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Forty-seven individuals with periodontitis underwent a standard periodontal treatment (scaling and root planing), followed by adjuvant therapy according to the\u2009=\u2009groups: Vehicle Group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200915), receiving local application of the FeTcPc gel vehicle; Chlorhexidine (CLX) Group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200916), receiving local application of 0.12% chlorhexidine gel; and FeTcPc Group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200916), receiving local application of 1% FeTcPc-containing gel. Clinical evaluations were performed at baseline and after 45\u00a0days. No statistically significant differences were observed between the study groups in any periodontal clinical parameters at baseline or 45\u00a0days after treatment. In the intragroup analysis, the mean probing depth (PD) and the percentage of sites with PD\u2009\u2264\u20093\u00a0mm and PD\u2009=\u20094\u20135\u00a0mm showed a statistically significant reduction at 45\u00a0days in both the vehicle and FeTcPc groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The percentage of sites with bleeding on probing and the plaque index demonstrated a statistically significant reduction after 45\u00a0days in all groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The use of FeTcPc mouth gel as an adjunct to non-surgical periodontal therapy did not improve the clinical periodontal parameters compared to CLX or the vehicle group in this study.\n                  <\/jats:p>","DOI":"10.1007\/s00210-026-05517-0","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T05:27:05Z","timestamp":1780723625000},"page":"18085-18094","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phthalocyanine-based mouth gel as an adjunct to non-surgical periodontal treatment: a randomized controlled trial"],"prefix":"10.1007","volume":"399","author":[{"given":"Sebasti\u00e3o Orestes Pereira","family":"Neto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Luiz","family":"Rosalen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Vitor","family":"da Cruz Pegoraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isadora Stella Souza e","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luiza Marques","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Silva","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Tiburcio","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Jos\u00e9 Pimentel Lopes","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiano Vieira","family":"Vilhena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Ikegaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzane Cristina","family":"Pigossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro Ara\u00fajo","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Franchin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"key":"5517_CR1","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1902\/jop.1988.59.8.493","volume":"59","author":"PA Adriaens","year":"1988","unstructured":"Adriaens PA, Edwards CA, De Boever JA, Loesche WJ (1988) Ultrastructural observations on bacterial invasion in cementum and radicular dentin of periodontally diseased human teeth. 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