{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:28:55Z","timestamp":1789010935424,"version":"build-2803163510"},"reference-count":90,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s00210-026-05021-5","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T05:43:09Z","timestamp":1769060589000},"page":"9627-9654","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Global evolution of ferroptosis research: a comprehensive bibliometric analysis of publication trends, geographic patterns, pharmacological innovation, and translational progress from inception through 2025"],"prefix":"10.1007","volume":"399","author":[{"given":"Manal Mohamed Elhassan","family":"Taha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddig Ibrahim","family":"Abdelwahab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"5021_CR1","doi-asserted-by":"publisher","first-page":"15287","DOI":"10.1007\/s00210-025-04143-6","volume":"398","author":"M Aabis","year":"2025","unstructured":"Aabis M, Tiwari P, Kumar V, Singh G, Panghal A, Jena G (2025) Pentadecanoic acid attenuates thioacetamide-induced liver fibrosis by modulating oxidative stress, inflammation, and ferroptosis pathways in rat. Naunyn Schmiedebergs Arch Pharmacol 398:15287\u201315306","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"5021_CR2","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.reth.2024.02.007","volume":"27","author":"J Aalders","year":"2024","unstructured":"Aalders J, L\u00e9ger L, Hassannia B, Goossens V, Vanden Berghe T, van Hengel J (2024) Improving cardiac differentiation of human pluripotent stem cells by targeting ferroptosis. Regen Ther 27:21\u201331","journal-title":"Regen Ther"},{"issue":"12","key":"5021_CR3","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.3390\/antiox13121440","volume":"13","author":"X Abadin","year":"2024","unstructured":"Abadin X, de Dios C, Zubillaga M, Ivars E, Puigr\u00f2s M, Mar\u00ed M, Morales A, Vizuete M, Vitorica J, Trullas R, Colell A, Roca-Agujetas V (2024) Neuroinflammation in age-related neurodegenerative diseases: role of mitochondrial oxidative stress. Antioxidants (Basel) 13(12):1440","journal-title":"Antioxidants (Basel)"},{"key":"5021_CR4","doi-asserted-by":"crossref","unstructured":"Abah MO, Ogenyi DO, Zhilenkova AV, Essogmo FE, Uchendu IK, Tchawe YSN, Pascal AM, Nikitina NM, Oloche OS, Pavliv M, Rusanov AS, Sanikovich VD, Pirogova YN, Bagmet LN, Moiseeva AV, Sekacheva MI (2025) Comparative transcriptomics study of curcumin and conventional therapies in translocation, clear cell, and papillary renal cell carcinoma subtypes. Int J Mol Sci 26(13):6161","DOI":"10.3390\/ijms26136161"},{"key":"5021_CR5","doi-asserted-by":"publisher","unstructured":"Abass SA, Mohamed AA, El-Slam AHA, Yousef AM, Ayoub MK, Salah B, Abdo W, Hamid MMA (2025) Vitamin K1 attenuates acetaminophen-induced ferroptotic hepatic damage in mice via targeting keap1\/Nrf2\/HO-1 pathway. Naunyn Schmiedebergs Arch Pharmacol.  https:\/\/doi.org\/10.1007\/s00210-025-04637-3","DOI":"10.1007\/s00210-025-04637-3"},{"key":"5021_CR6","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1007\/s11064-025-04438-3","volume":"50","author":"SR Abd El-Khalik","year":"2025","unstructured":"Abd El-Khalik SR, AbuoHashish NA, Nasif E, Arakeep HM, El-Anwar N, Yousef DM, Ayad NH (2025) Possible mitigating effect of nobiletin on rotenone-induced parkinsonism in male albino rat model: targeting Bmal1\/Nrf2 mediated ferroptosis and restoring mitochondrial mitophagy. Neurochem Res 50:208","journal-title":"Neurochem Res"},{"key":"5021_CR7","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.joi.2017.08.007","volume":"11","author":"M Aria","year":"2017","unstructured":"Aria M, Cuccurullo C (2017) Bibliometrix: an R-tool for comprehensive science mapping analysis. J Informetr 11:959\u2013975","journal-title":"J Informetr"},{"issue":"6486","key":"5021_CR8","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1126\/science.aaw9872","volume":"368","author":"MA Badgley","year":"2020","unstructured":"Badgley MA, Kremer DM, Carlo Maurer H, DelGiorno KE, Lee HJ, Purohit V, Sagalovskiy IR, Ma A, Kapilian J, Firl CEM, Decker AR, Sastra SA, Palermo CF, Andrade LR, Sajjakulnukit P, Zhang L, Tolstyka ZP, Hirschhorn T, Lamb C, Liu T, Gu W, Scott Seeley E, Stone E, Georgiou G, Manor U, Iuga A, Wahl GM, Stockwell BR, Lyssiotis CA, Olive KP (2020) Cysteine depletion induces pancreatic tumor ferroptosis in mice. Science 368(6486):85\u201389","journal-title":"Science"},{"key":"5021_CR9","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","volume":"575","author":"K Bersuker","year":"2019","unstructured":"Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R, Bassik MC, Nomura DK, Dixon SJ, Olzmann JA (2019) The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature 575:688\u2013692","journal-title":"Nature"},{"key":"5021_CR10","doi-asserted-by":"publisher","first-page":"1625928","DOI":"10.3389\/fcimb.2025.1625928","volume":"15","author":"C Cevallos","year":"2025","unstructured":"Cevallos C, Jarmoluk P, Sviercz F, Freiberger RN, L\u00f3pez CAM, Delpino MV, Quarleri J (2025) Ferroptosis and mitochondrial ROS are central to SARS-CoV-2-induced hepatocyte death. Front Cell Infection Microbiology 15:1625928","journal-title":"Front Cell Infection Microbiology"},{"key":"5021_CR11","doi-asserted-by":"crossref","unstructured":"Chang Y, Sun Z, Xu M (2025) miR-4793\u20133p predicts poor prognosis and regulates ferroptosis and invasiveness of breast cancer via targeting RNF169. World J Surg Oncol 23(1):381","DOI":"10.1186\/s12957-025-04036-1"},{"key":"5021_CR12","first-page":"1","volume":"1","author":"C Chen","year":"2014","unstructured":"Chen C (2014) The citespace manual. College of Computing and Informatics 1:1\u201384","journal-title":"College of Computing and Informatics"},{"key":"5021_CR13","doi-asserted-by":"publisher","first-page":"580","DOI":"10.4163\/jnh.2024.57.6.580","volume":"57","author":"JY Choi","year":"2024","unstructured":"Choi JY, Chung J (2024) Hepatoprotective effects of an iron chelator, deferoxamine, in a mouse model of metabolic dysfunction-associated fatty liver disease. J Nutr Health 57:580\u2013589","journal-title":"J Nutr Health"},{"key":"5021_CR14","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/s41556-019-0305-6","volume":"21","author":"B Chu","year":"2019","unstructured":"Chu B, Kon N, Chen D, Li T, Liu T, Jiang L, Song S, Tavana O, Gu W (2019) ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway. Nat Cell Biol 21:579\u2013591","journal-title":"Nat Cell Biol"},{"key":"5021_CR15","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/1440-1681.13732","volume":"50","author":"H Deng","year":"2023","unstructured":"Deng H, Wei J, Min K, Yang H, Wang S, Xiao Z, Liu M, Zheng L, Zhou H, Chen Y, Zhu W, Li Q, Lv X (2023) Research trends in ferroptosis since the origin of the concept: a bibliometric analysis. Clin Exp Pharmacol Physiol 50:149\u2013157","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"5021_CR16","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149:1060\u20131072","journal-title":"Cell"},{"key":"5021_CR17","doi-asserted-by":"publisher","unstructured":"Dixon SJ, Patel D, Welsch M, Skouta R, Lee E, Hayano M, Thomas AG, Gleason C, Tatonetti N, Slusher BS, Stockwell BR (2014) Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. eLife 2014.\u00a020(3):e02523. https:\/\/doi.org\/10.7554\/eLife.02523","DOI":"10.7554\/eLife.02523"},{"key":"5021_CR18","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nchembio.2239","volume":"13","author":"S Doll","year":"2017","unstructured":"Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A, Prokisch H, Tr\u00fcmbach D, Mao G, Qu F, Bay\u00edr H, F\u00fcllekrug J, Scheel CH, Wurst W, Schick JA, Kagan VE, Friedmann-Angeli JPF, Conrad M (2017) ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol 13:91\u201398","journal-title":"Nat Chem Biol"},{"key":"5021_CR19","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","volume":"575","author":"S Doll","year":"2019","unstructured":"Doll S, Freitas FP, Shah R, Aldrovandi M, da Costa Silva MC, Ingold I, Grocin AG, da Xavier Silva TN, Panzilius E, Scheel CH, Mour\u00e3o A, Buday K, Sato M, Wanninger J, Vignane T, Mohana V, Rehberg M, Flatley A, Schepers A, Kurz A, White D, Sauer M, Sattler M, Tate EW, Schmitz W, Schulze A, O\u2019Donnell V, Proneth B, Popowicz GM, Pratt DA, Friedmann-Angeli JPF, Conrad M (2019) FSP1 is a glutathione-independent ferroptosis suppressor. Nature 575:693\u2013698","journal-title":"Nature"},{"issue":"1","key":"5021_CR20","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s10238-025-01880-z","volume":"25","author":"L Du","year":"2025","unstructured":"Du L, Lv S, He D, Chen X, Liu L, Song X, Zhang J, Qiao Z, Luo Y (2025) The ferroptosis-related gene MAFG screened by machine learning is associated with the diagnosis and prognosis of sepsis. Clinical and Experimental Medicine 25(1):347","journal-title":"Clinical and Experimental Medicine"},{"issue":"8","key":"5021_CR21","doi-asserted-by":"publisher","first-page":"e37","DOI":"10.1038\/oncsis.2017.65","volume":"6","author":"Z Fan","year":"2017","unstructured":"Fan Z, Wirth AK, Chen D, Wruck CJ, Rauh M, Buchfelder M, Savaskan N (2017) Nrf2-keap1 pathway promotes cell proliferation and diminishes ferroptosis. Oncogenesis 6(8):e37","journal-title":"Oncogenesis"},{"key":"5021_CR22","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1161\/CIRCRESAHA.120.316509","volume":"127","author":"X Fang","year":"2020","unstructured":"Fang X, Cai Z, Wang H, Han D, Cheng Q, Zhang P, Gao F, Yu Y, Song Z, Wu Q, An P, Huang S, Pan J, Chen HZ, Chen J, Linkermann A, Min J, Wang F (2020) Loss of cardiac ferritin H facilitates cardiomyopathy via Slc7a11-mediated ferroptosis. Circ Res 127:486\u2013501","journal-title":"Circ Res"},{"issue":"1","key":"5021_CR23","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1007\/s12672-025-02283-y","volume":"16","author":"B Feng","year":"2025","unstructured":"Feng B, Guo HY, Ning Y, Zhao YY, Wang X, Cui R (2025) LPCAT3 regulates the immune infiltration and prognosis of ccRCC patients by mediating ferroptosis and endoplasmic reticulum stress. Discover Oncology 16(1):574","journal-title":"Discover Oncology"},{"key":"5021_CR24","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/ncb3064","volume":"16","author":"JPF Friedmann-Angeli","year":"2014","unstructured":"Friedmann-Angeli JPF, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, R\u00e5dmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, F\u00f6rster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR, O\u2019Donnell VB, Kagan VE, Schick JA, Conrad M (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol 16:1180\u20131191","journal-title":"Nat Cell Biol"},{"key":"5021_CR25","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","volume":"59","author":"M Gao","year":"2015","unstructured":"Gao M, Monian P, Quadri N, Ramasamy R, Jiang X (2015) Glutaminolysis and transferrin regulate ferroptosis. Mol Cell 59:298\u2013308","journal-title":"Mol Cell"},{"key":"5021_CR26","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/s41589-018-0031-6","volume":"14","author":"MM Gaschler","year":"2018","unstructured":"Gaschler MM, Andia AA, Liu H, Csuka JM, Hurlocker B, Vaiana CA, Heindel DW, Zuckerman DS, Bos PH, Reznik E, Ye LF, Tyurina YY, Lin AJ, Shchepinov MS, Chan AY, Peguero-Pereira E, Fomich MA, Daniels JD, Bekish AV, Shmanai VV, Kagan VE, Mahal LK, Woerpel KA, Stockwell BR (2018) FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol 14:507\u2013515","journal-title":"Nat Chem Biol"},{"key":"5021_CR27","doi-asserted-by":"publisher","first-page":"445","DOI":"10.4143\/crt.2016.572","volume":"50","author":"J Guo","year":"2018","unstructured":"Guo J, Xu B, Han Q, Zhou H, Xia Y, Gong C, Dai X, Li Z, Wu G (2018) Ferroptosis: a novel anti-tumor action for cisplatin. Cancer Res Treat 50:445\u2013460","journal-title":"Cancer Res Treat"},{"key":"5021_CR28","doi-asserted-by":"publisher","unstructured":"Guo SB, Liu DY, Fang XJ, Meng Y, Zhou ZZ, Li J, Li M, Luo LL, Li HL, Cai XY, Huang WJ, Tian XP (9900) Current concerns and future directions of large language model chatGPT in medicine: a machine-learning-driven global-scale bibliometric analysis. Int J Surg. https:\/\/doi.org\/10.1097\/JS1099.0000000000003668","DOI":"10.1097\/JS1099.0000000000003668"},{"key":"5021_CR29","doi-asserted-by":"crossref","unstructured":"Guo SB, Liu DY, Hu R, Zhou ZZ, Meng Y, Li HL, Huang WJ, Tian XP (2025) Immune-related adverse events of neoadjuvant immunotherapy in patients with perioperative cancer: a machine-learning-driven, decade-long informatics investigation. J Immunother Cancer 13(8):e011040","DOI":"10.1136\/jitc-2024-011040"},{"key":"5021_CR30","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1002\/mc.70045","volume":"64","author":"T Huang","year":"2025","unstructured":"Huang T, Zhang J (2025) Therapeutic suppression of triple-negative breast cancer via pachymic acid-induced KIF18B inhibition and ferroptosis activation. Mol Carcinog 64:2075\u20132085","journal-title":"Mol Carcinog"},{"key":"5021_CR31","doi-asserted-by":"publisher","unstructured":"Jankauskas SS, Kansakar U, Sardu C, Varzideh F, Avvisato R, Wang X, Matarese A, Marfella R, Ziosi M, Gambardella J, Santulli G (2023) COVID-19 causes ferroptosis and oxidative stress in human endothelial cells. Antioxidants (Basel) 12. https:\/\/doi.org\/10.3390\/antiox12020326","DOI":"10.3390\/antiox12020326"},{"key":"5021_CR32","doi-asserted-by":"publisher","first-page":"e18950","DOI":"10.1016\/j.heliyon.2023.e18950","volume":"9","author":"B Ji","year":"2023","unstructured":"Ji B, Yang G, Jin H, Liu X, Li H, Pan L, Lu W, Zhu H, Li Y (2023) Trends and hotspots of publications on ferroptosis: a 10 year overview. Heliyon 9:e18950","journal-title":"Heliyon"},{"key":"5021_CR33","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nature14344","volume":"520","author":"L Jiang","year":"2015","unstructured":"Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H, Baer R, Gu W (2015) Ferroptosis as a p53-mediated activity during tumour suppression. Nature 520:57\u201362","journal-title":"Nature"},{"key":"5021_CR34","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nchembio.2238","volume":"13","author":"VE Kagan","year":"2017","unstructured":"Kagan VE, Mao G, Qu F, Friedmann-Angeli JPF, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M, Bay\u00edr H (2017) Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol 13:81\u201390","journal-title":"Nat Chem Biol"},{"key":"5021_CR35","doi-asserted-by":"publisher","first-page":"841724","DOI":"10.3389\/fcell.2022.841724","volume":"10","author":"G Li","year":"2022","unstructured":"Li G, Liang Y, Yang H, Zhang W, Xie T (2022) The research landscape of ferroptosis in cancer: a bibliometric analysis. Frontiers in Cell and Developmental Biology 10:841724","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"5021_CR36","doi-asserted-by":"crossref","unstructured":"Li J, Wang Y, Huang J, Gong D (2024a) Knowledge mapping of ferroptosis in Parkinson\u2019s disease: a bibliometric analysis: 2012\u20132023. Front Aging Neurosci 16:1433325","DOI":"10.3389\/fnagi.2024.1433325"},{"key":"5021_CR37","doi-asserted-by":"publisher","first-page":"1407924","DOI":"10.3389\/fimmu.2024.1407924","volume":"15","author":"Y Li","year":"2024","unstructured":"Li Y, Tang L, Wang F, Gao C, Yang Q, Luo L, Wei J, Tang Q, Qi M (2024) Hub genes identification and validation of ferroptosis in SARS-CoV-2 induced ARDS: perspective from transcriptome analysis. Front Immunol 15:1407924","journal-title":"Front Immunol"},{"issue":"1","key":"5021_CR38","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1007\/s12672-025-02333-5","volume":"16","author":"SP Lin","year":"2025","unstructured":"Lin SP, Huang FY, Wu RH, Xie WJ, Chen MH, Dai SZ, Xu WT, Zheng WP, Tan GH (2025) Toxicarioside H induces ferroptosis in triple-negative breast cancer cells through Nrf2\/HO-1 pathway. Discover Oncology 16(1):772","journal-title":"Discover Oncology"},{"key":"5021_CR39","doi-asserted-by":"crossref","unstructured":"Lin X, Yang H, Cai T, Yang Z, Niu S, Jia H (2025b) Polygonum multiflorum stilbene glycoside oligomers induce the ferroptosis of triple negative breast cancer cells. BMC Cancer 25(1):676","DOI":"10.1186\/s12885-025-13999-z"},{"key":"5021_CR40","doi-asserted-by":"publisher","first-page":"16836","DOI":"10.1073\/pnas.1415518111","volume":"111","author":"A Linkermann","year":"2014","unstructured":"Linkermann A, Skouta R, Himmerkus N, Mulay SR, Dewitz C, de Zen F, Pr\u00f3kai A, Zuchtriegel G, Krombach F, Welz PS, Weinlich R, Vandenberghe TV, Vandenabeele P, Pasparakis M, Bleich M, Weinberg JM, Reichel CA, Br\u00e4sen JH, Kunzendorf U, Anders HJ, Stockwell BR, Green DR, Krautwald S (2014) Synchronized renal tubular cell death involves ferroptosis. Proc Natl Acad Sci U S A 111:16836\u201316841","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5021_CR41","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-020-00205-0","author":"P Liu","year":"2020","unstructured":"Liu P, Feng Y, Li H, Chen X, Wang G, Xu S, Li Y, Zhao L (2020) Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis. Cell Mol Biol Lett. https:\/\/doi.org\/10.1186\/s11658-020-00205-0","journal-title":"Cell Mol Biol Lett"},{"key":"5021_CR42","doi-asserted-by":"publisher","first-page":"23","DOI":"10.15586\/aei.v53i3.1340","volume":"53","author":"Y Liu","year":"2025","unstructured":"Liu Y, Tang H, Xu P, Zhou X, Li S (2025) SARS-CoV-2 n protein interacts with SLC7A11 to cause ferroptosis in acute lung injury. Allergol Immunopathol (Madr) 53:23\u201330","journal-title":"Allergol Immunopathol (Madr)"},{"key":"5021_CR43","doi-asserted-by":"publisher","first-page":"e66286","DOI":"10.2196\/66286","volume":"14","author":"J-Y Luo","year":"2025","unstructured":"Luo J-Y, Deng Y-L, Lu S-Y, Chen S-Y, He R-Q, Qin D-Y, Chi B-T, Chen G, Yang X, Peng W (2025) Current status and future directions of ferroptosis research in breast cancer: bibliometric analysis. Interact J Med Res 14:e66286","journal-title":"Interact J Med Res"},{"issue":"1","key":"5021_CR44","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1007\/s12672-025-03492-1","volume":"16","author":"X Ma","year":"2025","unstructured":"Ma X, Quan C (2025) Identification of KIF14 as a ferroptosis biomarker for predicting the prognosis and immunotherapy efficacy of bladder cancer. Discover Oncology 16(1):772","journal-title":"Discover Oncology"},{"key":"5021_CR45","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/s41420-023-01421-1","volume":"9","author":"Y-D Miao","year":"2023","unstructured":"Miao Y-D, Quan W, Dong X, Gan J, Ji C-F, Wang J-T, Zhang F (2023) A bibliometric analysis of ferroptosis, necroptosis, pyroptosis, and cuproptosis in cancer from 2012 to 2022. Cell Death Discov 9:129","journal-title":"Cell Death Discov"},{"key":"5021_CR46","doi-asserted-by":"crossref","unstructured":"Miotto G, Rossetto M, Di Paolo ML, Orian L, Venerando R, Roveri A, Vu\u010dkovi\u0107 AM, Bosello-Travain V, Zaccarin M, Zennaro L, Maiorino M, Toppo S, Ursini F, Cozza G (2020) Insight into the mechanism of ferroptosis inhibition by ferrostatin-1. Redox Biol 28:101328","DOI":"10.1016\/j.redox.2019.101328"},{"key":"5021_CR47","doi-asserted-by":"publisher","unstructured":"Mohammadbeygi A, Brujeni GN, Eftekhari Z, Kazerouni NP (2025) Prescription FINO2 and pirfenidone supported in reducing fibrosis in mouse breast tumor tissue by targeting SLC7A11 and HMOX1. Curr Top Med Chem. https:\/\/doi.org\/10.2174\/0115680266353809250526084207","DOI":"10.2174\/0115680266353809250526084207"},{"key":"5021_CR48","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1007\/s11192-016-2171-3","volume":"110","author":"A Najmi","year":"2017","unstructured":"Najmi A, Rashidi TH, Abbasi A, Travis Waller S (2017) Reviewing the transport domain: an evolutionary bibliometrics and network analysis. Scientometrics 110:843\u2013865","journal-title":"Scientometrics"},{"key":"5021_CR49","first-page":"102143","volume":"43","author":"DT Nhung","year":"2025","unstructured":"Nhung DT, Yousif OEA, Kwon B (2025) Sorafenib induces ferroptosis in human renal cell carcinoma cells through CCAT\/enhancer-binding protein homologous protein. Biochem Biophys Rep 43:102143","journal-title":"Biochem Biophys Rep"},{"key":"5021_CR50","doi-asserted-by":"publisher","first-page":"1601962","DOI":"10.3389\/froh.2025.1601962","volume":"6","author":"J Pan","year":"2025","unstructured":"Pan J, Zhang Y, Zhao B, Shao W, Chen X (2025) Current perspectives and trend of ferroptosis in head and neck cancer: a bibliometric analysis. Frontiers in Oral Health 6:1601962","journal-title":"Frontiers in Oral Health"},{"key":"5021_CR51","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1038\/s41418-023-01204-2","volume":"30","author":"C Peleman","year":"2023","unstructured":"Peleman C, Van Coillie S, Ligthart S, Choi SM, De Waele J, Depuydt P, Benoit D, Schaubroeck H, Francque SM, Dams K, Jacobs R, Robert D, Roelandt R, Seurinck R, Saeys Y, Rajapurkar M, Jorens PG, Hoste E, Vanden Berghe T (2023) Ferroptosis and pyroptosis signatures in critical COVID-19 patients. Cell Death Differ 30:2066\u20132077","journal-title":"Cell Death Differ"},{"issue":"1","key":"5021_CR52","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1007\/s12672-025-03335-z","volume":"16","author":"C Peng","year":"2025","unstructured":"Peng C, Yan F, Xu M, Zhao Y, Sun J (2025) WGCNA and single-cell analysis reveal ferroptosis-related gene signatures for hepatocellular carcinoma prognosis and therapy. Discover Oncology 16(1):1483","journal-title":"Discover Oncology"},{"key":"5021_CR53","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1007\/s12672-025-02234-7","volume":"16","author":"W Song","year":"2025","unstructured":"Song W, Sun P, Zhao T, Zang Y, Dong P, Tang Q, Chen W, Chen W, Wang Z, Zhang Q, Wang Y, Yin C, Yu M (2025) Unveiling the therapeutic potential of ferroptosis in lung cancer: a comprehensive bibliometric analysis and future therapeutic insights. Discov Oncol 16:508","journal-title":"Discov Oncol"},{"key":"5021_CR54","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1016\/j.cub.2018.05.094","volume":"28","author":"X Song","year":"2018","unstructured":"Song X, Zhu S, Chen P, Hou W, Wen Q, Liu J, Xie Y, Liu J, Klionsky DJ, Kroemer G, Lotze MT, Zeh HJ, Kang R, Tang D (2018) AMPK-mediated BECN1 phosphorylation promotes ferroptosis by directly blocking system Xc \u2013 activity. Curr Biol 28:2388-2399.e2385","journal-title":"Curr Biol"},{"key":"5021_CR55","doi-asserted-by":"crossref","unstructured":"Sui X, Zhang R, Liu S, Duan T, Zhai L, Zhang M, Han X, Xiang Y, Huang X, Lin H, Xie T (2018) RSL3 drives ferroptosis through GPX4 inactivation and ros production in colorectal cancer. Front Pharmacol 9:1371","DOI":"10.3389\/fphar.2018.01371"},{"key":"5021_CR56","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1002\/hep.28251","volume":"63","author":"X Sun","year":"2016","unstructured":"Sun X, Ou Z, Chen R, Niu X, Chen D, Kang R, Tang D (2016) Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells. Hepatology 63:173\u2013184","journal-title":"Hepatology"},{"key":"5021_CR57","doi-asserted-by":"publisher","DOI":"10.1186\/s41065-025-00413-8","author":"L Tan","year":"2025","unstructured":"Tan L, He G, Shen C, He S, Chen Y, Guo X (2025) Construction of a ferroptosis-based prediction model for the prognosis of MYCN-amplified neuroblastoma and screening and verification of target sites. Hereditas. https:\/\/doi.org\/10.1186\/s41065-025-00413-8","journal-title":"Hereditas"},{"key":"5021_CR58","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","volume":"84","author":"N Van Eck","year":"2010","unstructured":"Van Eck N, Waltman L (2010) Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics 84:523\u2013538","journal-title":"Scientometrics"},{"key":"5021_CR59","first-page":"338","volume":"39","author":"WN Wan Liah","year":"2025","unstructured":"Wan Liah WN, Zulnaidi H, Kenayathulla HB (2025) Revealing breakthrough trends in teacher effectiveness research: a comprehensive bibliometric analysis with Lotka\u2019s and Price\u2019s law. Int J Educ Manag 39:338\u2013360","journal-title":"Int J Educ Manag"},{"key":"5021_CR60","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1002\/hep.29117","volume":"66","author":"H Wang","year":"2017","unstructured":"Wang H, An P, Xie E, Wu Q, Fang X, Gao H, Zhang Z, Li Y, Wang X, Zhang J, Li G, Yang L, Liu W, Min J, Wang F (2017) Characterization of ferroptosis in murine models of hemochromatosis. Hepatology 66:449\u2013465","journal-title":"Hepatology"},{"key":"5021_CR61","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1038\/s41418-019-0380-z","volume":"27","author":"L Wang","year":"2020","unstructured":"Wang L, Liu Y, Du T, Yang H, Lei L, Guo M, Ding HF, Zhang J, Wang H, Chen X, Yan C (2020) ATF3 promotes erastin-induced ferroptosis by suppressing system Xc\u2013. Cell Death Differ 27:662\u2013675","journal-title":"Cell Death Differ"},{"key":"5021_CR62","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","volume":"569","author":"W Wang","year":"2019","unstructured":"Wang W, Green M, Choi JE, Gij\u00f3n M, Kennedy PD, Johnson JK, Liao P, Lang X, Kryczek I, Sell A, Xia H, Zhou J, Li G, Li J, Li W, Wei S, Vatan L, Zhang H, Szeliga W, Gu W, Liu R, Lawrence TS, Lamb C, Tanno Y, Cie\u015blik M, Stone E, Georgiou G, Chan TA, Chinnaiyan A, Zou W (2019) CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy. Nature 569:270\u2013274","journal-title":"Nature"},{"key":"5021_CR63","first-page":"6190","volume":"13","author":"X Wang","year":"2023","unstructured":"Wang X, Song D, Zhou Z, Jiang Z, Zhang N, Zhang H, Xia D (2023) A comprehensive and visualized analysis of relationship between ferroptosis and tumor using bibliometrics and bioinformatics. Am J Cancer Res 13:6190\u20136209","journal-title":"Am J Cancer Res"},{"key":"5021_CR64","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-025-14134-8","author":"X Wang","year":"2025","unstructured":"Wang X, Zhang W, Liang K, Wang Y, Zhang J, Wang J, Li A, Yun Y, Liu H, Sun Y (2025) Identification of m6 A-regulated ferroptosis biomarkers for prognosis in laryngeal cancer. BMC Cancer. https:\/\/doi.org\/10.1186\/s12885-025-14134-8","journal-title":"BMC Cancer"},{"key":"5021_CR65","doi-asserted-by":"crossref","unstructured":"Wang Z, Zhang H, Wang L, Ma Z, Cui Ya, Fu H, Yu C (2023b) Bibliometric analysis of ferroptosis: a comprehensive evaluation of its contribution to cancer immunity and immunotherapy. Front Oncol 13:1183405","DOI":"10.3389\/fonc.2023.1183405"},{"key":"5021_CR66","doi-asserted-by":"crossref","unstructured":"Wei T, Qin Y, Lin X, Wang X, Chen S, Chen X, Yan N, Wei X, Zhang Z, Wei B (2025) Mapping the future: bibliometric insights into ferroptosis and diabetic nephropathy. Front Physiol 16:1516466","DOI":"10.3389\/fphys.2025.1516466"},{"key":"5021_CR67","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.bbrc.2019.01.090","volume":"510","author":"Q Wen","year":"2019","unstructured":"Wen Q, Liu J, Kang R, Zhou B, Tang D (2019) The release and activity of HMGB1 in ferroptosis. Biochem Biophys Res Commun 510:278\u2013283","journal-title":"Biochem Biophys Res Commun"},{"key":"5021_CR68","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/s41420-023-01542-7","volume":"9","author":"H Wu","year":"2023","unstructured":"Wu H, Cheng K, Li C (2023) Ferroptosis, necroptosis, pyroptosis, and cuproptosis in cancer: a comparative bibliometric analysis. Cell Death Discov 9:238","journal-title":"Cell Death Discov"},{"key":"5021_CR69","doi-asserted-by":"crossref","unstructured":"Wu H, Wang Y, Tong L, Yan H, Sun Z (2021) Global research trends of ferroptosis: a rapidly evolving field with enormous potential. Front Cell Dev Biol 9:646311","DOI":"10.3389\/fcell.2021.646311"},{"key":"5021_CR70","doi-asserted-by":"publisher","first-page":"1604652","DOI":"10.3389\/fimmu.2025.1604652","volume":"16","author":"S Xia","year":"2025","unstructured":"Xia S, Li L, Shi Z, Sun N, He Y (2025) Ferroptosis in osteoarthritis: metabolic reprogramming, immunometabolic crosstalk, and targeted intervention strategies. Frontiers in Immunology 16:1604652","journal-title":"Frontiers in Immunology"},{"key":"5021_CR71","doi-asserted-by":"crossref","unstructured":"Xie L, Zhang Y, Niu X, Kang Y, Li W, Yao J (2025) A comprehensive bibliometric analysis of ferroptosis in tumor resistance: development and emerging trends. Front Immunol 16:1580222","DOI":"10.3389\/fimmu.2025.1580222"},{"key":"5021_CR72","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-025-03629-2","author":"L Xiong","year":"2025","unstructured":"Xiong L, Gao X, Wang L, Luo L, Su J, Wang Y, Shen Y (2025) The influence of ferroptosis-associated gene HSPA5 on the prognosis and immune evasion of lung adenocarcinoma. Discov Oncol. https:\/\/doi.org\/10.1007\/s12672-025-03629-2","journal-title":"Discov Oncol"},{"key":"5021_CR73","doi-asserted-by":"crossref","unstructured":"Yang L, An X, Yang S, Lin X, Chen Z, Xue Q, Chen X, Wang Y, Yan D, Chen S, Fan Y, Tang D, Yu W, Liu J, Chen X (2025) The deubiquitinase USP24 suppresses ferroptosis in triple-negative breast cancer by stabilizing DHODH protein. Cell Death Dis 16(1):564","DOI":"10.1038\/s41419-025-07895-4"},{"key":"5021_CR74","doi-asserted-by":"publisher","first-page":"E4966","DOI":"10.1073\/pnas.1603244113","volume":"113","author":"WS Yang","year":"2016","unstructured":"Yang WS, Kim KJ, Gaschler MM, Patel M, Shchepinov MS, Stockwell BR (2016) Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc Natl Acad Sci U S A 113:E4966\u2013E4975","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5021_CR75","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","volume":"156","author":"WS Yang","year":"2014","unstructured":"Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, Stockwell BR (2014) Regulation of ferroptotic cancer cell death by GPX4. Cell 156:317\u2013331","journal-title":"Cell"},{"key":"5021_CR76","doi-asserted-by":"crossref","unstructured":"Yao F, Guo F, Sun C, Wang E, Wang H, Li N (2025a) Bibliometric analysis of ferroptosis: a comprehensive evaluation of its contribution to lung cancer. Front Genet 15:1449491","DOI":"10.3389\/fgene.2024.1449491"},{"key":"5021_CR77","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-025-00779-y","author":"X Yao","year":"2025","unstructured":"Yao X, Shen X, Fan Y, Wang H (2025) TRIM39-mediated deubiquitination upregulates RNF168 to evade autophagy-ferroptosis in triple-negative breast cancer. NPJ Breast Cancer. https:\/\/doi.org\/10.1038\/s41523-025-00779-y","journal-title":"NPJ Breast Cancer"},{"key":"5021_CR78","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s13024-024-00728-6","volume":"19","author":"A Yehia","year":"2024","unstructured":"Yehia A, Abulseoud OA (2024) Melatonin: a ferroptosis inhibitor with potential therapeutic efficacy for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration. Mol Neurodegener 19:36","journal-title":"Mol Neurodegener"},{"key":"5021_CR79","doi-asserted-by":"publisher","first-page":"1640497","DOI":"10.3389\/fmed.2025.1640497","volume":"12","author":"M Yu","year":"2025","unstructured":"Yu M, Cui W, Hu Y, Song W, Wang Z, Chen W, Ji X, Tang C, Lv J, Hao T (2025) Ferroptosis research based on bibliometric and visual analysis: mechanism exploration and clinical application prospects in gastric cancer, prostate cancer, leukemia, and brain tumors. Front Med (Lausanne) 12:1640497","journal-title":"Front Med (Lausanne)"},{"key":"5021_CR80","doi-asserted-by":"publisher","unstructured":"Yu W, Jing Z, Tang J, Chen J (2025b) A novel defined risk signature of ferroptosis-related lncRNAs for predicting prognosis, immune infiltration, and chemotherapy response in multiple myeloma. Discov Oncol 16. https:\/\/doi.org\/10.1007\/s12672-025-01947-z","DOI":"10.1007\/s12672-025-01947-z"},{"key":"5021_CR81","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1007\/s12672-025-03332-2","volume":"16","author":"H Yuan","year":"2025","unstructured":"Yuan H, Hua Z, Zhang H, Xu D (2025) Ferroptosis and ovarian cancer: a bibliometric study and visualization analysis. Discover Oncol 16:1572","journal-title":"Discover Oncol"},{"key":"5021_CR82","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1016\/j.bbrc.2016.08.124","volume":"478","author":"H Yuan","year":"2016","unstructured":"Yuan H, Li X, Zhang X, Kang R, Tang D (2016) Identification of ACSL4 as a biomarker and contributor of ferroptosis. Biochem Biophys Res Commun 478:1338\u20131343","journal-title":"Biochem Biophys Res Commun"},{"key":"5021_CR83","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-85774-w","author":"J Yuan","year":"2025","unstructured":"Yuan J, Liu C, Jiang C, Liu N, Yang Z, Xing H (2025) RSL3 induces ferroptosis by activating the NF-\u03baB signalling pathway to enhance the chemosensitivity of triple-negative breast cancer cells to paclitaxel. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-025-85774-w","journal-title":"Sci Rep"},{"key":"5021_CR84","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2025.15308","author":"LR Zeng","year":"2025","unstructured":"Zeng LR, Zhu GH, Mei HB, Yang G (2025) Signature of immune infiltration\u2011related ferroptosis genes to predict the prognosis of patients with osteosarcoma. Oncol Lett. https:\/\/doi.org\/10.3892\/ol.2025.15308","journal-title":"Oncol Lett"},{"key":"5021_CR85","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-025-02078-7","author":"Y Zeng","year":"2025","unstructured":"Zeng Y, Xu Z, Huang J, Yi Q, Chen X, Wang J, Du Z, Tian J, Yan Y (2025) THEM6 modulates carboplatin sensitivity by regulating ferroptosis through FDFT1 in triple-negative breast cancer. Breast Cancer Res. https:\/\/doi.org\/10.1186\/s13058-025-02078-7","journal-title":"Breast Cancer Res"},{"key":"5021_CR86","doi-asserted-by":"publisher","first-page":"686726","DOI":"10.3389\/fonc.2021.686726","volume":"11","author":"J Zhang","year":"2021","unstructured":"Zhang J, Song L, Xu L, Fan Y, Wang T, Tian W, Ju J, Xu H (2021) Knowledge domain and emerging trends in ferroptosis research: a bibliometric and knowledge-map analysis. Frontiers in Oncology 11:686726","journal-title":"Frontiers in Oncology"},{"key":"5021_CR87","doi-asserted-by":"crossref","unstructured":"Zhang W, Gu J, Chen Y, Jiang G, Gonzalez-Rivas D, Ma M, Chen C (2025) Emerging research themes in ferroptosis research for non-small cell lung cancer: a bibliometric and visualized analysis. Front Immunol 16:1563108","DOI":"10.3389\/fimmu.2025.1563108"},{"key":"5021_CR88","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.chembiol.2019.01.008","volume":"26","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Tan H, Daniels JD, Zandkarimi F, Liu H, Brown LM, Uchida K, O\u2019Connor OA, Stockwell BR (2019) Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model. Cell Chem Biol 26:623\u2013633.e629","journal-title":"Cell Chem Biol"},{"key":"5021_CR89","doi-asserted-by":"publisher","first-page":"e42242","DOI":"10.1016\/j.heliyon.2025.e42242","volume":"11","author":"X Zheng","year":"2025","unstructured":"Zheng X, Diao M, Tong S, Yang S, Lin J, Zhuo S, Wang T, Dai J, Chen S, Wang K (2025) Global research landscape and hotspots for ferroptosis in glioma: a comprehensive bibliometric and visual analysis. Heliyon 11:e42242","journal-title":"Heliyon"},{"key":"5021_CR90","doi-asserted-by":"publisher","first-page":"e24810","DOI":"10.1016\/j.heliyon.2024.e24810","volume":"10","author":"H Zhou","year":"2024","unstructured":"Zhou H, Mao Y, Zhou Z (2024) Charting the course of ferroptosis research in lung cancer: insights from a bibliometric analysis. Heliyon 10:e24810","journal-title":"Heliyon"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05021-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05021-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05021-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:03:22Z","timestamp":1782101002000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05021-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,22]]},"references-count":90,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["5021"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05021-5","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,22]]},"assertion":[{"value":"25 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"There is no form of human subject involved in this manuscript; therefore, ethics approval is not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}