{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:54:13Z","timestamp":1791536053389,"version":"4.3.4"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s00210-026-05548-7","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:04:39Z","timestamp":1781582679000},"page":"18933-18956","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the material basis and potential mechanism of spleen-strengthening and damp-resolving prescriptions in the treatment of diabetes mellitus complicated with obesity based on data mining, UPLC-Q-TOF\u2013MS\/MS and network pharmacology"],"prefix":"10.1007","volume":"399","author":[{"given":"Ruo","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinling","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"5548_CR1","doi-asserted-by":"publisher","unstructured":"Ablai D (2020) The effect of Xiaoke Jianpi Capsule on serum leptin in obese patients with type 2 diabetes mellitus of spleen deficiency and excessive dampness type. Master's thesis, Xinjiang Medical University, Urumqi, China. https:\/\/doi.org\/10.27433\/d.cnki.gxyku.2020.000976","DOI":"10.27433\/d.cnki.gxyku.2020.000976"},{"key":"5548_CR2","doi-asserted-by":"publisher","unstructured":"Abraham MJ et al (2015) GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers. SoftwareX 1\u20132:19\u201325.\u00a0https:\/\/doi.org\/10.1016\/j.softx.2015.06.001","DOI":"10.1016\/j.softx.2015.06.001"},{"key":"5548_CR3","unstructured":"Agrawal R, Srikant R (1994) Fast algorithms for mining association rules. Proceedings of the 20th International Conference on Very Large Data Bases, Santiago de Chile. Morgan Kaufmann,\u00a0Chile, pp 487\u2013499"},{"key":"5548_CR4","doi-asserted-by":"crossref","unstructured":"Amberger JS et al (2015) OMIM.org: Online Mendelian Inheritance in Man (OMIM(R)), an online catalog of human genes and genetic disorders. Nucleic Acids Res 43(Database issue): p. D789\u201398","DOI":"10.1093\/nar\/gku1205"},{"key":"5548_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157540","volume":"149","author":"J Bai","year":"2025","unstructured":"Bai J et al (2025) Codonopsis Radix: a comprehensive review for its ethnopharmacology, phytochemistry, pharmacodynamics, pharmacokinetics, toxicity and potential clinical applications. Phytomedicine 149:157540","journal-title":"Phytomedicine"},{"key":"5548_CR6","doi-asserted-by":"publisher","first-page":"359","DOI":"10.2147\/ITT.S499605","volume":"14","author":"A Berbudi","year":"2025","unstructured":"Berbudi A, Khairani S, Tjahjadi A (2025) Interplay between insulin resistance and immune dysregulation in type 2 diabetes mellitus: implications for therapeutic interventions. Immunotargets Ther 14:359\u2013382","journal-title":"Immunotargets Ther"},{"issue":"8","key":"5548_CR7","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13929","volume":"26","author":"S Berg","year":"2025","unstructured":"Berg S et al (2025) Discontinuing glucagon-like peptide-1 receptor agonists and body habitus: a systematic review and meta-analysis. Obes Rev 26(8):e13929","journal-title":"Obes Rev"},{"key":"5548_CR8","first-page":"1945","volume-title":"Pharmacopoeia of the People\u2019s Republic of China (Volume 1)","author":"China, P.C.o.t.P.s.R.o.","year":"2025","unstructured":"China, P.C.o.t.P.s.R.o. (2025) Pharmacopoeia of the People\u2019s Republic of China (Volume 1), 2025 ed. China Medical Science and Technology Press, Beijing, p 1945","edition":"2025 ed"},{"issue":"5","key":"5548_CR9","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1002\/ptr.2694","volume":"23","author":"JYW Chan","year":"2008","unstructured":"Chan JYW et al (2008) Antihyperglycemic and antioxidative effects of a herbal formulation of Radix Astragali, Radix Codonopsis and Cortex Lycii in a mouse model of type 2 diabetes mellitus. Phytother Res 23(5):658\u2013665","journal-title":"Phytother Res"},{"key":"5548_CR10","doi-asserted-by":"publisher","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"A Daina","year":"2017","unstructured":"Daina A, Michielin O, Zoete V (2017) SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Sci Rep 7:42717","journal-title":"Sci Rep"},{"issue":"17","key":"5548_CR11","first-page":"4812","volume":"48","author":"WC Dan","year":"2023","unstructured":"Dan WC, Zhao GZ, He QY, Zhang H, Li B, Zhang GZ (2023) Analysis and prospects of common problems in clinical data mining of traditional Chinese medicine prescriptions. CHINA JOURNAL OE CHINESE MATERIA MEDICA 48(17):4812\u20134818","journal-title":"CHINA JOURNAL OE CHINESE MATERIA MEDICA"},{"issue":"W1","key":"5548_CR12","doi-asserted-by":"publisher","first-page":"W357","DOI":"10.1093\/nar\/gkz382","volume":"47","author":"A Daina","year":"2019","unstructured":"Daina A, Michielin O, Zoete V (2019) SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules. Nucleic Acids Res 47(W1):W357\u2013W364","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"5548_CR13","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1016\/j.immuni.2025.09.011","volume":"58","author":"MY Donath","year":"2025","unstructured":"Donath MY, Drucker MYandDJ (2025) Obesity, diabetes, and inflammation: pathophysiology and clinical implications. Immunity 58(10):2373\u20132382","journal-title":"Immunity"},{"key":"5548_CR14","unstructured":"Editorial Board of *Zhonghua Bencao* (Chinese Materia Medica) under the National Administration of Traditional Chinese Medicine (1999) *Zhonghua Bencao* (Chinese Materia Medica). Shanghai Science and Technology Press, Shanghai"},{"issue":"1","key":"5548_CR15","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1080\/21623945.2020.1817278","volume":"9","author":"Z Feng","year":"2020","unstructured":"Feng Z, Zhu L, Wu J (2020) RAGE signalling in obesity and diabetes: focus on the adipose tissue macrophage. Adipocyte 9(1):563\u2013566","journal-title":"Adipocyte"},{"issue":"8","key":"5548_CR16","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1021\/acs.jcim.8b00312","volume":"58","author":"T Gaillard","year":"2013","unstructured":"Gaillard T (2013) Evaluation of AutoDock and AutoDock Vina on the CASF-2013 benchmark. J Chem Inf Model 58(8):1697\u20131706","journal-title":"J Chem Inf Model"},{"key":"5548_CR17","doi-asserted-by":"publisher","first-page":"155313","DOI":"10.1016\/j.phymed.2023.155313","volume":"128","author":"G Gao","year":"2024","unstructured":"Gao G et al (2024) Alisol B regulates AMPK\/mTOR\/SREBPs via directly targeting VDAC1 to alleviate hyperlipidemia. Phytomedicine 128:155313, 155313","journal-title":"Phytomedicine"},{"issue":"D1","key":"5548_CR18","doi-asserted-by":"publisher","first-page":"D1404","DOI":"10.1093\/nar\/gkae1037","volume":"53","author":"K Gao","year":"2025","unstructured":"Gao K et al (2025) HERB 2.0: an updated database integrating clinical and experimental evidence for traditional Chinese medicine. Nucleic Acids Res 53(D1):D1404\u2013D1414","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"5548_CR19","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1002\/pro.3730","volume":"29","author":"DS Goodsell","year":"2020","unstructured":"Goodsell DS et al (2020) RCSB Protein Data Bank: enabling biomedical research and drug discovery. Protein Sci 29(1):52\u201365","journal-title":"Protein Sci"},{"issue":"1","key":"5548_CR20","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/nmeth.4067","volume":"14","author":"J Huang","year":"2017","unstructured":"Huang J et al (2017) CHARMM36m: an improved force field for folded and intrinsically disordered proteins. Nat Methods 14(1):71\u201373","journal-title":"Nat Methods"},{"key":"5548_CR21","unstructured":"International Diabetes Federation (IDF) (2025) IDF Diabetes Atlas, 11th edn. International Diabetes Federation, Brussels, Belgium. https:\/\/diabetesatlas.org"},{"key":"5548_CR22","unstructured":"International Diabetes Federation, World Obesity Federation (2022) Obesity and Type 2 Diabetes: a Joint Approach to Halt the Rise [Policy Brief]. World Obesity Federation, London. Available from: https:\/\/idf.org\/media\/uploads\/2023\/05\/attachments-28.pdf"},{"key":"5548_CR23","first-page":"547","volume":"37","author":"P Jaccard","year":"1901","unstructured":"Jaccard P (1901) \u00c9tude comparative de la distribution florale dans une portion des Alpes et du Jura. Bulletin De La Soci\u00e9t\u00e9 Vaudoise des Sciences Naturelles 37:547\u2013579","journal-title":"Bulletin De La Soci\u00e9t\u00e9 Vaudoise des Sciences Naturelles"},{"key":"5548_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/foods11233941","author":"X Jing","year":"2022","unstructured":"Jing X et al (2022) A review of the effects of puerarin on glucose and lipid metabolism in metabolic syndrome: mechanisms and opportunities. Foods. https:\/\/doi.org\/10.3390\/foods11233941"},{"issue":"2","key":"5548_CR25","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1063\/1.445869","volume":"79","author":"WL Jorgensen","year":"1983","unstructured":"Jorgensen WL et al (1983) Comparison of simple potential functions for simulating liquid water. J Chem Phys 79(2):926\u2013935","journal-title":"J Chem Phys"},{"key":"5548_CR26","doi-asserted-by":"publisher","unstructured":"Kim B, Kim JungNam, Kim YunTai, Kim H et al (2019) The role of the herbal medicines, Rehmanniae radix, Citrus unshiu peel, and Poria cocos wolf, in high-fat diet-induced obesity. Pharmacogn Mag. https:\/\/doi.org\/10.4103\/pm.pm_376_18","DOI":"10.4103\/pm.pm_376_18"},{"issue":"D1","key":"5548_CR27","doi-asserted-by":"publisher","first-page":"D1516","DOI":"10.1093\/nar\/gkae1059","volume":"53","author":"S Kim","year":"2025","unstructured":"Kim S et al (2025) PubChem 2025 update. Nucleic Acids Res 53(D1):D1516\u2013D1525","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"5548_CR28","doi-asserted-by":"publisher","first-page":"D1265","DOI":"10.1093\/nar\/gkad976","volume":"52","author":"C Knox","year":"2024","unstructured":"Knox C et al (2024) DrugBank 6.0: the DrugBank knowledgebase for 2024. Nucleic Acids Res 52(D1):D1265\u2013D1275","journal-title":"Nucleic Acids Res"},{"key":"5548_CR29","doi-asserted-by":"publisher","DOI":"10.53388\/pd202404021","author":"J Li","year":"2024","unstructured":"Li J (2024) Chemical constituents, pharmacology and safety of isoflavones in Puerariae Lobatae Radix. Pharmacology Discovery. https:\/\/doi.org\/10.53388\/pd202404021","journal-title":"Pharmacology Discovery"},{"issue":"3","key":"5548_CR30","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s12272-024-01489-y","volume":"47","author":"YX Liu","year":"2024","unstructured":"Liu YX et al (2024) Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application. Arch Pharm Res 47(3):165\u2013218","journal-title":"Arch Pharm Res"},{"issue":"1","key":"5548_CR31","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s13059-019-1758-4","volume":"20","author":"D Otasek","year":"2019","unstructured":"Otasek D et al (2019) Cytoscape Automation: empowering workflow-based network analysis. Genome Biol 20(1):185","journal-title":"Genome Biol"},{"key":"5548_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e26863","author":"C Qu","year":"2024","unstructured":"Qu C et al (2024) A systematic review of astragaloside IV effects on animal models of diabetes mellitus and its complications. Heliyon. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e26863","journal-title":"Heliyon"},{"issue":"04","key":"5548_CR33","doi-asserted-by":"publisher","first-page":"e213","DOI":"10.1055\/s-0045-1814435","volume":"05","author":"W Shang","year":"2025","unstructured":"Shang W et al (2025) Research progress on chemical constituents and pharmacological effects of Zexie (Alismatis Rhizoma). Chinese Medicine and Natural Products 05(04):e213\u2013e225","journal-title":"Chinese Medicine and Natural Products"},{"key":"5548_CR34","doi-asserted-by":"publisher","DOI":"10.1007\/s40473-026-00319-3","author":"A Singh","year":"2026","unstructured":"Singh A, Singh L, Dalal D (2026) Mechanistic insights into the therapeutic potential of apigenin in Parkinson\u2019s disease: an in silico docking and ADMET study. Curr Behav Neurosci Rep. https:\/\/doi.org\/10.1007\/s40473-026-00319-3","journal-title":"Curr Behav Neurosci Rep"},{"key":"5548_CR35","unstructured":"Sokal RRM, CD (1958) A Statistical Method for Evaluating Systematic Relationships. Univ Kans Sci Bull 38(22): p. 1409\u20131438"},{"key":"5548_CR36","unstructured":"International Organization for Standardization (2017) Traditional Chinese medicine \u2014 vocabulary \u2014 Part 1: Chinese Materia Medica. ISO 18662-1:2017. ISO, Geneva. https:\/\/www.iso.org\/standard\/63148.html"},{"key":"5548_CR37","first-page":"1","volume":"54","author":"G Stelzer","year":"2016","unstructured":"Stelzer G et al (2016) The GeneCards suite: from gene data mining to disease genome sequence analyses. Curr Protoc Bioinformatics 54:1\u20131","journal-title":"Curr Protoc Bioinformatics"},{"issue":"3","key":"5548_CR38","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s11306-007-0082-2","volume":"3","author":"LW Sumner","year":"2007","unstructured":"Sumner LW et al (2007) Proposed minimum reporting standards for chemical analysis. Metabolomics 3(3):211\u2013221","journal-title":"Metabolomics"},{"issue":"D1","key":"5548_CR39","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk D et al (2023) The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res 51(D1):D638\u2013D646","journal-title":"Nucleic Acids Res"},{"key":"5548_CR40","first-page":"165","volume-title":"Huang di nei jing su wen","author":"DH Tian","year":"2017","unstructured":"Tian DH (2017) Huang di nei jing su wen. People\u2019s Medical Publishing House, BeiJing, p 165"},{"key":"5548_CR41","unstructured":"Tang XY, FG, Zhao XH (2013) Analysis of TCM syndromes frequency of obese type 2 diabetes. Clin J Chin Med 5(20): p. 115\u2013116"},{"key":"5548_CR42","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.biosystems.2014.11.005","volume":"127","author":"Y Tang","year":"2015","unstructured":"Tang Y et al (2015) CytoNCA: a cytoscape plugin for centrality analysis and evaluation of protein interaction networks. Biosystems 127:67\u201372","journal-title":"Biosystems"},{"key":"5548_CR43","unstructured":"The PyMOL Molecular Graphics System (2024) Version 3.0. Schr\u00f6dinger, LLC.https:\/\/pymol.org\/2\/"},{"issue":"D1","key":"5548_CR44","doi-asserted-by":"publisher","first-page":"D609","DOI":"10.1093\/nar\/gkae1010","volume":"53","author":"C UniProt","year":"2025","unstructured":"UniProt C (2025) UniProt: the Universal Protein Knowledgebase in 2025. Nucleic Acids Res 53(D1):D609\u2013D617","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"5548_CR45","doi-asserted-by":"publisher","first-page":"6281","DOI":"10.1021\/acs.jctc.1c00645","volume":"17","author":"MS Valdes-Tresanco","year":"2021","unstructured":"Valdes-Tresanco MS, Vald\u00e9s-Tresanco ME et al (2021) Gmx_MMPBSA: a new tool to perform end-state free energy calculations with GROMACS. J Chem Theory Comput 17(10):6281\u20136291","journal-title":"J Chem Theory Comput"},{"issue":"2","key":"5548_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/mmr.2025.13773","volume":"33","author":"W Tang","year":"2025","unstructured":"Tang W et al (2025) Influence and treatment of insulin receptor substrate\/PI3K\/Akt\u2011mediated insulin resistance in diabetes mellitus (Review). Mol Med Rep 33(2):1\u201313","journal-title":"Mol Med Rep"},{"key":"5548_CR47","doi-asserted-by":"publisher","DOI":"10.3390\/nu14050954","author":"L Wang","year":"2022","unstructured":"Wang L et al (2022) Mechanism of Astragalus membranaceus alleviating acquired hyperlipidemia induced by high-fat diet through regulating lipid metabolism. Nutrients. https:\/\/doi.org\/10.3390\/nu14050954","journal-title":"Nutrients"},{"key":"5548_CR48","unstructured":"Wang ZM, GH, FU XT (2006)\u00a0 Multi-components quantitation by onemarker new method for quality evaluation of Chinese herbal medicine. China J Chin Materia Medica (23): p. 1925\u20131928"},{"key":"5548_CR49","unstructured":"Wu WX, WY, Dai XJ, Deng L, Yao LQ, Ye LF (2024) Clinical Observation of Lingzhu Powder Combined with Metformin in the Treatment of Metabolic Syndrome with Spleen Deficiency and Dampness Obstruction Syndrome. China Pharm 33(11): p. 98\u2013101"},{"key":"5548_CR50","doi-asserted-by":"publisher","unstructured":"Xiong Q et al (2025) Progress in the study of bioactivity, chemical composition and pharmacological mechanism of action in Wolfiporia cocos (F.A. Wolf) Ryvarden & Gilb. Front Pharmacol 16:1521235. https:\/\/doi.org\/10.3389\/fphar.2025.1521235","DOI":"10.3389\/fphar.2025.1521235"},{"issue":"05","key":"5548_CR51","first-page":"171","volume":"41","author":"DY Yang","year":"2023","unstructured":"Yang DY, Yu H, Wu XY, Gong QF (2023) Research Progress on Chemical Constituents and Their Biological Activities of Baizhu( Atractylodis macrocephala). Chin Arch Tradit Chin Med 41(05):171\u2013182","journal-title":"Chin Arch Tradit Chin Med"},{"issue":"5","key":"5548_CR52","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G et al (2012) clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 16(5):284\u2013287","journal-title":"OMICS"},{"key":"5548_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118503","volume":"333","author":"X Zhang","year":"2024","unstructured":"Zhang X et al (2024) Phytochemistry, pharmacological properties and pharmacokinetics of Citri Reticulatae Pericarpium: A systematic review. J Ethnopharmacol 333:118503","journal-title":"J Ethnopharmacol"},{"issue":"24","key":"5548_CR54","doi-asserted-by":"publisher","first-page":"5121","DOI":"10.1093\/bioinformatics\/btz459","volume":"35","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Sanner YandMF (2019) Autodock crankpep: combining folding and docking to predict protein-peptide complexes. Bioinformatics 35(24):5121\u20135127","journal-title":"Bioinformatics"},{"key":"5548_CR55","doi-asserted-by":"crossref","unstructured":"Zheng ZG et al (2023) Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCepsilon signaling axis. Cell Metab\u00a035(1): p. 101\u2013117 e11","DOI":"10.1016\/j.cmet.2022.11.012"},{"key":"5548_CR56","doi-asserted-by":"publisher","unstructured":"Zhou H, Zhou B-J et al (2018) Ultra-high performance liquid chromatography\/triple quadrupole mass spectrometry study of the stabilities and transformations of four alisols in Alismatis Rhizoma and proprietary traditional Chinese medicine prescriptions. Pharmacogn Mag. https:\/\/doi.org\/10.4103\/pm.pm_614_17","DOI":"10.4103\/pm.pm_614_17"},{"issue":"D1","key":"5548_CR57","doi-asserted-by":"publisher","first-page":"D1465","DOI":"10.1093\/nar\/gkad751","volume":"52","author":"Y Zhou","year":"2024","unstructured":"Zhou Y et al (2024) TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res 52(D1):D1465\u2013D1477","journal-title":"Nucleic Acids Res"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05548-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05548-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05548-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:43:28Z","timestamp":1791535408000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05548-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,16]]},"references-count":57,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["5548"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05548-7","relation":{"references":[{"id-type":"doi","id":"10.3390\/foods11233941","asserted-by":"subject"}]},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,16]]},"assertion":[{"value":"3 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable, because China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP Chinese Science and Technology Journal Database and China Biomedical Literature Database (CBM) belong to public databases, the patients involved in the database have obtained ethical approval, users can download relevant data for free for research and publish relevant articles, and our study is based on open-source data, and the Guangzhou University of Chinese Medicine Huizhou Hospital do not require research using publicly available data to be submitted for review to their ethics committee, so there are no ethical issues and other conflicts of interest.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable, because this paper did not reveal any personal information of patients.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Conflict of interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}