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All efforts were made to minimize the number of animals used and their suffering, including proper anesthesia, refined experimental procedures, and humane endpoints.This study was carried out based on a written plan prepared in advance, which included research objectives, experimental design, animal grouping methods, observation indexes and data analysis strategies. However, the protocol was not registered on the public clinical trial or animal research registration platform. We will provide a copy of the proposal upon reasonable request.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}}]}}