{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T23:35:54Z","timestamp":1792884954220,"version":"4.5.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"13","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s00210-026-05677-z","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:14:25Z","timestamp":1783138465000},"page":"20465-20476","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rosmarinic acid inhibits norepinephrine-induced metastatic capacity of triple negative breast cancer cells by Src kinase inactivation"],"prefix":"10.1007","volume":"399","author":[{"given":"Jae-Hoon","family":"Jeong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Ji","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Hyung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"key":"5677_CR1","doi-asserted-by":"publisher","first-page":"12909","DOI":"10.3390\/ijms252312909","volume":"25","author":"M Ahmadi","year":"2024","unstructured":"Ahmadi M, Kim HL, Park SJ, Jung HJ (2024) Echium amoenum and rosmarinic acid suppress the growth and metastasis of gastric cancer AGS cells by promoting apoptosis and inhibiting EMT. Int J Mol Sci 25:12909. https:\/\/doi.org\/10.3390\/ijms252312909","journal-title":"Int J Mol Sci"},{"key":"5677_CR2","doi-asserted-by":"publisher","first-page":"10300","DOI":"10.1038\/s41598-020-65648-z","volume":"10","author":"S Anwar","year":"2020","unstructured":"Anwar S, Shamsi A, Shahbaaz M, Queen A, Khan P, Hasan GM, Islam A, Alajmi MF, Hussain A, Ahmad F, Hassan MI (2020) Rosmarinic acid exhibits anticancer effects via MARK4 inhibition. Sci Rep 10:10300. https:\/\/doi.org\/10.1038\/s41598-020-65648-z","journal-title":"Sci Rep"},{"key":"5677_CR3","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1038\/ncomms2413","volume":"4","author":"GN Armaiz-Pena","year":"2013","unstructured":"Armaiz-Pena GN, Allen JK, Cruz A, Stone RL, Nick AM, Lin YG, Han LY, Mangala LS, Villares GJ, Vivas-Mejia P, Rodriguez-Aguayo C, Nagaraja AS, Gharpure KM, Wu Z, English RD, Soman KV, Shahzad MM, Zigler M, Deavers MT, Zien A, Soldatos TG, Jackson DB, Wiktorowicz JE, Torres-Lugo M, Young T, De Geest K, Gallick GE, Bar-Eli M, Lopez-Berestein G, Cole SW, Lopez GE, Lutgendorf SK, Sood AK (2013) Src activation by \u03b2-adrenoreceptors is a key switch for tumour metastasis. Nat Commun 4:1403. https:\/\/doi.org\/10.1038\/ncomms2413","journal-title":"Nat Commun"},{"key":"5677_CR4","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.breast.2022.08.010","volume":"66","author":"M Arnold","year":"2022","unstructured":"Arnold M, Morgan E, Rumgay H, Mafra A, Singh D, Laversanne M, Vignat J, Gralow JR, Cardoso F, Siesling S, Soerjomataram I (2022) Current and future burden of breast cancer: global statistics for 2020 and 2040. Breast 66:15\u201323. https:\/\/doi.org\/10.1016\/j.breast.2022.08.010","journal-title":"Breast"},{"key":"5677_CR5","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1200\/JCO.2010.33.5422","volume":"29","author":"TI Barron","year":"2011","unstructured":"Barron TI, Connolly RM, Sharp L, Bennett K, Visvanathan K (2011) Beta blockers and breast cancer mortality: a population-based study. J Clin Oncol 29:2635\u20132644. https:\/\/doi.org\/10.1200\/JCO.2010.33.5422","journal-title":"J Clin Oncol"},{"key":"5677_CR6","doi-asserted-by":"publisher","first-page":"676731","DOI":"10.1155\/2012\/676731","volume":"2012","author":"G Bendas","year":"2012","unstructured":"Bendas G, Borsig L (2012) Cancer cell adhesion and metastasis: selectins, integrins, and the inhibitory potential of heparins. Int J Cell Biol 2012:676731. https:\/\/doi.org\/10.1155\/2012\/676731","journal-title":"Int J Cell Biol"},{"key":"5677_CR7","doi-asserted-by":"publisher","first-page":"3135","DOI":"10.3892\/or.2016.4710","volume":"35","author":"C Choy","year":"2016","unstructured":"Choy C, Raytis JL, Smith DD, Duenas M, Neman J, Jandial R, Lew MW (2016) Inhibition of \u03b22-adrenergic receptor reduces triple-negative breast cancer brain metastases: the potential benefit of perioperative \u03b2-blockade. Oncol Rep 35:3135\u20133142. https:\/\/doi.org\/10.3892\/or.2016.4710","journal-title":"Oncol Rep"},{"key":"5677_CR8","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1158\/1078-0432.CCR-11-0641","volume":"18","author":"SW Cole","year":"2012","unstructured":"Cole SW, Sood AK (2012) Molecular pathways: beta-adrenergic signaling in cancer. Clin Cancer Res 18:1201\u20131206. https:\/\/doi.org\/10.1158\/1078-0432.CCR-11-0641","journal-title":"Clin Cancer Res"},{"key":"5677_CR9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41413-021-00137-1","volume":"9","author":"F Concei\u00e7\u00e3o","year":"2021","unstructured":"Concei\u00e7\u00e3o F, Sousa DM, Paredes J, Lamghari M (2021) Sympathetic activity in breast cancer and metastasis: partners in crime. Bone Res 9:9. https:\/\/doi.org\/10.1038\/s41413-021-00137-1","journal-title":"Bone Res"},{"key":"5677_CR10","doi-asserted-by":"publisher","first-page":"106421","DOI":"10.1016\/j.phrs.2022.106421","volume":"184","author":"A Dahchour","year":"2022","unstructured":"Dahchour A (2022) Anxiolytic and antidepressive potentials of rosmarinic acid: a review with a focus on antioxidant and anti-inflammatory effects. Pharmacol Res 184:106421. https:\/\/doi.org\/10.1016\/j.phrs.2022.106421","journal-title":"Pharmacol Res"},{"key":"5677_CR11","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1093\/jb\/mvi018","volume":"137","author":"M Funakoshi-Tago","year":"2005","unstructured":"Funakoshi-Tago M, Tago K, Andoh K, Sonoda Y, Tominaga S, Kasahara T (2005) Functional role of c-Src in IL-1-induced NF-kappa B activation: c-Src is a component of the IKK complex. J Biochem 137:189\u2013197. https:\/\/doi.org\/10.1093\/jb\/mvi018","journal-title":"J Biochem"},{"key":"5677_CR12","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s10549-011-1505-3","volume":"129","author":"PA Ganz","year":"2011","unstructured":"Ganz PA, Habel LA, Weltzien EK, Caan BJ, Cole SW (2011) Examining the influence of beta blockers and ACE inhibitors on the risk for breast cancer recurrence: results from the LACE cohort. Breast Cancer Res Treat 129:549\u2013556. https:\/\/doi.org\/10.1007\/s10549-011-1505-3","journal-title":"Breast Cancer Res Treat"},{"key":"5677_CR13","doi-asserted-by":"publisher","first-page":"3292","DOI":"10.3390\/molecules27103292","volume":"27","author":"H Guan","year":"2022","unstructured":"Guan H, Luo W, Bao B, Cao Y, Cheng F, Yu S, Fan Q, Zhang L, Wu Q, Shan M (2022) A comprehensive review of rosmarinic acid: from phytochemistry to pharmacology and its new insight. Molecules 27:3292. https:\/\/doi.org\/10.3390\/molecules27103292","journal-title":"Molecules"},{"key":"5677_CR14","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3389\/fphar.2018.00068","volume":"9","author":"YH Han","year":"2018","unstructured":"Han YH, Kee JY, Hong SH (2018) Rosmarinic acid activates AMPK to inhibit metastasis of colorectal cancer. Front Pharmacol 9:68. https:\/\/doi.org\/10.3389\/fphar.2018.00068","journal-title":"Front Pharmacol"},{"key":"5677_CR15","doi-asserted-by":"publisher","first-page":"108878","DOI":"10.1016\/j.biopha.2019.108878","volume":"115","author":"Y Han","year":"2019","unstructured":"Han Y, Ma L, Zhao L, Feng W, Zheng X (2019) Rosmarinic inhibits cell proliferation, invasion and migration via up-regulating miR-506 and suppressing MMP2\/16 expression in pancreatic cancer. Biomed Pharmacother 115:108878. https:\/\/doi.org\/10.1016\/j.biopha.2019.108878","journal-title":"Biomed Pharmacother"},{"key":"5677_CR16","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1016\/S0140-6736(16)31891-8","volume":"389","author":"N Harbeck","year":"2017","unstructured":"Harbeck N, Gnant M (2017) Breast cancer. Lancet 389:1134\u20131150. https:\/\/doi.org\/10.1016\/S0140-6736(16)31891-8","journal-title":"Lancet"},{"key":"5677_CR17","first-page":"57","volume":"3","author":"S Hossan","year":"2014","unstructured":"Hossan S, Rahman S, Jahan R, Al-Nahain A, Rahmatullah M (2014) Rosmarinic acid: a review of its anticancer action. World J Pharm Pharm Sci 3:57\u201370","journal-title":"World J Pharm Pharm Sci"},{"key":"5677_CR18","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.ccr.2004.09.001","volume":"6","author":"R Ishizawar","year":"2004","unstructured":"Ishizawar R, Parsons SJ (2004) c-Src and cooperating partners in human cancer. Cancer Cell 6:209\u2013214. https:\/\/doi.org\/10.1016\/j.ccr.2004.09.001","journal-title":"Cancer Cell"},{"key":"5677_CR19","doi-asserted-by":"publisher","first-page":"5940","DOI":"10.3390\/molecules27185940","volume":"27","author":"JH Jeong","year":"2022","unstructured":"Jeong JH, Park HJ, Park SH, Choi YH, Chi GY (2022) \u03b22-Adrenergic receptor signaling pathway stimulates the migration and invasion of cancer cells via Src activation. Molecules 27:5940. https:\/\/doi.org\/10.3390\/molecules27185940","journal-title":"Molecules"},{"key":"5677_CR20","doi-asserted-by":"publisher","first-page":"3414","DOI":"10.3390\/molecules28083414","volume":"28","author":"JH Jeong","year":"2023","unstructured":"Jeong JH, Park HJ, Chi GY, Choi YH, Park SH (2023) An ethanol extract of Perilla frutescens leaves suppresses adrenergic agonist-induced metastatic ability of cancer cells by inhibiting Src-mediated EMT. Molecules 28:3414. https:\/\/doi.org\/10.3390\/molecules28083414","journal-title":"Molecules"},{"key":"5677_CR21","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/nrclinonc.2018.8","volume":"15","author":"DE Johnson","year":"2018","unstructured":"Johnson DE, O\u2019Keefe RA, Grandis JR (2018) Targeting the IL-6\/JAK\/STAT3 signalling axis in cancer. Nat Rev Clin Oncol 15:234\u2013248. https:\/\/doi.org\/10.1038\/nrclinonc.2018.8","journal-title":"Nat Rev Clin Oncol"},{"key":"5677_CR22","doi-asserted-by":"publisher","first-page":"7353","DOI":"10.1073\/pnas.1812876116","volume":"116","author":"C Kr\u00f6ger","year":"2019","unstructured":"Kr\u00f6ger C, Afeyan A, Mraz J, Eaton EN, Reinhardt F, Khodor YL, Thiru P, Bierie B, Ye X, Burge CB, Weinberg RA (2019) Acquisition of a hybrid E\/M state is essential for tumorigenicity of basal breast cancer cells. Proc Natl Acad Sci U S A 116:7353\u20137362. https:\/\/doi.org\/10.1073\/pnas.1812876116","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5677_CR23","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s13045-018-0623-3","volume":"11","author":"L Lang","year":"2018","unstructured":"Lang L, Shay C, Xiong Y, Thakkar P, Chemmalakuzhy R, Wang X, Teng Y (2018) Combating head and neck cancer metastases by targeting Src using multifunctional nanoparticle-based saracatinib. J Hematol Oncol 11:85. https:\/\/doi.org\/10.1186\/s13045-018-0623-3","journal-title":"J Hematol Oncol"},{"key":"5677_CR24","doi-asserted-by":"publisher","first-page":"623","DOI":"10.3390\/cells9030623","volume":"9","author":"TT Liao","year":"2020","unstructured":"Liao TT, Yang MH (2020) Hybrid epithelial\/mesenchymal state in cancer metastasis: clinical significance and regulatory mechanisms. Cells 9:623. https:\/\/doi.org\/10.3390\/cells9030623","journal-title":"Cells"},{"key":"5677_CR25","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1093\/aje\/kwg002","volume":"157","author":"K Lillberg","year":"2003","unstructured":"Lillberg K, Verkasalo PK, Kaprio J, Teppo L, Helenius H, Koskenvuo M (2003) Stressful life events and risk of breast cancer in 10,808 women: a cohort study. Am J Epidemiol 157:415\u2013423. https:\/\/doi.org\/10.1093\/aje\/kwg002","journal-title":"Am J Epidemiol"},{"key":"5677_CR26","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1093\/abbs\/gmq043","volume":"42","author":"X Liu","year":"2010","unstructured":"Liu X, Feng R (2010) Inhibition of epithelial to mesenchymal transition in metastatic breast carcinoma cells by c-Src suppression. Acta Biochim Biophys Sin (Shanghai) 42:496\u2013501. https:\/\/doi.org\/10.1093\/abbs\/gmq043","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"5677_CR27","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.3390\/medicina61061008","volume":"61","author":"MD Meoded","year":"2025","unstructured":"Meoded MD, T\u0103nase M, Mehedin\u021bu C, Cirimbei C (2025) Psycho-oncology in breast cancer: supporting women through distress, treatment, and recovery\u2014three arguments\u2014rapid narrative review. Medicina (Kaunas) 61:1008. https:\/\/doi.org\/10.3390\/medicina61061008","journal-title":"Medicina (Kaunas)"},{"key":"5677_CR28","doi-asserted-by":"publisher","first-page":"173419","DOI":"10.1016\/j.ejphar.2020.173419","volume":"885","author":"SS Messeha","year":"2020","unstructured":"Messeha SS, Zarmouh NO, Asiri A, Soliman KFA (2020) Rosmarinic acid-induced apoptosis and cell cycle arrest in triple-negative breast cancer cells. Eur J Pharmacol 885:173419. https:\/\/doi.org\/10.1016\/j.ejphar.2020.173419","journal-title":"Eur J Pharmacol"},{"key":"5677_CR29","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.3390\/cells13201674","volume":"13","author":"W Parichatikanond","year":"2024","unstructured":"Parichatikanond W, Duangrat R, Kurose H, Mangmool S (2024) Regulation of \u03b2-adrenergic receptors in the heart: a review on emerging therapeutic strategies for heart failure. Cells 13:1674. https:\/\/doi.org\/10.3390\/cells13201674","journal-title":"Cells"},{"key":"5677_CR30","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1002\/1097-0142(20010215)91:4<686::AID-CNCR1052>3.0.CO;2-0","volume":"91","author":"MA Price","year":"2001","unstructured":"Price MA, Tennant CC, Butow PN, Smith CA, Kenneally A, Kossoff MB (2001) The role of psychosocial factors in the development of breast carcinoma. Part I: the relationship between life events and breast cancer. Cancer 91:686\u2013697. https:\/\/doi.org\/10.1002\/1097-0142(20010215)91:4%3c686::AID-CNCR1052%3e3.0.CO;2-0","journal-title":"Cancer"},{"key":"5677_CR31","doi-asserted-by":"publisher","first-page":"10761","DOI":"10.3390\/ijms140610761","volume":"14","author":"K Sato","year":"2013","unstructured":"Sato K (2013) Cellular functions regulated by phosphorylation of EGFR on Tyr845. Int J Mol Sci 14:10761\u201310790. https:\/\/doi.org\/10.3390\/ijms140610761","journal-title":"Int J Mol Sci"},{"key":"5677_CR32","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3322\/caac.21871","volume":"75","author":"RL Siegel","year":"2025","unstructured":"Siegel RL, Kratzer TB, Giaquinto AN, Sung H, Jemal A (2025) Cancer statistics, 2025. CA Cancer J Clin 75:10\u201345. https:\/\/doi.org\/10.3322\/caac.21871","journal-title":"CA Cancer J Clin"},{"key":"5677_CR33","doi-asserted-by":"publisher","first-page":"3917","DOI":"10.1158\/1078-0432.CCR-17-3775","volume":"24","author":"K Srivastava","year":"2018","unstructured":"Srivastava K, Pickard A, Craig SG, Quinn GP, Lambe SM, James JA, McDade SS, McCance DJ (2018) \u0394Np63\u03b3\/SRC\/Slug signaling axis promotes epithelial-to-mesenchymal transition in squamous cancers. Clin Cancer Res 24:3917\u20133927. https:\/\/doi.org\/10.1158\/1078-0432.CCR-17-3775","journal-title":"Clin Cancer Res"},{"key":"5677_CR34","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1073\/pnas.96.4.1415","volume":"96","author":"DA Tice","year":"1999","unstructured":"Tice DA, Biscardi JS, Nickles AL, Parsons SJ (1999) Mechanism of biological synergy between cellular Src and epidermal growth factor receptor. Proc Natl Acad Sci U S A 96:1415\u20131420. https:\/\/doi.org\/10.1073\/pnas.96.4.1415","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5677_CR35","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3390\/ijms17010095","volume":"17","author":"Z Wang","year":"2016","unstructured":"Wang Z (2016) Transactivation of epidermal growth factor receptor by G protein-coupled receptors: recent progress, challenges and future research. Int J Mol Sci 17:95. https:\/\/doi.org\/10.3390\/ijms17010095","journal-title":"Int J Mol Sci"},{"key":"5677_CR36","doi-asserted-by":"publisher","first-page":"345","DOI":"10.21037\/apm-25-30","volume":"14","author":"B Wang","year":"2025","unstructured":"Wang B, He X, Dutta S, Chen S, Liang J, Huang W, Ahmad W, Xu M, Wang Y (2025) New progress and challenges of targeted therapies for breast cancer. Ann Palliat Med 14:345\u2013352. https:\/\/doi.org\/10.21037\/apm-25-30","journal-title":"Ann Palliat Med"},{"key":"5677_CR38","doi-asserted-by":"publisher","first-page":"10461","DOI":"10.1007\/s00210-025-03927-0","volume":"398","author":"C Xie","year":"2025","unstructured":"Xie C, Chan L, Pang Y, Shang Y, Wang W, Zhao L (2025) Rosmarinic acid promotes mitochondrial fission and induces ferroptosis in triple-negative breast cancer cells. Naunyn Schmiedebergs Arch Pharmacol 398:10461\u201310475. https:\/\/doi.org\/10.1007\/s00210-025-03927-0","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"5677_CR39","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1007\/s11130-010-0166-4","volume":"65","author":"O Yesil-Celiktas","year":"2010","unstructured":"Yesil-Celiktas O, Sevimli C, Bedir E, Vardar-Sukan F (2010) Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines. Plant Foods Hum Nutr 65:158\u2013163. https:\/\/doi.org\/10.1007\/s11130-010-0166-4","journal-title":"Plant Foods Hum Nutr"},{"key":"5677_CR40","doi-asserted-by":"publisher","first-page":"116609","DOI":"10.1016\/j.biopha.2024.116609","volume":"175","author":"H Zhang","year":"2024","unstructured":"Zhang H, Yang Y, Cao Y, Guan J (2024) Effects of chronic stress on cancer development and the therapeutic prospects of adrenergic signaling regulation. Biomed Pharmacother 175:116609. https:\/\/doi.org\/10.1016\/j.biopha.2024.116609","journal-title":"Biomed Pharmacother"},{"key":"5677_CR41","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.jncc.2025.02.002","volume":"5","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, Ji Y, Liu S, Li J, Wu J, Jin Q, Liu X, Duan H, Feng Z, Liu Y, Zhang Y, Lyu Z, Song F, Song F, Yang L, Liu H, Huang Y (2025) Global burden of female breast cancer: new estimates in 2022, temporal trend and future projections up to 2050 based on the latest release from GLOBOCAN. J Natl Cancer Cent 5:287\u2013296. https:\/\/doi.org\/10.1016\/j.jncc.2025.02.002","journal-title":"J Natl Cancer Cent"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05677-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05677-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05677-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T23:03:05Z","timestamp":1792882985000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05677-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,4]]},"references-count":40,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["5677"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05677-z","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,4]]},"assertion":[{"value":"2 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}