{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:01:48Z","timestamp":1789981308256,"version":"4.0.1"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s00210-026-05608-y","type":"journal-article","created":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T02:30:08Z","timestamp":1782613808000},"page":"19809-19826","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pseudomonas aeruginosa ST4936 with extensive antibacterial drug resistance and virulence determinants from ureteral stent biofilms: whole-genome insights"],"prefix":"10.1007","volume":"399","author":[{"given":"Nargis","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rani","family":"Faryal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Hanif","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liaqat","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,28]]},"reference":[{"key":"5608_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10081533","volume":"10","author":"P Aguilar-Rodea","year":"2022","unstructured":"Aguilar-Rodea P, Estrada-Javier EL, Jim\u00e9nez-Rojas V et al (2022) New variants of Pseudomonas aeruginosa high-risk clone ST233 associated with an outbreak in a Mexican paediatric hospital. Microorganisms 10:1533. https:\/\/doi.org\/10.3390\/microorganisms10081533","journal-title":"Microorganisms"},{"key":"5608_CR2","doi-asserted-by":"crossref","unstructured":"Al-Nayyef H, Guyeux C, Petitjean M, et al (2015) Relation between insertion sequences and genome rearrangements in Pseudomonas aeruginosa. In: Bioinformatics and Biomedical Engineering (IWBBIO 2015). Springer, pp 426\u2013437","DOI":"10.1007\/978-3-319-16483-0_42"},{"key":"5608_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1563781","author":"A Alsaadi","year":"2025","unstructured":"Alsaadi A, Imam M, Alghamdi AA et al (2025) Genomic analysis of prophages in 44 clinical strains of Pseudomonas aeruginosa isolated in Saudi Arabia. Front Cell Infect Microbiol. https:\/\/doi.org\/10.3389\/fcimb.2025.1563781","journal-title":"Front Cell Infect Microbiol"},{"key":"5608_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.genrep.2025.102226","volume":"40","author":"A Alzaidi","year":"2025","unstructured":"Alzaidi A, Lajoie M, Kwon DH (2025) Differential roles of catalase-encoding genes (katA and katB) in response to oxidative stress and antibiotics in Pseudomonas aeruginosa. Gene Rep 40:102226. https:\/\/doi.org\/10.1016\/j.genrep.2025.102226","journal-title":"Gene Rep"},{"key":"5608_CR5","doi-asserted-by":"publisher","unstructured":"Amado P, Zheng S, Lange D, Carugo D, Waters SL, Obrist D, Burkhard F, Clavica F (2024) The interplay between bacterial biofilms, encrustation, and wall shear stress in ureteral stents: a review across scales. Front Urol 3:1335414. https:\/\/doi.org\/10.3389\/fruro.2023.1335414","DOI":"10.3389\/fruro.2023.1335414"},{"key":"5608_CR6","doi-asserted-by":"publisher","first-page":"W16","DOI":"10.1093\/nar\/gkw387","volume":"44","author":"D Arndt","year":"2016","unstructured":"Arndt D, Grant JR, Marcu A et al (2016) PHASTER: a better, faster version of the PHAST phage search tool. Nucleic Acids Res 44:W16\u2013W21. https:\/\/doi.org\/10.1093\/nar\/gkw387","journal-title":"Nucleic Acids Res"},{"key":"5608_CR7","doi-asserted-by":"publisher","first-page":"49","DOI":"10.5173\/ceju.2023.218","volume":"76","author":"V Bernasconi","year":"2023","unstructured":"Bernasconi V, Tozzi M, Pietropaolo A et al (2023) Comprehensive overview of ureteral stents based on clinical aspects, material and design. Cent European J Urol 76:49\u201356. https:\/\/doi.org\/10.5173\/ceju.2023.218","journal-title":"Cent European J Urol"},{"key":"5608_CR8","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/nbt.3893","volume":"35","author":"RM Bowers","year":"2017","unstructured":"Bowers RM, Kyrpides NC, Stepanauskas R et al (2017) Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea. Nat Biotechnol 35:725\u2013731","journal-title":"Nat Biotechnol"},{"key":"5608_CR9","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02629-17","author":"VM Ch\u00e1vez-Jacobo","year":"2018","unstructured":"Ch\u00e1vez-Jacobo VM, Hern\u00e1ndez-Ram\u00edrez KC, Romo-Rodr\u00edguez P et al (2018) CrpP is a novel ciprofloxacin-modifying enzyme encoded by the Pseudomonas aeruginosa pUM505 plasmid. Antimicrob Agents Chemother. https:\/\/doi.org\/10.1128\/AAC.02629-17","journal-title":"Antimicrob Agents Chemother"},{"key":"5608_CR10","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1016\/j.molp.2023.09.010","volume":"16","author":"C Chen","year":"2023","unstructured":"Chen C, Wu Y, Li J et al (2023a) TBtools-II: A \u201cone for all, all for one\u201d bioinformatics platform for biological big-data mining. Mol Plant 16:1733\u20131742. https:\/\/doi.org\/10.1016\/j.molp.2023.09.010","journal-title":"Mol Plant"},{"key":"5608_CR11","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12894-023-01339-x","volume":"23","author":"Q Chen","year":"2023","unstructured":"Chen Q, Ye J, Bin LX et al (2023b) Drug resistance and influencing factors of biofilm bacteria in upper urinary calculi patients with double J stent indwelling. BMC Urol 23:165. https:\/\/doi.org\/10.1186\/s12894-023-01339-x","journal-title":"BMC Urol"},{"issue":"5","key":"5608_CR12","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.00301-25","volume":"10","author":"ST Choudhury","year":"2025","unstructured":"Choudhury ST, Piper KR, Montoya-Giraldo M, Ikhimiukor OO, Dettman JR, Kassen R, Andam CP (2025) Heterogeneity in recombination rates and accessory gene co-occurrence distinguish Pseudomonas aeruginosa phylogroups. Msystems 10(5):e00301-25. https:\/\/doi.org\/10.1128\/msystems.00301-25","journal-title":"Msystems"},{"key":"5608_CR13","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3390\/antibiotics12010165","volume":"12","author":"A Chukamnerd","year":"2023","unstructured":"Chukamnerd A, Pomwised R, Chusri S et al (2023) Antimicrobial susceptibility and molecular features of colonizing isolates of Pseudomonas aeruginosa and the report of a novel sequence type (ST) 3910 from Thailand. Antibiotics 12:165. https:\/\/doi.org\/10.3390\/antibiotics12010165","journal-title":"Antibiotics"},{"key":"5608_CR14","volume-title":"Performance standards for antimicrobial susceptibility testing, 34th edition","author":"CLSI","year":"2024","unstructured":"CLSI (2024) Performance standards for antimicrobial susceptibility testing, 34th edition. Clinical and Laboratory Standards Institute, Wayne, PA"},{"key":"5608_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens14040387","volume":"14","author":"T De Sousa","year":"2025","unstructured":"De Sousa T, Wang H-Y, Lin T-W et al (2025) Mutational analysis of colistin-resistant Pseudomonas aeruginosa isolates: from genomic background to antibiotic resistance. Pathogens 14:387. https:\/\/doi.org\/10.3390\/pathogens14040387","journal-title":"Pathogens"},{"key":"5608_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14060530","volume":"14","author":"T Dechathai","year":"2025","unstructured":"Dechathai T, Singkhamanan K, Yaikhan T et al (2025) Comprehensive genomic analysis of Pseudomonas aeruginosa PSU9449 isolated from a clinical case in Thailand. Antibiotics 14:530. https:\/\/doi.org\/10.3390\/antibiotics14060530","journal-title":"Antibiotics"},{"issue":"3","key":"5608_CR17","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00766-22","volume":"10","author":"L Diorio-Toth","year":"2022","unstructured":"Diorio-Toth L, Irum S, Potter RF, Wallace MA, Arslan M, Munir T, Andleeb S, Burnham CA, Dantas G (2022) Genomic surveillance of clinical Pseudomonas aeruginosa isolates reveals an additive effect of carbapenemase production on carbapenem resistance. Microbiol Spectr 10(3):e00766-22. https:\/\/doi.org\/10.1128\/spectrum.00766-22","journal-title":"Microbiol Spectr"},{"issue":"2","key":"5608_CR18","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.001971","volume":"74","author":"H Ebrahim","year":"2025","unstructured":"Ebrahim H, Haldenby S, Moore MP, Dashti AA, Floyd RV, Fothergill JL (2025) Genotypic and phenotypic analyses of two distinct sets of Pseudomonas aeruginosa urinary tract isolates. J Med Microbiol 74(2):001971. https:\/\/doi.org\/10.1099\/jmm.0.001971","journal-title":"J Med Microbiol"},{"key":"5608_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1374466","author":"A Elfadadny","year":"2024","unstructured":"Elfadadny A, Ragab RF, AlHarbi M et al (2024) Antimicrobial resistance of Pseudomonas aeruginosa: navigating clinical impacts, current resistance trends, and innovations in breaking therapies. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2024.1374466","journal-title":"Front Microbiol"},{"key":"5608_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7120707","volume":"7","author":"DM Foulkes","year":"2019","unstructured":"Foulkes DM, McLean K, Haneef AS et al (2019) Pseudomonas aeruginosa toxin ExoU as a therapeutic target in the treatment of bacterial infections. Microorganisms 7:707. https:\/\/doi.org\/10.3390\/microorganisms7120707","journal-title":"Microorganisms"},{"key":"5608_CR21","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1093\/gbe\/evy259","volume":"11","author":"L Freschi","year":"2019","unstructured":"Freschi L, Vincent AT, Jeukens J et al (2019) The Pseudomonas aeruginosa pan-genome provides new insights on its population structure, horizontal gene transfer, and pathogenicity. Genome Biol Evol 11:109\u2013120. https:\/\/doi.org\/10.1093\/gbe\/evy259","journal-title":"Genome Biol Evol"},{"key":"5608_CR22","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3390\/antibiotics12010175","volume":"12","author":"L Galiot","year":"2023","unstructured":"Galiot L, Monger XC, Vincent AT (2023) Studying the association between antibiotic resistance genes and insertion sequences in metagenomes: challenges and pitfalls. Antibiotics (Basel) 12:175. https:\/\/doi.org\/10.3390\/antibiotics12010175","journal-title":"Antibiotics (Basel)"},{"key":"5608_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12050866","volume":"12","author":"J G\u00f3mez-Mart\u00ednez","year":"2023","unstructured":"G\u00f3mez-Mart\u00ednez J, Rocha-Gracia RdelC, Bello-L\u00f3pez E et al (2023) Comparative genomics of Pseudomonas aeruginosa strains isolated from different ecological niches. Antibiotics (Basel) 12:866. https:\/\/doi.org\/10.3390\/antibiotics12050866","journal-title":"Antibiotics (Basel)"},{"key":"5608_CR24","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1111\/j.1574-695X.2010.00703.x","volume":"59","author":"V Hol\u00e1","year":"2010","unstructured":"Hol\u00e1 V, Ruzicka F, Horka M (2010) Microbial diversity in biofilm infections of the urinary tract with the use of sonication techniques: table 1. FEMS Immunol Med Microbiol 59:525\u2013528. https:\/\/doi.org\/10.1111\/j.1574-695X.2010.00703.x","journal-title":"FEMS Immunol Med Microbiol"},{"key":"5608_CR25","doi-asserted-by":"publisher","first-page":"10874","DOI":"10.1038\/s41598-019-47303-4","volume":"9","author":"G Horna","year":"2019","unstructured":"Horna G, Amaro C, Palacios A et al (2019) High frequency of the exoU+\/exoS+ genotype associated with multidrug-resistant \u201chigh-risk clones\u201d of Pseudomonas aeruginosa clinical isolates from Peruvian hospitals. Sci Rep 9:10874. https:\/\/doi.org\/10.1038\/s41598-019-47303-4","journal-title":"Sci Rep"},{"issue":"12","key":"5608_CR26","doi-asserted-by":"publisher","first-page":"1373130","DOI":"10.3389\/fbioe.2024.1373130","volume":"20","author":"K Hu","year":"2024","unstructured":"Hu K, Hou Z, Huang Y, Li X, Li X, Yang L (2024) Recent development and future application of biodegradable ureteral stents. Front Bioeng Biotechnol 20(12):1373130. https:\/\/doi.org\/10.3389\/fbioe.2024.1373130","journal-title":"Front Bioeng Biotechnol"},{"key":"5608_CR27","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12941-023-00656-1","volume":"23","author":"Z Hu","year":"2024","unstructured":"Hu Z, Zhou L, Tao X et al (2024b) Antimicrobial resistance survey and whole-genome analysis of nosocomial P. aeruginosa isolated from eastern Province of China in 2016\u20132021. Ann Clin Microbiol Antimicrob 23:12. https:\/\/doi.org\/10.1186\/s12941-023-00656-1","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"5608_CR28","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01481-23","author":"LD Hultqvist","year":"2024","unstructured":"Hultqvist LD, Andersen JB, Nilsson CM et al (2024) High efficacy treatment of murine Pseudomonas aeruginosa catheter-associated urinary tract infections using the c-di-GMP modulating anti-biofilm compound Disperazol in combination with ciprofloxacin. Antimicrob Agents Chemother. https:\/\/doi.org\/10.1128\/aac.01481-23","journal-title":"Antimicrob Agents Chemother"},{"key":"5608_CR29","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10111386","volume":"10","author":"S Irum","year":"2021","unstructured":"Irum S, Naz K, Ullah N et al (2021) Antimicrobial resistance and genomic characterization of six new sequence types in multidrug-resistant Pseudomonas aeruginosa clinical isolates from Pakistan. Antibiotics (Basel) 10:1386. https:\/\/doi.org\/10.3390\/antibiotics10111386","journal-title":"Antibiotics (Basel)"},{"key":"5608_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07641-9","volume":"9","author":"C Jain","year":"2018","unstructured":"Jain C, Rodriguez-R LM, Phillippy AM et al (2018) High throughput ANI analysis of 90K prokaryotic genomes reveals clear species boundaries. Nat Commun 9:5114. https:\/\/doi.org\/10.1038\/s41467-018-07641-9","journal-title":"Nat Commun"},{"key":"5608_CR31","doi-asserted-by":"publisher","first-page":"D566","DOI":"10.1093\/nar\/gkw1004","volume":"45","author":"B Jia","year":"2017","unstructured":"Jia B, Raphenya AR, Alcock B et al (2017) CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res 45:D566\u2013D573. https:\/\/doi.org\/10.1093\/nar\/gkw1004","journal-title":"Nucleic Acids Res"},{"key":"5608_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11070850","volume":"11","author":"S Kaliyeva","year":"2022","unstructured":"Kaliyeva S, Simokhina N, Lavrinenko A et al (2022) Bacterial colonization incidence before and after indwelling double-J ureteral stents. Antibiotics (Basel) 11:850. https:\/\/doi.org\/10.3390\/antibiotics11070850","journal-title":"Antibiotics (Basel)"},{"key":"5608_CR33","doi-asserted-by":"publisher","first-page":"75","DOI":"10.4103\/jgid.jgid_276_21","volume":"14","author":"M Kar","year":"2022","unstructured":"Kar M, Dubey A, Patel SS et al (2022) Characteristics of bacterial colonization and urinary tract infection after indwelling of double-J ureteral stent and percutaneous nephrostomy tube. J Glob Infect Dis 14:75\u201380. https:\/\/doi.org\/10.4103\/jgid.jgid_276_21","journal-title":"J Glob Infect Dis"},{"key":"5608_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14040353","volume":"14","author":"T Karampatakis","year":"2025","unstructured":"Karampatakis T, Tsergouli K, Behzadi P (2025) Carbapenem-resistant Pseudomonas aeruginosa\u2019s resistome: pan-genomic plasticity, the impact of transposable elements and jumping genes. Antibiotics (Basel) 14:353. https:\/\/doi.org\/10.3390\/antibiotics14040353","journal-title":"Antibiotics (Basel)"},{"issue":"13","key":"5608_CR35","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.835403","volume":"14","author":"S Kiyaga","year":"2022","unstructured":"Kiyaga S, Kyany\u2019a C, Muraya AW, Smith HJ, Mills EG, Kibet C, Mboowa G, Musila L (2022) Genetic diversity, distribution, and genomic characterization of antibiotic resistance and virulence of clinical Pseudomonas aeruginosa strains in Kenya. Front Microbiol 14(13):835403. https:\/\/doi.org\/10.3389\/fmicb.2022.835403","journal-title":"Front Microbiol"},{"key":"5608_CR36","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.tim.2023.11.005","volume":"32","author":"T Krell","year":"2024","unstructured":"Krell T, Matilla MA (2024) Pseudomonas aeruginosa. Trends Microbiol 32:216\u2013218. https:\/\/doi.org\/10.1016\/j.tim.2023.11.005","journal-title":"Trends Microbiol"},{"key":"5608_CR37","doi-asserted-by":"publisher","first-page":"355","DOI":"10.54112\/bcsrj.v2023i1.355","volume":"2023","author":"J Kumar","year":"2023","unstructured":"Kumar J, Shaikh N, Samad A et al (2023) DJ stent colonization patterns: exploring microbial profiles and clinical relevance. Biologic Clinic Sci Res J 2023:355. https:\/\/doi.org\/10.54112\/bcsrj.v2023i1.355","journal-title":"Biologic Clinic Sci Res J"},{"key":"5608_CR38","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","volume":"18","author":"AP Magiorakos","year":"2012","unstructured":"Magiorakos AP, Srinivasan A, Carey RB et al (2012) Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect 18:268\u2013281. https:\/\/doi.org\/10.1111\/j.1469-0691.2011.03570.x","journal-title":"Clin Microbiol Infect"},{"key":"5608_CR39","doi-asserted-by":"publisher","first-page":"7023","DOI":"10.1097\/MS9.0000000000002683","volume":"86","author":"P Mainali","year":"2024","unstructured":"Mainali P, Luitel P, Paudel S et al (2024) Risk factors for bacterial stent colonization in patients with a double J ureteral stent: a prospective study. Ann Med Surg (Lond) 86:7023\u20137028. https:\/\/doi.org\/10.1097\/MS9.0000000000002683","journal-title":"Ann Med Surg (Lond)"},{"issue":"1","key":"5608_CR40","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1038\/s41467-019-10210-3","volume":"10","author":"JP Meier-Kolthoff","year":"2019","unstructured":"Meier-Kolthoff JP, G\u00f6ker M (2019) TYGS is an automated high-throughput platform for state-of-the-art genome-based taxonomy. Nat Commun 10(1):2182. https:\/\/doi.org\/10.1038\/s41467-019-10210-3","journal-title":"Nat Commun"},{"key":"5608_CR41","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1038\/s41579-024-01054-w","volume":"22","author":"WR Miller","year":"2024","unstructured":"Miller WR, Arias CA (2024) ESKAPE pathogens: antimicrobial resistance, epidemiology, clinical impact and therapeutics. Nat Rev Microbiol 22:598\u2013616. https:\/\/doi.org\/10.1038\/s41579-024-01054-w","journal-title":"Nat Rev Microbiol"},{"key":"5608_CR42","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1159\/000538002","volume":"33","author":"AS Mustafa","year":"2024","unstructured":"Mustafa AS (2024) Whole genome sequencing: applications in clinical bacteriology. Med Princ Pract 33:185\u2013197. https:\/\/doi.org\/10.1159\/000538002","journal-title":"Med Princ Pract"},{"issue":"1","key":"5608_CR43","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12866-021-02427-4","volume":"22","author":"S Nasrin","year":"2022","unstructured":"Nasrin S, Hegerle N, Sen S, Nkeze J, Sen S, Permala-Booth J, Choi M, Sinclair J, Tapia MD, Johnson JK, Sow SO (2022) Distribution of serotypes and antibiotic resistance of invasive Pseudomonas aeruginosa in a multi-country collection. BMC Microbiol 22(1):13. https:\/\/doi.org\/10.1186\/s12866-021-02427-4","journal-title":"BMC Microbiol"},{"key":"5608_CR44","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00489-20","author":"JM Ortiz de la Rosa","year":"2020","unstructured":"Ortiz de la Rosa JM, Nordmann P, Poirel L (2020) Pathogenicity genomic island-associated CrpP-like fluoroquinolone-modifying enzymes among Pseudomonas aeruginosa clinical isolates in Europe. Antimicrob Agents Chemother. https:\/\/doi.org\/10.1128\/AAC.00489-20","journal-title":"Antimicrob Agents Chemother"},{"key":"5608_CR45","doi-asserted-by":"publisher","DOI":"10.3390\/biotech14010021","volume":"14","author":"N Pajaro-Castro","year":"2025","unstructured":"Pajaro-Castro N, Diaz-Morales E, Hoyos K (2025) Genomic characterization of extremely antibiotic-resistant strains of Pseudomonas aeruginosa isolated from patients of a clinic in Sincelejo, Colombia. Biotech 14:21. https:\/\/doi.org\/10.3390\/biotech14010021","journal-title":"Biotech"},{"key":"5608_CR46","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1101\/gr.186072.114","volume":"25","author":"DH Parks","year":"2015","unstructured":"Parks DH, Imelfort M, Skennerton CT et al (2015) CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes. Genome Res 25:1043\u20131055. https:\/\/doi.org\/10.1101\/gr.186072.114","journal-title":"Genome Res"},{"key":"5608_CR47","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1111\/1574-6968.12445","volume":"356","author":"S Pohl","year":"2014","unstructured":"Pohl S, Klockgether J, Eckweiler D et al (2014) The extensive set of accessory Pseudomonas aeruginosa genomic components. FEMS Microbiol Lett 356:235\u2013241. https:\/\/doi.org\/10.1111\/1574-6968.12445","journal-title":"FEMS Microbiol Lett"},{"key":"5608_CR48","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/s41392-022-01056-1","volume":"7","author":"S Qin","year":"2022","unstructured":"Qin S, Xiao W, Zhou C et al (2022) Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics. Signal Transduct Target Ther 7:199. https:\/\/doi.org\/10.1038\/s41392-022-01056-1","journal-title":"Signal Transduct Target Ther"},{"key":"5608_CR49","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjac329","author":"M Rahoui","year":"2022","unstructured":"Rahoui M, Ouanes Y, Chaker K et al (2022) Life-threatening complication due to double-J stent: renal subcapsular hematoma. J Surg Case Rep. https:\/\/doi.org\/10.1093\/jscr\/rjac329","journal-title":"J Surg Case Rep"},{"key":"5608_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmni.2023.101082","volume":"51","author":"J Ruiz","year":"2023","unstructured":"Ruiz J, Ocampo K, Salvador-Luj\u00e1n G et al (2023) First report of CrpP prevalence in a South American country. New Microbes New Infect 51:101082. https:\/\/doi.org\/10.1016\/j.nmni.2023.101082","journal-title":"New Microbes New Infect"},{"key":"5608_CR51","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.65836","volume":"10","author":"A Sabnis","year":"2021","unstructured":"Sabnis A, Hagart KL, Kl\u00f6ckner A, Becce M, Evans LE, Furniss RC, Mavridou DA, Murphy R, Stevens MM, Davies JC, Larrouy-Maumus GJ (2021) Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane. Elife 10:e65836. https:\/\/doi.org\/10.7554\/eLife.65836","journal-title":"Elife"},{"key":"5608_CR52","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-024-09585-6","volume":"24","author":"N Saeli","year":"2024","unstructured":"Saeli N, Jafari-Ramedani S, Ramazanzadeh R et al (2024) Prevalence and mechanisms of aminoglycoside resistance among drug-resistant Pseudomonas aeruginosa clinical isolates in Iran. BMC Infect Dis 24:680. https:\/\/doi.org\/10.1186\/s12879-024-09585-6","journal-title":"BMC Infect Dis"},{"key":"5608_CR53","doi-asserted-by":"publisher","first-page":"991","DOI":"10.15537\/smj.2022.43.9.20220219","volume":"43","author":"P Saengsuwan","year":"2022","unstructured":"Saengsuwan P, Kositpantawong N, Kawila S et al (2022) Prevalence of carbapenemase genes among multidrug-resistant Pseudomonas aeruginosa isolates from tertiary care centers in Southern Thailand. Saudi Med J 43:991\u2013999. https:\/\/doi.org\/10.15537\/smj.2022.43.9.20220219","journal-title":"Saudi Med J"},{"issue":"13","key":"5608_CR54","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2025.1481212","volume":"25","author":"N Safdar","year":"2025","unstructured":"Safdar N, Saleem S, Salman M, Tareq AH, Ishaq S, Ambreen S, Hameed A, Habib MB, Ali TM (2025) Economic burden of antimicrobial resistance on patients in Pakistan. Front Public Health 25(13):1481212. https:\/\/doi.org\/10.3389\/fpubh.2025.1481212","journal-title":"Front Public Health"},{"key":"5608_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.genrep.2025.102184","volume":"39","author":"M Sarkheili","year":"2025","unstructured":"Sarkheili M, Asghari-Sana F, Ahmadi Asli S, Golbouy Daghdari S (2025) Biofilm formation, pigment production, and virulence gene profiles in Pseudomonas aeruginosa isolates from respiratory and urinary tract infections. Gene Rep 39:102184. https:\/\/doi.org\/10.1016\/j.genrep.2025.102184","journal-title":"Gene Rep"},{"key":"5608_CR56","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.imj.2023.05.003","volume":"2","author":"N Sathe","year":"2023","unstructured":"Sathe N, Beech P, Croft L et al (2023) Pseudomonas aeruginosa: infections and novel approaches to treatment \u201cknowing the enemy\u201d the threat of Pseudomonas aeruginosa and exploring novel approaches to treatment. Infect Med 2:178\u2013194. https:\/\/doi.org\/10.1016\/j.imj.2023.05.003","journal-title":"Infect Med"},{"key":"5608_CR57","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1080\/08927014.2018.1562549","volume":"35","author":"KB Scotland","year":"2019","unstructured":"Scotland KB, Lo J, Grgic T, Lange D (2019) Ureteral stent-associated infection and sepsis: pathogenesis and prevention: a review. Biofouling 35:117\u2013127. https:\/\/doi.org\/10.1080\/08927014.2018.1562549","journal-title":"Biofouling"},{"issue":"1","key":"5608_CR58","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-024-03318-0","volume":"24","author":"MT Shaaban","year":"2024","unstructured":"Shaaban MT, Abdel-Raouf M, Zayed M, Emara MA (2024) Microbiological and molecular studies on a multidrug-resistant Pseudomonas aeruginosa from a liver transplant patient with urinary tract infection in Egypt. BMC Microbiol 24(1):184. https:\/\/doi.org\/10.1186\/s12866-024-03318-0","journal-title":"BMC Microbiol"},{"key":"5608_CR59","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58356-1","volume":"10","author":"M Shakya","year":"2020","unstructured":"Shakya M, Ahmed SA, Davenport KW et al (2020) Standardized phylogenetic and molecular evolutionary analysis applied to species across the microbial tree of life. Sci Rep 10:1723. https:\/\/doi.org\/10.1038\/s41598-020-58356-1","journal-title":"Sci Rep"},{"key":"5608_CR60","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14040362","volume":"14","author":"SD Tesalona","year":"2025","unstructured":"Tesalona SD, Abulencia MFB, Pineda-Cortel MRB et al (2025) Identification of a potential high-risk clone and novel sequence type of carbapenem-resistant Pseudomonas aeruginosa in Metro Manila, Philippines. Antibiotics (Basel) 14:362. https:\/\/doi.org\/10.3390\/antibiotics14040362","journal-title":"Antibiotics (Basel)"},{"issue":"4","key":"5608_CR61","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlaf129","volume":"7","author":"S Tsai","year":"2025","unstructured":"Tsai S, Nigo M, Kang D et al (2025) Cefepime-zidebactam therapy for extensively drug-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae infection as a bridge to liver transplantation. JAC-Antimicrob Resist 7(4):dlaf129. https:\/\/doi.org\/10.1093\/jacamr\/dlaf129","journal-title":"JAC-Antimicrob Resist"},{"key":"5608_CR62","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12101512","volume":"12","author":"G Tulone","year":"2023","unstructured":"Tulone G, Costanzo A, Pavan N et al (2023) Analysis of bacterial stent colonization: the role of urine and device microbiological cultures. Antibiotics (Basel) 12:1512. https:\/\/doi.org\/10.3390\/antibiotics12101512","journal-title":"Antibiotics (Basel)"},{"key":"5608_CR63","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.3855\/jidc.17580","volume":"17","author":"R Ullah","year":"2023","unstructured":"Ullah R, Amir M, Anjum S et al (2023) Presence of T3SS (exoS, exoT, exoU and exoY), susceptibility pattern and MIC of MDR-Pseudomonas aeruginosa from burn wounds. J Infect Dev Ctries 17:1130\u20131137. https:\/\/doi.org\/10.3855\/jidc.17580","journal-title":"J Infect Dev Ctries"},{"key":"5608_CR64","unstructured":"World Health Organization (2017) WHO publishes list of bacteria for which new antibiotics are urgently needed. https:\/\/www.who.int\/news\/item\/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed. Accessed 25 Aug 2025"},{"key":"5608_CR65","doi-asserted-by":"publisher","DOI":"10.3390\/genes16060656","volume":"16","author":"KVM Xavier","year":"2025","unstructured":"Xavier KVM, Silva AMdeA, Luz ACdeO et al (2025) Diversity and role of prophages in Pseudomonas aeruginosa: resistance genes and bacterial interactions. Genes (Basel) 16:656. https:\/\/doi.org\/10.3390\/genes16060656","journal-title":"Genes (Basel)"},{"issue":"5","key":"5608_CR66","doi-asserted-by":"publisher","first-page":"e00118","DOI":"10.1128\/aac.00118-24","volume":"68","author":"L Xia","year":"2024","unstructured":"Xia L, Li Y, Wang Y, Zhou H, Dandekar AA, Wang M, Xu F (2024) Quorum-sensing regulation of phenazine production heightens Pseudomonas aeruginosa resistance to ciprofloxacin. Antimicrob Agents Chemother 68(5):e00118-24. https:\/\/doi.org\/10.1128\/aac.00118-24","journal-title":"Antimicrob Agents Chemother"},{"key":"5608_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.dib.2024.110344","volume":"54","author":"M Yasawong","year":"2024","unstructured":"Yasawong M, Songngamsuk T, Phatcharaharikarn M et al (2024) Draft genome sequence data of multidrug-resistant Pseudomonas aeruginosa WO7 from a hospital wastewater treatment plant in Thailand. Data Brief 54:110344. https:\/\/doi.org\/10.1016\/j.dib.2024.110344","journal-title":"Data Brief"},{"key":"5608_CR68","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.1093\/jac\/dks261","volume":"67","author":"E Zankari","year":"2012","unstructured":"Zankari E, Hasman H, Cosentino S et al (2012) Identification of acquired antimicrobial resistance genes. J Antimicrob Chemother 67:2640\u20132644. https:\/\/doi.org\/10.1093\/jac\/dks261","journal-title":"J Antimicrob Chemother"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05608-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05608-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05608-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:14:53Z","timestamp":1789978493000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05608-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,28]]},"references-count":68,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["5608"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05608-y","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,28]]},"assertion":[{"value":"1 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethical approval was taken from Bio-Ethical Committee (BEC) of Quaid Azam University (BEC-FBS-QAU2022-398). The study was conducted according to Declaration of Helsinki. Informed consent was taken from all the patients who participated in the study. All samples were coded prior to microbiological analysis to ensure confidentiality.","order":1,"name":"Ethics","label":"<b>Ethical approval and consent to participate<\/b>","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}