{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T23:20:59Z","timestamp":1793488859538,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Special Project for Clinical Diagnosis and Treatment Technology of Key Diseases in Suzhou","award":["LCZX202320"],"award-info":[{"award-number":["LCZX202320"]}]},{"name":"Key Project of Science and Technology Development of Suzhou Science and Technology Bureau","award":["SYWD2025004"],"award-info":[{"award-number":["SYWD2025004"]}]},{"name":"Science and Technology Development Project of Suzhou Health Commission","award":["SYWD2024036"],"award-info":[{"award-number":["SYWD2024036"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s00210-026-05327-4","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T02:55:25Z","timestamp":1777344925000},"page":"15415-15432","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Discovery of lactylation-associated candidate hub genes and potential curcumin targets in intervertebral disc degeneration"],"prefix":"10.1007","volume":"399","author":[{"given":"Weiye","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binjie","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boen","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"issue":"15","key":"5327_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2025.169013","volume":"437","author":"GJ Bekker","year":"2025","unstructured":"Bekker GJ et al (2025) Protein data bank Japan: computational resources for analysis of protein structures. J Mol Biol 437(15):169013","journal-title":"J Mol Biol"},{"key":"5327_CR2","doi-asserted-by":"crossref","unstructured":"Editorial Note: Bioactive lipids in intervertebral disc (IVD) degeneration and its therapeutic implications. Biosci Rep, 2024. 44(8)","DOI":"10.1042\/BSR-2019-2117_EDN"},{"issue":"1","key":"5327_CR3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41584-021-00713-z","volume":"18","author":"V Francisco","year":"2022","unstructured":"Francisco V et al (2022) A new immunometabolic perspective of intervertebral disc degeneration. Nat Rev Rheumatol 18(1):47\u201360","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"5327_CR4","doi-asserted-by":"publisher","first-page":"29","DOI":"10.14712\/fb2025071010029","volume":"71","author":"D Gong","year":"2025","unstructured":"Gong D et al (2025) MiR-4478 promotes ferroptosis of nucleus pulposus cells through targeting SLC7A11 to induce IVDD. Folia Biol (Praha) 71(1):29\u201343","journal-title":"Folia Biol (Praha)"},{"issue":"1","key":"5327_CR5","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s13148-024-01682-2","volume":"16","author":"Y Hu","year":"2024","unstructured":"Hu Y et al (2024) Lactylation: the novel histone modification influence on gene expression, protein function, and disease. Clin Epigenetics 16(1):72","journal-title":"Clin Epigenetics"},{"key":"5327_CR6","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.2147\/DDDT.S415127","volume":"17","author":"Z Huang","year":"2023","unstructured":"Huang Z et al (2023) Zhiqiao gancao decoction ameliorates hyperalgesia in lumbar disc herniation via the CCL2\/CCR2 signaling pathway. Drug des Devel Ther 17:2239\u20132257","journal-title":"Drug des Devel Ther"},{"issue":"15","key":"5327_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e34715","volume":"10","author":"Z Huang","year":"2024","unstructured":"Huang Z et al (2024) Zhiqiao gancao decoction regulated JAK2\/STAT3\/ macrophage M1 polarization to ameliorate intervertebral disc degeneration. Heliyon 10(15):e34715","journal-title":"Heliyon"},{"issue":"4","key":"5327_CR8","first-page":"2130","volume":"16","author":"X Jiang","year":"2024","unstructured":"Jiang X et al (2024) Lactylation: an innovative approach to disease control. Aging Dis 16(4):2130\u20132150","journal-title":"Aging Dis"},{"key":"5327_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113092","volume":"151","author":"Z Jin","year":"2022","unstructured":"Jin Z et al (2022) Curcumin exerts chondroprotective effects against osteoarthritis by promoting AMPK\/PINK1\/Parkin-mediated mitophagy. Biomed Pharmacother 151:113092","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"5327_CR10","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1111\/brv.13135","volume":"100","author":"F Jing","year":"2025","unstructured":"Jing F et al (2025) Unlocking the multifaceted molecular functions and diverse disease implications of lactylation. Biol Rev Camb Philos Soc 100(1):172\u2013189","journal-title":"Biol Rev Camb Philos Soc"},{"issue":"1","key":"5327_CR11","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S (2000) KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28(1):27\u201330","journal-title":"Nucleic Acids Res"},{"key":"5327_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101902","volume":"87","author":"L Kang","year":"2023","unstructured":"Kang L et al (2023) Epigenetic modifications of inflammation in intervertebral disc degeneration. Ageing Res Rev 87:101902","journal-title":"Ageing Res Rev"},{"issue":"1","key":"5327_CR13","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/s41392-022-01151-3","volume":"7","author":"X Li","year":"2022","unstructured":"Li X et al (2022) Lactate metabolism in human health and disease. Signal Transduct Target Ther 7(1):305","journal-title":"Signal Transduct Target Ther"},{"key":"5327_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116982","volume":"177","author":"Y Li","year":"2024","unstructured":"Li Y et al (2024) Advances in the interaction of glycolytic reprogramming with lactylation. Biomed Pharmacother 177:116982","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"5327_CR15","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1186\/s12967-025-06427-0","volume":"23","author":"F Li","year":"2025","unstructured":"Li F et al (2025) LGR6 modulates intervertebral disc degeneration through regulation of macrophage efferocytosis. J Transl Med 23(1):475","journal-title":"J Transl Med"},{"key":"5327_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1150835","volume":"14","author":"Z Liu","year":"2023","unstructured":"Liu Z et al (2023) Natural products can modulate inflammation in intervertebral disc degeneration. Front Pharmacol 14:1150835","journal-title":"Front Pharmacol"},{"issue":"1\u20132","key":"5327_CR17","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1007\/s10495-024-02047-z","volume":"30","author":"Y Lv","year":"2025","unstructured":"Lv Y et al (2025) Machine learning-based analysis of programmed cell death types and key genes in intervertebral disc degeneration. Apoptosis 30(1\u20132):250\u2013266","journal-title":"Apoptosis"},{"issue":"W1","key":"5327_CR18","doi-asserted-by":"publisher","first-page":"W203","DOI":"10.1093\/nar\/gkaf365","volume":"53","author":"K Ono","year":"2025","unstructured":"Ono K et al (2025) Cytoscape web: bringing network biology to the browser. Nucleic Acids Res 53(W1):W203-w212","journal-title":"Nucleic Acids Res"},{"key":"5327_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2024.1343140","volume":"15","author":"J Pan","year":"2024","unstructured":"Pan J et al (2024) Constructing lactylation-related genes prognostic model to effectively predict the disease-free survival and treatment responsiveness in prostate cancer based on machine learning. Front Genet 15:1343140","journal-title":"Front Genet"},{"key":"5327_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1321295","volume":"14","author":"C Qin","year":"2023","unstructured":"Qin C et al (2023) Causal relationship between the blood immune cells and intervertebral disc degeneration: univariable, bidirectional and multivariable Mendelian randomization. Front Immunol 14:1321295","journal-title":"Front Immunol"},{"key":"5327_CR21","first-page":"153","volume":"12","author":"J Shen","year":"2022","unstructured":"Shen J et al (2022) Exhausted local lactate accumulation via injectable nanozyme-functionalized hydrogel microsphere for inflammation relief and tissue regeneration. Bioact Mater 12:153\u2013168","journal-title":"Bioact Mater"},{"issue":"2","key":"5327_CR22","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.4706","volume":"34","author":"X Shen","year":"2020","unstructured":"Shen X et al (2020) Pharmacokinetic study of eight bioactive components following oral administration of Zhiqiao gancao decoction and observation of its clinical efficacy. Biomed Chromatogr 34(2):e4706","journal-title":"Biomed Chromatogr"},{"issue":"25","key":"5327_CR23","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300988","volume":"10","author":"Y Shi","year":"2023","unstructured":"Shi Y et al (2023) Rescuing nucleus pulposus cells from senescence via dual-functional greigite nanozyme to alleviate intervertebral disc degeneration. Adv Sci Weinh 10(25):e2300988","journal-title":"Adv Sci Weinh"},{"issue":"23","key":"5327_CR24","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.70262","volume":"28","author":"Y Shi","year":"2024","unstructured":"Shi Y et al (2024) Integrating bulk RNA and single-cell RNA sequencing identifies and validates lactylation-related signatures for intervertebral disc degeneration. J Cell Mol Med 28(23):e70262","journal-title":"J Cell Mol Med"},{"key":"5327_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2025.110185","volume":"191","author":"A \u0160korjanc","year":"2025","unstructured":"\u0160korjanc A, Smrkolj V, Umek N (2025) GOReverseLookup: a gene ontology reverse lookup tool. Comput Biol Med 191:110185","journal-title":"Comput Biol Med"},{"issue":"1","key":"5327_CR26","doi-asserted-by":"publisher","DOI":"10.1002\/jsp2.1311","volume":"7","author":"C Song","year":"2024","unstructured":"Song C et al (2024) Bioinformatics-based discovery of intervertebral disc degeneration biomarkers and immune-inflammatory infiltrates. JOR Spine 7(1):e1311","journal-title":"JOR Spine"},{"key":"5327_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114711","volume":"162","author":"C Song","year":"2023","unstructured":"Song C et al (2023) Cellular senescence - molecular mechanisms of intervertebral disc degeneration from an immune perspective. Biomed Pharmacother 162:114711","journal-title":"Biomed Pharmacother"},{"key":"5327_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2020.105752","volume":"123","author":"VK Soni","year":"2020","unstructured":"Soni VK et al (2020) Curcumin circumvent lactate-induced chemoresistance in hepatic cancer cells through modulation of hydroxycarboxylic acid receptor-1. Int J Biochem Cell Biol 123:105752","journal-title":"Int J Biochem Cell Biol"},{"issue":"21","key":"5327_CR29","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202416149","volume":"12","author":"K Sun","year":"2025","unstructured":"Sun K et al (2025) Glycolysis-derived lactate induces ACSL4 expression and lactylation to activate ferroptosis during intervertebral disc degeneration. Adv Sci (Weinh) 12(21):e2416149","journal-title":"Adv Sci (Weinh)"},{"issue":"3","key":"5327_CR30","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s13402-023-00775-z","volume":"46","author":"JH Wang","year":"2023","unstructured":"Wang JH et al (2023) Beyond metabolic waste: lysine lactylation and its potential roles in cancer progression and cell fate determination. Cell Oncol (Dordr) 46(3):465\u2013480","journal-title":"Cell Oncol (Dordr)"},{"issue":"1","key":"5327_CR31","first-page":"54","volume":"10","author":"ZQ Wen","year":"2023","unstructured":"Wen ZQ et al (2023) Insights into the underlying pathogenesis and therapeutic potential of endoplasmic reticulum stress in degenerative musculoskeletal diseases. Mil Med Res 10(1):54","journal-title":"Mil Med Res"},{"issue":"10","key":"5327_CR32","doi-asserted-by":"publisher","first-page":"3241","DOI":"10.1016\/j.ymthe.2022.05.021","volume":"30","author":"J Wu","year":"2022","unstructured":"Wu J et al (2022) Self-amplifying loop of NF-\u03baB and periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc degeneration. Mol Ther 30(10):3241\u20133256","journal-title":"Mol Ther"},{"issue":"7","key":"5327_CR33","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1111\/os.13254","volume":"14","author":"J Xin","year":"2022","unstructured":"Xin J et al (2022) Treatment of intervertebral disc degeneration. Orthop Surg 14(7):1271\u20131280","journal-title":"Orthop Surg"},{"key":"5327_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1275606","volume":"14","author":"D Xu","year":"2023","unstructured":"Xu D et al (2023) Identification and verification of ferroptosis-related genes in the pathology of epilepsy: insights from CIBERSORT algorithm analysis. Front Neurol 14:1275606","journal-title":"Front Neurol"},{"key":"5327_CR35","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1149989","volume":"14","author":"H Yang","year":"2023","unstructured":"Yang H et al (2023) Identification of lactylation related model to predict prognostic, tumor infiltrating immunocytes and response of immunotherapy in gastric cancer. Front Immunol 14:1149989","journal-title":"Front Immunol"},{"issue":"7779","key":"5327_CR36","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","volume":"574","author":"D Zhang","year":"2019","unstructured":"Zhang D et al (2019) Metabolic regulation of gene expression by histone lactylation. Nature 574(7779):575\u2013580","journal-title":"Nature"},{"issue":"1","key":"5327_CR37","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1186\/s13018-023-03869-4","volume":"18","author":"D Zhou","year":"2023","unstructured":"Zhou D et al (2023) A review of Duhuo Jisheng decoction mechanisms in intervertebral disc degeneration in vitro and animal studies. J Orthop Surg Res 18(1):436","journal-title":"J Orthop Surg Res"},{"issue":"9","key":"5327_CR38","doi-asserted-by":"publisher","DOI":"10.1111\/eci.14226","volume":"54","author":"D Zhou","year":"2024","unstructured":"Zhou D et al (2024a) Exploration of the mode of death and potential death mechanisms of nucleus pulposus cells. Eur J Clin Invest 54(9):e14226","journal-title":"Eur J Clin Invest"},{"issue":"4","key":"5327_CR39","doi-asserted-by":"publisher","DOI":"10.1002\/jsp2.70004","volume":"7","author":"D Zhou","year":"2024","unstructured":"Zhou D et al (2024b) Identifying critical modules and biomarkers of intervertebral disc degeneration by using weighted gene co-expression network. JOR Spine 7(4):e70004","journal-title":"JOR Spine"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05327-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05327-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05327-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:06:42Z","timestamp":1784776002000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05327-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["5327"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05327-4","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"assertion":[{"value":"16 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}