{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:12:04Z","timestamp":1778123524404,"version":"3.51.4"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s00210-025-04914-1","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T04:27:33Z","timestamp":1768969653000},"page":"9229-9243","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clarifying the mechanism of Curcumin in the treatment of neuropathic pain based on network pharmacology and molecular docking technology"],"prefix":"10.1007","volume":"399","author":[{"given":"Xiangnan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangdong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conghu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"4914_CR1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/978-3-030-56153-6_2","volume":"1291","author":"M Akaberi","year":"2021","unstructured":"Akaberi M, Sahebkar A, Emami SA (2021) Turmeric and curcumin: from traditional to modern medicine. Adv Exp Med Biol 1291:15\u201339","journal-title":"Adv Exp Med Biol"},{"key":"4914_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1486918","volume":"15","author":"S Akbar","year":"2024","unstructured":"Akbar S, Subhan F, Qamar R, Akbar A, Shahbaz N, Aamir M, Siddique N, Islam SU (2024) 6-hydroxyflavanone treats anxiety and chemotherapy-induced neuropathy in Sprague-Dawley rats. Front Pharmacol 15:1486918","journal-title":"Front Pharmacol"},{"key":"4914_CR3","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/978-1-4939-7000-1_26","volume":"1607","author":"SK Burley","year":"2017","unstructured":"Burley SK, Berman HM, Kleywegt GJ, Markley JL, Nakamura H, Velankar S (2017) Protein data bank (PDB): the single global macromolecular structure archive. Methods Mol Biol 1607:627\u2013641","journal-title":"Methods Mol Biol"},{"key":"4914_CR4","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1007\/s11655-013-1549-9","volume":"20","author":"H Cao","year":"2014","unstructured":"Cao H, Zheng JW, Li JJ, Meng B, Li J, Ge RS (2014) Effects of curcumin on pain threshold and on the expression of nuclear factor kappa B and CX3C receptor 1 after sciatic nerve chronic constrictive injury in rats. Chin J Integr Med 20:850\u2013856","journal-title":"Chin J Integr Med"},{"key":"4914_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21061975","author":"E Chainoglou","year":"2020","unstructured":"Chainoglou E, Hadjipavlou-Litina D (2020) Curcumin in health and diseases: Alzheimer\u2019s disease and curcumin analogues, derivatives, and hybrids. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21061975","journal-title":"Int J Mol Sci"},{"key":"4914_CR6","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1002\/med.21599","volume":"40","author":"MA Cinelli","year":"2020","unstructured":"Cinelli MA, Do HT, Miley GP, Silverman RB (2020) Inducible nitric oxide synthase: regulation, structure, and inhibition. Med Res Rev 40:158\u2013189","journal-title":"Med Res Rev"},{"key":"4914_CR7","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/bs.irn.2024.10.013","volume":"179","author":"CP Da","year":"2024","unstructured":"Da CP, Lapa J, Hosomi K, de Andrade DC (2024) Neuromodulation for neuropathic pain. Int Rev Neurobiol 179:471\u2013502","journal-title":"Int Rev Neurobiol"},{"key":"4914_CR8","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s40122-014-0024-4","volume":"3","author":"YX Di","year":"2014","unstructured":"Di YX, Hong C, Jun L, Renshan G, Qinquan L (2014) Curcumin attenuates mechanical and thermal hyperalgesia in chronic constrictive injury model of neuropathic pain. Pain Ther 3:59\u201369","journal-title":"Pain Ther"},{"key":"4914_CR9","doi-asserted-by":"publisher","first-page":"16953","DOI":"10.1002\/jcp.28411","volume":"234","author":"T Farkhondeh","year":"2019","unstructured":"Farkhondeh T, Samarghandian S, Pourbagher-Shahri AM, Sedaghat M (2019) The impact of curcumin and its modified formulations on Alzheimer\u2019s disease. J Cell Physiol 234:16953\u201316965","journal-title":"J Cell Physiol"},{"key":"4914_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.imr.2023.100968","volume":"12","author":"P Garodia","year":"2023","unstructured":"Garodia P, Hegde M, Kunnumakkara AB, Aggarwal BB (2023) Curcumin, inflammation, and neurological disorders: how are they linked? Integr Med Res 12:100968","journal-title":"Integr Med Res"},{"key":"4914_CR11","doi-asserted-by":"publisher","first-page":"W32","DOI":"10.1093\/nar\/gku293","volume":"42","author":"D Gfeller","year":"2014","unstructured":"Gfeller D, Grosdidier A, Wirth M, Daina A, Michielin O, Zoete V (2014) SwissTargetPrediction: a web server for target prediction of bioactive small molecules. Nucleic Acids Res 42:W32\u2013W38","journal-title":"Nucleic Acids Res"},{"key":"4914_CR12","doi-asserted-by":"publisher","first-page":"9183","DOI":"10.3390\/molecules20059183","volume":"20","author":"Y He","year":"2015","unstructured":"He Y, Yue Y, Zheng X, Zhang K, Chen S, Du Z (2015) Curcumin, inflammation, and chronic diseases: how are they linked? Molecules 20:9183\u20139213","journal-title":"Molecules"},{"key":"4914_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102051","author":"MZ Hossain","year":"2017","unstructured":"Hossain MZ, Unno S, Ando H, Masuda Y, Kitagawa J (2017) Neuron-glia crosstalk and neuropathic pain: involvement in the modulation of motor activity in the orofacial region. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms18102051","journal-title":"Int J Mol Sci"},{"key":"4914_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e37350","volume":"10","author":"N Hu","year":"2024","unstructured":"Hu N, Liu J, Luo Y, Li Y (2024) A comprehensive review of traditional Chinese medicine in treating neuropathic pain. Heliyon 10:e37350","journal-title":"Heliyon"},{"key":"4914_CR15","doi-asserted-by":"publisher","first-page":"e32693","DOI":"10.1097\/MD.0000000000032693","volume":"102","author":"X Jiang","year":"2023","unstructured":"Jiang X, Zhou J, Yu Z, Gu X, Lu Y, Ruan Y, Wang T (2023) Exploration of Fuzheng Yugan mixture on COVID-19 based on network pharmacology and molecular docking. Medicine (Baltimore) 102:e32693","journal-title":"Medicine (Baltimore)"},{"key":"4914_CR16","doi-asserted-by":"crossref","unstructured":"Kamal D, Salamt N, Yusuf A, Kashim M, Mokhtar MH (2021) Potential Health Benefits of Curcumin on Female Reproductive Disorders: A Review. Nutrients, 13","DOI":"10.3390\/nu13093126"},{"key":"4914_CR17","doi-asserted-by":"publisher","first-page":"4497","DOI":"10.1002\/jcp.26249","volume":"233","author":"F Keihanian","year":"2018","unstructured":"Keihanian F, Saeidinia A, Bagheri RK, Johnston TP, Sahebkar A (2018) Curcumin, hemostasis, thrombosis, and coagulation. J Cell Physiol 233:4497\u20134511","journal-title":"J Cell Physiol"},{"key":"4914_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15102093","author":"Y Kim","year":"2018","unstructured":"Kim Y, Clifton P (2018) Curcumin, cardiometabolic health and dementia. Int J Environ Res Public Health. https:\/\/doi.org\/10.3390\/ijerph15102093","journal-title":"Int J Environ Res Public Health"},{"key":"4914_CR19","doi-asserted-by":"publisher","DOI":"10.1177\/1744806920936502","volume":"16","author":"KM Kober","year":"2020","unstructured":"Kober KM, Lee MC, Olshen A, Conley YP, Sirota M, Keiser M, Hammer MJ, Abrams G, Schumacher M, Levine JD, Miaskowski C (2020) Differential methylation and expression of genes in the hypoxia-inducible factor 1 signaling pathway are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors and with preclinical models of chemotherapy-induced neuropathic pain. Mol Pain 16:1744806920936502","journal-title":"Mol Pain"},{"key":"4914_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2023.114576","volume":"370","author":"JY Lee","year":"2023","unstructured":"Lee JY, Park CS, Seo KJ, Kim IY, Han S, Youn I, Yune TY (2023) IL-6\/JAK2\/STAT3 axis mediates neuropathic pain by regulating astrocyte and microglia activation after spinal cord injury. Exp Neurol 370:114576","journal-title":"Exp Neurol"},{"key":"4914_CR21","doi-asserted-by":"publisher","first-page":"489","DOI":"10.4062\/biomolther.2016.006","volume":"24","author":"D Li","year":"2016","unstructured":"Li D, Yan Y, Yu L, Duan Y (2016) Procaine attenuates pain behaviors of neuropathic pain model rats possibly via inhibiting JAK2\/STAT3. Biomol Ther Seoul 24:489\u2013494","journal-title":"Biomol Ther Seoul"},{"key":"4914_CR22","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6833867","volume":"2022","author":"D Lin","year":"2022","unstructured":"Lin D, Zhang M, Luo C, Wei P, Cui K, Chen Z (2022) Targeting ferroptosis attenuates inflammation, fibrosis, and mast cell activation in chronic prostatitis. J Immunol Res 2022:6833867","journal-title":"J Immunol Res"},{"key":"4914_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28041623","author":"Z Liu","year":"2023","unstructured":"Liu Z, Ma H, Lai Z (2023) The role of ferroptosis and cuproptosis in curcumin against hepatocellular carcinoma. Molecules. https:\/\/doi.org\/10.3390\/molecules28041623","journal-title":"Molecules"},{"key":"4914_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2022.103437","volume":"28","author":"KH Lu","year":"2023","unstructured":"Lu KH, Lu PW, Lin CW, Yang SF (2023) Curcumin in human osteosarcoma: from analogs to carriers. Drug Discov Today 28:103437","journal-title":"Drug Discov Today"},{"key":"4914_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e21249","volume":"9","author":"P Mamsharifi","year":"2023","unstructured":"Mamsharifi P, Farokhi B, Hajipoor-Taziani R, Alemi F, Hazegh P, Masoumzadeh S, Jafari L, Ghaderi A, Ghadami DS (2023) Nano-curcumin effects on nicotine dependence, depression, anxiety and metabolic parameters in smokers: a randomized double-blind clinical study. Heliyon 9:e21249","journal-title":"Heliyon"},{"key":"4914_CR26","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1007\/s40122-024-00659-6","volume":"13","author":"Z Mao","year":"2024","unstructured":"Mao Z, Lv J, Sun Y, Shen J, Gao Y, Sun S, Yang D (2024) Peripheral nerve stimulation for neuropathic pain management: a narrative review. Pain Ther 13:1387\u20131406","journal-title":"Pain Ther"},{"key":"4914_CR27","doi-asserted-by":"publisher","first-page":"575","DOI":"10.2174\/1871520620666200918113625","volume":"21","author":"H Mirzaei","year":"2021","unstructured":"Mirzaei H, Bagheri H, Ghasemi F, Khoi JM, Pourhanifeh MH, Heyden YV, Mortezapour E, Nikdasti A, Jeandet P, Khan H, Sahebkar A (2021) Anti-cancer activity of curcumin on multiple myeloma. Anticancer Agents Med Chem 21:575\u2013586","journal-title":"Anticancer Agents Med Chem"},{"key":"4914_CR28","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.2174\/1381612824666180522105202","volume":"24","author":"AA Momtazi-Borojeni","year":"2018","unstructured":"Momtazi-Borojeni AA, Ghasemi F, Hesari A, Majeed M, Caraglia M, Sahebkar A (2018) Anti-cancer and radio-sensitizing effects of curcumin in nasopharyngeal carcinoma. Curr Pharm des 24:2121\u20132128","journal-title":"Curr Pharm des"},{"key":"4914_CR29","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1080\/10408398.2018.1552244","volume":"60","author":"SS Patel","year":"2020","unstructured":"Patel SS, Acharya A, Ray RS, Agrawal R, Raghuwanshi R, Jain P (2020) Cellular and molecular mechanisms of curcumin in prevention and treatment of disease. Crit Rev Food Sci Nutr 60:887\u2013939","journal-title":"Crit Rev Food Sci Nutr"},{"key":"4914_CR30","doi-asserted-by":"publisher","first-page":"D877","DOI":"10.1093\/nar\/gkw1012","volume":"45","author":"N Rappaport","year":"2017","unstructured":"Rappaport N, Twik M, Plaschkes I, Nudel R, Iny ST, Levitt J, Gershoni M, Morrey CP, Safran M, Lancet D (2017) Malacards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search. Nucleic Acids Res 45:D877\u2013D887","journal-title":"Nucleic Acids Res"},{"key":"4914_CR31","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/bs.irn.2024.10.012","volume":"179","author":"J Rosner","year":"2024","unstructured":"Rosner J, Attal N, Finnerup NB (2024) Clinical pharmacology of neuropathic pain. Int Rev Neurobiol 179:403\u2013430","journal-title":"Int Rev Neurobiol"},{"key":"4914_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2023.102363","volume":"134","author":"S Shao","year":"2023","unstructured":"Shao S, Ye X, Su W, Wang Y (2023) Curcumin alleviates Alzheimer\u2019s disease by inhibiting inflammatory response, oxidative stress and activating the AMPK pathway. J Chem Neuroanat 134:102363","journal-title":"J Chem Neuroanat"},{"key":"4914_CR33","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1021\/acs.jcim.5b00559","volume":"55","author":"T Sterling","year":"2015","unstructured":"Sterling T, Irwin JJ (2015) ZINC 15\u2013ligand discovery for everyone. J Chem Inf Model 55:2324\u20132337","journal-title":"J Chem Inf Model"},{"key":"4914_CR34","doi-asserted-by":"publisher","first-page":"9459","DOI":"10.1007\/s12035-024-04133-4","volume":"61","author":"J Tang","year":"2024","unstructured":"Tang J, Chen Q, Xiang L, Tu T, Zhang Y, Ou C (2024) TRIM28 Fosters Microglia Ferroptosis via Autophagy Modulation to Enhance Neuropathic Pain and Neuroinflammation. Mol Neurobiol 61:9459\u20139477","journal-title":"Mol Neurobiol"},{"key":"4914_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20051033","author":"MA Tomeh","year":"2019","unstructured":"Tomeh MA, Hadianamrei R, Zhao X (2019) A review of curcumin and its derivatives as anticancer agents. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms20051033","journal-title":"Int J Mol Sci"},{"key":"4914_CR36","first-page":"1050","volume":"21","author":"A Unlu","year":"2016","unstructured":"Unlu A, Nayir E, Dogukan KM, Kirca O, Ozdogan M (2016) Curcumin (turmeric) and cancer. J BUON 21:1050\u20131060","journal-title":"J BUON"},{"issue":"W1","key":"4914_CR37","doi-asserted-by":"publisher","first-page":"W356","DOI":"10.1093\/nar\/gkx374","volume":"45","author":"X Wang","year":"2017","unstructured":"Wang X, Shen Y, Wang S, Li S, Zhang W, Liu X, Lai L, Pei J, Li H (2017) Pharmmapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database. Nucleic Acids Res 45(W1):W356\u2013W360","journal-title":"Nucleic Acids Res"},{"key":"4914_CR38","doi-asserted-by":"publisher","first-page":"e29593","DOI":"10.1097\/MD.0000000000029593","volume":"101","author":"T Wang","year":"2022","unstructured":"Wang T, Jiang X, Ruan Y, Li L, Chu L (2022) The mechanism of action of the combination of Astragalus membranaceus and Ligusticum chuanxiong in the treatment of ischemic stroke based on network pharmacology and molecular docking. Medicine (Baltimore) 101:e29593","journal-title":"Medicine (Baltimore)"},{"key":"4914_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-41101-9","volume":"13","author":"T Wang","year":"2023","unstructured":"Wang T, Yin Y, Jiang X, Ruan Y, Xu J, Hu X, Li T, Chu L, Li L (2023) Exploring the mechanism of luteolin by regulating microglia polarization based on network pharmacology and in vitro experiments. Sci Rep 13:13767","journal-title":"Sci Rep"},{"key":"4914_CR40","doi-asserted-by":"publisher","first-page":"e37153","DOI":"10.1097\/MD.0000000000037153","volume":"103","author":"X Wang","year":"2024","unstructured":"Wang X, Wang T, Jiang X, Ruan Y, Wang J, Qi C (2024) The potential mechanism of Guizhi Fuling Wan effect in the treatment of cervical squamous cell carcinoma: a bioinformatics analysis investigation. Med (Baltimore) 103:e37153","journal-title":"Med (Baltimore)"},{"key":"4914_CR41","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1411-x","volume":"16","author":"HC Xiang","year":"2019","unstructured":"Xiang HC, Lin LX, Hu XF, Zhu H, Li HP, Zhang RY, Hu L, Liu WT, Zhao YL, Shu Y, Pan HL, Li M (2019) AMPK activation attenuates inflammatory pain through inhibiting NF-kappaB activation and IL-1beta expression. J Neuroinflammation 16:34","journal-title":"J Neuroinflammation"},{"key":"4914_CR42","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.lfs.2017.09.033","volume":"190","author":"YY Yan","year":"2017","unstructured":"Yan YY, Li CY, Zhou L, Ao LY, Fang WR, Li YM (2017) Research progress of mechanisms and drug therapy for neuropathic pain. Life Sci 190:68\u201377","journal-title":"Life Sci"},{"key":"4914_CR43","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-1731-x","volume":"17","author":"H Yang","year":"2020","unstructured":"Yang H, Wu L, Deng H, Chen Y, Zhou H, Liu M, Wang S, Zheng L, Zhu L, Lv X (2020) Anti-inflammatory protein TSG-6 secreted by bone marrow mesenchymal stem cells attenuates neuropathic pain by inhibiting the TLR2\/MyD88\/NF-kappaB signaling pathway in spinal microglia. J Neuroinflammation 17:154","journal-title":"J Neuroinflammation"},{"key":"4914_CR44","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2240894","volume":"2022","author":"H Yu","year":"2022","unstructured":"Yu H, Zhang Z, Wei F, Hou G, You Y, Wang X, Cao S, Yang X, Liu W, Zhang S, Hu F, Zhang X (2022) Hydroxytyrosol ameliorates intervertebral disc degeneration and neuropathic pain by reducing oxidative stress and inflammation. Oxid Med Cell Longev 2022:2240894","journal-title":"Oxid Med Cell Longev"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04914-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04914-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04914-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T02:40:59Z","timestamp":1778121659000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04914-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,21]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["4914"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04914-1","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,21]]},"assertion":[{"value":"27 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}