{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:38:00Z","timestamp":1792532280377,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["Grant No. 81603481"],"award-info":[{"award-number":["Grant No. 81603481"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["Grant No. 82174353"],"award-info":[{"award-number":["Grant No. 82174353"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s00210-026-05481-9","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T02:58:29Z","timestamp":1780973909000},"page":"18299-18314","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Identification of potential mechanisms of quercetin in diabetic peripheral neuropathy through integrated network pharmacology and experimental validation"],"prefix":"10.1007","volume":"399","author":[{"given":"Zanpeng","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunli","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"5481_CR1","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.jneumeth.2019.05.007","volume":"323","author":"SG Ahmed","year":"2019","unstructured":"Ahmed SG, Hadaegh F, Brenner GJ (2019) Developing myelin specific promoters for schwannoma gene therapy. J Neurosci Methods 323:77\u201381. https:\/\/doi.org\/10.1016\/j.jneumeth.2019.05.007","journal-title":"J Neurosci Methods"},{"key":"5481_CR2","doi-asserted-by":"publisher","first-page":"3839","DOI":"10.2147\/JIR.S465203","volume":"17","author":"A Al Mamun","year":"2024","unstructured":"Al Mamun A, Shao C, Geng P, Wang S, Xiao J (2024) Pyroptosis in diabetic peripheral neuropathy and its therapeutic regulation. J Inflamm Res 17:3839\u20133864. https:\/\/doi.org\/10.2147\/JIR.S465203","journal-title":"J Inflamm Res"},{"key":"5481_CR3","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700447","author":"S Andres","year":"2018","unstructured":"Andres S, Pevny S, Ziegenhagen R, Bakhiya N, Schafer B, Hirsch-Ernst KI, Lampen A (2018) Safety aspects of the use of quercetin as a dietary supplement. Mol Nutr Food Res. https:\/\/doi.org\/10.1002\/mnfr.201700447","journal-title":"Mol Nutr Food Res"},{"issue":"1","key":"5481_CR4","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s00289-022-04091-8","volume":"80","author":"M Azeem","year":"2023","unstructured":"Azeem M, Hanif M, Mahmood K, Ameer N, Chughtai FRS, Abid U (2023) An insight into anticancer, antioxidant, antimicrobial, antidiabetic and anti-inflammatory effects of quercetin: a review. Polym Bull (Berl) 80(1):241\u2013262. https:\/\/doi.org\/10.1007\/s00289-022-04091-8","journal-title":"Polym Bull (Berl)"},{"key":"5481_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910835","author":"P Baum","year":"2021","unstructured":"Baum P, Toyka KV, Bluher M, Kosacka J, Nowicki M (2021) Inflammatory mechanisms in the pathophysiology of diabetic peripheral neuropathy (DN)-new aspects. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms221910835","journal-title":"Int J Mol Sci"},{"issue":"2","key":"5481_CR6","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/jns5.12072","volume":"19","author":"GJ Biessels","year":"2014","unstructured":"Biessels GJ, Bril V, Calcutt NA, Cameron NE, Cotter MA, Dobrowsky R, Feldman EL, Fernyhough P, Jakobsen J, Malik RA, Mizisin AP, Oates PJ, Obrosova IG, Pop-Busui R, Russell JW, Sima AA, Stevens MJ, Schmidt RE, Tesfaye S, Veves A, Vinik AI, Wright DE, Yagihashi S, Yorek MA, Ziegler D, Zochodne DW (2014) Phenotyping animal models of diabetic neuropathy: a consensus statement of the Diabetic Neuropathy Study Group of the EASD (Neurodiab). J Peripher Nerv Syst 19(2):77\u201387. https:\/\/doi.org\/10.1111\/jns5.12072","journal-title":"J Peripher Nerv Syst"},{"issue":"1","key":"5481_CR7","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s11658-023-00462-9","volume":"28","author":"Y Chen","year":"2023","unstructured":"Chen Y, Ye X, Escames G, Lei W, Zhang X, Li M, Jing T, Yao Y, Qiu Z, Wang Z, Acuna-Castroviejo D, Yang Y (2023) The NLRP3 inflammasome: contributions to inflammation-related diseases. Cell Mol Biol Lett 28(1):51. https:\/\/doi.org\/10.1186\/s11658-023-00462-9","journal-title":"Cell Mol Biol Lett"},{"issue":"7","key":"5481_CR8","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1038\/s12276-023-01019-8","volume":"55","author":"EH Choi","year":"2023","unstructured":"Choi EH, Park SJ (2023) TXNIP: a key protein in the cellular stress response pathway and a potential therapeutic target. Exp Mol Med 55(7):1348\u20131356. https:\/\/doi.org\/10.1038\/s12276-023-01019-8","journal-title":"Exp Mol Med"},{"issue":"10","key":"5481_CR9","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/s41577-023-00849-x","volume":"23","author":"WC Chou","year":"2023","unstructured":"Chou WC, Jha S, Linhoff MW, Ting JP (2023) The NLR gene family: from discovery to present day. Nat Rev Immunol 23(10):635\u2013654. https:\/\/doi.org\/10.1038\/s41577-023-00849-x","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"5481_CR10","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1124\/pharmrev.120.000171","volume":"73","author":"SE Corcoran","year":"2021","unstructured":"Corcoran SE, Halai R, Cooper MA (2021) Pharmacological inhibition of the nod-like receptor family pyrin domain containing 3 inflammasome with MCC950. Pharmacol Rev 73(3):968\u20131000. https:\/\/doi.org\/10.1124\/pharmrev.120.000171","journal-title":"Pharmacol Rev"},{"issue":"10","key":"5481_CR11","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/S1474-4422(22)00188-0","volume":"21","author":"MA Elafros","year":"2022","unstructured":"Elafros MA, Andersen H, Bennett DL, Savelieff MG, Viswanathan V, Callaghan BC, Feldman EL (2022) Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments. Lancet Neurol 21(10):922\u2013936. https:\/\/doi.org\/10.1016\/S1474-4422(22)00188-0","journal-title":"Lancet Neurol"},{"issue":"1","key":"5481_CR12","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/s41572-019-0097-9","volume":"5","author":"EL Feldman","year":"2019","unstructured":"Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL, Bril V, Russell JW, Viswanathan V (2019) Diabetic neuropathy. Nat Rev Dis Primers 5(1):42. https:\/\/doi.org\/10.1038\/s41572-019-0097-9","journal-title":"Nat Rev Dis Primers"},{"issue":"Pt 1","key":"5481_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118792","volume":"337","author":"H Feng","year":"2025","unstructured":"Feng H, Wu T, Chin J, Ding R, Long C, Wang G, Yan D, Ma X, Yue R (2025) Tangzu granule alleviate neuroinflammation in diabetic peripheral neuropathy by suppressing pyroptosis through P2X7R \/NLRP3 signaling pathway. J Ethnopharmacol 337(Pt 1):118792. https:\/\/doi.org\/10.1016\/j.jep.2024.118792","journal-title":"J Ethnopharmacol"},{"issue":"12","key":"5481_CR14","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/0278-6915(95)00077-1","volume":"33","author":"JV Formica","year":"1995","unstructured":"Formica JV, Regelson W (1995) Review of the biology of quercetin and related bioflavonoids. Food Chem Toxicol 33(12):1061\u20131080. https:\/\/doi.org\/10.1016\/0278-6915(95)00077-1","journal-title":"Food Chem Toxicol"},{"key":"5481_CR15","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","volume":"41","author":"J Fu","year":"2023","unstructured":"Fu J, Wu H (2023) Structural mechanisms of NLRP3 inflammasome assembly and activation. Annu Rev Immunol 41:301\u2013316. https:\/\/doi.org\/10.1146\/annurev-immunol-081022-021207","journal-title":"Annu Rev Immunol"},{"issue":"11","key":"5481_CR16","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1016\/j.fct.2007.05.015","volume":"45","author":"M Harwood","year":"2007","unstructured":"Harwood M, Danielewska-Nikiel B, Borzelleca JF, Flamm GW, Williams GM, Lines TC (2007) A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic\/carcinogenic properties. Food Chem Toxicol 45(11):2179\u20132205. https:\/\/doi.org\/10.1016\/j.fct.2007.05.015","journal-title":"Food Chem Toxicol"},{"issue":"2","key":"5481_CR17","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1159\/000485089","volume":"44","author":"L He","year":"2017","unstructured":"He L, He T, Farrar S, Ji L, Liu T, Ma X (2017) Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species. Cell Physiol Biochem 44(2):532\u2013553. https:\/\/doi.org\/10.1159\/000485089","journal-title":"Cell Physiol Biochem"},{"issue":"3","key":"5481_CR18","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/mus.27086","volume":"63","author":"M Kazamel","year":"2021","unstructured":"Kazamel M, Stino AM, Smith AG (2021) Metabolic syndrome and peripheral neuropathy. Muscle Nerve 63(3):285\u2013293. https:\/\/doi.org\/10.1002\/mus.27086","journal-title":"Muscle Nerve"},{"issue":"12","key":"5481_CR19","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1007\/s00011-020-01402-5","volume":"69","author":"K Le","year":"2020","unstructured":"Le K, Song Z, Deng J, Peng X, Zhang J, Wang L, Zhou L, Bi H, Liao Z, Feng Z (2020) Quercetin alleviates neonatal hypoxic-ischemic brain injury by inhibiting microglia-derived oxidative stress and TLR4-mediated inflammation. Inflamm Res 69(12):1201\u20131213. https:\/\/doi.org\/10.1007\/s00011-020-01402-5","journal-title":"Inflamm Res"},{"issue":"21","key":"5481_CR20","doi-asserted-by":"publisher","first-page":"12156","DOI":"10.1021\/acs.jafc.4c01134","volume":"72","author":"H Li","year":"2024","unstructured":"Li H, Cao Z, Liu C, Wang Y, Wang L, Tang Y, Yao P (2024) Quercetin inhibits neuronal pyroptosis and ferroptosis by modulating microglial M1\/M2 polarization in atherosclerosis. J Agric Food Chem 72(21):12156\u201312170. https:\/\/doi.org\/10.1021\/acs.jafc.4c01134","journal-title":"J Agric Food Chem"},{"key":"5481_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2025.118164","volume":"189","author":"H Li","year":"2025","unstructured":"Li H, Liu T, Shi X, Du H, Cai C, Yang D, Qu L, Dou H, Jiao B, Jiao B (2025) Mechanisms and therapeutic potential of pharmacological agents targeting inflammasomes. Biomed Pharmacother 189:118164. https:\/\/doi.org\/10.1016\/j.biopha.2025.118164","journal-title":"Biomed Pharmacother"},{"issue":"8","key":"5481_CR22","doi-asserted-by":"publisher","first-page":"4574","DOI":"10.1007\/s12035-023-03342-7","volume":"60","author":"Q Lin","year":"2023","unstructured":"Lin Q, Li K, Chen Y, Xie J, Wu C, Cui C, Deng B (2023) Oxidative stress in diabetic peripheral neuropathy: pathway and mechanism-based treatment. Mol Neurobiol 60(8):4574\u20134594. https:\/\/doi.org\/10.1007\/s12035-023-03342-7","journal-title":"Mol Neurobiol"},{"key":"5481_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1128069","volume":"11","author":"X Liu","year":"2023","unstructured":"Liu X, Chen D, Fu H, Liu X, Zhang Q, Zhang J, Ding M, Wen J, Chang B (2023) Development and validation of a risk prediction model for early diabetic peripheral neuropathy based on a systematic review and meta-analysis. Front Public Health 11:1128069. https:\/\/doi.org\/10.3389\/fpubh.2023.1128069","journal-title":"Front Public Health"},{"issue":"8","key":"5481_CR24","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1182\/bloodadvances.2024015053","volume":"9","author":"PA Mehta","year":"2025","unstructured":"Mehta PA, Nelson A, Loveless S, Lane A, Fukuda T, Teusink-Cross A, Elder D, Lagory D, Miller E, Cancelas JA, Howell J, Zhao J, Mizuno K, Myers KC, Lake K, McIntosh K, Setchell KDR, Luebbering N, Edwards S, Chihanga T, Wells SI, Davies SM (2025) Phase 1 study of quercetin, a natural antioxidant for children and young adults with Fanconi anemia. Blood Adv 9(8):1927\u20131939. https:\/\/doi.org\/10.1182\/bloodadvances.2024015053","journal-title":"Blood Adv"},{"issue":"12","key":"5481_CR25","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.4239\/wjd.v12.i12.1979","volume":"12","author":"IN Mohamed","year":"2021","unstructured":"Mohamed IN, Li L, Ismael S, Ishrat T, El-Remessy AB (2021) Thioredoxin interacting protein, a key molecular switch between oxidative stress and sterile inflammation in cellular response. World J Diabetes 12(12):1979\u20131999. https:\/\/doi.org\/10.4239\/wjd.v12.i12.1979","journal-title":"World J Diabetes"},{"key":"5481_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052754","author":"N Qayyum","year":"2021","unstructured":"Qayyum N, Haseeb M, Kim MS, Choi S (2021) Role of thioredoxin-interacting protein in diseases and its therapeutic outlook. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms22052754","journal-title":"Int J Mol Sci"},{"issue":"12","key":"5481_CR27","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.4103\/1673-5374.135328","volume":"9","author":"L Qu","year":"2014","unstructured":"Qu L, Liang X, Gu B, Liu W (2014) Quercetin alleviates high glucose-induced Schwann cell damage by autophagy. Neural Regen Res 9(12):1195\u20131203. https:\/\/doi.org\/10.4103\/1673-5374.135328","journal-title":"Neural Regen Res"},{"issue":"8","key":"5481_CR28","doi-asserted-by":"publisher","first-page":"3180","DOI":"10.1021\/jf803579e","volume":"57","author":"MJ Ruiz","year":"2009","unstructured":"Ruiz MJ, Fernandez M, Pico Y, Manes J, Asensi M, Carda C, Asensio G, Estrela JM (2009) Dietary administration of high doses of Pterostilbene and Quercetin to mice is not toxic. J Agric Food Chem 57(8):3180\u20133186. https:\/\/doi.org\/10.1021\/jf803579e","journal-title":"J Agric Food Chem"},{"issue":"1","key":"5481_CR29","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/s41582-024-01041-y","volume":"21","author":"MG Savelieff","year":"2025","unstructured":"Savelieff MG, Elafros MA, Viswanathan V, Jensen TS, Bennett DL, Feldman EL (2025) The global and regional burden of diabetic peripheral neuropathy. Nat Rev Neurol 21(1):17\u201331. https:\/\/doi.org\/10.1038\/s41582-024-01041-y","journal-title":"Nat Rev Neurol"},{"issue":"12","key":"5481_CR30","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/S2213-8587(19)30081-6","volume":"7","author":"D Selvarajah","year":"2019","unstructured":"Selvarajah D, Kar D, Khunti K, Davies MJ, Scott AR, Walker J, Tesfaye S (2019) Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention. Lancet Diabetes Endocrinol 7(12):938\u2013948. https:\/\/doi.org\/10.1016\/S2213-8587(19)30081-6","journal-title":"Lancet Diabetes Endocrinol"},{"key":"5481_CR31","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/1742-2094-10-69","volume":"10","author":"X Shi","year":"2013","unstructured":"Shi X, Chen Y, Nadeem L, Xu G (2013) Beneficial effect of TNF-alpha inhibition on diabetic peripheral neuropathy. J Neuroinflammation 10:69. https:\/\/doi.org\/10.1186\/1742-2094-10-69","journal-title":"J Neuroinflammation"},{"issue":"5","key":"5481_CR32","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.conb.2007.08.003","volume":"17","author":"M Simons","year":"2007","unstructured":"Simons M, Trotter J (2007) Wrapping it up: the cell biology of myelination. Curr Opin Neurobiol 17(5):533\u2013540. https:\/\/doi.org\/10.1016\/j.conb.2007.08.003","journal-title":"Curr Opin Neurobiol"},{"key":"5481_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156033","volume":"135","author":"W Song","year":"2024","unstructured":"Song W, Zhao B, Wu Q, Gong Y, Jia Y, Zhang Y, Yang Y, Zhang B, Liang X, Zhang Q (2024) Gastrodin alleviates diabetic peripheral neuropathy by regulating energy homeostasis via activating AMPK and inhibiting MMP9. Phytomedicine 135:156033. https:\/\/doi.org\/10.1016\/j.phymed.2024.156033","journal-title":"Phytomedicine"},{"key":"5481_CR34","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.2147\/DMSO.S223842","volume":"12","author":"Q Sun","year":"2019","unstructured":"Sun Q, Wang C, Yan B, Shi X, Shi Y, Qu L, Liang X (2019) Jinmaitong ameliorates diabetic peripheral neuropathy through suppressing TXNIP\/NLRP3 inflammasome activation in the streptozotocin-induced diabetic rat model. Diabetes Metab Syndr Obes 12:2145\u20132155. https:\/\/doi.org\/10.2147\/DMSO.S223842","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"3","key":"5481_CR35","doi-asserted-by":"publisher","first-page":"247","DOI":"10.2174\/1573399816666200914141558","volume":"17","author":"R Tiwari","year":"2021","unstructured":"Tiwari R, Wal P, Singh P, Tiwari G, Rai A (2021) A review on mechanistic and pharmacological findings of diabetic peripheral neuropathy including pharmacotherapy. Curr Diabetes Rev 17(3):247\u2013258. https:\/\/doi.org\/10.2174\/1573399816666200914141558","journal-title":"Curr Diabetes Rev"},{"key":"5481_CR36","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c02015","author":"X Wang","year":"2021","unstructured":"Wang X, Cao Y, Chen S, Lin J, Bian J, Huang D (2021a) Anti-inflammation activity of flavones and their structure\u2013activity relationship. J Agric Food Chem. https:\/\/doi.org\/10.1021\/acs.jafc.1c02015","journal-title":"J Agric Food Chem"},{"issue":"12","key":"5481_CR37","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1111\/1440-1681.13573","volume":"48","author":"Y Wang","year":"2021","unstructured":"Wang Y, Xiong M, Wang M, Chen H, Li W, Zhou X (2021b) Quercetin promotes locomotor function recovery and axonal regeneration through induction of autophagy after spinal cord injury. Clin Exp Pharmacol Physiol 48(12):1642\u20131652. https:\/\/doi.org\/10.1111\/1440-1681.13573","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"5481_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110147","volume":"127","author":"J Xie","year":"2020","unstructured":"Xie J, Song W, Liang X, Zhang Q, Shi Y, Liu W, Shi X (2020) Protective effect of Quercetin on Streptozotocin-induced diabetic peripheral neuropathy rats through modulating gut microbiota and reactive oxygen species level. Biomed Pharmacother 127:110147. https:\/\/doi.org\/10.1016\/j.biopha.2020.110147","journal-title":"Biomed Pharmacother"},{"key":"5481_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.117138","volume":"240","author":"ZW Yu","year":"2020","unstructured":"Yu ZW, Zhang J, Li X, Wang Y, Fu YH, Gao XY (2020) A new research hot spot: the role of NLRP3 inflammasome activation, a key step in pyroptosis, in diabetes and diabetic complications. Life Sci 240:117138. https:\/\/doi.org\/10.1016\/j.lfs.2019.117138","journal-title":"Life Sci"},{"issue":"8","key":"5481_CR40","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.tins.2013.04.008","volume":"36","author":"J Zenker","year":"2013","unstructured":"Zenker J, Ziegler D, Chrast R (2013) Novel pathogenic pathways in diabetic neuropathy. Trends Neurosci 36(8):439\u2013449. https:\/\/doi.org\/10.1016\/j.tins.2013.04.008","journal-title":"Trends Neurosci"},{"key":"5481_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.636172","volume":"15","author":"Q Zhang","year":"2021","unstructured":"Zhang Q, Song W, Zhao B, Xie J, Sun Q, Shi X, Yan B, Tian G, Liang X (2021) Quercetin attenuates diabetic peripheral neuropathy by correcting mitochondrial abnormality via activation of AMPK\/PGC-1alpha pathway in vivo and in vitro. Front Neurosci 15:636172. https:\/\/doi.org\/10.3389\/fnins.2021.636172","journal-title":"Front Neurosci"},{"key":"5481_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174607","volume":"912","author":"B Zhao","year":"2021","unstructured":"Zhao B, Zhang Q, Liang X, Xie J, Sun Q (2021) Quercetin reduces inflammation in a rat model of diabetic peripheral neuropathy by regulating the TLR4\/MyD88\/NF-kappaB signalling pathway. Eur J Pharmacol 912:174607. https:\/\/doi.org\/10.1016\/j.ejphar.2021.174607","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"5481_CR43","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.jpha.2023.09.007","volume":"14","author":"B Zhao","year":"2024","unstructured":"Zhao B, Zhang Q, He Y, Cao W, Song W, Liang X (2024a) Targeted metabolomics reveals the aberrant energy status in diabetic peripheral neuropathy and the neuroprotective mechanism of traditional Chinese medicine JinMaiTong. J Pharm Anal 14(2):225\u2013243. https:\/\/doi.org\/10.1016\/j.jpha.2023.09.007","journal-title":"J Pharm Anal"},{"issue":"4","key":"5481_CR44","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.516","volume":"5","author":"L Zhao","year":"2024","unstructured":"Zhao L, Hu H, Zhang L, Liu Z, Huang Y, Liu Q, Jin L, Zhu M, Zhang L (2024b) Inflammation in diabetes complications: molecular mechanisms and therapeutic interventions. MedComm (2020) 5(4):e516. https:\/\/doi.org\/10.1002\/mco2.516","journal-title":"MedComm (2020)"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05481-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05481-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05481-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:24:37Z","timestamp":1787621077000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05481-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,9]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["5481"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05481-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-9065429\/v1","asserted-by":"object"}]},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,9]]},"assertion":[{"value":"8 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}