{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:01:31Z","timestamp":1789981291199,"version":"4.0.1"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s00210-026-05544-x","type":"journal-article","created":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T02:06:07Z","timestamp":1782612367000},"page":"19761-19788","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Resveratrol-loaded novasomal gel for sustained dermal delivery against monobenzone-induced vitiligo-like depigmentation in black chicks"],"prefix":"10.1007","volume":"399","author":[{"given":"Fatma I. Abo","family":"El-Ela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein M.","family":"Eid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid Hamdy","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha","family":"Ragab Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel-Razik H.","family":"Abdel-Razik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salwa","family":"Baroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Eskander","family":"Attia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed G.","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed G. K.","family":"Habib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,28]]},"reference":[{"key":"5544_CR1","first-page":"8","volume":"4","author":"IS Ahmed","year":"2014","unstructured":"Ahmed IS, El Hosayb R, Shalabyb S, Noura S (2014) Preparation and in-vitro evaluation of poly-caprolactone nanoparticles containing atorvastatin calcium. J Pharm Res Opin 4:8\u201318","journal-title":"J Pharm Res Opin"},{"issue":"13","key":"5544_CR2","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.1093\/bioinformatics\/btv082","volume":"31","author":"A Alhossary","year":"2015","unstructured":"Alhossary A, Handoko SD, Mu Y, Kwoh CK (2015) Fast, accurate, and reliable molecular docking with QuickVina 2. Bioinformatics 31(13):2214\u20136. https:\/\/doi.org\/10.1093\/bioinformatics\/btv082","journal-title":"Bioinformatics"},{"issue":"6","key":"5544_CR3","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/nrd2060","volume":"5","author":"JA Baur","year":"2006","unstructured":"Baur JA, Sinclair DA (2006) Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 5(6):493\u2013506. https:\/\/doi.org\/10.1038\/nrd2060","journal-title":"Nat Rev Drug Discov"},{"issue":"3","key":"5544_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/neuro.08.001.2009","volume":"27","author":"JM Bessa","year":"2009","unstructured":"Bessa JM, Mesquita AR, Oliveira M, P\u00eago JM, Cerqueira JJ, Palha JA, Almeida OF, Sousa N (2009) A trans-dimensional approach to the behavioral aspects of depression. Front Behav Neurosci 27(3):1. https:\/\/doi.org\/10.3389\/neuro.08.001.2009.","journal-title":"Front Behav Neurosci"},{"issue":"1","key":"5544_CR5","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.beproc.2008.12.018","volume":"81","author":"M Campler","year":"2009","unstructured":"Campler M, J\u00f6ngren M, Jensen P (2009) Fearfulness in red junglefowl and domesticated White Leghorn chickens. Behav Processes 81(1):39\u201343. https:\/\/doi.org\/10.1016\/j.beproc.2008.12.018","journal-title":"Behav Processes"},{"issue":"6","key":"5544_CR6","doi-asserted-by":"publisher","first-page":"936","DOI":"10.3390\/cells12060936","volume":"12","author":"WL Chang","year":"2023","unstructured":"Chang WL, Ko CH (2023) The role of oxidative stress in vitiligo: an update on its pathogenesis and therapeutic implications. Cells 12(6):936. https:\/\/doi.org\/10.3390\/cells12060936","journal-title":"Cells"},{"key":"5544_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/632121","volume":"2013","author":"YJ Chen","year":"2013","unstructured":"Chen YJ, Chen YY, Lin YF, Hu HY, Liao HF (2013) Resveratrol inhibits alpha-melanocyte-stimulating hormone signaling, viability, and invasiveness in melanoma cells. Evid Based Complement Alternat Med 2013:1. https:\/\/doi.org\/10.1155\/2013\/632121","journal-title":"Evid Based Complement Alternat Med"},{"issue":"6","key":"5544_CR8","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.3390\/ijms20061381.PMID:30893846;PMCID:PMC6471659","volume":"20","author":"A Chimento","year":"2019","unstructured":"Chimento A, De Amicis F, Sirianni R, Sinicropi MS, Puoci F, Casaburi I, Saturnino C, Pezzi V (2019) Progress to improve oral bioavailability and beneficial effects of resveratrol. Int J Mol Sci 20(6):1381. https:\/\/doi.org\/10.3390\/ijms20061381.PMID:30893846;PMCID:PMC6471659","journal-title":"Int J Mol Sci"},{"issue":"18","key":"5544_CR9","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.2147\/CCID.S543849.PMID:40948611;PMCID:PMC12433249","volume":"9","author":"Q Cui","year":"2025","unstructured":"Cui Q, Wang H (2025) Resveratrol in dermatological therapy: a critical review of mechanisms, delivery innovations, and clinical frontiers. Clin Cosmet Investig Dermatol 9(18):2229\u20132242. https:\/\/doi.org\/10.2147\/CCID.S543849.PMID:40948611;PMCID:PMC12433249","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"5544_CR10","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.beproc.2013.11.002","volume":"103","author":"CL Daigle","year":"2014","unstructured":"Daigle CL, Siegford JM (2014) When continuous observations just won\u2019t do: developing accurate and efficient sampling strategies for the laying hen. Behav Processes 103:58\u201366. https:\/\/doi.org\/10.1016\/j.beproc.2013.11.002","journal-title":"Behav Processes"},{"issue":"5","key":"5544_CR11","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1034\/j.1600-0749.2003.00087.x","volume":"16","author":"ML Dell'Anna","year":"2003","unstructured":"Dell\u2019Anna ML, Urbanelli S, Mastrofrancesco A, Camera E, Iacovelli P, Leone G, Manini P, D\u2019Ischia M, Picardo M (2003) Alterations of mitochondria in peripheral blood mononuclear cells of vitiligo patients. Pigment Cell Res 16(5):553\u2013559. https:\/\/doi.org\/10.1034\/j.1600-0749.2003.00087.x","journal-title":"Pigment Cell Res"},{"key":"5544_CR12","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1038\/jid.2014.65","volume":"134","author":"L Denat","year":"2014","unstructured":"Denat L, Kadekaro AL, Marrot L, Leachman SA, Abdel-Malek ZA (2014) Melanocyte oxidative stress susceptibility. J Invest Dermatol 134:1512\u20131518","journal-title":"J Invest Dermatol"},{"key":"5544_CR13","doi-asserted-by":"crossref","unstructured":"Eid HM, Elkomy MH, El Menshawe SF, Salem HF (2019) Development, optimization, and in vitro\/in vivo characterization of enhanced lipid nanoparticles for ocular delivery of ofloxacin: the influence of pegylation and chitosan coating. AAPS PharmSciTech 20(5):183","DOI":"10.1208\/s12249-019-1371-6"},{"issue":"00","key":"5544_CR14","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/s0378-5173(00)00493-2","volume":"5173","author":"GM El Maghraby","year":"2000","unstructured":"El Maghraby GM, Williams AC, Barry BW (2000) Skin delivery of oestradiol from lipid vesicles: importance of liposome structure. Int J Pharm 5173(00):159\u201369. https:\/\/doi.org\/10.1016\/s0378-5173(00)00493-2","journal-title":"Int J Pharm"},{"key":"5544_CR15","doi-asserted-by":"crossref","unstructured":"Ezzedine K, Eleftheriadou V, Whitton M (2015) Vitiligo. Lancet 386(9988):74\u201384","DOI":"10.1016\/S0140-6736(14)60763-7"},{"issue":"9","key":"5544_CR16","doi-asserted-by":"publisher","first-page":"2936","DOI":"10.3390\/molecules27092936","volume":"27","author":"I Fatima","year":"2022","unstructured":"Fatima I, Rasul A, Shah S, Saadullah M, Islam N, Khames A, Salawi A, Ahmed MM, Almoshari Y, Abbas G (2022) Novasomes as nano-vesicular carriers to enhance topical delivery of fluconazole: a new approach to treat fungal infections. Molecules 27(9):2936, 2936","journal-title":"Molecules"},{"key":"5544_CR17","first-page":"103","volume":"8","author":"JM Faure","year":"1983","unstructured":"Faure JM, Jones RB (1983) Fear and social motivation as factors in open-field behaviour of the domestic chick. A theoretical consideration. Biol Behav 8:103\u2013116","journal-title":"Biol Behav"},{"key":"5544_CR18","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.applanim.2016.03.002","volume":"179","author":"GA Fraess","year":"2016","unstructured":"Fraess GA, Bench CJ (2016) Automated behavioural response assessment to a feeding event in two heritage chicken breeds. Appl Anim Behav Sci 179:74\u201381","journal-title":"Appl Anim Behav Sci"},{"issue":"5","key":"5544_CR19","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1111\/j.1751-553X.2008.01081.x","volume":"31","author":"T Ghys","year":"2009","unstructured":"Ghys T, Malfait R, Vandenbossche J (2009) Performance evaluation of the Sysmex XS-1000i automated haematology analyser. Int J Lab Hematol 31(5):560\u2013566. https:\/\/doi.org\/10.1111\/j.1751-553X.2008.01081.x","journal-title":"Int J Lab Hematol"},{"key":"5544_CR20","doi-asserted-by":"publisher","unstructured":"G\u00fcl\u00e7in I (2010) Antioxidant properties of resveratrol: a structure\u2013activity insight. https:\/\/doi.org\/10.1016\/j.ifset.2009.07.002","DOI":"10.1016\/j.ifset.2009.07.002"},{"issue":"5\u20106","key":"5544_CR21","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1002\/(SICI)1096-987X(199604)17:5\/6<490::AID-JCC1>3.0.CO;2-P","volume":"17","author":"TA Halgren","year":"1996","unstructured":"Halgren TA (1996) Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF94. J Comput Chem 17(5\u20106):490\u2013519","journal-title":"J Comput Chem"},{"issue":"1","key":"5544_CR22","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/jid.2009.214","volume":"130","author":"V Hariharan","year":"2010","unstructured":"Hariharan V, Klarquist J, Reust MJ, Koshoffer A, McKee MD, Boissy RE, Le Poole IC (2010) Monobenzyl ether of hydroquinone and 4-tertiary butyl phenol activate markedly different physiological responses in melanocytes: relevance to skin depigmentation. J Invest Dermatol 130(1):211\u2013220. https:\/\/doi.org\/10.1038\/jid.2009.214","journal-title":"J Invest Dermatol"},{"issue":"E1","key":"5544_CR23","doi-asserted-by":"publisher","first-page":"E8","DOI":"10.1038\/skinbio.2011.4","volume":"131","author":"VJ Hearing","year":"2011","unstructured":"Hearing VJ (2011) Determination of melanin synthetic pathways. J Invest Dermatol. 131(E1):E8\u2013E11. https:\/\/doi.org\/10.1038\/skinbio.2011.4","journal-title":"J Invest Dermatol."},{"issue":"1","key":"5544_CR24","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1046\/j.1365-2133.2001.03952.x","volume":"144","author":"K Jimbow","year":"2001","unstructured":"Jimbow K, Chen H, Park JS, Thomas PD (2001) Increased sensitivity of melanocytes to oxidative stress and abnormal expression of tyrosinase-related protein in vitiligo. Br J Dermatol 144(1):55\u201365. https:\/\/doi.org\/10.1046\/j.1365-2133.2001.03952.x","journal-title":"Br J Dermatol"},{"issue":"7873","key":"5544_CR25","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","volume":"596","author":"J Jumper","year":"2021","unstructured":"Jumper J, Evans R, Pritzel A, Green T, Figurnov M, Ronneberger O, Tunyasuvunakool K, Bates R, \u017d\u00eddek A, Potapenko A, Bridgland A, Meyer C, Kohl SAA, Ballard AJ, Cowie A, Romera-Paredes B, Nikolov S, Jain R, Adler J, Back T, Petersen S, Reiman D, Clancy E, Zielinski M, Steinegger M, Pacholska M, Berghammer T, Bodenstein S, Silver D, Vinyals O, Senior AW, Kavukcuoglu K, Kohli P, Hassabis D (2021) Highly accurate protein structure prediction with AlphaFold. Nature 596(7873):583\u2013589. https:\/\/doi.org\/10.1038\/s41586-021-03819-2","journal-title":"Nature"},{"issue":"15","key":"5544_CR26","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1007\/s00018-005-5054-y","volume":"62","author":"YJ Kim","year":"2005","unstructured":"Kim YJ, Uyama H (2005) Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future. Cell Mol Life Sci 62(15):1707\u201323. https:\/\/doi.org\/10.1007\/s00018-005-5054-y","journal-title":"Cell Mol Life Sci"},{"issue":"11","key":"5544_CR27","doi-asserted-by":"publisher","first-page":"4999","DOI":"10.3390\/ijms26114999","volume":"26","author":"S Kim","year":"2025","unstructured":"Kim S, Jhin C, Lee S, Rho HS, Park CY (2025) Effects of resveratrol derivatives on melanogenesis and antioxidant activity in B16F10 cells. Int J Mol Sci 26(11):4999, 4999. https:\/\/doi.org\/10.3390\/ijms26114999","journal-title":"Int J Mol Sci"},{"issue":"7","key":"5544_CR28","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1016\/s0968-0896(00)00102-4","volume":"8","author":"I Kubo","year":"2000","unstructured":"Kubo I, Kinst-Hori I, Chaudhuri SK, Kubo Y, S\u00e1nchez Y, Ogura T (2000) Flavonols from Heterotheca inuloides: tyrosinase inhibitory activity and structural criteria. Bioorg Med Chem 8(7):1749\u20131755. https:\/\/doi.org\/10.1016\/s0968-0896(00)00102-4","journal-title":"Bioorg Med Chem"},{"issue":"3","key":"5544_CR29","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1208\/s12249-013-9986-5","volume":"14","author":"D Kumbhar","year":"2013","unstructured":"Kumbhar D, Wavikar P, Vavia P (2013) Niosomal gel of lornoxicam for topical delivery: in vitro assessment and pharmacodynamic activity. AAPS PharmSciTech 14(3):1072\u201382. https:\/\/doi.org\/10.1208\/s12249-013-9986-5","journal-title":"AAPS PharmSciTech"},{"key":"5544_CR30","doi-asserted-by":"publisher","unstructured":"\u00a0Laddha NC, Dwivedi M, Mansuri MS, Gani AR, Ansarullah M, Ramachandran AV, Dalai S, Begum R (2013) Vitiligo: interplay between oxidative stress and immune system. Exp Dermatol 22(4):245\u201350. https:\/\/doi.org\/10.1111\/exd.12103","DOI":"10.1111\/exd.12103"},{"key":"5544_CR31","unstructured":"Landrum G, Tosco P, Kelley B, Rodriguez R, Cosgrove D, Vianello R, Gedeck P, Jones G, Kawashima E, Nealschneider D, and Dalke A (2024) rdkit\/rdkit: 2024_09_1 (Q3 2024) Release Beta. Zenodo"},{"issue":"7130","key":"5544_CR32","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/nature05660","volume":"445","author":"JY Lin","year":"2007","unstructured":"Lin JY, Fisher DE (2007) Melanocyte biology and skin pigmentation. Nature 445(7130):843\u2013850. https:\/\/doi.org\/10.1038\/nature05660","journal-title":"Nature"},{"issue":"1\u20133","key":"5544_CR33","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/s0169-409x(00)00129-0","volume":"46","author":"CA Lipinski","year":"2001","unstructured":"Lipinski CA, Lombardo F, Dominy BW, Feeney PJ (2001) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 46(1\u20133):3\u201326. https:\/\/doi.org\/10.1016\/s0169-409x(00)00129-0.","journal-title":"Adv Drug Deliv Rev"},{"issue":"5","key":"5544_CR34","doi-asserted-by":"publisher","first-page":"469","DOI":"10.2174\/1389200218666170222152038","volume":"18","author":"M Lucia","year":"2017","unstructured":"Lucia M (2017) Lipid-based nanoparticles as carriers for dermal delivery of antioxidants. Curr Drug Metab 18(5):469\u2013480. https:\/\/doi.org\/10.2174\/1389200218666170222152038.","journal-title":"Curr Drug Metab"},{"issue":"8","key":"5544_CR35","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1021\/tx900018q","volume":"22","author":"P Manini","year":"2009","unstructured":"Manini P, Napolitano A, Westerhof W, Riley PA, d\u2019Ischia M (2009) A reactive ortho-quinone generated by tyrosinase-catalyzed oxidation of the skin depigmenting agent monobenzone: self-coupling and thiol-conjugation reactions and possible implications for melanocyte toxicity. Chem Res Toxicol 22(8):1398\u20131405. https:\/\/doi.org\/10.1021\/tx900018q","journal-title":"Chem Res Toxicol"},{"key":"5544_CR36","first-page":"235","volume":"11","author":"AD Mills","year":"1986","unstructured":"Mills AD, Faure JM (1986) The estimation of fear in domestic quail: correlations between various methods and measures. Biol Behav 11:235\u2013243","journal-title":"Biol Behav"},{"issue":"16","key":"5544_CR37","doi-asserted-by":"publisher","first-page":"119","DOI":"10.2147\/IJN.S287383.PMID:33447031;PMCID:PMC7802774","volume":"8","author":"S Mosallam","year":"2021","unstructured":"Mosallam S, Ragaie MH, Moftah NH, Elshafeey AH, Abdelbary AA (2021) Use of novasomes as a vesicular carrier for improving the topical delivery of terconazole: in vitro characterization, in vivo assessment and exploratory clinical experimentation. Int J Nanomedicine 8(16):119\u2013132. https:\/\/doi.org\/10.2147\/IJN.S287383.PMID:33447031;PMCID:PMC7802774","journal-title":"Int J Nanomedicine"},{"issue":"2","key":"5544_CR38","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1111\/pcmr.12208","volume":"27","author":"JA Mosenson","year":"2014","unstructured":"Mosenson JA, Flood K, Klarquist J, Eby JM, Koshoffer A, Boissy RE, Overbeck A, Tung RC, Le Poole IC (2014) Preferential secretion of inducible HSP70 by vitiligo melanocytes under stress. Pigment Cell Melanoma Res 27(2):209\u201320. https:\/\/doi.org\/10.1111\/pcmr.12208","journal-title":"Pigment Cell Melanoma Res"},{"key":"5544_CR39","doi-asserted-by":"publisher","unstructured":"Mukherjee S, Dudley JI, Das DK (2010) Dose-dependency of resveratrol in providing health benefits. Dose Response 8(4):478\u2013500. https:\/\/doi.org\/10.2203\/dose-response.09-015.Mukherjee","DOI":"10.2203\/dose-response.09-015.Mukherjee"},{"issue":"1","key":"5544_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1468-3083.2005.01369.x","volume":"20","author":"K Ongenae","year":"2006","unstructured":"Ongenae K, Beelaert L, van Geel N (2006) Psychosocial effects of vitiligo. J Eur Acad Dermatol Venereol 20(1):1\u20138","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"5544_CR41","first-page":"253","volume":"3","author":"AN Patel","year":"2016","unstructured":"Patel AN, Prajapati BG (2016) Design and development of solid lipid nanoparticles (SLNs) of zolmitriptan for the treatment of migraine. Eur J Biomed Pharm Sci 3:253\u2013259","journal-title":"Eur J Biomed Pharm Sci"},{"issue":"3","key":"5544_CR42","first-page":"326","volume":"28","author":"M Picardo","year":"2015","unstructured":"Picardo M, Dell\u2019Anna ML, Ezzedine K et al (2015) Vitiligo pathogenesis: an update. Pigment Cell Melanoma Res 28(3):326\u2013337","journal-title":"Pigment Cell Melanoma Res"},{"key":"5544_CR43","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.applanim.2015.11.007","volume":"174","author":"K Pichova","year":"2016","unstructured":"Pichova K, Nordgreen J, Leterrier C, Kostal L (2016) The effects of food-related environmental complexity on litter directed behaviour, fear and exploration of novel stimuli in young broiler chickens. Appl Anim Behav Sci 174:83\u201389","journal-title":"Appl Anim Behav Sci"},{"issue":"6","key":"5544_CR44","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1093\/ps\/82.6.861","volume":"82","author":"TB Rodenburg","year":"2003","unstructured":"Rodenburg TB, Buitenhuis AJ, Ask B, Uitdehaag KA, Koene P, van der Poel JJ, Bovenhuis H (2003) Heritability of feather pecking and open-field response of laying hens at two different ages. Poult Sci 82(6):861\u20137. https:\/\/doi.org\/10.1093\/ps\/82.6.861","journal-title":"Poult Sci"},{"issue":"6","key":"5544_CR45","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1096\/fj.11-197137","volume":"26","author":"KU Schallreuter","year":"2012","unstructured":"Schallreuter KU, Salem MA, Gibbons NC, Martinez A, Slominski R, L\u00fcdemann J, Rokos H (2012a) Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry part 1: epidermal H2O2\/ONOO(\u2013)-mediated stress abrogates tryptophan hydroxylase and dopa decarboxylase activities leading to low serotonin and melatonin levels. FASEB J 26(6):2457\u20132470. https:\/\/doi.org\/10.1096\/fj.11-197137","journal-title":"FASEB J"},{"issue":"6","key":"5544_CR46","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1096\/fj.11-201897","volume":"26","author":"KU Schallreuter","year":"2012","unstructured":"Schallreuter KU, Salem MA, Gibbons NC, Maitland DJ, Marsch E, Elwary SM, Healey AR (2012b) Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry part 2: epidermal H2O2\/ONOO(-)-mediated stress in vitiligo hampers indoleamine 23-dioxygenase and aryl hydrocarbon receptor-mediated immune response signaling. FASEB J 26(6):2471\u20132485. https:\/\/doi.org\/10.1096\/fj.11-201897","journal-title":"FASEB J"},{"key":"5544_CR47","doi-asserted-by":"publisher","first-page":"434","DOI":"10.4103\/0250-474X.108419","volume":"74","author":"M Shah","year":"2012","unstructured":"Shah M, Agrawal YK, Garala K, Ramkishan A (2012) Solid lipid nanoparticles of a water soluble drug, ciprofloxacin hydrochloride. Indian J Pharm Sci 74:434\u201342","journal-title":"Indian J Pharm Sci"},{"issue":"23","key":"5544_CR48","doi-asserted-by":"publisher","first-page":"10286","DOI":"10.1039\/D3FO03065B","volume":"14","author":"PM Silva","year":"2023","unstructured":"Silva PM, Gon\u00e7alves C, Pastrana LM, Coimbra MA, Vicente AA (2023) Recent advances in oral delivery systems of resveratrol: foreseeing their use in functional foods. Food Funct 14(23):10286\u201310313","journal-title":"Food Funct"},{"key":"5544_CR49","doi-asserted-by":"publisher","unstructured":"Slominski A, Tobin DJ, Shibahara S, Wortsman J (2004) Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev 84(4):1155\u20131228. https:\/\/doi.org\/10.1152\/physrev.00044.2003.","DOI":"10.1152\/physrev.00044.2003"},{"issue":"2","key":"5544_CR50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19020633","volume":"19","author":"F Solano","year":"2018","unstructured":"Solano F (2018) On the metal cofactor in the tyrosinase family. Int J Mol Sci 19(2):633. https:\/\/doi.org\/10.3390\/ijms19020633","journal-title":"Int J Mol Sci"},{"issue":"7","key":"5544_CR51","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1016\/j.jid.2017.01.033","volume":"137","author":"R Speeckaert","year":"2017","unstructured":"Speeckaert R, Voet S, Hoste E, van Geel N (2017) S100B is a potential disease activity marker in nonsegmental vitiligo. J Invest Dermatol 137(7):1445\u20131453. https:\/\/doi.org\/10.1016\/j.jid.2017.01.033","journal-title":"J Invest Dermatol"},{"key":"5544_CR52","unstructured":"Suvarna KS, Layton C (2018) Bancroft\u2019s theory and practice of histological techniques E-Book. Elsevier health sciences"},{"key":"5544_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.applanim.2020.105009","volume":"228","author":"FM Tahamtani","year":"2020","unstructured":"Tahamtani FM, Riber AB (2020) The effect of qualitative feed restriction in broiler breeder pullets on fear and motivation to explore. Appl Anim Behav Sci 228:105009","journal-title":"Appl Anim Behav Sci"},{"key":"5544_CR54","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1034\/j.1600-0749.13.s8.9.x","volume":"13","author":"A Ta\u00efeb","year":"2000","unstructured":"Ta\u00efeb A (2000) Intrinsic and extrinsic pathomechanisms in vitiligo. Pigment Cell Res 13:41\u201347","journal-title":"Pigment Cell Res"},{"issue":"D1","key":"5544_CR55","doi-asserted-by":"publisher","first-page":"D523","DOI":"10.1093\/nar\/gkac1052","volume":"51","author":"The UniProt Consortium","year":"2023","unstructured":"The UniProt Consortium (2023) UniProt: the universal protein knowledgebase in 2023. Nucleic Acids Res 51(D1):D523\u2013D531. https:\/\/doi.org\/10.1093\/nar\/gkac1052","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"5544_CR56","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"O Trott","year":"2010","unstructured":"Trott O, Olson AJ (2010) AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem 31(2):455\u201361. https:\/\/doi.org\/10.1002\/jcc.21334","journal-title":"J Comput Chem"},{"issue":"D1","key":"5544_CR57","doi-asserted-by":"publisher","first-page":"D439","DOI":"10.1093\/nar\/gkab1061","volume":"50","author":"M Varadi","year":"2022","unstructured":"Varadi M, Anyango S, Deshpande M, Nair S, Natassia C, Yordanova G, Yuan D, Stroe O, Wood G, Laydon A, \u017d\u00eddek A, Green T, Tunyasuvunakool K, Petersen S, Jumper J, Clancy E, Green R, Vora A, Lutfi M, Figurnov M, Cowie A, Hobbs N, Kohli P, Kleywegt G, Birney E, Hassabis D, Velankar S (2022) AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models. Nucleic Acids Res 50(D1):D439\u2013D444. https:\/\/doi.org\/10.1093\/nar\/gkab1061","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"5544_CR58","doi-asserted-by":"publisher","first-page":"2615","DOI":"10.1021\/jm020017n","volume":"45","author":"DF Veber","year":"2002","unstructured":"Veber DF, Johnson SR, Cheng HY, Smith BR, Ward KW, Kopple KD (2002) Molecular properties that influence the oral bioavailability of drug candidates. J Med Chem 45(12):2615\u201323. https:\/\/doi.org\/10.1021\/jm020017n","journal-title":"J Med Chem"},{"key":"5544_CR59","doi-asserted-by":"publisher","unstructured":"Walle T, Hsieh F, DeLegge MH, Oatis JJ Jr, Walle UK (2004) High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 32(12):1377\u20131382. https:\/\/doi.org\/10.1124\/dmd.104.000885","DOI":"10.1124\/dmd.104.000885"},{"key":"5544_CR60","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003263.pub5","volume":"2015","author":"ME Whitton","year":"2015","unstructured":"Whitton ME, Pinart M, Batchelor J, Leonardi-Bee J, Gonz\u00e1lez U, Jiyad Z, Eleftheriadou V, Ezzedine K (2015) Interventions for vitiligo. Cochrane Database Syst Rev 2015:CD003263. https:\/\/doi.org\/10.1002\/14651858.CD003263.pub5","journal-title":"Cochrane Database Syst Rev"},{"issue":"7","key":"5544_CR61","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1111\/exd.12184","volume":"22","author":"Y Zhu","year":"2013","unstructured":"Zhu Y, Wang S, Xu A (2013) A mouse model of vitiligo induced by monobenzone. Exp Dermatol 22(7):499\u2013501. https:\/\/doi.org\/10.1111\/exd.12184","journal-title":"Exp Dermatol"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05544-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05544-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05544-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:13:06Z","timestamp":1789978386000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05544-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,28]]},"references-count":61,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["5544"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05544-x","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,28]]},"assertion":[{"value":"13 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was ethically approved by Beni-Suef University and Use Committee of Beni-Suef University (BSU-PSAS-BSU-HAREC.025\/08\/03). No human participants were involved in this study and informed consent was not applicable. Also the authors declared that this study is following the BioMed Central editorial policies, and the ethical treatment were come in accordance with the ARRIVE guidelines\u2019.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors approved this version of the manuscript for publication.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declared no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}