{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:30:45Z","timestamp":1787671845379,"version":"build-2736575974"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s00210-026-05429-z","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T02:21:53Z","timestamp":1779502913000},"page":"17425-17449","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and characterization of a reserpine-induced mouse model of depression: An integrated in-vivo and in-silico approach"],"prefix":"10.1007","volume":"399","author":[{"given":"Karuna","family":"Gautam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukala","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"5429_CR1","doi-asserted-by":"publisher","first-page":"S112","DOI":"10.1590\/1516-4446-2013-1098","volume":"35","author":"HM Abelaira","year":"2013","unstructured":"Abelaira HM, R\u00e9us GZ, Quevedo J (2013) Animal models as tools to study the pathophysiology of depression. Braz J Psychiatry 35:S112\u2013S120","journal-title":"Braz J Psychiatry"},{"issue":"4","key":"5429_CR2","doi-asserted-by":"publisher","first-page":"942","DOI":"10.3390\/antiox12040942","volume":"12","author":"AEK Ait Tayeb","year":"2023","unstructured":"Ait Tayeb AEK, Poinsignon V, Chappell K, Bouligand J, Becquemont L, Verstuyft C (2023) Major depressive disorder and oxidative stress: a review of peripheral and genetic biomarkers according to clinical characteristics and disease stages. Antioxidants (Basel) 12(4):942","journal-title":"Antioxidants (Basel)"},{"issue":"10","key":"5429_CR3","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1351\/pac197951102157","volume":"51","author":"J Bartos","year":"1979","unstructured":"Bartos J, Pesez M (1979) Colorimetric and fluorimetric determination of steroids. Pure Appl Chem 51(10):2157\u20132159","journal-title":"Pure Appl Chem"},{"issue":"1","key":"5429_CR4","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3390\/diagnostics11010123","volume":"11","author":"M Becker","year":"2021","unstructured":"Becker M, Pinhasov A, Ornoy A (2021) Animal models of depression: what can they teach us about the human disease? Diagnostics (Basel) 11(1):123","journal-title":"Diagnostics (Basel)"},{"key":"5429_CR5","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1016\/j.neuroscience.2007.04.002","volume":"146","author":"A Bilska","year":"2007","unstructured":"Bilska A, Dubiel M, Soko\u0142owska-Jezewicz M, Lorenc-Koci E, W\u0142odek L (2007) Alpha-lipoic acid differently affects the reserpine-induced oxidative stress in the striatum and prefrontal cortex of rat brain. Neuroscience 146:1758\u20131771","journal-title":"Neuroscience"},{"issue":"9","key":"5429_CR6","doi-asserted-by":"publisher","first-page":"860","DOI":"10.3390\/antiox9090860","volume":"9","author":"D Bode","year":"2020","unstructured":"Bode D, Wen Y, Hegemann N et al (2020) Oxidative stress and inflammatory modulation of Ca2+ handling in metabolic HFpEF-related left atrial cardiomyopathy. Antioxidants (Basel) 9(9):860","journal-title":"Antioxidants (Basel)"},{"key":"5429_CR7","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.physbeh.2013.05.012","volume":"118","author":"OV Bogdanova","year":"2013","unstructured":"Bogdanova OV, Kanekar S, D\u2019Anci KE, Renshaw PF (2013) Factors influencing behavior in the forced swim test. Physiol Behav 118:227\u2013239","journal-title":"Physiol Behav"},{"issue":"1","key":"5429_CR8","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s11920-010-0165-z","volume":"13","author":"A Campayo","year":"2011","unstructured":"Campayo A, G\u00f3mez-Biel CH, Lobo A (2011) Diabetes and depression. Curr Psychiatry Rep 13(1):26\u201330","journal-title":"Curr Psychiatry Rep"},{"key":"5429_CR9","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/159015","volume":"2015","author":"CY Chang","year":"2015","unstructured":"Chang CY, Guo HR, Tsai WC et al (2015) Subchronic arsenic exposure induces anxiety-like behaviors in normal mice and enhances depression-like behaviors in the chemically induced mouse model of depression. BioMed Res Int 2015:159015","journal-title":"BioMed Res Int"},{"issue":"8","key":"5429_CR10","doi-asserted-by":"publisher","first-page":"375","DOI":"10.3390\/md22080375","volume":"22","author":"J Chen","year":"2024","unstructured":"Chen J, Li X, Tao J, Luo L (2024) Identification of marine-derived SLC7A11 inhibitors: molecular docking, structure-based virtual screening, cytotoxicity prediction, and molecular dynamics simulation. Mar Drugs 22(8):375","journal-title":"Mar Drugs"},{"issue":"1","key":"5429_CR11","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1292\/jvms.22-0103","volume":"85","author":"S Chiba","year":"2023","unstructured":"Chiba S, Numakawa T, Murata T, Kawaminami M, Himi T (2023) Enhanced social reward response and anxiety-like behavior with downregulation of nucleus accumbens glucocorticoid receptor in BALB\/c mice. J Vet Med Sci 85(1):30\u201339","journal-title":"J Vet Med Sci"},{"key":"5429_CR12","unstructured":"Claiborne AL (1985) Catalase activity. In: Handbook of methods for oxygen radical research, p 383"},{"key":"5429_CR13","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.redox.2018.01.008","volume":"15","author":"JN Cobley","year":"2018","unstructured":"Cobley JN, Fiorello ML, Bailey DM (2018) 13 reasons why the brain is susceptible to oxidative stress. Red Biol 15:490\u2013503","journal-title":"Red Biol"},{"issue":"1","key":"5429_CR14","first-page":"30","volume":"9","author":"L Cui","year":"2024","unstructured":"Cui L, Li S, Wang S et al (2024) Major depressive disorder: hypothesis, mechanism, prevention and treatment. Sig Transd Targ Ther 9(1):30","journal-title":"Sig Transd Targ Ther"},{"key":"5429_CR15","unstructured":"Das K, Samanta L, Chainy GB (2000) A modified spectrophotometric assay of superoxide dismutase using nitrite formation by superoxide radicals. Indian J Biochem Biophys 37(3):201\u20134"},{"key":"5429_CR16","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s10565-008-9072-z","volume":"25","author":"A Dhawan","year":"2009","unstructured":"Dhawan A, Bajpayee M, Parmar D (2009) Comet assay: a reliable tool for the assessment of DNA damage in different models. Cell Biol Toxicol 25:5\u201332","journal-title":"Cell Biol Toxicol"},{"key":"5429_CR17","doi-asserted-by":"crossref","unstructured":"Diksha, Singh L (2024) Glycitein prevents reserpine-induced depression and associated comorbidities in mice: modulation of lipid peroxidation and TNF-\u03b1 levels. Naunyn-Schmiedeberg's Arch Pharmacol 397(8):6153\u20136163","DOI":"10.1007\/s00210-024-03007-9"},{"issue":"1","key":"5429_CR18","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/s41398-020-0808-8","volume":"10","author":"X Du","year":"2020","unstructured":"Du X, Yin M, Yuan L et al (2020) Reduction of depression-like behavior in rat model induced by ShRNA targeting norepinephrine transporter in locus coeruleus. Transl Psych 10(1):130","journal-title":"Transl Psych"},{"issue":"3","key":"5429_CR19","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nm.4050","volume":"22","author":"RS Duman","year":"2016","unstructured":"Duman RS, Aghajanian GK, Sanacora G, Krystal JH (2016) Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nat Med 22(3):238\u2013249","journal-title":"Nat Med"},{"issue":"4","key":"5429_CR20","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.clinbiochem.2003.11.015","volume":"37","author":"O Erel","year":"2004","unstructured":"Erel O (2004) A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Bioch 37(4):277\u2013285","journal-title":"Clin Bioch"},{"issue":"12","key":"5429_CR21","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/j.clinbiochem.2005.08.008","volume":"38","author":"O Erel","year":"2005","unstructured":"Erel O (2005) A new automated colorimetric method for measuring total oxidant status. Clin Bioch 38(12):1103\u20131111","journal-title":"Clin Bioch"},{"issue":"6","key":"5429_CR22","doi-asserted-by":"publisher","first-page":"2630","DOI":"10.1007\/s12011-023-03849-z","volume":"202","author":"HM Fahmy","year":"2024","unstructured":"Fahmy HM, Aboalasaad FA, Mohamed AS et al (2024) Evaluation of the therapeutic effect of curcumin-conjugated zinc oxide nanoparticles on reserpine-induced depression in Wistar rats. Biol Trace Elem Res 202(6):2630\u20132644","journal-title":"Biol Trace Elem Res"},{"issue":"7","key":"5429_CR23","doi-asserted-by":"publisher","first-page":"13384","DOI":"10.3390\/molecules200713384","volume":"20","author":"LG Ferreira","year":"2015","unstructured":"Ferreira LG, Dos Santos RN, Oliva G, Andricopulo AD (2015) Molecular docking and structure-based drug design strategies. Molecules 20(7):13384\u201313421","journal-title":"Molecules"},{"key":"5429_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2021.113323","volume":"409","author":"PJ Fitzgerald","year":"2021","unstructured":"Fitzgerald PJ, Hale PJ, Ghimire A, Watson BO (2021) Multiple cholinesterase inhibitors have antidepressant-like properties in the mouse forced swim test. Behav Brain Res 409:113323","journal-title":"Behav Brain Res"},{"key":"5429_CR25","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/S0076-6879(07)00823-3","volume":"440","author":"D Giustarini","year":"2008","unstructured":"Giustarini D, Rossi R, Milzani A, Dalle-Donne I (2008) Nitrite and nitrate measurement by Griess reagent in human plasma: evaluation of interferences and standardization. Methods Enzymol 440:361\u2013380","journal-title":"Methods Enzymol"},{"issue":"2","key":"5429_CR26","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/j.2042-7158.1993.tb03698.x","volume":"45","author":"Z Gorka","year":"1993","unstructured":"Gorka Z, Adamik P (1993) The effect of reserpine and stress on feeding behaviour in the light and dark phases of the diurnal cycle in rats. J Pharm Pharmacol 45(2):137\u2013138","journal-title":"J Pharm Pharmacol"},{"key":"5429_CR27","doi-asserted-by":"crossref","unstructured":"Govindarajulu M, Shankar T, Patel S, Fabbrini M, Manohar A, Ramesh S et al (2021) Reserpine-induced depression and other neurotoxicity: amonoaminergic hypothesis. In: Medicinal herbs and fungi: neurotoxicity vs. neuroprotection, pp 293\u2013313","DOI":"10.1007\/978-981-33-4141-8_12"},{"issue":"2","key":"5429_CR28","volume":"3","author":"R Greenwood","year":"2018","unstructured":"Greenwood R, Zhao J, Ludrick B et al (2018) A practical animal model for depression by reserpine-administered mice. Theranostics Brain Disord 3(2):555609","journal-title":"Theranostics Brain Disord"},{"key":"5429_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.591161","volume":"7","author":"J Han","year":"2021","unstructured":"Han J, Nepal P, Odelade A et al (2021) High-fat diet-induced weight gain, behavioral deficits, and dopamine changes in young C57BL\/6J mice. Front Nutr 7:591161","journal-title":"Front Nutr"},{"key":"5429_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2024.137851","volume":"835","author":"H Harada","year":"2024","unstructured":"Harada H, Mori M, Murata Y et al (2024) Divergent effects of chronic continuous and intermittent social defeat stress on emotional behaviors: impact on phosphorylated CREB and BDNF protein levels in the rat hippocampus. Neurosci Lett 835:137851","journal-title":"Neurosci Lett"},{"key":"5429_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1130989","volume":"14","author":"S Hassamal","year":"2023","unstructured":"Hassamal S (2023) Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories. Front Psychiatry 14:1130989","journal-title":"Front Psychiatry"},{"key":"5429_CR32","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s11011-017-0167-1","volume":"33","author":"D He","year":"2018","unstructured":"He D, Sai X, Wang N et al (2018) Camellia euphlebia exerts its antidepressant-like effect via modulation of the hypothalamic-pituitary-adrenal axis and brain monoaminergic systems. Metab Brain Dis 33:301\u2013312","journal-title":"Metab Brain Dis"},{"key":"5429_CR33","doi-asserted-by":"crossref","unstructured":"Hedgecock T, Phillips A, Ludrick B, Golden T, Wu N (2019) Molecular mechanisms and applications of a reserpine-induced rodent model [molecular mechanisms and applications of a reserpine-induced rodent model]. SSR Inst Int J Life Sci 5(1)","DOI":"10.21276\/SSR-IIJLS.2019.5.1.8"},{"key":"5429_CR34","unstructured":"Ikram H, Haleem DJ (2017) Repeated treatment with reserpine as a progressive animal model of depression. Pak J Pharm Sci 30(3)"},{"key":"5429_CR35","first-page":"555","volume":"32","author":"H Ikram","year":"2019","unstructured":"Ikram H, Haleem DJ (2019) Repeated treatment with a low dose of reserpine as a progressive model of Parkinson\u2019s dementia. Pak J Pharm Sci 32:555\u2013562","journal-title":"Pak J Pharm Sci"},{"issue":"1","key":"5429_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51960-z","volume":"15","author":"D Im","year":"2024","unstructured":"Im D, Jormakka M, Juge N et al (2024) Neurotransmitter recognition by human vesicular monoamine transporter 2. Nat Commun 15(1):7661","journal-title":"Nat Commun"},{"issue":"3","key":"5429_CR37","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1177\/02698811231161813","volume":"37","author":"S Jauhar","year":"2023","unstructured":"Jauhar S, Cowen PJ, Browning M (2023) Fifty years on: serotonin and depression. J Psychopharmacol 37(3):237\u2013241","journal-title":"J Psychopharmacol"},{"issue":"8","key":"5429_CR38","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24086888","volume":"24","author":"M Jazvin\u0161\u0107ak Jembrek","year":"2023","unstructured":"Jazvin\u0161\u0107ak Jembrek M, Or\u0161oli\u0107 N, Karlovi\u0107 D, Peitl V (2023) Flavonols in action: targeting oxidative stress and neuroinflammation in major depressive disorder. Int J Mol Sci 24(8):6888","journal-title":"Int J Mol Sci"},{"issue":"10","key":"5429_CR39","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.3390\/ph15101203","volume":"15","author":"Y Jiang","year":"2022","unstructured":"Jiang Y, Zou D, Li Y et al (2022) Monoamine neurotransmitters control basic emotions and affect major depressive disorders. Pharmaceuticals 15(10):1203","journal-title":"Pharmaceuticals"},{"issue":"2","key":"5429_CR40","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s12291-022-01045-9","volume":"38","author":"GVK Khushboo","year":"2023","unstructured":"Khushboo GVK, Sharma B (2023) Hepatoprotective Effect of Ethanolic Extract of Garlic Against Reserpine Induced Toxicity in Wistar Rats. Ind J Clin Biochm 38(2):251\u2013261","journal-title":"Ind J Clin Biochm"},{"issue":"4","key":"5429_CR41","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1111\/bpa.12253","volume":"25","author":"AH Le\u00e3o","year":"2015","unstructured":"Le\u00e3o AH, Sarmento-Silva AJ, Santos JR et al (2015) Molecular, neurochemical, and behavioral hallmarks of reserpine as a model for Parkinson\u2019s disease: new perspectives to a long-standing model. Brain Pathol 25(4):377\u2013390","journal-title":"Brain Pathol"},{"issue":"1","key":"5429_CR42","volume":"2017","author":"G Lee","year":"2017","unstructured":"Lee G, Bae H (2017) Therapeutic effects of phytochemicals and medicinal herbs on depression. BioMed Res Int 2017(1):6596241","journal-title":"BioMed Res Int"},{"issue":"8","key":"5429_CR43","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.3390\/brainsci12081081","volume":"12","author":"L Lin","year":"2022","unstructured":"Lin L, Zhang J, Dai X et al (2022) A Moderate Duration of Stress Promotes Behavioral Adaptation and Spatial Memory in Young C57BL\/6J Mice. Brain Sci 12(8):1081","journal-title":"Brain Sci"},{"issue":"10","key":"5429_CR44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138904","volume":"10","author":"T Liu","year":"2015","unstructured":"Liu T, Zhong S, Liao X et al (2015) A meta-analysis of oxidative stress markers in depression. PLoS ONE 10(10):e0138904","journal-title":"PLoS ONE"},{"issue":"6","key":"5429_CR45","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1002\/glia.24343","volume":"71","author":"Y Liu","year":"2023","unstructured":"Liu Y, Shen X, Zhang Y et al (2023) Interactions of glial cells with neuronal synapses, from astrocytes to microglia and oligodendrocyte lineage cells. Glia 71(6):1383\u20131401","journal-title":"Glia"},{"issue":"1","key":"5429_CR46","doi-asserted-by":"publisher","first-page":"16","DOI":"10.4183\/aeb.2018.16","volume":"14","author":"AL L\u00f3pez","year":"2018","unstructured":"L\u00f3pez AL, Villanueva ME, Padilla MB et al (2018) Chronic unpredictable mild stress progressively disturbs glucose metabolism and appetite hormones in rats. Acta Endocrinologica (Bucharest) 14(1):16","journal-title":"Acta Endocrinologica (Bucharest)"},{"issue":"5","key":"5429_CR47","doi-asserted-by":"publisher","first-page":"531","DOI":"10.2174\/187152706778559273","volume":"5","author":"PJ Lucassen","year":"2006","unstructured":"Lucassen PJ, Heine VM, Muller MB et al (2006) Stress, depression and hippocampal apoptosis. CNS Neurol Disord Drug Targets 5(5):531\u2013546","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"3","key":"5429_CR48","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.pnpbp.2010.12.017","volume":"35","author":"M Maes","year":"2011","unstructured":"Maes M, Leonard BE, Myint AM et al (2011) The new \u201c5-HT\u201d hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression. Prog Neuropsychopharmacol Biol Psychiatry 35(3):702\u201321. https:\/\/doi.org\/10.1016\/j.pnpbp.2010.12.017","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"5429_CR49","doi-asserted-by":"crossref","unstructured":"M\u00e1rquez-Herrero S, Hern\u00e1ndez JI, Soler O, Guevara MA, Gargiulo P\u00c1 (2018) Animal models of depression: classification and relevant validation criteria. In: Psychiatry and neuroscience update: from translational research to a humanistic approach-volume III. Springer International Publishing, pp 221\u2013231","DOI":"10.1007\/978-3-319-95360-1_19"},{"key":"5429_CR50","first-page":"817","volume":"15","author":"MR McGill","year":"2016","unstructured":"McGill MR (2016) The past and present of serum aminotransferases and the future of liver injury biomarkers. EXCLI J 15:817","journal-title":"EXCLI J"},{"key":"5429_CR51","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fphys.2015.00006","volume":"6","author":"S Monteiro","year":"2015","unstructured":"Monteiro S, Roque S, de S\u00e1-Cal\u00e7ada D et al (2015) An efficient chronic unpredictable stress protocol to induce stress-related responses in C57BL\/6 mice. Front Psych 6:6","journal-title":"Front Psych"},{"issue":"4","key":"5429_CR52","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.neuint.2013.07.002","volume":"63","author":"VS Nade","year":"2013","unstructured":"Nade VS, Shendye NV, Kawale LA et al (2013) Protective effect of nebivolol on reserpine-induced neurobehavioral and biochemical alterations in rats. Neurochem Inter 63(4):316\u2013321","journal-title":"Neurochem Inter"},{"key":"5429_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1742-2094-9-147","volume":"9","author":"M Nikodemova","year":"2012","unstructured":"Nikodemova M, Watters JJ (2012) Efficient isolation of live microglia with preserved phenotypes from adult mouse brain. J Neuroinflamm 9:1\u201310","journal-title":"J Neuroinflamm"},{"key":"5429_CR54","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2024.110031","volume":"257","author":"EJ Nunes","year":"2024","unstructured":"Nunes EJ, Kebede N, Rajadhyaksha AM, Addy NA (2024) L-type calcium channel regulation of depression, anxiety and anhedonia-related behavioral phenotypes following chronic stress exposure. Neuropharmacol 257:110031","journal-title":"Neuropharmacol"},{"issue":"1","key":"5429_CR55","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1038\/s41598-023-28893-6","volume":"13","author":"OA Ojo","year":"2023","unstructured":"Ojo OA, Rotimi DE, Ojo AB et al (2023) Gallic acid abates cadmium chloride toxicity via alteration of neurotransmitters and modulation of inflammatory markers in Wistar rats. Sci Rep 13(1):1577","journal-title":"Sci Rep"},{"issue":"2","key":"5429_CR56","first-page":"97","volume":"2","author":"DS Olton","year":"1976","unstructured":"Olton DS, Samuelson RJ (1976) Remembrance of places passed: spatial memory in rats. J Exper Psychol: Animal Behavior Processes 2(2):97","journal-title":"J Exper Psychol: Animal Behavior Processes"},{"issue":"1 (28)","key":"5429_CR57","doi-asserted-by":"publisher","first-page":"58","DOI":"10.32607\/20758251-2016-8-1-58-73","volume":"8","author":"AM Petrov","year":"2016","unstructured":"Petrov AM, Kasimov MR, Zefirov AL (2016) Brain cholesterol metabolism and its defects: linkage to neurodegenerative diseases and synaptic dysfunction. Acta Naturae (a\u043d\u0433\u043bo\u044f\u0437\u044b\u0447\u043da\u044f \u0412epc\u0438\u044f) 8(1 (28)):58\u201373","journal-title":"Acta Naturae (a\u043d\u0433\u043bo\u044f\u0437\u044b\u0447\u043da\u044f \u0412epc\u0438\u044f)"},{"issue":"2","key":"5429_CR58","doi-asserted-by":"publisher","first-page":"95","DOI":"10.55579\/jaec.202372.400","volume":"7","author":"HTN Pham","year":"2023","unstructured":"Pham HTN, Phung HTT (2023) Comparing the performance of molecular docking tools for HIV-1 protease inhibitors. J Adv Engg Comp 7(2):95\u2013104","journal-title":"J Adv Engg Comp"},{"issue":"5604","key":"5429_CR59","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/266730a0","volume":"266","author":"RD Porsolt","year":"1977","unstructured":"Porsolt RD, Le Pichon M, Jalfre M (1977) Depression: a new animal model sensitive to antidepressant treatments. Nature 266(5604):730\u2013732","journal-title":"Nature"},{"key":"5429_CR60","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.euroneuro.2023.08.496","volume":"77","author":"MJ Primo","year":"2023","unstructured":"Primo MJ, Fonseca-Rodrigues D, Almeida A et al (2023) Sucrose preference test: a systematic review of protocols for the assessment of anhedonia in rodents. Eur Neuropsychopharmacol 77:80\u201392","journal-title":"Eur Neuropsychopharmacol"},{"issue":"4","key":"5429_CR61","first-page":"259","volume":"14","author":"X Qian","year":"2023","unstructured":"Qian X, Zhang Y, Tan HJ (2023) Chronic Fluoxetine treatment reverses depressive-like behaviors in mice via enhancing neuroplasticity. J Pharmacol Pharm 14(4):259\u2013267","journal-title":"J Pharmacol Pharm"},{"key":"5429_CR62","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2023.148723","volume":"1825","author":"X Qian","year":"2024","unstructured":"Qian X, Zhong ZD, Zhang Y et al (2024) Fluoxetine mitigates depressive-like behaviors in mice via anti-inflammation and enhancing neuroplasticity. Brain Res 1825:148723","journal-title":"Brain Res"},{"issue":"10","key":"5429_CR63","doi-asserted-by":"publisher","first-page":"9759","DOI":"10.1007\/s11033-022-07461-7","volume":"49","author":"S Rahmani","year":"2022","unstructured":"Rahmani S, Kadkhoda S, Ghafouri-Fard S (2022) Synaptic plasticity and depression: the role of miRNAs dysregulation. Mol Biol Rep 49(10):9759\u20139765","journal-title":"Mol Biol Rep"},{"issue":"21","key":"5429_CR64","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.1001\/jama.2016.17324","volume":"316","author":"LS Rotenstein","year":"2016","unstructured":"Rotenstein LS, Ramos MA, Torre M et al (2016) Prevalence of depression, depressive symptoms, and suicidal ideation among medical students: a systematic review and meta-analysis. JAMA 316(21):2214\u20132236","journal-title":"JAMA"},{"issue":"1","key":"5429_CR65","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1006\/nlme.1995.1038","volume":"64","author":"P Roullet","year":"1995","unstructured":"Roullet P (1995) Inter-session delay and its effects on performance and retention of spatial learning on a radial maze with mice. Neurobiol Learn Mem 64(1):4\u20139","journal-title":"Neurobiol Learn Mem"},{"issue":"1-3","key":"5429_CR66","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.jad.2010.05.012","volume":"127","author":"C Salustri","year":"2010","unstructured":"Salustri C, Squitti R, Zappasodi F et al (2010) Oxidative stress and brain glutamate-mediated excitability in depressed patients. J Affect Disord 127(1\u20133):321\u2013325","journal-title":"J Affect Disord"},{"key":"5429_CR67","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1007\/s11011-021-00789-2","volume":"36","author":"N Samad","year":"2021","unstructured":"Samad N, Manzoor N, Muneer Z et al (2021) Reserpine-induced altered neuro-behavioral, biochemical and histopathological assessments prevent by enhanced antioxidant defence system of Thymoquinone in mice. Metab Brain Dis 36:2535\u20132552","journal-title":"Metab Brain Dis"},{"issue":"8","key":"5429_CR68","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1038\/s12276-024-01273-4","volume":"56","author":"KC Shin","year":"2024","unstructured":"Shin KC, Ali Moussa HY, Park Y (2024) Cholesterol imbalance and neurotransmission defects in neurodegeneration. Exp Mol Med 56(8):1685\u20131690","journal-title":"Exp Mol Med"},{"key":"5429_CR69","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1001\/jama.2018.7028","volume":"319","author":"HS Soung","year":"2018","unstructured":"Soung HS, Wang MH, Chang KC et al (2018) Theanine decreases orofacial dyskinesia induced by Reserpine in rats. JAMA 319:2388\u20132400","journal-title":"JAMA"},{"issue":"3","key":"5429_CR70","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1177\/02698811221115762","volume":"37","author":"R Strawbridge","year":"2023","unstructured":"Strawbridge R, Javed RR, Cave J et al (2023) The effects of reserpine on depression: a systematic review. J Psychopharmacol 37(3):248\u2013260","journal-title":"J Psychopharmacol"},{"issue":"3","key":"5429_CR71","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s00213-021-05982-w","volume":"239","author":"T Strekalova","year":"2022","unstructured":"Strekalova T, Liu Y, Kiselev D et al (2022) Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives. Psychopharmacology 239(3):663\u2013693","journal-title":"Psychopharmacology"},{"key":"5429_CR72","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2024.111013","volume":"133","author":"LM Telega","year":"2024","unstructured":"Telega LM, Berti R, Blazhenets G et al (2024) Reserpine-induced rat model for depression: behavioral, physiological and PET-based dopamine receptor availability validation. Prog Neuropsychopharmacol Biol Psychiatry 133:111013","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"1","key":"5429_CR73","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.bbrc.2020.02.073","volume":"525","author":"S Tsuchimine","year":"2020","unstructured":"Tsuchimine S, Matsuno H, O\u2019Hashi K et al (2020) Comparison of physiological and behavioral responses to chronic restraint stress between C57BL\/6J and BALB\/c mice. Biochem Biophys Res Commun 525(1):33\u201338","journal-title":"Biochem Biophys Res Commun"},{"key":"5429_CR74","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1038\/s42003-023-05543-1","volume":"6","author":"V Valsecchi","year":"2023","unstructured":"Valsecchi V, Errico F, Bassareo V et al (2023) SMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy. Commun Biol 6:1155","journal-title":"Commun Biol"},{"key":"5429_CR75","doi-asserted-by":"crossref","unstructured":"Villegas J, Schulz M, Soto L, Sanchez R (2005) Bacteria induce expression of apoptosis in human spermatozoa. Apoptosis 10(1):105\u2013110","DOI":"10.1007\/s10495-005-6065-8"},{"key":"5429_CR76","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jad.2019.02.007","volume":"249","author":"R Wang","year":"2019","unstructured":"Wang R, Liu Y, Xue D et al (2019) Cross-sectional associations between long-term exposure to particulate matter and depression in China: the mediating effects of sunlight, physical activity, and neighborly reciprocity. J Affect Dis 249:8\u201314","journal-title":"J Affect Dis"},{"issue":"9","key":"5429_CR77","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.4014\/jmb.2405.05013","volume":"34","author":"Y Wang","year":"2024","unstructured":"Wang Y, Shi G, Zeng Y et al (2024) Antidepressant effect and mechanism of Picea mariana essential oil on reserpine-induced depression model mice. J Microbiol Biotechnol 34(9):1778","journal-title":"J Microbiol Biotechnol"},{"key":"5429_CR78","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1448750","volume":"16","author":"J Xu","year":"2025","unstructured":"Xu J, Wang B, Ao H (2025) Corticosterone effects induced by stress and immunity and inflammation: mechanisms of communication. Front Endocrinol 16:1448750","journal-title":"Front Endocrinol"},{"issue":"4","key":"5429_CR79","doi-asserted-by":"publisher","first-page":"494","DOI":"10.2174\/1570159X1304150831150507","volume":"13","author":"L Yang","year":"2015","unstructured":"Yang L, Zhao Y, Wang Y et al (2015) The effects of psychological stress on depression. Curr Neuropharmacol 13(4):494\u2013504","journal-title":"Curr Neuropharmacol"},{"issue":"2","key":"5429_CR80","first-page":"1343","volume":"19","author":"X Yao","year":"2020","unstructured":"Yao X, Li L, Kandhare AD et al (2020) Attenuation of reserpine-induced fibromyalgia via ROS and serotonergic pathway modulation by fisetin, a plant flavonoid polyphenol. Exp Ther Med 19(2):1343\u20131355","journal-title":"Exp Ther Med"},{"issue":"4","key":"5429_CR81","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1038\/mp.2017.255","volume":"23","author":"P Zanos","year":"2018","unstructured":"Zanos P, Gould T (2018) Mechanisms of ketamine action as an antidepressant. Mol Psychiatry 23(4):801\u2013811","journal-title":"Mol Psychiatry"},{"key":"5429_CR82","first-page":"38","volume":"10","author":"S Zaqout","year":"2016","unstructured":"Zaqout S, Kaindl AM (2016) Golgi-Cox staining step by step. Front Neur 10:38","journal-title":"Front Neur"},{"key":"5429_CR83","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2023.1197459","volume":"17","author":"P Zhang","year":"2023","unstructured":"Zhang P, Duan L, Ou Y et al (2023) The cerebellum and cognitive neural networks. Front Hum Neurosci 17:1197459","journal-title":"Front Hum Neurosci"},{"key":"5429_CR84","doi-asserted-by":"publisher","first-page":"351","DOI":"10.3389\/fphys.2020.00351","volume":"11","author":"Y Zhao","year":"2020","unstructured":"Zhao Y, Shang P, Wang M et al (2020) Neuroprotective effects of fluoxetine against chronic stress-induced neural inflammation and apoptosis: Involvement of the p38 activity. Front Physiol 11:351","journal-title":"Front Physiol"},{"issue":"8","key":"5429_CR85","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1111\/j.1872-034X.2012.00996.x","volume":"42","author":"R Zhu","year":"2012","unstructured":"Zhu R, Wang Y, Zhang L, Guo Q (2012) Oxidative stress and liver disease. Hepatol Res 42(8):741\u2013749","journal-title":"Hepatol Res"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05429-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05429-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05429-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:00:23Z","timestamp":1787670023000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05429-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,23]]},"references-count":85,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["5429"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05429-z","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,23]]},"assertion":[{"value":"9 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Approval to work with the mouse model was obtained from the Animal Ethical Committee (BHU\/DOZ\/IAEC\/2022\u201423\/018 dated 3\/10\/23) at the Institute of Science, Banaras Hindu University, Varanasi, India.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}