{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:58:53Z","timestamp":1785769133050,"version":"3.56.0"},"reference-count":74,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"DOI":"10.1007\/s00210-026-05764-1","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T01:40:18Z","timestamp":1785721218000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacological evolution of natural product\u2013based and chemically engineered autophagy-modulating strategies in neurodegenerative diseases: a bibliometric mapping analysis (2006\u20132025)"],"prefix":"10.1007","author":[{"given":"Menghao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"issue":"6","key":"5764_CR1","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1021\/mp700113r","volume":"4","author":"P Anand","year":"2007","unstructured":"Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB (2007) Bioavailability of curcumin: problems and promises. Mol Pharm 4(6):807\u2013818. https:\/\/doi.org\/10.1021\/mp700113r","journal-title":"Mol Pharm"},{"issue":"11","key":"5764_CR2","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1111\/bph.13779","volume":"174","author":"R Andrew","year":"2017","unstructured":"Andrew R, Izzo AA (2017) Principles of pharmacological research of nutraceuticals. Br J Pharmacol 174(11):1177\u20131194. https:\/\/doi.org\/10.1111\/bph.13779","journal-title":"Br J Pharmacol"},{"issue":"4","key":"5764_CR3","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.joi.2017.08.007","volume":"11","author":"M Aria","year":"2017","unstructured":"Aria M, Cuccurullo C (2017) Bibliometrix: an R-tool for comprehensive science mapping analysis. J Informetr 11(4):959\u2013975. https:\/\/doi.org\/10.1016\/j.joi.2017.08.007","journal-title":"J Informetr"},{"issue":"3","key":"5764_CR4","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","volume":"20","author":"AG Atanasov","year":"2021","unstructured":"Atanasov AG, Zotchev SB, Dirsch VM, Supuran CT (2021) Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov 20(3):200\u2013216. https:\/\/doi.org\/10.1038\/s41573-020-00114-z","journal-title":"Nat Rev Drug Discov"},{"key":"5764_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.5","volume":"1","author":"GP Bates","year":"2015","unstructured":"Bates GP, Dorsey R, Gusella JF, Hayden MR, Kay C, Leavitt BR et al (2015) Huntington disease. Nat Rev Dis Primers 1:15005. https:\/\/doi.org\/10.1038\/nrdp.2015.5","journal-title":"Nat Rev Dis Primers"},{"issue":"7391","key":"5764_CR6","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/483531a","volume":"483","author":"CG Begley","year":"2012","unstructured":"Begley CG, Ellis LM (2012) Drug development: raise standards for preclinical cancer research. Nature 483(7391):531\u2013533. https:\/\/doi.org\/10.1038\/483531a","journal-title":"Nature"},{"key":"5764_CR7","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1146\/annurev-biochem-060815-014556","volume":"85","author":"CF Bento","year":"2016","unstructured":"Bento CF, Renna M, Ghislat G, Puri C, Ashkenazi A, Vicinanza M et al (2016) Mammalian autophagy: how does it work? Annu Rev Biochem 85:685\u2013713. https:\/\/doi.org\/10.1146\/annurev-biochem-060815-014556","journal-title":"Annu Rev Biochem"},{"issue":"10291","key":"5764_CR8","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1016\/s0140-6736(21)00218-x","volume":"397","author":"BR Bloem","year":"2021","unstructured":"Bloem BR, Okun MS, Klein C (2021) Parkinson\u2019s disease. Lancet 397(10291):2284\u20132303. https:\/\/doi.org\/10.1016\/s0140-6736(21)00218-x","journal-title":"Lancet"},{"issue":"2","key":"5764_CR9","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1056\/NEJMra1603471","volume":"377","author":"RH Brown","year":"2017","unstructured":"Brown RH, Al-Chalabi A (2017) Amyotrophic lateral sclerosis. N Engl J Med 377(2):162\u2013172. https:\/\/doi.org\/10.1056\/NEJMra1603471","journal-title":"N Engl J Med"},{"issue":"8","key":"5764_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/biom13081196","volume":"13","author":"V Chandrasekaran","year":"2023","unstructured":"Chandrasekaran V, Hediyal TA, Anand N, Kendaganna PH, Gorantla VR, Mahalakshmi AM et al (2023) Polyphenols, autophagy and neurodegenerative diseases: a review. Biomolecules 13(8):1196. https:\/\/doi.org\/10.3390\/biom13081196","journal-title":"Biomolecules"},{"issue":"10","key":"5764_CR11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0223994","volume":"14","author":"C Chen","year":"2019","unstructured":"Chen C, Song M (2019) Visualizing a field of research: a methodology of systematic scientometric reviews. PLoS ONE 14(10):e0223994. https:\/\/doi.org\/10.1371\/journal.pone.0223994","journal-title":"PLoS ONE"},{"issue":"7","key":"5764_CR12","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1002\/asi.21309","volume":"61","author":"C Chen","year":"2010","unstructured":"Chen C, Ibekwe-SanJuan F, Hou J (2010) The structure and dynamics of cocitation clusters: a multiple-perspective cocitation analysis. J Am Soc Inf Sci Technol 61(7):1386\u20131409. https:\/\/doi.org\/10.1002\/asi.21309","journal-title":"J Am Soc Inf Sci Technol"},{"issue":"5688","key":"5764_CR13","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1126\/science.1101738","volume":"305","author":"AM Cuervo","year":"2004","unstructured":"Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D (2004) Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305(5688):1292\u20131295. https:\/\/doi.org\/10.1126\/science.1101738","journal-title":"Science"},{"issue":"6","key":"5764_CR14","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/s41580-018-0003-4","volume":"19","author":"I Dikic","year":"2018","unstructured":"Dikic I, Elazar Z (2018) Mechanism and medical implications of mammalian autophagy. Nat Rev Mol Cell Biol 19(6):349\u2013364. https:\/\/doi.org\/10.1038\/s41580-018-0003-4","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"5764_CR15","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1080\/15548627.2019.1704119","volume":"16","author":"Y Dong","year":"2020","unstructured":"Dong Y, Hu Y, Sarkar S, Zong WX, Li M, Feng D et al (2020) Autophagy modulator scoring system: a user-friendly tool for quantitative analysis of methodological integrity of chemical autophagy modulator studies. Autophagy 16(2):195\u2013202. https:\/\/doi.org\/10.1080\/15548627.2019.1704119","journal-title":"Autophagy"},{"key":"5764_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106835","volume":"194","author":"Y Dong","year":"2023","unstructured":"Dong Y, Zhuang XX, Wang YT, Tan J, Feng D, Li M et al (2023) Chemical mitophagy modulators: drug development strategies and novel regulatory mechanisms. Pharmacol Res 194:106835. https:\/\/doi.org\/10.1016\/j.phrs.2023.106835","journal-title":"Pharmacol Res"},{"key":"5764_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-026-01667-x","author":"Y Dong","year":"2026","unstructured":"Dong Y, Xiao X, Zhuang XX, Wu W, Wang ZY, Zhang S et al (2026) DeepDrugDiscovery identifies blood\u2013brain barrier permeable autophagy enhancers for Alzheimer\u2019s disease. Nat Biomed Eng. https:\/\/doi.org\/10.1038\/s41551-026-01667-x","journal-title":"Nat Biomed Eng"},{"key":"5764_CR18","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.jbusres.2021.04.070","volume":"133","author":"N Donthu","year":"2021","unstructured":"Donthu N, Kumar S, Mukherjee D, Pandey N, Lim WM (2021) How to conduct a bibliometric analysis: an overview and guidelines. J Bus Res 133:285\u2013296. https:\/\/doi.org\/10.1016\/j.jbusres.2021.04.070","journal-title":"J Bus Res"},{"issue":"4","key":"5764_CR19","doi-asserted-by":"publisher","first-page":"17r","DOI":"10.1093\/glycob\/cwg047","volume":"13","author":"AD Elbein","year":"2003","unstructured":"Elbein AD, Pan YT, Pastuszak I, Carroll D (2003) New insights on trehalose: a multifunctional molecule. Glycobiology 13(4):17r\u201327r. https:\/\/doi.org\/10.1093\/glycob\/cwg047","journal-title":"Glycobiology"},{"key":"5764_CR20","doi-asserted-by":"publisher","unstructured":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019. Lancet Public Health. 2022;7(2):e105-e25. https:\/\/doi.org\/10.1016\/s2468-2667(21)00249-8.","DOI":"10.1016\/s2468-2667(21)00249-8"},{"issue":"2","key":"5764_CR21","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1096\/fj.07-9492LSF","volume":"22","author":"ME Falagas","year":"2008","unstructured":"Falagas ME, Pitsouni EI, Malietzis GA, Pappas G (2008) Comparison of PubMed, Scopus, Web of Science, and Google Scholar: strengths and weaknesses. FASEB J 22(2):338\u2013342. https:\/\/doi.org\/10.1096\/fj.07-9492LSF","journal-title":"FASEB J"},{"issue":"1","key":"5764_CR22","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1172\/jci73944","volume":"125","author":"RA Frake","year":"2015","unstructured":"Frake RA, Ricketts T, Menzies FM, Rubinsztein DC (2015) Autophagy and neurodegeneration. J Clin Invest 125(1):65\u201374. https:\/\/doi.org\/10.1172\/jci73944","journal-title":"J Clin Invest"},{"issue":"9","key":"5764_CR23","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1038\/cr.2016.95","volume":"26","author":"M Gao","year":"2016","unstructured":"Gao M, Monian P, Pan Q, Zhang W, Xiang J, Jiang X (2016) Ferroptosis is an autophagic cell death process. Cell Res 26(9):1021\u20131032. https:\/\/doi.org\/10.1038\/cr.2016.95","journal-title":"Cell Res"},{"key":"5764_CR24","doi-asserted-by":"publisher","unstructured":"Global, regional, and national burden of disorders affecting the nervous system, 1990\u20132021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Neurol. 2024;23(4):344\u201381. https:\/\/doi.org\/10.1016\/s1474-4422(24)00038-3.","DOI":"10.1016\/s1474-4422(24)00038-3"},{"issue":"1","key":"5764_CR25","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/s43856-025-00904-9","volume":"5","author":"MM Gonzales","year":"2025","unstructured":"Gonzales MM, Garbarino VR, Kautz TF, Song X, Lopez-Cruzan M, Linehan L et al (2025) Rapamycin treatment for Alzheimer\u2019s disease and related dementias: a pilot phase 1 clinical trial. Commun Med (Lond) 5(1):189. https:\/\/doi.org\/10.1038\/s43856-025-00904-9","journal-title":"Commun Med (Lond)"},{"issue":"9","key":"5764_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092844","volume":"19","author":"L Gu","year":"2018","unstructured":"Gu L, Yu Q, Li Q, Zhang L, Lu H, Zhang X (2018) Andrographolide protects PC12 cells against \u03b2-amyloid-induced autophagy-associated cell death through activation of the Nrf2-mediated p62 signaling pathway. Int J Mol Sci 19(9):2844. https:\/\/doi.org\/10.3390\/ijms19092844","journal-title":"Int J Mol Sci"},{"issue":"5","key":"5764_CR27","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/j.1755-5949.2010.00147.x","volume":"16","author":"T Hamaguchi","year":"2010","unstructured":"Hamaguchi T, Ono K, Yamada M (2010) Review: curcumin and Alzheimer\u2019s disease. CNS Neurosci Ther 16(5):285\u2013297. https:\/\/doi.org\/10.1111\/j.1755-5949.2010.00147.x","journal-title":"CNS Neurosci Ther"},{"issue":"4","key":"5764_CR28","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nrm3311","volume":"13","author":"DG Hardie","year":"2012","unstructured":"Hardie DG, Ross FA, Hawley SA (2012) AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 13(4):251\u2013262. https:\/\/doi.org\/10.1038\/nrm3311","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"5764_CR29","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/s1474-4422(15)70016-5","volume":"14","author":"MT Heneka","year":"2015","unstructured":"Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL et al (2015) Neuroinflammation in Alzheimer\u2019s disease. Lancet Neurol 14(4):388\u2013405. https:\/\/doi.org\/10.1016\/s1474-4422(15)70016-5","journal-title":"Lancet Neurol"},{"issue":"11","key":"5764_CR30","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/nchembio.118","volume":"4","author":"AL Hopkins","year":"2008","unstructured":"Hopkins AL (2008) Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 4(11):682\u2013690. https:\/\/doi.org\/10.1038\/nchembio.118","journal-title":"Nat Chem Biol"},{"issue":"8","key":"5764_CR31","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1080\/15548627.2016.1187366","volume":"12","author":"W Hou","year":"2016","unstructured":"Hou W, Xie Y, Song X, Sun X, Lotze MT, Zeh HJ 3rd et al (2016) Autophagy promotes ferroptosis by degradation of ferritin. Autophagy 12(8):1425\u20131428. https:\/\/doi.org\/10.1080\/15548627.2016.1187366","journal-title":"Autophagy"},{"key":"5764_CR32","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.exger.2017.02.004","volume":"91","author":"M Huang","year":"2017","unstructured":"Huang M, Jiang X, Liang Y, Liu Q, Chen S, Guo Y (2017) Berberine improves cognitive impairment by promoting autophagic clearance and inhibiting production of \u03b2-amyloid in APP\/tau\/PS1 mouse model of Alzheimer\u2019s disease. Exp Gerontol 91:25\u201333. https:\/\/doi.org\/10.1016\/j.exger.2017.02.004","journal-title":"Exp Gerontol"},{"issue":"10","key":"5764_CR33","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1111\/bph.15054","volume":"177","author":"AA Izzo","year":"2020","unstructured":"Izzo AA, Teixeira M, Alexander SPH, Cirino G, Docherty JR, George CH et al (2020) A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology: Reproducibility of natural product research. Br J Pharmacol 177(10):2169\u20132178. https:\/\/doi.org\/10.1111\/bph.15054","journal-title":"Br J Pharmacol"},{"issue":"8","key":"5764_CR34","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1136\/jnnp-2019-322338","volume":"91","author":"J Jankovic","year":"2020","unstructured":"Jankovic J, Tan EK (2020) Parkinson\u2019s disease: etiopathogenesis and treatment. J Neurol Neurosurg Psychiatry 91(8):795\u2013808. https:\/\/doi.org\/10.1136\/jnnp-2019-322338","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"5764_CR35","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28520-4","volume":"13","author":"CH Ji","year":"2022","unstructured":"Ji CH, Kim HY, Lee MJ, Heo AJ, Park DY, Lim S et al (2022) The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun 13(1):904. https:\/\/doi.org\/10.1038\/s41467-022-28520-4","journal-title":"Nat Commun"},{"issue":"6","key":"5764_CR36","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/s41580-018-0001-6","volume":"19","author":"S Kaushik","year":"2018","unstructured":"Kaushik S, Cuervo AM (2018) The coming of age of chaperone-mediated autophagy. Nat Rev Mol Cell Biol 19(6):365\u2013381. https:\/\/doi.org\/10.1038\/s41580-018-0001-6","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"5764_CR37","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1172\/jci73939","volume":"125","author":"YC Kim","year":"2015","unstructured":"Kim YC, Guan KL (2015) mTOR: a pharmacologic target for autophagy regulation. J Clin Invest 125(1):25\u201332. https:\/\/doi.org\/10.1172\/jci73939","journal-title":"J Clin Invest"},{"issue":"2","key":"5764_CR38","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/ncb2152","volume":"13","author":"J Kim","year":"2011","unstructured":"Kim J, Kundu M, Viollet B, Guan KL (2011) AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 13(2):132\u2013141. https:\/\/doi.org\/10.1038\/ncb2152","journal-title":"Nat Cell Biol"},{"issue":"1","key":"5764_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15548627.2020.1797280","volume":"17","author":"DJ Klionsky","year":"2021","unstructured":"Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S et al (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). Autophagy 17(1):1\u2013382. https:\/\/doi.org\/10.1080\/15548627.2020.1797280","journal-title":"Autophagy"},{"issue":"8","key":"5764_CR40","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1038\/nrd1470","volume":"3","author":"I Kola","year":"2004","unstructured":"Kola I, Landis J (2004) Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov 3(8):711\u2013715. https:\/\/doi.org\/10.1038\/nrd1470","journal-title":"Nat Rev Drug Discov"},{"issue":"6","key":"5764_CR41","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/j.cell.2007.10.035","volume":"131","author":"M Komatsu","year":"2007","unstructured":"Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T et al (2007) Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131(6):1149\u20131163. https:\/\/doi.org\/10.1016\/j.cell.2007.10.035","journal-title":"Cell"},{"issue":"9","key":"5764_CR42","doi-asserted-by":"publisher","DOI":"10.3390\/nu9090927","volume":"9","author":"X Kou","year":"2017","unstructured":"Kou X, Chen N (2017) Resveratrol as a natural autophagy regulator for prevention and treatment of Alzheimer\u2019s disease. Nutrients 9(9):927. https:\/\/doi.org\/10.3390\/nu9090927","journal-title":"Nutrients"},{"issue":"6","key":"5764_CR43","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/S1474-4422(25)00173-5","volume":"24","author":"S Ladha","year":"2025","unstructured":"Ladha S, Chibnik L, Quintana M, Wang J, Macklin E, Saville B et al (2025) Safety and efficacy of trehalose in amyotrophic lateral sclerosis (HEALEY ALS Platform Trial): an adaptive, phase 2\/3, double-blind, randomised, placebo-controlled trial. Lancet Neurol 24(6):500\u2013511. https:\/\/doi.org\/10.1016\/S1474-4422(25)00173-5","journal-title":"Lancet Neurol"},{"issue":"1-2","key":"5764_CR44","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.cell.2018.09.048","volume":"176","author":"B Levine","year":"2019","unstructured":"Levine B, Kroemer G (2019) Biological functions of autophagy genes: a disease perspective. Cell 176(1\u20132):11\u201342. https:\/\/doi.org\/10.1016\/j.cell.2018.09.048","journal-title":"Cell"},{"issue":"7781","key":"5764_CR45","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/s41586-019-1722-1","volume":"575","author":"Z Li","year":"2019","unstructured":"Li Z, Wang C, Wang Z, Zhu C, Li J, Sha T et al (2019) Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature 575(7781):203\u2013209. https:\/\/doi.org\/10.1038\/s41586-019-1722-1","journal-title":"Nature"},{"issue":"17","key":"5764_CR46","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1038\/emboj.2013.171","volume":"32","author":"I Maejima","year":"2013","unstructured":"Maejima I, Takahashi A, Omori H, Kimura T, Takabatake Y, Saitoh T et al (2013) Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury. EMBO J 32(17):2336\u20132347. https:\/\/doi.org\/10.1038\/emboj.2013.171","journal-title":"EMBO J"},{"issue":"5","key":"5764_CR47","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/nn.2528","volume":"13","author":"M Martinez-Vicente","year":"2010","unstructured":"Martinez-Vicente M, Talloczy Z, Wong E, Tang G, Koga H, Kaushik S et al (2010) Cargo recognition failure is responsible for inefficient autophagy in Huntington\u2019s disease. Nat Neurosci 13(5):567\u201376. https:\/\/doi.org\/10.1038\/nn.2528","journal-title":"Nat Neurosci"},{"issue":"6","key":"5764_CR48","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/nrn3961","volume":"16","author":"FM Menzies","year":"2015","unstructured":"Menzies FM, Fleming A, Rubinsztein DC (2015) Compromised autophagy and neurodegenerative diseases. Nat Rev Neurosci 16(6):345\u2013357. https:\/\/doi.org\/10.1038\/nrn3961","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"5764_CR49","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","volume":"147","author":"N Mizushima","year":"2011","unstructured":"Mizushima N, Komatsu M (2011) Autophagy: renovation of cells and tissues. Cell 147(4):728\u2013741. https:\/\/doi.org\/10.1016\/j.cell.2011.10.026","journal-title":"Cell"},{"issue":"3","key":"5764_CR50","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","volume":"140","author":"N Mizushima","year":"2010","unstructured":"Mizushima N, Yoshimori T, Levine B (2010) Methods in mammalian autophagy research. Cell 140(3):313\u2013326. https:\/\/doi.org\/10.1016\/j.cell.2010.01.028","journal-title":"Cell"},{"issue":"1","key":"5764_CR51","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s11192-015-1765-5","volume":"106","author":"P Mongeon","year":"2016","unstructured":"Mongeon P, Paul-Hus A (2016) The journal coverage of Web of Science and Scopus: a comparative analysis. Scientometrics 106(1):213\u2013228. https:\/\/doi.org\/10.1007\/s11192-015-1765-5","journal-title":"Scientometrics"},{"issue":"5","key":"5764_CR52","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1083\/jcb.200809125","volume":"183","author":"D Narendra","year":"2008","unstructured":"Narendra D, Tanaka A, Suen DF, Youle RJ (2008) Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 183(5):795\u2013803. https:\/\/doi.org\/10.1083\/jcb.200809125","journal-title":"J Cell Biol"},{"issue":"3","key":"5764_CR53","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","volume":"83","author":"DJ Newman","year":"2020","unstructured":"Newman DJ, Cragg GM (2020) Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019. J Nat Prod 83(3):770\u2013803. https:\/\/doi.org\/10.1021\/acs.jnatprod.9b01285","journal-title":"J Nat Prod"},{"issue":"8","key":"5764_CR54","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/nm.3232","volume":"19","author":"RA Nixon","year":"2013","unstructured":"Nixon RA (2013) The role of autophagy in neurodegenerative disease. Nat Med 19(8):983\u2013997. https:\/\/doi.org\/10.1038\/nm.3232","journal-title":"Nat Med"},{"issue":"11","key":"5764_CR55","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1038\/s41580-024-00757-5","volume":"25","author":"RA Nixon","year":"2024","unstructured":"Nixon RA, Rubinsztein DC (2024) Mechanisms of autophagy-lysosome dysfunction in neurodegenerative diseases. Nat Rev Mol Cell Biol 25(11):926\u2013946. https:\/\/doi.org\/10.1038\/s41580-024-00757-5","journal-title":"Nat Rev Mol Cell Biol"},{"key":"5764_CR56","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https:\/\/doi.org\/10.1136\/bmj.n71","journal-title":"BMJ"},{"issue":"9","key":"5764_CR57","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/s41556-018-0176-2","volume":"20","author":"K Palikaras","year":"2018","unstructured":"Palikaras K, Lionaki E, Tavernarakis N (2018) Mechanisms of mitophagy in cellular homeostasis, physiology and pathology. Nat Cell Biol 20(9):1013\u20131022. https:\/\/doi.org\/10.1038\/s41556-018-0176-2","journal-title":"Nat Cell Biol"},{"issue":"2","key":"5764_CR58","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","volume":"85","author":"AM Pickrell","year":"2015","unstructured":"Pickrell AM, Youle RJ (2015) The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson\u2019s disease. Neuron 85(2):257\u2013273. https:\/\/doi.org\/10.1016\/j.neuron.2014.12.007","journal-title":"Neuron"},{"issue":"9","key":"5764_CR59","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1002\/mds.25075","volume":"27","author":"T Pringsheim","year":"2012","unstructured":"Pringsheim T, Wiltshire K, Day L, Dykeman J, Steeves T, Jette N (2012) The incidence and prevalence of Huntington\u2019s disease: a systematic review and meta-analysis. Mov Disord 27(9):1083\u20131091. https:\/\/doi.org\/10.1002\/mds.25075","journal-title":"Mov Disord"},{"issue":"7113","key":"5764_CR60","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1038\/nature05291","volume":"443","author":"DC Rubinsztein","year":"2006","unstructured":"Rubinsztein DC (2006) The roles of intracellular protein-degradation pathways in neurodegeneration. Nature 443(7113):780\u2013786. https:\/\/doi.org\/10.1038\/nature05291","journal-title":"Nature"},{"issue":"9","key":"5764_CR61","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1039\/b804606a","volume":"4","author":"S Sarkar","year":"2008","unstructured":"Sarkar S, Rubinsztein DC (2008) Small molecule enhancers of autophagy for neurodegenerative diseases. Mol Biosyst 4(9):895\u2013901. https:\/\/doi.org\/10.1039\/b804606a","journal-title":"Mol Biosyst"},{"issue":"8","key":"5764_CR62","doi-asserted-by":"publisher","first-page":"5641","DOI":"10.1074\/jbc.M609532200","volume":"282","author":"S Sarkar","year":"2007","unstructured":"Sarkar S, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC (2007) Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem 282(8):5641\u20135652. https:\/\/doi.org\/10.1074\/jbc.M609532200","journal-title":"J Biol Chem"},{"issue":"6036","key":"5764_CR63","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1126\/science.1204592","volume":"332","author":"C Settembre","year":"2011","unstructured":"Settembre C, Di Malta C, Polito VA, Garcia Arencibia M, Vetrini F, Erdin S et al (2011) TFEB links autophagy to lysosomal biogenesis. Science 332(6036):1429\u20131433. https:\/\/doi.org\/10.1126\/science.1204592","journal-title":"Science"},{"issue":"1","key":"5764_CR64","doi-asserted-by":"publisher","first-page":"144","DOI":"10.4161\/auto.26751","volume":"10","author":"JX Song","year":"2014","unstructured":"Song JX, Lu JH, Liu LF, Chen LL, Durairajan SS, Yue Z et al (2014) HMGB1 is involved in autophagy inhibition caused by SNCA\/\u03b1-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B. Autophagy 10(1):144\u2013154. https:\/\/doi.org\/10.4161\/auto.26751","journal-title":"Autophagy"},{"key":"5764_CR65","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.555409","volume":"8","author":"A Stacchiotti","year":"2020","unstructured":"Stacchiotti A, Corsetti G (2020) Natural compounds and autophagy: allies against neurodegeneration. Front Cell Dev Biol 8:555409. https:\/\/doi.org\/10.3389\/fcell.2020.555409","journal-title":"Front Cell Dev Biol"},{"issue":"5","key":"5764_CR66","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.molcel.2019.09.009","volume":"76","author":"D Takahashi","year":"2019","unstructured":"Takahashi D, Moriyama J, Nakamura T, Miki E, Takahashi E, Sato A et al (2019) AUTACs: cargo-specific degraders using selective autophagy. Mol Cell 76(5):797-810.e10. https:\/\/doi.org\/10.1016\/j.molcel.2019.09.009","journal-title":"Mol Cell"},{"issue":"10130","key":"5764_CR67","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1016\/s0140-6736(18)30481-1","volume":"391","author":"AJ Thompson","year":"2018","unstructured":"Thompson AJ, Baranzini SE, Geurts J, Hemmer B, Ciccarelli O (2018) Multiple sclerosis. Lancet 391(10130):1622\u20131636. https:\/\/doi.org\/10.1016\/s0140-6736(18)30481-1","journal-title":"Lancet"},{"issue":"2","key":"5764_CR68","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","volume":"84","author":"NJ van Eck","year":"2010","unstructured":"van Eck NJ, Waltman L (2010) Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics 84(2):523\u201338. https:\/\/doi.org\/10.1007\/s11192-009-0146-3","journal-title":"Scientometrics"},{"issue":"10","key":"5764_CR69","doi-asserted-by":"publisher","first-page":"721","DOI":"10.7164\/antibiotics.28.721","volume":"28","author":"C V\u00e9zina","year":"1975","unstructured":"V\u00e9zina C, Kudelski A, Sehgal SN (1975) Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot (Tokyo) 28(10):721\u20136. https:\/\/doi.org\/10.7164\/antibiotics.28.721","journal-title":"J Antibiot (Tokyo)"},{"issue":"12","key":"5764_CR70","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1124\/dmd.104.000885","volume":"32","author":"T Walle","year":"2004","unstructured":"Walle T, Hsieh F, DeLegge MH, Oatis JE Jr., Walle UK (2004) High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 32(12):1377\u201382. https:\/\/doi.org\/10.1124\/dmd.104.000885","journal-title":"Drug Metab Dispos"},{"key":"5764_CR71","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114473","volume":"161","author":"X Wang","year":"2023","unstructured":"Wang X, Jia J (2023) Magnolol improves Alzheimer\u2019s disease-like pathologies and cognitive decline by promoting autophagy through activation of the AMPK\/mTOR\/ULK1 pathway. Biomed Pharmacother 161:114473. https:\/\/doi.org\/10.1016\/j.biopha.2023.114473","journal-title":"Biomed Pharmacother"},{"key":"5764_CR72","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.1014251","volume":"15","author":"Q Wang","year":"2022","unstructured":"Wang Q, Xue H, Yue Y, Hao S, Huang SH, Zhang Z (2022) Role of mitophagy in the neurodegenerative diseases and its pharmacological advances: a review. Front Mol Neurosci 15:1014251. https:\/\/doi.org\/10.3389\/fnmol.2022.1014251","journal-title":"Front Mol Neurosci"},{"issue":"7","key":"5764_CR73","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/nn.2575","volume":"13","author":"E Wong","year":"2010","unstructured":"Wong E, Cuervo AM (2010) Autophagy gone awry in neurodegenerative diseases. Nat Neurosci 13(7):805\u2013811. https:\/\/doi.org\/10.1038\/nn.2575","journal-title":"Nat Neurosci"},{"issue":"1","key":"5764_CR74","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/tra.12620","volume":"20","author":"XC Yao","year":"2019","unstructured":"Yao XC, Xue X, Zhang HT, Zhu MM, Yang XW, Wu CF et al (2019) Pseudoginsenoside-F11 alleviates oligomeric \u03b2-amyloid-induced endosome-lysosome defects in microglia. Traffic 20(1):61\u201370. https:\/\/doi.org\/10.1111\/tra.12620","journal-title":"Traffic"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05764-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05764-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05764-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:04:29Z","timestamp":1785765869000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05764-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,3]]},"references-count":74,"alternative-id":["5764"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05764-1","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,3]]},"assertion":[{"value":"8 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors confirm that the bibliometric analyses reported in this manuscript were performed by the authors and that no paper mill was used.","order":5,"name":"Ethics","label":"Research integrity statement","group":{"name":"EthicsHeading","label":"Declarations"}}]}}