{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:00:42Z","timestamp":1784782842951,"version":"3.55.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s00210-026-05332-7","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T04:21:18Z","timestamp":1776486078000},"page":"14945-14964","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aucubin inhibits epithelial-mesenchymal transition and angiogenesis in colorectal cancer via the HDAC6\/PI3K\/Akt signaling pathway"],"prefix":"10.1007","volume":"399","author":[{"given":"Jinsong","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengnan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiyun","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"issue":"9","key":"5332_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2013.35","volume":"2","author":"D Ahmed","year":"2013","unstructured":"Ahmed D, Eide P, Eilertsen I, Danielsen S, Ekn\u00e6s M, Hektoen M, Lind G, Lothe R (2013) Epigenetic and genetic features of 24 colon cancer cell lines. Oncogenesis 2(9):e71\u2013e71","journal-title":"Oncogenesis"},{"issue":"13","key":"5332_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17132163","volume":"17","author":"A Al-Kabani","year":"2025","unstructured":"Al-Kabani A, Huda B, Haddad J, Yousuf M, Bhurka F, Ajaz F, Patnaik R, Jannati S, Banerjee Y (2025) Exploring experimental models of colorectal cancer: a critical appraisal from 2D cell systems to organoids, humanized mouse avatars, organ-on-chip, CRISPR engineering, and AI-driven platforms\u2014challenges and opportunities for translational precision oncology. Cancers 17(13):2163","journal-title":"Cancers"},{"issue":"7","key":"5332_CR3","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1001\/jama.2021.0106","volume":"325","author":"LH Biller","year":"2021","unstructured":"Biller LH, Schrag D (2021) Diagnosis and treatment of metastatic colorectal cancer: a review. JAMA 325(7):669\u2013685","journal-title":"JAMA"},{"issue":"9","key":"5332_CR4","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.2174\/0929867328666210902145102","volume":"29","author":"D Bonanni","year":"2022","unstructured":"Bonanni D, Citarella A, Moi D, Pinzi L, Bergamini E, Rastelli G (2022) Dual targeting strategies on histone deacetylase 6 (HDAC6) and heat shock protein 90 (Hsp90). Curr Med Chem 29(9):1474\u20131502","journal-title":"Curr Med Chem"},{"issue":"16","key":"5332_CR5","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-4043","volume":"9","author":"S Chen","year":"2021","unstructured":"Chen S, Shen Z, Gao L, Yu S, Zhang P, Han Z, Kang M (2021) TPM3 mediates epithelial-mesenchymal transition in esophageal cancer via MMP2\/MMP9. Ann Transl Med 9(16):1338","journal-title":"Ann Transl Med"},{"key":"5332_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116472","volume":"312","author":"J Choudhari","year":"2023","unstructured":"Choudhari J, Nimma R, Nimal SK, Venkata SKT, Kundu GC, Gacche RN (2023) Prosopis juliflora (Sw.) DC phytochemicals induce apoptosis and inhibit cell proliferation signaling pathways, EMT, migration, invasion, angiogenesis and stem cell markers in melanoma cell lines. J Ethnopharmacol 312:116472","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"5332_CR7","doi-asserted-by":"publisher","first-page":"3375","DOI":"10.3390\/ijms23063375","volume":"23","author":"D Dakowicz","year":"2022","unstructured":"Dakowicz D, Zajkowska M, Mroczko B (2022) Relationship between VEGF family members, their receptors and cell death in the neoplastic transformation of colorectal cancer. Int J Mol Sci 23(6):3375","journal-title":"Int J Mol Sci"},{"key":"5332_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.215911","volume":"549","author":"Y Deng","year":"2022","unstructured":"Deng Y, Gao J, Xu G, Yao Y, Sun Y, Shi Y, Hao X, Niu L, Li H (2022) Hdac6-dependent deacetylation of AKAP12 dictates its ubiquitination and promotes colon cancer metastasis. Cancer Lett 549:215911. https:\/\/doi.org\/10.1016\/j.canlet.2022.215911","journal-title":"Cancer Lett"},{"key":"5332_CR9","doi-asserted-by":"publisher","DOI":"10.2147\/JHC.S452924","author":"Y-Q Du","year":"2024","unstructured":"Du Y-Q, Yuan B, Ye Y-X, Zhou F-l, Liu H, Huang J-J, Wei Y-F (2024) Plumbagin regulates snail to inhibit hepatocellular carcinoma epithelial-mesenchymal transition in vivo and in vitro. J Hepatocell Carcinoma. https:\/\/doi.org\/10.2147\/JHC.S452924","journal-title":"J Hepatocell Carcinoma"},{"key":"5332_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175586","volume":"949","author":"S Ghalehbandi","year":"2023","unstructured":"Ghalehbandi S, Yuzugulen J, Pranjol MZI, Pourgholami MH (2023) The role of VEGF in cancer-induced angiogenesis and research progress of drugs targeting VEGF. Eur J Pharmacol 949:175586","journal-title":"Eur J Pharmacol"},{"issue":"21","key":"5332_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111469","volume":"22","author":"L Greco","year":"2021","unstructured":"Greco L, Rubbino F, Morelli A, Gaiani F, Grizzi F, de\u2019Angelis GL, Malesci A, Laghi L (2021) Epithelial to mesenchymal transition: a challenging playground for translational research. Current models and focus on TWIST1 relevance and gastrointestinal cancers. Int J Mol Sci 22(21):11469","journal-title":"Int J Mol Sci"},{"issue":"1","key":"5332_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00828-5","volume":"6","author":"Y He","year":"2021","unstructured":"He Y, Sun MM, Zhang GG, Yang J, Chen KS, Xu WW, Li B (2021) Targeting PI3K\/Akt signal transduction for cancer therapy. Signal Transduct Target Ther 6(1):425","journal-title":"Signal Transduct Target Ther"},{"issue":"5","key":"5332_CR13","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/s41416-019-0695-z","volume":"122","author":"P Hou","year":"2020","unstructured":"Hou P, Shi P, Jiang T, Yin H, Chu S, Shi M, Bai J, Song J (2020) DKC1 enhances angiogenesis by promoting HIF-1\u03b1 transcription and facilitates metastasis in colorectal cancer. Br J Cancer 122(5):668\u2013679. https:\/\/doi.org\/10.1038\/s41416-019-0695-z","journal-title":"Br J Cancer"},{"issue":"2","key":"5332_CR14","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.144","volume":"3","author":"Z Huang","year":"2022","unstructured":"Huang Z, Zhang Z, Zhou C, Liu L, Huang C (2022a) Epithelial\u2013mesenchymal transition: the history, regulatory mechanism, and cancer therapeutic opportunities. MedComm 3(2):e144","journal-title":"MedComm"},{"issue":"1","key":"5332_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01347-8","volume":"15","author":"Y Huang","year":"2022","unstructured":"Huang Y, Hong W, Wei X (2022b) The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis. J Hematol Oncol 15(1):129","journal-title":"J Hematol Oncol"},{"issue":"8","key":"5332_CR16","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1177\/1078155220904151","volume":"26","author":"M Inanc","year":"2020","unstructured":"Inanc M, Sirakaya HA, Karaman H, Bozkurt O (2020) The prognostic importance of VEGF-A, PDGF-BB and c-MET in patients with metastatic colorectal cancer. J Oncol Pharm Pract 26(8):1878\u20131885","journal-title":"J Oncol Pharm Pract"},{"key":"5332_CR17","doi-asserted-by":"crossref","unstructured":"Jiang W, Liu S, Fu L (2025a) HDAC6 as a therapeutic target for HPV E7-driven cervical cancer. Genome Instability Dis 1\u201312","DOI":"10.1007\/s42764-025-00154-y"},{"issue":"1","key":"5332_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-025-00949-y","volume":"9","author":"Y Jiang","year":"2025","unstructured":"Jiang Y, Zhang J, Yu J, Luo W, Du Q, Liu W, Xu Q, Li X, Liu H, Huang D (2025b) HDAC6 facilitates LUAD progression by inducing EMT and enhancing macrophage polarization towards the M2 phenotype. NPJ Precis Oncol 9(1):150","journal-title":"NPJ Precis Oncol"},{"issue":"10","key":"5332_CR19","doi-asserted-by":"publisher","first-page":"4154","DOI":"10.3390\/molecules28104154","volume":"28","author":"K Kartini","year":"2023","unstructured":"Kartini K, Irawan MA, Setiawan F, Jayani NIE (2023) Characteristics, isolation methods, and biological properties of aucubin. Molecules 28(10):4154","journal-title":"Molecules"},{"issue":"5","key":"5332_CR20","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1007\/s13402-022-00704-6","volume":"45","author":"S Kaur","year":"2022","unstructured":"Kaur S, Rajoria P, Chopra M (2022) HDAC6: a unique HDAC family member as a cancer target. Cell Oncol 45(5):779\u2013829","journal-title":"Cell Oncol"},{"key":"5332_CR21","doi-asserted-by":"publisher","DOI":"10.3390\/cells11040702","author":"GI Khandakar","year":"2022","unstructured":"Khandakar GI, Satoh R, Takasaki T, Fujitani K, Tanabe G, Sakai K, Nishio K, Sugiura R (2022) ACAGT-007a, an ERK MAPK signaling modulator, in combination with AKT signaling inhibition induces apoptosis in KRAS mutant pancreatic cancer T3M4 and MIA-Pa-Ca-2 cells. Cells. https:\/\/doi.org\/10.3390\/cells11040702","journal-title":"Cells"},{"issue":"9","key":"5332_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/nu13092974","volume":"13","author":"C-W Kim","year":"2021","unstructured":"Kim C-W, Choi K-C (2021) Potential roles of iridoid glycosides and their underlying mechanisms against diverse cancer growth and metastasis: do they have an inhibitory effect on cancer progression? Nutrients 13(9):2974","journal-title":"Nutrients"},{"issue":"1","key":"5332_CR23","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04120-8","volume":"21","author":"Z Li","year":"2023","unstructured":"Li Z, Yang Z, Liu W, Zhu W, Yin L, Han Z, Xian Y, Wen J, Tang H, Lin X (2023) Disheveled3 enhanced EMT and cancer stem-like cells properties via Wnt\/\u03b2-catenin\/c-Myc\/SOX2 pathway in colorectal cancer. J Transl Med 21(1):302","journal-title":"J Transl Med"},{"issue":"1","key":"5332_CR24","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s10495-024-02015-7","volume":"30","author":"X Li","year":"2025","unstructured":"Li X, Jiang Z, Li J, Yang K, He J, Deng Q, Xu S, Jiang Z, Liu F, Jiang Z (2025) PRELP inhibits colorectal cancer progression by suppressing epithelial-mesenchymal transition and angiogenesis via the inactivation of the FGF1\/PI3K\/AKT pathway. Apoptosis 30(1):16\u201334","journal-title":"Apoptosis"},{"issue":"1","key":"5332_CR25","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-022-00641-4","volume":"17","author":"F Liu","year":"2022","unstructured":"Liu F, Liang Y, Sun R, Yang W, Liang Z, Gu J, Zhao F, Tang D (2022) Astragalus mongholicus Bunge and Curcuma aromatica Salisb. inhibits liver metastasis of colon cancer by regulating EMT via the CXCL8\/CXCR2 axis and PI3K\/AKT\/mTOR signaling pathway. Chin Med 17(1):91","journal-title":"Chin Med"},{"issue":"1","key":"5332_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41538-024-00341-3","volume":"8","author":"S Liu","year":"2024","unstructured":"Liu S, Ai Z, Hu Y, Ren G, Zhang J, Tang P, Zou H, Li X, Wang Y, Nan B (2024) Ginseng glucosyl oleanolate inhibit cervical cancer cell proliferation and angiogenesis via PI3K\/AKT\/HIF-1\u03b1 pathway. NPJ Sci Food 8(1):105","journal-title":"NPJ Sci Food"},{"issue":"1","key":"5332_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01225-x","volume":"21","author":"A Maharati","year":"2023","unstructured":"Maharati A, Moghbeli M (2023) PI3K\/AKT signaling pathway as a critical regulator of epithelial-mesenchymal transition in colorectal tumor cells. Cell Commun Signal 21(1):201","journal-title":"Cell Commun Signal"},{"key":"5332_CR28","doi-asserted-by":"publisher","DOI":"10.1177\/15330338221081219","volume":"21","author":"Q Ni","year":"2022","unstructured":"Ni Q, Li M, Yu S (2022) Research progress of epithelial-mesenchymal transition treatment and drug resistance in colorectal cancer. Technol Cancer Res Treat 21:15330338221081219","journal-title":"Technol Cancer Res Treat"},{"issue":"6","key":"5332_CR29","first-page":"4177","volume":"19","author":"Y Ohnishi","year":"2020","unstructured":"Ohnishi Y, Sakamoto T, Zhengguang L, Yasui H, Hamada H, Kubo H, Nakajima M (2020) Curcumin inhibits epithelial-mesenchymal transition in oral cancer cells via c-Met blockade. Oncol Lett 19(6):4177\u20134182","journal-title":"Oncol Lett"},{"key":"5332_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031672","author":"JT Pai","year":"2022","unstructured":"Pai JT, Chen XH, Leu YL, Weng MS (2022) Propolin G-suppressed epithelial-to-mesenchymal transition in triple-negative breast cancer cells via glycogen synthase kinase 3\u03b2-mediated snail and HDAC6-regulated vimentin degradation. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms23031672","journal-title":"Int J Mol Sci"},{"issue":"6","key":"5332_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25063461","volume":"25","author":"JH Park","year":"2024","unstructured":"Park JH, Lee T-K, Kim DW, Ahn JH, Shin MC, Cho JH, Won M-H, Kang IJ (2024) Neuroprotective effects of aucubin against cerebral ischemia and ischemia injury through the inhibition of the TLR4\/NF-\u03baB inflammatory signaling pathway in gerbils. Int J Mol Sci 25(6):3461","journal-title":"Int J Mol Sci"},{"key":"5332_CR32","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/goac035","volume":"10","author":"S Parmar","year":"2022","unstructured":"Parmar S, Easwaran H (2022) Genetic and epigenetic dependencies in colorectal cancer development. Gastroenterol Rep 10:goac035","journal-title":"Gastroenterol Rep"},{"key":"5332_CR33","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.biochi.2022.02.003","volume":"197","author":"D Paulin","year":"2022","unstructured":"Paulin D, Lilienbaum A, Kardjian S, Agbulut O, Li Z (2022) Vimentin: regulation and pathogenesis. Biochimie 197:96\u2013112","journal-title":"Biochimie"},{"issue":"2","key":"5332_CR34","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s10549-025-07723-5","volume":"212","author":"E Perez-Moreno","year":"2025","unstructured":"Perez-Moreno E, Ortega-Hern\u00e1ndez V, Zavala VA, Gamboa J, Fern\u00e1ndez W, Carvallo P (2025) Suppression of breast cancer metastatic behavior by microRNAs targeting EMT transcription factors. A relevant participation of miR-196a-5p and miR-22-3p in ZEB1 expression. Breast Cancer Res Treat 212(2):277\u2013290","journal-title":"Breast Cancer Res Treat"},{"key":"5332_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105274","volume":"163","author":"S Pulya","year":"2021","unstructured":"Pulya S, Amin SA, Adhikari N, Biswas S, Jha T, Ghosh B (2021) HDAC6 as privileged target in drug discovery: a perspective. Pharmacol Res 163:105274","journal-title":"Pharmacol Res"},{"issue":"21","key":"5332_CR36","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v31.i21.106964","volume":"31","author":"G-X Qi","year":"2025","unstructured":"Qi G-X, Zhao R-X, Gao C, Ma Z-Y, Wang S, Xu J (2025) Recent advances and challenges in colorectal cancer: from molecular research to treatment. World J Gastroenterol 31(21):106964","journal-title":"World J Gastroenterol"},{"key":"5332_CR37","doi-asserted-by":"publisher","DOI":"10.31083\/FBL45321","author":"RJ Reiter","year":"2025","unstructured":"Reiter RJ (2025) Melatonin and lipid peroxidation: antioxidant shield and therapeutic potential. Front Biosci Landmark. https:\/\/doi.org\/10.31083\/FBL45321","journal-title":"Front Biosci Landmark"},{"issue":"1","key":"5332_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.64229\/fbzn4v28","volume":"1","author":"Z Rezaei","year":"2025","unstructured":"Rezaei Z, Sadri F (2025) Exosome-mediated ferroptosis regulation in gastric cancer: mechanisms, challenges, and therapeutic potential. Curr Cancer Res 1(1):1\u201315","journal-title":"Curr Cancer Res"},{"issue":"6","key":"5332_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2020.100773","volume":"13","author":"D Ribatti","year":"2020","unstructured":"Ribatti D, Tamma R, Annese T (2020) Epithelial-mesenchymal transition in cancer: a historical overview. Transl Oncol 13(6):100773","journal-title":"Transl Oncol"},{"issue":"14","key":"5332_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13143433","volume":"13","author":"D Ribatti","year":"2021","unstructured":"Ribatti D, Solimando AG, Pezzella F (2021) The anti-VEGF (R) drug discovery legacy: improving attrition rates by breaking the vicious cycle of angiogenesis in cancer. Cancers 13(14):3433","journal-title":"Cancers"},{"key":"5332_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114395","volume":"160","author":"E Sabouni","year":"2023","unstructured":"Sabouni E, Nejad MM, Mojtabavi S, Khoshdooz S, Mojtabavi M, Nadafzadeh N, Nikpanjeh N, Mirzaei S, Hashemi M, Aref AR (2023) Unraveling the function of epithelial-mesenchymal transition (EMT) in colorectal cancer: metastasis, therapy response, and revisiting molecular pathways. Biomed Pharmacother 160:114395","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"5332_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.63623\/vkebd166","volume":"2","author":"F Sadri","year":"2025","unstructured":"Sadri F (2025) Protacs in colorectal cancer: a new era in targeted protein degradation therapy. Adv Clin Pharmacol Ther 2(1):1\u20136","journal-title":"Adv Clin Pharmacol Ther"},{"issue":"9","key":"5332_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13092025","volume":"13","author":"T Sawicki","year":"2021","unstructured":"Sawicki T, Ruszkowska M, Danielewicz A, Nied\u017awiedzka E, Ar\u0142ukowicz T, Przyby\u0142owicz KE (2021) A review of colorectal cancer in terms of epidemiology, risk factors, development, symptoms and diagnosis. Cancers 13(9):2025","journal-title":"Cancers"},{"key":"5332_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscia.2024.100057","volume":"2","author":"P Shang","year":"2024","unstructured":"Shang P, Yang J, Shao L, Sun C, Ji J, Wang X, Zheng Z, Guo X (2024) Quercetin inhibits malignant progression of high metastatic advanced colon cancer in hypoxia via suppressing ROS and PI3K\/AKT pathway. Pharm Sci Adv 2:100057","journal-title":"Pharm Sci Adv"},{"issue":"2","key":"5332_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2024.189079","volume":"1879","author":"P Shaw","year":"2024","unstructured":"Shaw P, Dwivedi SKD, Bhattacharya R, Mukherjee P, Rao G (2024) VEGF signaling: role in angiogenesis and beyond. Biochimica Et Biophysica Acta (BBA)-Rev Cancer 1879(2):189079","journal-title":"Biochimica Et Biophysica Acta (BBA)-Rev Cancer"},{"issue":"11","key":"5332_CR46","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25115806","volume":"25","author":"R \u015awiechowski","year":"2024","unstructured":"\u015awiechowski R, Pietrzak J, Wosiak A, Mik M, Balcerczak E (2024) Genetic insights into colorectal cancer: evaluating PI3K\/AKT signaling pathway genes expression. Int J Mol Sci 25(11):5806","journal-title":"Int J Mol Sci"},{"key":"5332_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12935-021-01920-0","volume":"21","author":"Y Tang","year":"2021","unstructured":"Tang Y, Zong S, Zeng H, Ruan X, Yao L, Han S, Hou F (2021) Micrornas and angiogenesis: a new era for the management of colorectal cancer. Cancer Cell Int 21:1\u201311","journal-title":"Cancer Cell Int"},{"issue":"12","key":"5332_CR48","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1007\/s12094-021-02653-2","volume":"23","author":"S Tong","year":"2021","unstructured":"Tong S, Zhang X, Guo H, Yang J, Qi Y, Lu S (2021) Study on effects of mir-141-3p in proliferation, migration, invasion and apoptosis of colon cancer cells by inhibiting Bcl2. Clin Transl Oncol 23(12):2526\u20132535","journal-title":"Clin Transl Oncol"},{"issue":"7","key":"5332_CR49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0253258","volume":"16","author":"SLB Truelsen","year":"2021","unstructured":"Truelsen SLB, Mousavi N, Wei H, Harvey L, Stausholm R, Spillum E, Hagel G, Qvortrup K, Thastrup O, Harling H (2021) The cancer angiogenesis co-culture assay: in vitro quantification of the angiogenic potential of tumoroids. PLoS One 16(7):e0253258","journal-title":"PLoS One"},{"issue":"1","key":"5332_CR50","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16010054","volume":"16","author":"A Vuleti\u0107","year":"2023","unstructured":"Vuleti\u0107 A, Mirja\u010di\u0107 Martinovi\u0107 K, Spasi\u0107 J (2023) Role of histone deacetylase 6 and histone deacetylase 6 inhibition in colorectal cancer. Pharmaceutics 16(1):54","journal-title":"Pharmaceutics"},{"issue":"1","key":"5332_CR51","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-022-02477-0","volume":"41","author":"L Wang","year":"2022","unstructured":"Wang L, Li S, Luo H, Lu Q, Yu S (2022) PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K\/AKT signaling in tumor cells and phenotypic polarization of macrophages. J Exp Clin Cancer Res 41(1):303","journal-title":"J Exp Clin Cancer Res"},{"issue":"14","key":"5332_CR52","doi-asserted-by":"publisher","first-page":"15289","DOI":"10.1002\/cam4.6173","volume":"12","author":"H Wang","year":"2023","unstructured":"Wang H, Chen X, Jin Y, Liu T, Song Y, Zhu X, Zhu X (2023a) The role of DYNLT3 in breast cancer proliferation, migration, and invasion via epithelial-to-mesenchymal transition. Cancer Med 12(14):15289\u201315303","journal-title":"Cancer Med"},{"issue":"6","key":"5332_CR53","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2023.13857","volume":"25","author":"W Wang","year":"2023","unstructured":"Wang W, Jin J, Zhou Z, Wang Y, Min K, Zuo X, Jiang J, Zhou Y, Shi J (2023b) Snail inhibits metastasis via regulation of E\u2011cadherin and is associated with prognosis in colorectal cancer. Oncol Lett 25(6):271","journal-title":"Oncol Lett"},{"key":"5332_CR54","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252111686","author":"K Wang","year":"2024","unstructured":"Wang K, Tao L, Zhu M, Yu X, Lu Y, Yuan B, Hu F (2024) Melittin inhibits colorectal cancer growth and metastasis by activating the mitochondrial apoptotic pathway and suppressing epithelial-mesenchymal transition and angiogenesis. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms252111686","journal-title":"Int J Mol Sci"},{"issue":"5","key":"5332_CR55","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1016\/j.apsb.2020.11.018","volume":"11","author":"Z Xu","year":"2021","unstructured":"Xu Z, Zhou Z, Zhang J, Xuan F, Fan M, Zhou D, Liuyang Z, Ma X, Hong Y, Wang Y (2021) Targeting BMI-1-mediated epithelial\u2013mesenchymal transition to inhibit colorectal cancer liver metastasis. Acta Pharm Sin B 11(5):1274\u20131285","journal-title":"Acta Pharm Sin B"},{"key":"5332_CR56","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.semcancer.2022.03.011","volume":"86","author":"Y Yang","year":"2022","unstructured":"Yang Y, Cao Y, Elsevier (2022b) The impact of VEGF on cancer metastasis and systemic disease. In. Semin Cancer Biol 86:251\u2013261","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"5332_CR57","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1080\/13880209.2022.2074057","volume":"60","author":"P Yang","year":"2022","unstructured":"Yang P, Zhang Q, Shen H, Bai X, Liu P, Zhang T (2022a) Research progress on the protective effects of aucubin in neurological diseases. Pharm Biol 60(1):1088\u20131094","journal-title":"Pharm Biol"},{"key":"5332_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2024.116829","volume":"483","author":"F Yang","year":"2024","unstructured":"Yang F, Lian Q, Zhang X, Sun F, Jia S, Zhao W (2024) Aucubin provides protection against cerebral ischaemia-reperfusion injury by suppressing neuronal apoptosis, oxidative stress, and inflammation through the modulation of the AKT-GSK-3\u03b2-Nrf2 signal cascade. Toxicol Appl Pharmacol 483:116829","journal-title":"Toxicol Appl Pharmacol"},{"issue":"1","key":"5332_CR59","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01744-8","volume":"22","author":"Z Yuan","year":"2023","unstructured":"Yuan Z, Li Y, Zhang S, Wang X, Dou H, Yu X, Zhang Z, Yang S, Xiao M (2023) Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments. Mol Cancer 22(1):48","journal-title":"Mol Cancer"},{"issue":"28","key":"5332_CR60","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.2174\/1381612828666220728152350","volume":"28","author":"N Zafari","year":"2022","unstructured":"Zafari N, Velayati M, Nassiri M, Khazaei M, Hassanian SM, Ferns GA, Avan A (2022) Pharmacological targeting of epithelial-to-mesenchymal transition in colorectal cancer. Curr Pharm Des 28(28):2298\u20132311","journal-title":"Curr Pharm Des"},{"issue":"8","key":"5332_CR61","doi-asserted-by":"publisher","first-page":"e358","DOI":"10.1016\/S1470-2045(21)00343-0","volume":"22","author":"N Zhang","year":"2021","unstructured":"Zhang N, Ng AS, Cai S, Li Q, Yang L, Kerr D (2021) Novel therapeutic strategies: targeting epithelial\u2013mesenchymal transition in colorectal cancer. Lancet Oncol 22(8):e358\u2013e368","journal-title":"Lancet Oncol"},{"key":"5332_CR62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12906-021-03494-w","volume":"22","author":"G Zhang","year":"2022","unstructured":"Zhang G, Li Z, Dong J, Zhou W, Zhang Z, Que Z, Zhu X, Xu Y, Cao N, Zhao A (2022) Acacetin inhibits invasion, migration and TGF-\u03b21-induced EMT of gastric cancer cells through the PI3K\/Akt\/Snail pathway. BMC Complement Med Ther 22:1\u201312","journal-title":"BMC Complement Med Ther"},{"issue":"5","key":"5332_CR63","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1002\/med.21963","volume":"43","author":"W Zhao","year":"2023","unstructured":"Zhao W, Zheng XD, Tang PYZ, Li HM, Liu X, Zhong JJ, Tang YJ (2023) Advances of antitumor drug discovery in traditional Chinese medicine and natural active products by using multi\u2010active components combination. Med Res Rev 43(5):1778\u20131808","journal-title":"Med Res Rev"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05332-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05332-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05332-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:02:39Z","timestamp":1784779359000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05332-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,18]]},"references-count":63,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["5332"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05332-7","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,18]]},"assertion":[{"value":"13 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by Zhengzhou University Committee(Approval No.: 2024-KY-0263).","order":1,"name":"Ethics","label":"Ethic approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The manuscript has neither been previously published nor is under consideration by any other journal. The authors have all approved the content of the paper.","order":2,"name":"Ethics","label":"Consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}