{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T09:53:12Z","timestamp":1781517192372,"version":"3.54.1"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s00210-026-05119-w","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T03:32:13Z","timestamp":1771990333000},"page":"11845-11860","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anxiolytic-like effects of p-coumaric acid via GABAergic interaction pathways: an in vivo and in silico study"],"prefix":"10.1007","volume":"399","author":[{"given":"Madhu","family":"Sah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balaram","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh Kumar","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raihan","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Y.","family":"Alshahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Ali","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anik Kumar","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U Ching Aoung","family":"Chak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadia","family":"Akhter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Fazla Alahi","family":"Nikson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shama","family":"Mohanta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. M. Shadid Hossain","family":"Snigdha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Torequl","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anike","family":"Chakrabarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Sakib","family":"Al Hasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"5119_CR1","doi-asserted-by":"publisher","unstructured":"Aburawi SM, Saad JM, Al-Tubuly RA, Eldrogi AF (2024) Ascorbic acid has an anxiolytic-like effect in the presence of flumazenil in rats.\u00a0Mediterr J Pharm Pharm Sci 4(3):57\u201364. https:\/\/doi.org\/10.5281\/zenodo.13751022","DOI":"10.5281\/zenodo.13751022"},{"issue":"22","key":"5119_CR2","doi-asserted-by":"publisher","first-page":"12040","DOI":"10.1080\/07391102.2023.2266524","volume":"42","author":"R Agrawal","year":"2024","unstructured":"Agrawal R, Punarva HB, Heda GO, Vishesh YM, Karunakar P (2024) Vinaliggen: a method to generate ligplots and retrieval of hydrogen and hydrophobic interactions from protein-ligand complexes. J Biomol Struct Dyn 42(22):12040\u201312043","journal-title":"J Biomol Struct Dyn"},{"key":"5119_CR3","doi-asserted-by":"publisher","unstructured":"Al Hasan MS, Bhuia MS, Chowdhury R, Husain Z, Saifuzzaman M, Mia E, Akbor MS, Yana NT, Islam MA, Ansari SA, Ansari IA, Islam MT (2025) Tangeretin enhances sedative activity of diazepam in Swiss mice through GABAA receptor interaction: In vivo and in silico approaches. Neurosci 572:1\u201310.\nhttps:\/\/doi.org\/10.1016\/j.neuroscience.2025.03.004","DOI":"10.1016\/j.neuroscience.2025.03.004"},{"key":"5119_CR4","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.biopha.2016.09.039","volume":"84","author":"V Amalan","year":"2016","unstructured":"Amalan V, Vijayakumar N, Indumathi D, Ramakrishnan A (2016) Antidiabetic and antihyperlipidemic activity of p-coumaric acid in diabetic rats, role of pancreatic GLUT 2: in vivo approach. Biomed Pharmacother 84:230\u2013236","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"5119_CR5","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3109\/13651501.2012.667114","volume":"16","author":"B Bandelow","year":"2012","unstructured":"Bandelow B, Sher L, Bunevicius R, Hollander E, Kasper S, Zohar J, WFSBP Task Force on Anxiety Disorders, OCD and PTSD (2012) Guidelines for the pharmacological treatment of anxiety disorders, obsessive\u2013compulsive disorder and posttraumatic stress disorder in primary care. Int J Psychiatry Clin Pract 16(2):77\u201384","journal-title":"Int J Psychiatry Clin Pract"},{"issue":"11","key":"5119_CR6","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1037\/0003-066X.55.11.1247","volume":"55","author":"DH Barlow","year":"2000","unstructured":"Barlow DH (2000) Unraveling the mysteries of anxiety and its disorders from the perspective of emotion theory. Am Psychol 55(11):1247","journal-title":"Am Psychol"},{"issue":"2","key":"5119_CR7","doi-asserted-by":"publisher","first-page":"75","DOI":"10.4103\/jpgm.JPGM_65_18","volume":"64","author":"MS Bhatia","year":"2018","unstructured":"Bhatia MS, Goyal A (2018) Anxiety disorders in children and adolescents: need for early detection. J Postgrad Med 64(2):75\u201376","journal-title":"J Postgrad Med"},{"issue":"4","key":"5119_CR8","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1007\/s13205-023-03520-3","volume":"13","author":"MS Bhuia","year":"2023","unstructured":"Bhuia MS, Islam T, Rokonuzzman M, Shamsh Prottay AA, Akter F, Hossain MI, Islam MT (2023) Modulatory effects of phytol on the antiemetic property of domperidone, possibly through the D2 receptor interaction pathway: in vivo and in silico studies. 3 Biotech 13(4):116","journal-title":"3 Biotech"},{"issue":"9","key":"5119_CR9","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.3390\/ph16091271","volume":"16","author":"MS Bhuia","year":"2023","unstructured":"Bhuia MS, Rokonuzzman M, Hossain MI, Ansari SA, Ansari IA, Islam T, Islam MT (2023) Anxiolytic-like effects by trans-ferulic acid possibly occur through GABAergic interaction pathways. Pharmaceuticals 16(9):1271","journal-title":"Pharmaceuticals"},{"key":"5119_CR10","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s00210-020-01928-9","volume":"394","author":"T Boeing","year":"2021","unstructured":"Boeing T, Costa P, Venzon L, Meurer M, Mariano LNB, Fran\u00e7a TCS, da Silva LM (2021) Gastric healing effect of p-coumaric acid isolated from Baccharis dracunculifolia DC on animal model. Naunyn-Schmiedebergs Arch Pharmacol 394:49\u201357","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"issue":"8","key":"5119_CR11","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3390\/antiox8080275","volume":"8","author":"YC Boo","year":"2019","unstructured":"Boo YC (2019) P-coumaric acid as an active ingredient in cosmetics: a review focusing on its antimelanogenic effects. Antioxidants 8(8):275","journal-title":"Antioxidants"},{"issue":"11","key":"5119_CR12","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1111\/ijfs.12898","volume":"50","author":"H Boz","year":"2015","unstructured":"Boz H (2015) P-coumaric acid in cereals: presence, antioxidant and antimicrobial effects. Int J Food Sci Technol 50(11):2323\u20132328","journal-title":"Int J Food Sci Technol"},{"issue":"3","key":"5119_CR13","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/S0272-7358(03)00033-3","volume":"23","author":"CR Brewin","year":"2003","unstructured":"Brewin CR, Holmes EA (2003) Psychological theories of posttraumatic stress disorder. Clin Psychol Rev 23(3):339\u2013376","journal-title":"Clin Psychol Rev"},{"issue":"1","key":"5119_CR14","first-page":"30","volume":"38","author":"A Bystritsky","year":"2013","unstructured":"Bystritsky A, Khalsa SS, Cameron ME, Schiffman J (2013) Current diagnosis and treatment of anxiety disorders. Pharm Ther 38(1):30","journal-title":"Pharm Ther"},{"issue":"6","key":"5119_CR15","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1080\/10408440802014238","volume":"38","author":"EJ Calabrese","year":"2008","unstructured":"Calabrese EJ (2008) An assessment of anxiolytic drug screening tests: hormetic dose responses predominate. Crit Rev Toxicol 38(6):489\u2013542","journal-title":"Crit Rev Toxicol"},{"key":"5119_CR16","doi-asserted-by":"crossref","unstructured":"\u00a0Charles DJ (2012) Sources of natural antioxidants and their activities. In: Antioxidant properties of spices, herbs and other sources. Springer New York, New York, pp 65-138. https:\/\/link.springer.com\/chapter\/10.1007\/978-1-4614-4310-0_4","DOI":"10.1007\/978-1-4614-4310-0_4"},{"issue":"1","key":"5119_CR17","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0149-7634(85)90030-2","volume":"9","author":"JN Crawley","year":"1985","unstructured":"Crawley JN (1985) Exploratory behavior models of anxiety in mice. Neurosci Biobehav Rev 9(1):37\u201344","journal-title":"Neurosci Biobehav Rev"},{"key":"5119_CR18","doi-asserted-by":"crossref","unstructured":"Crocq MA (2015) A history of anxiety: from Hippocrates to DSM.\u00a0Dialogues Clin Neurosci 17(3):319\u2013325. https:\/\/www.tandfonline.com\/doi\/full\/10.31887\/DCNS.2015.17.3\/macrocq","DOI":"10.31887\/DCNS.2015.17.3\/macrocq"},{"key":"5119_CR19","doi-asserted-by":"publisher","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"A Daina","year":"2017","unstructured":"Daina A, Michielin O, Zoete V (2017) SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Sci Rep 7:42717","journal-title":"Sci Rep"},{"issue":"3","key":"5119_CR20","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.jep.2008.09.015","volume":"120","author":"MP De Barros","year":"2008","unstructured":"De Barros MP, Lemos M, Maistro EL, Leite MF, Sousa JPB, Bastos JK, de Andra SF (2008) Evaluation of antiulcer activity of the main phenolic acids found in Brazilian Green Propolis. J Ethnopharmacol 120(3):372\u2013377","journal-title":"J Ethnopharmacol"},{"issue":"3894","key":"5119_CR21","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1126\/science.165.3894.664","volume":"165","author":"RA Gardner","year":"1969","unstructured":"Gardner RA, Gardner BT (1969) Teaching sign language to a chimpanzee: a standardized system of gestures provides a means of two-way communication with a chimpanzee. Science 165(3894):664\u2013672","journal-title":"Science"},{"key":"5119_CR22","doi-asserted-by":"crossref","unstructured":"Gould TD, Dao DT, Kovacsics CE (2009) The open field test. Mood and anxiety related phenotypes in mice: Characterization using behavioral tests 1\u201320. https:\/\/link.springer.com\/protocol\/10.1007\/978-1-60761-303-9_1","DOI":"10.1007\/978-1-60761-303-9_1"},{"issue":"1","key":"5119_CR23","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1038\/s41598-023-28226-7","volume":"13","author":"MA Ibrahim","year":"2023","unstructured":"Ibrahim MA, Abdeljawaad KA, Roshdy E, Mohamed DE, Ali TF, Gabr GA, Abdelrahman AH (2023) In silico drug discovery of SIRT2 inhibitors from natural source as anticancer agents. Sci Rep 13(1):2146","journal-title":"Sci Rep"},{"issue":"4","key":"5119_CR24","doi-asserted-by":"publisher","first-page":"73","DOI":"10.14715\/cmb\/2020.66.4.12","volume":"66","author":"MT Islam","year":"2020","unstructured":"Islam MT, Martins N, Imran M, Hameed A, Ali SW, Salehi B, Sharifi-Rad J (2020) Anxiolytic-like effects of Moringa oleifera in Swiss mice. Cell Mol Biol 66(4):73\u201377","journal-title":"Cell Mol Biol"},{"issue":"21","key":"5119_CR25","doi-asserted-by":"publisher","first-page":"7149","DOI":"10.3390\/molecules27217149","volume":"27","author":"MS Islam","year":"2022","unstructured":"Islam MS, Hossain R, Ahmed T, Rahaman MM, Al-Khafaji K, Khan RA, Islam MT (2022) Anxiolytic-like effect of quercetin possibly through GABA receptor interaction pathway: in vivo and in silico studies. Molecules 27(21):7149","journal-title":"Molecules"},{"key":"5119_CR26","doi-asserted-by":"crossref","unstructured":"Islam MT, Prottay AAS, Akbor MS, Bhuia MS, Islam MA, Saifiuzzaman M (2024) Anxiolytic-like effect of daidzin possibly through GABAA receptor \u03b12 and \u03b13 subunits interaction pathway: in vivo and in silico studies. Pharmacological Research-Natural Products 5:100090","DOI":"10.1016\/j.prenap.2024.100090"},{"key":"5119_CR27","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.saa.2013.06.110","volume":"115","author":"I Kili\u00e7","year":"2013","unstructured":"Kili\u00e7 I, Ye\u015filo\u011flu Y (2013) Spectroscopic studies on the antioxidant activity of p- coumaric acid. Spectrochim Acta Part A Mol Biomol Spectrosc 115:719\u2013724","journal-title":"Spectrochim Acta Part A Mol Biomol Spectrosc"},{"key":"5119_CR28","doi-asserted-by":"crossref","unstructured":"Kraeuter AK, Guest PC, Sarnyai Z (2019) The open field test for measuring locomotor activity and anxiety like behavior. Methods Mol Biol 1916:99\u2013103. https:\/\/link.springer.com\/protocol\/10.1007\/978-1-4939-8994-2_9","DOI":"10.1007\/978-1-4939-8994-2_9"},{"key":"5119_CR29","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.lfs.2018.09.039","volume":"211","author":"Y Li","year":"2018","unstructured":"Li Y, Han J, Chen Y, Chen C, Chu B, Zhang Y (2018) P-coumaric acid as a prophylactic measure against normobaric hypoxia induced pulmonary edema in mice. Life Sci 211:215\u2013223","journal-title":"Life Sci"},{"key":"5119_CR30","doi-asserted-by":"publisher","first-page":"113285","DOI":"10.1016\/j.jep.2020.113285","volume":"264","author":"YS Lin","year":"2021","unstructured":"Lin YS, Peng WH, Shih MF, Cherng JY (2021) Anxiolytic effect of an extract of Salvia miltiorrhiza Bunge (Danshen) in mice. J Ethnopharmacol 264:113285","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"5119_CR31","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1093\/bioinformatics\/btu626","volume":"31","author":"Z Liu","year":"2015","unstructured":"Liu Z, Li Y, Han L, Li J, Liu J, Zhao Z, Wang R (2015) PDB-wide collection of binding data: current status of the PDBbind database. Bioinformatics 31(3):405\u2013412","journal-title":"Bioinformatics"},{"issue":"5","key":"5119_CR32","doi-asserted-by":"publisher","first-page":"893","DOI":"10.5665\/sleep.3654","volume":"37","author":"DJ Meyerhoff","year":"2014","unstructured":"Meyerhoff DJ, Mon A, Metzler T, Neylan TC (2014) Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality. Sleep 37(5):893\u2013900","journal-title":"Sleep"},{"key":"5119_CR33","doi-asserted-by":"publisher","unstructured":"Munshi MH, Yana NT, Rakib IH, Mia E, Tohfa NJ, Al Hasan MS, Sayeed MA, Akter MS, Hossain MA, Islam MT, Bhuia MS, Ansari MA (2025) Combining anxiolytic activity of thymol and trans-ferulic acid: a potential GABAergic intervention. Naunyn-Schmiedeberg\u2019s Arch Pharmacol. https:\/\/doi.org\/10.1007\/s00210-025-04858-6.Advanceonlinepublication.doi:10.1007\/s00210-025-04858-6","DOI":"10.1007\/s00210-025-04858-6.Advanceonlinepublication.doi:10.1007\/s00210-025-04858-6"},{"issue":"1","key":"5119_CR34","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1146\/annurev.pa.22.040182.001333","volume":"22","author":"RW Olsen","year":"1982","unstructured":"Olsen RW (1982) Drug interactions at the GABA receptor-ionophore complex. Annu Rev Pharmacol Toxicol 22(1):245\u2013277","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"9","key":"5119_CR35","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1038\/aps.2012.109","volume":"33","author":"SS Ou-Yang","year":"2012","unstructured":"Ou-Yang SS, Lu JY, Kong XQ, Liang ZJ, Luo C, Jiang H (2012) Computational drug discovery. Acta Pharmacol Sin 33(9):1131\u20131140","journal-title":"Acta Pharmacol Sin"},{"key":"5119_CR36","unstructured":"Palmer CM (2022) Brain energy: A revolutionary breakthrough in understanding mental health--and improving treatment for anxiety, depression, OCD, PTSD, and more. BenBella Books.\u00a0https:\/\/brainenergy.com\/"},{"issue":"6","key":"5119_CR37","first-page":"633","volume":"10","author":"F Parvizi","year":"2020","unstructured":"Parvizi F, Yaghmaei P, Rohani SAH, Mard SA (2020) Hepatoprotective properties of p-coumaric acid in a rat model of ischemia-reperfusion. Avicenna J Phytomed 10(6):633","journal-title":"Avicenna J Phytomed"},{"issue":"9","key":"5119_CR38","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.1002\/jsfa.7578","volume":"96","author":"K Pei","year":"2016","unstructured":"Pei K, Ou J, Huang J, Ou S (2016) P-coumaric acid and its conjugates: dietary sources, pharmacokinetic properties and biological activities. J Sci Food Agric 96(9):2952\u20132962","journal-title":"J Sci Food Agric"},{"issue":"9","key":"5119_CR39","doi-asserted-by":"publisher","first-page":"4066","DOI":"10.1021\/acs.jmedchem.5b00104","volume":"58","author":"DE Pires","year":"2015","unstructured":"Pires DE, Blundell TL, Ascher DB (2015) pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures. J Med Chem 58(9):4066\u20134072","journal-title":"J Med Chem"},{"issue":"3","key":"5119_CR40","doi-asserted-by":"publisher","first-page":"e23668","DOI":"10.1002\/jbt.23668","volume":"38","author":"SMP Ponnian","year":"2024","unstructured":"Ponnian SMP, Stanely SP, Roy AJ (2024) Cardioprotective effects of p\u2010coumaric acid on tachycardia, inflammation, ion pump dysfunction, and electrolyte imbalance in isoproterenol\u2010induced experimental myocardial infarction. J Biochem Mol Toxicol 38(3):e23668","journal-title":"J Biochem Mol Toxicol"},{"key":"5119_CR41","unstructured":"Reddy DS (2003) Pharmacology of endogenous neuroactive steroids. Crit Rev Neurobiol 15(3\u20134). https:\/\/www.dl.begellhouse.com\/journals\/7b004699754c9fe6,120884550b58eaad,1d1d001a28da2d16.html"},{"key":"5119_CR42","doi-asserted-by":"publisher","unstructured":"Richards G, Schock P, Haefely W (1991) Benzodiazepine receptors: New vistas. In Seminars in Neuroscience 3(3):191\u2013203. https:\/\/doi.org\/10.1016\/1044-5765(91)90016-H","DOI":"10.1016\/1044-5765(91)90016-H"},{"key":"5119_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.103884","volume":"68","author":"S Sahoo","year":"2020","unstructured":"Sahoo S, Brijesh S (2020) Anxiolytic activity of Coriandrum sativum seeds aqueous extract on chronic restraint stressed mice and effect on brain neurotransmitters. J Funct Foods 68:103884","journal-title":"J Funct Foods"},{"key":"5119_CR44","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.sajb.2019.11.023","volume":"128","author":"A Saleem","year":"2020","unstructured":"Saleem A, Saleem M, Akhtar MF (2020) Antioxidant, anti-inflammatory and antiarthritic potential of Moringa oleifera Lam: an ethnomedicinal plant of Moringaceae family. S Afr J Bot 128:246\u2013256","journal-title":"S Afr J Bot"},{"issue":"1","key":"5119_CR45","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.neuropharm.2011.07.036","volume":"62","author":"G Sanacora","year":"2012","unstructured":"Sanacora G, Treccani G, Popoli M (2012) Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders. Neuropharmacology 62(1):63\u201377","journal-title":"Neuropharmacology"},{"issue":"2","key":"5119_CR46","first-page":"1183","volume":"3","author":"T Sarkar","year":"2018","unstructured":"Sarkar T (2018) Role of hesperdin, luteolin and coumaric acid in arthritis management: a review. International Journal of Physiology, Nutrition and Physical Education 3(2):1183\u20131186","journal-title":"Int J Physiol Nutr Phys Educ"},{"issue":"8","key":"5119_CR47","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1039\/b403873h","volume":"129","author":"AC Sawaya","year":"2004","unstructured":"Sawaya AC, Tomazela DM, Cunha IB, Bankova VS, Marcucci MC, Custodio AR, Eberlin MN (2004) Electrospray ionization mass spectrometry fingerprinting of propolis. Analyst 129(8):739\u2013744","journal-title":"Analyst"},{"issue":"2","key":"5119_CR48","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1002\/ptr.4968","volume":"28","author":"A Scheepens","year":"2014","unstructured":"Scheepens A, Bisson JF, Skinner M (2014) p\u2010Coumaric acid activates the GABA\u2010A receptor in vitro and is orally anxiolytic in vivo. Phytother Res 28(2):207\u2013211","journal-title":"Phytother Res"},{"issue":"1","key":"5119_CR49","doi-asserted-by":"publisher","DOI":"10.1186\/s40816-017-0056-5","volume":"3","author":"M Shahed-Al-Mahmud","year":"2017","unstructured":"Shahed-Al-Mahmud M, Lina SMM (2017) Evaluation of sedative and anxiolytic activities of methanol extract of leaves of Persicaria hydropiper in mice. Clin Phytoscience 3(1):20","journal-title":"Clin Phytoscience"},{"key":"5119_CR50","doi-asserted-by":"crossref","unstructured":"Shen Y, Song X, Li L, Sun J, Jaiswal Y, Huang J, Liu C, Yang W, Williams L, Zhang H, Guan Y (2019) Protective effects of p-coumaric acid against oxidant and hyperlipidemia-an in vitro and in vivo evaluation. Biomed Pharmacother 111:579\u2013587","DOI":"10.1016\/j.biopha.2018.12.074"},{"issue":"48","key":"5119_CR51","doi-asserted-by":"publisher","first-page":"40224","DOI":"10.1074\/jbc.R112.386664","volume":"287","author":"E Sigel","year":"2012","unstructured":"Sigel E, Steinmann ME (2012) Structure, function, and modulation of GABAA receptors. J Biol Chem 287(48):40224\u201340231","journal-title":"J Biol Chem"},{"key":"5119_CR52","doi-asserted-by":"publisher","unstructured":"Singh H, Khurana N, Bafna PA, Mazumder R, Sharma N (2025) Neuroprotective effects of p-coumaric acid against chemical-induced dementia in mice. Pharmacological Research-Modern Chinese Medicine 16:100656. https:\/\/doi.org\/10.1016\/j.prmcm.2025.100656","DOI":"10.1016\/j.prmcm.2025.100656"},{"issue":"6","key":"5119_CR53","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/S0021-5198(19)36179-7","volume":"21","author":"K Takagi","year":"1971","unstructured":"Takagi K, Watanabe M, Saito H (1971) Studies of the spontaneous movement of animals by the hole cross test; effect of 2-dimethyl-aminoethanol and its acyl esters on the central nervous system. Jpn J Pharmacol 21(6):797\u2013810","journal-title":"Jpn J Pharmacol"},{"issue":"1","key":"5119_CR54","doi-asserted-by":"publisher","first-page":"155932582211507","DOI":"10.1177\/15593258221150704","volume":"21","author":"W Tehami","year":"2023","unstructured":"Tehami W, Nani A, Khan NA, Hichami A (2023) New insights into the anticancer effects of p-coumaric acid: focus on colorectal cancer. Dose Response 21(1):15593258221150704","journal-title":"Dose Response"},{"issue":"D1","key":"5119_CR55","doi-asserted-by":"publisher","first-page":"D364","DOI":"10.1093\/nar\/gku1028","volume":"43","author":"WG Touw","year":"2015","unstructured":"Touw WG, Baakman C, Black J, Te Beek TA, Krieger E, Joosten RP, Vriend G (2015) A series of PDB-related databanks for everyday needs. Nucleic Acids Res 43(D1):D364\u2013D368","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"5119_CR56","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1021\/acs.chemrev.5b00345","volume":"116","author":"BM Upton","year":"2016","unstructured":"Upton BM, Kasko AM (2016) Strategies for the conversion of lignin to high- value polymeric materials: review and perspective. Chem Rev 116(4):2275\u20132306","journal-title":"Chem Rev"},{"issue":"4","key":"5119_CR57","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1002\/da.10065","volume":"16","author":"HU Wittchen","year":"2002","unstructured":"Wittchen HU (2002) Generalized anxiety disorder: prevalence, burden, and cost to society. Depress Anxiety 16(4):162\u2013171","journal-title":"Depress Anxiety"},{"key":"5119_CR58","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.phrs.2018.06.015","volume":"140","author":"H Wu","year":"2019","unstructured":"Wu H, Denna TH, Storkersen JN, Gerriets VA (2019) Beyond a neurotransmitter: the role of serotonin in inflammation and immunity. Pharmacol Res 140:100\u2013114","journal-title":"Pharmacol Res"},{"key":"5119_CR59","doi-asserted-by":"crossref","unstructured":"Yu XD, Zhang D, Xiao CL, Zhou Y, Li X, Wang L, ...Shu X (2022) P-coumaric acid reverses depression-like behavior and memory deficit via inhibiting AGE-RAGE-mediated neuroinflammation. Cells 11(10):1594","DOI":"10.3390\/cells11101594"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05119-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05119-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05119-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T09:04:22Z","timestamp":1781514262000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05119-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":59,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["5119"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05119-w","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]},"assertion":[{"value":"28 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}]}}