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Herein, dose- and time-dependent in vitro anticancer activity studies of anti-inflammatory drugs, including celecoxib (\n                    <jats:bold>C<\/jats:bold>\n                    ), indomethacin (\n                    <jats:bold>I<\/jats:bold>\n                    ), and meloxicam (\n                    <jats:bold>M<\/jats:bold>\n                    ), in combination with natural products (taxifolin (\n                    <jats:bold>T<\/jats:bold>\n                    ), quercetin (\n                    <jats:bold>Q<\/jats:bold>\n                    ), and rutin (\n                    <jats:bold>R<\/jats:bold>\n                    )) and doxorubicin (Dox), were carried out in MDA-MB-231, BT-20, MCF-7, and HT-29 human cancer cell lines. Drug\n                    <jats:bold>C<\/jats:bold>\n                    demonstrated significant anticancer activity in cancer cells with natural products (&lt;\u200940 \u00b5M) and Dox (&lt;\u20095 \u00b5M). The antiulcerative effect of the most promising drug\n                    <jats:bold>C<\/jats:bold>\n                    in combination with\n                    <jats:bold>T<\/jats:bold>\n                    and\n                    <jats:bold>R<\/jats:bold>\n                    in rats was carried out. The histopathological analysis suggests that the substitution of\n                    <jats:bold>R<\/jats:bold>\n                    with\n                    <jats:bold>T<\/jats:bold>\n                    , when combined with drug\n                    <jats:bold>C<\/jats:bold>\n                    , leads to a statistically significant improvement in the amelioration of gastric mucosal injury. Additionally, in silico studies have been conducted against the important cancer drug target sphingosine kinase 1 (SphK1). The obtained results highlight that drug\n                    <jats:bold>C<\/jats:bold>\n                    and\n                    <jats:bold>T<\/jats:bold>\n                    may be potential inhibitor candidates as SphK1 inhibitors for targeted cancer therapy. Overall, the combination of drug\n                    <jats:bold>C<\/jats:bold>\n                    with\n                    <jats:bold>T<\/jats:bold>\n                    has shown promising results, anticancer effects in breast and colon cancer cells and antiulcerative effects in rats.\n                  <\/jats:p>","DOI":"10.1007\/s00210-026-05041-1","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T01:29:35Z","timestamp":1770168575000},"page":"10487-10503","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A comparative study of some NSAIDs with natural products: integrating in vitro anticancer efficacy, in vivo antiulcerative effect, histochemistry, and in silico analysis"],"prefix":"10.1007","volume":"399","author":[{"given":"Rabia Selina","family":"Hal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prestige Vialli","family":"Moyo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadircan","family":"Ural","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merve","family":"S\u0131k\u0131k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayla Nur","family":"Demiral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Akif","family":"Ovali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alper","family":"Onder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neslihan","family":"Kaya Terzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berrin","family":"Erkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferah","family":"Comert Onder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"issue":"1","key":"5041_CR1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-023-04333-w","volume":"24","author":"DH Abu-Baih","year":"2024","unstructured":"Abu-Baih DH, Gomaa AA, Abdel-Wahab NM, Abdelaleem ER, Zaher AMA, Hassan NF, Bringmann G, Abdelmohsen UR, Altemani FH, Algehainy NA, Mokhtar FA, Abdelwahab MF (2024) Apium extract alleviates indomethacin-induced gastric ulcers in rats via modulating the VEGF and IK-\u03baB\/NF-\u03baB p65 signaling pathway: insights from in silico and in vivo investigations. 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