{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:55:04Z","timestamp":1781513704906,"version":"3.54.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s00210-026-05087-1","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:39:59Z","timestamp":1771475999000},"page":"11527-11544","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the causal relationship between plasma proteins and obstructive sleep apnea: a study using genome-wide Mendelian randomization, single-cell RNA sequencing analysis, and network pharmacology"],"prefix":"10.1007","volume":"399","author":[{"given":"Lingzhi","family":"Duan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqing","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuye","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengfu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"5087_CR1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/510105","volume":"2015","author":"A Adegunsoye","year":"2015","unstructured":"Adegunsoye A, Balachandran J (2015) Inflammatory response mechanisms exacerbating hypoxemia in coexistent pulmonary fibrosis and sleep apnea. Mediators Inflamm 2015:510105. https:\/\/doi.org\/10.1155\/2015\/510105","journal-title":"Mediators Inflamm"},{"issue":"4","key":"5087_CR2","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1002\/jrsm.1346","volume":"10","author":"J Bowden","year":"2019","unstructured":"Bowden J, Holmes MV (2019) Meta-analysis and Mendelian randomization: a review. Res Synth Methods 10(4):486\u2013496. https:\/\/doi.org\/10.1002\/jrsm.1346","journal-title":"Res Synth Methods"},{"key":"5087_CR3","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.15555.3","volume":"4","author":"S Burgess","year":"2023","unstructured":"Burgess S, Davey Smith G, Davies NM et al (2023) Guidelines for performing Mendelian randomization investigations: update for summer 2023. Wellcome Open Res 4:186. https:\/\/doi.org\/10.12688\/wellcomeopenres.15555.3","journal-title":"Wellcome Open Res"},{"issue":"3","key":"5087_CR4","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201700067","volume":"12","author":"A Christensson","year":"2018","unstructured":"Christensson A, Ash JA, DeLisle RK et al (2018) The impact of the glomerular filtration rate on the human plasma proteome. Proteomics Clin Appl 12(3):e1700067. https:\/\/doi.org\/10.1002\/prca.201700067","journal-title":"Proteomics Clin Appl"},{"issue":"21","key":"5087_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111396","volume":"22","author":"LP Chuang","year":"2021","unstructured":"Chuang LP, Wu HP, Lee LA et al (2021) Elevated monocytic interleukin-8 expression under intermittent hypoxia condition and in obstructive sleep apnea patients. Int J Mol Sci 22(21):11396. https:\/\/doi.org\/10.3390\/ijms222111396","journal-title":"Int J Mol Sci"},{"issue":"2","key":"5087_CR6","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01465-2022","volume":"61","author":"R Cortese","year":"2023","unstructured":"Cortese R, Adams TS, Cataldo KH et al (2023) Single-cell RNA-seq uncovers cellular heterogeneity and provides a signature for paediatric sleep apnoea. Eur Respir J 61(2):2201465. https:\/\/doi.org\/10.1183\/13993003.01465-2022","journal-title":"Eur Respir J"},{"issue":"1","key":"5087_CR7","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00777-2023","volume":"10","author":"C Cubillos-Zapata","year":"2024","unstructured":"Cubillos-Zapata C, Troncoso-Acevedo F, D\u00edaz-Garc\u00eda E et al (2024) Sleep apnoea increases biomarkers of immune evasion, lymphangiogenesis and tumour cell aggressiveness in high-risk patients and those with established lung cancer. ERJ Open Res 10(1):00777-2023. https:\/\/doi.org\/10.1183\/23120541.00777-2023","journal-title":"ERJ Open Res"},{"issue":"11","key":"5087_CR8","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1164\/rccm.202106-1445OC","volume":"205","author":"E D\u00edaz-Garc\u00eda","year":"2022","unstructured":"D\u00edaz-Garc\u00eda E, Garc\u00eda-Tovar S, Alfaro E et al (2022) Inflammasome activation: a keystone of proinflammatory response in obstructive sleep apnea. Am J Respir Crit Care Med 205(11):1337\u20131348. https:\/\/doi.org\/10.1164\/rccm.202106-1445OC","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"5087_CR9","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1002\/eji.201141550","volume":"41","author":"CA Dinarello","year":"2011","unstructured":"Dinarello CA (2011) A clinical perspective of IL-1\u03b2 as the gatekeeper of inflammation. Eur J Immunol 41(5):1203\u20131217. https:\/\/doi.org\/10.1002\/eji.201141550","journal-title":"Eur J Immunol"},{"key":"5087_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.139359","volume":"293","author":"X Ding","year":"2025","unstructured":"Ding X, Zuo Y, Liu Z et al (2025) Recombinant neurotrophin-3 with the ability to penetrate the blood-brain barrier: a new strategy against Alzheimer\u2019s disease. Int J Biol Macromol 293:139359. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.139359","journal-title":"Int J Biol Macromol"},{"issue":"19","key":"5087_CR11","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1001\/jama.2017.17219","volume":"318","author":"CA Emdin","year":"2017","unstructured":"Emdin CA, Khera AV, Kathiresan S (2017) Mendelian randomization. JAMA 318(19):1925\u20131926. https:\/\/doi.org\/10.1001\/jama.2017.17219","journal-title":"JAMA"},{"key":"5087_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2025.111544","author":"SK Fang","year":"2025","unstructured":"Fang SK, Hu F, Zhang Y et al (2025) Enriched environment ameliorates neurobehavioral abnormalities, hippocampal inflammation, and synaptic dysfunction in adult male mice exposed to intermittent hypoxia during pregnancy. Brain Res Bull. https:\/\/doi.org\/10.1016\/j.brainresbull.2025.111544","journal-title":"Brain Res Bull"},{"issue":"12","key":"5087_CR13","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1038\/s41588-021-00978-w","volume":"53","author":"E Ferkingstad","year":"2021","unstructured":"Ferkingstad E, Sulem P, Atlason BA et al (2021) Large-scale integration of the plasma proteome with genetics and disease. Nat Genet 53(12):1712\u20131721. https:\/\/doi.org\/10.1038\/s41588-021-00978-w","journal-title":"Nat Genet"},{"issue":"8","key":"5087_CR14","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.3978\/j.issn.2072-1439.2015.06.11","volume":"7","author":"KA Franklin","year":"2015","unstructured":"Franklin KA, Lindberg E (2015) Obstructive sleep apnea is a common disorder in the population-a review on the epidemiology of sleep apnea. J Thorac Dis 7(8):1311\u20131322. https:\/\/doi.org\/10.3978\/j.issn.2072-1439.2015.06.11","journal-title":"J Thorac Dis"},{"key":"5087_CR15","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baz046","volume":"2019","author":"O Franz\u00e9n","year":"2019","unstructured":"Franz\u00e9n O, Gan LM, Bj\u00f6rkegren JLM (2019) PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data. Database 2019:baz046. https:\/\/doi.org\/10.1093\/database\/baz046","journal-title":"Database"},{"issue":"13","key":"5087_CR16","doi-asserted-by":"publisher","first-page":"10651","DOI":"10.1039\/c8nj00852c","volume":"42","author":"R Ganduri","year":"2018","unstructured":"Ganduri R, Singh V, Biswas A, Karothu DP, Sekar K, Balaji KN, Guru Row TN (2018) Structural and biological evaluation of halogen derivatives of 1,9-pyrazoloanthrones towards the design of a specific potent inhibitor of c-Jun-N-terminal kinase (JNK). New J Chem 42(13):10651\u201310660. https:\/\/doi.org\/10.1039\/c8nj00852c","journal-title":"New J Chem"},{"key":"5087_CR17","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6006127","volume":"2022","author":"SP Gunta","year":"2022","unstructured":"Gunta SP, Jakulla RS, Ubaid A et al (2022) Obstructive sleep apnea and cardiovascular diseases: sad realities and untold truths regarding care of patients in 2022. Cardiovasc Ther 2022:6006127. https:\/\/doi.org\/10.1155\/2022\/6006127","journal-title":"Cardiovasc Ther"},{"issue":"1","key":"5087_CR18","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202402813R","volume":"39","author":"S Han","year":"2025","unstructured":"Han S, Huang J, Yang C, Feng J, Wang Y (2025) The histone demethylase KDM6B links obstructive sleep apnea to idiopathic pulmonary fibrosis. FASEB J 39(1):e70306. https:\/\/doi.org\/10.1096\/fj.202402813R","journal-title":"FASEB J"},{"issue":"4","key":"5087_CR19","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1152\/jn.00240.2021","volume":"126","author":"Y He","year":"2021","unstructured":"He Y, Liu Z, Huang Y, Li B (2021) Role of the p38MAPK signaling pathway in hippocampal neuron autophagy in rats with chronic intermittent hypoxia. J Neurophysiol 126(4):1112\u20131121. https:\/\/doi.org\/10.1152\/jn.00240.2021","journal-title":"J Neurophysiol"},{"issue":"1","key":"5087_CR20","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-024-01523-x","volume":"15","author":"D He","year":"2024","unstructured":"He D, Che X, Zhang H et al (2024) Integrated single-cell analysis reveals heterogeneity and therapeutic insights in osteosarcoma. Discov Oncol 15(1):669. https:\/\/doi.org\/10.1007\/s12672-024-01523-x","journal-title":"Discov Oncol"},{"issue":"1","key":"5087_CR21","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-025-03282-7","volume":"29","author":"Y He","year":"2025","unstructured":"He Y, Xu X, Lv M et al (2025) Risk factors of high inflammatory state in pediatric obstructive sleep apnea. Sleep Breath 29(1):116. https:\/\/doi.org\/10.1007\/s11325-025-03282-7","journal-title":"Sleep Breath"},{"key":"5087_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1320954","volume":"14","author":"J Huang","year":"2023","unstructured":"Huang J, Zhang H, Cao L et al (2023) Ferroptosis-related genes are considered as potential targets for CPAP treatment of obstructive sleep apnea. Front Neurol 14:1320954. https:\/\/doi.org\/10.3389\/fneur.2023.1320954","journal-title":"Front Neurol"},{"issue":"12","key":"5087_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26125855","volume":"26","author":"U Karwowska","year":"2025","unstructured":"Karwowska U, Kudrycka A, Pierzcha\u0142a K et al (2025) Twelve-month CPAP therapy modulates BDNF levels in patients with severe obstructive sleep apnea: implications for metabolic and treatment compliance. Int J Mol Sci 26(12):5855. https:\/\/doi.org\/10.3390\/ijms26125855","journal-title":"Int J Mol Sci"},{"issue":"1","key":"5087_CR24","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.15","volume":"1","author":"P L\u00e9vy","year":"2015","unstructured":"L\u00e9vy P, Kohler M, McNicholas WT et al (2015) Obstructive sleep apnoea syndrome. Nat Rev Dis Primers 1(1):15015. https:\/\/doi.org\/10.1038\/nrdp.2015.15","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"5087_CR25","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-021-00427-8","volume":"28","author":"D Li","year":"2022","unstructured":"Li D, Xu N, Hou Y et al (2022) Abnormal lipid droplets accumulation induced cognitive deficits in obstructive sleep apnea syndrome mice via JNK\/SREBP\/ACC pathway but not through PDP1\/PDC pathway. Mol Med 28(1):3. https:\/\/doi.org\/10.1186\/s10020-021-00427-8","journal-title":"Mol Med"},{"key":"5087_CR26","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.neuroscience.2023.12.006","volume":"539","author":"C Li","year":"2024","unstructured":"Li C, Zhao Z, Jin J, Zhao C, Zhao B, Liu Y (2024) NLRP3-GSDMD-dependent IL-1\u03b2 secretion from microglia mediates learning and memory impairment in a chronic intermittent hypoxia-induced mouse model. Neuroscience 539:51\u201365. https:\/\/doi.org\/10.1016\/j.neuroscience.2023.12.006","journal-title":"Neuroscience"},{"issue":"3","key":"5087_CR27","doi-asserted-by":"publisher","DOI":"10.1177\/00368504251358106","volume":"108","author":"SY Li","year":"2025","unstructured":"Li SY, Cui S, Nan QY et al (2025) Dapagliflozin attenuates nicotine-induced apoptosis by targeting the ASK1\/p38\/JNK apoptotic pathway in HK-2 cells. Sci Prog 108(3):368504251358106. https:\/\/doi.org\/10.1177\/00368504251358106","journal-title":"Sci Prog"},{"issue":"W1","key":"5087_CR28","doi-asserted-by":"publisher","first-page":"W159","DOI":"10.1093\/nar\/gkac394","volume":"50","author":"Y Liu","year":"2022","unstructured":"Liu Y, Yang X, Gan J, Chen S, Xiao ZX, Cao Y (2022) CB-Dock2: improved protein-ligand blind docking by integrating cavity detection, docking and homologous template fitting. Nucleic Acids Res 50(W1):W159\u2013W164. https:\/\/doi.org\/10.1093\/nar\/gkac394","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"5087_CR29","doi-asserted-by":"publisher","first-page":"352","DOI":"10.26355\/eurrev_201901_16783","volume":"23","author":"HD Lu","year":"2019","unstructured":"Lu HD, Liu ZC, Zhou LY, Zhou J, Feng XR, Wang B (2019) Influence of the TLR4-mediated p38MAPK signaling pathway on chronic intermittent hypoxic-induced rat\u2019s oxidative stress and inflammatory cytokines in rats. Eur Rev Med Pharmacol Sci 23(1):352\u2013360. https:\/\/doi.org\/10.26355\/eurrev_201901_16783","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"14","key":"5087_CR30","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1093\/bioinformatics\/btt285","volume":"29","author":"W Luo","year":"2013","unstructured":"Luo W, Brouwer C (2013) Pathview: an R\/Bioconductor package for pathway-based data integration and visualization. Bioinformatics 29(14):1830\u20131831. https:\/\/doi.org\/10.1093\/bioinformatics\/btt285","journal-title":"Bioinformatics"},{"issue":"11","key":"5087_CR31","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1182\/blood.2019000944","volume":"136","author":"L Luzzatto","year":"2020","unstructured":"Luzzatto L, Ally M, Notaro R (2020) Glucose-6-phosphate dehydrogenase deficiency. Blood 136(11):1225\u20131240. https:\/\/doi.org\/10.1182\/blood.2019000944","journal-title":"Blood"},{"key":"5087_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2025.106255","author":"VV Massoni","year":"2025","unstructured":"Massoni VV, Silva CMPC, Araujo LDC et al (2025) Expression of NET markers in experimental apical periodontitis induced in mice. Arch Oral Biol. https:\/\/doi.org\/10.1016\/j.archoralbio.2025.106255","journal-title":"Arch Oral Biol"},{"issue":"6","key":"5087_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065478","volume":"24","author":"PG Meliante","year":"2023","unstructured":"Meliante PG, Zoccali F, Cascone F et al (2023) Molecular pathology, oxidative stress, and biomarkers in obstructive sleep apnea. Int J Mol Sci 24(6):5478. https:\/\/doi.org\/10.3390\/ijms24065478","journal-title":"Int J Mol Sci"},{"issue":"23","key":"5087_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/nu15234948","volume":"15","author":"E Merzon","year":"2023","unstructured":"Merzon E, Magen E, Ashkenazi S et al (2023) The association between glucose 6-phosphate dehydrogenase deficiency and attention deficit\/hyperactivity disorder. Nutrients 15(23):4948. https:\/\/doi.org\/10.3390\/nu15234948","journal-title":"Nutrients"},{"key":"5087_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2023.148029","volume":"896","author":"Y Que","year":"2024","unstructured":"Que Y, Meng H, Ding Y, Fan J, Du Y, Xu G (2024) Investigation of the shared gene signatures and molecular mechanisms between obstructive sleep apnea syndrome and asthma. Gene 896:148029. https:\/\/doi.org\/10.1016\/j.gene.2023.148029","journal-title":"Gene"},{"issue":"12","key":"5087_CR36","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1089\/gtmb.2024.0395","volume":"28","author":"S Rasouli","year":"2024","unstructured":"Rasouli S, Alizadeh Severi A, Abdolsamadi M et al (2024) The association between the C-reactive protein gene variants rs1130864 and rs2794521 and obstructive sleep apnea in the Iranian Kurdish population. Genet Test Mol Biomarkers 28(12):485\u2013491. https:\/\/doi.org\/10.1089\/gtmb.2024.0395","journal-title":"Genet Test Mol Biomarkers"},{"issue":"3","key":"5087_CR37","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1007\/s11325-024-02997-3","volume":"28","author":"C Shen","year":"2024","unstructured":"Shen C, Zong D, Peng Y, Zhou L, Liu T, Ouyang R (2024) Effect of continuous positive airway pressure treatment on Th17\/Treg imbalance in patients with obstructive sleep apnea and a preliminary study on its mechanism. Sleep Breath 28(3):1231\u20131243. https:\/\/doi.org\/10.1007\/s11325-024-02997-3","journal-title":"Sleep Breath"},{"issue":"1","key":"5087_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-87662-9","volume":"15","author":"XF Shi","year":"2025","unstructured":"Shi XF, He X, Sun ZR, Duo J, Yang H (2025) Different expression of circulating microRNA profile in tibetan OSAHS with metabolic syndrome patients. Sci Rep 15(1):3013. https:\/\/doi.org\/10.1038\/s41598-025-87662-9","journal-title":"Sci Rep"},{"issue":"1","key":"5087_CR39","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-024-01356-x","volume":"16","author":"S Si","year":"2024","unstructured":"Si S, Liu H, Xu L, Zhan S (2024) Identification of novel therapeutic targets for chronic kidney disease and kidney function by integrating multi-omics proteome with transcriptome. Genome Med 16(1):84. https:\/\/doi.org\/10.1186\/s13073-024-01356-x","journal-title":"Genome Med"},{"issue":"1","key":"5087_CR40","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41576-020-0268-2","volume":"22","author":"K Suhre","year":"2021","unstructured":"Suhre K, McCarthy MI, Schwenk JM (2021) Genetics meets proteomics: perspectives for large population-based studies. Nat Rev Genet 22(1):19\u201337. https:\/\/doi.org\/10.1038\/s41576-020-0268-2","journal-title":"Nat Rev Genet"},{"issue":"7","key":"5087_CR41","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1002\/hep4.1354","volume":"3","author":"SS Sundaram","year":"2019","unstructured":"Sundaram SS, Swiderska-Syn M, Sokol RJ et al (2019) Nocturnal hypoxia activation of the hedgehog signaling pathway affects pediatric nonalcoholic fatty liver disease severity. Hepatol Commun 3(7):883\u2013893. https:\/\/doi.org\/10.1002\/hep4.1354","journal-title":"Hepatol Commun"},{"issue":"D1","key":"5087_CR42","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk D, Kirsch R, Koutrouli M et al (2023) The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res 51(D1):D638\u2013D646. https:\/\/doi.org\/10.1093\/nar\/gkac1000","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"5087_CR43","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-024-03252-2","volume":"20","author":"L Wang","year":"2025","unstructured":"Wang L, Wang Y, Jiao T et al (2025) Effects of continuous positive airway pressure treatment on arterial stiffness and inflammatory factors in patients with coronary heart disease complicated with obstructive sleep apnea. J Cardiothorac Surg 20(1):59. https:\/\/doi.org\/10.1186\/s13019-024-03252-2","journal-title":"J Cardiothorac Surg"},{"issue":"3","key":"5087_CR44","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3390\/clockssleep4030027","volume":"4","author":"Z Wei","year":"2022","unstructured":"Wei Z, Chen Y, Upender RP (2022) Adipokines in sleep disturbance and metabolic dysfunction: insights from network analysis. Clocks & Sleep 4(3):321\u2013331. https:\/\/doi.org\/10.3390\/clockssleep4030027","journal-title":"Clocks & Sleep"},{"issue":"42","key":"5087_CR45","doi-asserted-by":"publisher","first-page":"17027","DOI":"10.1021\/acs.analchem.4c05111","volume":"96","author":"X Wu","year":"2024","unstructured":"Wu X, Li B, Wang Y et al (2024) Microfluidic chip-based automatic system for sequencing patient-derived organoids at the single-cell level. Anal Chem 96(42):17027\u201317036. https:\/\/doi.org\/10.1021\/acs.analchem.4c05111","journal-title":"Anal Chem"},{"issue":"8","key":"5087_CR46","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1002\/oby.23809","volume":"31","author":"X Xiang","year":"2023","unstructured":"Xiang X, Zhu Y, Pan X et al (2023) ER stress aggravates diaphragm weakness through activating PERK\/JNK signaling in obesity hypoventilation syndrome. Obesity Silver Spring 31(8):2076\u20132089. https:\/\/doi.org\/10.1002\/oby.23809","journal-title":"Obesity Silver Spring"},{"issue":"9","key":"5087_CR47","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202402832R","volume":"39","author":"F Xu","year":"2025","unstructured":"Xu F, He Y, Sun Y et al (2025) The TNFRSF1B connection: implications for androgenetic alopecia pathogenesis and treatment. FASEB J 39(9):e70553. https:\/\/doi.org\/10.1096\/fj.202402832R","journal-title":"FASEB J"},{"key":"5087_CR48","doi-asserted-by":"publisher","first-page":"2581","DOI":"10.1016\/j.ijbiomac.2022.10.041","volume":"222","author":"Y Yan","year":"2022","unstructured":"Yan Y, Guan S, Wang S, Xu J, Sun C (2022) Synthesis and characterization of protocatechuic acid grafted carboxymethyl chitosan with oxidized sodium alginate hydrogel through the Schiff\u2019s base reaction. Int J Biol Macromol 222:2581\u20132593. https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.10.041","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"5087_CR49","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1177\/11206721221099247","volume":"33","author":"Y Yang","year":"2023","unstructured":"Yang Y, Somani S (2023) Impact of obstructive sleep apnea on the expression of inflammatory mediators in diabetic macular edema. Eur J Ophthalmol 33(1):415\u2013420. https:\/\/doi.org\/10.1177\/11206721221099247","journal-title":"Eur J Ophthalmol"},{"issue":"1","key":"5087_CR50","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-06171-z","volume":"7","author":"L Yang","year":"2024","unstructured":"Yang L, He Y, Liu S et al (2024) Adipocyte-derived exosomes from obstructive sleep apnoea rats aggravate MASLD by TCONS_00039830\/miR-455-3p\/Smad2 axis. Commun Biol 7(1):492. https:\/\/doi.org\/10.1038\/s42003-024-06171-z","journal-title":"Commun Biol"},{"issue":"1","key":"5087_CR51","doi-asserted-by":"publisher","DOI":"10.1038\/srep14507","volume":"5","author":"X Yin","year":"2015","unstructured":"Yin X, Zhang X, Lv C et al (2015) Protocatechuic acid ameliorates neurocognitive functions impairment induced by chronic intermittent hypoxia. Sci Rep 5(1):14507. https:\/\/doi.org\/10.1038\/srep14507","journal-title":"Sci Rep"},{"issue":"18","key":"5087_CR52","doi-asserted-by":"publisher","first-page":"3069","DOI":"10.1093\/bioinformatics\/btv313","volume":"31","author":"M Yoo","year":"2015","unstructured":"Yoo M, Shin J, Kim J et al (2015) DSigDB: drug signatures database for gene set analysis. Bioinformatics 31(18):3069\u20133071. https:\/\/doi.org\/10.1093\/bioinformatics\/btv313","journal-title":"Bioinformatics"},{"issue":"10","key":"5087_CR53","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006680","volume":"6","author":"GH Zhang","year":"2017","unstructured":"Zhang GH, Yu FC, Li Y et al (2017) Prolyl 4-Hydroxylase domain protein 3 overexpression improved obstructive sleep apnea-induced cardiac perivascular fibrosis partially by suppressing endothelial-to-mesenchymal transition. J Am Heart Assoc 6(10):e006680. https:\/\/doi.org\/10.1161\/JAHA.117.006680","journal-title":"J Am Heart Assoc"},{"issue":"2","key":"5087_CR54","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1007\/s11684-024-1113-3","volume":"19","author":"W Zhao","year":"2025","unstructured":"Zhao W, Zhou L, Wang Y, Wang J, Sun YE, Wang Q (2025) Single-cell transcriptome analyses of PBMCs reveal the immunological characteristics of individuals with phlegm-dampness constitution. Front Med 19(2):376\u2013385. https:\/\/doi.org\/10.1007\/s11684-024-1113-3","journal-title":"Front Med"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05087-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05087-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05087-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:19:44Z","timestamp":1781511584000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05087-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,19]]},"references-count":54,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["5087"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05087-1","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6936975\/v1","asserted-by":"object"}]},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,19]]},"assertion":[{"value":"20 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}