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This report aims to describe pregnancy outcomes following oral brivudine exposure and to provide the first human clinical data on brivudine use during pregnancy. Two pregnant women exposed to oral brivudine during the first and second trimesters were referred for teratological risk assessment and followed with perinatal monitoring and postnatal clinical follow-up. Both pregnancies were continued with perinatological follow-up and resulted in the delivery of healthy infants without major congenital malformations. Postnatal follow-up identified mild allergic manifestations in one child and an isolated mild delay in the personal\u2013social developmental domain in the other. These cases provide preliminary clinical data on brivudine exposure during pregnancy and contribute to the limited human data available.<\/jats:p>","DOI":"10.1007\/s00210-026-05154-7","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T02:32:50Z","timestamp":1772591570000},"page":"12771-12773","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pregnancy outcomes following oral brivudine exposure: two case studies with long-term follow-up"],"prefix":"10.1007","volume":"399","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0009-3951","authenticated-orcid":false,"given":"Nusret","family":"Uysal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baris","family":"Karadas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihal Olgac","family":"Dundar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf Cem","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"5154_CR1","volume-title":"Drugs in pregnancy and lactation: a reference guide to fetal and neonatal risk","author":"GG Briggs","year":"2021","unstructured":"Briggs GG, Towers CV, Forinash AB (2021) Drugs in pregnancy and lactation: a reference guide to fetal and neonatal risk, 12th edn. 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