-93120-3","journal-title":"Sci Rep"},{"issue":"6","key":"4822_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/life15060934","volume":"15","author":"LA Almutairi","year":"2025","unstructured":"Almutairi LA, Abdelghaffar EG, Hafney HA, Ebaid HM, Alkhodair SA, Shaalan AAM, EL-Hak HNG (2025) Protective impacts of Chlorella vulgaris on cisplatin-induced toxicity in liver, kidney, and spleen of rats: role of oxidative stress, inflammation, and Nrf2 modulation. Life 15(6):6. https:\/\/doi.org\/10.3390\/life15060934","journal-title":"Life"},{"issue":"6","key":"4822_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/ph17060681","volume":"17","author":"HH Arab","year":"2024","unstructured":"Arab HH, Eid AH, Alsufyani SE, Ashour AM, Alnefaie AM, Alsharif NM, Alshehri AM, Almalawi AA, Alsowat AA, Abd El Aal HA, Hassan ESG, Elesawy WH, Elhemiely AA (2024) Activation of AMPK\/mTOR-driven autophagy and suppression of the HMGB1\/TLR4 pathway with pentoxifylline attenuates doxorubicin-induced hepatic injury in rats. Pharmaceuticals 17(6):681. https:\/\/doi.org\/10.3390\/ph17060681","journal-title":"Pharmaceuticals"},{"issue":"12","key":"4822_CR12","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1177\/09603271211026722","volume":"40","author":"R Bademci","year":"2021","unstructured":"Bademci R, Erdo\u011fan MA, Ero\u011flu E, Meral A, Erdo\u011fan A, Atasoy \u00d6, Erba\u015f O (2021) Demonstration of the protective effect of ghrelin in the livers of rats with cisplatin toxicity. Hum Exp Toxicol 40(12):2178\u20132187. https:\/\/doi.org\/10.1177\/09603271211026722","journal-title":"Hum Exp Toxicol"},{"key":"4822_CR13","unstructured":"Bancroft JD, Gamble M (2008) Theory and practice of histological techniques, 6th edn. Churchill Livingstone, Elsevier Health Sciences"},{"issue":"1-2","key":"4822_CR14","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1006\/abio.1976.9999","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72(1\u20132):248\u2013254. https:\/\/doi.org\/10.1006\/abio.1976.9999","journal-title":"Anal Biochem"},{"key":"4822_CR15","doi-asserted-by":"publisher","first-page":"102913","DOI":"10.1016\/j.tice.2025.102913","volume":"96","author":"F Da","year":"2025","unstructured":"Da F, Meng Y, Chen Y, Yuan Z, Liu Y, Dai Z (2025) Tetracera asiatica flavonoids attenuate alcohol-induced liver injury by suppressing oxidative stress and inflammation mediated by the Keap-1\/Nrf2\/HO-1, NF-\u03baB\/MAPK and PERK\/Nrf2 signaling pathways in alcoholic liver injury rats. Tissue Cell 96:102913. https:\/\/doi.org\/10.1016\/j.tice.2025.102913","journal-title":"Tissue Cell"},{"key":"4822_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2025.117433","volume":"502","author":"SF Darwish","year":"2025","unstructured":"Darwish SF, Abdel Mageed SS, Mahmoud AMA, El-Demerdash AA, Doghish AS, Azzam RK, Mohamed RE, Farouk EA, Noshy M, Shakweer MM, Elazazy O (2025) Pinocembrin protects against cisplatin-induced liver injury via modulation of oxidative stress, TAK-1 inflammation, and apoptosis. Toxicol Appl Pharmacol 502:117433. https:\/\/doi.org\/10.1016\/j.taap.2025.117433","journal-title":"Toxicol Appl Pharmacol"},{"issue":"3","key":"4822_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25030599","volume":"25","author":"Y Dong","year":"2020","unstructured":"Dong Y, Xing Y, Sun J, Sun W, Xu Y, Quan C (2020) Baicalein alleviates liver oxidative stress and apoptosis induced by high-level glucose through the activation of the PERK\/Nrf2 signaling pathway. Molecules 25(3):599. https:\/\/doi.org\/10.3390\/molecules25030599","journal-title":"Molecules"},{"issue":"11","key":"4822_CR18","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1007\/s00228-025-03894-8","volume":"81","author":"T Elemary","year":"2025","unstructured":"Elemary T, Abdelrahim MEA, Nicola M, Zaafar D (2025) Therapeutic impact of vildagliptin vs. gliclazide on insulin resistance and advanced glycated end product levels in newly diagnosed Egyptian diabetics: a randomized controlled trial. Eur J Clin Pharmacol 81(11):1593\u20131608. https:\/\/doi.org\/10.1007\/s00228-025-03894-8","journal-title":"Eur J Clin Pharmacol"},{"issue":"9","key":"4822_CR19","doi-asserted-by":"publisher","first-page":"e70465","DOI":"10.1002\/jbt.70465","volume":"39","author":"AA Elhemiely","year":"2025","unstructured":"Elhemiely AA, El-Fayoumi SH, Gadelmawla MHA, Mahran NA, Gad AM (2025) Hesperidin reduces hepatic injury induced by doxorubicin in rat model through its antioxidative and anti-inflammatory effects, focusing on SIRT-1\/NRF-2 pathways. J Biochem Mol Toxicol 39(9):e70465. https:\/\/doi.org\/10.1002\/jbt.70465","journal-title":"J Biochem Mol Toxicol"},{"issue":"25","key":"4822_CR20","doi-asserted-by":"publisher","first-page":"67771","DOI":"10.1007\/s11356-023-27021-1","volume":"30","author":"EAM El-Shoura","year":"2023","unstructured":"El-Shoura EAM, Salem MA, Ahmed YH, Ahmed LK, Zaafar D (2023) Combined \u03b2-sitosterol and trimetazidine mitigate potassium dichromate-induced cardiotoxicity in rats through the interplay between NF-\u03baB\/AMPK\/mTOR\/TLR4 and HO-1\/NADPH signaling pathways. Environ Sci Pollut Res Int 30(25):67771\u201367787. https:\/\/doi.org\/10.1007\/s11356-023-27021-1","journal-title":"Environ Sci Pollut Res Int"},{"key":"4822_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.111457","volume":"127","author":"MI Fahmy","year":"2024","unstructured":"Fahmy MI, Khalaf SS, Yassen NN, Sayed RH (2024) Nicorandil attenuates cisplatin-induced acute kidney injury in rats via activation of PI3K\/AKT\/mTOR signaling cascade and inhibition of autophagy. Int Immunopharmacol 127:111457. https:\/\/doi.org\/10.1016\/j.intimp.2023.111457","journal-title":"Int Immunopharmacol"},{"key":"4822_CR22","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.freeradbiomed.2024.06.005","volume":"222","author":"HSS Gazwi","year":"2024","unstructured":"Gazwi HSS, Zaki AH, Abd Allah NAR, Gomaa AT, Milo\u0161evi\u0107 M, Al-Rejaie SS, Mohany M, Yassien EE (2024) Mitigation of cisplatin-induced hepatotoxicity by Salvia officinalis: attenuation of oxidative damage and inflammation in rats. Free Radic Biol Med 222:62\u201371. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2024.06.005","journal-title":"Free Radic Biol Med"},{"issue":"5","key":"4822_CR23","doi-asserted-by":"publisher","first-page":"440","DOI":"10.4103\/1735-5362.236837","volume":"13","author":"M Hamzeh","year":"2018","unstructured":"Hamzeh M, Hosseinimehr SJ, Khalatbary AR, Mohammadi HR, Dashti A, Amiri FT (2018) Atorvastatin mitigates cyclophosphamide-induced hepatotoxicity via suppression of oxidative stress and apoptosis in rat model. Res Pharm Sci 13(5):440\u2013449. https:\/\/doi.org\/10.4103\/1735-5362.236837","journal-title":"Res Pharm Sci"},{"key":"4822_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2024.107795","volume":"246","author":"X He","year":"2024","unstructured":"He X, Peng X, Zhang S, Yang T, Huo J, Zhang Y (2024) Hepatoprotective effect of diammonium glycyrrhizinate and neuroprotective effect of piperazine ferulate on AmB-induced liver and kidney injury by suppressing apoptosis in vitro and in vivo. Toxicon 246:107795. https:\/\/doi.org\/10.1016\/j.toxicon.2024.107795","journal-title":"Toxicon"},{"issue":"3","key":"4822_CR25","doi-asserted-by":"publisher","first-page":"e13817","DOI":"10.1002\/jcsm.13817","volume":"16","author":"K Huang","year":"2025","unstructured":"Huang K, Chiang Y, Ali M, Hsia S (2025) Cisplatin-induced muscle wasting and atrophy: molecular mechanism and potential therapeutic interventions. J Cachexia Sarcopenia Muscle 16(3):e13817. https:\/\/doi.org\/10.1002\/jcsm.13817","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"4822_CR26","doi-asserted-by":"publisher","unstructured":"Ijaz MU, Furqan R, Salar MZ, Hamza A, Ashraf A, Hamdi H (2025) Pharmacotherapeutic potentials of astragalin against cisplatin-induced renal toxicity via regulating Nrf-2\/keap-1 pathway. Arch Physiol Biochem 0(0):1\u201313. https:\/\/doi.org\/10.1080\/13813455.2025.2508419","DOI":"10.1080\/13813455.2025.2508419"},{"issue":"5","key":"4822_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.70300","volume":"39","author":"GAM Kamel","year":"2025","unstructured":"Kamel GAM, Hussein S (2025) Vinpocetine mitigates methotrexate-induced liver injury in rats through modulating intercellular communication. J Biochem Mol Toxicol 39(5):e70300. https:\/\/doi.org\/10.1002\/jbt.70300","journal-title":"J Biochem Mol Toxicol"},{"issue":"3","key":"4822_CR28","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1007\/s12011-023-03742-9","volume":"202","author":"MN Kelada","year":"2024","unstructured":"Kelada MN, Elagawany A, El Sekily NM, El Mallah M, Abou Nazel MW (2024) Protective effect of platelet-rich plasma on cisplatin-induced nephrotoxicity in adult male albino rats: histological and immunohistochemical study. Biol Trace Elem Res 202(3):1067\u20131083. https:\/\/doi.org\/10.1007\/s12011-023-03742-9","journal-title":"Biol Trace Elem Res"},{"key":"4822_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.174856","volume":"920","author":"Z Lei","year":"2022","unstructured":"Lei Z, Luan F, Zhang X, Peng L, Li B, Peng X, Liu Y, Liu R, Zeng N (2022) Piperazine ferulate protects against cardiac ischemia\/reperfusion injury in rat via the suppression of NLRP3 inflammasome activation and pyroptosis. Eur J Pharmacol 920:174856. https:\/\/doi.org\/10.1016\/j.ejphar.2022.174856","journal-title":"Eur J Pharmacol"},{"key":"4822_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154021","volume":"99","author":"D Li","year":"2022","unstructured":"Li D, Li B, Rui Y, Xie H, Zhang X, Liu R, Zeng N (2022) Piperazine ferulate attenuates gentamicin-induced acute kidney injury via the NF-\u03baB\/NLRP3 pathway. Phytomedicine 99:154021. https:\/\/doi.org\/10.1016\/j.phymed.2022.154021","journal-title":"Phytomedicine"},{"key":"4822_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1557125","volume":"16","author":"J Li","year":"2025","unstructured":"Li J, Yang X, Lian X, Li B, Ma Q, Yang L, Gao G, Deng Y, Yang Z (2025) Licorice attenuates cisplatin-induced hepatotoxicity by alleviating endoplasmic reticulum stress and apoptosis. Frontiers in Pharmacology 16:1557125. https:\/\/doi.org\/10.3389\/fphar.2025.1557125","journal-title":"Frontiers in Pharmacology"},{"issue":"1","key":"4822_CR32","doi-asserted-by":"publisher","first-page":"169","DOI":"10.3892\/etm.2016.3312","volume":"12","author":"Z Liu","year":"2016","unstructured":"Liu Z, Pan J, Sun C, Zhou J, Li NA (2016) Clinical effects of perazine ferulate tablets combined with eucalyptol limonene pinene enteric soft capsules for treatment of children with IgA nephropathy. Exp Ther Med 12(1):169\u2013172. https:\/\/doi.org\/10.3892\/etm.2016.3312","journal-title":"Exp Ther Med"},{"issue":"1\u20132","key":"4822_CR33","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0027-5107(85)90216-7","volume":"148","author":"SL Marklund","year":"1985","unstructured":"Marklund SL (1985) Superoxide dismutase isoenzymes in tissues and plasma from New Zealand black mice, nude mice and normal BALB\/c mice. Mutat Res 148(1\u20132):129\u2013134. https:\/\/doi.org\/10.1016\/0027-5107(85)90216-7","journal-title":"Mutat Res"},{"issue":"1","key":"4822_CR34","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","volume":"86","author":"M Mihara","year":"1978","unstructured":"Mihara M, Uchiyama M (1978) Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 86(1):271\u2013278. https:\/\/doi.org\/10.1016\/0003-2697(78)90342-1","journal-title":"Anal Biochem"},{"issue":"8","key":"4822_CR35","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfaf212","volume":"18","author":"L Nardelli","year":"2025","unstructured":"Nardelli L, Mohan A, Herrmann SM (2025) Reinforcing the role of magnesium in preventing cisplatin-induced nephrotoxicity: real-world evidence and clinical implications. Clin Kidney J 18(8):sfaf212. https:\/\/doi.org\/10.1093\/ckj\/sfaf212","journal-title":"Clin Kidney J"},{"key":"4822_CR36","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.toxrep.2014.09.003","volume":"1","author":"AY Nasr","year":"2014","unstructured":"Nasr AY (2014) Protective effect of aged garlic extract against the oxidative stress induced by cisplatin on blood cells parameters and hepatic antioxidant enzymes in rats. Toxicol Rep 1:682\u2013691. https:\/\/doi.org\/10.1016\/j.toxrep.2014.09.003","journal-title":"Toxicol Rep"},{"issue":"1","key":"4822_CR37","first-page":"158","volume":"70","author":"DE Paglia","year":"1967","unstructured":"Paglia DE, Valentine WN (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70(1):158\u2013169","journal-title":"J Lab Clin Med"},{"issue":"1","key":"4822_CR38","doi-asserted-by":"publisher","first-page":"217580","DOI":"10.1155\/2012\/217580","volume":"2012","author":"H Pan","year":"2012","unstructured":"Pan H, Wang H, Wang X, Zhu L, Mao L (2012) The absence of Nrf2 enhances NF-\u03baB-dependent inflammation following scratch injury in mouse primary cultured astrocytes. Mediators Inflamm 2012(1):217580. https:\/\/doi.org\/10.1155\/2012\/217580","journal-title":"Mediators Inflamm"},{"key":"4822_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2025.102951","volume":"96","author":"RA Rasheed","year":"2025","unstructured":"Rasheed RA, Sadek AS, Khattab RT, Saad DZ, Shawky NO, Abdelfattah HA (2025) Could hesperetin ameliorate doxorubicin-induced nephrotoxicity in rats via its antioxidant, antiapoptotic, and anti-inflammatory properties? Tissue Cell 96:102951. https:\/\/doi.org\/10.1016\/j.tice.2025.102951","journal-title":"Tissue Cell"},{"issue":"1","key":"4822_CR40","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","volume":"25","author":"J Sedlak","year":"1968","unstructured":"Sedlak J, Lindsay RH (1968) Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman\u2019s reagent. Anal Biochem 25(1):192\u2013205. https:\/\/doi.org\/10.1016\/0003-2697(68)90092-4","journal-title":"Anal Biochem"},{"key":"4822_CR41","doi-asserted-by":"publisher","unstructured":"Sert NPdu, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Karp NA, Lazic SE, Lidster K, MacCallum CJ, Macleod M, W\u00fcrbel H (2020) The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PLoS Biol 18(7):e3000410. https:\/\/doi.org\/10.1371\/journal.pbio.3000410","DOI":"10.1371\/journal.pbio.3000410"},{"issue":"12","key":"4822_CR42","doi-asserted-by":"publisher","DOI":"10.3390\/toxics12120864","volume":"12","author":"J Tang","year":"2024","unstructured":"Tang J, Wang K, Shen D, Li C (2024) Oxidative stress and Keap1-Nrf2 pathway involvement in bisphenol A-induced liver damage in rats. Toxics 12(12):12. https:\/\/doi.org\/10.3390\/toxics12120864","journal-title":"Toxics"},{"issue":"4","key":"4822_CR43","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1042\/BST20150014","volume":"43","author":"JD Wardyn","year":"2015","unstructured":"Wardyn JD, Ponsford AH, Sanderson CM (2015) Dissecting molecular cross-talk between Nrf2 and NF-\u03baB response pathways. Biochem Soc Trans 43(4):621\u2013626. https:\/\/doi.org\/10.1042\/BST20150014","journal-title":"Biochem Soc Trans"},{"issue":"8","key":"4822_CR44","doi-asserted-by":"publisher","first-page":"3064","DOI":"10.1039\/D4FO06059H","volume":"16","author":"E Xu","year":"2025","unstructured":"Xu E, Yu Z, Zheng J (2025) Lycopene improves cisplatin induced hepatointestinal injury in rats by modulating the microbe\u2013gut\u2013liver axis. Food Funct 16(8):3064\u20133074. https:\/\/doi.org\/10.1039\/D4FO06059H","journal-title":"Food Funct"},{"issue":"3","key":"4822_CR45","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.3892\/mmr.2019.9875","volume":"19","author":"Y-Y Yang","year":"2019","unstructured":"Yang Y-Y, Shi L-X, Li J-H, Yao L-Y, Xiang D-X (2019) Piperazine ferulate ameliorates the development of diabetic nephropathy by regulating endothelial nitric oxide synthase. Mol Med Rep 19(3):2245\u20132253. https:\/\/doi.org\/10.3892\/mmr.2019.9875","journal-title":"Mol Med Rep"},{"key":"4822_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122714","volume":"349","author":"K Yang","year":"2024","unstructured":"Yang K, Yu X, Guo Z, Fang Z, Zhang H, Zhang W, Liu C, Ji Y, Dong Z, Gu Q, Yao J, Liu C (2024) PIM1 alleviated liver oxidative stress and NAFLD by regulating the NRF2\/HO-1\/NQO1 pathway. Life Sci 349:122714. https:\/\/doi.org\/10.1016\/j.lfs.2024.122714","journal-title":"Life Sci"},{"issue":"8","key":"4822_CR47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0271631","volume":"17","author":"D Zaafar","year":"2022","unstructured":"Zaafar D, Khalil HMA, Rasheed RA, Eltelbany RFA, Zaitone SA (2022) Hesperetin mitigates sorafenib-induced cardiotoxicity in mice through inhibition of the TLR4\/NLRP3 signaling pathway. PLoS ONE 17(8):e0271631. https:\/\/doi.org\/10.1371\/journal.pone.0271631","journal-title":"PLoS ONE"},{"key":"4822_CR48","doi-asserted-by":"publisher","unstructured":"Zaafar D, Khalil HMA, Elnaggar R, Saad DZ, Rasheed RA (2023) Protective role of hesperetin in sorafenib-induced hepato- and neurotoxicity in mice via modulating apoptotic pathways and mitochondrial reprogramming. Life Sci 122295. https:\/\/doi.org\/10.1016\/j.lfs.2023.122295","DOI":"10.1016\/j.lfs.2023.122295"},{"key":"4822_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122295","volume":"336","author":"D Zaafar","year":"2024","unstructured":"Zaafar D, Khalil HMA, Elnaggar R, Saad DZ, Rasheed RA (2024) Protective role of hesperetin in sorafenib-induced hepato- and neurotoxicity in mice via modulating apoptotic pathways and mitochondrial reprogramming. Life Sci 336:122295. https:\/\/doi.org\/10.1016\/j.lfs.2023.122295","journal-title":"Life Sci"},{"issue":"8","key":"4822_CR50","doi-asserted-by":"publisher","first-page":"5715","DOI":"10.1007\/s00210-024-02976-1","volume":"397","author":"X-M Zhang","year":"2024","unstructured":"Zhang X-M, Min X-R, Li D, Li B, Rui Y-X, Xie H-X, Liu R, Zeng N (2024a) The protective effect and mechanism of piperazine ferulate in rats with 5\/6 nephrectomy-caused chronic kidney disease. Naunyn-Schmiedebergs Arch Pharmacol 397(8):5715\u20135729. https:\/\/doi.org\/10.1007\/s00210-024-02976-1","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"4822_CR51","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1394369","volume":"15","author":"X-M Zhang","year":"2024","unstructured":"Zhang X-M, Min X-R, Xie H-X, Jiang Y-N, Rui Y-X, Li B, Zeng N, Liu R (2024b) Piperazine ferulate inhibits diabetic nephropathy by suppressing AGE\/RAGE-mediated inflammatory signaling in rats and podocytes. Front Pharmacol 15:1394369. https:\/\/doi.org\/10.3389\/fphar.2024.1394369","journal-title":"Front Pharmacol"},{"issue":"1","key":"4822_CR52","doi-asserted-by":"publisher","first-page":"6604","DOI":"10.1038\/s41598-025-91133-6","volume":"15","author":"AM Zobeydi","year":"2025","unstructured":"Zobeydi AM, Mousavi Namavar SN, Sadeghi Shahdani M, Choobineh S, Kordi MR, Rakhshan K (2025) Mitigating doxorubicin-induced hepatotoxicity in male rats: the role of aerobic interval training and curcumin supplementation in reducing oxidative stress, endoplasmic reticulum stress and apoptosis. Sci Rep 15(1):6604. https:\/\/doi.org\/10.1038\/s41598-025-91133-6","journal-title":"Sci Rep"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04822-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04822-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04822-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T06:51:23Z","timestamp":1775458283000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04822-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,8]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["4822"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04822-4","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,8]]},"assertion":[{"value":"8 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study procedures were approved and held with ethical compliance and under the NIH Guides and Ethics Committee for Animal Experiments at the Faculty of Medicine, Al-Azhar University (registration number: Pha._5Med.Research_Cisplatin\/Piperazine Ferulate 0000024).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}]}}