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The pathophysiology of SUDEP involves structural fibrosis of the myocardium, a calcium imbalance, and dysfunction of the autonomic nervous system. The objective of this investigation was to examine cardiac damage resulting from epilepsy triggered by the Pentylenetetrazol (PTZ) kindling rat model at a dosage of 35\u00a0mg\/kg administered intraperitoneally, and to assess the therapeutic benefits of Resveratrol (RSV) at a dosage of 5\u00a0mg\/kg. Cardiac function was evaluated using isolated papillary muscle recordings. Damage to the structure was assessed by Sirius Red staining and general tissue morphology. Molecular analyses encompassed qPCR (SERCA2a, CACNA1G, HCN2, CAS3\/9) and immunofluorescence (SIRT1, Caspase-3, S100\u03b1) in conjunction with the total Ca\n                    <jats:sup>2<\/jats:sup>\n                    \u207a content. PTZ kindling enhanced seizure severity and overall spike number on ECoG. Functionally, contractile force (CF), contractile power (AUC), and contraction\/relaxation velocities (\u00b1\u2009dF\/dt\n                    <jats:sub>max<\/jats:sub>\n                    ) were decreased in the PTZ group compared to the Sham group at 3, 4, and 5\u00a0Hz frequencies. Contraction duration (CT) was significantly prolonged at 5\u00a0Hz, whereas no significant change was observed in relaxation time (RT). Histopathology revealed degeneration and substantial myocardial scarring. At a molecular level, PTZ decreased SERCA 2a mRNA expression (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) while increasing total calcium content (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) and pro-apoptotic markers (Caspase-3\/9). Furthermore, the protective SIRT1 protein signal intensity was substantially reduced. RSV therapy resulted in a reduction of seizure severity by 2.54\u2009\u00b1\u20090.13 and also ameliorated cardiac function. Mechanistically, RSV recovered expression of SERCA2a (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), reduced fibrosis\/apoptosis, and reactivated the anti-apoptotic SIRT1 pathway. These findings show that RSV ameliorates epilepsy-induced cardiac injury and has the potential to serve as an effective supportive treatment against SUDEP-related heart dysfunction by regulating calcium levels and activating anti-apoptotic pathways.\n                  <\/jats:p>","DOI":"10.1007\/s00210-026-05557-6","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T03:54:32Z","timestamp":1781063672000},"page":"18365-18382","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epilepsy-induced heart damage and sudep risk: ion channelopathies, calcium homeostasis, and the therapeutic potential of resveratrol"],"prefix":"10.1007","volume":"399","author":[{"given":"Nilufer","family":"Akgun-Unal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4816-830X","authenticated-orcid":false,"given":"Omer","family":"Unal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre Soner","family":"Tiryaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Akkoca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seda","family":"Simsek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Gulbahce-Mutlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Ayyildiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"issue":"4","key":"5557_CR1","doi-asserted-by":"publisher","first-page":"820","DOI":"10.58600\/eurjther1912","volume":"29","author":"A Ahmet","year":"2023","unstructured":"Ahmet A, Se\u00e7kin T (2023) The effect of MitoTEMPO on rat diaphragm muscle contraction parameters in an experimental diabetes model induced with streptozotocin. 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