{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:29:00Z","timestamp":1790281740607,"version":"4.1.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["CSTB2024NSCQ-MSX0315"],"award-info":[{"award-number":["CSTB2024NSCQ-MSX0315"]}],"id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Third Affiliated Hospital of Chongqing Medical University Project","award":["KY23046"],"award-info":[{"award-number":["KY23046"]}]},{"name":"The Chongqing Key Specialty Construction Project in Clinical Pharmacy"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s00210-026-05489-1","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T03:36:49Z","timestamp":1779853009000},"page":"17735-17749","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Elucidating the molecular mechanisms linking bisphenol A to breast cancer: an integrated study of bioinformatics, machine learning, and molecular docking"],"prefix":"10.1007","volume":"399","author":[{"given":"Xinjue","family":"Bu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changlan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehua","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"issue":"9","key":"5489_CR1","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.4161\/cc.24289","volume":"12","author":"P Avena","year":"2013","unstructured":"Avena P, Anselmo W, Whitaker-Menezes D, Wang C, Pestell RG, Lamb RS et al (2013) Compartment-specific activation of PPARgamma governs breast cancer tumor growth, via metabolic reprogramming and symbiosis. Cell Cycle 12(9):1360\u20131370","journal-title":"Cell Cycle"},{"issue":"1","key":"5489_CR2","first-page":"127","volume":"19","author":"L Bao","year":"2020","unstructured":"Bao L, Guo T, Wang J, Zhang K, Bao M (2020) Prognostic genes of triple-negative breast cancer identified by weighted gene co-expression network analysis. Oncol Lett 19(1):127\u2013138","journal-title":"Oncol Lett"},{"key":"5489_CR3","doi-asserted-by":"crossref","unstructured":"Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M et al (2013) NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res 41(Database issue):D991\u20135","DOI":"10.1093\/nar\/gks1193"},{"issue":"70","key":"5489_CR4","doi-asserted-by":"publisher","first-page":"115620","DOI":"10.18632\/oncotarget.23360","volume":"8","author":"A Bilancio","year":"2017","unstructured":"Bilancio A, Bontempo P, Di Donato M, Conte M, Giovannelli P, Altucci L et al (2017) Bisphenol A induces cell cycle arrest in primary and prostate cancer cells through EGFR\/ERK\/p53 signaling pathway activation. Oncotarget 8(70):115620\u2013115631","journal-title":"Oncotarget"},{"issue":"1","key":"5489_CR5","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.kint.2020.07.035","volume":"99","author":"K Blazek","year":"2021","unstructured":"Blazek K, van Zwieten A, Saglimbene V, Teixeira-Pinto A (2021) A practical guide to multiple imputation of missing data in nephrology. Kidney Int 99(1):68\u201374","journal-title":"Kidney Int"},{"issue":"3","key":"5489_CR6","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I et al (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74(3):229\u2013263","journal-title":"CA Cancer J Clin"},{"key":"5489_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.129221","volume":"268","author":"P Deng","year":"2021","unstructured":"Deng P, Tan M, Zhou W, Chen C, Xi Y, Gao P et al (2021) Bisphenol A promotes breast cancer cell proliferation by driving miR-381-3p-PTTG1-dependent cell cycle progression. Chemosphere 268:129221","journal-title":"Chemosphere"},{"issue":"6","key":"5489_CR8","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3892\/ol.2020.12145","volume":"20","author":"MC Dumitrascu","year":"2020","unstructured":"Dumitrascu MC, Mares C, Petca RC, Sandru F, Popescu RI, Mehedintu C et al (2020) Carcinogenic effects of bisphenol A in breast and ovarian cancers. Oncol Lett 20(6):282","journal-title":"Oncol Lett"},{"issue":"7639","key":"5489_CR9","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/nature21056","volume":"542","author":"A Esteva","year":"2017","unstructured":"Esteva A, Kuprel B, Novoa RA, Ko J, Swetter SM, Blau HM et al (2017) Dermatologist-level classification of skin cancer with deep neural networks. Nature 542(7639):115\u2013118","journal-title":"Nature"},{"key":"5489_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1723066","volume":"13","author":"X Fang","year":"2026","unstructured":"Fang X, Wang S, Fu S (2026) Dissecting the MAPK signaling landscape in malignant melanoma: from BRAF and NRAS mutations to precision combination therapies. Front Cell Dev Biol 13:1723066","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"5489_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-025-03084-z","volume":"16","author":"Y Fu","year":"2025","unstructured":"Fu Y, Liu Y, Sui Z (2025) Integrated network toxicology and bioinformatics reveal PFAS-driven prognostic biomarkers and molecular mechanisms in breast cancer: insights from transcriptome analysis and molecular docking. Discov Oncol 16(1):1400","journal-title":"Discov Oncol"},{"key":"5489_CR12","doi-asserted-by":"publisher","first-page":"105328","DOI":"10.1016\/j.envint.2019.105328","volume":"134","author":"P Gao","year":"2020","unstructured":"Gao P, Wang L, Yang N, Wen J, Zhao M, Su G et al (2020) Peroxisome proliferator-activated receptor gamma (PPARgamma) activation and metabolism disturbance induced by bisphenol A and its replacement analog bisphenol S using in vitro macrophages and in vivo mouse models. Environ Int 134:105328","journal-title":"Environ Int"},{"issue":"7","key":"5489_CR13","doi-asserted-by":"publisher","first-page":"4539","DOI":"10.1097\/JS9.0000000000002455","volume":"111","author":"J Gao","year":"2025","unstructured":"Gao J, Zhang M, Chen Q, Ye K, Wu J, Wang T et al (2025) Integrating machine learning and molecular docking to decipher the molecular network of aflatoxin B1-induced hepatocellular carcinoma. Int J Surg 111(7):4539\u20134549","journal-title":"Int J Surg"},{"issue":"3","key":"5489_CR14","doi-asserted-by":"publisher","first-page":"230","DOI":"10.2174\/1874467212666190306164507","volume":"12","author":"SA Hafezi","year":"2019","unstructured":"Hafezi SA, Abdel-Rahman WM (2019) The endocrine disruptor bisphenol A (BPA) exerts a wide range of effects in carcinogenesis and response to therapy. Curr Mol Pharmacol 12(3):230\u2013238","journal-title":"Curr Mol Pharmacol"},{"issue":"2","key":"5489_CR15","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1002\/jcp.21417","volume":"216","author":"L Hegedus","year":"2008","unstructured":"Hegedus L, Cho H, Xie X, Eliceiri GL (2008) Additional MDA-MB-231 breast cancer cell matrix metalloproteinases promote invasiveness. J Cell Physiol 216(2):480\u2013485","journal-title":"J Cell Physiol"},{"key":"5489_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.144286","volume":"767","author":"N Jatkowska","year":"2021","unstructured":"Jatkowska N, Kud\u0142ak B, Lewandowska P, Liu W, Williams MJ, Schi\u00f6th HB (2021) Identification of synergistic and antagonistic actions of environmental pollutants: bisphenols A, S and F in the presence of DEP, DBP, BADGE and BADGE\u00b72HCl in three component mixtures. Sci Total Environ 767:144286","journal-title":"Sci Total Environ"},{"issue":"7","key":"5489_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2024.01.002","volume":"14","author":"Q Jia","year":"2024","unstructured":"Jia Q, Zhou Y, Song L, Shi X, Jiang X, Tao R et al (2024) Baicalin reduces chronic stress-induced breast cancer metastasis via directly targeting beta2-adrenergic receptor. J Pharm Anal 14(7):100934","journal-title":"J Pharm Anal"},{"issue":"2","key":"5489_CR18","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nbt1284","volume":"25","author":"MJ Keiser","year":"2007","unstructured":"Keiser MJ, Roth BL, Armbruster BN, Ernsberger P, Irwin JJ, Shoichet BK (2007) Relating protein pharmacology by ligand chemistry. Nat Biotechnol 25(2):197\u2013206","journal-title":"Nat Biotechnol"},{"issue":"4","key":"5489_CR19","doi-asserted-by":"publisher","first-page":"358","DOI":"10.7555\/JBR.31.20160162","volume":"31","author":"JY Kim","year":"2017","unstructured":"Kim JY, Choi HG, Lee HM, Lee GA, Hwang KA, Choi KC (2017) Effects of bisphenol compounds on the growth and epithelial mesenchymal transition of MCF-7 CV human breast cancer cells. J Biomed Res 31(4):358\u2013369","journal-title":"J Biomed Res"},{"issue":"2","key":"5489_CR20","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1093\/toxsci\/kfz119","volume":"170","author":"H Kim","year":"2019","unstructured":"Kim H, Kim HS, Piao YJ, Moon WK (2019) Bisphenol A promotes the invasive and metastatic potential of ductal carcinoma in situ and protumorigenic polarization of macrophages. Toxicol Sci 170(2):283\u2013295","journal-title":"Toxicol Sci"},{"issue":"D1","key":"5489_CR21","doi-asserted-by":"publisher","first-page":"D1516","DOI":"10.1093\/nar\/gkae1059","volume":"53","author":"S Kim","year":"2025","unstructured":"Kim S, Chen J, Cheng T, Gindulyte A, He J, He S et al (2025) PubChem 2025 update. Nucleic Acids Res 53(D1):D1516\u2013D1525","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"5489_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-54440-6","volume":"15","author":"H Lai","year":"2024","unstructured":"Lai H, Wang L, Qian R, Huang J, Zhou P, Ye G et al (2024) Interformer: an interaction-aware model for protein-ligand docking and affinity prediction. Nat Commun 15(1):10223","journal-title":"Nat Commun"},{"issue":"2","key":"5489_CR23","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1515\/HMBCI.2010.075","volume":"5","author":"CA Lamartiniere","year":"2011","unstructured":"Lamartiniere CA, Jenkins S, Betancourt AM, Wang J, Russo J (2011) Exposure to the endocrine disruptor bisphenol A alters susceptibility for mammary cancer. Horm Mol Biol Clin Investig 5(2):45\u201352","journal-title":"Horm Mol Biol Clin Investig"},{"key":"5489_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9:559","journal-title":"BMC Bioinformatics"},{"issue":"21","key":"5489_CR25","doi-asserted-by":"publisher","first-page":"10204","DOI":"10.1021\/acs.est.5c03906","volume":"59","author":"B Li","year":"2025","unstructured":"Li B, Xu C, Zhang D, Wang S, Xu J, Xiao B et al (2025) Combined analysis of network toxicology and multiomics revealed the potential mechanism of 6PPDQ-induced hepatotoxicity in mice. Environ Sci Technol 59(21):10204\u201310214","journal-title":"Environ Sci Technol"},{"key":"5489_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/toxics13020109","author":"F Long","year":"2025","unstructured":"Long F, Ren Y, Bi F, Wu Z, Zhang H, Li J et al (2025) Contamination characterization, toxicological properties, and health risk assessment of bisphenols in multiple media: current research status and future perspectives. Toxics. https:\/\/doi.org\/10.3390\/toxics13020109","journal-title":"Toxics"},{"issue":"1","key":"5489_CR27","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s42256-019-0138-9","volume":"2","author":"SM Lundberg","year":"2020","unstructured":"Lundberg SM, Erion G, Chen H, DeGrave A, Prutkin JM, Nair B et al (2020) From local explanations to global understanding with explainable AI for trees. Nat Mach Intell 2(1):56\u201367","journal-title":"Nat Mach Intell"},{"issue":"1","key":"5489_CR28","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1177\/0394632015572557","volume":"28","author":"FZ Lv","year":"2015","unstructured":"Lv FZ, Wang JL, Wu Y, Chen HF, Shen XY (2015) Knockdown of MMP12 inhibits the growth and invasion of lung adenocarcinoma cells. Int J Immunopathol Pharmacol 28(1):77\u201384","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"1","key":"5489_CR29","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1677\/JOE-07-0056","volume":"196","author":"R Moral","year":"2008","unstructured":"Moral R, Wang R, Russo IH, Lamartiniere CA, Pereira J, Russo J (2008) Effect of prenatal exposure to the endocrine disruptor bisphenol A on mammary gland morphology and gene expression signature. J Endocrinol 196(1):101\u2013112","journal-title":"J Endocrinol"},{"key":"5489_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2022.100470","volume":"21","author":"J Niemeyer Hultstrand","year":"2022","unstructured":"Niemeyer Hultstrand J, Gemzell-Danielsson K, Kallner HK, Lindman H, Wikman P, Sundstr\u00f6m-Poromaa I (2022) Hormonal contraception and risk of breast cancer and breast cancer in situ among Swedish women 15-34 years of age: a nationwide register-based study. Lancet Reg Health Eur 21:100470","journal-title":"Lancet Reg Health Eur"},{"issue":"6","key":"5489_CR31","first-page":"6618","volume":"14","author":"YY Pei","year":"2017","unstructured":"Pei YY, Li GC, Ran J, Wei FX (2017) Kinesin family member 11 contributes to the progression and prognosis of human breast cancer. Oncol Lett 14(6):6618\u20136626","journal-title":"Oncol Lett"},{"key":"5489_CR32","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.chemosphere.2019.04.174","volume":"229","author":"K Pogrmic-Majkic","year":"2019","unstructured":"Pogrmic-Majkic K, Samardzija Nenadov D, Fa S, Stanic B, Trninic Pjevic A, Andric N (2019) BPA activates EGFR and ERK1\/2 through PPARgamma to increase expression of steroidogenic acute regulatory protein in human cumulus granulosa cells. Chemosphere 229:60\u201367","journal-title":"Chemosphere"},{"issue":"5","key":"5489_CR33","doi-asserted-by":"publisher","first-page":"296","DOI":"10.4161\/cbt.18942","volume":"13","author":"XY Qin","year":"2012","unstructured":"Qin XY, Fukuda T, Yang L, Zaha H, Akanuma H, Zeng Q et al (2012) Effects of bisphenol A exposure on the proliferation and senescence of normal human mammary epithelial cells. Cancer Biol Ther 13(5):296\u2013306","journal-title":"Cancer Biol Ther"},{"issue":"7","key":"5489_CR34","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W et al (2015) limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 43(7):e47","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"5489_CR35","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-022-01526-y","volume":"24","author":"B Rousseau","year":"2022","unstructured":"Rousseau B, Murugan S, Palagani A, Sarkar DK (2022) Beta 2 adrenergic receptor and mu opioid receptor interact to potentiate the aggressiveness of human breast cancer cell by activating the glycogen synthase kinase 3 signaling. Breast Cancer Res 24(1):33","journal-title":"Breast Cancer Res"},{"issue":"3","key":"5489_CR36","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1093\/carcin\/bgx003","volume":"38","author":"SJ Sauer","year":"2017","unstructured":"Sauer SJ, Tarpley M, Shah I, Save AV, Lyerly HK, Patierno SR et al (2017) Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells. Carcinogenesis 38(3):252\u2013260","journal-title":"Carcinogenesis"},{"key":"5489_CR37","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13061319","author":"AE Schmitz","year":"2025","unstructured":"Schmitz AE, Udgata S, Johnson KA, Deming DA (2025) The precision-guided use of PI3K pathway inhibitors for the treatment of solid malignancies. Biomedicines. https:\/\/doi.org\/10.3390\/biomedicines13061319","journal-title":"Biomedicines"},{"issue":"5","key":"5489_CR38","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.21037\/jgo-24-516","volume":"15","author":"D Si","year":"2024","unstructured":"Si D, Shu Y, Jiang H, Lin X, Yuan Q, Deng S et al (2024) Construction of diagnostic models with machine-learning algorithms for colorectal cancer based on clinical laboratory parameters. J Gastrointest Oncol 15(5):2145\u20132156","journal-title":"J Gastrointest Oncol"},{"key":"5489_CR39","doi-asserted-by":"publisher","first-page":"1280099","DOI":"10.3389\/fphar.2023.1280099","volume":"14","author":"Y Su","year":"2023","unstructured":"Su Y, Wang Y, Qu Z, Liu J, Ren X, Zhang D et al (2023) Multi-level characteristics recognition of cancer core therapeutic targets and drug screening for a broader patient population. Front Pharmacol 14:1280099","journal-title":"Front Pharmacol"},{"issue":"4","key":"5489_CR40","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.cvdhj.2023.06.001","volume":"4","author":"C Tarabanis","year":"2023","unstructured":"Tarabanis C, Kalampokis E, Khalil M, Alviar CL, Chinitz LA, Jankelson L (2023) Explainable SHAP-XGBoost models for in-hospital mortality after myocardial infarction. Cardiovasc Digit Health J 4(4):126\u2013132","journal-title":"Cardiovasc Digit Health J"},{"key":"5489_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2023.111998","volume":"575","author":"P Torres-Alamilla","year":"2023","unstructured":"Torres-Alamilla P, Castillo-Sanchez R, Cortes-Reynosa P, Gomez R, Perez Salazar E (2023) Bisphenol A increases the size of primary mammary tumors and promotes metastasis in a murine model of breast cancer. Mol Cell Endocrinol 575:111998","journal-title":"Mol Cell Endocrinol"},{"key":"5489_CR42","doi-asserted-by":"crossref","unstructured":"Useini A, Schwerin IK, K\u00fcnze G, Str\u00e4ter N (2024) Structural Studies on the Binding Mode of Bisphenols to PPAR\u03b3. Biomolecules 14(6):640","DOI":"10.3390\/biom14060640"},{"issue":"3","key":"5489_CR43","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1021\/acs.chemrestox.2c00002","volume":"35","author":"R Uyar","year":"2022","unstructured":"Uyar R, Yurdakok-Dikmen B, Turgut Y, Filazi A (2022) Diethylhexyl phthalate and bisphenol A promote vincristine and tamoxifen resistance in vitro. Chem Res Toxicol 35(3):538\u2013546","journal-title":"Chem Res Toxicol"},{"issue":"2","key":"5489_CR44","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.reprotox.2007.07.010","volume":"24","author":"LN Vandenberg","year":"2007","unstructured":"Vandenberg LN, Hauser R, Marcus M, Olea N, Welshons WV (2007) Human exposure to bisphenol A (BPA). Reprod Toxicol 24(2):139\u2013177","journal-title":"Reprod Toxicol"},{"issue":"W1","key":"5489_CR45","doi-asserted-by":"publisher","first-page":"W356","DOI":"10.1093\/nar\/gkx374","volume":"45","author":"X Wang","year":"2017","unstructured":"Wang X, Shen Y, Wang S, Li S, Zhang W, Liu X et al (2017) PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database. Nucleic Acids Res 45(W1):W356\u2013W360","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"5489_CR46","doi-asserted-by":"publisher","first-page":"192","DOI":"10.14715\/cmb\/2022.68.5.26","volume":"68","author":"R Wen","year":"2022","unstructured":"Wen R, Lin H, Li X, Lai X, Yang F (2022) The regulatory mechanism of EpCAM N-glycosylation-mediated MAPK and PI3K\/Akt pathways on epithelial-mesenchymal transition in breast cancer cells. Cell Mol Biol (Noisy-Le-Grand) 68(5):192\u2013201","journal-title":"Cell Mol Biol (Noisy-Le-Grand)"},{"issue":"11","key":"5489_CR47","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1093\/bioinformatics\/btg146","volume":"19","author":"DL Wilson","year":"2003","unstructured":"Wilson DL, Buckley MJ, Helliwell CA, Wilson IW (2003) New normalization methods for cDNA microarray data. Bioinformatics 19(11):1325\u20131332","journal-title":"Bioinformatics"},{"issue":"22","key":"5489_CR48","first-page":"9965","volume":"23","author":"YY Xu","year":"2019","unstructured":"Xu YY, Liu H, Su L, Xu N, Xu DH, Liu HY et al (2019) PPARgamma inhibits breast cancer progression by upregulating PTPRF expression. Eur Rev Med Pharmacol Sci 23(22):9965\u20139977","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"5489_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.118480","volume":"300","author":"B Yuan","year":"2025","unstructured":"Yuan B, Li Y, Chang J, Guo C, Huang W, Wang Y (2025) Molecular mechanism of bisphenols induction of breast cancer through PGR revealed by network toxicology and transcriptomics integration analysis. Ecotoxicol Environ Saf 300:118480","journal-title":"Ecotoxicol Environ Saf"},{"issue":"D1","key":"5489_CR50","doi-asserted-by":"publisher","first-page":"D1180","DOI":"10.1093\/nar\/gkad1004","volume":"52","author":"B Zdrazil","year":"2024","unstructured":"Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S et al (2024) The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res 52(D1):D1180\u2013D1192","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"5489_CR51","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3892\/mmr.2016.5286","volume":"5","author":"W Zhang","year":"2012","unstructured":"Zhang W, Fang Y, Shi X, Zhang M, Wang X, Tan Y (2012) Effect of bisphenol A on the EGFR-STAT3 pathway in MCF-7 breast cancer cells. Mol Med Rep 5(1):41\u201347","journal-title":"Mol Med Rep"},{"key":"5489_CR52","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.abb.2015.09.006","volume":"585","author":"X-L Zhang","year":"2015","unstructured":"Zhang X-L, Wang H-S, Liu N, Ge L-C (2015) Bisphenol A stimulates the epithelial mesenchymal transition of estrogen negative breast cancer cells via FOXA1 signals. Arch Biochem Biophys 585:10\u201316","journal-title":"Arch Biochem Biophys"},{"issue":"4","key":"5489_CR53","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/bcpt.12591","volume":"119","author":"XL Zhang","year":"2016","unstructured":"Zhang XL, Liu N, Weng SF, Wang HS (2016) Bisphenol A increases the migration and invasion of triple-negative breast cancer cells via oestrogen-related receptor gamma. Basic Clin Pharmacol Toxicol 119(4):389\u2013395","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"5489_CR54","doi-asserted-by":"publisher","first-page":"112453","DOI":"10.1016\/j.ecoenv.2021.112453","volume":"221","author":"X Zhang","year":"2021","unstructured":"Zhang X, Cheng C, Zhang G, Xiao M, Li L, Wu S et al (2021) Co-exposure to BPA and DEHP enhances susceptibility of mammary tumors via up-regulating Esr1\/HDAC6 pathway in female rats. Ecotoxicol Environ Saf 221:112453","journal-title":"Ecotoxicol Environ Saf"},{"issue":"8","key":"5489_CR55","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1002\/oby.24327","volume":"33","author":"Y Zhu","year":"2025","unstructured":"Zhu Y, Liu K, Guo J, Wang Y, Yang J, Su Y (2025) Associations between coexposure to bisphenols mixture and metabolic diseases: based on three statistical models. Obesity (Silver Spring) 33(8):1580\u20131594","journal-title":"Obesity (Silver Spring)"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05489-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05489-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05489-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:01:57Z","timestamp":1787623317000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05489-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,27]]},"references-count":55,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["5489"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05489-1","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,27]]},"assertion":[{"value":"5 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}