{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T18:30:55Z","timestamp":1788633055853,"version":"build-2803163510"},"reference-count":91,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s00210-025-04827-z","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T09:53:08Z","timestamp":1764669188000},"page":"7053-7073","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Network pharmacology and molecular simulation insights into the anti-diabetic and anti-inflammatory mechanisms of Ricinus communis"],"prefix":"10.1007","volume":"399","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5296-0650","authenticated-orcid":false,"given":"Bidhayak","family":"Chakraborty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7339-5715","authenticated-orcid":false,"given":"Sreenivasa","family":"Nayaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6430-2896","authenticated-orcid":false,"given":"Chandan A.","family":"Bhairappanavar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6744-4405","authenticated-orcid":false,"given":"Gireesh Babu","family":"Kantli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4920-6459","authenticated-orcid":false,"given":"Shashiraj Kariyellappa","family":"Nagaraja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"4827_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00749","volume":"8","author":"TD Ahrens","year":"2020","unstructured":"Ahrens TD, Bang CSR, J\u00f8rgensen AM et al (2020) The role of proteoglycans in cancer metastasis and circulating tumor cell analysis. Front Cell Dev Biol 8:749. https:\/\/doi.org\/10.3389\/fcell.2020.00749","journal-title":"Front Cell Dev Biol"},{"issue":"6","key":"4827_CR2","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1016\/j.jsps.2023.04.003","volume":"31","author":"MA Alamri","year":"2023","unstructured":"Alamri MA (2023) Bioinformatics and network pharmacology-based study to elucidate the multi-target pharmacological mechanism of the indigenous plants of Medina valley in treating HCV-related hepatocellular carcinoma. Saudi Pharm J 31(6):1125\u20131138. https:\/\/doi.org\/10.1016\/j.jsps.2023.04.003","journal-title":"Saudi Pharm J"},{"key":"4827_CR3","doi-asserted-by":"publisher","first-page":"22027","DOI":"10.1038\/s41598-024-72577-8","volume":"14","author":"MY Alsedfy","year":"2024","unstructured":"Alsedfy MY, Ebnalwaled AA, Moustafa M et al (2024) Investigating the binding affinity, molecular dynamics, and ADMET properties of curcumin-IONPs as a mucoadhesive bioavailable oral treatment for iron deficiency anemia. Sci Rep 14:22027. https:\/\/doi.org\/10.1038\/s41598-024-72577-8","journal-title":"Sci Rep"},{"issue":"2","key":"4827_CR4","first-page":"10","volume":"4","author":"K Anil","year":"2023","unstructured":"Anil K, Krishanu S (2023) A review on phytochemical and pharmacological activity of Ricinus communis [castor] plant. Int J Multidiscip Res Growth Eval 4(2):10\u201315","journal-title":"Int J Multidiscip Res Growth Eval"},{"issue":"9","key":"4827_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e29871","volume":"10","author":"R Aryan","year":"2024","unstructured":"Aryan R, Parham R, Amirreza N et al (2024) NF-\u0138B axis in diabetic neuropathy, cardiomyopathy and nephropathy: a roadmap from molecular intervention to therapeutic strategies. Heliyon 10(9):e29871. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e29871","journal-title":"Heliyon"},{"issue":"5","key":"4827_CR6","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20202191","volume":"218","author":"R Bechara","year":"2021","unstructured":"Bechara R, McGeachy MJ, Gaffen SL (2021) The metabolism-modulating activity of IL-17 signaling in health and disease. J Exp Med 218(5):e20202191. https:\/\/doi.org\/10.1084\/jem.20202191","journal-title":"J Exp Med"},{"key":"4827_CR7","first-page":"34","volume":"3","author":"N Benariba","year":"2023","unstructured":"Benariba N, Fekhikher Z, Brixi-Gormat R et al (2023) In vitro antioxidant and antidiabetic activities of the hydro-acetone extracts of Ricinus communis and Teucrium polium from Tlemcen area. J Nat Prod Res Appl 3:34\u201346","journal-title":"J Nat Prod Res Appl"},{"issue":"1","key":"4827_CR8","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1128\/MMBR.00031-10","volume":"75","author":"M Cargnello","year":"2011","unstructured":"Cargnello M, Roux PP (2011) Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev 75(1):50\u201383. https:\/\/doi.org\/10.1128\/MMBR.00031-10","journal-title":"Microbiol Mol Biol Rev"},{"issue":"1","key":"4827_CR9","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.autrev.2009.02.031","volume":"9","author":"P Cejkova","year":"2009","unstructured":"Cejkova P, Fojtikova M, Cerna M (2009) Immunomodulatory role of prolactin in diabetes development. Autoimmun Rev 9(1):23\u201327. https:\/\/doi.org\/10.1016\/j.autrev.2009.02.031","journal-title":"Autoimmun Rev"},{"issue":"6","key":"4827_CR10","doi-asserted-by":"publisher","first-page":"7204","DOI":"10.18632\/oncotarget.23208","volume":"9","author":"L Chen","year":"2017","unstructured":"Chen L, Deng H, Cui H et al (2017) Inflammatory responses and inflammation-associated diseases in organs. Oncotarget 9(6):7204\u20137218. https:\/\/doi.org\/10.18632\/oncotarget.23208","journal-title":"Oncotarget"},{"key":"4827_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114578","volume":"162","author":"HL Chen","year":"2023","unstructured":"Chen HL, Jamie LMO, Eng SO et al (2023) Relaxin elicits renoprotective actions accompanied by increasing bile acid levels in streptozotocin-induced diabetic mice. Biomed Pharmacother 162:114578. https:\/\/doi.org\/10.1016\/j.biopha.2023.114578","journal-title":"Biomed Pharmacother"},{"issue":"11","key":"4827_CR12","doi-asserted-by":"publisher","first-page":"599","DOI":"10.5483\/bmbrep.2014.47.11.174","volume":"47","author":"SS Choi","year":"2014","unstructured":"Choi SS, Park J, Choi JH (2014) Revisiting PPAR\u03b3 as a target for the treatment of metabolic disorders. BMB Rep 47(11):599\u2013608. https:\/\/doi.org\/10.5483\/bmbrep.2014.47.11.174","journal-title":"BMB Rep"},{"key":"4827_CR13","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.3389\/fimmu.2020.01582","volume":"11","author":"G Daryabor","year":"2020","unstructured":"Daryabor G, Atashzar MR, Kabelitz D et al (2020) The effects of type 2 diabetes mellitus on organ metabolism and the immune system. Front Immunol 11:1582. https:\/\/doi.org\/10.3389\/fimmu.2020.01582","journal-title":"Front Immunol"},{"key":"4827_CR14","doi-asserted-by":"publisher","first-page":"773","DOI":"10.2337\/db09-9028","volume":"58","author":"RA Defronzo","year":"2009","unstructured":"Defronzo RA (2009) From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes 58:773\u2013795. https:\/\/doi.org\/10.2337\/db09-9028","journal-title":"Diabetes"},{"issue":"4","key":"4827_CR15","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1177\/039463200902200409","volume":"22","author":"R Di Paola","year":"2009","unstructured":"Di Paola R, Crisafulli C, Mazzon E et al (2009) Effect of PD98059, a selective MAPK3\/MAPK1 inhibitor, on acute lung injury in mice. Int J Immunopathol Pharmacol 22(4):937\u2013950. https:\/\/doi.org\/10.1177\/039463200902200409","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"3","key":"4827_CR16","doi-asserted-by":"publisher","first-page":"130","DOI":"10.4239\/wjd.v14.i3.130","volume":"14","author":"PV Dludla","year":"2023","unstructured":"Dludla PV, Mabhida SE, Ziqubu K et al (2023) Pancreatic \u03b2-cell dysfunction in type 2 diabetes: implications of inflammation and oxidative stress. World J Diabetes 14(3):130\u2013146. https:\/\/doi.org\/10.4239\/wjd.v14.i3.130","journal-title":"World J Diabetes"},{"issue":"3","key":"4827_CR17","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.mce.2014.09.013","volume":"418","author":"J Frasor","year":"2015","unstructured":"Frasor J, El-Shennawy L, Stender JD, Kastrati I (2015) NF\u03baB affects estrogen receptor expression and activity in breast cancer through multiple mechanisms. Mol Cell Endocrinol 418(3):235\u2013239. https:\/\/doi.org\/10.1016\/j.mce.2014.09.013","journal-title":"Mol Cell Endocrinol"},{"key":"4827_CR18","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.3389\/fphys.2020.01035","volume":"11","author":"A Gabryelska","year":"2020","unstructured":"Gabryelska A, Karuga FF, Szmyd B, Bia\u0142asiewicz P (2020) HIF-1\u03b1 as a mediator of insulin resistance, T2DM, and its complications: potential links with obstructive sleep apnea. Front Physiol 11:1035. https:\/\/doi.org\/10.3389\/fphys.2020.01035","journal-title":"Front Physiol"},{"key":"4827_CR19","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.6441","volume":"7","author":"MAM Gad-Elkareem","year":"2019","unstructured":"Gad-Elkareem MAM, Abdelgadir EH, Badawy OM, Kadri A (2019) Potential antidiabetic effect of ethanolic and aqueous-ethanolic extracts of Ricinus communis leaves on streptozotocin-induced diabetes in rats. PeerJ 7:e6441. https:\/\/doi.org\/10.7717\/peerj.6441","journal-title":"PeerJ"},{"key":"4827_CR20","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.neubiorev.2017.07.017","volume":"84","author":"M Gerwyn","year":"2018","unstructured":"Gerwyn M, Ken W, Andr\u00e9 FC et al (2018) The role of hypernitrosylation in the pathogenesis and pathophysiology of neuroprogressive diseases. Neurosci Biobehav Rev 84:453\u2013469. https:\/\/doi.org\/10.1016\/j.neubiorev.2017.07.017","journal-title":"Neurosci Biobehav Rev"},{"key":"4827_CR21","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1007\/s10989-020-10157-w","volume":"27","author":"P Ghosh","year":"2021","unstructured":"Ghosh P, Bhakta S, Bhattacharya M et al (2021) A novel multi-epitopic peptide vaccine candidate against Helicobacter pylori: in-silico identification, design, cloning and validation through molecular dynamics. Int J Pept Res Ther 27:1149\u20131166","journal-title":"Int J Pept Res Ther"},{"issue":"5","key":"4827_CR22","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/nrm2391","volume":"9","author":"A Guilherme","year":"2008","unstructured":"Guilherme A, Virbasius JV, Puri V, Czech MP (2008) Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol 9(5):367\u2013377. https:\/\/doi.org\/10.1038\/nrm2391","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4827_CR23","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1080\/13102818.2019.1578691","volume":"33","author":"NM Hajrah","year":"2019","unstructured":"Hajrah NM, Abdul W, Al-Garni S et al (2019) Gene expression profiling to elucidate the pharmacological and toxicological effects of Ricinus communis L. leaf extract in mammalian cells. Biotechnol Biotechnol Equip 33:397\u2013407","journal-title":"Biotechnol Biotechnol Equip"},{"issue":"3","key":"4827_CR24","first-page":"727","volume":"10","author":"Y Han","year":"2020","unstructured":"Han Y, Liu D, Li L (2020) PD-1\/PD-L1 pathway: current researches in cancer. Am J Cancer Res 10(3):727\u2013742","journal-title":"Am J Cancer Res"},{"key":"4827_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.dmpk.2021.100392","volume":"38","author":"O Hisakazu","year":"2021","unstructured":"Hisakazu O, Risa I, Ayuko I, Takeshi A (2021) Estimation of absolute oral bioavailability without performing an intravenous clinical study. Drug Metab Pharmacokinet 38:100392. https:\/\/doi.org\/10.1016\/j.dmpk.2021.100392","journal-title":"Drug Metab Pharmacokinet"},{"key":"4827_CR26","doi-asserted-by":"publisher","unstructured":"Holbrook J, Lara RS, Jarosz GH, McDermott M (2019) Tumour necrosis factor signalling in health and disease. F1000Res 8(F1000 Faculty Rev):111. https:\/\/doi.org\/10.12688\/f1000research.17023.1","DOI":"10.12688\/f1000research.17023.1"},{"key":"4827_CR27","doi-asserted-by":"publisher","first-page":"9569","DOI":"10.1038\/s41598-023-36687-z","volume":"13","author":"M Hu","year":"2023","unstructured":"Hu M, Yan H, Li H et al (2023) Use of network pharmacology and molecular docking to explore the mechanism of action of curcuma in the treatment of osteosarcoma. Sci Rep 13:9569. https:\/\/doi.org\/10.1038\/s41598-023-36687-z","journal-title":"Sci Rep"},{"key":"4827_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01620-3","volume":"8","author":"L Huangfu","year":"2023","unstructured":"Huangfu L, Li R, Huang Y, Wang S (2023) The IL-17 family in diseases: from bench to bedside. Signal Transduct Target Ther 8:402. https:\/\/doi.org\/10.1038\/s41392-023-01620-3","journal-title":"Signal Transduct Target Ther"},{"issue":"17","key":"4827_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2022.167696","volume":"434","author":"D Igors","year":"2022","unstructured":"Igors D, Tom CBM (2022) Optimising elastic network models for protein dynamics and allostery: spatial and modal cut-offs and backbone stiffness. J Mol Biol 434(17):167696. https:\/\/doi.org\/10.1016\/j.jmb.2022.167696","journal-title":"J Mol Biol"},{"key":"4827_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.prmcm.2025.100630","volume":"15","author":"VC Issac","year":"2025","unstructured":"Issac VC, Abhishek V, Islam MM, Janvi, Akash V (2025) Assessing the therapeutic potential of quercetin, a widely spread flavonoid, in the prevention and management of chronic and degenerative diseases through a modern Chinese medicine perspective. Pharmacol Res Mod Chin Med 15:100630. https:\/\/doi.org\/10.1016\/j.prmcm.2025.100630","journal-title":"Pharmacol Res Mod Chin Med"},{"issue":"5","key":"4827_CR31","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.4049\/jimmunol.169.5.2643","volume":"169","author":"T Itoh","year":"2002","unstructured":"Itoh T, Matsuda H, Tanioka M, Kuwabara K, Itohara S, Suzuki R (2002) The role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in antibody-induced arthritis. J Immunol 169(5):2643\u20132647. https:\/\/doi.org\/10.4049\/jimmunol.169.5.2643","journal-title":"J Immunol"},{"issue":"1","key":"4827_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15171\/jhp.2018.01","volume":"7","author":"KF Jamshidi","year":"2018","unstructured":"Jamshidi KF, Lorigooini Z, Amini-Khoei H (2018) Medicinal plants: past history and future perspective. J Herbmed Pharmacol 7(1):1\u20137. https:\/\/doi.org\/10.15171\/jhp.2018.01","journal-title":"J Herbmed Pharmacol"},{"key":"4827_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2025.107776","volume":"216","author":"C Jie","year":"2025","unstructured":"Jie C, Fei S, Chan LWC et al (2025) Inflammatory signalling pathways in pancreatic \u03b2-cell: new insights into type 2 diabetes pathogenesis. Pharmacol Res 216:107776. https:\/\/doi.org\/10.1016\/j.phrs.2025.107776","journal-title":"Pharmacol Res"},{"issue":"12","key":"4827_CR34","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.7150\/ijms.26774","volume":"15","author":"NBA Joan","year":"2018","unstructured":"Joan NBA, de F\u00e1tima LA, Campello RS et al (2018) Estrogen receptor 1 (ESR1) enhances Slc2a4\/GLUT4 expression by a SP1 cooperative mechanism. Int J Med Sci 15(12):1320\u20131328. https:\/\/doi.org\/10.7150\/ijms.26774","journal-title":"Int J Med Sci"},{"issue":"10","key":"4827_CR35","doi-asserted-by":"publisher","first-page":"3355","DOI":"10.2337\/db15-0242","volume":"64","author":"B Ke","year":"2015","unstructured":"Ke B, Zhao Z, Ye X et al (2015) Inactivation of NF-\u03baB p65 (RelA) in liver improves insulin sensitivity and inhibits cAMP\/PKA pathway. Diabetes 64(10):3355\u20133362. https:\/\/doi.org\/10.2337\/db15-0242","journal-title":"Diabetes"},{"issue":"4","key":"4827_CR36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062068","volume":"8","author":"JE Kim","year":"2013","unstructured":"Kim JE, Lee MH, Nam DH et al (2013) Celastrol, an NF-\u03baB inhibitor, improves insulin resistance and attenuates renal injury in db\/db mice. PLoS One 8(4):e62068. https:\/\/doi.org\/10.1371\/journal.pone.0062068","journal-title":"PLoS One"},{"key":"4827_CR38","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1186\/s12964-024-01791-8","volume":"22","author":"O Kosz\u0142a","year":"2024","unstructured":"Kosz\u0142a O, So\u0142ek P (2024) Misfolding and aggregation in neurodegenerative diseases: protein quality control machinery as potential therapeutic clearance pathways. Cell Commun Signal 22:421. https:\/\/doi.org\/10.1186\/s12964-024-01791-8","journal-title":"Cell Commun Signal"},{"issue":"6","key":"4827_CR39","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1517\/13543784.2012.681043","volume":"21","author":"RA Kowluru","year":"2012","unstructured":"Kowluru RA, Zhong Q, Santos JM (2012) Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9. Expert Opin Investig Drugs 21(6):797\u2013805. https:\/\/doi.org\/10.1517\/13543784.2012.681043","journal-title":"Expert Opin Investig Drugs"},{"issue":"5","key":"4827_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/ph18050648","volume":"18","author":"S Kurmi","year":"2025","unstructured":"Kurmi S, Majhi R, Tayara H, Chong KT (2025) Exploring ginseng bioactive compound\u2019s role in hypertension remedy: an in silico approach. Pharmaceuticals (Basel) 18(5):648. https:\/\/doi.org\/10.3390\/ph18050648","journal-title":"Pharmaceuticals (Basel)"},{"key":"4827_CR41","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1038\/oby.2008.267","volume":"16","author":"YH Lee","year":"2008","unstructured":"Lee YH, William GT, Rhonda LM et al (2008) Amyloid precursor protein expression is upregulated in adipocytes in obesity. Obesity 16:1493\u20131500. https:\/\/doi.org\/10.1038\/oby.2008.267","journal-title":"Obesity"},{"key":"4827_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.891762","volume":"13","author":"H Lee","year":"2022","unstructured":"Lee H, Kim YI, Kim MJ et al (2022) Castor oil plant (Ricinus communis L.) leaves improve dexamethasone-induced muscle atrophy via Nrf2 activation. Front Pharmacol 13:891762","journal-title":"Front Pharmacol"},{"issue":"5","key":"4827_CR43","doi-asserted-by":"publisher","first-page":"5865","DOI":"10.3892\/ol.2017.6924","volume":"14","author":"H Li","year":"2017","unstructured":"Li H, Qiu Z, Li F, Wang C (2017) The relationship between MMP-2 and MMP-9 expression levels with breast cancer incidence and prognosis. Oncol Lett 14(5):5865\u20135870. https:\/\/doi.org\/10.3892\/ol.2017.6924","journal-title":"Oncol Lett"},{"key":"4827_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2024.156691","volume":"181","author":"H Liu","year":"2024","unstructured":"Liu H, Yuan S, Kai Z et al (2024) IL-17 signaling pathway: a potential therapeutic target for reducing skeletal muscle inflammation. Cytokine 181:156691. https:\/\/doi.org\/10.1016\/j.cyto.2024.156691","journal-title":"Cytokine"},{"key":"4827_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01951-9","volume":"9","author":"X Lu","year":"2024","unstructured":"Lu X, Xie Q, Pan X et al (2024) Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy. Signal Transduct Target Ther 9:262. https:\/\/doi.org\/10.1038\/s41392-024-01951-9","journal-title":"Signal Transduct Target Ther"},{"issue":"3","key":"4827_CR46","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.mehy.2013.05.020","volume":"81","author":"EF Marcos","year":"2013","unstructured":"Marcos EF (2013) Putative role of glycogen as a peripheral biomarker of GSK3\u03b2 activity. Med Hypotheses 81(3):376\u2013378. https:\/\/doi.org\/10.1016\/j.mehy.2013.05.020","journal-title":"Med Hypotheses"},{"key":"4827_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3897\/pharmacia.72.e146759","volume":"72","author":"MS Maria","year":"2025","unstructured":"Maria MS, Yozlem K, Spiro K et al (2025) The role of the transcription factor NF-\u03baB in the pathogenesis of inflammation and carcinogenesis: modulation capabilities. Pharmacia 72:1\u201313. https:\/\/doi.org\/10.3897\/pharmacia.72.e146759","journal-title":"Pharmacia"},{"issue":"1","key":"4827_CR48","doi-asserted-by":"publisher","first-page":"47","DOI":"10.52711\/2321-5836.2025.00008","volume":"17","author":"KV Megharaj","year":"2025","unstructured":"Megharaj KV, Veera ST, Pavithra MR, Mohammed SM (2025) A systematic review on phytochemical constituents and pharmacological activities of Ricinus communis plant. Res J Pharmacol Pharmacodynamics 17(1):47\u201351. https:\/\/doi.org\/10.52711\/2321-5836.2025.00008","journal-title":"Res J Pharmacol Pharmacodynamics"},{"issue":"5","key":"4827_CR49","doi-asserted-by":"publisher","DOI":"10.33263\/BRIAC145.115","volume":"14","author":"R Miah","year":"2024","unstructured":"Miah R, Mohd FFM, Normaiza BZ (2024) An in-silico approach to evaluate bioactive molecules of Aloe vera leaf extracts in inhibiting the glycogen synthase kinase-3\u03b2 (GSK3-\u03b2) protein for faster diabetic wound healing potential. Biointerface Res Appl Chem 14(5):115. https:\/\/doi.org\/10.33263\/BRIAC145.115","journal-title":"Biointerface Res Appl Chem"},{"issue":"6","key":"4827_CR50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26062770","volume":"26","author":"MM Mir","year":"2025","unstructured":"Mir MM, Jeelani M, Alharthi MH, Rizvi SF, Sohail SK, Wani JI, Sabah ZU, BinAfif WF, Nandi P, Alshahrani AM, Alfaifi J, Jehangir A, Mir R (2025) Unravelling the mystery of insulin resistance: from principle mechanistic insights and consequences to therapeutic interventions. Int J Mol Sci 26(6):2770. https:\/\/doi.org\/10.3390\/ijms26062770","journal-title":"Int J Mol Sci"},{"issue":"3","key":"4827_CR51","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26031094","volume":"26","author":"E M\u0142ynarska","year":"2025","unstructured":"M\u0142ynarska E, Czarnik W, Dzie\u017ca N, J\u0119draszak W, Majchrowicz G, Prusinowski F, Stabrawa M, Rysz J, Franczyk B (2025) Type 2 diabetes mellitus: new pathogenetic mechanisms, treatment and the most important complications. Int J Mol Sci 26(3):1094. https:\/\/doi.org\/10.3390\/ijms26031094","journal-title":"Int J Mol Sci"},{"issue":"13","key":"4827_CR52","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136922","volume":"22","author":"O Morrison","year":"2021","unstructured":"Morrison O, Thakur J (2021) Molecular complexes at euchromatin, heterochromatin and centromeric chromatin. Int J Mol Sci 22(13):6922. https:\/\/doi.org\/10.3390\/ijms22136922","journal-title":"Int J Mol Sci"},{"key":"4827_CR53","doi-asserted-by":"publisher","first-page":"1362456","DOI":"10.3389\/fddsv.2024.1362456","volume":"4","author":"U Naithani","year":"2024","unstructured":"Naithani U, Guleria V (2024) Integrative computational approaches for discovery and evaluation of lead compound for drug design. Front Drug Discov 4:1362456. https:\/\/doi.org\/10.3389\/fddsv.2024.1362456","journal-title":"Front Drug Discov"},{"issue":"4","key":"4827_CR54","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a000034","volume":"1","author":"A Oeckinghaus","year":"2009","unstructured":"Oeckinghaus A, Ghosh S (2009) The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol 1(4):a000034. https:\/\/doi.org\/10.1101\/cshperspect.a000034","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"4827_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.obmed.2025.100613","volume":"55","author":"OS Oladipupo","year":"2025","unstructured":"Oladipupo OS, Ezenabor EH, Ojo AB et al (2025) Interplay of the pathophysiological mechanisms of non-alcoholic fatty liver disease, diabetes mellitus, and inflammation: a growing threat to public health. Obes Med 55:100613. https:\/\/doi.org\/10.1016\/j.obmed.2025.100613","journal-title":"Obes Med"},{"issue":"18","key":"4827_CR56","doi-asserted-by":"publisher","DOI":"10.3390\/plants14182828","volume":"14","author":"CJ Ononamadu","year":"2025","unstructured":"Ononamadu CJ, Ahmed ZB, Seidel V (2025) Network pharmacology, molecular docking and molecular dynamics studies to predict the molecular targets and mechanisms of action of Melissa officinalis phytoconstituents in type-2 diabetes mellitus. Plants 14(18):2828. https:\/\/doi.org\/10.3390\/plants14182828","journal-title":"Plants"},{"key":"4827_CR57","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.907757","volume":"13","author":"ML Peng","year":"2022","unstructured":"Peng ML, Fu Y, Wu CW, Zhang Y, Ren H, Zhou S-S (2022) Signaling pathways related to oxidative stress in diabetic cardiomyopathy. Front Endocrinol (Lausanne) 13:907757. https:\/\/doi.org\/10.3389\/fendo.2022.907757","journal-title":"Front Endocrinol (Lausanne)"},{"key":"4827_CR58","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.fsi.2016.10.031","volume":"59","author":"NCN Perera","year":"2016","unstructured":"Perera NCN, Godahewa GI, Jehee L (2016) Mitogen-activated protein kinase 1 from disk abalone (Haliotis discus): roles in early development and immunity-related transcriptional responses. Fish Shellfish Immunol 59:57\u201365. https:\/\/doi.org\/10.1016\/j.fsi.2016.10.031","journal-title":"Fish Shellfish Immunol"},{"issue":"1","key":"4827_CR59","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3390\/pharmaceutics13010064","volume":"13","author":"D Placha","year":"2021","unstructured":"Placha D, Jampilek J (2021) Chronic inflammatory diseases, anti-inflammatory agents and their delivery nanosystems. Pharmaceutics 13(1):64. https:\/\/doi.org\/10.3390\/pharmaceutics13010064","journal-title":"Pharmaceutics"},{"issue":"10","key":"4827_CR60","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16101320","volume":"16","author":"E P\u00f6sty\u00e9ni","year":"2024","unstructured":"P\u00f6sty\u00e9ni E, G\u00e1briel R, Kov\u00e1cs VA (2024) Poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors in diabetic retinopathy: an attractive but elusive choice for drug development. Pharmaceutics 16(10):1320. https:\/\/doi.org\/10.3390\/pharmaceutics16101320","journal-title":"Pharmaceutics"},{"key":"4827_CR61","doi-asserted-by":"publisher","unstructured":"Prakash SSR, Kamalnath SM, Antonisamy AJ, et al (2023) In silico molecular docking of phytochemicals for type 2 diabetes mellitus therapy: a network pharmacology approach. Int J Mol Cell Med 12(4):372\u2013387. https:\/\/doi.org\/10.22088\/IJMCM.BUMS.12.4.372","DOI":"10.22088\/IJMCM.BUMS.12.4.372"},{"key":"4827_CR62","doi-asserted-by":"publisher","DOI":"10.1016\/j.crtox.2023.100118","volume":"5","author":"M Rai","year":"2023","unstructured":"Rai M, Singh AV, Paudel N et al (2023) Herbal concoction unveiled: a computational analysis of phytochemicals\u2019 pharmacokinetic and toxicological profiles using novel approach methodologies (NAMs). Curr Res Toxicol 5:100118. https:\/\/doi.org\/10.1016\/j.crtox.2023.100118","journal-title":"Curr Res Toxicol"},{"issue":"15","key":"4827_CR63","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30153214","volume":"30","author":"TP Ramothloa","year":"2025","unstructured":"Ramothloa TP, Mkolo NM, Motshudi MC et al (2025) Phytochemical composition and multifunctional applications of Ricinus communis L.: insights into therapeutic, pharmacological, and industrial potential. Molecules 30(15):3214. https:\/\/doi.org\/10.3390\/molecules30153214","journal-title":"Molecules"},{"key":"4827_CR64","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-9-23","volume":"9","author":"CV Ricarda","year":"2012","unstructured":"Ricarda CV, Alejandro BP, Juan JVA et al (2012) Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens. J Inflamm 9:23. https:\/\/doi.org\/10.1186\/1476-9255-9-23","journal-title":"J Inflamm"},{"issue":"3","key":"4827_CR65","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1002\/bmb.20937","volume":"44","author":"U Roy","year":"2016","unstructured":"Roy U (2016) Structural biology of tumor necrosis factor demonstrated for undergraduates instruction by computer simulation. Biochem Mol Biol Educ 44(3):246\u2013255. https:\/\/doi.org\/10.1002\/bmb.20937","journal-title":"Biochem Mol Biol Educ"},{"issue":"9","key":"4827_CR66","doi-asserted-by":"publisher","first-page":"4800","DOI":"10.1080\/07391102.2023.2222837","volume":"42","author":"M Saleem","year":"2023","unstructured":"Saleem M, Mazhar FM, Salman ASM, Shityakov S (2023) Network pharmacology and multi target analysis of Nigella sativa in the management of diabetes and obesity: a computational study. J Biomol Struct Dyn 42(9):4800\u20134816. https:\/\/doi.org\/10.1080\/07391102.2023.2222837","journal-title":"J Biomol Struct Dyn"},{"key":"4827_CR67","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.ejphar.2010.07.001","volume":"644","author":"AC Saragusti","year":"2010","unstructured":"Saragusti AC, Ortega MG, Cabrera JL et al (2010) Inhibitory effect of quercetin on matrix metalloproteinase 9 activity: molecular mechanism and structure-activity relationship of the flavonoid-enzyme interaction. Eur J Pharmacol 644:138\u2013145","journal-title":"Eur J Pharmacol"},{"key":"4827_CR68","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1016\/S0140-6736(10)60484-9","volume":"375","author":"N Sarwar","year":"2010","unstructured":"Sarwar N, Gao P, Seshasai SR et al (2010) Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet 375:2215\u20132222. https:\/\/doi.org\/10.1016\/S0140-6736(10)60484-9","journal-title":"Lancet"},{"issue":"6","key":"4827_CR69","doi-asserted-by":"publisher","first-page":"R559","DOI":"10.1152\/ajpregu.00528.2012","volume":"305","author":"JM Sasser","year":"2013","unstructured":"Sasser JM (2013) The emerging role of relaxin as a novel therapeutic pathway in the treatment of chronic kidney disease. Am J Physiol Regul Integr Comp Physiol 305(6):R559\u2013R565. https:\/\/doi.org\/10.1152\/ajpregu.00528.2012","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"6","key":"4827_CR70","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1016\/j.cmet.2025.03.014","volume":"37","author":"X Song","year":"2025","unstructured":"Song X, Zhou Z, Liu J et al (2025) Cytosolic cytochrome c represses ferroptosis. Cell Metab 37(6):1326-1343.e10. https:\/\/doi.org\/10.1016\/j.cmet.2025.03.014","journal-title":"Cell Metab"},{"issue":"21","key":"4827_CR71","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27217198","volume":"27","author":"A Sumera","year":"2022","unstructured":"Sumera A, Anwer F, Waseem M et al (2022) Molecular docking and molecular dynamics studies reveal secretory proteins as novel targets of temozolomide in glioblastoma multiforme. Molecules 27(21):7198. https:\/\/doi.org\/10.3390\/molecules27217198","journal-title":"Molecules"},{"key":"4827_CR72","doi-asserted-by":"publisher","first-page":"1417502","DOI":"10.3389\/fcell.2024.1417502","volume":"12","author":"X Sun","year":"2024","unstructured":"Sun X, Cao S, Mao C et al (2024) Post-translational modifications of p65: state of the art. Front Cell Dev Biol 12:1417502. https:\/\/doi.org\/10.3389\/fcell.2024.1417502","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"4827_CR73","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13010098","volume":"13","author":"PF Surai","year":"2024","unstructured":"Surai PF, Surai A, Earle PK (2024) Silymarin and inflammation: food for thoughts. Antioxidants (Basel) 13(1):98. https:\/\/doi.org\/10.3390\/antiox13010098","journal-title":"Antioxidants (Basel)"},{"key":"4827_CR74","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/978-981-15-3532-1_2","volume":"1254","author":"S Tanaka","year":"2020","unstructured":"Tanaka S, Baba Y (2020) B cell receptor signaling. Adv Exp Med Biol 1254:23\u201336. https:\/\/doi.org\/10.1007\/978-981-15-3532-1_2","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"4827_CR75","doi-asserted-by":"publisher","first-page":"50","DOI":"10.15420\/ecr.2018.33.1","volume":"14","author":"S Tsalamandris","year":"2019","unstructured":"Tsalamandris S, Antonopoulos AS, Oikonomou E et al (2019) The role of inflammation in diabetes: current concepts and future perspectives. Eur Cardiol 14(1):50\u201359. https:\/\/doi.org\/10.15420\/ecr.2018.33.1","journal-title":"Eur Cardiol"},{"issue":"2","key":"4827_CR76","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.gene.2015.11.052","volume":"577","author":"RE Turnham","year":"2016","unstructured":"Turnham RE, Scott JD (2016) Protein kinase A catalytic subunit isoform PRKACA; history, function and physiology. Gene 577(2):101\u2013108. https:\/\/doi.org\/10.1016\/j.gene.2015.11.052","journal-title":"Gene"},{"issue":"17","key":"4827_CR77","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176275","volume":"21","author":"GG Unai","year":"2020","unstructured":"Unai GG, Benito VA, Jebari S et al (2020) Pathophysiology of type 2 diabetes mellitus. Int J Mol Sci 21(17):6275. https:\/\/doi.org\/10.3390\/ijms21176275","journal-title":"Int J Mol Sci"},{"issue":"4","key":"4827_CR78","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v16.i4.99936","volume":"16","author":"G Vasilev","year":"2025","unstructured":"Vasilev G, Kokudeva M, Siliogka E, Padilla N, Shumnalieva R, Della-Morte D, Ricordi C, Mihova A, Infante M, Velikova T (2025) T helper 17 cells and interleukin-17 immunity in type 1 diabetes: from pathophysiology to targeted immunotherapies. World J Diabetes 16(4):99936. https:\/\/doi.org\/10.4239\/wjd.v16.i4.99936","journal-title":"World J Diabetes"},{"issue":"1","key":"4827_CR79","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-51150-3","volume":"14","author":"X Wang","year":"2024","unstructured":"Wang X, Liu M, Li X et al (2024) Utilizing molecular docking and cell validation to explore the potential mechanisms of lupenone attenuating the inflammatory response via NF-\u03baB pathway. Sci Rep 14(1):625. https:\/\/doi.org\/10.1038\/s41598-024-51150-3","journal-title":"Sci Rep"},{"key":"4827_CR80","doi-asserted-by":"publisher","first-page":"7162","DOI":"10.1111\/febs.15701","volume":"288","author":"B Wesam","year":"2021","unstructured":"Wesam B, Ali MAM, Richard S (2021) Multifunctional intracellular matrix metalloproteinases: implications in disease. FEBS J 288:7162\u20137182. https:\/\/doi.org\/10.1111\/febs.15701","journal-title":"FEBS J"},{"issue":"24","key":"4827_CR81","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252413691","volume":"25","author":"M Wolosowicz","year":"2024","unstructured":"Wolosowicz M, Prokopiuk S, Kaminski TW (2024) The complex role of matrix metalloproteinase-2 (MMP-2) in health and disease. Int J Mol Sci 25(24):13691. https:\/\/doi.org\/10.3390\/ijms252413691","journal-title":"Int J Mol Sci"},{"issue":"8","key":"4827_CR82","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e19151","volume":"9","author":"R Xia","year":"2023","unstructured":"Xia R, Yan CX, Zhai RX et al (2023) Comprehensive survey of target prediction web servers for traditional Chinese medicine. Heliyon 9(8):e19151. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e19151","journal-title":"Heliyon"},{"key":"4827_CR83","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1017\/CBO9780511806087.008","volume-title":"Essential bioinformatics","author":"J Xiong","year":"2006","unstructured":"Xiong J (2006) Protein motifs and domain prediction. Essential bioinformatics. Cambridge University Press, pp 85\u201394. https:\/\/doi.org\/10.1017\/CBO9780511806087.008"},{"issue":"3","key":"4827_CR84","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1016\/j.ajpath.2010.12.004","volume":"178","author":"B Xueqing","year":"2011","unstructured":"Xueqing B, Nisha JG (2011) Signaling mechanism of poly (ADP-ribose) polymerase-1 (PARP-1) in inflammatory diseases. Am J Pathol 178(3):946\u2013955. https:\/\/doi.org\/10.1016\/j.ajpath.2010.12.004","journal-title":"Am J Pathol"},{"key":"4827_CR85","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117058","volume":"177","author":"JP Yadav","year":"2024","unstructured":"Yadav JP, Verma A, Pathak P, Dwivedi AR, Singh AK, Kumar P, Khalilullah H, Jaremko M, Emwas A-H, Patel DK (2024) Phytoconstituents as modulators of NF-\u03baB signalling: investigating therapeutic potential for diabetic wound healing. Biomed Pharmacother 177:117058. https:\/\/doi.org\/10.1016\/j.biopha.2024.117058","journal-title":"Biomed Pharmacother"},{"key":"4827_CR86","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202303341","volume":"9","author":"S Yakobi","year":"2024","unstructured":"Yakobi S, Zuma L, Pooe O (2024) Molecular docking and structure-activity relationship analysis of target compounds against glyceraldehyde-3-phosphate dehydrogenase in azithromycin-resistant Neisseria gonorrhoeae. ChemistrySelect 9:e202303341. https:\/\/doi.org\/10.1002\/slct.202303341","journal-title":"ChemistrySelect"},{"key":"4827_CR87","doi-asserted-by":"publisher","first-page":"1209703","DOI":"10.3389\/fnmol.2023.1209703","volume":"16","author":"H Yu","year":"2023","unstructured":"Yu H, Xiong M, Zhang Z (2023) The role of glycogen synthase kinase 3 beta in neurodegenerative diseases. Front Mol Neurosci 16:1209703. https:\/\/doi.org\/10.3389\/fnmol.2023.1209703","journal-title":"Front Mol Neurosci"},{"key":"4827_CR88","doi-asserted-by":"publisher","unstructured":"Yuyun Y, Fahmi MRS, Nabila EE, et al (2021) Molecular docking analysis of Ficus religiosa active compound with anti-inflammatory activity by targeting tumour necrosis factor alpha and vascular endothelial growth factor receptor in diabetic wound healing. Maced J Med Sci 9(A):1031\u20131036. https:\/\/doi.org\/10.3889\/oamjms.2021.7068","DOI":"10.3889\/oamjms.2021.7068"},{"issue":"12","key":"4827_CR89","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002429","volume":"7","author":"W Zhang","year":"2011","unstructured":"Zhang W, Thompson BJ, Hietakangas V, Cohen SM (2011) MAPK\/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila. PLoS Genet 7(12):e1002429. https:\/\/doi.org\/10.1371\/journal.pgen.1002429","journal-title":"PLoS Genet"},{"key":"4827_CR90","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s11658-021-00283-8","volume":"26","author":"M Zhao","year":"2021","unstructured":"Zhao M, Wang S, Zuo A et al (2021) HIF-1\u03b1\/JMJD1A signaling regulates inflammation and oxidative stress following hyperglycemia and hypoxia-induced vascular cell injury. Cell Mol Biol Lett 26:40. https:\/\/doi.org\/10.1186\/s11658-021-00283-8","journal-title":"Cell Mol Biol Lett"},{"issue":"2","key":"4827_CR91","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nrendo.2017.151","volume":"14","author":"Y Zheng","year":"2018","unstructured":"Zheng Y, Ley SH, Hu FB (2018) Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol 14(2):88\u201398","journal-title":"Nat Rev Endocrinol"},{"key":"4827_CR92","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107282","volume":"206","author":"M Zhou","year":"2024","unstructured":"Zhou M, Yuyan Z, Lin S, et al (2024) Activation and modulation of the AGEs-RAGE axis: implications for inflammatory pathologies and therapeutic interventions- a review. Pharmacol Res 206:107282. https:\/\/doi.org\/10.1016\/j.phrs.2024.107282","journal-title":"Pharmacol Res"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04827-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04827-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04827-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T19:01:50Z","timestamp":1775502110000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04827-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,2]]},"references-count":91,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["4827"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04827-z","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,2]]},"assertion":[{"value":"21 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}