{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T19:50:13Z","timestamp":1775505013380,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Beijing City University Sailing Fund","award":["KYQH202436"],"award-info":[{"award-number":["KYQH202436"]}]},{"name":"Beijing City University Student Innovation and Entrepreneurship Training Program","award":["202511418019"],"award-info":[{"award-number":["202511418019"]}]},{"name":"Beijing City University Team Fund Project","award":["KYTD202401"],"award-info":[{"award-number":["KYTD202401"]}]},{"name":"National Natural Science Foundation of China Young Scientist Fund Project Category C","award":["82505048"],"award-info":[{"award-number":["82505048"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s00210-025-04857-7","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T22:35:20Z","timestamp":1764887720000},"page":"7131-7148","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrative bioinformatics and machine learning to explore the mechanism of Scutellaria baicalensis Georgi in TGF-\u03b21-induced ASMCs proliferation during asthma airway remodeling"],"prefix":"10.1007","volume":"399","author":[{"given":"Yue","family":"Ren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minxuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sihan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linghe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"4857_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/biostatistics\/kxab030","volume":"24","author":"TA Alexander","year":"2022","unstructured":"Alexander TA, Irizarry RA, Bravo HC (2022) Capturing discrete latent structures: choose LDs over PCs. Biostatistics 24:1\u201316","journal-title":"Biostatistics"},{"key":"4857_CR2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/MCP.0000000000000228","volume":"22","author":"C Andersson","year":"2016","unstructured":"Andersson C, Tufvesson E, Diamant Z, Bjermer L (2016) Revisiting the role of the mast cell in asthma. Curr Opin Pulm Med 22:10\u201317","journal-title":"Curr Opin Pulm Med"},{"key":"4857_CR3","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1016\/j.jaci.2021.03.035","volume":"147","author":"B Camoretti-Mercado","year":"2021","unstructured":"Camoretti-Mercado B, Lockey RF (2021) Airway smooth muscle pathophysiology in asthma. J Allergy Clin Immunol 147:1983\u20131996","journal-title":"J Allergy Clin Immunol"},{"key":"4857_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104981","author":"Y Cao","year":"2020","unstructured":"Cao Y, Cao WJ, Qiu YM, Zhou YX, Guo QL, Gao Y, Lu N (2020) Oroxylin A suppresses ACTN1 expression to inactivate cancer-associated fibroblasts and restrain breast cancer metastasis. Pharmacol Res. https:\/\/doi.org\/10.1016\/j.phrs.2020.104981","journal-title":"Pharmacol Res"},{"key":"4857_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2022.105517","author":"K Chaieb","year":"2022","unstructured":"Chaieb K, Kouidhi B, Hosawi SB, Baothman OAS, Zamzami MA, Altayeb HN (2022) Computational screening of natural compounds as putative quorum sensing inhibitors targeting drug resistance bacteria: molecular docking and molecular dynamics simulations. Comput Biol Med. https:\/\/doi.org\/10.1016\/j.compbiomed.2022.105517","journal-title":"Comput Biol Med"},{"key":"4857_CR6","doi-asserted-by":"crossref","unstructured":"Cheng YJ,\u00a0Yang X, Wang Y,\u00a0Li Q,\u00a0Chen WL,\u00a0Dai R,\u00a0Zhang C (2024) Multiple machine-learning tools identifying prognostic biomarkers for acute myeloid leukemia. Bmc Med Info Decision Making\u00a024.","DOI":"10.1186\/s12911-023-02408-9"},{"key":"4857_CR7","doi-asserted-by":"crossref","unstructured":"Chin CH,\u00a0Chen SH,\u00a0Wu HH,\u00a0Ho CW,\u00a0Ko MT,\u00a0Lin CY (2014) cytoHubba: identifying hub objects and sub-networks from complex interactome. Bmc Systems Biology\u00a08.","DOI":"10.1186\/1752-0509-8-S4-S11"},{"key":"4857_CR8","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.coph.2020.07.004","volume":"51","author":"S Conaway","year":"2020","unstructured":"Conaway S, Nayak AP, Deshpande DA (2020) Therapeutic potential and challenges of bitter taste receptors on lung cells. Curr Opin Pharmacol 51:43\u201349","journal-title":"Curr Opin Pharmacol"},{"key":"4857_CR9","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1016\/j.biopha.2018.08.127","volume":"107","author":"WT Deng","year":"2018","unstructured":"Deng WT, Han W, Fan T, Wang XK, Cheng Z, Wan B, Chen JL (2018) Scutellarin inhibits human renal cancer cell proliferation and migration via upregulation of PTEN. Biomed Pharmacother 107:1505\u20131513","journal-title":"Biomed Pharmacother"},{"key":"4857_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00246","author":"SC Dharmage","year":"2019","unstructured":"Dharmage SC, Perret JL, Custovic A (2019) Epidemiology of asthma in children and adults. Front Pediatr. https:\/\/doi.org\/10.3389\/fped.2019.00246","journal-title":"Front Pediatr"},{"key":"4857_CR11","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.mucimm.2025.03.003","volume":"18","author":"D Dorscheid","year":"2025","unstructured":"Dorscheid D, Gauvreau GM, Georas SN, Hiemstra PS, Varricchi G, Lambrecht BN, Marone G (2025) Airway epithelial cells as drivers of severe asthma pathogenesis. Mucosal Immunol 18:524\u2013536","journal-title":"Mucosal Immunol"},{"key":"4857_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.107858","author":"WJ Fan","year":"2020","unstructured":"Fan WJ, Liu YZ, Li CY, Qu XF, Zheng GF, Zhang Q, Pan ZC, Wang YL, Rong JJ (2020) MicroRNA-331-3p maintains the contractile type of vascular smooth muscle cells by regulating TNF-\u03b1 and CD14 in intracranial aneurysm. Neuropharmacology. https:\/\/doi.org\/10.1016\/j.neuropharm.2019.107858","journal-title":"Neuropharmacology"},{"key":"4857_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2022.852067","author":"AS Flores-Torres","year":"2022","unstructured":"Flores-Torres AS, Samarasinghe AE (2022) Impact of therapeutics on unified immunity during allergic asthma and respiratory infections. Front Allergy. https:\/\/doi.org\/10.3389\/falgy.2022.852067","journal-title":"Front Allergy"},{"key":"4857_CR14","doi-asserted-by":"crossref","unstructured":"Ford ML,\u00a0Reza MI,\u00a0Ruwanpathirana A,\u00a0Sathish V,\u00a0Britt RD (2025) Integrative roles of pro-inflammatory cytokines on airway smooth muscle structure and function in asthma. Immun Rev, 330.","DOI":"10.1111\/imr.70007"},{"key":"4857_CR15","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1016\/j.jaci.2020.04.010","volume":"145","author":"PW Hellings","year":"2020","unstructured":"Hellings PW, Steelant B (2020) Epithelial barriers in allergy and asthma. J Allergy Clin Immunol 145:1499\u20131509","journal-title":"J Allergy Clin Immunol"},{"key":"4857_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/cells10061389","author":"I Janulaityte","year":"2021","unstructured":"Janulaityte I, Januskevicius A, Kalinauskaite-Zukauske V, Palacionyte J, Malakauskas K (2021) Asthmatic eosinophils promote contractility and migration of airway smooth muscle cells and pulmonary fibroblasts in vitro. Cells. https:\/\/doi.org\/10.3390\/cells10061389","journal-title":"Cells"},{"key":"4857_CR17","doi-asserted-by":"publisher","first-page":"12361","DOI":"10.1039\/D3RA01661G","volume":"13","author":"EM Kamel","year":"2023","unstructured":"Kamel EM, Bin-Ammar A, El-Bassuony AA, Alanazi MM, Altharawi A, Ahmeda AF, Alanazi AS, Lamsabhi A, Mahmoud AM (2023) Molecular modeling and DFT studies on the antioxidant activity of Centaurea scoparia flavonoids and molecular dynamics simulation of their interaction with \u03b2-lactoglobulin. Rsc Advances 13:12361\u201374","journal-title":"Rsc Advances"},{"key":"4857_CR18","doi-asserted-by":"crossref","unstructured":"Lando V,\u00a0Calciano L,\u00a0Minelli C,\u00a0Bombieri C,\u00a0Ferrari M,\u00a0Malerba G,\u00a0Margagliotti A,\u00a0Murgia N,\u00a0 Nicolis M,\u00a0Olivieri M,\u00a0Potts J,\u00a0Tardivo S,\u00a0Accordini S (2023) IL18 gene polymorphism is associated with total IgE in adult subjects with asthma. J Clin Med\u00a012.","DOI":"10.3390\/jcm12123963"},{"key":"4857_CR19","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.ydbio.2007.12.021","volume":"315","author":"S Langton","year":"2008","unstructured":"Langton S, Gudas LJ (2008) CYP26A1 knockout embryonic stem cells exhibit reduced differentiation and growth arrest in response to retinoic acid. Dev Biol 315:331\u2013354","journal-title":"Dev Biol"},{"key":"4857_CR20","first-page":"12557","volume":"8","author":"LH Li","year":"2015","unstructured":"Li LH, Lu B, Wu HK, Zhang H, Yao FF (2015) Apigenin inhibits TGF-\u03b21-induced proliferation and migration of airway smooth muscle cells. Int J Clin Exp Pathol 8:12557\u201312563","journal-title":"Int J Clin Exp Pathol"},{"key":"4857_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118592","author":"BY Li","year":"2024","unstructured":"Li BY, Zheng LL, Yuan AL, Ren Y, Xu ZZ, Liu YX, Tian JY, Yu B, Shi XJ, Qiao LS, Zhang YL (2024) Mechanism analysis of essential oil from Radix bupleuri for the treatment of asthma through regulation of ectopic olfactory receptor. J Ethnopharmacol. https:\/\/doi.org\/10.1016\/j.jep.2024.118592","journal-title":"J Ethnopharmacol"},{"key":"4857_CR22","doi-asserted-by":"crossref","unstructured":"Li J,\u00a0Xu WL,\u00a0Zhang SJ,\u00a0Zhao YN,\u00a0Shi ZC, Wang D,\u00a0Wang JL,\u00a0Sun LQ,\u00a0Zhao M (2024) Chemical constituents from the leaves of Scutellaria baicalensis Georgi and their chemotaxonomic significance. Biochem System Ecol, 116.","DOI":"10.1016\/j.bse.2024.104885"},{"key":"4857_CR23","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1007\/s10753-023-01947-7","volume":"47","author":"MF Li","year":"2024","unstructured":"Li MF, Jia D, Li JS, Li YQ, Wang YQ, Wang YT, Xie W, Chen S (2024) Scutellarin alleviates ovalbumin-induced airway remodeling in mice and TGF-\u03b2-induced pro-fibrotic phenotype in human bronchial epithelial cells via MAPK and Smad2\/3 signaling pathways. Inflammation 47:853\u2013873","journal-title":"Inflammation"},{"key":"4857_CR24","doi-asserted-by":"crossref","unstructured":"Liu Y,\u00a0Gao ZX,\u00a0Zhao YT,\u00a0Kong LJ,\u00a0Ji XQ,\u00a0Wu JY,\u00a0Gao ZH (2024) Exploring bioactive constituents and pharmacological effects of Scutellaria baicalensis Georgi: a review. Natural Product Commun, 19.","DOI":"10.1177\/1934578X241266692"},{"key":"4857_CR25","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1097\/MOO.0000000000000262","volume":"24","author":"PA Loftus","year":"2016","unstructured":"Loftus PA, Wise SK (2016) Epidemiology of asthma. Curr Opin Otolaryngol Head Neck Surg 24:245\u2013249","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"4857_CR26","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-2044-2","author":"JJ Luan","year":"2019","unstructured":"Luan JJ, Fu JQ, Chen CJ, Jiao CC, Kong WW, Zhang YX, Chang Q, Wang YQ, Li DT, Illei GG, Kopp JB, Pi JB, Zhou H (2019) LNA-anti-miR-150 ameliorated kidney injury of lupus nephritis by inhibiting renal fibrosis and macrophage infiltration. Arthritis Res Ther. https:\/\/doi.org\/10.1186\/s13075-019-2044-2","journal-title":"Arthritis Res Ther"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04857-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04857-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04857-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T19:01:54Z","timestamp":1775502114000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04857-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,4]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["4857"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04857-7","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,4]]},"assertion":[{"value":"22 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study involving rats was approved by the Medical and Experimental Animal Ethics Committee of BUCM (Approval No. BUCM-2023032009\u20131053).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}