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Since benzohydrazides are known as MPO inhibitors, a series of six\n                    <jats:italic>N<\/jats:italic>\n                    '-phenylbenzohydrazides and one quinazolin-4(3\n                    <jats:italic>H<\/jats:italic>\n                    )-one analogue was evaluated through in vitro assays to measure inhibition of MPO, superoxide dismutase (SOD), and catalase (CAT) activities, as well as DPPH and superoxide-scavenging effects. Pharmacokinetic parameters of the compounds were evaluated in silico\n                    <jats:italic>,<\/jats:italic>\n                    and molecular docking studies were performed to predict their binding modes with the catalytic site of MPO. All phenylbenzohydrazides exhibited potent inhibitory effect on MPO activity, with four of them presenting IC\n                    <jats:sub>50<\/jats:sub>\n                    values below 0.5\u00a0\u03bcM. Bromine substitution, as in\n                    <jats:bold>2b<\/jats:bold>\n                    ,\n                    <jats:bold>2e<\/jats:bold>\n                    , and\n                    <jats:bold>2f<\/jats:bold>\n                    , enhanced the binding affinity to the active site of MPO, resulting in high inhibitory potency. In concentrations as high as 50\u00a0\u03bcM, compounds did not inhibit SOD activity but showed some inhibitory activity over CAT. Except for compound\n                    <jats:bold>2c<\/jats:bold>\n                    , the phenylbenzohydrazides can scavenge DPPH radical, while only\n                    <jats:bold>2e<\/jats:bold>\n                    can sequester superoxide anion. Quinazolin-4(3\n                    <jats:italic>H<\/jats:italic>\n                    )-one analogue\n                    <jats:bold>3<\/jats:bold>\n                    , obtained from phenylbenzohydrazide\n                    <jats:bold>2a<\/jats:bold>\n                    showed a more selective profile towards MPO compared to CAT but antioxidant activity was not observed. Phenylbenzohydrazide\n                    <jats:bold>2e<\/jats:bold>\n                    is a potent MPO inhibitor with antioxidant properties, demonstrated through DPPH and superoxide anion scavenging, with high predicted gastrointestinal absorption. The results obtained in this study with\n                    <jats:italic>N<\/jats:italic>\n                    \u2019-phenylbenzohydrazides highlight the importance of structural modifications to improve the pharmacological profile of phenylhydrazides, contributing to the development of new anti-inflammatory drugs.\n                  <\/jats:p>","DOI":"10.1007\/s00210-025-04926-x","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T02:57:39Z","timestamp":1769655459000},"page":"10087-10096","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of phenyl hydrazide-based compounds as myeloperoxidase inhibitors"],"prefix":"10.1007","volume":"399","author":[{"given":"Laryssa C. C. 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