{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:05:01Z","timestamp":1791612301848,"version":"4.3.4"},"reference-count":112,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s00210-026-05543-y","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T03:50:44Z","timestamp":1780977044000},"page":"16885-16902","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nitric oxide in neuroinflammation and neurodegeneration: dual roles, inflammasome crosstalk, and biomarker opportunities"],"prefix":"10.1007","volume":"399","author":[{"given":"Gayatri","family":"Korade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashikanth","family":"Kharat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karishma","family":"Rathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"5543_CR1","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1080\/01616412.1997.11740784","volume":"19","author":"K Abe","year":"1997","unstructured":"Abe K, Pan L-H, Watanabe M et al (1997) Upregulation of protein-tyrosine nitration in the anterior horn cells of amyotrophic lateral sclerosis. Neurol Res 19:124\u2013128. https:\/\/doi.org\/10.1080\/01616412.1997.11740784","journal-title":"Neurol Res"},{"key":"5543_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2463","volume":"10","author":"SB Abramson","year":"2008","unstructured":"Abramson SB (2008) Nitric oxide in inflammation and pain associated with osteoarthritis. Arthritis Res Ther 10:S2. https:\/\/doi.org\/10.1186\/ar2463","journal-title":"Arthritis Res Ther"},{"key":"5543_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1347987","author":"A Adamu","year":"2024","unstructured":"Adamu A, Li S, Gao F, Xue G (2024) The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets. Front Aging Neurosci. https:\/\/doi.org\/10.3389\/fnagi.2024.1347987","journal-title":"Front Aging Neurosci"},{"key":"5543_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00271","author":"C Angeloni","year":"2019","unstructured":"Angeloni C, Barbalace MC, Hrelia S (2019) Icariin and its metabolites as potential protective phytochemicals against Alzheimer\u2019s disease. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2019.00271","journal-title":"Front Pharmacol"},{"key":"5543_CR5","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.neuint.2014.04.014","volume":"72","author":"S Aras","year":"2014","unstructured":"Aras S, Tanriover G, Aslan M et al (2014) The role of nitric oxide on visual-evoked potentials in MPTP-induced Parkinsonism in mice. Neurochem Int 72:48\u201357. https:\/\/doi.org\/10.1016\/j.neuint.2014.04.014","journal-title":"Neurochem Int"},{"key":"5543_CR6","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.niox.2023.03.003","volume":"134\u2013135","author":"A Azargoonjahromi","year":"2023","unstructured":"Azargoonjahromi A (2023) Dual role of nitric oxide in Alzheimer\u2019s disease. Nitric Oxide 134\u2013135:23\u201337. https:\/\/doi.org\/10.1016\/j.niox.2023.03.003","journal-title":"Nitric Oxide"},{"key":"5543_CR7","doi-asserted-by":"publisher","first-page":"12041","DOI":"10.1073\/pnas.92.26.12041","volume":"92","author":"O Bagasra","year":"1995","unstructured":"Bagasra O, Michaels FH, Zheng YM et al (1995) Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis. Proc Natl Acad Sci USA 92:12041\u201312045. https:\/\/doi.org\/10.1073\/pnas.92.26.12041","journal-title":"Proc Natl Acad Sci USA"},{"key":"5543_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02985-x","volume":"11","author":"B Bai","year":"2020","unstructured":"Bai B, Yang Y, Wang Q et al (2020) NLRP3 inflammasome in endothelial dysfunction. Cell Death Dis 11:776. https:\/\/doi.org\/10.1038\/s41419-020-02985-x","journal-title":"Cell Death Dis"},{"key":"5543_CR9","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3806157","volume":"2016","author":"R Balez","year":"2016","unstructured":"Balez R, Ooi L (2016) Getting to NO Alzheimer\u2019s disease: neuroprotection versus neurotoxicity mediated by nitric oxide. Oxid Med Cell Longev 2016:3806157. https:\/\/doi.org\/10.1155\/2016\/3806157","journal-title":"Oxid Med Cell Longev"},{"key":"5543_CR10","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0047-6374(83)90064-7","volume":"23","author":"D Bhaskaran","year":"1983","unstructured":"Bhaskaran D, Radha E (1983) Monoamine levels and monoamine oxidase activity in different regions of rat brain as a function of age. Mech Ageing Dev 23:151\u2013160. https:\/\/doi.org\/10.1016\/0047-6374(83)90064-7","journal-title":"Mech Ageing Dev"},{"key":"5543_CR11","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1002\/ana.410360515","volume":"36","author":"L B\u00f6","year":"1994","unstructured":"B\u00f6 L, Dawson TM, Wesselingh S et al (1994) Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. Ann Neurol 36:778\u2013786. https:\/\/doi.org\/10.1002\/ana.410360515","journal-title":"Ann Neurol"},{"key":"5543_CR12","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1124\/mol.58.5.1026","volume":"58","author":"R Boer","year":"2000","unstructured":"Boer R, Ulrich WR, Klein T et al (2000) The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes. Mol Pharmacol 58:1026\u20131034","journal-title":"Mol Pharmacol"},{"key":"5543_CR13","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/s0952-7915(99)00052-7","volume":"12","author":"C Bogdan","year":"2000","unstructured":"Bogdan C, R\u00f6llinghoff M, Diefenbach A (2000) Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity. Curr Opin Immunol 12:64\u201376. https:\/\/doi.org\/10.1016\/s0952-7915(99)00052-7","journal-title":"Curr Opin Immunol"},{"key":"5543_CR14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2009579118","volume":"118","author":"J-M Bourgognon","year":"2021","unstructured":"Bourgognon J-M, Spiers JG, Robinson SW et al (2021) Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease. Proc Natl Acad Sci U S A 118:e2009579118. https:\/\/doi.org\/10.1073\/pnas.2009579118","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5543_CR15","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.4049\/jimmunol.0802954","volume":"182","author":"R Brambilla","year":"2009","unstructured":"Brambilla R, Persaud T, Hu X et al (2009) Transgenic inhibition of astroglial NF-\u03baB improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation. J Immunol 182:2628\u20132640. https:\/\/doi.org\/10.4049\/jimmunol.0802954","journal-title":"J Immunol"},{"key":"5543_CR16","doi-asserted-by":"publisher","first-page":"7606","DOI":"10.1073\/pnas.94.14.7606","volume":"94","author":"LI Bruijn","year":"1997","unstructured":"Bruijn LI, Beal MF, Becher MW et al (1997) Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant. Proc Natl Acad Sci U S A 94:7606\u20137611. https:\/\/doi.org\/10.1073\/pnas.94.14.7606","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5543_CR17","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1089\/ars.2006.8.444","volume":"8","author":"V Calabrese","year":"2006","unstructured":"Calabrese V, Butterfield DA, Scapagnini G et al (2006) Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: relevance to brain aging, neurodegenerative disorders, and longevity. Antioxid Redox Signal 8:444\u2013477. https:\/\/doi.org\/10.1089\/ars.2006.8.444","journal-title":"Antioxid Redox Signal"},{"key":"5543_CR18","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/nrn2214","volume":"8","author":"V Calabrese","year":"2007","unstructured":"Calabrese V, Mancuso C, Calvani M et al (2007) Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity. Nat Rev Neurosci 8:766\u2013775. https:\/\/doi.org\/10.1038\/nrn2214","journal-title":"Nat Rev Neurosci"},{"key":"5543_CR19","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1097\/WCO.0000000000001279","volume":"37","author":"AD Calma","year":"2024","unstructured":"Calma AD, Pavey N, Menon P, Vucic S (2024) Neuroinflammation in amyotrophic lateral sclerosis: pathogenic insights and therapeutic implications. Curr Opin Neurol 37:585\u2013592. https:\/\/doi.org\/10.1097\/WCO.0000000000001279","journal-title":"Curr Opin Neurol"},{"key":"5543_CR20","doi-asserted-by":"publisher","first-page":"16295","DOI":"10.1074\/jbc.M413111200","volume":"280","author":"F Casoni","year":"2005","unstructured":"Casoni F, Basso M, Massignan T et al (2005) Protein nitration in a mouse model of familial amyotrophic lateral sclerosis. J Biol Chem 280:16295\u201316304. https:\/\/doi.org\/10.1074\/jbc.M413111200","journal-title":"J Biol Chem"},{"key":"5543_CR21","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/jnr.10107","volume":"67","author":"P Cassina","year":"2002","unstructured":"Cassina P, Peluffo H, Pehar M et al (2002) Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis. J Neurosci Res 67:21\u201329. https:\/\/doi.org\/10.1002\/jnr.10107","journal-title":"J Neurosci Res"},{"key":"5543_CR22","doi-asserted-by":"publisher","first-page":"35265","DOI":"10.1074\/jbc.M805287200","volume":"283","author":"Y-Y Chen","year":"2008","unstructured":"Chen Y-Y, Chu H-M, Pan K-T et al (2008) Cysteine S-nitrosylation protects protein-tyrosine phosphatase 1B against oxidation-induced permanent inactivation. J Biol Chem 283:35265\u201335272. https:\/\/doi.org\/10.1074\/jbc.M805287200","journal-title":"J Biol Chem"},{"key":"5543_CR23","doi-asserted-by":"publisher","first-page":"4309","DOI":"10.1021\/jm300106z","volume":"55","author":"Y Chen","year":"2012","unstructured":"Chen Y, Sun J, Fang L et al (2012) Tacrine\u2013Ferulic Acid\u2013Nitric Oxide (NO) Donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors. J Med Chem 55:4309\u20134321. https:\/\/doi.org\/10.1021\/jm300106z","journal-title":"J Med Chem"},{"key":"5543_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/alz.051847","volume":"17","author":"F Cheng","year":"2021","unstructured":"Cheng F, Fang J, Zhang P et al (2021) Sildenafil reduces the incidence of Alzheimer\u2019s disease. Alzheimers Dement 17:e051847. https:\/\/doi.org\/10.1002\/alz.051847","journal-title":"Alzheimers Dement"},{"key":"5543_CR25","doi-asserted-by":"publisher","first-page":"S14","DOI":"10.1016\/j.freeradbiomed.2014.10.586","volume":"75","author":"M-V Clement","year":"2014","unstructured":"Clement M-V (2014) Nitric oxide-based protein modification: formation and site-specificity of protein S-nitrosylation: could protein S-nitrosylation be the unifying oxidative modification to explain the cellular signaling activity of superoxide and hydrogen peroxide? Free Radic Biol Med 75:S14. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2014.10.586","journal-title":"Free Radic Biol Med"},{"key":"5543_CR26","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1084\/jem.20110698","volume":"209","author":"E Colombo","year":"2012","unstructured":"Colombo E, Cordiglieri C, Melli G et al (2012) Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration. Journal of Experimental Medicine 209:521\u2013535. https:\/\/doi.org\/10.1084\/jem.20110698","journal-title":"Journal of Experimental Medicine"},{"key":"5543_CR27","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1080\/146608202760196048","volume":"3","author":"MR Cookson","year":"2002","unstructured":"Cookson MR, Menzies FM, Manning P et al (2002) Cu\/Zn superoxide dismutase (SOD1) mutations associated with familial amyotrophic lateral sclerosis (ALS) affect cellular free radical release in the presence of oxidative stress. Amyotrophic Lateral Sclerosis 3:75\u201385. https:\/\/doi.org\/10.1080\/146608202760196048","journal-title":"Amyotrophic Lateral Sclerosis"},{"key":"5543_CR28","doi-asserted-by":"publisher","first-page":"2792","DOI":"10.1634\/stemcells.2005-0640","volume":"24","author":"R Covacu","year":"2006","unstructured":"Covacu R, Danilov AI, Rasmussen BS et al (2006) Nitric oxide exposure diverts neural stem cell fate from neurogenesis towards astrogliogenesis. STEM CELLS 24:2792\u20132800. https:\/\/doi.org\/10.1634\/stemcells.2005-0640","journal-title":"STEM CELLS"},{"key":"5543_CR29","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1164\/ajrccm.162.5.9912125","volume":"162","author":"S Cuzzocrea","year":"2000","unstructured":"Cuzzocrea S, Mazzon E, Calabro G et al (2000) Inducible nitric oxide synthase\u2014knockout mice exhibit resistance to pleurisy and lung injury caused by carrageenan. American Journal of Respiratory and Critical Care Medicine 162:1859\u20131866. https:\/\/doi.org\/10.1164\/ajrccm.162.5.9912125","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"5543_CR30","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1038\/nprot.2007.210","volume":"2","author":"B Derakhshan","year":"2007","unstructured":"Derakhshan B, Wille PC, Gross SS (2007) Unbiased identification of cysteine S-nitrosylation sites on proteins. Nat Protoc 2:1685\u20131691. https:\/\/doi.org\/10.1038\/nprot.2007.210","journal-title":"Nat Protoc"},{"key":"5543_CR31","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/mi.2008.27","volume":"1","author":"JV Forrester","year":"2008","unstructured":"Forrester JV, Xu H, Lambe T, Cornall R (2008) Immune privilege or privileged immunity? Mucosal Immunol 1:372\u2013381. https:\/\/doi.org\/10.1038\/mi.2008.27","journal-title":"Mucosal Immunol"},{"key":"5543_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26073412","volume":"26","author":"M F\u00f6rster","year":"2025","unstructured":"F\u00f6rster M, R\u00e4uber S, Albrecht P et al (2025) Do nitrosative stress molecules hold promise as biomarkers for multiple sclerosis? IJMS 26:3412. https:\/\/doi.org\/10.3390\/ijms26073412","journal-title":"IJMS"},{"key":"5543_CR33","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","volume":"33","author":"U Forstermann","year":"2012","unstructured":"Forstermann U, Sessa WC (2012) Nitric oxide synthases: regulation and function. Eur Heart J 33:829\u2013837. https:\/\/doi.org\/10.1093\/eurheartj\/ehr304","journal-title":"Eur Heart J"},{"key":"5543_CR34","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.immuni.2011.02.006","volume":"34","author":"G Guarda","year":"2011","unstructured":"Guarda G, Braun M, Staehli F et al (2011) Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 34:213\u2013223. https:\/\/doi.org\/10.1016\/j.immuni.2011.02.006","journal-title":"Immunity"},{"key":"5543_CR35","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1586\/14779072.4.3.293","volume":"4","author":"AR Hemnes","year":"2006","unstructured":"Hemnes AR, Champion HC (2006) Sildenafil, a PDE5 inhibitor, in the treatment of pulmonary hypertension. Expert Rev Cardiovasc Ther 4:293\u2013300. https:\/\/doi.org\/10.1586\/14779072.4.3.293","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"5543_CR36","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1093\/jnen\/60.9.906","volume":"60","author":"MT Heneka","year":"2001","unstructured":"Heneka MT, Wiesinger H, Dumitrescu-Ozimek L et al (2001) Neuronal and glial coexpression of argininosuccinate synthetase and inducible nitric oxide synthase in Alzheimer disease. J Neuropathol Exp Neurol 60:906\u2013916. https:\/\/doi.org\/10.1093\/jnen\/60.9.906","journal-title":"J Neuropathol Exp Neurol"},{"key":"5543_CR37","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nature11729","volume":"493","author":"MT Heneka","year":"2013","unstructured":"Heneka MT, Kummer MP, Stutz A et al (2013) NLRP3 is activated in Alzheimer\u2019s disease and contributes to pathology in APP\/PS1 mice. Nature 493:674\u2013678. https:\/\/doi.org\/10.1038\/nature11729","journal-title":"Nature"},{"key":"5543_CR38","doi-asserted-by":"publisher","first-page":"5113","DOI":"10.4049\/jimmunol.1202479","volume":"189","author":"E Hernandez-Cuellar","year":"2012","unstructured":"Hernandez-Cuellar E, Tsuchiya K, Hara H et al (2012) Cutting edge: nitric oxide inhibits the NLRP3 inflammasome. J Immunol 189:5113\u20135117. https:\/\/doi.org\/10.4049\/jimmunol.1202479","journal-title":"J Immunol"},{"key":"5543_CR39","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/j.1939-4640.2001.tb02188.x","volume":"22","author":"MB Herrero","year":"2001","unstructured":"Herrero MB, Gagnon C (2001) Nitric oxide: a novel mediator of sperm function. J Androl 22:349\u2013356. https:\/\/doi.org\/10.1002\/j.1939-4640.2001.tb02188.x","journal-title":"J Androl"},{"key":"5543_CR40","doi-asserted-by":"publisher","first-page":"4927","DOI":"10.1113\/JP280162","volume":"598","author":"RL Hoiland","year":"2020","unstructured":"Hoiland RL, Caldwell HG, Howe CA et al (2020) Nitric oxide is fundamental to neurovascular coupling in humans. J Physiol 598:4927\u20134939. https:\/\/doi.org\/10.1113\/JP280162","journal-title":"J Physiol"},{"key":"5543_CR41","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s00213-008-1200-1","volume":"200","author":"Y Hua","year":"2008","unstructured":"Hua Y, Huang X-Y, Zhou L et al (2008) DETA\/NONOate, a nitric oxide donor, produces antidepressant effects by promoting hippocampal neurogenesis. Psychopharmacology 200:231\u2013242. https:\/\/doi.org\/10.1007\/s00213-008-1200-1","journal-title":"Psychopharmacology"},{"key":"5543_CR42","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1002\/glia.22276","volume":"60","author":"R Huizinga","year":"2012","unstructured":"Huizinga R, Van Der Star BJ, Kipp M et al (2012) Phagocytosis of neuronal debris by microglia is associated with neuronal damage in multiple sclerosis. Glia 60:422\u2013431. https:\/\/doi.org\/10.1002\/glia.22276","journal-title":"Glia"},{"key":"5543_CR43","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1046\/j.1471-4159.2003.01841.x","volume":"86","author":"D Hyun","year":"2003","unstructured":"Hyun D, Lee M, Halliwell B, Jenner P (2003) Proteasomal inhibition causes the formation of protein aggregates containing a wide range of proteins, including nitrated proteins. J Neurochem 86:363\u2013373. https:\/\/doi.org\/10.1046\/j.1471-4159.2003.01841.x","journal-title":"J Neurochem"},{"key":"5543_CR44","doi-asserted-by":"publisher","unstructured":"Jaffrey SR, Snyder SH (2001) The biotin switch method for the detection of S -nitrosylated proteins. Sci STKE 2001:. https:\/\/doi.org\/10.1126\/stke.2001.86.pl1","DOI":"10.1126\/stke.2001.86.pl1"},{"key":"5543_CR45","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s12079-021-00663-x","volume":"16","author":"AFO Justo","year":"2022","unstructured":"Justo AFO, Suemoto CK (2022) The modulation of neuroinflammation by inducible nitric oxide synthase. J Cell Commun Signal 16:155\u2013158. https:\/\/doi.org\/10.1007\/s12079-021-00663-x","journal-title":"J Cell Commun Signal"},{"key":"5543_CR46","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1042\/BST0330701","volume":"33","author":"K Kashfi","year":"2005","unstructured":"Kashfi K, Rigas B (2005) Molecular targets of nitric-oxide-donating aspirin in cancer. Biochem Soc Trans 33:701\u2013704. https:\/\/doi.org\/10.1042\/BST0330701","journal-title":"Biochem Soc Trans"},{"key":"5543_CR47","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s00401-005-1019-3","volume":"110","author":"S Kato","year":"2005","unstructured":"Kato S, Kato M, Abe Y et al (2005) Redox system expression in the motor neurons in amyotrophic lateral sclerosis (ALS): immunohistochemical studies on sporadic ALS, superoxide dismutase 1 (SOD1)-mutated familial ALS, and SOD1-mutated ALS animal models. Acta Neuropathol 110:101\u2013112. https:\/\/doi.org\/10.1007\/s00401-005-1019-3","journal-title":"Acta Neuropathol"},{"key":"5543_CR48","doi-asserted-by":"publisher","first-page":"4122","DOI":"10.4049\/jimmunol.161.8.4122","volume":"161","author":"YM Kim","year":"1998","unstructured":"Kim YM, Talanian RV, Li J, Billiar TR (1998) Nitric oxide prevents IL-1beta and IFN-gamma-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1beta-converting enzyme). J Immunol 161:4122\u20134128","journal-title":"J Immunol"},{"key":"5543_CR49","doi-asserted-by":"publisher","first-page":"873","DOI":"10.3389\/fimmu.2017.00873","volume":"8","author":"N Kopitar-Jerala","year":"2017","unstructured":"Kopitar-Jerala N (2017) The role of interferons in inflammation and inflammasome activation. Front Immunol 8:873. https:\/\/doi.org\/10.3389\/fimmu.2017.00873","journal-title":"Front Immunol"},{"key":"5543_CR50","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0006-8993(02)02307-7","volume":"933","author":"DM Kuhn","year":"2002","unstructured":"Kuhn DM, Geddes TJ (2002) Reduced nicotinamide nucleotides prevent nitration of tyrosine hydroxylase by peroxynitrite. Brain Res 933:85\u201389. https:\/\/doi.org\/10.1016\/S0006-8993(02)02307-7","journal-title":"Brain Res"},{"key":"5543_CR51","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.neuron.2011.07.001","volume":"71","author":"MP Kummer","year":"2011","unstructured":"Kummer MP, Hermes M, Delekarte A et al (2011) Nitration of tyrosine 10 critically enhances amyloid \u03b2 aggregation and plaque formation. Neuron 71:833\u2013844. https:\/\/doi.org\/10.1016\/j.neuron.2011.07.001","journal-title":"Neuron"},{"key":"5543_CR52","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1146\/annurev-cellbio-101011-155745","volume":"28","author":"M Lamkanfi","year":"2012","unstructured":"Lamkanfi M, Dixit VM (2012) Inflammasomes and their roles in health and disease. Annu Rev Cell Dev Biol 28:137\u2013161. https:\/\/doi.org\/10.1146\/annurev-cellbio-101011-155745","journal-title":"Annu Rev Cell Dev Biol"},{"key":"5543_CR53","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","volume":"157","author":"M Lamkanfi","year":"2014","unstructured":"Lamkanfi M, Dixit VM (2014) Mechanisms and functions of inflammasomes. Cell 157:1013\u20131022. https:\/\/doi.org\/10.1016\/j.cell.2014.04.007","journal-title":"Cell"},{"key":"5543_CR54","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.neuint.2007.08.008","volume":"52","author":"TR Larsen","year":"2008","unstructured":"Larsen TR, S\u00f6derling A-S, Caidahl K et al (2008) Nitration of soluble proteins in organotypic culture models of Parkinson\u2019s disease. Neurochem Int 52:487\u2013494. https:\/\/doi.org\/10.1016\/j.neuint.2007.08.008","journal-title":"Neurochem Int"},{"key":"5543_CR55","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.cnr.2006.09.006","volume":"6","author":"R Lee Mosley","year":"2006","unstructured":"Lee Mosley R, Benner EJ, Kadiu I et al (2006) Neuroinflammation, oxidative stress, and the pathogenesis of Parkinson\u2019s disease. Clin Neurosci Res 6:261\u2013281. https:\/\/doi.org\/10.1016\/j.cnr.2006.09.006","journal-title":"Clin Neurosci Res"},{"issue":"1","key":"5543_CR56","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1186\/s12935-024-03568-y","volume":"24","author":"F Liang","year":"2024","unstructured":"Liang F, Wang M, Li J, Guo J (2024) The evolution of S-nitrosylation detection methodology and the role of protein S-nitrosylation in various cancers. Cancer Cell Int 24:408. https:\/\/doi.org\/10.1186\/s12935-024-03568-y","journal-title":"Cancer Cell Int"},{"key":"5543_CR57","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1038\/70978","volume":"5","author":"GT Liberatore","year":"1999","unstructured":"Liberatore GT, Jackson-Lewis V, Vukosavic S et al (1999) Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat Med 5:1403\u20131409. https:\/\/doi.org\/10.1038\/70978","journal-title":"Nat Med"},{"key":"5543_CR58","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1177\/1535370221997052","volume":"246","author":"PM Liy","year":"2021","unstructured":"Liy PM, Puzi NNA, Jose S, Vidyadaran S (2021) Nitric oxide modulation in neuroinflammation and the role of mesenchymal stem cells. Exp Biol Med (Maywood) 246:2399\u20132406. https:\/\/doi.org\/10.1177\/1535370221997052","journal-title":"Exp Biol Med (Maywood)"},{"key":"5543_CR59","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.729201","volume":"12","author":"CF Louren\u00e7o","year":"2021","unstructured":"Louren\u00e7o CF, Laranjinha J (2021) Nitric oxide pathways in neurovascular coupling under normal and stress conditions in the brain: strategies to rescue aberrant coupling and improve cerebral blood flow. Front Physiol 12:729201. https:\/\/doi.org\/10.3389\/fphys.2021.729201","journal-title":"Front Physiol"},{"key":"5543_CR60","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1523\/JNEUROSCI.17-07-02645.1997","volume":"17","author":"PL Malen","year":"1997","unstructured":"Malen PL, Chapman PF (1997) Nitric oxide facilitates long-term potentiation, but not long-term depression. J Neurosci 17:2645\u20132651. https:\/\/doi.org\/10.1523\/JNEUROSCI.17-07-02645.1997","journal-title":"J Neurosci"},{"key":"5543_CR61","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.2741\/2130","volume":"12","author":"C Mancuso","year":"2007","unstructured":"Mancuso C (2007) Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders. Front Biosci 12:1107. https:\/\/doi.org\/10.2741\/2130","journal-title":"Front Biosci"},{"key":"5543_CR62","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/nrd.2018.97","volume":"17","author":"MSJ Mangan","year":"2018","unstructured":"Mangan MSJ, Olhava EJ, Roush WR et al (2018) Targeting the NLRP3 inflammasome in inflammatory diseases. Nat Rev Drug Discov 17:588\u2013606. https:\/\/doi.org\/10.1038\/nrd.2018.97","journal-title":"Nat Rev Drug Discov"},{"key":"5543_CR63","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/cr.2013.6","volume":"23","author":"K Mao","year":"2013","unstructured":"Mao K, Chen S, Chen M et al (2013) Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. Cell Res 23:201\u2013212. https:\/\/doi.org\/10.1038\/cr.2013.6","journal-title":"Cell Res"},{"key":"5543_CR64","doi-asserted-by":"publisher","first-page":"12231","DOI":"10.1016\/S0021-9258(18)31375-9","volume":"268","author":"MA Marletta","year":"1993","unstructured":"Marletta MA (1993) Nitric oxide synthase structure and mechanism. J Biol Chem 268:12231\u201312234","journal-title":"J Biol Chem"},{"key":"5543_CR65","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","volume":"10","author":"F Martinon","year":"2002","unstructured":"Martinon F, Burns K, Tschopp J (2002) The inflammasome. Mol Cell 10:417\u2013426. https:\/\/doi.org\/10.1016\/S1097-2765(02)00599-3","journal-title":"Mol Cell"},{"key":"5543_CR66","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1002\/ana.10728","volume":"54","author":"PL McGeer","year":"2003","unstructured":"McGeer PL, Schwab C, Parent A, Doudet D (2003) Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration. Ann Neurol 54:599\u2013604. https:\/\/doi.org\/10.1002\/ana.10728","journal-title":"Ann Neurol"},{"key":"5543_CR67","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1172\/JCI119750","volume":"100","author":"T Michel","year":"1997","unstructured":"Michel T, Feron O (1997) Nitric oxide synthases: which, where, how, and why? J Clin Invest 100:2146\u20132152. https:\/\/doi.org\/10.1172\/JCI119750","journal-title":"J Clin Invest"},{"key":"5543_CR68","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1002\/med.21636","volume":"40","author":"R Minhas","year":"2020","unstructured":"Minhas R, Bansal Y, Bansal G (2020) Inducible nitric oxide synthase inhibitors: a comprehensive update. Med Res Rev 40:823\u2013855. https:\/\/doi.org\/10.1002\/med.21636","journal-title":"Med Res Rev"},{"key":"5543_CR69","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/ni.2474","volume":"14","author":"BB Mishra","year":"2013","unstructured":"Mishra BB, Rathinam VAK, Martens GW et al (2013) Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome\u2013dependent processing of IL-1\u03b2. Nat Immunol 14:52\u201360. https:\/\/doi.org\/10.1038\/ni.2474","journal-title":"Nat Immunol"},{"key":"5543_CR70","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","volume":"43","author":"S Moncada","year":"1991","unstructured":"Moncada S, Palmer RM, Higgs EA (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109\u2013142","journal-title":"Pharmacol Rev"},{"key":"5543_CR71","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1523\/JNEUROSCI.1574-03.2004","volume":"24","author":"B Moreno-L\u00f3pez","year":"2004","unstructured":"Moreno-L\u00f3pez B, Romero-Grimaldi C, Noval JA et al (2004) Nitric oxide is a physiological inhibitor of neurogenesis in the adult mouse subventricular zone and olfactory bulb. J Neurosci 24:85\u201395. https:\/\/doi.org\/10.1523\/JNEUROSCI.1574-03.2004","journal-title":"J Neurosci"},{"key":"5543_CR72","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1056\/NEJMsa063904","volume":"355","author":"F Murad","year":"2006","unstructured":"Murad F (2006) Nitric oxide and cyclic GMP in cell signaling and drug development. N Engl J Med 355:2003\u20132011. https:\/\/doi.org\/10.1056\/NEJMsa063904","journal-title":"N Engl J Med"},{"key":"5543_CR73","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1016\/S0278-6915(02)00169-2","volume":"40","author":"T Nakagawa","year":"2002","unstructured":"Nakagawa T, Yokozawa T (2002) Direct scavenging of nitric oxide and superoxide by green tea. Food Chem Toxicol 40:1745\u20131750. https:\/\/doi.org\/10.1016\/S0278-6915(02)00169-2","journal-title":"Food Chem Toxicol"},{"key":"5543_CR74","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s10495-008-0301-y","volume":"14","author":"T Nakamura","year":"2009","unstructured":"Nakamura T, Lipton SA (2009) Cell death: protein misfolding and neurodegenerative diseases. Apoptosis 14:455\u2013468. https:\/\/doi.org\/10.1007\/s10495-008-0301-y","journal-title":"Apoptosis"},{"key":"5543_CR75","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.neuron.2013.05.005","volume":"78","author":"T Nakamura","year":"2013","unstructured":"Nakamura T, Tu S, Akhtar MW et al (2013) Aberrant protein S-nitrosylation in neurodegenerative diseases. Neuron 78:596\u2013614. https:\/\/doi.org\/10.1016\/j.neuron.2013.05.005","journal-title":"Neuron"},{"key":"5543_CR76","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1126\/science.1110647","volume":"308","author":"A Nimmerjahn","year":"2005","unstructured":"Nimmerjahn A, Kirchhoff F, Helmchen F (2005) Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308:1314\u20131318. https:\/\/doi.org\/10.1126\/science.1110647","journal-title":"Science"},{"key":"5543_CR77","doi-asserted-by":"publisher","first-page":"9566","DOI":"10.1073\/pnas.1633579100","volume":"100","author":"MA Packer","year":"2003","unstructured":"Packer MA, Stasiv Y, Benraiss A et al (2003) Nitric oxide negatively regulates mammalian adult neurogenesis. Proc Natl Acad Sci U S A 100:9566\u20139571. https:\/\/doi.org\/10.1073\/pnas.1633579100","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5543_CR78","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1016\/j.freeradbiomed.2006.08.010","volume":"41","author":"M Pehar","year":"2006","unstructured":"Pehar M, Vargas MR, Robinson KM et al (2006) Peroxynitrite transforms nerve growth factor into an apoptotic factor for motor neurons. Free Radic Biol Med 41:1632\u20131644. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2006.08.010","journal-title":"Free Radic Biol Med"},{"key":"5543_CR79","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1016\/j.bbadis.2018.11.007","volume":"1865","author":"P Pic\u00f3n-Pag\u00e8s","year":"2019","unstructured":"Pic\u00f3n-Pag\u00e8s P, Garcia-Buendia J, Mu\u00f1oz FJ (2019) Functions and dysfunctions of nitric oxide in brain. Biochimica Et Biophysica Acta (BBA) - Molecular Basis of Disease 1865:1949\u20131967. https:\/\/doi.org\/10.1016\/j.bbadis.2018.11.007","journal-title":"Biochimica Et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"key":"5543_CR80","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.cmet.2017.06.018","volume":"26","author":"T Pr\u00f3chnicki","year":"2017","unstructured":"Pr\u00f3chnicki T, Latz E (2017) Inflammasomes on the crossroads of innate immune recognition and metabolic control. Cell Metab 26:71\u201393. https:\/\/doi.org\/10.1016\/j.cmet.2017.06.018","journal-title":"Cell Metab"},{"key":"5543_CR81","doi-asserted-by":"publisher","first-page":"4565","DOI":"10.1073\/pnas.93.10.4565","volume":"93","author":"S Przedborski","year":"1996","unstructured":"Przedborski S, Jackson-Lewis V, Yokoyama R et al (1996) Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity. Proc Natl Acad Sci U S A 93:4565\u20134571. https:\/\/doi.org\/10.1073\/pnas.93.10.4565","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5543_CR82","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1021\/acs.jproteome.5b00857","volume":"15","author":"Z Qu","year":"2016","unstructured":"Qu Z, Greenlief CM, Gu Z (2016) Quantitative proteomic approaches for analysis of protein S -nitrosylation. J Proteome Res 15:1\u201314. https:\/\/doi.org\/10.1021\/acs.jproteome.5b00857","journal-title":"J Proteome Res"},{"key":"5543_CR83","doi-asserted-by":"publisher","unstructured":"Rothstein JD (2009) Current hypotheses for the underlying biology of amyotrophic lateral sclerosis. Annals of Neurology 65:. https:\/\/doi.org\/10.1002\/ana.21543","DOI":"10.1002\/ana.21543"},{"key":"5543_CR84","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3233\/ADR-200166","volume":"4","author":"O Sanders","year":"2020","unstructured":"Sanders O (2020) Sildenafil for the treatment of Alzheimer\u2019s disease: a systematic review. J Alzheimers Dis Rep 4:91\u2013106. https:\/\/doi.org\/10.3233\/ADR-200166","journal-title":"J Alzheimers Dis Rep"},{"key":"5543_CR85","doi-asserted-by":"publisher","first-page":"271","DOI":"10.4161\/viru.20328","volume":"3","author":"DO Schairer","year":"2012","unstructured":"Schairer DO, Chouake JS, Nosanchuk JD, Friedman AJ (2012) The potential of nitric oxide releasing therapies as antimicrobial agents. Virulence 3:271\u2013279. https:\/\/doi.org\/10.4161\/viru.20328","journal-title":"Virulence"},{"key":"5543_CR86","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s10787-007-0013-x","volume":"15","author":"JN Sharma","year":"2007","unstructured":"Sharma JN, Al-Omran A, Parvathy SS (2007) Role of nitric oxide in inflammatory diseases. Inflammopharmacol 15:252\u2013259. https:\/\/doi.org\/10.1007\/s10787-007-0013-x","journal-title":"Inflammopharmacol"},{"key":"5543_CR87","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02988-3","volume":"20","author":"RI Sienel","year":"2023","unstructured":"Sienel RI, Mamrak U, Biller J et al (2023) Inhaled nitric oxide suppresses neuroinflammation in experimental ischemic stroke. J Neuroinflammation 20:301. https:\/\/doi.org\/10.1186\/s12974-023-02988-3","journal-title":"J Neuroinflammation"},{"key":"5543_CR88","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.niox.2024.01.006","volume":"145","author":"BD Silva","year":"2024","unstructured":"Silva BD, Viero FT, Rodrigues P, Trevisan G (2024) Nitric oxide involvement in the disability and active disease of multiple sclerosis: systematic review and meta-analysis. Nitric Oxide 145:8\u201320. https:\/\/doi.org\/10.1016\/j.niox.2024.01.006","journal-title":"Nitric Oxide"},{"key":"5543_CR89","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1179\/135100005X38842","volume":"10","author":"S Singh","year":"2005","unstructured":"Singh S, Das T, Ravindran A et al (2005) Involvement of nitric oxide in neurodegeneration: a study on the experimental models of Parkinson\u2019s disease. Redox Rep 10:103\u2013109. https:\/\/doi.org\/10.1179\/135100005X38842","journal-title":"Redox Rep"},{"key":"5543_CR90","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.niox.2021.10.008","volume":"118","author":"E Sircar","year":"2022","unstructured":"Sircar E, Stoyanovsky DA, Billiar TR et al (2022) Analysis of glutathione mediated S-(de)nitrosylation in complex biological matrices by immuno-spin trapping and identification of two novel substrates. Nitric Oxide 118:26\u201330. https:\/\/doi.org\/10.1016\/j.niox.2021.10.008","journal-title":"Nitric Oxide"},{"key":"5543_CR91","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/S1474-4422(02)00102-3","volume":"1","author":"KJ Smith","year":"2002","unstructured":"Smith KJ, Lassmann H (2002) The role of nitric oxide in multiple sclerosis. Lancet Neurol 1:232\u2013241. https:\/\/doi.org\/10.1016\/S1474-4422(02)00102-3","journal-title":"Lancet Neurol"},{"key":"5543_CR92","doi-asserted-by":"publisher","first-page":"3883","DOI":"10.1097\/00001756-200011270-00055","volume":"11","author":"S Smith","year":"2000","unstructured":"Smith S, Dringenberg HC, Bennett BM et al (2000) A novel nitrate ester reverses the cognitive impairment caused by scopolamine in the Morris water maze. Neuroreport 11:3883\u20133886. https:\/\/doi.org\/10.1097\/00001756-200011270-00055","journal-title":"Neuroreport"},{"key":"5543_CR93","doi-asserted-by":"publisher","first-page":"8071","DOI":"10.1007\/s12035-016-0297-1","volume":"54","author":"M Sochocka","year":"2017","unstructured":"Sochocka M, Diniz BS, Leszek J (2017) Inflammatory response in the CNS: friend or foe? Mol Neurobiol 54:8071\u20138089. https:\/\/doi.org\/10.1007\/s12035-016-0297-1","journal-title":"Mol Neurobiol"},{"key":"5543_CR94","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/S0092-8674(01)00495-0","volume":"106","author":"JS Stamler","year":"2001","unstructured":"Stamler JS, Lamas S, Fang FC (2001) Nitrosylation. Cell 106:675\u2013683. https:\/\/doi.org\/10.1016\/S0092-8674(01)00495-0","journal-title":"Cell"},{"key":"5543_CR95","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.freeradbiomed.2022.11.035","volume":"194","author":"JR Steinert","year":"2023","unstructured":"Steinert JR, Amal H (2023) The contribution of an imbalanced redox signalling to neurological and neurodegenerative conditions. Free Radic Biol Med 194:71\u201383. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.11.035","journal-title":"Free Radic Biol Med"},{"key":"5543_CR96","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1177\/1073858410366481","volume":"16","author":"JR Steinert","year":"2010","unstructured":"Steinert JR, Chernova T, Forsythe ID (2010) Nitric oxide signaling in brain function, dysfunction, and dementia. Neuroscientist 16:435\u2013452. https:\/\/doi.org\/10.1177\/1073858410366481","journal-title":"Neuroscientist"},{"key":"5543_CR97","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094771","volume":"22","author":"L Subedi","year":"2021","unstructured":"Subedi L, Gaire BP, Kim S-Y, Parveen A (2021) Nitric oxide as a target for phytochemicals in anti-neuroinflammatory prevention therapy. IJMS 22:4771. https:\/\/doi.org\/10.3390\/ijms22094771","journal-title":"IJMS"},{"key":"5543_CR98","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.nbd.2009.12.004","volume":"37","author":"MG Tansey","year":"2010","unstructured":"Tansey MG (2010) Inflammation in neuropsychiatric disease. Neurobiol Dis 37:491\u2013492. https:\/\/doi.org\/10.1016\/j.nbd.2009.12.004","journal-title":"Neurobiol Dis"},{"key":"5543_CR99","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/0005-2736(67)90060-0","volume":"135","author":"KF Tipton","year":"1967","unstructured":"Tipton KF (1967) The sub-mitochondrial localization of monoamine oxidase in rat liver and brain. Biochimica Et Biophysica Acta (BBA) - Biomembranes 135:910\u2013920. https:\/\/doi.org\/10.1016\/0005-2736(67)90060-0","journal-title":"Biochimica Et Biophysica Acta (BBA) - Biomembranes"},{"key":"5543_CR100","doi-asserted-by":"publisher","first-page":"11510","DOI":"10.1021\/jf103258p","volume":"58","author":"S-J Tsai","year":"2010","unstructured":"Tsai S-J, Kuo W-W, Liu W-H, Yin M-C (2010) Antioxidative and anti-inflammatory protection from carnosine in the striatum of MPTP-treated mice. J Agric Food Chem 58:11510\u201311516. https:\/\/doi.org\/10.1021\/jf103258p","journal-title":"J Agric Food Chem"},{"key":"5543_CR101","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.niox.2010.11.002","volume":"25","author":"T Uehara","year":"2011","unstructured":"Uehara T, Nishiya T (2011) Screening systems for the identification of S-nitrosylated proteins. Nitric Oxide 25:108\u2013111. https:\/\/doi.org\/10.1016\/j.niox.2010.11.002","journal-title":"Nitric Oxide"},{"key":"5543_CR102","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201810248","volume":"11","author":"S Voet","year":"2019","unstructured":"Voet S, Srinivasan S, Lamkanfi M, Van Loo G (2019) Inflammasomes in neuroinflammatory and neurodegenerative diseases. EMBO Mol Med 11:e10248. https:\/\/doi.org\/10.15252\/emmm.201810248","journal-title":"EMBO Mol Med"},{"key":"5543_CR103","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.neuron.2005.01.011","volume":"45","author":"H-G Wang","year":"2005","unstructured":"Wang H-G, Lu F-M, Jin I et al (2005) Presynaptic and postsynaptic roles of NO, cGK, and RhoA in long-lasting potentiation and aggregation of synaptic proteins. Neuron 45:389\u2013403. https:\/\/doi.org\/10.1016\/j.neuron.2005.01.011","journal-title":"Neuron"},{"key":"5543_CR104","doi-asserted-by":"publisher","DOI":"10.1039\/c2lc40132k","volume":"12","author":"S Wang","year":"2012","unstructured":"Wang S, Njoroge SK, Battle K et al (2012) Two-dimensional nitrosylated protein fingerprinting by using poly (methyl methacrylate) microchips. Lab Chip 12:3362. https:\/\/doi.org\/10.1039\/c2lc40132k","journal-title":"Lab Chip"},{"key":"5543_CR105","doi-asserted-by":"publisher","first-page":"3699","DOI":"10.1074\/jbc.271.7.3699","volume":"271","author":"N Willmott","year":"1996","unstructured":"Willmott N, Sethi JK, Walseth TF et al (1996) Nitric oxide-induced mobilization of intracellular calcium via the cyclic ADP-ribose signaling pathway. J Biol Chem 271:3699\u20133705. https:\/\/doi.org\/10.1074\/jbc.271.7.3699","journal-title":"J Biol Chem"},{"key":"5543_CR106","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103240","volume":"75","author":"M Wu","year":"2024","unstructured":"Wu M, Yu S, Yan S et al (2024) Peroxynitrite reduces Treg cell expansion and function by mediating IL-2R nitration and aggravates multiple sclerosis pathogenesis. Redox Biol 75:103240. https:\/\/doi.org\/10.1016\/j.redox.2024.103240","journal-title":"Redox Biol"},{"key":"5543_CR107","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1158\/0008-5472.CAN-06-2149","volume":"67","author":"L Ying","year":"2007","unstructured":"Ying L, Hofseth LJ (2007) An emerging role for endothelial nitric oxide synthase in chronic inflammation and cancer. Cancer Res 67:1407\u20131410. https:\/\/doi.org\/10.1158\/0008-5472.CAN-06-2149","journal-title":"Cancer Res"},{"key":"5543_CR108","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1080\/17482960600881870","volume":"7","author":"H Yoshino","year":"2006","unstructured":"Yoshino H, Kimura A (2006) Investigation of the therapeutic effects of edaravone, a free radical scavenger, on amyotrophic lateral sclerosis (Phase II study). Amyotroph Lateral Scler 7:247\u2013251. https:\/\/doi.org\/10.1080\/17482960600881870","journal-title":"Amyotroph Lateral Scler"},{"key":"5543_CR109","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00322","author":"JE Yuste","year":"2015","unstructured":"Yuste JE, Tarragon E, Campuzano CM, Ros-Bernal F (2015a) Implications of glial nitric oxide in neurodegenerative diseases. Front Cell Neurosci. https:\/\/doi.org\/10.3389\/fncel.2015.00322","journal-title":"Front Cell Neurosci"},{"key":"5543_CR110","doi-asserted-by":"publisher","unstructured":"Yuste JE, Tarragon E, Campuzano CM, Ros-Bernal F (2015b) Implications of glial nitric oxide in neurodegenerative diseases. Front Cell Neurosci 9:. https:\/\/doi.org\/10.3389\/fncel.2015.00322","DOI":"10.3389\/fncel.2015.00322"},{"key":"5543_CR111","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1523\/JNEUROSCI.23-01-00223.2003","volume":"23","author":"DY Zhu","year":"2003","unstructured":"Zhu DY, Liu SH, Sun HS, Lu YM (2003) Expression of inducible nitric oxide synthase after focal cerebral ischemia stimulates neurogenesis in the adult rodent dentate gyrus. J Neurosci 23:223\u2013229. https:\/\/doi.org\/10.1523\/JNEUROSCI.23-01-00223.2003","journal-title":"J Neurosci"},{"key":"5543_CR112","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.jns.2007.01.039","volume":"257","author":"X Zhu","year":"2007","unstructured":"Zhu X, Smith MA, Honda K et al (2007) Vascular oxidative stress in Alzheimer disease. J Neurol Sci 257:240\u2013246. https:\/\/doi.org\/10.1016\/j.jns.2007.01.039","journal-title":"J Neurol Sci"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05543-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05543-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05543-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:00:09Z","timestamp":1787670009000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05543-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,9]]},"references-count":112,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["5543"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05543-y","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,9]]},"assertion":[{"value":"11 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This article is a narrative review based on previously published studies and does not include any new research involving human participants or animals performed by the authors. Ethics approval was therefore not required.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This is not applicable, as this study did not involve human participants.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This is not applicable, as this study did not involve individual patient data or images.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors did not use generative artificial intelligence tools in the preparation of this manuscript.","order":5,"name":"Ethics","label":"Use of artificial intelligence tools","group":{"name":"EthicsHeading","label":"Declarations"}}]}}