{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T19:49:49Z","timestamp":1775504989581,"version":"3.50.1"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s00210-025-04858-6","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T07:20:18Z","timestamp":1765178418000},"page":"7323-7338","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combining anxiolytic activity of thymol and trans-ferulic acid: a potential GABAergic intervention"],"prefix":"10.1007","volume":"399","author":[{"given":"Md. Hanif","family":"Munshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noshin Tasnim","family":"Yana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imam Hossen","family":"Rakib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emon","family":"Mia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nusrat Jahan","family":"Tohfa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Sakib","family":"Al Hasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md Abu","family":"Sayeed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mst. Sumaia","family":"Akter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Arif","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Torequl","family":"Islam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Shimul","family":"Bhuia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mushtaq Ahmad","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"4858_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-025-03984-5","author":"S Ahammed","year":"2025","unstructured":"Ahammed S, Chowdhury R, Al Hasan MS, Mia E, Akbor MS, Islam MT, Chowdhury RI, Hossain MS, Ansari IA, Ansari SA, Islam MA, Almarhoon ZM, Sharifi-Rad J, Setzer WN, Islam MT (2025) Anti-arthritic potential of linalool: in vitro, in vivo, and in silico mechanistic insights for safer therapeutic applications. NaunynSchmiedebergs Arch Pharmacol. https:\/\/doi.org\/10.1007\/s00210-025-03984-5","journal-title":"NaunynSchmiedebergs Arch Pharmacol"},{"issue":"3","key":"4858_CR2","first-page":"31","volume":"7","author":"AH Ahmed","year":"2019","unstructured":"Ahmed AH, Alkali YI (2019) In silico pharmacokinetics and molecular docking studies of lead compounds derived from Diospyros mespiliformis. Pharm Tutor 7(3):31\u201337","journal-title":"Pharm Tutor"},{"key":"4858_CR3","doi-asserted-by":"publisher","unstructured":"Ahmmed MS, Hossan R, Ripu TR, Rahman T, Alshahrani MY, Mia E, Islam MT (2025) Assessment of antiemetic potential of schaftoside through modulation of dopaminergic, serotonergic and muscarinic signaling pathways: in vivo and in silico investigations. Naunyn Schmiedeberg's Arch Pharmacol 1\u201317. https:\/\/doi.org\/10.1007\/s00210-025-04714-7","DOI":"10.1007\/s00210-025-04714-7"},{"key":"4858_CR4","doi-asserted-by":"crossref","unstructured":"Akbor MS, Bappi MH, Prottay AA, Haque MF, Al Hasan MS, Ahammed S, Islam MT (2023) Synergistic hypnotic effects of sesamol and thymol possibly through gabaergic interaction pathway: in vivo and in silico studies. J Biol Regul Homeost Agents, 37(11):6419\u20136435","DOI":"10.23812\/j.biol.regul.homeost.agents.20233711.609"},{"key":"4858_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroscience.2025.03.004","volume":"572","author":"MS Al Hasan","year":"2025","unstructured":"Al Hasan MS, Bhuia MS, Chowdhury R, Husain Z, Saifuzzaman M, Mia E, Akbor MS, Yana NT, Islam MA, Ansari SA, Ansari IA, Islam MT (2025) Tangeretin enhances sedative activity of diazepam in Swiss mice through GABAA receptor interaction: in vivo and in silico approaches. Neuroscience 572:1\u201310. https:\/\/doi.org\/10.1016\/j.neuroscience.2025.03.004","journal-title":"Neuroscience"},{"issue":"8","key":"4858_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-025-02844-9","volume":"42","author":"MS Al Hasan","year":"2025","unstructured":"Al Hasan MS, Emon Y, Alshahrani MY, Mizan M, Uddin MB, Hasan AMW, Sayeed MA, Mia E, Yana NT, Hossan R, Islam MT (2025) Coumarin derivatives as anticancer agents targeting PI3K-AKT-mTOR pathway: a comprehensive literature review. Med Oncol 42(8):301. https:\/\/doi.org\/10.1007\/s12032-025-02844-9","journal-title":"Med Oncol"},{"key":"4858_CR7","doi-asserted-by":"crossref","unstructured":"Al Hasan MS, Mia E, Yana NT, Rakib IH, Bhuia MS, Chowdhury R, Islam MT (2024) Allium cepa bioactive phytochemicals as potent ALK (Anaplastic lymphoma kinase) inhibitors and therapeutic agents against non-small cell lung cancer (NSCLC): a computational study. Pharmacol Res-Nat Prod 5:100124","DOI":"10.1016\/j.prenap.2024.100124"},{"issue":"1","key":"4858_CR8","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1111\/raq.12490","volume":"13","author":"M Alagawany","year":"2021","unstructured":"Alagawany M, Farag MR, Abdelnour SA, Elnesr SS (2021) A review on the beneficial effect of thymol on health and production of fish. Rev Aquacult 13(1):632\u2013641","journal-title":"Rev Aquacult"},{"issue":"1","key":"4858_CR9","first-page":"1","volume":"2","author":"QHA Aljelehawy","year":"2023","unstructured":"Aljelehawy QHA, Mohammadi S, Mohamadian E, Raji Mal Allah O, Mirzaei A, Ghahremanlou M (2023) Antimicrobial, anticancer, antidiabetic, antineurodegenerative, and antirheumatic activities of thymol: Clarification of mechanisms. Micro Nano Bio Aspects 2(1):1\u20137","journal-title":"Micro Nano Bio Aspects"},{"key":"4858_CR10","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.brainres.2012.01.070","volume":"1448","author":"AAC de Almeida","year":"2012","unstructured":"de Almeida AAC, Costa JP, de Carvalho RBF, de Sousa DP, de Freitas RM (2012) Evaluation of acute toxicity of a natural compound (+)-limonene epoxide and its anxiolytic-like action. Brain Res 1448:56\u201362","journal-title":"Brain Res"},{"key":"4858_CR11","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.bbr.2013.05.035","volume":"256","author":"AE Arrant","year":"2013","unstructured":"Arrant AE, Schramm-Sapyta NL, Kuhn CM (2013) Use of the light\/dark test for anxiety in adult and adolescent male rats. Behav Brain Res 256:119\u2013127","journal-title":"Behav Brain Res"},{"key":"4858_CR12","first-page":"66","volume":"1","author":"MA Aziz","year":"2016","unstructured":"Aziz MA, Sarkar KK, Akter MI (2016) Y-maze, elevated plus maze and hole cross tests of Richardia scabra whole plant. Pharmacol Online 1:66\u201372","journal-title":"Pharmacol Online"},{"issue":"2","key":"4858_CR13","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/S2221-6189(14)60030-5","volume":"3","author":"SS Bhandari","year":"2014","unstructured":"Bhandari SS, Kabra MP (2014) To evaluate anti-anxiety activity of thymol. J Acute Dis 3(2):136\u2013140","journal-title":"J Acute Dis"},{"key":"4858_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2024.107403","volume":"106","author":"MS Bhuia","year":"2024","unstructured":"Bhuia MS, Al Hasan MS, Chowdhury R, Ansari SA, Ansari IA, Islam MT (2024) Trans-ferulic acid reduces the sedative activity of diazepam in thiopental sodium-induced sleeping mice: a potential GABAergic transmission. Neurotoxicol Teratol 106:107403","journal-title":"Neurotoxicol Teratol"},{"key":"4858_CR15","doi-asserted-by":"crossref","unstructured":"Bhuia MS, Kamli H, Islam T, Sonia FA, Kazi MA, Siam MSH, Islam MT (2023a) Antiemetic activity of trans-ferulic acid possibly through muscarinic receptors interaction pathway: in vivo and in silico study. Results Chem 6:101014","DOI":"10.1016\/j.rechem.2023.101014"},{"key":"4858_CR16","doi-asserted-by":"crossref","unstructured":"Bhuia MS, Rokonuzzman M, Hossain MI, Ansari SA, Ansari IA, Islam T, Islam MT (2023b) Anxiolytic-like effects by trans-ferulic acid possibly occur through GABAergic interaction pathways. Pharmaceuticals 16(9):1271","DOI":"10.3390\/ph16091271"},{"issue":"1\u20133","key":"4858_CR17","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0014-2999(03)01274-3","volume":"463","author":"M Bourin","year":"2003","unstructured":"Bourin M, Hasco\u00ebt M (2003) The mouse light\/dark box test. Eur J Pharmacol 463(1\u20133):55\u201365","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"4858_CR18","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/jnc.15769","volume":"165","author":"A Bryson","year":"2023","unstructured":"Bryson A, Reid C, Petrou S (2023) Fundamental neurochemistry review: GABAA receptor neurotransmission and epilepsy: principles, disease mechanisms and pharmacotherapy. J Neurochem 165(1):6\u201328","journal-title":"J Neurochem"},{"key":"4858_CR19","doi-asserted-by":"crossref","unstructured":"Chen J, Lin D, Zhang C, Li G, Zhang N, Ruan L, Xu Y (2015) Antidepressant-like effects of ferulic acid: involvement of serotonergic and norepinergic systems. Metab Brain Dis 30:129\u2013136","DOI":"10.1007\/s11011-014-9635-z"},{"issue":"1","key":"4858_CR20","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/s41398-023-02514-2","volume":"13","author":"AJ Cutler","year":"2023","unstructured":"Cutler AJ, Mattingly GW, Maletic V (2023) Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder. Transl Psychiatry 13(1):228","journal-title":"Transl Psychiatry"},{"issue":"1","key":"4858_CR21","doi-asserted-by":"publisher","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"A Daina","year":"2017","unstructured":"Daina A, Michielin O, Zoete V (2017) SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Sci Rep 7(1):42717","journal-title":"Sci Rep"},{"issue":"13","key":"4858_CR22","doi-asserted-by":"publisher","first-page":"4885","DOI":"10.1002\/jsfa.9020","volume":"98","author":"L Deng","year":"2018","unstructured":"Deng L, Shi AM, Wang Q (2018) Sedative\u2013hypnotic and anxiolytic effects and the mechanism of action of aqueous extracts of peanut stems and leaves in mice. J Sci Food Agric 98(13):4885\u20134894","journal-title":"J Sci Food Agric"},{"key":"4858_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117856","volume":"255","author":"J Dhaliwal","year":"2020","unstructured":"Dhaliwal J, Dhaliwal N, Akhtar A, Kuhad A, Chopra K (2020) Beneficial effects of ferulic acid alone and in combination with insulin in streptozotocin induced diabetic neuropathy in Sprague Dawley rats. Life Sci 255:117856","journal-title":"Life Sci"},{"key":"4858_CR24","doi-asserted-by":"publisher","unstructured":"Fahmi AA, Akter K, Rakib IH, Hossain S, Alkhathami AG, Al Hasan MS, Islam MT (2025) Linalool exerts antiemetic effects via dopaminergic and serotonergic pathways: Evidence from chick model and molecular docking. Naunyn Schmiedeberg's Arch Pharmacol 1\u201311. https:\/\/doi.org\/10.1007\/s00210-025-04631-9","DOI":"10.1007\/s00210-025-04631-9"},{"key":"4858_CR25","doi-asserted-by":"crossref","unstructured":"Fedotova J, Kubatka P, B\u00fcsselberg D, Shleikin AG, Caprnda M, Dragasek J, Kruzliak P (2017) Therapeutical strategies for anxiety and anxiety-like disorders using plant-derived natural compounds and plant extracts. Biomed Pharmacother 95:437\u2013446","DOI":"10.1016\/j.biopha.2017.08.107"},{"issue":"1","key":"4858_CR26","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s43141-021-00224-0","volume":"19","author":"A Ghit","year":"2021","unstructured":"Ghit A, Assal D, Al-Shami AS, Hussein DEE (2021) GABAA receptors: structure, function, pharmacology, and related disorders. J Genet Eng Biotechnol 19(1):123","journal-title":"J Genet Eng Biotechnol"},{"issue":"7","key":"4858_CR27","doi-asserted-by":"publisher","first-page":"9225","DOI":"10.1007\/s00210-025-03860-2","volume":"398","author":"PR Ghosh","year":"2025","unstructured":"Ghosh PR, Al Hasan MS, Rouf R, Chowdhury R, Yadav B, Mia E, Islam MT, Hasan MR, Ansari SA, Ansari IA, Bhuia MS, Islam MT (2025) Assessments of protodioscin\u2019s antinociceptive and antidiarrheal properties: in vivo and in silico investigations on macromolecule binding affinity and modulatory effects. Naunyn Schmiedebergs Arch Pharmacol 398(7):9225. https:\/\/doi.org\/10.1007\/s00210-025-03860-2","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"4858_CR28","doi-asserted-by":"publisher","first-page":"113036","DOI":"10.1016\/j.jep.2020.113036","volume":"260","author":"ACM Hacke","year":"2020","unstructured":"Hacke ACM, Miyoshi E, Marques JA, Pereira RP (2020) Anxiolytic properties of Cymbopogon citratus (DC.) stapf extract, essential oil and its constituents in zebrafish (Danio rerio). J Ethnopharmacol 260:113036","journal-title":"J Ethnopharmacol"},{"key":"4858_CR29","doi-asserted-by":"publisher","DOI":"10.3329\/bjms.v20i3.52790","author":"M Haque","year":"2021","unstructured":"Haque M (2021) Anxiety disorders: recent global approach to neuro-pathogenesis, drug treatment, cognitive behavioral therapy, and their implications. Bangladesh J Med Sci. https:\/\/doi.org\/10.3329\/bjms.v20i3.52790","journal-title":"Bangladesh J Med Sci"},{"issue":"24","key":"4858_CR30","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.2106\/JBJS.22.00516","volume":"104","author":"BA Hozack","year":"2022","unstructured":"Hozack BA, Kistler JM, Vaccaro AR, Beredjiklian PK (2022) Benzodiazepines and related drugs in orthopaedics. J Bone Joint Surg 104(24):2204\u20132210","journal-title":"J Bone Joint Surg"},{"issue":"3","key":"4858_CR31","first-page":"62","volume":"3","author":"MT Islam","year":"2014","unstructured":"Islam MT, Freitas RD, Oliveira GDS, Guha B (2014) Neuropharmacological screenings of hydroalcoholic fractions of Urena lobata L. World J Pharm Pharmaceut Sci 3(3):62\u201371","journal-title":"World J Pharm Pharmaceut Sci"},{"issue":"5","key":"4858_CR32","doi-asserted-by":"publisher","first-page":"5757","DOI":"10.1007\/s00210-024-03665-9","volume":"398","author":"MT Islam","year":"2024","unstructured":"Islam MT, Al Hasan MS, Chowdhury R, Mia E, Rakib IH, Yana NT, El-Nashar HAS, Ansari SA, Ansari IA, Islam MA, Almarhoon ZM, Setzer WN, Sharifi-Rad J (2024) Unveiling the anxiolytic and analgesic effects of citronellal in Swiss mice: in vivo and in silico insights into COX and GABAA receptor pathways. Naunyn Schmiedebergs Arch Pharmacol 398(5):5757. https:\/\/doi.org\/10.1007\/s00210-024-03665-9","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"4858_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2024.138060","volume":"845","author":"MT Islam","year":"2025","unstructured":"Islam MT, Al Hasan MS, Ferdous J, Mia E, Yana NT, Ansari IA, Ansari SA, Islam MA, Coutinho HDM (2025b) GabaAergic sedative prospection of sclareol-linalool co-treatment: an antagonistic intervention through in vivo and in silico studies. Neurosci Lett 845:138060. https:\/\/doi.org\/10.1016\/j.neulet.2024.138060","journal-title":"Neurosci Lett"},{"key":"4858_CR34","doi-asserted-by":"crossref","unstructured":"Islam MS, Hossain R, Ahmed T, Rahaman MM, Al-Khafaji K, Khan RA, Islam MT (2022) Anxiolytic-like effect of quercetin possibly through GABA receptor interaction pathway: In vivo and in silico studies. Molecules 27(21):7149","DOI":"10.3390\/molecules27217149"},{"key":"4858_CR35","doi-asserted-by":"publisher","unstructured":"Islam MT, Al Hasan MS, Ferdous J, Yana NT, Mia E, Rakib IH,\u00a0Ansari IA, Ansari SA,\u00a0Islam MA, Bhuia MS (2025a) Caffeine and sclareol take the edge off the sedative effects of linalool, possibly through the GABAA interaction pathway: molecular insights through in vivo and in silico studies. Naunyn-Schmiedeberg's Arch Pharmacol 398(8):10997\u201311009. https:\/\/doi.org\/10.1007\/s00210-025-03915-4","DOI":"10.1007\/s00210-025-03915-4"},{"key":"4858_CR36","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-025-04309-2","author":"N Jahan","year":"2025","unstructured":"Jahan N, Mandal M, Rakib IH, Al Hasan MS, Mia E, Yana NT, Alfaifi M, Altemani FH, Hossan R, Sumaya UH, Hasan AMW, Sayeed MA, Mou MA, Islam MT, Bhuia MS (2025) Oleuropein modulates anti-inflammatory activity of celecoxib and ketoprofen through cyclooxygenase pathway: in vivo, in silico and pharmacokinetics approaches. Naunyn-Schmiedebergs Arch Pharmacol. https:\/\/doi.org\/10.1007\/s00210-025-04309-2","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"4858_CR37","first-page":"132","volume":"18","author":"JK Kim","year":"2019","unstructured":"Kim JK, Park SU (2019) A recent overview on the biological and pharmacological activities of ferulic acid. EXCLI J 18:132\u2013138","journal-title":"EXCLI J"},{"key":"4858_CR38","doi-asserted-by":"publisher","first-page":"113285","DOI":"10.1016\/j.jep.2020.113285","volume":"264","author":"YS Lin","year":"2021","unstructured":"Lin YS, Peng WH, Shih MF, Cherng JY (2021) Anxiolytic effect of an extract of Salvia miltiorrhiza Bunge (Danshen) in mice. J Ethnopharmacol 264:113285","journal-title":"J Ethnopharmacol"},{"key":"4858_CR39","doi-asserted-by":"crossref","unstructured":"Lorigooini Z, Nouri A, Mottaghinia F, Balali-Dehkordi S, Bijad E, Dehkordi SH, Amini-Khoei, H. (2021) Ferulic acid through mitigation of NMDA receptor pathway exerts anxiolytic-like effect in mouse model of maternal separation stress. J Basic Clin Physiol Pharmacol 32(1):20190263","DOI":"10.1515\/jbcpp-2019-0263"},{"key":"4858_CR40","doi-asserted-by":"crossref","unstructured":"Magro L, Faccini M, Leone R (2016) Lormetazepam addiction. In Neuropathology of drug addictions and substance misuse (pp. 273\u2013282). Academic Press, p 3","DOI":"10.1016\/B978-0-12-800634-4.00027-5"},{"issue":"11","key":"4858_CR41","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.3109\/13880209.2014.993041","volume":"53","author":"S Nagarajan","year":"2015","unstructured":"Nagarajan S, Chellappan DR, Chinnaswamy P, Thulasingam S (2015) Ferulic acid pretreatment mitigates MPTP-induced motor impairment and histopathological alterations in C57BL\/6 mice. Pharm Biol 53(11):1591\u20131601","journal-title":"Pharm Biol"},{"key":"4858_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00380","volume":"8","author":"MF Nagoor Meeran","year":"2017","unstructured":"Nagoor Meeran MF, Javed H, Al Taee H, Azimullah S, Ojha SK (2017) Pharmacological properties and molecular mechanisms of thymol: prospects for its therapeutic potential and pharmaceutical development. Front Pharmacol 8:380. https:\/\/doi.org\/10.3389\/fphar.2017.00380","journal-title":"Front Pharmacol"},{"issue":"8","key":"4858_CR43","first-page":"1727","volume":"27","author":"AA Ogbuta","year":"2023","unstructured":"Ogbuta AA, Given OT, Ebinistei P, Alexis EO, Wellington EO, Teke EC, Manda AE (2023) Protective effects of trans-ferulic acid on tamoxifen induced heptatic and renal oxidative stress in male Wister albino rat. J Appl Sci Environ Manage 27(8):1727\u20131732","journal-title":"J Appl Sci Environ Manage"},{"key":"4858_CR44","doi-asserted-by":"publisher","unstructured":"Qian X, Zhao X, Yu L, Yin Y, Zhang XD, Wang L, Li JX, Zhu Q, Luo JL (2023) Current status of GABA receptor subtypes in analgesia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 168, 115800. https:\/\/doi.org\/10.1016\/j.biopha.2023.115800","DOI":"10.1016\/j.biopha.2023.115800"},{"issue":"01","key":"4858_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.71193\/jpci.20250005","volume":"1","author":"IH Rakib","year":"2025","unstructured":"Rakib IH, Hossan R, Al Hasan MS, Yana NT, Safa FA, Sumaya UH (2025) Anticancer activity of scutellarein against several cancer types with possible mechanisms: a mini review. Journal of Phytochemical Insights 1(01):1\u20136. https:\/\/doi.org\/10.71193\/jpci.20250005","journal-title":"Journal of Phytochemical Insights"},{"issue":"10","key":"4858_CR46","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.70560","volume":"39","author":"IH Rakib","year":"2025","unstructured":"Rakib IH, Mia E, Al Hasan MS, Hossain MA, Kamli H, Altemani FH, Islam MT (2025) Exploring the anticancer properties of cinchonine: a comprehensive review of cellular and molecular mechanisms with botanical source and pharmacokinetics property. J Biochem Mol Toxicol 39(10):e70560. https:\/\/doi.org\/10.1002\/jbt.70560","journal-title":"J Biochem Mol Toxicol"},{"key":"4858_CR47","doi-asserted-by":"publisher","DOI":"10.1007\/s12247-021-09543-8","author":"A Rezaeiroshan","year":"2022","unstructured":"Rezaeiroshan A, Saeedi M, Morteza-Semnani K, Akbari J, Hedayatizadeh-Omran A, Goli H, Nokhodchi A (2022) Vesicular formation of trans-ferulic acid: an efficient approach to improve the radical scavenging and antimicrobial properties. J Pharm Innov. https:\/\/doi.org\/10.1007\/s12247-021-09543-8","journal-title":"J Pharm Innov"},{"issue":"6","key":"4858_CR48","doi-asserted-by":"publisher","first-page":"e0285584","DOI":"10.1371\/journal.pone.0285584","volume":"18","author":"AD Ritvo","year":"2023","unstructured":"Ritvo AD, Foster DE, Huff C, Finlayson AR, Silvernail B, Martin PR (2023) Long-term consequences of benzodiazepine-induced neurological dysfunction: a survey. PLoS ONE 18(6):e0285584","journal-title":"PLoS ONE"},{"key":"4858_CR49","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1007\/s12640-019-00099-7","volume":"37","author":"VF Salau","year":"2020","unstructured":"Salau VF, Erukainure OL, Ibeji CU, Olasehinde TA, Koorbanally NA, Islam MS (2020) Ferulic acid modulates dysfunctional metabolic pathways and purinergic activities, while stalling redox imbalance and cholinergic activities in oxidative brain injury. Neurotox Res 37:944\u2013955","journal-title":"Neurotox Res"},{"issue":"9","key":"4858_CR50","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1002\/ptr.6109","volume":"32","author":"B Salehi","year":"2018","unstructured":"Salehi B, Mishra AP, Shukla I, Sharifi-Rad M, Contreras MDM, Segura-Carretero A, Fathi H, Nasrabadi NN, Kobarfard F, Sharifi-Rad J (2018) Thymol, thyme, and other plant sources: health and potential uses. Phytother Res 32(9):1688\u20131706. https:\/\/doi.org\/10.1002\/ptr.6109","journal-title":"Phytother Res"},{"key":"4858_CR51","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s00210-013-0917-5","volume":"387","author":"J Sancheti","year":"2014","unstructured":"Sancheti J, Shaikh MF, Chaudhari R, Somani G, Patil S, Jain P, Sathaye S (2014) Characterization of anticonvulsant and antiepileptogenic potential of thymol in various experimental models. Naunyn Schmiedebergs Arch Pharmacol 387:59\u201366","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"11","key":"4858_CR52","doi-asserted-by":"publisher","first-page":"e582101119894","DOI":"10.33448\/rsd-v10i11.19894","volume":"10","author":"SMS Sborgi","year":"2021","unstructured":"Sborgi SMS, Fernandes LC, Santos AG, Ferro MM, Miyoshi E (2021) Anxiolytic activity of ferulic acid in the light-dark test in zebrafish. Research, Society and Development 10(11):e582101119894\u2013e582101119894","journal-title":"Research, Society and Development"},{"key":"4858_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.focha.2025.100930","volume":"6","author":"KK Sharma","year":"2025","unstructured":"Sharma KK, Al Hasan MS, Rouf R, Emon Y, Mia E, Hossan R, Islam MT (2025) Assessment of antiemetic and modulatory activity of dihydrocoumarin on copper sulfate induced emetic chicks: an in vivo investigation. Food Chemistry Advances 6:100930. https:\/\/doi.org\/10.1016\/j.focha.2025.100930","journal-title":"Food Chemistry Advances"},{"key":"4858_CR54","doi-asserted-by":"publisher","first-page":"2940","DOI":"10.1007\/s11064-017-2325-6","volume":"42","author":"T Singh","year":"2017","unstructured":"Singh T, Kaur T, Goel RK (2017) Ferulic acid supplementation for management of depression in epilepsy. Neurochem Res 42:2940\u20132948","journal-title":"Neurochem Res"},{"key":"4858_CR55","doi-asserted-by":"crossref","unstructured":"Stein DJ, Craske MG, Rothbaum BO, Chamberlain SR, Fineberg NA, Choi KW, Maj M (2021) The clinical characterization of the adult patient with an anxiety or related disorder aimed at personalization of management. World Psychiatry 20(3):336\u2013356","DOI":"10.1002\/wps.20919"},{"issue":"23","key":"4858_CR56","doi-asserted-by":"publisher","first-page":"12889","DOI":"10.3390\/ijms222312889","volume":"22","author":"M Stompor-Gor\u0105cy","year":"2021","unstructured":"Stompor-Gor\u0105cy M, Machaczka M (2021) Recent advances in biological activity, new formulations and prodrugs of ferulic acid. Int J Mol Sci 22(23):12889. https:\/\/doi.org\/10.3390\/ijms222312889","journal-title":"Int J Mol Sci"},{"issue":"37","key":"4858_CR57","first-page":"611","volume":"115","author":"A Str\u00f6hle","year":"2018","unstructured":"Str\u00f6hle A, Gensichen J, Domschke K (2018) The diagnosis and treatment of anxiety disorders. Dtsch Arztebl Int 115(37):611","journal-title":"Dtsch Arztebl Int"},{"key":"4858_CR58","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1590\/S0102-695X2008000400004","volume":"18","author":"N Subhan","year":"2008","unstructured":"Subhan N, Alam MA, Ahmed F, Shahid IJ, Nahar L, Sarker SD (2008) Bioactivity of Excoecaria agallocha. Rev Bras Farmacogn 18:521\u2013526","journal-title":"Rev Bras Farmacogn"},{"issue":"4","key":"4858_CR59","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.tins.2011.01.004","volume":"34","author":"KR Tan","year":"2011","unstructured":"Tan KR, Rudolph U, L\u00fcscher C (2011) Hooked on benzodiazepines: GABAA receptor subtypes and addiction. Trends Neurosci 34(4):188\u2013197","journal-title":"Trends Neurosci"},{"key":"4858_CR60","doi-asserted-by":"publisher","unstructured":"Kraeuter AK, Guest PC, Sarnyai Z (2019) The open field test for measuring locomotor activity and anxiety-like behavior.\u00a0Methods in molecular biology (Clifton, N.J.),\u00a01916, 99\u2013103. https:\/\/doi.org\/10.1007\/978-1-4939-8994-2_9","DOI":"10.1007\/978-1-4939-8994-2_9"},{"key":"4858_CR61","doi-asserted-by":"crossref","unstructured":"Veskovic J, Cvetkovic M, Tahirovic E, Zdravkovic M, Apostolovic S, Kosevic D, Duengen HD (2023) Depression, anxiety, and quality of life as predictors of rehospitalization in patients with chronic heart failure. BMC Cardiovasc Disord 23(1):525","DOI":"10.1186\/s12872-023-03500-8"},{"key":"4858_CR62","doi-asserted-by":"crossref","unstructured":"Xu Y, Lin D, Yu X, Xie X, Wang L, Lian L, Pan J (2016) The antinociceptive effects of ferulic acid on neuropathic pain: involvement of descending monoaminergic system and opioid receptors. Oncotarget 7(15):20455","DOI":"10.18632\/oncotarget.7973"},{"issue":"3","key":"4858_CR63","doi-asserted-by":"publisher","first-page":"e14248","DOI":"10.1111\/nmo.14248","volume":"34","author":"MG Zizzo","year":"2022","unstructured":"Zizzo MG, Cicio A, Raimondo S, Alessandro R, Serio R (2022) Age\u2010related differences of \u03b3\u2010aminobutyric acid (GABA) ergic transmission in human colonic smooth muscle. Neurogastroenterol Motil 34(3):e14248","journal-title":"Neurogastroenterol Motil"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04858-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04858-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04858-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T19:01:38Z","timestamp":1775502098000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04858-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,8]]},"references-count":63,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["4858"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04858-6","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,8]]},"assertion":[{"value":"19 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}