{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:23:25Z","timestamp":1787664205443,"version":"build-2736575974"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s00210-026-05412-8","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:31:01Z","timestamp":1778643061000},"page":"16903-16914","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cynaroside reduces neutrophil extracellular trap formation and disease severity in a mouse model of asthma by inhibiting the COX-2\/TNF-alpha\/NF-kB axis"],"prefix":"10.1007","volume":"399","author":[{"given":"Daowen","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanxi","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"5412_CR1","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.1517\/14656566.8.17.3021","volume":"8","author":"SA Antoniu","year":"2007","unstructured":"Antoniu SA, Mihaescu T, Donner CF (2007) Pharmacotherapy of cough-variant asthma. Expert Opin Pharmacother 8:3021\u20133028. https:\/\/doi.org\/10.1517\/14656566.8.17.3021","journal-title":"Expert Opin Pharmacother"},{"key":"5412_CR2","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1146\/annurev-pathol-012414-040431","volume":"10","author":"L Broderick","year":"2015","unstructured":"Broderick L, De Nardo D, Franklin BS, Hoffman HM, Latz E (2015) The inflammasomes and autoinflammatory syndromes. Annu Rev Pathol 10:395\u2013424. https:\/\/doi.org\/10.1146\/annurev-pathol-012414-040431","journal-title":"Annu Rev Pathol"},{"key":"5412_CR3","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1152\/physrev.00023.2002","volume":"83","author":"AR Burns","year":"2003","unstructured":"Burns AR, Smith CW, Walker DC (2003) Unique structural features that influence neutrophil emigration into the lung. Physiol Rev 83:309\u2013336. https:\/\/doi.org\/10.1152\/physrev.00023.2002","journal-title":"Physiol Rev"},{"key":"5412_CR4","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s10753-021-01526-8","volume":"45","author":"F Chen","year":"2022","unstructured":"Chen F, Yu M, Zhong Y, Wang L, Huang H (2022a) Characteristics and role of neutrophil extracellular traps in asthma. Inflammation 45:6\u201313. https:\/\/doi.org\/10.1007\/s10753-021-01526-8","journal-title":"Inflammation"},{"key":"5412_CR5","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.2147\/jaa.S383128","volume":"15","author":"J Chen","year":"2022","unstructured":"Chen J, Lin W, Gu H, Ying K, Li T, Shao H (2022b) Study on the relationship between bronchoalveolar lavage fluid cell count, Th1\/Th2 cytokines and pulmonary function in patients with cough variant asthma. J Asthma Allergy 15:1713\u20131720. https:\/\/doi.org\/10.2147\/jaa.S383128","journal-title":"J Asthma Allergy"},{"key":"5412_CR6","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1097\/aci.0000000000000507","volume":"19","author":"Y Choi","year":"2019","unstructured":"Choi Y, Lee Y, Park HS (2019) Neutrophil activation in occupational asthma. Curr Opin Allergy Clin Immunol 19:81\u201385. https:\/\/doi.org\/10.1097\/aci.0000000000000507","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"5412_CR7","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/s2213-260(16)30232-6","volume":"4","author":"KF Chung","year":"2016","unstructured":"Chung KF (2016) Neutrophilic asthma: a distinct target for treatment? Lancet Respir Med 4:765\u2013767. https:\/\/doi.org\/10.1016\/s2213-260(16)30232-6","journal-title":"Lancet Respir Med"},{"key":"5412_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0251881","volume":"16","author":"A Crespo-Lessmann","year":"2021","unstructured":"Crespo-Lessmann A, Bernal S, Del R\u00edo E, Rojas E, Mart\u00ednez-Rivera C, Marina N, Pallar\u00e9s-Sanmart\u00edn A, Pascual S, Garc\u00eda-Rivero JL, Padilla-Galo A, Curto E, Cisneros C, Serrano J, Baiget M, Plaza V (2021) Association of the CFTR gene with asthma and airway mucus hypersecretion. PLoS One 16:e0251881. https:\/\/doi.org\/10.1371\/journal.pone.0251881","journal-title":"PLoS One"},{"key":"5412_CR9","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1164\/rccm.200912-1877OC","volume":"182","author":"CA Da Silva","year":"2010","unstructured":"Da Silva CA, Pochard P, Lee CG, Elias JA (2010) Chitin particles are multifaceted immune adjuvants. Am J Respir Crit Care Med 182:1482\u20131491. https:\/\/doi.org\/10.1164\/rccm.200912-1877OC","journal-title":"Am J Respir Crit Care Med"},{"key":"5412_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174522","volume":"911","author":"J Feng","year":"2021","unstructured":"Feng J, Liu Z, Chen H, Zhang M, Ma X, Han Q, Lu D, Wang C (2021) Protective effect of cynaroside on sepsis-induced multiple organ injury through Nrf2\/HO-1-dependent macrophage polarization. Eur J Pharmacol 911:174522. https:\/\/doi.org\/10.1016\/j.ejphar.2021.174522","journal-title":"Eur J Pharmacol"},{"key":"5412_CR11","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1038\/s41593-024-01712-5","volume":"27","author":"N Gannot","year":"2024","unstructured":"Gannot N, Li X, Phillips CD, Ozel AB, Uchima Koecklin KH, Lloyd JP, Zhang L, Emery K, Stern T, Li JZ, Li P (2024) A vagal-brainstem interoceptive circuit for cough-like defensive behaviors in mice. Nat Neurosci 27:1734\u20131744. https:\/\/doi.org\/10.1038\/s41593-024-01712-5","journal-title":"Nat Neurosci"},{"key":"5412_CR12","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1164\/rccm.202009-3713OC","volume":"203","author":"AT Hastie","year":"2021","unstructured":"Hastie AT, Mauger DT, Denlinger LC, Coverstone A, Castro M, Erzurum S, Jarjour N, Levy BD, Meyers DA, Moore WC, Phillips BR, Wenzel SE, Fahy JV, Israel E, Bleecker ER (2021) Mixed sputum granulocyte longitudinal impact on lung function in the Severe Asthma Research Program. Am J Respir Crit Care Med 203:882\u2013892. https:\/\/doi.org\/10.1164\/rccm.202009-3713OC","journal-title":"Am J Respir Crit Care Med"},{"key":"5412_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114482","volume":"281","author":"Q He","year":"2021","unstructured":"He Q, Liu C, Shen L, Zeng L, Wang T, Sun J, Zhou X, Wan J (2021) Theory of the exterior-interior relationship between the lungs and the large intestine to explore the mechanism of Eriobotrya japonica leaf water extract in the treatment of cough variant asthma. J Ethnopharmacol 281:114482. https:\/\/doi.org\/10.1016\/j.jep.2021.114482","journal-title":"J Ethnopharmacol"},{"key":"5412_CR14","doi-asserted-by":"publisher","first-page":"229","DOI":"10.4196\/kjpp.2024.28.3.229","volume":"28","author":"Q He","year":"2024","unstructured":"He Q, Liu W, Ma X, Li H, Feng W, Lu X, Li Y, Chen Z (2024) Pectolinarigenin ameliorated airway inflammation and airway remodeling to exhibit antitussive effect. Korean J Physiol Pharmacol 28:229\u2013237. https:\/\/doi.org\/10.4196\/kjpp.2024.28.3.229","journal-title":"Korean J Physiol Pharmacol"},{"key":"5412_CR15","doi-asserted-by":"publisher","first-page":"5621","DOI":"10.12659\/msm.915080","volume":"25","author":"S Hua","year":"2019","unstructured":"Hua S, Liu F, Wang M (2019) Emodin alleviates the airway inflammation of cough variant asthma in mice by regulating the Notch pathway. Med Sci Monit 25:5621\u20135629. https:\/\/doi.org\/10.12659\/msm.915080","journal-title":"Med Sci Monit"},{"key":"5412_CR16","doi-asserted-by":"publisher","unstructured":"Jackson DJ, Bacharier LB, Mauger DT, Boehmer S, Beigelman A, Chmiel JF, Fitzpatrick AM, Gaffin JM, Morgan WJ, Peters SP, Phipatanakul W, Sheehan WJ, Cabana MD, Holguin F, Martinez FD, Pongracic JA, Baxi SN, Benson M, Blake K, Covar R, Gentile DA, Israel E, Krishnan JA, Kumar HV, Lang JE, Lazarus SC, Lima JJ, Long D, Ly N, Marbin J, Moy JN, Myers RE, Olin JT, Raissy HH, Robison RG, Ross K, Sorkness CA, Lemanske RF Jr. (2018) Quintupling inhaled glucocorticoids to prevent childhood asthma exacerbations. N Engl J Med 378:891\u2013901. https:\/\/doi.org\/10.1056\/NEJMoa1710988","DOI":"10.1056\/NEJMoa1710988"},{"key":"5412_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.116013","volume":"307","author":"H Jiang","year":"2023","unstructured":"Jiang H, Bai Z, Ou Y, Liu H, Si Z, Liu Y, Liu X, Liu X, Zhang Z, Tan N (2023) \u03b2-Hydroxybutyric acid upregulated by Suhuang antitussive capsule ameliorates cough variant asthma through GSK3\u03b2\/AMPK-Nrf2 signal axis. J Ethnopharmacol 307:116013. https:\/\/doi.org\/10.1016\/j.jep.2022.116013","journal-title":"J Ethnopharmacol"},{"key":"5412_CR18","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1248\/bpb.32.1500","volume":"32","author":"M Jin","year":"2009","unstructured":"Jin M, Yang JH, Lee E, Lu Y, Kwon S, Son KH, Son JK, Chang HW (2009) Antiasthmatic activity of luteolin-7-O-glucoside from Ailanthus altissima through the downregulation of T helper 2 cytokine expression and inhibition of prostaglandin E2 production in an ovalbumin-induced asthma model. Biol Pharm Bull 32:1500\u20131503. https:\/\/doi.org\/10.1248\/bpb.32.1500","journal-title":"Biol Pharm Bull"},{"key":"5412_CR19","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nm.4294","volume":"23","author":"SK Jorch","year":"2017","unstructured":"Jorch SK, Kubes P (2017) An emerging role for neutrophil extracellular traps in noninfectious disease. Nat Med 23:279\u2013287. https:\/\/doi.org\/10.1038\/nm.4294","journal-title":"Nat Med"},{"key":"5412_CR20","doi-asserted-by":"publisher","unstructured":"Krishnamoorthy N, Douda DN, Br\u00fcggemann TR, Ricklefs I, Duvall MG, Abdulnour RE, Martinod K, Tavares L, Wang X, Cernadas M, Israel E, Mauger DT, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Wenzel S, Dunican E, Fahy JV, Irimia D, Wagner DD, Levy BD (2018) Neutrophil cytoplasts induce T(H)17 differentiation and skew inflammation toward neutrophilia in severe asthma. Sci Immunol 3. https:\/\/doi.org\/10.1126\/sciimmunol.aao4747","DOI":"10.1126\/sciimmunol.aao4747"},{"key":"5412_CR21","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1164\/rccm.201810-1869OC","volume":"199","author":"ME Lachowicz-Scroggins","year":"2019","unstructured":"Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefran\u00e7ais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Fajt ML, Wenzel SE, Israel E, Levy BD, Fahy JV (2019) Extracellular DNA, neutrophil extracellular traps, and inflammasome activation in severe asthma. Am J Respir Crit Care Med 199:1076\u20131085. https:\/\/doi.org\/10.1164\/rccm.201810-1869OC","journal-title":"Am J Respir Crit Care Med"},{"key":"5412_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.807385","volume":"8","author":"K Lai","year":"2021","unstructured":"Lai K, Zhan W, Wu F, Zhang Y, Lin L, Li W, Yi F, Jiang Z, Dai Y, Li S, Lin J, Yuan Y, Jiang Y, Qiu C, Zhao L, Chen M, Qiu Z, Li H, Chen R, Luo W, Xie J, Guo C, Jiang M, Yang X, Shi G, Sun D, Chen R, Chung KF, Shen H, Zhong N (2021) Clinical and inflammatory characteristics of the Chinese APAC cough variant asthma cohort. Front Med (Lausanne) 8:807385. https:\/\/doi.org\/10.3389\/fmed.2021.807385","journal-title":"Front Med (Lausanne)"},{"key":"5412_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2020.104944","volume":"120","author":"SA Lee","year":"2020","unstructured":"Lee SA, Park BR, Moon SM, Shin SH, Kim JS, Kim DK, Kim CS (2020) Cynaroside protects human periodontal ligament cells from lipopolysaccharide-induced damage and inflammation through suppression of NF-\u03baB activation. Arch Oral Biol 120:104944. https:\/\/doi.org\/10.1016\/j.archoralbio.2020.104944","journal-title":"Arch Oral Biol"},{"key":"5412_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.176271","volume":"963","author":"W Li","year":"2024","unstructured":"Li W, Wang X, Chen Y, Ding Y, Ling X, Yuan B, Tao J (2024) Luteolin-7-O-glucoside promotes macrophage release of IFN-\u03b2 by maintaining mitochondrial function and corrects the disorder of glucose metabolism during RSV infection. Eur J Pharmacol 963:176271. https:\/\/doi.org\/10.1016\/j.ejphar.2023.176271","journal-title":"Eur J Pharmacol"},{"key":"5412_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115501","volume":"167","author":"X Ma","year":"2023","unstructured":"Ma X, Zhang L, Gao F, Jia W, Li C (2023) Salvia miltiorrhiza and tanshinone IIA reduce endothelial inflammation and atherosclerotic plaque formation through inhibiting COX-2. Biomed Pharmacother 167:115501. https:\/\/doi.org\/10.1016\/j.biopha.2023.115501","journal-title":"Biomed Pharmacother"},{"key":"5412_CR26","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1007\/s00436-016-4941-5","volume":"115","author":"P Maksimov","year":"2016","unstructured":"Maksimov P, Hermosilla C, Kleinertz S, Hirzmann J, Taubert A (2016) Besnoitia besnoiti infections activate primary bovine endothelial cells and promote PMN adhesion and NET formation under physiological flow condition. Parasitol Res 115:1991\u20132001. https:\/\/doi.org\/10.1007\/s00436-016-4941-5","journal-title":"Parasitol Res"},{"key":"5412_CR27","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1182\/blood-2010-06-290171","volume":"117","author":"KD Metzler","year":"2011","unstructured":"Metzler KD, Fuchs TA, Nauseef WM, Reumaux D, Roesler J, Schulze I, Wahn V, Papayannopoulos V, Zychlinsky A (2011) Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity. Blood 117:953\u2013959. https:\/\/doi.org\/10.1182\/blood-2010-06-290171","journal-title":"Blood"},{"key":"5412_CR28","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01136-2019","author":"AH Morice","year":"2020","unstructured":"Morice AH, Millqvist E, Bieksiene K, Birring SS, Dicpinigaitis P, Domingo Ribas C, Hilton Boon M, Kantar A, Lai K, McGarvey L, Rigau D, Satia I, Smith J, Song WJ, Tonia T, van den Berg JWK, van Manen MJG, Zacharasiewicz A (2020) ERS guidelines on the diagnosis and treatment of chronic cough in adults and children. Eur Respir J. https:\/\/doi.org\/10.1183\/13993003.01136-2019","journal-title":"Eur Respir J"},{"key":"5412_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116637","volume":"314","author":"V Nguyen","year":"2023","unstructured":"Nguyen V, Zhang Q, Pan F, Jin Q, Sun M, Tangthianchaichana J, Du S, Lu Y (2023) Zi-Su-Zi decoction improves airway hyperresponsiveness in cough-variant asthma rat model through PI3K\/AKT1\/mTOR, JAK2\/STAT3 and HIF-1\u03b1\/NF-\u03baB signaling pathways. J Ethnopharmacol 314:116637. https:\/\/doi.org\/10.1016\/j.jep.2023.116637","journal-title":"J Ethnopharmacol"},{"key":"5412_CR30","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.2147\/ijgm.S455872","volume":"17","author":"Y Niu","year":"2024","unstructured":"Niu Y, Cao M, Li S, Mo J, Zhu Z, Wang H (2024) The effects of budesonide inhalation treatment on the expression levels of serum IL-6, TGF-\u03b21, and IgE and pulmonary function in patients with cough variant asthma and an evaluation of treatment efficacy. Int J Gen Med 17:1253\u20131261. https:\/\/doi.org\/10.2147\/ijgm.S455872","journal-title":"Int J Gen Med"},{"key":"5412_CR31","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/cea.12859","volume":"47","author":"DL Pham","year":"2017","unstructured":"Pham DL, Ban GY, Kim SH, Shin YS, Ye YM, Chwae YJ, Park HS (2017) Neutrophil autophagy and extracellular DNA traps contribute to airway inflammation in severe asthma. Clin Exp Allergy 47:57\u201370. https:\/\/doi.org\/10.1111\/cea.12859","journal-title":"Clin Exp Allergy"},{"key":"5412_CR32","doi-asserted-by":"publisher","first-page":"595","DOI":"10.2147\/jir.S343411","volume":"15","author":"A Rybka-Fraczek","year":"2022","unstructured":"Rybka-Fraczek A, Dabrowska M, Grabczak EM, Bialek-Gosk K, Klimowicz K, Truba O, Nejman-Gryz P, Paplinska-Goryca M, Krenke R (2022) Inflammatory phenotypes of cough variant asthma as response predictors to anti-asthmatic therapy. J Inflamm Res 15:595\u2013602. https:\/\/doi.org\/10.2147\/jir.S343411","journal-title":"J Inflamm Res"},{"key":"5412_CR33","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jpsychores.2015.03.011","volume":"79","author":"N Saito","year":"2015","unstructured":"Saito N, Itoga M, Tamaki M, Yamamoto A, Kayaba H (2015) Cough variant asthma patients are more depressed and anxious than classic asthma patients. J Psychosom Res 79:18\u201326. https:\/\/doi.org\/10.1016\/j.jpsychores.2015.03.011","journal-title":"J Psychosom Res"},{"key":"5412_CR34","doi-asserted-by":"publisher","first-page":"512","DOI":"10.3109\/02770903.2014.975358","volume":"52","author":"E Tagaya","year":"2015","unstructured":"Tagaya E, Kondo M, Kirishi S, Kawagoe M, Kubota N, Tamaoki J (2015) Effects of regular treatment with combination of salmeterol\/fluticasone propionate and salmeterol alone in cough variant asthma. J Asthma 52:512\u2013518. https:\/\/doi.org\/10.3109\/02770903.2014.975358","journal-title":"J Asthma"},{"key":"5412_CR35","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1111\/j.1365-2222.2007.02848.x","volume":"37","author":"M Takemura","year":"2007","unstructured":"Takemura M, Niimi A, Matsumoto H, Ueda T, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Mishima M (2007) Atopic features of cough variant asthma and classic asthma with wheezing. Clin Exp Allergy 37:1833\u20131839. https:\/\/doi.org\/10.1111\/j.1365-2222.2007.02848.x","journal-title":"Clin Exp Allergy"},{"key":"5412_CR36","doi-asserted-by":"publisher","first-page":"98","DOI":"10.26442\/00403660.2020.03.000404","volume":"92","author":"MO Uryasjev","year":"2020","unstructured":"Uryasjev MO, Ponomareva IV, Bhar M, Glotov SI (2020) [The cough variant asthma]. Ter Arkh 92:98\u2013101. https:\/\/doi.org\/10.26442\/00403660.2020.03.000404","journal-title":"Ter Arkh"},{"key":"5412_CR37","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1084\/jem.20042311","volume":"201","author":"LS van Rijt","year":"2005","unstructured":"van Rijt LS, Jung S, Kleinjan A, Vos N, Willart M, Duez C, Hoogsteden HC, Lambrecht BN (2005) In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J Exp Med 201:981\u2013991. https:\/\/doi.org\/10.1084\/jem.20042311","journal-title":"J Exp Med"},{"key":"5412_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.867516","volume":"13","author":"Y Wang","year":"2022","unstructured":"Wang Y, Liu F, Chen L, Fang C, Li S, Yuan S, Qian X, Yin Y, Yu B, Fu B, Zhang X, Li Y (2022) Neutrophil extracellular traps (NETs) promote non-small cell lung cancer metastasis by suppressing lncRNA MIR503HG to activate the NF-\u03baB\/NLRP3 inflammasome pathway. Front Immunol 13:867516. https:\/\/doi.org\/10.3389\/fimmu.2022.867516","journal-title":"Front Immunol"},{"key":"5412_CR39","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aau0112","author":"M Wills-Karp","year":"2018","unstructured":"Wills-Karp M (2018) Neutrophil ghosts worsen asthma. Sci Immunol. https:\/\/doi.org\/10.1126\/sciimmunol.aau0112","journal-title":"Sci Immunol"},{"key":"5412_CR40","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-022-02209-0","volume":"23","author":"M Xia","year":"2022","unstructured":"Xia M, Xu F, Ni H, Wang Q, Zhang R, Lou Y, Zhou J (2022) Neutrophil activation and NETosis are the predominant drivers of airway inflammation in an OVA\/CFA\/LPS induced murine model. Respir Res 23:289. https:\/\/doi.org\/10.1186\/s12931-022-02209-0","journal-title":"Respir Res"},{"key":"5412_CR41","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/s41586-020-2394-6","volume":"583","author":"L Yang","year":"2020","unstructured":"Yang L, Liu Q, Zhang X, Liu X, Zhou B, Chen J, Huang D, Li J, Li H, Chen F, Liu J, Xing Y, Chen X, Su S, Song E (2020) DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25. Nature 583:133\u2013138. https:\/\/doi.org\/10.1038\/s41586-020-2394-6","journal-title":"Nature"},{"key":"5412_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2020.101903","volume":"61","author":"F Yi","year":"2020","unstructured":"Yi F, Han L, Liu B, Zhang X, Xue Y, Luo W, Chen Q, Lai K (2020) Determinants of response to bronchodilator in patients with cough variant asthma- a randomized, single-blinded, placebo-controlled study. Pulm Pharmacol Ther 61:101903. https:\/\/doi.org\/10.1016\/j.pupt.2020.101903","journal-title":"Pulm Pharmacol Ther"},{"key":"5412_CR43","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1186\/s12931-022-02114-6","volume":"23","author":"F Yi","year":"2022","unstructured":"Yi F, Zhan C, Liu B, Li H, Zhou J, Tang J, Peng W, Luo W, Chen Q, Lai K (2022) Effects of treatment with montelukast alone, budesonide\/formoterol alone and a combination of both in cough variant asthma. Respir Res 23:279. https:\/\/doi.org\/10.1186\/s12931-022-02114-6","journal-title":"Respir Res"},{"key":"5412_CR44","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.jaci.2023.04.017","volume":"152","author":"W Zhan","year":"2023","unstructured":"Zhan W, Wu F, Zhang Y, Lin L, Li W, Luo W, Yi F, Dai Y, Li S, Lin J, Yuan Y, Qiu C, Jiang Y, Zhao L, Chen M, Qiu Z, Chen R, Xie J, Guo C, Jiang M, Yang X, Shi G, Sun D, Chen R, Zhong N, Shen H, Lai K (2023) Identification of cough-variant asthma phenotypes based on clinical and pathophysiologic data. J Allergy Clin Immunol 152:622\u2013632. https:\/\/doi.org\/10.1016\/j.jaci.2023.04.017","journal-title":"J Allergy Clin Immunol"},{"key":"5412_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/srep21515","volume":"6","author":"C Zhang","year":"2016","unstructured":"Zhang C, Zhang LH, Wu YF, Lai TW, Wang HS, Xiao H, Che LQ, Ying SM, Li W, Chen ZH, Shen HH (2016) Suhuang antitussive capsule at lower doses attenuates airway hyperresponsiveness, inflammation, and remodeling in a murine model of chronic asthma. Sci Rep 6:21515. https:\/\/doi.org\/10.1038\/srep21515","journal-title":"Sci Rep"},{"key":"5412_CR46","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1170","volume":"13","author":"H Zhang","year":"2023","unstructured":"Zhang H, Wang Y, Qu M, Li W, Wu D, Cata JP, Miao C (2023) Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis. Clin Transl Med 13:e1170. https:\/\/doi.org\/10.1002\/ctm2.1170","journal-title":"Clin Transl Med"},{"key":"5412_CR47","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-023-00935-4","author":"J Zheng","year":"2023","unstructured":"Zheng J, Yang H, Liu C, Zhang R, Yibulayimu N, Jin X (2023) Ethanol extract of Anacyclus pyrethrum root ameliorates cough-variant asthma through the TLR4\/NF-\u03baB pathway and Wnt\/\u03b2-catenin pathway. Mol Biotechnol. https:\/\/doi.org\/10.1007\/s12033-023-00935-4","journal-title":"Mol Biotechnol"},{"key":"5412_CR48","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1186\/s12931-022-02104-8","volume":"23","author":"J Zhou","year":"2022","unstructured":"Zhou J, Yi F, Wu F, Xu P, Chen M, Shen H, Lin L, Zhang Y, Li S, Wu C, Yuan Y, Wang G, Ye X, Zhang P, Tang H, Ma Q, Huang L, Qiu Z, Deng H, Qiu C, Shi G, Pan J, Luo W, Chung KF, Zhong N, Lai K (2022) Characteristics of different asthma phenotypes associated with cough: a prospective, multicenter survey in China. Respir Res 23:243. https:\/\/doi.org\/10.1186\/s12931-022-02104-8","journal-title":"Respir Res"},{"key":"5412_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116425","volume":"173","author":"Y Zhou","year":"2024","unstructured":"Zhou Y, Huang Y, Ye W, Chen Z, Yuan Z (2024) Cynaroside improved depressive-like behavior in CUMS mice by suppressing microglial inflammation and ferroptosis. Biomed Pharmacother 173:116425. https:\/\/doi.org\/10.1016\/j.biopha.2024.116425","journal-title":"Biomed Pharmacother"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05412-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05412-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05412-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:03:02Z","timestamp":1787662982000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05412-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["5412"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05412-8","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,13]]},"assertion":[{"value":"4 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. All animal procedures were approved by the Chinese Academy of Sciences Committee on Biosafety and Ethics and Laboratory Animal Management, Institute of Biophysics, and conformed to the standards outlined in the Guide for the Ethical Care and Use of Laboratory Animals (No. ABSL-2\u20142024044).","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}}]}}