{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T01:33:20Z","timestamp":1788140000840,"version":"build-2803163510"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"The Research Program of Changzhi Municipal Health Commission","award":["Project No. 202402"],"award-info":[{"award-number":["Project No. 202402"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s00210-026-05171-6","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:36:18Z","timestamp":1773977778000},"page":"13161-13178","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Targeting ZNF570 activates ferroptosis to reverse tamoxifen resistance in ER\u2009+\u2009breast cancer cells"],"prefix":"10.1007","volume":"399","author":[{"given":"Yun","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jindan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingting","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruqi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"issue":"4","key":"5171_CR1","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.ccell.2018.03.014","volume":"33","author":"AC Berger","year":"2018","unstructured":"Berger AC et al (2018) A comprehensive pan-cancer molecular study of gynecologic and breast cancers. Cancer Cell 33(4):690-705.e9","journal-title":"Cancer Cell"},{"issue":"3","key":"5171_CR2","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F et al (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74(3):229\u2013263","journal-title":"CA Cancer J Clin"},{"issue":"9","key":"5171_CR3","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","volume":"17","author":"X Chen","year":"2021","unstructured":"Chen X et al (2021a) Ferroptosis: machinery and regulation. Autophagy 17(9):2054\u20132081","journal-title":"Autophagy"},{"issue":"5","key":"5171_CR4","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","volume":"18","author":"X Chen","year":"2021","unstructured":"Chen X et al (2021b) Broadening horizons: the role of ferroptosis in cancer. Nat Rev Clin Oncol 18(5):280\u2013296","journal-title":"Nat Rev Clin Oncol"},{"issue":"2","key":"5171_CR5","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/s41419-022-04579-1","volume":"13","author":"C Chen","year":"2022","unstructured":"Chen C et al (2022) Fascin enhances the vulnerability of breast cancer to erastin-induced ferroptosis. Cell Death Dis 13(2):150","journal-title":"Cell Death Dis"},{"issue":"7","key":"5171_CR6","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adk1835","volume":"10","author":"D Dibra","year":"2024","unstructured":"Dibra D et al (2024) Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo. Sci Adv 10(7):eadk1835","journal-title":"Sci Adv"},{"issue":"5","key":"5171_CR7","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149(5):1060\u20131072","journal-title":"Cell"},{"key":"5171_CR8","doi-asserted-by":"publisher","unstructured":"Early Breast Cancer Trialists\u2019 Collaborative Group (EBCTCG) (2005) Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 365(9472):1687\u20131717. https:\/\/doi.org\/10.1016\/S0140-6736(05)66544-0","DOI":"10.1016\/S0140-6736(05)66544-0"},{"key":"5171_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.949863","volume":"13","author":"J Hou","year":"2022","unstructured":"Hou J et al (2022) ACSL4 as a potential target and biomarker for anticancer: from molecular mechanisms to clinical therapeutics. Front Pharmacol 13:949863","journal-title":"Front Pharmacol"},{"issue":"5","key":"5171_CR10","first-page":"480","volume":"73","author":"LA Huppert","year":"2023","unstructured":"Huppert LA et al (2023) Systemic therapy for hormone receptor-positive\/human epidermal growth factor receptor 2-negative early stage and metastatic breast cancer. CA Cancer J Clin 73(5):480\u2013515","journal-title":"CA Cancer J Clin"},{"issue":"7","key":"5171_CR11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101423","volume":"9","author":"M Jain","year":"2014","unstructured":"Jain M et al (2014) ZNF367 inhibits cancer progression and is targeted by miR-195. PLoS ONE 9(7):e101423","journal-title":"PLoS ONE"},{"key":"5171_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2025.110696","volume":"281","author":"JE Kim","year":"2025","unstructured":"Kim JE, Wang SH, Lee DS (2025) P2X7R-NF-\u03baB-PDI signal pathway regulates LPS-induced impaired GSH synthesis by modulating ATF4-mediated xCT upregulation, S-nitrosylation of ASCT2 and GSHS expressions in the mouse hippocampus. Neuropharmacology 281:110696","journal-title":"Neuropharmacology"},{"issue":"8","key":"5171_CR13","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","volume":"12","author":"P Koppula","year":"2021","unstructured":"Koppula P, Zhuang L, Gan B (2021) Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell 12(8):599\u2013620","journal-title":"Protein Cell"},{"issue":"2","key":"5171_CR14","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s12282-020-01166-0","volume":"28","author":"K Kumari","year":"2021","unstructured":"Kumari K et al (2021) EZH2 knockdown in tamoxifen-resistant MCF-7 cells unravels novel targets for regaining sensitivity towards tamoxifen. Breast Cancer 28(2):355\u2013367","journal-title":"Breast Cancer"},{"issue":"1","key":"5171_CR15","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0959-440X(00)00167-6","volume":"11","author":"JH Laity","year":"2001","unstructured":"Laity JH, Lee BM, Wright PE (2001) Zinc finger proteins: new insights into structural and functional diversity. Curr Opin Struct Biol 11(1):39\u201346","journal-title":"Curr Opin Struct Biol"},{"issue":"7","key":"5171_CR16","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/s41419-023-06006-5","volume":"14","author":"Z Li","year":"2023","unstructured":"Li Z et al (2023) circRNA-SFMBT2 orchestrates ER\u03b1 activation to drive tamoxifen resistance in breast cancer cells. Cell Death Dis 14(7):482","journal-title":"Cell Death Dis"},{"issue":"1","key":"5171_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.553","volume":"6","author":"L Liu","year":"2015","unstructured":"Liu L et al (2015) Tamoxifen reduces fat mass by boosting reactive oxygen species. Cell Death Dis 6(1):e1586","journal-title":"Cell Death Dis"},{"issue":"2","key":"5171_CR18","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.cell.2018.02.052","volume":"173","author":"J Liu","year":"2018","unstructured":"Liu J et al (2018) An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics. Cell 173(2):400-416.e11","journal-title":"Cell"},{"issue":"10","key":"5171_CR19","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1007\/s00726-023-03316-y","volume":"55","author":"D Liu","year":"2023","unstructured":"Liu D et al (2023) Participation of protein metabolism in cancer progression and its potential targeting for the management of cancer. Amino Acids 55(10):1223\u20131246","journal-title":"Amino Acids"},{"issue":"7","key":"5171_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.208","volume":"7","author":"S Ma","year":"2016","unstructured":"Ma S et al (2016) Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells. Cell Death Dis 7(7):e2307","journal-title":"Cell Death Dis"},{"issue":"6","key":"5171_CR21","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1007\/s40291-025-00811-8","volume":"29","author":"S Martella","year":"2025","unstructured":"Martella S et al (2025) Evolutionary overview and future perspectives: ESR1 mutations, liquid biopsy, and artificial intelligence for a new era of personalized medicine in ER+ breast cancer. Mol Diagn Ther 29(6):773\u2013787","journal-title":"Mol Diagn Ther"},{"key":"5171_CR22","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.coph.2018.04.009","volume":"41","author":"JN Mills","year":"2018","unstructured":"Mills JN, Rutkovsky AC, Giordano A (2018) Mechanisms of resistance in estrogen receptor positive breast cancer: overcoming resistance to tamoxifen\/aromatase inhibitors. Curr Opin Pharmacol 41:59\u201365","journal-title":"Curr Opin Pharmacol"},{"key":"5171_CR23","doi-asserted-by":"crossref","unstructured":"Saatci O et al (2023) Targeting LINC00152 activates cAMP\/Ca(2+)\/ferroptosis axis and overcomes tamoxifen resistance in ER+ breast cancer. bioRxiv","DOI":"10.1038\/s41419-024-06814-3"},{"issue":"6","key":"5171_CR24","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1038\/s41419-024-06814-3","volume":"15","author":"O Saatci","year":"2024","unstructured":"Saatci O et al (2024) Targeting LINC00152 activates cAMP\/Ca(2+)\/ferroptosis axis and overcomes tamoxifen resistance in ER+ breast cancer. Cell Death Dis 15(6):418","journal-title":"Cell Death Dis"},{"key":"5171_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1563353","volume":"13","author":"Y Shang","year":"2025","unstructured":"Shang Y et al (2025) Estrogen-induced FXR1 promotes endocrine resistance and bone metastasis in breast cancer via BCL2 and GPX4. Front Cell Dev Biol 13:1563353","journal-title":"Front Cell Dev Biol"},{"key":"5171_CR26","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s13148-017-0392-9","volume":"9","author":"S Shen","year":"2017","unstructured":"Shen S et al (2017) Seven-CpG-based prognostic signature coupled with gene expression predicts survival of oral squamous cell carcinoma. Clin Epigenetics 9:88","journal-title":"Clin Epigenetics"},{"issue":"1","key":"5171_CR27","first-page":"10","volume":"75","author":"RL Siegel","year":"2025","unstructured":"Siegel RL et al (2025) Cancer statistics, 2025. CA Cancer J Clin 75(1):10\u201345","journal-title":"CA Cancer J Clin"},{"issue":"2","key":"5171_CR28","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","volume":"31","author":"D Tang","year":"2021","unstructured":"Tang D et al (2021) Ferroptosis: molecular mechanisms and health implications. Cell Res 31(2):107\u2013125","journal-title":"Cell Res"},{"key":"5171_CR29","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.freeradbiomed.2019.09.004","volume":"143","author":"V Tomkov\u00e1","year":"2019","unstructured":"Tomkov\u00e1 V et al (2019) Mitochondrial fragmentation, elevated mitochondrial superoxide and respiratory supercomplexes disassembly is connected with the tamoxifen-resistant phenotype of breast cancer cells. Free Radic Biol Med 143:510\u2013521","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"5171_CR30","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/nrg2538","volume":"10","author":"JM Vaquerizas","year":"2009","unstructured":"Vaquerizas JM et al (2009) A census of human transcription factors: function, expression and evolution. Nat Rev Genet 10(4):252\u2013263","journal-title":"Nat Rev Genet"},{"issue":"7664","key":"5171_CR31","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nature23007","volume":"547","author":"VS Viswanathan","year":"2017","unstructured":"Viswanathan VS et al (2017) Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature 547(7664):453\u2013457","journal-title":"Nature"},{"issue":"4","key":"5171_CR32","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/nbt.3772","volume":"35","author":"J Vivian","year":"2017","unstructured":"Vivian J et al (2017) Toil enables reproducible, open source, big biomedical data analyses. Nat Biotechnol 35(4):314\u2013316","journal-title":"Nat Biotechnol"},{"issue":"5","key":"5171_CR33","doi-asserted-by":"publisher","first-page":"5677","DOI":"10.18632\/oncotarget.6801","volume":"7","author":"H Wang","year":"2016","unstructured":"Wang H et al (2016) Kaiso, a transcriptional repressor, promotes cell migration and invasion of prostate cancer cells through regulation of miR-31 expression. Oncotarget 7(5):5677\u20135689","journal-title":"Oncotarget"},{"key":"5171_CR34","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.jare.2024.10.026","volume":"75","author":"X Wang","year":"2025","unstructured":"Wang X et al (2025) Multiple roles of p53 in cancer development: regulation of tumor microenvironment, m(6)A modification and diverse cell death mechanisms. J Adv Res 75:539\u2013560","journal-title":"J Adv Res"},{"issue":"12","key":"5171_CR35","doi-asserted-by":"publisher","first-page":"2568","DOI":"10.1038\/s41388-020-1166-y","volume":"39","author":"X Wu","year":"2020","unstructured":"Wu X et al (2020) Zinc finger protein 367 promotes metastasis by inhibiting the Hippo pathway in breast cancer. Oncogene 39(12):2568\u20132582","journal-title":"Oncogene"},{"issue":"10","key":"5171_CR36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110990","volume":"9","author":"Y Xiao","year":"2014","unstructured":"Xiao Y et al (2014) Zinc-finger protein 545 inhibits cell proliferation as a tumor suppressor through inducing apoptosis and is disrupted by promoter methylation in breast cancer. PLoS ONE 9(10):e110990","journal-title":"PLoS ONE"},{"issue":"3","key":"5171_CR37","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/cdd.2015.158","volume":"23","author":"Y Xie","year":"2016","unstructured":"Xie Y et al (2016) Ferroptosis: process and function. Cell Death Differ 23(3):369\u2013379","journal-title":"Cell Death Differ"},{"key":"5171_CR38","doi-asserted-by":"crossref","unstructured":"Xu Y et al (2025)\u00a0H3K18la-driven methyltransferase 1-mediated upregulation of NeuroD1 m7G modification in promoting ferroptosis resistance in rheumatoid arthritis synovial fibroblasts. Int J Biol Macromol 149196","DOI":"10.1016\/j.ijbiomac.2025.149196"},{"key":"5171_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102952","volume":"68","author":"Z Xu","year":"2023","unstructured":"Xu Z et al (2023) RelB-activated GPX4 inhibits ferroptosis and confers tamoxifen resistance in breast cancer. Redox Biol 68:102952","journal-title":"Redox Biol"},{"issue":"8","key":"5171_CR40","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1080\/15548627.2023.2200554","volume":"19","author":"Q Xue","year":"2023","unstructured":"Xue Q et al (2023) Copper metabolism in cell death and autophagy. Autophagy 19(8):2175\u20132195","journal-title":"Autophagy"},{"issue":"11","key":"5171_CR41","doi-asserted-by":"publisher","first-page":"4321","DOI":"10.1158\/0008-5472.CAN-08-0407","volume":"68","author":"L Yang","year":"2008","unstructured":"Yang L et al (2008) The previously undescribed ZKSCAN3 (ZNF306) is a novel \u201cdriver\u201d of colorectal cancer progression. Cancer Res 68(11):4321\u20134330","journal-title":"Cancer Res"},{"issue":"1-2","key":"5171_CR42","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","volume":"156","author":"WS Yang","year":"2014","unstructured":"Yang WS et al (2014) Regulation of ferroptotic cancer cell death by GPX4. Cell 156(1\u20132):317\u2013331","journal-title":"Cell"},{"issue":"5","key":"5171_CR43","first-page":"5591","volume":"14","author":"H Yang","year":"2017","unstructured":"Yang H et al (2017) Overexpression of tumor suppressor gene ZNF750 inhibits oral squamous cell carcinoma metastasis. Oncol Lett 14(5):5591\u20135596","journal-title":"Oncol Lett"},{"key":"5171_CR44","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.638751","volume":"11","author":"H Yang","year":"2021","unstructured":"Yang H et al (2021) ZNF213 facilitates ER alpha signaling in breast cancer cells. Front Oncol 11:638751","journal-title":"Front Oncol"},{"key":"5171_CR45","doi-asserted-by":"publisher","DOI":"10.1172\/JCI183531","author":"SY Yang","year":"2025","unstructured":"Yang SY et al (2025a) Kinesin-like protein KIFC2 stabilizes CDK4 to accelerate growth and confer resistance in HR+\/HER2- breast cancer. J Clin Invest. https:\/\/doi.org\/10.1172\/JCI183531","journal-title":"J Clin Invest"},{"issue":"1","key":"5171_CR46","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202402553RR","volume":"39","author":"J Yang","year":"2025","unstructured":"Yang J et al (2025b) Prolonged tamoxifen treatment induces iron deposition and ferroptosis in the liver. FASEB J 39(1):e70313","journal-title":"FASEB J"},{"issue":"6","key":"5171_CR47","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.4103\/jcrt.jcrt_608_23","volume":"19","author":"L Ye","year":"2023","unstructured":"Ye L et al (2023) Tamoxifen induces ferroptosis in MCF-7 organoid. J Cancer Res Ther 19(6):1627\u20131635","journal-title":"J Cancer Res Ther"},{"issue":"1","key":"5171_CR48","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1186\/s12967-024-05714-6","volume":"22","author":"H Ye","year":"2024","unstructured":"Ye H et al (2024) KLF14 directly downregulates the expression of GPX4 to exert antitumor effects by promoting ferroptosis in cervical cancer. J Transl Med 22(1):923","journal-title":"J Transl Med"},{"key":"5171_CR49","doi-asserted-by":"publisher","DOI":"10.3390\/genes15101316","author":"P Zhang","year":"2024","unstructured":"Zhang P et al (2024) PRODH regulates tamoxifen resistance through ferroptosis in breast cancer cells. Genes. https:\/\/doi.org\/10.3390\/genes15101316","journal-title":"Genes"},{"key":"5171_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157548","volume":"149","author":"C Zhou","year":"2025","unstructured":"Zhou C et al (2025a) Tanshinone IIA attenuates cerebral-ischemia-reperfusion-induced neuroinflammation by inhibiting the TLR4\/NF-\u03baB signaling cascade: a study integrating network pharmacology, bioinformatics, and experimental validation. Phytomedicine 149:157548","journal-title":"Phytomedicine"},{"key":"5171_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2025.156154","volume":"274","author":"Q Zhou","year":"2025","unstructured":"Zhou Q et al (2025b) ZEB1-upregulated LCN2 via transcription regulation affects ferroptosis and malignant progression in non-small cell lung cancer. Pathol Res Pract 274:156154","journal-title":"Pathol Res Pract"},{"issue":"1","key":"5171_CR52","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1038\/s41467-019-10352-4","volume":"10","author":"Y Zhu","year":"2019","unstructured":"Zhu Y et al (2019) Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter. Nat Commun 10(1):2399","journal-title":"Nat Commun"},{"key":"5171_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.118303","volume":"299","author":"F Zhu","year":"2025","unstructured":"Zhu F et al (2025a) ATF4 participates in perfluorooctane sulfonate-induced neurotoxicity by regulating ferroptosis. Ecotoxicol Environ Saf 299:118303","journal-title":"Ecotoxicol Environ Saf"},{"issue":"1","key":"5171_CR54","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s13578-025-01433-7","volume":"15","author":"J Zhu","year":"2025","unstructured":"Zhu J et al (2025b) ZNF146 accelerates lung adenocarcinoma progression through MDM2\/p53 and PHGDH\/ferroptosis. Cell Biosci 15(1):94","journal-title":"Cell Biosci"},{"issue":"6","key":"5171_CR55","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.32604\/or.2024.047257","volume":"32","author":"Z Zhuo","year":"2024","unstructured":"Zhuo Z et al (2024) Reversal of tamoxifen resistance by artemisinin in ER+ breast cancer: bioinformatics analysis and experimental validation. Oncol Res 32(6):1093\u20131107","journal-title":"Oncol Res"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05171-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05171-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05171-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T03:43:22Z","timestamp":1783914202000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05171-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,20]]},"references-count":55,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["5171"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05171-6","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,20]]},"assertion":[{"value":"19 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.The authors declare no competing interests","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This clinical study, animal study, and their respective research protocols have all been approved by the Clinical Research Ethics Committee of Changzhi People\u2019s Hospital Affiliated to Changzhi Medical College (Approval No.: 2024\u20132024167). Additionally, these protocols comply with the requirements of the IACUC Handbook (3rd Edition) (Institutional Animal Care and Use Committee Handbook) and the ARRIVE Guidelines (Animal Research: Reporting of In Vivo Experiments Guidelines).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}