{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:13:32Z","timestamp":1791893612994,"version":"4.3.4"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Natural Science Foundation of Science and Technology Department of Shaanxi Province of China","award":["2024JC-ZDXM-56"],"award-info":[{"award-number":["2024JC-ZDXM-56"]}]},{"name":"Natural Science Foundation of Science and Technology Department of Shaanxi Province of China","award":["2021JZ-46"],"award-info":[{"award-number":["2021JZ-46"]}]},{"name":"Shaanxi Fundamental Science Research Project for Chemistry and Biology","award":["23JHQ045"],"award-info":[{"award-number":["23JHQ045"]}]},{"name":"Shaanxi Fundamental Science Research Project for Chemistry and Biology","award":["23JHQ049"],"award-info":[{"award-number":["23JHQ049"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81773870"],"award-info":[{"award-number":["81773870"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s00210-026-05218-8","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T04:34:05Z","timestamp":1773894845000},"page":"12709-12722","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dauricine ameliorates intestinal inflammation and oxidative stress in DSS-induced colitis through TLR4\/NLRP3\/GSDMD-mediated pyroptosis and Nrf2 pathway"],"prefix":"10.1007","volume":"399","author":[{"given":"Lin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daili","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"issue":"1","key":"5218_CR1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02285-4","volume":"22","author":"C Abad","year":"2024","unstructured":"Abad C, Demeules M, Guillou C, Gond\u00e9 H, Zoubairi R, Tan YV, Pinto-Espinoza C, Sch\u00e4fer W, Mann AM, Vouret-Craviari V, Koch-Nolte F, Adriouch S (2024) Administration of an AAV vector coding for a P2X7-blocking nanobody-based biologic ameliorates colitis in mice. J Nanobiotechnol 22(1):27. https:\/\/doi.org\/10.1186\/s12951-023-02285-4","journal-title":"J Nanobiotechnol"},{"key":"5218_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2025.107192","volume":"212","author":"RS Almalki","year":"2025","unstructured":"Almalki RS, Gazzaz M, Miski SF, Fayed HM, Mohamed BMSA, Hessin AF, Afifi SM, Esatbeyoglu T, Korany RMS, Elbaset MA (2025) Repositioning gemigliptin for the alleviation of thioacetamide-induced liver fibrosis in rats: targeting TLR4\/MAPK, SIRT1\/AMPK\/Nrf2, PI3K\/AKT\/mTOR axis and apoptosis. Eur J Pharm Sci 212:107192. https:\/\/doi.org\/10.1016\/j.ejps.2025.107192","journal-title":"Eur J Pharm Sci"},{"issue":"2","key":"5218_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/biology11020303","volume":"11","author":"IA Alsharif","year":"2022","unstructured":"Alsharif IA, Fayed HM, Abdel-Rahman RF, Abd-Elsalam RM, Ogaly HA (2022) Miconazole mitigates acetic acid-induced experimental colitis in rats: insight into inflammation, oxidative stress and Keap1\/Nrf-2 signaling crosstalk. Biology 11(2):303. https:\/\/doi.org\/10.3390\/biology11020303","journal-title":"Biology"},{"issue":"1","key":"5218_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-015-0073-6","volume":"6","author":"A Banerjee","year":"2015","unstructured":"Banerjee A, Bizzaro D, Burra P, Di Liddo R, Pathak S, Arcidiacono D, Cappon A, Bo P, Conconi MT, Crescenzi M, Pinna CMA, Parnigotto PP, Alison MR, Sturniolo GC, D\u2019Inc\u00e0 R, Russo FP (2015) Umbilical cord mesenchymal stem cells modulate dextran sulfate sodium induced acute colitis in immunodeficient mice. Stem Cell Res Ther 6(1):79. https:\/\/doi.org\/10.1186\/s13287-015-0073-6","journal-title":"Stem Cell Res Ther"},{"key":"5218_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115570","volume":"298","author":"ZH Bian","year":"2022","unstructured":"Bian ZH, Qin YW, Li L, Su LL, Fei CH, Li Y, Hu MM, Chen XW, Zhang W, Mao CQ, Yuan XH, Lu TL, Ji D (2022) Schisandra chinensis (Turcz.) Baill. protects against DSS-induced colitis in mice: involvement of TLR4\/NF-\u03baB\/NLRP3 inflammasome pathway and gut microbiota. J Ethnopharmacol 298:115570. https:\/\/doi.org\/10.1016\/j.jep.2022.115570","journal-title":"J Ethnopharmacol"},{"issue":"4","key":"5218_CR6","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/S2468-1253(17)30004-3","volume":"2","author":"S Bopanna","year":"2017","unstructured":"Bopanna S, Ananthakrishnan AN, Kedia S, Yajnik V, Ahuja V (2017) Risk of colorectal cancer in Asian patients with ulcerative colitis: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol 2(4):269\u2013276. https:\/\/doi.org\/10.1016\/S2468-1253(17)30004-3","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"27","key":"5218_CR7","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1056\/NEJMra2002697","volume":"383","author":"JT Chang","year":"2020","unstructured":"Chang JT (2020) Pathophysiology of inflammatory bowel diseases. N Engl J Med 383(27):2652\u20132664. https:\/\/doi.org\/10.1056\/NEJMra2002697","journal-title":"N Engl J Med"},{"key":"5218_CR8","doi-asserted-by":"publisher","first-page":"4371","DOI":"10.2147\/DDDT.S471352","volume":"18","author":"KQ Chen","year":"2024","unstructured":"Chen KQ, Wang SZ, Lei HB, Liu X (2024) Dauricine: review of pharmacological activity. Drug Des Devel Ther 18:4371\u20134385. https:\/\/doi.org\/10.2147\/DDDT.S471352","journal-title":"Drug Des Devel Ther"},{"issue":"3","key":"5218_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/nu11030516","volume":"11","author":"IC Chung","year":"2019","unstructured":"Chung IC, OuYang CN, Yuan SN, Lin HC, Huang KY, Wu PS, Liu CY, Tsai KJ, Loi LK, Chen YJ, Chung AK, Ojcius DM, Chang YS, Chen LC (2019) Pretreatment with a heat-killed probiotic modulates the NLRP3 inflammasome and attenuates colitis-associated colorectal cancer in mice. Nutrients 11(3):516. https:\/\/doi.org\/10.3390\/nu11030516","journal-title":"Nutrients"},{"issue":"1","key":"5218_CR10","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.intimp.2014.09.005","volume":"23","author":"L Cui","year":"2014","unstructured":"Cui L, Feng L, Zhang ZH, Xiao BJ (2014) The anti-inflammation effect of baicalin on experimental colitis through inhibiting TLR4\/NF-\u03baB pathway activation. Int Immunopharmacol 23(1):294\u2013303. https:\/\/doi.org\/10.1016\/j.intimp.2014.09.005","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"5218_CR11","doi-asserted-by":"publisher","first-page":"332","DOI":"10.4161\/gmic.20228","volume":"3","author":"CO Elson","year":"2012","unstructured":"Elson CO, Cong Y (2012) Host-microbiota interactions in inflammatory bowel disease. Gut Microbes 3(4):332\u2013344. https:\/\/doi.org\/10.4161\/gmic.20228","journal-title":"Gut Microbes"},{"key":"5218_CR12","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","volume":"41","author":"J Fu","year":"2023","unstructured":"Fu J, Wu H (2023) Structural mechanisms of NLRP3 inflammasome assembly and activation. Annu Rev Immunol 41:301\u2013316. https:\/\/doi.org\/10.1146\/annurev-immunol-081022-021207","journal-title":"Annu Rev Immunol"},{"issue":"9","key":"5218_CR13","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/j.freeradbiomed.2010.01.006","volume":"48","author":"R Gill","year":"2010","unstructured":"Gill R, Tsung A, Billiar T (2010) Linking oxidative stress to inflammation: toll-like receptors. Free Radic Biol Med 48(9):1121\u20131132. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2010.01.006","journal-title":"Free Radic Biol Med"},{"key":"5218_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116221","volume":"307","author":"DX Gu","year":"2023","unstructured":"Gu DX, Wang HT, Yan MG, Li YX, Yang SJ, Shi DY, Guo SN, Wu L, Liu C (2023) Echinacea purpurea (L.) Moench extract suppresses inflammation by inhibition of C3a\/C3aR signaling pathway in TNBS-induced ulcerative colitis rats. J Ethnopharmacol 307:116221. https:\/\/doi.org\/10.1016\/j.jep.2023.116221","journal-title":"J Ethnopharmacol"},{"key":"5218_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-12-86","volume":"12","author":"B Hoesel","year":"2013","unstructured":"Hoesel B, Schmid JA (2013) The complexity of NF-\u03baB signaling in inflammation and cancer. Mol Cancer 12:86. https:\/\/doi.org\/10.1186\/1476-4598-12-86","journal-title":"Mol Cancer"},{"issue":"7","key":"5218_CR16","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1038\/s41590-020-0669-6","volume":"21","author":"JJ Hu","year":"2020","unstructured":"Hu JJ, Liu X, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth LR, Magupalli VG, Zhao L, Luo HR, Kim J, Lieberman J, Wu H (2020) FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nat Immunol 21(7):736\u2013745. https:\/\/doi.org\/10.1038\/s41590-020-0669-6","journal-title":"Nat Immunol"},{"issue":"9","key":"5218_CR17","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","volume":"18","author":"Y Huang","year":"2021","unstructured":"Huang Y, Xu W, Zhou RB (2021) Nlrp3 inflammasome activation and cell death. Cell Mol Immunol 18(9):2114\u20132127. https:\/\/doi.org\/10.1038\/s41423-021-00740-6","journal-title":"Cell Mol Immunol"},{"issue":"1","key":"5218_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16043-9","volume":"11","author":"M Karmakar","year":"2020","unstructured":"Karmakar M, Minns M, Greenberg EN, Diaz-Aponte J, Pestonjamasp K, Johnson JL, Rathkey JK, Abbott DW, Wang K, Shao F, Catz SD, Dubyak GR, Pearlman E (2020) <article-title update=\"added\">N-GSDMD trafficking to neutrophil organelles facilitates IL-1\u03b2 release independently of plasma membrane pores and pyroptosis. Nat Commun 11(1):2212. https:\/\/doi.org\/10.1038\/s41467-020-16043-9","journal-title":"Nat Commun"},{"issue":"3","key":"5218_CR19","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1159\/000468988","volume":"26","author":"I Khan","year":"2017","unstructured":"Khan I, Samson SE, Grover AK (2017) Antioxidant supplements and gastrointestinal diseases: a critical appraisal. Med Princ Pract 26(3):201\u2013217. https:\/\/doi.org\/10.1159\/000468988","journal-title":"Med Princ Pract"},{"key":"5218_CR20","doi-asserted-by":"publisher","first-page":"6044","DOI":"10.12659\/MSM.908529","volume":"24","author":"Q Lei","year":"2018","unstructured":"Lei Q, Yi T, Chen C (2018) NF-\u03baB-Gasdermin D (GSDMD) axis couples oxidative stress and NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome-mediated cardiomyocyte pyroptosis following myocardial infarction. Med Sci Monit 24:6044\u20136052. https:\/\/doi.org\/10.12659\/MSM.908529","journal-title":"Med Sci Monit"},{"key":"5218_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113445","volume":"267","author":"HB Li","year":"2021","unstructured":"Li HB, Chen XH, Liu JY, Chen MY, Huang M, Huang GX, Chen XL, Du Q, Su JY, Lin RF (2021) Ethanol extract of Centella asiatica alleviated dextran sulfate sodium-induced colitis: restoration on mucosa barrier and gut microbiota homeostasis. J Ethnopharmacol 267:113445. https:\/\/doi.org\/10.1016\/j.jep.2020.113445","journal-title":"J Ethnopharmacol"},{"key":"5218_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.111214","volume":"126","author":"YX Li","year":"2024","unstructured":"Li YX, Lv L, Li SL, Qian HH (2024) Gentianine alleviates dextran sulfate sodium-induced ulcerative colitis via inhibition of TLR4\/NLRP3-mediated pyroptosis. Int Immunopharmacol 126:111214. https:\/\/doi.org\/10.1016\/j.intimp.2023.111214","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"5218_CR23","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1089\/ars.2015.6615","volume":"26","author":"XT Liu","year":"2017","unstructured":"Liu XT, Zhang X, Ding Y, Zhou W, Tao L, Lu P, Wang YJ, Hu R (2017) Nuclear factor E2-related factor-2 negatively regulates NLRP3 inflammasome activity by inhibiting reactive oxygen species-induced NLRP3 priming. Antioxid Redox Signal 26(1):28\u201343. https:\/\/doi.org\/10.1089\/ars.2015.6615","journal-title":"Antioxid Redox Signal"},{"key":"5218_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155941","volume":"133","author":"M Liu","year":"2024","unstructured":"Liu M, Guan GQ, Wang YH, Lu X, Duan XQ, Xu XT (2024) p-Hydroxy benzaldehyde, a phenolic compound from Nostoc commune, ameliorates DSS-induced colitis against oxidative stress via the Nrf2\/HO-1\/NQO-1\/NF-\u03baB\/AP-1 pathway. Phytomedicine 133:155941. https:\/\/doi.org\/10.1016\/j.phymed.2024.155941","journal-title":"Phytomedicine"},{"issue":"2","key":"5218_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118879","volume":"337","author":"JJ Liu","year":"2025","unstructured":"Liu JJ, Wei F, Liu J, Sun WB, Liu SS, Chen SN, Zhang DQ, Xu BL, Ma SC (2025) Protective effects and mechanisms of HuDiChangRong capsule on TNBS-induced ulcerative colitis in mice. J Ethnopharmacol 337(2):118879. https:\/\/doi.org\/10.1016\/j.jep.2024.118879","journal-title":"J Ethnopharmacol"},{"key":"5218_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/srep26585","volume":"6","author":"MC Lu","year":"2016","unstructured":"Lu MC, Ji JA, Jiang YL, Chen ZY, Yuan ZW, You QD, Jiang ZY (2016) An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis. Sci Rep 6:26585. https:\/\/doi.org\/10.1038\/srep26585","journal-title":"Sci Rep"},{"issue":"10","key":"5218_CR27","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1055\/a-1151-5138","volume":"86","author":"L Lv","year":"2020","unstructured":"Lv L, Yin B, You Y, Sun ZY, He J, Cao YJ (2020) Protective effects of total alkaloids from Menispermum dauricum against airway inflammation in asthmatic mice. Planta Med 86(10):665\u2013673. https:\/\/doi.org\/10.1055\/a-1151-5138","journal-title":"Planta Med"},{"key":"5218_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121501","volume":"318","author":"L Lv","year":"2023","unstructured":"Lv L, Chen ZY, Bai WH, Hao JH, Heng ZG, Meng CJ, Wang L, Luo XL, Wang XM, Cao YJ, He J (2023) Taurohyodeoxycholic acid alleviates trinitrobenzene sulfonic acid induced ulcerative colitis via regulating Th1\/Th2 and Th17\/Treg cells balance. Life Sci 318:121501. https:\/\/doi.org\/10.1016\/j.lfs.2023.121501","journal-title":"Life Sci"},{"key":"5218_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113670","volume":"269","author":"TN Mahmoud","year":"2021","unstructured":"Mahmoud TN, El-Maadawy WH, Kandil ZA, Khalil H, El-Fiky NM, El Alfy TSMA (2021) Canna x generalis L.H. Bailey rhizome extract ameliorates dextran sulfate sodium-induced colitis via modulating intestinal mucosal dysfunction, oxidative stress, inflammation, and TLR4\/NF-B and NLRP3 inflammasome pathways. J Ethnopharmacol 269:113670. https:\/\/doi.org\/10.1016\/j.jep.2020.113670","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"5218_CR30","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/cr.2013.6","volume":"23","author":"KR Mao","year":"2013","unstructured":"Mao KR, Chen SZ, Chen MK, Ma YL, Wang Y, Huang B, He ZY, Zeng Y, Hu Y, Sun SH, Li J, Wu XD, Wang XR, Strober W, Chen C, Meng GX, Sun B (2013) Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. Cell Res 23(2):201\u2013212. https:\/\/doi.org\/10.1038\/cr.2013.6","journal-title":"Cell Res"},{"issue":"2","key":"5218_CR31","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/eci.12392","volume":"45","author":"S Martin-Rodriguez","year":"2015","unstructured":"Martin-Rodriguez S, Caballo C, Gutierrez G, Vera M, Cruzado JM, Cases A, Escolar G, Diaz-Ricart M (2015) TLR4 and NALP3 inflammasome in the development of endothelial dysfunction in uraemia. Eur J Clin Invest 45(2):160\u2013169. https:\/\/doi.org\/10.1111\/eci.12392","journal-title":"Eur J Clin Invest"},{"key":"5218_CR32","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02969","volume":"10","author":"Y Mei","year":"2019","unstructured":"Mei Y, Wang ZH, Zhang YF, Wan T, Xue JC, He W, Luo Y, Xu YJ, Bai X, Wang Q, Huang YJ (2019) FA-97, a new synthetic caffeic acid phenethyl ester derivative, ameliorates DSS-induced colitis against oxidative stress by activating Nrf2\/HO-1 pathway. Front Immunol 10:2969. https:\/\/doi.org\/10.3389\/fimmu.2019.02969","journal-title":"Front Immunol"},{"key":"5218_CR33","first-page":"106","volume-title":"Pharmacopoeia of the People\u2019s Republic of China (Vol. 1)","author":"National Pharmacopoeia Committee","year":"2025","unstructured":"National Pharmacopoeia Committee (2025) Pharmacopoeia of the People\u2019s Republic of China (Vol. 1). China Medical Science and Technology Publishing Press, Beijing, p 106"},{"issue":"10114","key":"5218_CR34","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","volume":"390","author":"SC Ng","year":"2017","unstructured":"Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, Panaccione R, Ghosh S, Wu JCY, Chan FKL, Sung JJY, Kaplan GG (2017) Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet 390(10114):2769\u20132778. https:\/\/doi.org\/10.1016\/S0140-6736(17)32448-0","journal-title":"Lancet"},{"issue":"5","key":"5218_CR35","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1038\/s41423-021-00670-3","volume":"18","author":"S Paik","year":"2021","unstructured":"Paik S, Kim JK, Silwal P, Sasakawa C, Jo EK (2021) An update on the regulatory mechanisms of NLRP3 inflammasome activation. Cell Mol Immunol 18(5):1141\u20131160. https:\/\/doi.org\/10.1038\/s41423-021-00670-3","journal-title":"Cell Mol Immunol"},{"issue":"11","key":"5218_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03178-2","volume":"11","author":"L Peng","year":"2020","unstructured":"Peng L, Wen L, Shi QF, Gao F, Huang B, Meng J, Hu CP, Wang CM (2020) Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-\u03baB\/NLRP3-mediated epithelial-mesenchymal transition and inflammation. Cell Death Dis 11(11):978. https:\/\/doi.org\/10.1038\/s41419-020-03178-2","journal-title":"Cell Death Dis"},{"key":"5218_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2024.106904","volume":"175","author":"JZ Peng","year":"2024","unstructured":"Peng JZ, Tang S, Huang LF, Fang Y (2024) Protective role of TRPM7 knockdown in ulcerative colitis via blocking NLRP3 inflammasome-mediated pyroptosis. Prostaglandins Other Lipid Mediat 175:106904. https:\/\/doi.org\/10.1016\/j.prostaglandins.2024.106904","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"5218_CR38","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8416763","volume":"2017","author":"G Pizzino","year":"2017","unstructured":"Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, Squadrito F, Altavilla D, Bitto A (2017) Oxidative stress: harms and benefits for human health. Oxid Med Cell Longev 2017:8416763. https:\/\/doi.org\/10.1155\/2017\/8416763","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"5218_CR39","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-025-01075-y","volume":"24","author":"LX Qin","year":"2025","unstructured":"Qin LX, Lv WL (2025) Dietary content and eating behavior in ulcerative colitis: a narrative review and future perspective. Nutr J 24(1):12. https:\/\/doi.org\/10.1186\/s12937-025-01075-y","journal-title":"Nutr J"},{"key":"5218_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2025.103085","volume":"97","author":"K Rahimi","year":"2025","unstructured":"Rahimi K, Rezaie A, Javadi A, Kalantari MK, Eftekhar N, Shushtari H (2025) The role of alpha-pinene on the NLRP3-Caspase 1 pathway in the ulcerative colitis model in rats. Tissue Cell 97:103085. https:\/\/doi.org\/10.1016\/j.tice.2025.103085","journal-title":"Tissue Cell"},{"issue":"6","key":"5218_CR41","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","volume":"140","author":"K Schroder","year":"2010","unstructured":"Schroder K, Tschopp J (2010) The inflammasomes. Cell 140(6):821\u2013832. https:\/\/doi.org\/10.1016\/j.cell.2010.01.040","journal-title":"Cell"},{"key":"5218_CR42","unstructured":"Su Q (2013) Studies on the chemical constituents and anti-ulcerative colitis activity of Menispermum dauricum. Northwest University Press, Xi\u2019an, China"},{"key":"5218_CR43","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jep.2016.07.047","volume":"193","author":"Q Su","year":"2016","unstructured":"Su Q, He J, Wang ZY, Lv L, Suo Y, Wang JJ, Zheng ZW, Huo CC, Li J (2016) Intestinal anti-inflammatory effect of the rhizome extracts of Menispermum dauricum DC. on trinitrobenzene sulfonic acid induced ulcerative colitis in mice. J Ethnopharmacol 193:12\u201320. https:\/\/doi.org\/10.1016\/j.jep.2016.07.047","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"5218_CR44","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02724-w","volume":"22","author":"SC Tang","year":"2024","unstructured":"Tang SC, Wang WC, Wang YJ, Gao YH, Dai KK, Zhang WJ, Wu XD, Yuan XD, Jin CF, Zan XJ, Zhu LM, Geng WJ (2024) Sustained release of 5-aminosalicylic acid from azoreductase-responsive polymeric prodrugs for prolonged colon-targeted colitis therapy. J Nanobiotechnol 22(1):468. https:\/\/doi.org\/10.1186\/s12951-024-02724-w","journal-title":"J Nanobiotechnol"},{"key":"5218_CR45","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.freeradbiomed.2020.11.018","volume":"163","author":"R Tocmo","year":"2021","unstructured":"Tocmo R, Le B, Heun A, van Pijkeren JP, Parkin K, Johnson JJ (2021) Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells. Free Radic Biol Med 163:102\u2013115. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2020.11.018","journal-title":"Free Radic Biol Med"},{"key":"5218_CR46","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/978-3-030-33330-0_8","volume":"1216","author":"I Uchmanowicz","year":"2020","unstructured":"Uchmanowicz I (2020) Oxidative stress, frailty and cardiovascular diseases: current evidence. Adv Exp Med Biol 1216:65\u201377. https:\/\/doi.org\/10.1007\/978-3-030-33330-0_8","journal-title":"Adv Exp Med Biol"},{"issue":"3","key":"5218_CR47","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.3390\/ijms22031271","volume":"22","author":"L Urwanisch","year":"2021","unstructured":"Urwanisch L, Luciano M, Horejs-Hoeck J (2021) The NLRP3 inflammasome and its role in the pathogenicity of leukemia. Int J Mol Sci 22(3):1271. https:\/\/doi.org\/10.3390\/ijms22031271","journal-title":"Int J Mol Sci"},{"key":"5218_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.117237","volume":"243","author":"LF Wang","year":"2020","unstructured":"Wang LF, Pu ZJ, Li MX, Wang KX, Deng LJ, Chen W (2020) Antioxidative and antiapoptosis: neuroprotective effects of dauricine in Alzheimer\u2019s disease models. Life Sci 243:117237. https:\/\/doi.org\/10.1016\/j.lfs.2019.117237","journal-title":"Life Sci"},{"key":"5218_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2025.156085","volume":"272","author":"X Wang","year":"2025","unstructured":"Wang X, Monemi M, Moghadam FM, Fazilat A, Roshani S, Valilo M (2025) The crosstalk between Nrf2 and pyroptosis in diseases. Pathol Res Pract 272:156085. https:\/\/doi.org\/10.1016\/j.prp.2025.156085","journal-title":"Pathol Res Pract"},{"issue":"9","key":"5218_CR50","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1038\/s41423-022-00905-x","volume":"19","author":"X Wei","year":"2022","unstructured":"Wei X, Xie F, Zhou X, Wu Y, Yan H, Liu T, Huang J, Wang F, Zhou F, Zhang L (2022) Role of pyroptosis in inflammation and cancer. Cell Mol Immunol 19(9):971\u2013992. https:\/\/doi.org\/10.1038\/s41423-022-00905-x","journal-title":"Cell Mol Immunol"},{"key":"5218_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2025.110212","volume":"149","author":"MX Wei","year":"2025","unstructured":"Wei MX, Wu XY, Lin JW, Huang JY, Cheng J, Huang WF, Xu GH, Yi LT (2025) Astaxanthin alleviates DSS-induced ulcerative colitis in mice associated with Nrf2-mediated ferroptosis independently of gut microbiota modulation. J Nutr Biochem 149:110212. https:\/\/doi.org\/10.1016\/j.jnutbio.2025.110212","journal-title":"J Nutr Biochem"},{"key":"5218_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117560","volume":"321","author":"GQ Xia","year":"2024","unstructured":"Xia GQ, Zhu MP, Li JW, Huang H (2024) An alkaloid from Menispermum dauricum, dauricine mediates Ca2+ influx and inhibits NF-\u03baB pathway to protect chondrocytes from IL-1\u03b2-induced inflammation and catabolism. J Ethnopharmacol 321:117560. https:\/\/doi.org\/10.1016\/j.jep.2023.117560","journal-title":"J Ethnopharmacol"},{"key":"5218_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2022.105099","volume":"94","author":"SY Xu","year":"2022","unstructured":"Xu SY, Xia TS, Zhang JW, Jiang YP, Wang NN, Xin HL (2022) Protective effects of bitter acids from Humulus lupulus L. against senile osteoporosis via activating Nrf2\/HO-1\/NQO1 pathway in D-galactose induced aging mice. J Funct Foods 94:105099. https:\/\/doi.org\/10.1016\/j.jff.2022.105099","journal-title":"J Funct Foods"},{"issue":"1","key":"5218_CR54","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2782112","volume":"2022","author":"SG Xue","year":"2022","unstructured":"Xue SG, Xue Y, Dou DB, Wu H, Zhang P, Gao Y, Tang YN, Xia ZH, Yang S, Gu S (2022) Kui jie tong ameliorates ulcerative colitis by regulating gut microbiota and NLRP3\/Caspase-1 classical pyroptosis signaling pathway. Dis Markers 2022(1):2782112. https:\/\/doi.org\/10.1155\/2022\/2782112","journal-title":"Dis Markers"},{"key":"5218_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114086","volume":"158","author":"JC Xue","year":"2023","unstructured":"Xue JC, Yuan S, Meng H, Hou XT, Li J, Zhang HM, Chen LL, Zhang CH, Zhang QG (2023) The role and mechanism of flavonoid herbal natural products in ulcerative colitis. Biomed Pharmacother 158:114086. https:\/\/doi.org\/10.1016\/j.biopha.2022.114086","journal-title":"Biomed Pharmacother"},{"key":"5218_CR56","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155415","volume":"128","author":"S Yang","year":"2024","unstructured":"Yang S, Li Y, Zheng X, Zheng X, Lin Y, Guo S, Liu C (2024) Effects of folate-chicory acid liposome on macrophage polarization and TLR4\/NF-\u03baB signaling pathway in ulcerative colitis mouse. Phytomedicine 128:155415. https:\/\/doi.org\/10.1016\/j.phymed.2024.155415","journal-title":"Phytomedicine"},{"issue":"1","key":"5218_CR57","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01917-2","volume":"8","author":"XM Yao","year":"2017","unstructured":"Yao XM, Zhang CH, Xing Y, Xue G, Zhang QP, Pan FW, Wu GJ, Hu YX, Guo QH, Lu AL, Zhang XM, Zhou RB, Tian ZG, Zeng BH, Wei H, Strober W, Zhao LP, Meng GX (2017) Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis. Nat Commun 8(1):1896. https:\/\/doi.org\/10.1038\/s41467-017-01917-2","journal-title":"Nat Commun"},{"key":"5218_CR58","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1080\/08923973.2020.1808987","volume":"42","author":"H Yousefi-Manesh","year":"2022","unstructured":"Yousefi-Manesh H, Dejban P, Mumtaz F, Abdollahi A, Chamanara M, Dehpour A, Hasanvand A, Rashidian A (2022) Risperidone attenuates acetic acid-induced colitis in rats through inhibition of TLR4\/NF-\u03baB signaling pathway. Immunopharmacol Immunotoxicol 42:464\u2013472. https:\/\/doi.org\/10.1080\/08923973.2020.1808987","journal-title":"Immunopharmacol Immunotoxicol"},{"issue":"6","key":"5218_CR59","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1002\/cbf.3826","volume":"41","author":"X Zhang","year":"2023","unstructured":"Zhang X, Wang T, Miao Y, Lin W, Zhu LT, Meng XK, Zhang FX (2023) Dauricine exhibits anti-inflammatory property against acute ulcerative colitis via the regulation of NF-\u03baB pathway. Cell Biochem Funct 41(6):713\u2013721. https:\/\/doi.org\/10.1002\/cbf.3826","journal-title":"Cell Biochem Funct"},{"issue":"23","key":"5218_CR60","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201900638","volume":"63","author":"HA Zhao","year":"2019","unstructured":"Zhao HA, Cheng N, Zhou WQ, Chen SN, Wang Q, Gao H, Xue XF, Wu LM, Cao W (2019) Honey polyphenols ameliorate DSS-induced ulcerative colitis via modulating gut microbiota in rats. Mol Nutr Food Res 63(23):e1900638. https:\/\/doi.org\/10.1002\/mnfr.201900638","journal-title":"Mol Nutr Food Res"},{"key":"5218_CR61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116293","volume":"308","author":"J Zhao","year":"2023","unstructured":"Zhao J, Wu R, Wei P, Ma Z, Pei H, Hu J, Wen F, Wan L (2023) Ethanol extract of Piper wallichii ameliorates DSS-induced ulcerative colitis in mice: involvement of TLR4\/NF-\u03baB\/COX-2 signaling pathway. J Ethnopharmacol 308:116293. https:\/\/doi.org\/10.1016\/j.jep.2023.116293","journal-title":"J Ethnopharmacol"},{"key":"5218_CR62","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2025.177390","volume":"995","author":"YL Zhao","year":"2025","unstructured":"Zhao YL, Tian XP, Yan Y, Tian SY, Liu DD, Xu JM (2025) Lithospermic acid alleviates oxidative stress and inflammation in DSS-induced colitis through Nrf2. Eur J Pharmacol 995:177390. https:\/\/doi.org\/10.1016\/j.ejphar.2025.177390","journal-title":"Eur J Pharmacol"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05218-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05218-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05218-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:18:24Z","timestamp":1781511504000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05218-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,19]]},"references-count":62,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["5218"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05218-8","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,19]]},"assertion":[{"value":"15 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The entire animal experiments were approved and supervised by the Laboratory Animal Committee of Northwest University (Approval No. 20230302).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}