{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T02:08:38Z","timestamp":1783908518073,"version":"3.55.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"crossref","award":["BT\/PR24783\/NER\/95\/851\/2017"],"award-info":[{"award-number":["BT\/PR24783\/NER\/95\/851\/2017"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s00210-026-05238-4","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T02:57:42Z","timestamp":1774580262000},"page":"13527-13538","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Repurposing gabapentin and pregabalin to improve the anticancer efficacy of 5-fluorouracil through development of a dual-drug-loaded nanoformulation"],"prefix":"10.1007","volume":"399","author":[{"given":"Chandan","family":"Raybarman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surajit","family":"Bhattacharjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratap Chandra","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"5238_CR1","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/nrd1468","volume":"3","author":"TT Ashburn","year":"2004","unstructured":"Ashburn TT, Thor KB (2004) Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov 3:673\u2013683. https:\/\/doi.org\/10.1038\/nrd1468","journal-title":"Nat Rev Drug Discov"},{"key":"5238_CR2","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/nrc2442","volume":"8","author":"G Bergers","year":"2008","unstructured":"Bergers G, Hanahan D (2008) Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8:592\u2013603. https:\/\/doi.org\/10.1038\/nrc2442","journal-title":"Nat Rev Cancer"},{"key":"5238_CR3","doi-asserted-by":"publisher","first-page":"6901","DOI":"10.1007\/s10570-018-2062-2","volume":"25","author":"M Bo\u017ei\u010d","year":"2018","unstructured":"Bo\u017ei\u010d M, Elschner T, Tkau\u010di\u010d D, Bra\u010di\u010d M, Hribernik S, Kleinschek KS, Karg R (2018) Effect of different surface active polysaccharide derivatives on the formation of ethyl cellulose particles by the emulsion-solvent evaporation method. Cellulose 25:6901\u20136922. https:\/\/doi.org\/10.1007\/s10570-018-2062-2","journal-title":"Cellulose"},{"key":"5238_CR4","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74:229\u2013263. https:\/\/doi.org\/10.3322\/caac.21834","journal-title":"CA Cancer J Clin"},{"key":"5238_CR5","doi-asserted-by":"publisher","first-page":"25458","DOI":"10.1074\/jbc.273.39.25458","volume":"273","author":"JP Brown","year":"1998","unstructured":"Brown JP, Gee NS (1998) Cloning and deletion mutagenesis of the \u03b12\u03b4 calcium channel subunit from porcine cerebral cortex. J Biol Chem 273:25458\u201325465. https:\/\/doi.org\/10.1074\/jbc.273.39.25458","journal-title":"J Biol Chem"},{"key":"5238_CR6","doi-asserted-by":"publisher","first-page":"4167","DOI":"10.1039\/c7nr07450f","volume":"10","author":"G Caracciolo","year":"2018","unstructured":"Caracciolo G (2018) Clinically approved liposomal nanomedicines: lessons learned from the biomolecular corona. Nanoscale 10:4167\u20134172. https:\/\/doi.org\/10.1039\/c7nr07450f","journal-title":"Nanoscale"},{"key":"5238_CR7","doi-asserted-by":"publisher","first-page":"17181","DOI":"10.1039\/d0cp01991g","volume":"22","author":"S Choi","year":"2020","unstructured":"Choi S, Parameswaran S, Choi J (2020) Understanding alcohol aggregates and the water hydrogen bond network towards miscibility in alcohol solutions: graph theoretical analysis. Phys Chem Chem Phys 22:17181\u201317195. https:\/\/doi.org\/10.1039\/d0cp01991g","journal-title":"Phys Chem Chem Phys"},{"key":"5238_CR8","doi-asserted-by":"publisher","first-page":"3496","DOI":"10.1002\/cmdc.202100473","volume":"16","author":"V Ciaffaglione","year":"2021","unstructured":"Ciaffaglione V, Modica MN, Pittal\u00e0 V, Romeo G, Salerno L, Intagliata S (2021) Mutual prodrugs of 5\u2010fluorouracil: from a classic chemotherapeutic agent to novel potential anticancer drugs. ChemMedChem 16:3496\u20133512. https:\/\/doi.org\/10.1002\/cmdc.202100473","journal-title":"ChemMedChem"},{"key":"5238_CR9","doi-asserted-by":"publisher","first-page":"5445","DOI":"10.2147\/IJN.S257700","volume":"15","author":"E Entezar-Almahdi","year":"2020","unstructured":"Entezar-Almahdi E, Mohammadi-Samani S, Tayebi L, Farjadian F (2020) Recent advances in designing 5-fluorouracil delivery systems: a stepping stone in the safe treatment of colorectal cancer. Int J Nanomedicine 15:5445\u20135458. https:\/\/doi.org\/10.2147\/IJN.S257700","journal-title":"Int J Nanomedicine"},{"key":"5238_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0134-x","volume":"5","author":"J Fares","year":"2020","unstructured":"Fares J, Fares MY, Khachfe HH, Salhab HA, Fares Y (2020) Molecular principles of metastasis: a hallmark of cancer revisited. Signal Transduct Target Ther 5:28. https:\/\/doi.org\/10.1038\/s41392-020-0134-x","journal-title":"Signal Transduct Target Ther"},{"key":"5238_CR11","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.ijpharm.2014.07.025","volume":"473","author":"YM Gabal","year":"2014","unstructured":"Gabal YM, Kamel AO, Sammour OA, Elshafeey AH (2014) Effect of surface charge on the brain delivery of nanostructured lipid carriers in situ gels via the nasal route. Int J Pharm 473:442\u2013457. https:\/\/doi.org\/10.1016\/j.ijpharm.2014.07.025","journal-title":"Int J Pharm"},{"key":"5238_CR12","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/s0092-8674(00)81683-9","volume":"100","author":"D Hanahan","year":"2000","unstructured":"Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57\u201370. https:\/\/doi.org\/10.1016\/s0092-8674(00)81683-9","journal-title":"Cell"},{"key":"5238_CR13","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1038\/nrc3599","volume":"13","author":"C Holohan","year":"2013","unstructured":"Holohan C, Schaeybroeck SV, Longley DB, Johnston PG (2013) Cancer drug resistance: an evolving paradigm. Nat Rev Cancer 13:714\u2013726. https:\/\/doi.org\/10.1038\/nrc3599","journal-title":"Nat Rev Cancer"},{"key":"5238_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31070-9","volume":"8","author":"W Huang","year":"2018","unstructured":"Huang W, Tsui CP, Tang CY, Gu L (2018) Effects of compositional tailoring on drug delivery behaviours of silica xerogel\/polymer core-shell composite nanoparticles. Sci Rep 8:13002. https:\/\/doi.org\/10.1038\/s41598-018-31070-9","journal-title":"Sci Rep"},{"key":"5238_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bpj.2025.07.025","volume":"124","author":"B Hughes","year":"2025","unstructured":"Hughes B, Chatterjee S, Ghafari M, Cisneros GA (2025) Effects of a cancer-associated mutation and multiple serine phosphorylation on poly(ADP-ribose) polymerase 2. Biophys J 124:1\u201310. https:\/\/doi.org\/10.1016\/j.bpj.2025.07.025","journal-title":"Biophys J"},{"key":"5238_CR16","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3109\/02652049009021842","volume":"7","author":"R Jalil","year":"1990","unstructured":"Jalil R, Nixon JR (1990) Biodegradable poly(lactic acid) and poly(lactide-co-glycolide) microcapsules: problems associated with preparative techniques and release properties. J Microencapsul 7:297\u2013325. https:\/\/doi.org\/10.3109\/02652049009021842","journal-title":"J Microencapsul"},{"key":"5238_CR17","doi-asserted-by":"publisher","first-page":"295","DOI":"10.3233\/CBM-203165","volume":"31","author":"M Li","year":"2021","unstructured":"Li M, Zhang W, Yang X, An G, Zhao W (2021) The \u03b12\u03b41 subunit of the voltage-gated calcium channel acts as a potential candidate for breast cancer tumor initial cells biomarker. Cancer Biomark 31:295\u2013305. https:\/\/doi.org\/10.3233\/CBM-203165","journal-title":"Cancer Biomark"},{"key":"5238_CR18","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1002\/cplu.202000496","volume":"85","author":"Y Liu","year":"2020","unstructured":"Liu Y, Yang G, Jin S, Xu L, Zhao C (2020) Development of high\u2010drug\u2010loading nanoparticles. ChemPlusChem 85:2143\u20132157. https:\/\/doi.org\/10.1002\/cplu.202000496","journal-title":"ChemPlusChem"},{"key":"5238_CR19","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.addr.2015.01.002","volume":"91","author":"H Maeda","year":"2015","unstructured":"Maeda H (2015) Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity. Adv Drug Deliv Rev 91:3\u20136. https:\/\/doi.org\/10.1016\/j.addr.2015.01.002","journal-title":"Adv Drug Deliv Rev"},{"key":"5238_CR20","doi-asserted-by":"publisher","unstructured":"Miladi K, Sfar S, Fessi H, Elaissari A (2016) In: Vauthier C, Ponchel G (eds) Polymer nanoparticles for nanomedicines, vol 2. Springer Nature, Switzerland, pp 17\u201334.\u00a0https:\/\/doi.org\/10.1007\/978-3-319-41421-8_2","DOI":"10.1007\/978-3-319-41421-8_2"},{"key":"5238_CR21","doi-asserted-by":"publisher","first-page":"3518","DOI":"10.1002\/jps.21270","volume":"97","author":"A Prokop","year":"2008","unstructured":"Prokop A, Davidson JM (2008) Nanovehicular intracellular delivery systems. J Pharm Sci 97:3518\u20133590. https:\/\/doi.org\/10.1002\/jps.21270","journal-title":"J Pharm Sci"},{"key":"5238_CR22","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.ijpharm.2017.08.064","volume":"532","author":"CJM Rivas","year":"2017","unstructured":"Rivas CJM, Tarhini M, Badri W, Miladi K, Greige-Gerges H, Nazari QA, Rodr\u00edguez SAG, Rom\u00e1n R\u00c1, Fessi H, Elaissari A (2017) Nanoprecipitation process: From encapsulation to drug delivery. Int J Pharm 532:66\u201381. https:\/\/doi.org\/10.1016\/j.ijpharm.2017.08.064","journal-title":"Int J Pharm"},{"key":"5238_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2020.102162","volume":"279","author":"S Shrestha","year":"2020","unstructured":"Shrestha S, Wang B, Dutta P (2020) Nanoparticle processing: understanding and controlling aggregation. Adv Colloid Interface Sci 279:102162. https:\/\/doi.org\/10.1016\/j.cis.2020.102162","journal-title":"Adv Colloid Interface Sci"},{"key":"5238_CR24","doi-asserted-by":"publisher","first-page":"630","DOI":"10.4103\/0250-474X.59544","volume":"71","author":"VR Sinha","year":"2009","unstructured":"Sinha VR, Kumar RV, Bhinge JR (2009) A stability-indicating RP-HPLC assay method for 5-fluorouracil. Indian J Pharm Sci 71:630\u2013637. https:\/\/doi.org\/10.4103\/0250-474X.59544","journal-title":"Indian J Pharm Sci"},{"key":"5238_CR25","doi-asserted-by":"publisher","first-page":"3895","DOI":"10.1039\/d0nr07339c","volume":"13","author":"T Song","year":"2021","unstructured":"Song T, Gao F, Guo S, Zhang Y, Li S, You H, Du Y (2021) A review of the role and mechanism of surfactants in the morphology control of metal nanoparticles. Nanoscale 13:3895\u20133910. https:\/\/doi.org\/10.1039\/d0nr07339c","journal-title":"Nanoscale"},{"key":"5238_CR26","doi-asserted-by":"publisher","first-page":"3049","DOI":"10.1016\/j.apsb.2022.02.002","volume":"12","author":"D Sun","year":"2022","unstructured":"Sun D, Gao W, Hu H, Zhou S (2022) Why 90% of clinical drug development fails and how to improve it? Acta Pharm Sin B 12:3049\u20133062. https:\/\/doi.org\/10.1016\/j.apsb.2022.02.002","journal-title":"Acta Pharm Sin B"},{"key":"5238_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00968","volume":"11","author":"S Tajada","year":"2020","unstructured":"Tajada S, Villalobos C (2020) Calcium permeable channels in cancer hallmarks. Front Pharmacol 11:968. https:\/\/doi.org\/10.3389\/fphar.2020.00968","journal-title":"Front Pharmacol"},{"key":"5238_CR28","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.colsurfb.2010.10.029","volume":"83","author":"Y Wang","year":"2011","unstructured":"Wang Y, Liu Z, Zhang D, Gao X, Zhang X, Duan C, Jia L, Feng F, Huang Y, Shen Y, Zhang Q (2011) Development and in vitro evaluation of deacety mycoepoxydiene nanosuspension. Colloids Surf B Biointerfaces 83:189\u2013197. https:\/\/doi.org\/10.1016\/j.colsurfb.2010.10.029","journal-title":"Colloids Surf B Biointerfaces"},{"key":"5238_CR29","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.ajps.2017.05.009","volume":"12","author":"M Zhang","year":"2017","unstructured":"Zhang M, Yang B, Liu W, Li S (2017) Influence of hydroxypropyl methylcellulose, methylcellulose, gelatin, poloxamer 407 and poloxamer 188 on the formation and stability of soybean oil-in-water emulsions. Asian J Pharm Sci 12:521\u2013531. https:\/\/doi.org\/10.1016\/j.ajps.2017.05.009","journal-title":"Asian J Pharm Sci"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05238-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05238-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05238-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T01:44:19Z","timestamp":1783907059000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05238-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["5238"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05238-4","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,27]]},"assertion":[{"value":"24 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}