{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:37:16Z","timestamp":1786628236915,"version":"build-2736575974"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"DOI":"10.1007\/s00210-026-05795-8","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:56:13Z","timestamp":1786582573000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of colostrum-coated ZnO nanoparticles (C-ZnONPs) in attenuating valproic acid-induced prenatal toxicity"],"prefix":"10.1007","author":[{"given":"Kuljeet","family":"Kaur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajneesh","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0099-5231","authenticated-orcid":false,"given":"Niladry Sekhar","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"issue":"11","key":"5795_CR1","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.3390\/pharmaceutics13111937","volume":"13","author":"S Abdulmalek","year":"2021","unstructured":"Abdulmalek S, Nasef M, Awad D, Balbaa M (2021) Protective effect of natural antioxidant, curcumin nanoparticles, and zinc oxide nanoparticles against type 2 diabetes-promoted hippocampal neurotoxicity in rats. Pharmaceutics 13(11):1937. https:\/\/doi.org\/10.3390\/pharmaceutics13111937","journal-title":"Pharmaceutics"},{"issue":"14","key":"5795_CR2","doi-asserted-by":"publisher","first-page":"1269581","DOI":"10.3389\/fphar.2023.1269581","volume":"18","author":"S Afzal","year":"2023","unstructured":"Afzal S, Abdul Manap AS, Attiq A, Albokhadaim I, Kandeel M, Alhojaily SM (2023) From imbalance to impairment: the central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration. Front Pharmacol 18(14):1269581. https:\/\/doi.org\/10.3389\/fphar.2023.1269581","journal-title":"Front Pharmacol"},{"key":"5795_CR3","doi-asserted-by":"publisher","unstructured":"Asokan S, Jacob T, Atiyah MM et al (2026) Bacteria mediated green synthesis of zinc oxide nanoparticles: a sustainable nanotechnology approach for biomedical applications. Biomed Mater Devices. https:\/\/doi.org\/10.1007\/s44174-025-00578-w","DOI":"10.1007\/s44174-025-00578-w"},{"issue":"16","key":"5795_CR4","doi-asserted-by":"publisher","first-page":"1608269","DOI":"10.3389\/fimmu.2025.1608269","volume":"12","author":"VA Badaluta","year":"2025","unstructured":"Badaluta VA, Ionascu A, Ditu LM, Curutiu C, Holban AM, Oprea E, Kourkoutas Y, Mihai MM, Cucu CI, Hudita A, Marinescu F, Lazar V (2025) Antimicrobial and immunomodulatory activity of natural bioactive compounds - an in vitro investigation with potential applications in managing Hidradenitis Suppurativa. Front Immunol 12(16):1608269. https:\/\/doi.org\/10.3389\/fimmu.2025.1608269","journal-title":"Front Immunol"},{"key":"5795_CR5","doi-asserted-by":"crossref","unstructured":"Boostanifard M, Moradi HR, Abbasi S, Khaksar Z (2026b) Lactational exposure to polystyrene nanoplastics is associated with dose-related ovarian alterations in rat offspring. Environ Sci Pollut Res 33(19):9732\u20139747","DOI":"10.1007\/s11356-026-37923-5"},{"key":"5795_CR6","doi-asserted-by":"publisher","unstructured":"Bostanifard M, Moradi HR, Khaksar Z, Abbasi S, Hadavand BS, Faraji M (2026a) Transplacental and lactational transfer of polystyrene nanoplastics leads to long-term ovarian impairment in rat offspring. Journal of Hazardous Materials Advances. https:\/\/doi.org\/10.1016\/j.hazadv.2026.101007","DOI":"10.1016\/j.hazadv.2026.101007"},{"issue":"15","key":"5795_CR7","doi-asserted-by":"publisher","first-page":"4569","DOI":"10.3390\/molecules26154569","volume":"26","author":"A Brizzolari","year":"2021","unstructured":"Brizzolari A, Dei Cas M, Cialoni D, Marroni A, Morano C, Samaja M, Paroni R, Rubino FM (2021) High-throughput griess assay of nitrite and nitrate in plasma and red blood cells for human physiology studies under extreme conditions. Molecules 26(15):4569. https:\/\/doi.org\/10.3390\/molecules26154569","journal-title":"Molecules"},{"issue":"4","key":"5795_CR8","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.2471","volume":"117","author":"LTL Brown","year":"2025","unstructured":"Brown LTL, Pereira D, Winn LM (2025) A narrative review on the effect of valproic acid on the placenta. Birth Defects Res 117(4):e2471. https:\/\/doi.org\/10.1002\/bdr2.2471","journal-title":"Birth Defects Res"},{"issue":"24","key":"5795_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/nu16244305","volume":"16","author":"AA Canbolat","year":"2024","unstructured":"Canbolat AA, Lombardo M, Mondragon ADC, Miranda L\u00f3pez JM, Bechelany M, Karav S (2024) Bovine colostrum in pediatric nutrition and health. Nutrients 16(24):4305. https:\/\/doi.org\/10.3390\/nu16244305","journal-title":"Nutrients"},{"issue":"5","key":"5795_CR10","doi-asserted-by":"publisher","first-page":"4822","DOI":"10.3390\/ijms24054822","volume":"24","author":"MI Costa","year":"2023","unstructured":"Costa MI, Sarmento-Ribeiro AB, Gon\u00e7alves AC (2023) Zinc: from biological functions to therapeutic potential. Int J Mol Sci 24(5):4822. https:\/\/doi.org\/10.3390\/ijms24054822","journal-title":"Int J Mol Sci"},{"issue":"2","key":"5795_CR11","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1021\/tx0502241","volume":"19","author":"D Eikel","year":"2006","unstructured":"Eikel D, Lampen A, Nau H (2006) Teratogenic effects mediated by inhibition of histone deacetylases: evidence from quantitative structure activity relationships of 20 valproic acid derivatives. Chem Res Toxicol 19(2):272\u2013278","journal-title":"Chem Res Toxicol"},{"key":"5795_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.smallrumres.2021.106348","volume":"198","author":"F E\u015fki","year":"2021","unstructured":"E\u015fki F, Kurt S, Demir PA (2021) Effect of different estrus synchronization protocols on estrus and pregnancy rates, oxidative stress and some biochemical parameters in Hair goats. Small Rumin Res 198:106348","journal-title":"Small Rumin Res"},{"issue":"1","key":"5795_CR13","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/s00580-026-03819-6","volume":"35","author":"F Esmaeili","year":"2026","unstructured":"Esmaeili F, Moradi HR, Kazemipour N, Abdinasab MH, Faraji M, Nazifi S (2026) Protective effects of sitagliptin against cyclophosphamide-induced hepatorenal toxicity in rats: biochemical, histological, and immunohistochemical evaluation. Comp Clin Pathol 35(1):82","journal-title":"Comp Clin Pathol"},{"key":"5795_CR14","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s11940-024-00798-3","volume":"26","author":"C Espinosa-Jovel","year":"2024","unstructured":"Espinosa-Jovel C, Valencia N (2024) The current role of valproic acid in the treatment of epilepsy: a glimpse into the present of an old ally. Curr Treat Options Neurol 26:393\u2013410. https:\/\/doi.org\/10.1007\/s11940-024-00798-3","journal-title":"Curr Treat Options Neurol"},{"issue":"5","key":"5795_CR15","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1111\/epi.18281","volume":"66","author":"R Esposto","year":"2025","unstructured":"Esposto R, Falcicchio G, Zambrelli E, Cerulli Irelli E, Monti G, Ranzato F, Giuliano L, La Neve A, Galimberti CA, Belotti LMB, Turner K, Catania C, Polo D, Todaro V, Bisulli F, Mostacci B (2025) Valproate discontinuation in girls and women of childbearing age with epilepsy: an Italian multicenter retrospective study on prescribing patterns and outcomes. Epilepsia 66(5):1529\u20131539. https:\/\/doi.org\/10.1111\/epi.18281","journal-title":"Epilepsia"},{"key":"5795_CR16","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1002\/ame2.70017","volume":"8","author":"M Faraji","year":"2025","unstructured":"Faraji M, Noorbakhsh MF, Kazemipour N, Nazifi S, Moradi HR, Ahmadi N, Azadmanesh M (2025) Comparison of the effects of metformin, citral, Cymbopogon citratus extract and silver nanoparticles of Cymbopogon citratus extract on oxidative stress indices and Nrf2 levels in experimental type 2 diabetes in rats. Anim Models Exp Med 8:2128\u20132138. https:\/\/doi.org\/10.1002\/ame2.70017","journal-title":"Anim Models Exp Med"},{"key":"5795_CR17","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3389\/fnbeh.2013.00088","volume":"7","author":"MR Favre","year":"2013","unstructured":"Favre MR, Barkat TR, LaMendola D, Khazen G, Markram H, Markram K (2013) General developmental health in the VPA-rat model of autism. Front Behav Neurosci 7:88. https:\/\/doi.org\/10.3389\/fnbeh.2013.00088","journal-title":"Front Behav Neurosci"},{"key":"5795_CR18","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.1007\/s44174-025-00412-3","volume":"4","author":"M Gomathi","year":"2026","unstructured":"Gomathi M, Kirubakaran D, Malarkodi R (2026) Synthesis, characterization and biomedical environmental applications of magnesium-doped zinc oxide nanoparticles using Laggera alata extract. Biomed Mater Devices 4:2606\u20132624. https:\/\/doi.org\/10.1007\/s44174-025-00412-3","journal-title":"Biomed Mater Devices"},{"key":"5795_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/s42269-024-01189-z","volume":"48","author":"MH Hadwan","year":"2024","unstructured":"Hadwan MH, Alta\u2019ee AH, Mohammed RM et al (2024) An efficient protocol for quantifying catalase activity in biological samples. Bull Natl Res Cent 48:34. https:\/\/doi.org\/10.1186\/s42269-024-01189-z","journal-title":"Bull Natl Res Cent"},{"issue":"1","key":"5795_CR20","doi-asserted-by":"publisher","DOI":"10.1093\/biomethods\/bpae015","volume":"9","author":"MH Hadwan","year":"2024","unstructured":"Hadwan MH, Hussein MJ, Mohammed RM, Hadwan AM, Saad Al-Kawaz H, Al-Obaidy SS, Al Talebi ZA (2024) An improved method for measuring catalase activity in biological samples. Biology Methods and Protocols 9(1):bpae015","journal-title":"Biology Methods and Protocols"},{"issue":"10","key":"5795_CR21","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1177\/0960327120921441","volume":"39","author":"A Hussain","year":"2020","unstructured":"Hussain A, Kumar S, Kaul G (2020) Postnatal distribution of ZnO nanoparticles to the breast milk through oral route and their risk assessment for breastfed rat offsprings. Hum Exp Toxicol 39(10):1332. https:\/\/doi.org\/10.1177\/0960327120921441","journal-title":"Hum Exp Toxicol"},{"key":"5795_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2024.108551","volume":"124","author":"BL Jackson","year":"2024","unstructured":"Jackson BL, Shafique S, Natale BV, Natale DRC, Winn LM (2024) Investigating the effects of valproic acid on placental epigenetic modifications and development in the CD-1 mouse model. Reprod Toxicol 124:108551. https:\/\/doi.org\/10.1016\/j.reprotox.2024.108551","journal-title":"Reprod Toxicol"},{"issue":"4","key":"5795_CR23","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1111\/1541-4337.12067","volume":"13","author":"K Kaur","year":"2014","unstructured":"Kaur K, Gupta R, Saraf SA, Saraf SK (2014) Zinc: The Metal of Life. Compr Rev Food Sci Food Saf 13(4):358\u2013376. https:\/\/doi.org\/10.1111\/1541-4337.12067","journal-title":"Compr Rev Food Sci Food Saf"},{"issue":"10","key":"5795_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.70395","volume":"39","author":"K Kaur","year":"2025","unstructured":"Kaur K, Gupta R, Verma N, Ghosh NS, Singh R (2025) Eco-friendly ZnO nanoparticle synthesis and colostrum coating: structural insights and biomedical potential. Appl Organomet Chem 39(10):e70395","journal-title":"Appl Organomet Chem"},{"key":"5795_CR25","doi-asserted-by":"publisher","first-page":"hzt003","DOI":"10.1093\/biohorizons\/hzt003","volume":"6","author":"KA Lloyd","year":"2013","unstructured":"Lloyd KA (2013) A scientific review: mechanisms of valproate-mediated teratogenesis. Biosci Horiz 6:hzt003. https:\/\/doi.org\/10.1093\/biohorizons\/hzt003","journal-title":"Biosci Horiz"},{"issue":"1","key":"5795_CR26","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s12884-018-1842-x","volume":"18","author":"A Macfarlane","year":"2018","unstructured":"Macfarlane A, Greenhalgh T (2018) Sodium valproate in pregnancy: what are the risks and should we use a shared decision-making approach? BMC Pregnancy Childbirth 18(1):200. https:\/\/doi.org\/10.1186\/s12884-018-1842-x","journal-title":"BMC Pregnancy Childbirth"},{"issue":"11","key":"5795_CR27","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1097\/01.fpc.0000170914.11898.3a","volume":"15","author":"V Massa","year":"2005","unstructured":"Massa V, Cabrera RM, Menegola E, Giavini E, Finnell RHc (2005) Valproic acid-induced skeletal malformations: associated gene expression cascades. Pharmacogenet Genomics 15(11):787\u2013800. https:\/\/doi.org\/10.1097\/01.fpc.0000170914.11898.3a","journal-title":"Pharmacogenet Genomics"},{"key":"5795_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntm.2025.100097","author":"AM Mohammed","year":"2025","unstructured":"Mohammed AM, Mohammed M, Oleiwi JK, Ihmedee FH, Adam T, Betar BO, Gopinath SC (2025) The anticancer, antioxidant, and antimicrobial properties of zinc oxide nanoparticles: a comprehensive review. Nano TransMed. https:\/\/doi.org\/10.1016\/j.ntm.2025.100097","journal-title":"Nano TransMed"},{"issue":"3","key":"5795_CR29","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s10735-025-10414-6","volume":"56","author":"HR Moradi","year":"2025","unstructured":"Moradi HR, Kazemipour N, Nazifi S, Khodayari M, Samadi L, Yousefi A (2025) Protective effects of wheat sprout extract on acrylamide-induced toxicity in testis, prostate gland and sperm parameters of rats. J Mol Histol 56(3):137. https:\/\/doi.org\/10.1007\/s10735-025-10414-6","journal-title":"J Mol Histol"},{"issue":"1","key":"5795_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/plants15010147","volume":"15","author":"EH Ochoa-Chaparro","year":"2026","unstructured":"Ochoa-Chaparro EH, Castruita-Esparza LU, S\u00e1nchez E (2026) Eco-physiological and molecular roles of zinc oxide nanoparticles (ZnO-NPs) in mitigating abiotic stress: a comprehensive review. Plants (Basel) 15(1):147. https:\/\/doi.org\/10.3390\/plants15010147","journal-title":"Plants (Basel)"},{"issue":"1","key":"5795_CR31","doi-asserted-by":"publisher","first-page":"390","DOI":"10.3390\/ijms25010390","volume":"25","author":"A Ornoy","year":"2023","unstructured":"Ornoy A, Echefu B, Becker M (2023) Valproic Acid in Pregnancy Revisited: Neurobehavioral, Biochemical and Molecular Changes Affecting the Embryo and Fetus in Humans and in Animals: A Narrative Review. Int J Mol Sci 25(1):390. https:\/\/doi.org\/10.3390\/ijms25010390","journal-title":"Int J Mol Sci"},{"issue":"10","key":"5795_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103721","volume":"21","author":"A Ornoy","year":"2020","unstructured":"Ornoy A, Becker M, Weinstein-Fudim L, Ergaz Z (2020) S-Adenosine methionine (SAMe) and valproic acid (VPA) as epigenetic modulators: special emphasis on their interactions affecting nervous tissue during pregnancy. Int J Mol Sci 21(10):3721","journal-title":"Int J Mol Sci"},{"issue":"18","key":"5795_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/nu15184041","volume":"15","author":"L Page","year":"2023","unstructured":"Page L, Younge N, Freemark M (2023) Hormonal determinants of growth and weight gain in the human fetus and preterm infant. Nutrients 15(18):4041","journal-title":"Nutrients"},{"issue":"1","key":"5795_CR34","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/medicina62010021","volume":"62","author":"CD Pavel","year":"2026","unstructured":"Pavel CD, Chi\u0163escu CL, Dragostin OM, Dediu L, Aprodu I, Iacob AD et al (2026) Evaluation of oxidative stress and antioxidant effects of methylxanthines in adult zebrafish exposed to zinc oxide nanoparticles (ZnO-NPs). Medicina (Kaunas) 62(1):21. https:\/\/doi.org\/10.3390\/medicina62010021","journal-title":"Medicina (Kaunas)"},{"issue":"1","key":"5795_CR35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-52217-x","volume":"14","author":"P Perumal","year":"2024","unstructured":"Perumal P, Sathakkathulla NA, Kumaran K, Ravikumar R, Selvaraj JJ, Nagendran V, Gurusamy M et al (2024) Green synthesis of zinc oxide nanoparticles using aqueous extract of shilajit and their anticancer activity against HeLa cells. Sci Rep 14(1):2204","journal-title":"Sci Rep"},{"issue":"8","key":"5795_CR36","doi-asserted-by":"publisher","first-page":"4226","DOI":"10.1021\/es4052999","volume":"48","author":"EJ Petersen","year":"2014","unstructured":"Petersen EJ, Henry TB, Zhao J, MacCuspie RI, Kirschling TL, Dobrovolskaia MA et al (2014) Identification and avoidance of potential artifacts and misinterpretations in nanomaterial ecotoxicity measurements. Environ Sci Technol 48(8):4226\u20134246. https:\/\/doi.org\/10.1021\/es4052999","journal-title":"Environ Sci Technol"},{"issue":"11","key":"5795_CR37","doi-asserted-by":"publisher","DOI":"10.3390\/nu15112490","volume":"15","author":"B Piknova","year":"2023","unstructured":"Piknova B, Park JW, Thomas SM, Tunau-Spencer KJ, Schechter AN (2023) Nitrate and nitrite metabolism in aging rats: a comparative study. Nutrients 15(11):2490. https:\/\/doi.org\/10.3390\/nu15112490","journal-title":"Nutrients"},{"key":"5795_CR38","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s13205-021-02879-5","volume":"11","author":"YL Rao","year":"2021","unstructured":"Rao YL, Ganaraja B, Marathe A et al (2021) Comparison of malondialdehyde levels and superoxide dismutase activity in resveratrol and resveratrol\/donepezil combination treatment groups in Alzheimer\u2019s disease induced rat model. 3 Biotech 11:329. https:\/\/doi.org\/10.1007\/s13205-021-02879-5","journal-title":"3 Biotech"},{"issue":"09","key":"5795_CR39","doi-asserted-by":"publisher","first-page":"303","DOI":"10.4236\/ajac.2024.159020","volume":"15","author":"M Rizzo","year":"2024","unstructured":"Rizzo M (2024) Measurement of malondialdehyde as a biomarker of lipid oxidation in fish. Am J Anal Chem 15(09):303\u2013332","journal-title":"Am J Anal Chem"},{"key":"5795_CR40","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-026-46793-3","author":"Z Sabzi","year":"2026","unstructured":"Sabzi Z, Mohajeri Amiri M, Sadat Shandiz SA (2026) Biosynthesis of CuO-ZnO nanoparticles using Levilactobacillus brevis: implication in antibacterial, antioxidant, and anticancer activities. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-026-46793-3","journal-title":"Sci Rep"},{"key":"5795_CR41","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1007\/s44174-025-00373-7","volume":"4","author":"A Shanmugarathinam","year":"2026","unstructured":"Shanmugarathinam A, Elamaran N, Kirubakaran D et al (2026) Sustainable synthesis of zinc oxide nanoparticles from Vicoa indica leaf extract: characterization and evaluation of antibacterial, antioxidant, and anticancer properties. Biomed Mater Devices 4:1036\u20131051. https:\/\/doi.org\/10.1007\/s44174-025-00373-7","journal-title":"Biomed Mater Devices"},{"key":"5795_CR42","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.lfs.2015.03.014","volume":"130","author":"S Sobo\u010danec","year":"2015","unstructured":"Sobo\u010danec S, \u0160ari\u0107 A, \u0160afranko \u017dM, Had\u017eija MP, Abrami\u0107 M, Balog T (2015) The role of 17\u03b2-estradiol in the regulation of antioxidant enzymes via the Nrf2\u2013Keap1 pathway in the livers of CBA\/H mice. Life Sci 130:57\u201365","journal-title":"Life Sci"},{"key":"5795_CR43","doi-asserted-by":"publisher","unstructured":"Tipple TE, Rogers LK (2012) Methods for the determination of plasma or tissue glutathione levels. In: Harris C, Hansen J (eds) Developmental toxicology. Methods in molecular biology, vol 889. Humana Press, Totowa, NJ. https:\/\/doi.org\/10.1007\/978-1-61779-867-2_20","DOI":"10.1007\/978-1-61779-867-2_20"},{"issue":"6","key":"5795_CR44","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1124\/mol.111.071456","volume":"80","author":"EW Tung","year":"2011","unstructured":"Tung EW, Winn LM (2011) Valproic acid increases formation of reactive oxygen species and induces apoptosis in postimplantation embryos: a role for oxidative stress in valproic acid-induced neural tube defects. Mol Pharmacol 80(6):979\u2013987. https:\/\/doi.org\/10.1124\/mol.111.071456","journal-title":"Mol Pharmacol"},{"issue":"37","key":"5795_CR45","doi-asserted-by":"publisher","first-page":"8292","DOI":"10.1021\/acs.jafc.5b03372","volume":"63","author":"X Yan","year":"2015","unstructured":"Yan X, Rong R, Zhu S, Guo M, Gao S, Wang S et al (2015) Effects of ZnO nanoparticles on dimethoate-induced toxicity in mice. J Agric Food Chem 63(37):8292\u20138298. https:\/\/doi.org\/10.1021\/acs.jafc.5b03372","journal-title":"J Agric Food Chem"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05795-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05795-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05795-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:02:14Z","timestamp":1786626134000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05795-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":45,"alternative-id":["5795"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05795-8","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]},"assertion":[{"value":"8 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}}]}}