{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:00:43Z","timestamp":1784779243133,"version":"3.55.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Bengbu Medical College Research Project Plan","award":["2023byzd005"],"award-info":[{"award-number":["2023byzd005"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s00210-026-05336-3","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:04:40Z","timestamp":1776233080000},"page":"14911-14925","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["FOXK2\/SH2D3A axis recruits EGFR to drive papillary thyroid cancer progression and confers sensitivity to EGFR inhibition"],"prefix":"10.1007","volume":"399","author":[{"given":"Qin","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xulin","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bimin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"5336_CR1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.14670\/HH-18-277","volume":"36","author":"I Abe","year":"2021","unstructured":"Abe I, Lam AK (2021) Anaplastic thyroid carcinoma: updates on WHO classification, clinicopathological features and staging. Histol Histopathol 36:239\u2013248. https:\/\/doi.org\/10.14670\/HH-18-277","journal-title":"Histol Histopathol"},{"key":"5336_CR2","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1001\/jama.2023.26348","volume":"331","author":"L Boucai","year":"2024","unstructured":"Boucai L, Zafereo M, Cabanillas ME (2024) Thyroid cancer: a review. JAMA 331:425\u2013435. https:\/\/doi.org\/10.1001\/jama.2023.26348","journal-title":"JAMA"},{"key":"5336_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-9-278","volume":"9","author":"D Caccia","year":"2010","unstructured":"Caccia D, Miccich\u00e8 F, Cassinelli G, Mondellini P, Casalini P, Bongarzone I (2010) Dasatinib reduces FAK phosphorylation increasing the effects of RPI-1 inhibition in a RET\/PTC1-expressing cell line. Mol Cancer 9:278. https:\/\/doi.org\/10.1186\/1476-4598-9-278","journal-title":"Mol Cancer"},{"key":"5336_CR4","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax5819","volume":"6","author":"Y Chen","year":"2020","unstructured":"Chen Y, Wu J, Liang G, Geng G, Zhao F, Yin P, Nowsheen S, Wu C, Li Y, Li L, Kim W, Zhou Q, Huang J, Liu J, Zhang C, Guo G, Deng M, Tu X, Gao X, Liu Z, Chen Y, Lou Z, Luo K, Yuan J (2020) CHK2-FOXK axis promotes transcriptional control of autophagy programs. Sci Adv 6:eaax5819. https:\/\/doi.org\/10.1126\/sciadv.aax5819","journal-title":"Sci Adv"},{"key":"5336_CR5","doi-asserted-by":"publisher","first-page":"6115","DOI":"10.1038\/s41388-021-01830-5","volume":"40","author":"H Feng","year":"2021","unstructured":"Feng H, Jin Z, Liang J, Zhao Q, Zhan L, Yang Z, Yan J, Kuang J, Cheng X, Qiu W (2021) FOXK2 transcriptionally activating VEGFA induces apatinib resistance in anaplastic thyroid cancer through the VEGFA\/VEGFR1 pathway. Oncogene 40:6115\u20136129. https:\/\/doi.org\/10.1038\/s41388-021-01830-5","journal-title":"Oncogene"},{"key":"5336_CR6","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1093\/jb\/mvq004","volume":"147","author":"Y Fujii","year":"2010","unstructured":"Fujii Y, Nakamura M (2010) FOXK2 transcription factor is a novel G\/T-mismatch DNA-binding protein. J Biochem 147:705\u2013709. https:\/\/doi.org\/10.1093\/jb\/mvq004","journal-title":"J Biochem"},{"key":"5336_CR7","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.3390\/ijms22041950","volume":"22","author":"J Hu","year":"2021","unstructured":"Hu J, Yuan IJ, Mirshahidi S, Simental A, Lee SC, Yuan X (2021) Thyroid carcinoma: phenotypic features, underlying biology and potential relevance for targeting therapy. Int J Mol Sci 22:1950. https:\/\/doi.org\/10.3390\/ijms22041950","journal-title":"Int J Mol Sci"},{"key":"5336_CR8","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1093\/nar\/gkaa1281","volume":"49","author":"Z Ji","year":"2021","unstructured":"Ji Z, Li Y, Liu SX, Sharrocks AD (2021) The forkhead transcription factor FOXK2 premarks lineage-specific genes in human embryonic stem cells for activation during differentiation. Nucleic Acids Res 49:1345\u20131363. https:\/\/doi.org\/10.1093\/nar\/gkaa1281","journal-title":"Nucleic Acids Res"},{"key":"5336_CR9","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1007\/s12020-022-03180-y","volume":"79","author":"S Jiang","year":"2023","unstructured":"Jiang S, Huang Y, Li Y, Gu Q, Jiang C, Tao X, Sun J (2023) Silencing FOXP2 reverses vemurafenib resistance in BRAFV600E mutant papillary thyroid cancer and melanoma cells. Endocrine 79:86\u201397. https:\/\/doi.org\/10.1007\/s12020-022-03180-y","journal-title":"Endocrine"},{"key":"5336_CR10","doi-asserted-by":"publisher","first-page":"4938","DOI":"10.2741\/3053","volume":"13","author":"T Kaneko","year":"2008","unstructured":"Kaneko T, Li L, Li SSC (2008) The SH3 domain: a family of versatile peptide- and protein-recognition modules. Front Biosci 13:4938\u20134952. https:\/\/doi.org\/10.2741\/3053","journal-title":"Front Biosci"},{"key":"5336_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.967625","volume":"12","author":"Y Kang","year":"2022","unstructured":"Kang Y, Zhang K, Sun L, Zhang Y (2022) Regulation and roles of FOXK2 in cancer. Front Oncol 12:967625. https:\/\/doi.org\/10.3389\/fonc.2022.967625","journal-title":"Front Oncol"},{"key":"5336_CR12","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.2741\/3292","volume":"14","author":"MM Kasembeli","year":"2009","unstructured":"Kasembeli MM, Xu X, Tweardy DJ (2009) SH2 domain binding to phosphopeptide ligands: potential for drug targeting. Front Biosci (Landmark Ed) 14:1010\u20131022. https:\/\/doi.org\/10.2741\/3292","journal-title":"Front Biosci (Landmark Ed)"},{"key":"5336_CR13","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1101\/gr.261016.120","volume":"30","author":"P Kolovos","year":"2020","unstructured":"Kolovos P, Nishimura K, Sankar A, Sidoli S, Cloos PA, Helin K, Christensen J (2020) PR-DUB maintains the expression of critical genes through FOXK1\/2- and ASXL1\/2\/3-dependent recruitment to chromatin and H2AK119ub1 deubiquitination. Genome Res 30:1119\u20131130. https:\/\/doi.org\/10.1101\/gr.261016.120","journal-title":"Genome Res"},{"key":"5336_CR14","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1515\/med-2020-0129","volume":"15","author":"J Kong","year":"2020","unstructured":"Kong J, Zhang Q, Liang X, Sun W (2020) FOXK2 downregulation suppresses EMT in hepatocellular carcinoma. Open Med (Wars) 15:702\u2013708. https:\/\/doi.org\/10.1515\/med-2020-0129","journal-title":"Open Med (Wars)"},{"key":"5336_CR15","doi-asserted-by":"publisher","first-page":"858","DOI":"10.7150\/jca.60730","volume":"13","author":"S Li","year":"2022","unstructured":"Li S, Wang P, Ju H, Zhu T, Shi J, Huang Y (2022) FOXK2 promotes the proliferation of papillary thyroid cancer cells by downregulating autophagy. J Cancer 13:858\u2013868. https:\/\/doi.org\/10.7150\/jca.60730","journal-title":"J Cancer"},{"key":"5336_CR16","doi-asserted-by":"publisher","first-page":"4356","DOI":"10.3892\/mmr.2018.9466","volume":"18","author":"X Liu","year":"2018","unstructured":"Liu X, Wei X, Niu W, Wang D, Wang B, Zhuang H (2018) Downregulation of FOXK2 is associated with poor prognosis in patients with gastric cancer. Mol Med Rep 18:4356\u20134364. https:\/\/doi.org\/10.3892\/mmr.2018.9466","journal-title":"Mol Med Rep"},{"key":"5336_CR17","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"5336_CR18","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1097\/PAP.0000000000000184","volume":"25","author":"MC Nath","year":"2018","unstructured":"Nath MC, Erickson LA (2018) Aggressive variants of papillary thyroid carcinoma: hobnail, tall cell, columnar, and solid. Adv Anat Pathol 25:172\u2013179. https:\/\/doi.org\/10.1097\/PAP.0000000000000184","journal-title":"Adv Anat Pathol"},{"key":"5336_CR19","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-018-0038-6","volume":"7","author":"G Nestal de Moraes","year":"2018","unstructured":"Nestal de Moraes G, Ji Z, Fan LYN, Yao S, Zona S, Sharrocks AD, Lam EW-F (2018) SUMOylation modulates FOXK2-mediated paclitaxel sensitivity in breast cancer cells. Oncogenesis 7:29. https:\/\/doi.org\/10.1038\/s41389-018-0038-6","journal-title":"Oncogenesis"},{"key":"5336_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11030393","volume":"11","author":"G Nestal de Moraes","year":"2019","unstructured":"Nestal de Moraes G, Carneiro LDT, Maia RC, Lam EW-F, Sharrocks AD (2019) FOXK2 transcription factor and its emerging roles in cancer. Cancers (Basel) 11:393. https:\/\/doi.org\/10.3390\/cancers11030393","journal-title":"Cancers (Basel)"},{"key":"5336_CR21","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.bbrc.2016.12.119","volume":"483","author":"Y Qian","year":"2017","unstructured":"Qian Y, Xia S, Feng Z (2017) Sox9 mediated transcriptional activation of FOXK2 is critical for colorectal cancer cells proliferation. Biochem Biophys Res Commun 483:475\u2013481. https:\/\/doi.org\/10.1016\/j.bbrc.2016.12.119","journal-title":"Biochem Biophys Res Commun"},{"issue":"Suppl 1","key":"5336_CR22","doi-asserted-by":"publisher","first-page":"34","DOI":"10.5146\/tjpath.2015.01313","volume":"31","author":"SD Sak","year":"2015","unstructured":"Sak SD (2015) Variants of papillary thyroid carcinoma: multiple faces of a familiar tumor. Turk Patoloji Derg 31(Suppl 1):34\u201347. https:\/\/doi.org\/10.5146\/tjpath.2015.01313","journal-title":"Turk Patoloji Derg"},{"key":"5336_CR23","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1038\/s41467-019-09418-0","volume":"10","author":"M Sakaguchi","year":"2019","unstructured":"Sakaguchi M, Cai W, Wang CH, Cederquist CT, Damasio M, Homan EP, Batista T, Ramirez AK, Gupta MK, Steger M, Wewer Albrechtsen NJ, Singh SK, Araki E, Mann M, Enerb\u00e4ck S, Kahn CR (2019) FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism. Nat Commun 10:1582. https:\/\/doi.org\/10.1038\/s41467-019-09418-0","journal-title":"Nat Commun"},{"key":"5336_CR24","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","volume":"74","author":"RL Siegel","year":"2024","unstructured":"Siegel RL, Giaquinto AN, Jemal A (2024) Cancer statistics, 2024. CA Cancer J Clin 74:12\u201349. https:\/\/doi.org\/10.3322\/caac.21820","journal-title":"CA Cancer J Clin"},{"key":"5336_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2021.102630","volume":"58","author":"H Sun","year":"2022","unstructured":"Sun H, Li Q, Song Z, Li C (2022) Hypoxia induction of SH2D3A triggers malignant progression of lung cancer. Stem Cell Res 58:102630. https:\/\/doi.org\/10.1016\/j.scr.2021.102630","journal-title":"Stem Cell Res"},{"key":"5336_CR26","doi-asserted-by":"publisher","first-page":"4045","DOI":"10.2147\/CMAR.S248560","volume":"12","author":"G Wang","year":"2020","unstructured":"Wang G, Zhang H, Li P (2020) Upregulation of hsa_circRNA_102958 indicates poor prognosis and promotes ovarian cancer progression through miR-1205\/SH2D3A axis. Cancer Manag Res 12:4045\u20134053. https:\/\/doi.org\/10.2147\/CMAR.S248560","journal-title":"Cancer Manag Res"},{"key":"5336_CR27","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1111\/jcmm.17107","volume":"26","author":"XW Wang","year":"2022","unstructured":"Wang XW, Guo QQ, Yu Y, Zhou TT, Zhang SY, Wang Z, Liu JW, Tang J, Jiang XY, Wang SS, Guo WD, Xu HD, Sun HY, Li ZW, Song XY, Zhao JG, Cao L (2022) The deacetylation of Foxk2 by Sirt1 reduces chemosensitivity to cisplatin. J Cell Mol Med 26:491\u2013506. https:\/\/doi.org\/10.1111\/jcmm.17107","journal-title":"J Cell Mol Med"},{"key":"5336_CR28","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2025.36.e34","volume":"36","author":"M Wu","year":"2025","unstructured":"Wu M, Liu R, Liu Y, Shen F, Zhao Y, Sheng X (2025) Role of HPV E7\/miR-143-3p\/SH2D3A pathway in regulating the occurrence and development of cervical cancer. J Gynecol Oncol 36:e34. https:\/\/doi.org\/10.3802\/jgo.2025.36.e34","journal-title":"J Gynecol Oncol"},{"key":"5336_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1376496","volume":"14","author":"X Xing","year":"2024","unstructured":"Xing X, Que X, Zheng S, Wang S, Song Q, Yao Y, Zhang P (2024) Emerging roles of FOXK2 in cancers and metabolic disorders. Front Oncol 14:1376496. https:\/\/doi.org\/10.3389\/fonc.2024.1376496","journal-title":"Front Oncol"},{"key":"5336_CR30","doi-asserted-by":"publisher","first-page":"10107","DOI":"10.18632\/aging.204448","volume":"14","author":"W Yang","year":"2022","unstructured":"Yang W, Chen H, Ma L et al (2022) A comprehensive analysis of the FOX family for predicting kidney renal clear cell carcinoma prognosis and the oncogenic role of FOXG1. Aging (Albany NY) 14:10107\u201310124. https:\/\/doi.org\/10.18632\/aging.204448","journal-title":"Aging (Albany NY)"}],"updated-by":[{"DOI":"10.1007\/s00210-026-05584-3","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000}}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05336-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05336-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05336-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:01:31Z","timestamp":1784775691000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05336-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,15]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["5336"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05336-3","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,15]]},"assertion":[{"value":"25 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: There was an inadvertent error in the description of the animal experimental ethics approval and experimental site.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2026","order":8,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":9,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00210-026-05584-3","URL":"https:\/\/doi.org\/10.1007\/s00210-026-05584-3","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All studies involving human participants were performed in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments. The study protocol was formally approved by the Ethics Committee of Tongling People's Hospital (Approval No. 2023KY-010). Written informed consent was obtained from all individual participants included in the study.All animal experimental procedures were conducted in strict accordance with the Guide for the Care and Use of Laboratory Animals. The protocols for mouse experiments were reviewed and approved by the Institutional Animal Care and Use Committee of Shanghai Rat & Mouse Biotech., Ltd. (Approval No. 2023-A005).","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}}]}}