{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:48:13Z","timestamp":1785523693612,"version":"3.56.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"DOI":"10.1007\/s00210-026-05713-y","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T06:16:33Z","timestamp":1785219393000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-omics Mendelian randomization identified adaptive immune response\u2013related drug targets in psoriatic arthritis"],"prefix":"10.1007","author":[{"given":"Zhaopeng","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lintao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"5713_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054901","author":"AB Azuaga","year":"2023","unstructured":"Azuaga AB, Ram\u00edrez J, Ca\u00f1ete JD (2023) Psoriatic arthritis: pathogenesis and targeted therapies. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms24054901","journal-title":"Int J Mol Sci"},{"issue":"2","key":"5713_CR2","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/dyv080","volume":"44","author":"J Bowden","year":"2015","unstructured":"Bowden J, Davey Smith G, Burgess S (2015) Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol 44(2):512\u2013525","journal-title":"Int J Epidemiol"},{"issue":"7","key":"5713_CR3","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s10654-015-0011-z","volume":"30","author":"S Burgess","year":"2015","unstructured":"Burgess S, Scott RA, Timpson NJ, Davey Smith G, Thompson SG (2015) Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors. Eur J Epidemiol 30(7):543\u2013552","journal-title":"Eur J Epidemiol"},{"key":"5713_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04474-z","author":"Y Cao","year":"2023","unstructured":"Cao Y, Yang Y, Hu Q, Wei G (2023) Identification of potential drug targets for rheumatoid arthritis from genetic insights: a Mendelian randomization study. J Transl Med. https:\/\/doi.org\/10.1186\/s12967-023-04474-z","journal-title":"J Transl Med"},{"key":"5713_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104199","author":"Y Chen","year":"2022","unstructured":"Chen Y, Xu X, Wang L, Li K, Sun Y, Xiao L et al (2022) Genetic insights into therapeutic targets for aortic aneurysms: a Mendelian randomization study. EBioMedicine. https:\/\/doi.org\/10.1016\/j.ebiom.2022.104199","journal-title":"EBioMedicine"},{"issue":"R1","key":"5713_CR6","doi-asserted-by":"publisher","first-page":"R89","DOI":"10.1093\/hmg\/ddu328","volume":"23","author":"G Davey Smith","year":"2014","unstructured":"Davey Smith G, Hemani G (2014) Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet 23(R1):R89\u2013R98","journal-title":"Hum Mol Genet"},{"key":"5713_CR7","doi-asserted-by":"publisher","unstructured":"Ding Q, Xu Q, Hong Y, Zhou H, He X, Niu C et al (2024) Integrated analysis of single-cell RNA-seq, bulk RNA-seq, Mendelian randomization, andeQTL reveals T cell-related nomogram model and subtype classification in rheumatoid arthritis. Front Immunol 15:1399856. https:\/\/doi.org\/10.3389\/fimmu.2024.1399856","DOI":"10.3389\/fimmu.2024.1399856"},{"key":"5713_CR8","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a040980","author":"BA Ference","year":"2021","unstructured":"Ference BA, Holmes MV, Smith GD (2021) Using Mendelian randomization to improve the design of randomized trials. Cold Spring Harb Perspect Med. https:\/\/doi.org\/10.1101\/cshperspect.a040980","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"12","key":"5713_CR9","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1038\/s41588-021-00978-w","volume":"53","author":"E Ferkingstad","year":"2021","unstructured":"Ferkingstad E, Sulem P, Atlason BA, Sveinbjornsson G, Magnusson MI, Styrmisdottir EL et al (2021) Large-scale integration of the plasma proteome with genetics and disease. Nat Genet 53(12):1712\u20131721","journal-title":"Nat Genet"},{"key":"5713_CR10","doi-asserted-by":"publisher","unstructured":"Finan C, Gaulton A, Kruger FA, Lumbers RT, Shah T, Engmann J et al (2017) The druggable genome and support for target identifi cation andvalidation in drug development. Sci Transl Med. https:\/\/doi.org\/10.1126\/scitranslmed.aag1166","DOI":"10.1126\/scitranslmed.aag1166"},{"issue":"6","key":"5713_CR11","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/s41588-020-0622-5","volume":"52","author":"SA Gagliano Taliun","year":"2020","unstructured":"Gagliano Taliun SA, VandeHaar P, Boughton AP, Welch RP, Taliun D, Schmidt EM et al (2020) Exploring and visualizing large-scale genetic associations by using PheWeb. Nat Genet 52(6):550\u2013552","journal-title":"Nat Genet"},{"key":"5713_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1448308","volume":"15","author":"J Gao","year":"2024","unstructured":"Gao J, Yuan L, Jiang H, Li G, Zhang Y, Zhou R et al (2024) Naringenin modulates oxidative stress and lipid metabolism: insights from network pharmacology, mendelian randomization, and molecular docking. Front Pharmacol 15","journal-title":"Front Pharmacol"},{"key":"5713_CR13","doi-asserted-by":"publisher","unstructured":"Giambartolomei C, Vukcevic D, Schadt EE, Franke L, Hingorani AD, Wallace C et al (2014) Bayesian test for colocalisation between pairs of geneticassociation studies using summary statistics. PLoS Genet 10(5):e1004383. https:\/\/doi.org\/10.1371\/journal.pgen.1004383","DOI":"10.1371\/journal.pgen.1004383"},{"issue":"1","key":"5713_CR14","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.jaad.2020.05.089","volume":"84","author":"AB Gottlieb","year":"2021","unstructured":"Gottlieb AB, Merola JF (2021) Axial psoriatic arthritis: an update for dermatologists. J Am Acad Dermatol 84(1):92\u2013101","journal-title":"J Am Acad Dermatol"},{"issue":"21","key":"5713_CR15","doi-asserted-by":"publisher","first-page":"2926","DOI":"10.1002\/sim.6522","volume":"34","author":"MFD Greco","year":"2015","unstructured":"Greco MFD, Minelli C, Sheehan NA, Thompson JR (2015) Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome. Stat Med 34(21):2926\u20132940","journal-title":"Stat Med"},{"key":"5713_CR16","doi-asserted-by":"publisher","unstructured":"Harbour SN, DiToro DF, Witte SJ, Zindl CL, Gao M, Schoeb TR et al (2020) TH17 cells require ongoing classic IL-6 receptor signaling to retaintranscriptional and functional identity. Sci Immunol 5(49):eaaw2262. https:\/\/doi.org\/10.1126\/sciimmunol.aaw2262","DOI":"10.1126\/sciimmunol.aaw2262"},{"issue":"6","key":"5713_CR17","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1093\/ije\/dyx102","volume":"46","author":"FP Hartwig","year":"2017","unstructured":"Hartwig FP, Davey Smith G, Bowden J (2017) Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption. Int J Epidemiol 46(6):1985\u20131998","journal-title":"Int J Epidemiol"},{"key":"5713_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1215-1","author":"Y Hasin","year":"2017","unstructured":"Hasin Y, Seldin M, Lusis A (2017) Multi-omics approaches to disease. Genome Biol. https:\/\/doi.org\/10.1186\/s13059-017-1215-1","journal-title":"Genome Biol"},{"issue":"R2","key":"5713_CR19","doi-asserted-by":"publisher","first-page":"R195","DOI":"10.1093\/hmg\/ddy163","volume":"27","author":"G Hemani","year":"2018","unstructured":"Hemani G, Bowden J, Davey Smith G (2018) Evaluating the potential role of pleiotropy in Mendelian randomization studies. Hum Mol Genet 27(R2):R195\u2013R208","journal-title":"Hum Mol Genet"},{"key":"5713_CR20","doi-asserted-by":"publisher","unstructured":"Huynh D, Kavanaugh A (2014) (2015) Psoriatic arthritis: current therapy and future approaches. Rheumatology 54(1):20\u201328. https:\/\/doi.org\/10.1093\/rheumatology\/keu237","DOI":"10.1093\/rheumatology\/keu237"},{"issue":"12","key":"5713_CR21","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41577-018-0066-7","volume":"18","author":"SA Jones","year":"2018","unstructured":"Jones SA, Jenkins BJ (2018) Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer. Nat Rev Immunol 18(12):773\u2013789","journal-title":"Nat Rev Immunol"},{"key":"5713_CR22","doi-asserted-by":"publisher","unstructured":"Kim M, Kim C, Zheng H, Kim Y, Cho PS, Lim JY et al (2024) Pharmacologic inhibition of Il6st\/gp130 improves dermatological infl ammation andpruritus. Biomed Pharmacother 178:117155. https:\/\/doi.org\/10.1016\/j.biopha.2024.117155","DOI":"10.1016\/j.biopha.2024.117155"},{"issue":"1","key":"5713_CR23","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.tig.2022.08.005","volume":"39","author":"P Kreitmaier","year":"2023","unstructured":"Kreitmaier P, Katsoula G, Zeggini E (2023) Insights from multi-omics integration in complex disease primary tissues. Trends Genet 39(1):46\u201358","journal-title":"Trends Genet"},{"issue":"W1","key":"5713_CR24","doi-asserted-by":"publisher","first-page":"W90","DOI":"10.1093\/nar\/gkw377","volume":"44","author":"MV Kuleshov","year":"2016","unstructured":"Kuleshov MV, Jones MR, Rouillard AD, Fernandez NF, Duan Q, Wang Z et al (2016) Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res 44(W1):W90\u2013W97","journal-title":"Nucleic Acids Res"},{"key":"5713_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241411662","author":"B-W Lee","year":"2023","unstructured":"Lee B-W, Moon S-J (2023) Inflammatory cytokines in psoriatic arthritis: understanding pathogenesis and implications for treatment. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms241411662","journal-title":"Int J Mol Sci"},{"issue":"2","key":"5713_CR26","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1097\/BOR.0000000000000255","volume":"28","author":"X Liu","year":"2016","unstructured":"Liu X, Jones GW, Choy EH, Jones SA (2016) The biology behind interleukin-6 targeted interventions. Curr Opin Rheumatol 28(2):152\u2013160","journal-title":"Curr Opin Rheumatol"},{"issue":"3","key":"5713_CR27","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1136\/annrheumdis-2020-218481","volume":"80","author":"E L\u00f3pez-Isac","year":"2021","unstructured":"L\u00f3pez-Isac E, Smith SL, Marion MC, Wood A, Sudman M, Yarwood A et al (2021) Combined genetic analysis of juvenile idiopathic arthritis clinical subtypes identifies novel risk loci, target genes and key regulatory mechanisms. Ann Rheum Dis 80(3):321\u20138","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"5713_CR28","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1007\/s40744-020-00229-0","volume":"7","author":"E Lubrano","year":"2020","unstructured":"Lubrano E, Scriffignano S, Azuaga AB, Ramirez J, Canete JD, Perrotta FM (2020) Impact of comorbidities on disease activity, patient global assessment, and function in psoriatic arthritis: a cross-sectional study. Rheumatol Ther 7(4):825\u201336","journal-title":"Rheumatol Ther"},{"issue":"2","key":"5713_CR29","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1158\/1535-7163.MCT-17-1079","volume":"18","author":"DT Martin","year":"2019","unstructured":"Martin DT, Shen H, Steinbach-Rankins JM, Zhu X, Johnson KK, Syed J et al (2019) Glycoprotein-130 expression is associated with aggressive bladder cancer and is a potential therapeutic target. Mol Cancer Ther 18(2):413\u2013420","journal-title":"Mol Cancer Ther"},{"key":"5713_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11070618","author":"C Mart\u00ednez-P\u00e9rez","year":"2021","unstructured":"Mart\u00ednez-P\u00e9rez C, Leung J, Kay C, Meehan J, Gray M, Dixon JM et al (2021) The signal transducer IL6ST (gp130) as a predictive and prognostic biomarker in breast cancer. J Pers Med. https:\/\/doi.org\/10.3390\/jpm11070618","journal-title":"J Pers Med"},{"issue":"4","key":"5713_CR31","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.rdc.2015.07.001","volume":"41","author":"A Ogdie","year":"2015","unstructured":"Ogdie A, Weiss P (2015) The epidemiology of psoriatic arthritis. Rheum Dis Clin North Am 41(4):545\u2013568","journal-title":"Rheum Dis Clin North Am"},{"issue":"Suppl 1","key":"5713_CR32","doi-asserted-by":"publisher","first-page":"i37","DOI":"10.1093\/rheumatology\/kez383","volume":"59","author":"A Ogdie","year":"2020","unstructured":"Ogdie A, Coates LC, Gladman DD (2020) Treatment guidelines in psoriatic arthritis. Rheumatology (Oxford) 59(Suppl 1):i37\u2013i46","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"5713_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34173-5","volume":"8","author":"T Oike","year":"2018","unstructured":"Oike T, Kanagawa H, Sato Y, Kobayashi T, Nakatsukasa H, Miyamoto K et al (2018) IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse. Sci Rep 8(1)","journal-title":"Sci Rep"},{"key":"5713_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2023.156446","author":"S Pan","year":"2024","unstructured":"Pan S, Wu S, Wei Y, Liu J, Zhou C, Chen T et al (2024) Exploring the causal relationship between inflammatory cytokines and inflammatory arthritis: a Mendelian randomization study. Cytokine. https:\/\/doi.org\/10.1016\/j.cyto.2023.156446","journal-title":"Cytokine"},{"issue":"1","key":"5713_CR35","doi-asserted-by":"publisher","first-page":"4767","DOI":"10.1038\/s41467-020-18513-6","volume":"11","author":"F Penkava","year":"2020","unstructured":"Penkava F, Velasco-Herrera MDC, Young MD, Yager N, Nwosu LN, Pratt AG et al (2020) Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis. Nat Commun 11(1):4767","journal-title":"Nat Commun"},{"key":"5713_CR36","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a038984","author":"E Sanderson","year":"2021","unstructured":"Sanderson E (2021) Multivariable Mendelian randomization and mediation. Cold Spring Harb Perspect Med. https:\/\/doi.org\/10.1101\/cshperspect.a038984","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"6","key":"5713_CR37","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1084\/jem.20052187","volume":"203","author":"S-i Sawa","year":"2006","unstructured":"Sawa S-i, Kamimura D, Jin G-H, Morikawa H, Kamon H, Nishihara M et al (2006) Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3\/IL-7\u2013dependent homeostatic proliferation of CD4+ T cells. J Exp Med 203(6):1459\u20131470","journal-title":"J Exp Med"},{"issue":"3","key":"5713_CR38","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/s41584-019-0175-0","volume":"15","author":"JU Scher","year":"2019","unstructured":"Scher JU, Ogdie A, Merola JF, Ritchlin C (2019) Preventing psoriatic arthritis: focusing on patients with psoriasis at increased risk of transition. Nat Rev Rheumatol 15(3):153\u2013166","journal-title":"Nat Rev Rheumatol"},{"issue":"9","key":"5713_CR39","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1002\/art.42154","volume":"74","author":"M Soomro","year":"2022","unstructured":"Soomro M, Stadler M, Dand N, Bluett J, Jadon D, Jalali-Najafabadi F et al (2022) Comparative genetic analysis of psoriatic arthritis and psoriasis for the discovery of genetic risk factors and risk prediction modeling. Arthritis Rheumatol 74(9):1535\u20131543","journal-title":"Arthritis Rheumatol"},{"issue":"7982","key":"5713_CR40","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41586-023-06592-6","volume":"622","author":"BB Sun","year":"2023","unstructured":"Sun BB, Chiou J, Traylor M, Benner C, Hsu Y-H, Richardson TG et al (2023) Plasma proteomic associations with genetics and health in the UK Biobank. Nature 622(7982):329\u2013338","journal-title":"Nature"},{"key":"5713_CR41","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-024-01828-w","author":"X Sun","year":"2024","unstructured":"Sun X, Chen B, Qi Y, Wei M, Chen W, Wu X et al (2024) Multi-omics Mendelian randomization integrating GWAS, eQTL and pQTL data revealed GSTM4 as a potential drug target for migraine. J Headache Pain. https:\/\/doi.org\/10.1186\/s10194-024-01828-w","journal-title":"J Headache Pain"},{"issue":"4-5","key":"5713_CR42","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.autrev.2014.01.050","volume":"13","author":"E Suzuki","year":"2014","unstructured":"Suzuki E, Mellins ED, Gershwin ME, Nestle FO, Adamopoulos IE (2014) The IL-23\/IL-17 axis in psoriatic arthritis. Autoimmun Rev 13(4\u20135):496\u2013502","journal-title":"Autoimmun Rev"},{"issue":"D1","key":"5713_CR43","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif M et al (2023) The STRING database in 2023: protein\u2013protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res 51(D1):D638\u2013D646","journal-title":"Nucleic Acids Res"},{"key":"5713_CR44","doi-asserted-by":"crossref","unstructured":"Tanaka T, Narazaki M, Kishimoto T (2014) IL-6 in inflammation, immunity, and disease. Cold Spring Harbor Perspect Biol 6(10):a016295-a","DOI":"10.1101\/cshperspect.a016295"},{"issue":"10136","key":"5713_CR45","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1016\/S0140-6736(18)30830-4","volume":"391","author":"DJ Veale","year":"2018","unstructured":"Veale DJ, Fearon U (2018) The pathogenesis of psoriatic arthritis. Lancet 391(10136):2273\u20132284","journal-title":"Lancet"},{"key":"5713_CR46","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.596086","volume":"11","author":"M Vecellio","year":"2020","unstructured":"Vecellio M, Hake VX, Davidson C, Carena MC, Wordsworth BP, Selmi C (2020) The IL-17\/IL-23 axis and its genetic contribution to psoriatic arthritis. Front Immunol 11","journal-title":"Front Immunol"},{"issue":"6","key":"5713_CR47","doi-asserted-by":"publisher","first-page":"627","DOI":"10.2340\/00015555-1833","volume":"94","author":"K Vlam","year":"2014","unstructured":"Vlam K, Gottlieb A, Mease P (2014) Current concepts in psoriatic arthritis: pathogenesis and management. Acta Derm Venereol 94(6):627\u2013634","journal-title":"Acta Derm Venereol"},{"issue":"9","key":"5713_CR48","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1038\/s41588-021-00913-z","volume":"53","author":"U V\u00f5sa","year":"2021","unstructured":"V\u00f5sa U, Claringbould A, Westra H-J, Bonder MJ, Deelen P, Zeng B et al (2021) Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Nat Genet 53(9):1300\u20131310","journal-title":"Nat Genet"},{"issue":"3","key":"5713_CR49","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1136\/annrheumdis-2018-214138","volume":"78","author":"SM Wade","year":"2019","unstructured":"Wade SM, Canavan M, McGarry T, Low C, Wade SC, Mullan RH et al (2019) Association of synovial tissue polyfunctional T-cells with DAPSA in psoriatic arthritis. Ann Rheum Dis 78(3):350\u2013354","journal-title":"Ann Rheum Dis"},{"issue":"7877","key":"5713_CR50","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/s41586-021-03855-y","volume":"597","author":"Q Wang","year":"2021","unstructured":"Wang Q, Dhindsa RS, Carss K, Harper AR, Nag A, Tachmazidou I et al (2021) Rare variant contribution to human disease in 281,104 UK Biobank exomes. Nature 597(7877):527\u2013532","journal-title":"Nature"},{"key":"5713_CR51","doi-asserted-by":"publisher","unstructured":"Wu Y, Zeng J, Zhang F, Zhu Z, Qi T, Zheng Z et al (2018) Integrative analysis of omics summary data reveals putative mechanisms underlyingcomplex traits. Nat Commun 9(1):918. https:\/\/doi.org\/10.1038\/s41467-018-03371-0","DOI":"10.1038\/s41467-018-03371-0"},{"key":"5713_CR52","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13479","author":"KF Yin","year":"2024","unstructured":"Yin KF, Chen T, Gu XJ, Su WM, Jiang Z, Lu SJ et al (2024) Systematic druggable genome\u2010wide Mendelian randomization identifies therapeutic targets for sarcopenia. J Cachexia Sarcopenia Muscle. https:\/\/doi.org\/10.1002\/jcsm.13479","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"5","key":"5713_CR53","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang L-G, Han Y, He Q-Y (2012) ClusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 16(5):284\u2013287","journal-title":"OMICS"},{"issue":"1","key":"5713_CR54","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1002\/jcsm.12867","volume":"13","author":"L Zanders","year":"2021","unstructured":"Zanders L, Kny M, Hahn A, Schmidt S, Wundersitz S, Todiras M et al (2021) Sepsis induces interleukin 6, gp130\/JAK2\/STAT3, and muscle wasting. J Cachexia Sarcopenia Muscle 13(1):713\u201327","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"3","key":"5713_CR55","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.62347\/BCZW1355","volume":"14","author":"Z Zhang","year":"2024","unstructured":"Zhang Z (2024) Multi-omics Mendelian randomization integrating GWAS, eQTL, and mQTL data identified genes associated with breast cancer. Am J Cancer Res 14(3):1433\u20131445","journal-title":"Am J Cancer Res"},{"issue":"5","key":"5713_CR56","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/ng.3538","volume":"48","author":"Z Zhu","year":"2016","unstructured":"Zhu Z, Zhang F, Hu H, Bakshi A, Robinson MR, Powell JE et al (2016) Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet 48(5):481\u2013487","journal-title":"Nat Genet"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05713-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05713-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05713-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:27:44Z","timestamp":1785518864000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05713-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":56,"alternative-id":["5713"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05713-y","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]},"assertion":[{"value":"26 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable. This study did not involve any human or animal experiments.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}