{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T07:48:54Z","timestamp":1775461734312,"version":"3.50.1"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Natural Science Foundation of Shandong Province of China","award":["ZR2022QH185"],"award-info":[{"award-number":["ZR2022QH185"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s00210-025-04830-4","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T07:00:23Z","timestamp":1764918023000},"page":"7183-7214","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An integrated approach combining computational analyses and experimental validation deciphers the mechanism and active substance basis of Huazhuo Ningfu decoction in treating psoriasis"],"prefix":"10.1007","volume":"399","author":[{"given":"Zitong","family":"Guan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengxue","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenke","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shasha","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiazheng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Man","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"issue":"3","key":"4830_CR1","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.anndiagpath.2011.09.005","volume":"16","author":"AG Abdou","year":"2012","unstructured":"Abdou AG et al (2012) Up-regulation of Notch-1 in psoriasis: an immunohistochemical study. Ann Diagn Pathol 16(3):177\u2013184","journal-title":"Ann Diagn Pathol"},{"issue":"4","key":"4830_CR2","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1074\/mcp.M113.035568","volume":"13","author":"MM Ahmed","year":"2014","unstructured":"Ahmed MM et al (2014) Protein profiles associated with context fear conditioning and their modulation by memantine. Mol Cell Proteomics 13(4):919\u2013937","journal-title":"Mol Cell Proteomics"},{"key":"4830_CR3","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29472-w","author":"R Ahn","year":"2018","unstructured":"Ahn R et al (2018) RNA-seq and flow-cytometry of conventional, scalp, and palmoplantar psoriasis reveal shared and distinct molecular pathways. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-018-29472-w","journal-title":"Sci Rep"},{"issue":"23","key":"4830_CR4","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.1080\/14786419.2017.1292270","volume":"31","author":"Y Amen","year":"2017","unstructured":"Amen Y et al (2017) Melanogenesis inhibitors from Coix lacryma-jobi seeds in B16\u2013F10 melanoma cells. Nat Prod Res 31(23):2712\u20132718","journal-title":"Nat Prod Res"},{"key":"4830_CR5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006","author":"AW Armstrong","year":"2020","unstructured":"Armstrong AW, Read C (2020) Pathophysiology, clinical presentation, and treatment of psoriasis. JAMA. https:\/\/doi.org\/10.1001\/jama.2020.4006","journal-title":"JAMA"},{"key":"4830_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3542-0","volume-title":"The mitotic spindle\u202f: methods and protocols","author":"P Chang","year":"2016","unstructured":"Chang P, Ohi R (2016) The mitotic spindle\u202f: methods and protocols. Humana Press, New York"},{"key":"4830_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.800283","author":"S Chen","year":"2022","unstructured":"Chen S et al (2022) Topical application of tetrandrine nanoemulsion promotes the expansion of CD4+Foxp3+ regulatory T cells and alleviates imiquimod-induced psoriasis in mice. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2022.800283","journal-title":"Front Immunol"},{"key":"4830_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112246","author":"C-C Chiang","year":"2020","unstructured":"Chiang C-C et al (2020) Kan-Lu-Hsiao-Tu-Tan, a traditional Chinese medicine formula, inhibits human neutrophil activation and ameliorates imiquimod-induced psoriasis-like skin inflammation. J Ethnopharmacol. https:\/\/doi.org\/10.1016\/j.jep.2019.112246","journal-title":"J Ethnopharmacol"},{"key":"4830_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2020.155357","author":"B Ehst","year":"2021","unstructured":"Ehst B et al (2021) Synergistic induction of IL-23 by TNF\u03b1, IL-17A, and EGF in keratinocytes. Cytokine. https:\/\/doi.org\/10.1016\/j.cyto.2020.155357","journal-title":"Cytokine"},{"key":"4830_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/s40246-018-0158-2","author":"T Elango","year":"2018","unstructured":"Elango T et al (2018) Mutational analysis of epidermal and hyperproliferative type I keratins in mild and moderate psoriasis vulgaris patients: a possible role in the pathogenesis of psoriasis along with disease severity. Hum Genomics. https:\/\/doi.org\/10.1186\/s40246-018-0158-2","journal-title":"Hum Genomics"},{"issue":"1","key":"4830_CR11","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.ajhg.2012.05.010","volume":"91","author":"D Fuchs-Telem","year":"2012","unstructured":"Fuchs-Telem D et al (2012) Familial pityriasis rubra pilaris is caused by mutations in CARD14. Am J Hum Genet 91(1):163\u2013170","journal-title":"Am J Hum Genet"},{"issue":"6","key":"4830_CR12","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1136\/annrheumdis-2012-201978","volume":"72","author":"W Gao","year":"2013","unstructured":"Gao W et al (2013) Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2. Ann Rheum Dis 72(6):1080\u20131088","journal-title":"Ann Rheum Dis"},{"key":"4830_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2024.119881","author":"S Ghorbanalipoor","year":"2025","unstructured":"Ghorbanalipoor S et al (2025) The loss of keratin 77 in murine skin is functionally compensated by keratin 1. Biochimica Et Biophysica Acta (BBA) - Molecular Cell Research. https:\/\/doi.org\/10.1016\/j.bbamcr.2024.119881","journal-title":"Biochimica Et Biophysica Acta (BBA) - Molecular Cell Research"},{"key":"4830_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2025.116794","author":"D-L Huang","year":"2025","unstructured":"Huang D-L et al (2025) Yi-qi-yang-yin decoction ameliorates diabetic retinopathy: new and comprehensive evidence from network pharmacology, machine learning, molecular docking and molecular biology experiment. J Pharm Biomed Anal. https:\/\/doi.org\/10.1016\/j.jpba.2025.116794","journal-title":"J Pharm Biomed Anal"},{"key":"4830_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020335","author":"H-Y Hung","year":"2022","unstructured":"Hung H-Y et al (2022) Chemical constituents of Hedyotis diffusa and their anti-inflammatory bioactivities. Antioxidants. https:\/\/doi.org\/10.3390\/antiox11020335","journal-title":"Antioxidants"},{"issue":"2","key":"4830_CR16","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1002\/med.21291","volume":"34","author":"L Jin","year":"2014","unstructured":"Jin L, Wang G (2014) Keratin 17: a critical player in the pathogenesis of psoriasis. Med Res Rev 34(2):438\u2013454","journal-title":"Med Res Rev"},{"key":"4830_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.105699","author":"D Kong","year":"2024","unstructured":"Kong D et al (2024) Interaction of human dendritic cell receptor DEC205\/CD205 with keratins. J Biol Chem. https:\/\/doi.org\/10.1016\/j.jbc.2024.105699","journal-title":"J Biol Chem"},{"issue":"3","key":"4830_CR18","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s00441-013-1716-5","volume":"354","author":"L Langbein","year":"2013","unstructured":"Langbein L et al (2013) New facets of keratin K77: interspecies variations of expression and different intracellular location in embryonic and adult skin of humans and mice. Cell Tissue Res 354(3):793\u2013812","journal-title":"Cell Tissue Res"},{"key":"4830_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/biology11071013","author":"SG Lee","year":"2022","unstructured":"Lee SG et al (2022) Nidus vespae built by an invasive alien hornet, Vespa velutina nigrithorax, inhibits adipose tissue expansion in high-fat diet-induced obese mice. Biology. https:\/\/doi.org\/10.3390\/biology11071013","journal-title":"Biology"},{"key":"4830_CR20","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202201560","author":"D Lukac","year":"2022","unstructured":"Lukac D et al (2022) Emetine blocks DNA replication via proteosynthesis inhibition not by targeting Okazaki fragments. Life Sci Alliance. https:\/\/doi.org\/10.26508\/lsa.202201560","journal-title":"Life Sci Alliance"},{"key":"4830_CR21","first-page":"1","volume":"2021","author":"M Luo","year":"2021","unstructured":"Luo M et al (2021) Kochia scoparia saponin momordin Ic modulates HaCaT cell proliferation and apoptosis via the Wnt\/\u03b2-catenin pathway. Evid Based Complement Alternat Med 2021:1\u20138","journal-title":"Evid Based Complement Alternat Med"},{"key":"4830_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.117856","author":"S Man","year":"2024","unstructured":"Man S et al (2024) Evaluating the efficacy and mechanisms of Hua-Zhuo-Ning-Fu-decoction on psoriasis using integrated bioinformatics analysis and metabolomics. J Ethnopharmacol. https:\/\/doi.org\/10.1016\/j.jep.2024.117856","journal-title":"J Ethnopharmacol"},{"issue":"08","key":"4830_CR23","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1142\/S0192415X21500889","volume":"49","author":"Z Mu","year":"2021","unstructured":"Mu Z et al (2021) Therapeutic effects of shikonin on skin diseases: a review. Am J Chin Med 49(08):1871\u20131895","journal-title":"Am J Chin Med"},{"key":"4830_CR24","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-958005","author":"K M\u00fcller","year":"1995","unstructured":"M\u00fcller K et al (1995) The antipsoriatic Mahonia aqutfolium and its active constituents; II. Antiproliferative activity against cell growth of human keratinocytes. Planta Med. https:\/\/doi.org\/10.1055\/s-2006-958005","journal-title":"Planta Med"},{"issue":"2","key":"4830_CR25","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1002\/JLB.5MR0120-439R","volume":"108","author":"X Ni","year":"2020","unstructured":"Ni X, Lai Y (2020) Keratinocyte: a trigger or an executor of psoriasis? J Leukoc Biol 108(2):485\u2013491","journal-title":"J Leukoc Biol"},{"issue":"12","key":"4830_CR26","doi-asserted-by":"publisher","first-page":"a017772","DOI":"10.1101\/cshperspect.a017772","volume":"3","author":"C Nowell","year":"2013","unstructured":"Nowell C, Radtke F (2013) Cutaneous notch signaling in health and disease. Cold Spring Harb Perspect Med 3(12):a017772\u2013a017772","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"7","key":"4830_CR27","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.tibs.2006.05.008","volume":"31","author":"MB Omary","year":"2006","unstructured":"Omary MB et al (2006) \u2018Heads and tails\u2019 of intermediate filament phosphorylation: multiple sites and functional insights. Trends Biochem Sci 31(7):383\u2013394","journal-title":"Trends Biochem Sci"},{"issue":"10","key":"4830_CR28","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1016\/j.yexcr.2007.04.009","volume":"313","author":"DAD Parry","year":"2007","unstructured":"Parry DAD et al (2007) Towards a molecular description of intermediate filament structure and assembly. Exp Cell Res 313(10):2204\u20132216","journal-title":"Exp Cell Res"},{"issue":"7","key":"4830_CR29","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1089\/acm.2012.0314","volume":"18","author":"N Pazyar","year":"2012","unstructured":"Pazyar N, Jamshydian N (2012) Cepharanthine: a therapeutic potential candidate for psoriasis. J Altern Complement Med 18(7):639\u2013640","journal-title":"J Altern Complement Med"},{"key":"4830_CR30","doi-asserted-by":"publisher","first-page":"5209","DOI":"10.2147\/DDDT.S523836","volume":"19","author":"Y Qiao","year":"2025","unstructured":"Qiao Y et al (2025) Multi-target mechanism of compound Qingdai capsule for treatment of psoriasis: multi-omics analysis and experimental verification. Drug des Devel Ther 19:5209\u20135230","journal-title":"Drug des Devel Ther"},{"issue":"2","key":"4830_CR31","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/exd.12306","volume":"23","author":"P Rooney","year":"2014","unstructured":"Rooney P et al (2014) Notch-1 mediates endothelial cell activation and invasion in psoriasis. Exp Dermatol 23(2):113\u2013118","journal-title":"Exp Dermatol"},{"key":"4830_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2023.107436","author":"P Sarker","year":"2023","unstructured":"Sarker P et al (2023) Identification of potential novel therapeutic drug target against Elizabethkingia anophelis by integrative pan and subtractive genomic analysis: an in silico approach. Comput Biol Med. https:\/\/doi.org\/10.1016\/j.compbiomed.2023.107436","journal-title":"Comput Biol Med"},{"issue":"18","key":"4830_CR33","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1056\/NEJMra041320","volume":"352","author":"MP Sch\u00f6n","year":"2005","unstructured":"Sch\u00f6n MP, Boehncke WH (2005) Psoriasis. N Engl J Med 352(18):1899\u20131912","journal-title":"N Engl J Med"},{"issue":"11","key":"4830_CR34","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1210\/me.2010-0183","volume":"24","author":"LM Sevilla","year":"2010","unstructured":"Sevilla LM et al (2010) Glucocorticoid receptor regulates overlapping and differential gene subsets in developing and adult skin. Mol Endocrinol 24(11):2166\u20132178","journal-title":"Mol Endocrinol"},{"issue":"5","key":"4830_CR35","doi-asserted-by":"publisher","first-page":"348","DOI":"10.5001\/omj.2012.90","volume":"27","author":"S Shetty","year":"2012","unstructured":"Shetty S, Gokul S (2012) Keratinization and its disorders. Oman Med J 27(5):348\u2013357","journal-title":"Oman Med J"},{"issue":"3","key":"4830_CR36","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1182\/blood-2011-02-334995","volume":"118","author":"K Shibata","year":"2011","unstructured":"Shibata K et al (2011) Notch-Hes1 pathway is required for the development of IL-17\u2013producing \u03b3\u03b4 T cells. Blood 118(3):586\u2013593","journal-title":"Blood"},{"key":"4830_CR37","doi-asserted-by":"crossref","unstructured":"Smack DP et al (1994) <keratin and keratinization source j am acad dermatol 1994 jan 30 1 85 102.pdf>. Journal of the American Academy of Dermatology","DOI":"10.1016\/S0190-9622(94)70012-5"},{"issue":"1","key":"4830_CR38","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1093\/emph\/eoab042","volume":"9","author":"I Starr","year":"2021","unstructured":"Starr I et al (2021) Evolutionary context of psoriatic immune skin response. Evol Med Public Health 9(1):474\u2013486","journal-title":"Evol Med Public Health"},{"key":"4830_CR39","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-021-00550-y","author":"Y Su","year":"2021","unstructured":"Su Y et al (2021) A review of Chinese medicine for the treatment of psoriasis: principles, methods and analysis. Chin Med. https:\/\/doi.org\/10.1186\/s13020-021-00550-y","journal-title":"Chin Med"},{"key":"4830_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.141544","author":"NS Sulaiman","year":"2025","unstructured":"Sulaiman NS et al (2025) Duckweed protein: extraction, modification, and potential application. Food Chem. https:\/\/doi.org\/10.1016\/j.foodchem.2024.141544","journal-title":"Food Chem"},{"key":"4830_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70275-0","author":"T Sullivan","year":"1998","unstructured":"Sullivan T et al (1998) Colchicine in dermatology. J Am Acad Dermatol. https:\/\/doi.org\/10.1016\/S0190-9622(98)70275-0","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"4830_CR42","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1007\/s12029-014-9648-1","volume":"45","author":"S Taleb","year":"2014","unstructured":"Taleb S et al (2014) HES1 as an independent prognostic marker in esophageal squamous cell carcinoma. J Gastrointest Cancer 45(4):466\u2013471","journal-title":"J Gastrointest Cancer"},{"key":"4830_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/foods13172685","author":"Y Tuo","year":"2024","unstructured":"Tuo Y et al (2024) The potential mechanisms of catechins in tea for anti-hypertension: an integration of network pharmacology, molecular docking, and molecular dynamics simulation. Foods. https:\/\/doi.org\/10.3390\/foods13172685"},{"issue":"3","key":"4830_CR44","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s40257-017-0338-1","volume":"19","author":"D Wang","year":"2018","unstructured":"Wang D et al (2018) A review on pityriasis rubra pilaris. Am J Clin Dermatol 19(3):377\u2013390","journal-title":"Am J Clin Dermatol"},{"key":"4830_CR45","first-page":"1","volume":"2020","author":"Y Wang","year":"2020","unstructured":"Wang Y et al (2020) Notch-Hes1 signaling regulates IL-17A+\u03b3\u03b4+T cell expression and IL-17A secretion of mouse psoriasis-like skin inflammation. Mediators Inflamm 2020:1\u20139","journal-title":"Mediators Inflamm"},{"key":"4830_CR46","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1340467","author":"S Wang","year":"2024","unstructured":"Wang S et al (2024) Roles of tumor necrosis factor-like ligand 1A in \u03b3\u03b4T-cell activation and psoriasis pathogenesis. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2024.1340467","journal-title":"Front Immunol"},{"key":"4830_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115826","author":"P Xiang","year":"2023","unstructured":"Xiang P et al (2023) Xiehuo xiaoying decoction inhibits Tfh cell expansion and promotes Tfr cell amplification to ameliorate Graves\u2019 disease. J Ethnopharmacol. https:\/\/doi.org\/10.1016\/j.jep.2022.115826","journal-title":"J Ethnopharmacol"},{"key":"4830_CR48","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.fitote.2019.03.026","volume":"134","author":"S Yang","year":"2019","unstructured":"Yang S et al (2019) Anti-inflammatory constituents from cortex dictamni. Fitoterapia 134:465\u2013473","journal-title":"Fitoterapia"},{"key":"4830_CR49","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-024-01009-6","author":"C Yongzhong","year":"2024","unstructured":"Yongzhong C et al (2024) Mechanism of jianxin granules in the treatment of heart failure based on proteomics and metabolomics. Chin Med. https:\/\/doi.org\/10.1186\/s13020-024-01009-6","journal-title":"Chin Med"},{"key":"4830_CR50","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.intimp.2018.09.048","volume":"65","author":"J Zhang","year":"2018","unstructured":"Zhang J et al (2018) Gallic acid inhibits the expression of keratin 16 and keratin 17 through Nrf2 in psoriasis-like skin disease. Int Immunopharmacol 65:84\u201395","journal-title":"Int Immunopharmacol"},{"issue":"06","key":"4830_CR51","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1142\/S0192415X22500616","volume":"50","author":"H Zheng","year":"2022","unstructured":"Zheng H et al (2022) Research advances in lotus leaf as Chinese dietary herbal medicine. Am J Chin Med 50(06):1423\u20131445","journal-title":"Am J Chin Med"},{"key":"4830_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112826","author":"D Zhou","year":"2020","unstructured":"Zhou D et al (2020) TMT-based proteomics analysis reveals the protective effects of Xuefu Zhuyu decoction in a rat model of traumatic brain injury. J Ethnopharmacol. https:\/\/doi.org\/10.1016\/j.jep.2020.112826","journal-title":"J Ethnopharmacol"},{"key":"4830_CR53","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04523-3","author":"X Zhou","year":"2022","unstructured":"Zhou X et al (2022) Advances in the pathogenesis of psoriasis: from keratinocyte perspective. Cell Death Dis. https:\/\/doi.org\/10.1038\/s41419-022-04523-3","journal-title":"Cell Death Dis"},{"key":"4830_CR54","doi-asserted-by":"publisher","DOI":"10.4314\/ajtcam.v10i4.28","author":"X Zhou","year":"2013","unstructured":"Zhou X et al (2013) A study of extraction process and in vitro antioxidant activity of total phenols from Rhizoma imperatae. Afr J Tradit Complement Altern Med. https:\/\/doi.org\/10.4314\/ajtcam.v10i4.28","journal-title":"Afr J Tradit Complement Altern Med"},{"key":"4830_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153644","author":"W Zou","year":"2021","unstructured":"Zou W et al (2021) Imperatae rhizoma-Hedyotis diffusa Willd. herbal pair alleviates nephrotic syndrome by integrating anti-inflammatory and hypolipidaemic effects. Phytomedicine. https:\/\/doi.org\/10.1016\/j.phymed.2021.153644","journal-title":"Phytomedicine"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04830-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04830-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04830-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T06:51:35Z","timestamp":1775458295000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04830-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,5]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["4830"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04830-4","relation":{"references":[{"id-type":"doi","id":"10.3390\/foods13172685","asserted-by":"subject"}]},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,5]]},"assertion":[{"value":"24 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}