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The swelling behavior of the cryogels was evaluated, and their biocompatibility was assessed against L929 fibroblast cells. The antibacterial efficacy of the cryogel membranes against multidrug-resistant (MDR)\n                    <jats:italic>Escherichia coli (E. coli) and methicillin-resistant<\/jats:italic>\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA) was investigated using disk diffusion and time\u2013kill assays, while bacteria-induced morphological alterations were visualized by SEM. Molecular docking studies were performed to elucidate the interaction mechanisms of morin with 4DUH, 4DX5, 4WUB, and 5NC5 proteins, yielding docking scores of\u2009\u2212\u20095.578,\u2009\u2212\u20094.142,\u2009\u2212\u20096.955, and\u2009\u2212\u20094.607\u00a0kcal\/mol, respectively. The strongest binding affinity was observed for 4WUB, supported by the lowest docking score and a Glide emodel value of\u2009\u2212\u200958.834, indicating a stable ligand\u2013protein complex. The synthesized cryogels exhibited a high swelling ratio of 97.89\u2009\u00b1\u200914.21% and demonstrated excellent biocompatibility, with L929 cell viability ranging from 86 to 100% after 48\u00a0h of exposure, even at the highest tested dose of 1.5\u00a0mg, confirming the absence of cytotoxic effects. The MM1 and MM2 cryogel membranes showed pronounced antibacterial activity against MDR\n                    <jats:italic>E. coli,<\/jats:italic>\n                    producing inhibition zones of 16.1\u00a0mm and 17.6\u00a0mm, respectively. In time\u2013kill assays, MM1 exhibited inhibition rates of 48.3% against MRSA and 91.6% against MDR\n                    <jats:italic>E. coli<\/jats:italic>\n                    at the 8th hour, while MM2 achieved enhanced inhibition rates of 57.1% and 99.6%, respectively. Overall, these findings indicate that morin-loaded pHEMA cryogel membranes represent promising antibacterial platforms for the treatment of infected wounds and for medical device surface coatings to prevent bacterial colonization and infection.\n                  <\/jats:p>","DOI":"10.1007\/s00210-026-04976-9","type":"journal-article","created":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T11:17:07Z","timestamp":1768130227000},"page":"8709-8720","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Morin-functionalized pHEMA cryogel membranes for combating MDR Escherichia coli and MRSA: antibacterial efficacy and molecular docking study"],"prefix":"10.1007","volume":"399","author":[{"given":"\u00d6zge \u00d6zt\u00fcrk","family":"Cimentepe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet\u00a0","family":"Cimentepe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kemal","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin\u00a0","family":"Yildirim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,11]]},"reference":[{"key":"4976_CR1","doi-asserted-by":"publisher","DOI":"10.2147\/idr.s428103","author":"AA Abebe","year":"2023","unstructured":"Abebe AA, Birhanu AG (2023) Methicillin resistant Staphylococcus aureus: molecular mechanisms underlying drug resistance development and novel strategies to combat. 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