{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:57:58Z","timestamp":1785527878262,"version":"3.56.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Wuxi Municipal Health Commission General Project","award":["M202571"],"award-info":[{"award-number":["M202571"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"DOI":"10.1007\/s00210-026-05746-3","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T01:50:02Z","timestamp":1785203402000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Salvianolic acid B suppresses non-small cell lung cancer growth by promoting Nrf2 proteasomal degradation and triggering autophagy-dependent ferroptosis"],"prefix":"10.1007","author":[{"given":"Kejing","family":"Xi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linfang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"issue":"1","key":"5746_CR1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s12935-023-02984-w","volume":"23","author":"Y Bow","year":"2023","unstructured":"Bow Y, Ko C, Chang W, Chou S, Hung C, Huang J, Tseng C, Chen Y, Li R, Chiu C (2023) A novel quinoline derivative, dfiq, sensitizes nsclc cells to ferroptosis by promoting oxidative stress accompanied by autophagic dysfunction and mitochondrial damage. Cancer Cell Int 23(1):171. https:\/\/doi.org\/10.1186\/s12935-023-02984-w","journal-title":"Cancer Cell Int"},{"issue":"8","key":"5746_CR2","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s12032-025-02892-1","volume":"42","author":"W Chanda","year":"2025","unstructured":"Chanda W, Miyanda PM, Kamvuma K, Almarhoon ZM, Sharifi-Rad J, Setzer WN, Calina D (2025) Salvianolic acid b in cancer therapy: pharmacokinetic profile, anticancer mechanisms and translational potential. Medical Oncology (Northwood, London, England) 42(8):347. https:\/\/doi.org\/10.1007\/s12032-025-02892-1","journal-title":"Medical Oncology (Northwood, London, England)"},{"issue":"39","key":"5746_CR3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2306288120","volume":"120","author":"Y Chen","year":"2023","unstructured":"Chen Y, Shi J, Wang X, Zhou L, Wang Q, Xie Y, Peng C, Kuang L, Yang D, Yang J, Yang C, Li X, Yuan Y, Zhou Y, Peng A, Zhang Y, Chen H, Liu X, Zheng L, Huang K, Li Y (2023) An antioxidant feedforward cycle coordinated by linker histone variant H1.2 and NRF2 that drives nonsmall cell lung cancer progression. Proc Natl Acad Sci U S A 120(39):e1988679176. https:\/\/doi.org\/10.1073\/pnas.2306288120","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"5746_CR4","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1038\/s42003-025-08776-4","volume":"8","author":"S Chen","year":"2025","unstructured":"Chen S, Zhuo A, Tang R, Su S, Wen B, Wei W, Xie J, Yu Z, Rao B, Lu J, Deng Y, Zhang Z, Yang L (2025) A-to-i edited snhg3 promotes non-small cell lung cancer metastasis by promoting fatty acid oxidation and resisting ferroptosis. Commun Biol 8(1):1333. https:\/\/doi.org\/10.1038\/s42003-025-08776-4","journal-title":"Commun Biol"},{"key":"5746_CR5","doi-asserted-by":"publisher","first-page":"1146309","DOI":"10.3389\/fphar.2023.1146309","volume":"14","author":"J Cheng","year":"2023","unstructured":"Cheng J, Long J, Zhang J, Han L, Hu Y, Liu J, Qiu R, Zhu Z, Fan H (2023) Safety, tolerance, and pharmacokinetics of salvianolic acid b in healthy chinese volunteers: a randomized, double-blind, placebo-controlled phase 1 clinical trial. Front Pharmacol 14:1146309. https:\/\/doi.org\/10.3389\/fphar.2023.1146309","journal-title":"Front Pharmacol"},{"issue":"3","key":"5746_CR6","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.ccell.2023.12.021","volume":"42","author":"L Cords","year":"2024","unstructured":"Cords L, Engler S, Haberecker M, R\u00fcschoff JH, Moch H, de Souza N, Bodenmiller B (2024) Cancer-associated fibroblast phenotypes are associated with patient outcome in non-small cell lung cancer. Cancer Cell 42(3):396\u2013412. https:\/\/doi.org\/10.1016\/j.ccell.2023.12.021","journal-title":"Cancer Cell"},{"key":"5746_CR7","doi-asserted-by":"publisher","first-page":"103039","DOI":"10.1016\/j.redox.2024.103039","volume":"70","author":"J Deng","year":"2024","unstructured":"Deng J, Lin X, Qin J, Li Q, Zhang Y, Zhang Q, Ji C, Shen S, Li Y, Zhang B, Lin N (2024) Sptbn2 suppresses ferroptosis in nsclc cells by facilitating slc7a11 membrane trafficking and localization. Redox Biol 70:103039. https:\/\/doi.org\/10.1016\/j.redox.2024.103039","journal-title":"Redox Biol"},{"key":"5746_CR8","doi-asserted-by":"publisher","first-page":"101107","DOI":"10.1016\/j.redox.2019.101107","volume":"23","author":"M Dodson","year":"2019","unstructured":"Dodson M, Castro-Portuguez R, Zhang DD (2019) Nrf2 plays a critical role in mitigating lipid peroxidation and ferroptosis. Redox Biol 23:101107. https:\/\/doi.org\/10.1016\/j.redox.2019.101107","journal-title":"Redox Biol"},{"issue":"16","key":"5746_CR9","doi-asserted-by":"publisher","first-page":"12669","DOI":"10.3390\/ijms241612669","volume":"24","author":"AM Elshazly","year":"2023","unstructured":"Elshazly AM, Gewirtz DA (2023) Cytoprotective, cytotoxic and cytostatic roles of autophagy in response to bet inhibitors. Int J Mol Sci 24(16):12669. https:\/\/doi.org\/10.3390\/ijms241612669","journal-title":"Int J Mol Sci"},{"key":"5746_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103029","volume":"69","author":"Y Fu","year":"2024","unstructured":"Fu Y, Zhou X, Wang L, Fan W, Gao S, Zhang D, Ling Z, Zhang Y, Ma L, Bai F, Chen J, Sun B, Liu P (2024) Salvianolic acid b attenuates liver fibrosis by targeting ecm1 and inhibiting hepatocyte ferroptosis. Redox Biol 69:103029. https:\/\/doi.org\/10.1016\/j.redox.2024.103029","journal-title":"Redox Biol"},{"issue":"1","key":"5746_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-024-09930-0","volume":"40","author":"L Guo","year":"2024","unstructured":"Guo L, Yang Y, Ma J, Xiao M, Cao R, Xi Y, Li T, Huang T, Yan M (2024) Triptolide induces hepatotoxicity by promoting ferroptosis through Nrf2 degradation. Cell Biol Toxicol 40(1):94. https:\/\/doi.org\/10.1007\/s10565-024-09930-0","journal-title":"Cell Biol Toxicol"},{"issue":"5","key":"5746_CR12","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3892\/mmr.2022.12700","volume":"25","author":"G Han","year":"2022","unstructured":"Han G, Wang Y, Liu T, Gao J, Duan F, Chen M, Yang Y, Wu C (2022) Salvianolic acid b acts against non-small cell lung cancer A549 cells via inactivation of the MAPK and SMAD2\/3 signaling pathways. Mol Med Rep 25(5):184. https:\/\/doi.org\/10.3892\/mmr.2022.12700","journal-title":"Mol Med Rep"},{"issue":"2","key":"5746_CR13","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s40139-017-0139-5","volume":"5","author":"R Kang","year":"2017","unstructured":"Kang R, Tang D (2017) Autophagy and ferroptosis - what\u2019s the connection? Curr Pathobiol Rep 5(2):153\u2013159. https:\/\/doi.org\/10.1007\/s40139-017-0139-5","journal-title":"Curr Pathobiol Rep"},{"issue":"7","key":"5746_CR14","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1038\/s41419-023-05978-8","volume":"14","author":"S Lee","year":"2023","unstructured":"Lee S, Hwang N, Seok BG, Lee S, Lee S, Chung SW (2023) Autophagy mediates an amplification loop during ferroptosis. Cell Death Dis 14(7):464. https:\/\/doi.org\/10.1038\/s41419-023-05978-8","journal-title":"Cell Death Dis"},{"key":"5746_CR15","doi-asserted-by":"publisher","first-page":"114950","DOI":"10.1016\/j.biopha.2023.114950","volume":"164","author":"B Li","year":"2023","unstructured":"Li B, Wang Y, Jiang X, Du H, Shi Y, Xiu M, Liu Y, He J (2023) Natural products targeting nrf2\/are signaling pathway in the treatment of inflammatory bowel disease. Biomed Pharmacother Biomedecine Pharmacotherapie 164:114950. https:\/\/doi.org\/10.1016\/j.biopha.2023.114950","journal-title":"Biomed Pharmacother Biomedecine Pharmacotherapie"},{"key":"5746_CR16","doi-asserted-by":"publisher","first-page":"101154","DOI":"10.1016\/j.drup.2024.101154","volume":"77","author":"Z Liu","year":"2024","unstructured":"Liu Z, Liu C, Fan C, Li R, Zhang S, Liu J, Li B, Zhang S, Guo L, Wang X, Qi Z, Shen Y (2024) E3 ubiquitin ligase dtx2 fosters ferroptosis resistance via suppressing ncoa4-mediated ferritinophagy in non-small cell lung cancer. Drug Resist Updates 77:101154. https:\/\/doi.org\/10.1016\/j.drup.2024.101154","journal-title":"Drug Resist Updates"},{"issue":"1","key":"5746_CR17","doi-asserted-by":"publisher","first-page":"4703","DOI":"10.1038\/s41467-024-48364-4","volume":"15","author":"W Lu","year":"2024","unstructured":"Lu W, Cui J, Wang W, Hu Q, Xue Y, Liu X, Gong T, Lu Y, Ma H, Yang X, Feng B, Wang Q, Zhang N, Xu Y, Liu M, Nussinov R, Cheng F, Ji H, Huang J (2024) Ppia dictates nrf2 stability to promote lung cancer progression. Nat Commun 15(1):4703. https:\/\/doi.org\/10.1038\/s41467-024-48364-4","journal-title":"Nat Commun"},{"issue":"2","key":"5746_CR18","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.chembiol.2023.10.012","volume":"31","author":"J Mann","year":"2024","unstructured":"Mann J, Reznik E, Santer M, Fongheiser MA, Smith N, Hirschhorn T, Zandkarimi F, Soni RK, Dafr\u00e9 AL, Miranda-Vizuete A, Farina M, Stockwell BR (2024) Ferroptosis inhibition by oleic acid mitigates iron-overload-induced injury. Cell Chem Biol 31(2):249\u2013264. https:\/\/doi.org\/10.1016\/j.chembiol.2023.10.012","journal-title":"Cell Chem Biol"},{"issue":"2","key":"5746_CR19","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1111\/imm.13562","volume":"168","author":"H Sadeghirad","year":"2023","unstructured":"Sadeghirad H, Bahrami T, Layeghi SM, Yousefi H, Rezaei M, Hosseini-Fard SR, Radfar P, Warkiani ME, O\u2019Byrne K, Kulasinghe A (2023) Immunotherapeutic targets in non-small cell lung cancer. Immunology 168(2):256\u2013272. https:\/\/doi.org\/10.1111\/imm.13562","journal-title":"Immunology"},{"issue":"11","key":"5746_CR20","doi-asserted-by":"publisher","first-page":"3214","DOI":"10.1021\/acschembio.6b00651","volume":"11","author":"A Singh","year":"2016","unstructured":"Singh A, Venkannagari S, Oh KH, Zhang Y, Rohde JM, Liu L, Nimmagadda S, Sudini K, Brimacombe KR, Gajghate S, Ma J, Wang A, Xu X, Shahane SA, Xia M, Woo J, Mensah GA, Wang Z, Ferrer M, Gabrielson E, Li Z, Rastinejad F, Shen M, Boxer MB, Biswal S (2016) Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors. ACS Chem Biol 11(11):3214\u20133225. https:\/\/doi.org\/10.1021\/acschembio.6b00651","journal-title":"ACS Chem Biol"},{"issue":"1","key":"5746_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s11658-020-00245-6","volume":"26","author":"M Tracz","year":"2021","unstructured":"Tracz M, Bialek W (2021) Beyond k48 and k63: non-canonical protein ubiquitination. Cell Mol Biol Lett 26(1):1. https:\/\/doi.org\/10.1186\/s11658-020-00245-6","journal-title":"Cell Mol Biol Lett"},{"issue":"9","key":"5746_CR22","doi-asserted-by":"publisher","first-page":"3585","DOI":"10.1093\/plcell\/koad159","volume":"35","author":"X Wang","year":"2023","unstructured":"Wang X, Zhang X, Song C, Gong Z, Yang S, Ding Y (2023) Pub25 and pub26 dynamically modulate ice1 stability via differential ubiquitination during cold stress in Arabidopsis. Plant Cell 35(9):3585\u20133603. https:\/\/doi.org\/10.1093\/plcell\/koad159","journal-title":"Plant Cell"},{"issue":"13","key":"5746_CR23","doi-asserted-by":"publisher","first-page":"5145","DOI":"10.7150\/ijbs.96748","volume":"20","author":"J Wang","year":"2024","unstructured":"Wang J, Zhuang H, Yang X, Guo Z, Zhou K, Liu N, An Y, Chen Y, Zhang Z, Wang M, Chen J, Li C, Chang X (2024a) Exploring the mechanism of ferroptosis induction by sappanone A in cancer: insights into the mitochondrial dysfunction mediated by NRF2\/XCT\/GPX4 axis. Int J Biol Sci 20(13):5145\u20135161. https:\/\/doi.org\/10.7150\/ijbs.96748","journal-title":"Int J Biol Sci"},{"issue":"1","key":"5746_CR24","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41418-023-01239-5","volume":"31","author":"Z Wang","year":"2024","unstructured":"Wang Z, Shen N, Wang Z, Yu L, Yang S, Wang Y, Liu Y, Han G, Zhang Q (2024b) Trim3 facilitates ferroptosis in non-small cell lung cancer through promoting slc7a11\/xct k11-linked ubiquitination and degradation. Cell Death Differ 31(1):53\u201364. https:\/\/doi.org\/10.1038\/s41418-023-01239-5","journal-title":"Cell Death Differ"},{"key":"5746_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154881","volume":"116","author":"R Wen","year":"2023","unstructured":"Wen R, Dong X, Zhuang H, Pang F, Ding S, Li N, Mai Y, Zhou S, Wang J, Zhang J (2023) Baicalin induces ferroptosis in osteosarcomas through a novel nrf2\/xct\/gpx4 regulatory axis. Phytomedicine 116:154881. https:\/\/doi.org\/10.1016\/j.phymed.2023.154881","journal-title":"Phytomedicine"},{"issue":"8","key":"5746_CR26","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1038\/s12276-022-00829-6","volume":"54","author":"Q Xiang","year":"2022","unstructured":"Xiang Q, Zhao Y, Lin J, Jiang S, Li W (2022) The nrf2 antioxidant defense system in intervertebral disc degeneration: molecular insights. Exp Mol Med 54(8):1067\u20131075. https:\/\/doi.org\/10.1038\/s12276-022-00829-6","journal-title":"Exp Mol Med"},{"issue":"7","key":"5746_CR27","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s12032-024-02413-6","volume":"41","author":"Y Yang","year":"2024","unstructured":"Yang Y, Huang L, Gao J, Qian B (2024) Salvianolic acid b inhibits the growth and metastasis of a549 lung cancer cells through the ndrg2\/pten pathway by inducing oxidative stress. Med Oncol (Northwood, London, England) 41(7):170. https:\/\/doi.org\/10.1007\/s12032-024-02413-6","journal-title":"Med Oncol (Northwood, London, England)"},{"issue":"1","key":"5746_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-32336-9","volume":"15","author":"Y Yang","year":"2025","unstructured":"Yang Y, Huang L, Dai L, Zhou X, Qian B (2025) Salvianolic acid b inhibits the proliferation and metastasis of a549 lung cancer cells via mir-23a\/pten\/akt pathway. Sci Rep 15(1):45066. https:\/\/doi.org\/10.1038\/s41598-025-32336-9","journal-title":"Sci Rep"},{"key":"5746_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2022.153823","volume":"233","author":"FA Zadeh","year":"2022","unstructured":"Zadeh FA, Raji A, Ali SA, Abdelbasset WK, Alekhina N, Iswanto AH, Terefe EM, Jalil AT (2022) Autophagy-related chemoradiotherapy sensitivity in non-small cell lung cancer (NSCLC). Pathol Res Pract 233:153823. https:\/\/doi.org\/10.1016\/j.prp.2022.153823","journal-title":"Pathol Res Pract"},{"issue":"6","key":"5746_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22063245","volume":"22","author":"LX Zampieri","year":"2021","unstructured":"Zampieri LX, Silva-Almeida C, Rondeau JD, Sonveaux P (2021) Mitochondrial transfer in cancer: a comprehensive review. Int J Mol Sci 22(6):3245. https:\/\/doi.org\/10.3390\/ijms22063245","journal-title":"Int J Mol Sci"},{"key":"5746_CR31","doi-asserted-by":"publisher","first-page":"9302403","DOI":"10.1155\/2022\/9302403","volume":"2022","author":"H Zhang","year":"2022","unstructured":"Zhang H, Tang J, Cao Y, Wang T (2022) Salvianolic acid b suppresses non-small-cell lung cancer metastasis through pkm2-independent metabolic reprogramming. Evidence-Based Complement Alternat Med\u202f: Ecam 2022:9302403. https:\/\/doi.org\/10.1155\/2022\/9302403","journal-title":"Evidence-Based Complement Alternat Med : Ecam"},{"key":"5746_CR32","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.semcancer.2019.03.002","volume":"66","author":"B Zhou","year":"2020","unstructured":"Zhou B, Liu J, Kang R, Klionsky DJ, Kroemer G, Tang D (2020) Ferroptosis is a type of autophagy-dependent cell death. Semin Cancer Biol 66:89\u2013100. https:\/\/doi.org\/10.1016\/j.semcancer.2019.03.002","journal-title":"Semin Cancer Biol"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05746-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05746-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05746-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:15:30Z","timestamp":1785521730000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05746-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":32,"alternative-id":["5746"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05746-3","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]},"assertion":[{"value":"9 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}