{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:15:06Z","timestamp":1792091706083,"version":"4.4.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005279","name":"Universidade Federal Do Piau\u00ed","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005279","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Organotellurium (OTe) compounds have pharmacological properties, including leishmanicidal, antimalarial, and antifungal activities. Herein, we assessed cytotoxicity effects of OTe RF07 in a panel of tumor cell lines, as well as its oxidative, toxicity, and hemolytic actions. The toxicity was evaluated on\n                    <jats:italic>Allium cepa<\/jats:italic>\n                    and\n                    <jats:italic>Artemia salina<\/jats:italic>\n                    larvae. Cell viability was also assessed by resazurin in murine cells (Sarcoma 180), human cells (HL-60, leukemia; AGP01, gastric adenocarcinoma; SKMEL-28, human melanoma; MRC-5, normal fibroblasts), and dog erythrocytes. The oxidative capacity of RF07 was evaluated by wild-type and antioxidant-mutated enzyme strains of\n                    <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n                    . RF07 presented cytotoxic action on all normal and tumor cells, whose IC\n                    <jats:sub>50<\/jats:sub>\n                    ranged from 0.07\u00a0\u03bcg\/mL (HL-60) to 73.45\u00a0\u03bcg\/mL (Sarcoma 180) and toxicological activity on\n                    <jats:italic>A. salina<\/jats:italic>\n                    nauplii in a concentration-dependent manner after exposure for 24\u00a0h and 48\u00a0h (LC\n                    <jats:sub>50<\/jats:sub>\n                    values of 15.02 and 5.43\u00a0\u03bcg\/mL for 24\u00a0h and 48\u00a0h, respectively). Moreover, RF07 reduced mitotic index of meristematic\n                    <jats:italic>A. cepa<\/jats:italic>\n                    cells at 5, 10 and 20\u00a0\u03bcg\/mL, caused arrest in interphase, and increased chromosomal changes, including micronucleus,\n                    <jats:italic>c<\/jats:italic>\n                    -metaphases, and chromosomal bridges, loss, and delays. In summary, RF07 exhibits antiproliferative action on animal cells, high toxicity on\n                    <jats:italic>Artemia salina<\/jats:italic>\n                    nauplii, as well as clastogenic effects on growing roots. This antimitotic action is not related to direct membrane damage, although it relies on chromosomal injuries and may be related to the induction of oxidative stress as observed in yeast cells.\n                  <\/jats:p>","DOI":"10.1007\/s00210-026-05814-8","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:35:16Z","timestamp":1787790916000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A mechanistic approach about oxidative, mutagenic, and cytotoxic effects of an organotellurane"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2227-9942","authenticated-orcid":false,"given":"Felipe Emannuel Alvino","family":"de Jesus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8932-4295","authenticated-orcid":false,"given":"Oct\u00e1vio Augusto","family":"de Carvalho Maia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0712-9910","authenticated-orcid":false,"given":"Antonielly Campinho","family":"dos Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0408-6860","authenticated-orcid":false,"given":"Audinei","family":"de Sousa Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9778-3667","authenticated-orcid":false,"given":"Anderson Nogueira","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9825-6304","authenticated-orcid":false,"given":"Glissia Lysandra","family":"dos Santos Marciel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0302-5393","authenticated-orcid":false,"given":"Jefferson","family":"da Cruz Esteves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0482-4376","authenticated-orcid":false,"given":"Shamya Gabriella Corr\u00eaa","family":"Co\u00ealho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9941-5529","authenticated-orcid":false,"given":"Isabela Ribeiro","family":"de S\u00e1 Guimar\u00e3es Nol\u00eato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2242-3392","authenticated-orcid":false,"given":"Maria Lu\u00edsa Lima","family":"Barreto do Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6880-0683","authenticated-orcid":false,"given":"Adriana Maria Viana","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1171-8013","authenticated-orcid":false,"given":"D\u00e9bora Caroline","family":"do Nascimento Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0203-3143","authenticated-orcid":false,"given":"Rodrigo Luiz Oliveira","family":"Rodrigues Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5431-6818","authenticated-orcid":false,"given":"Pedro Marcos","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4370-0803","authenticated-orcid":false,"given":"Dalton","family":"Dittz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6862-6497","authenticated-orcid":false,"given":"Paulo Michel Pinheiro","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5085-1482","authenticated-orcid":false,"given":"Jo\u00e3o Marcelo","family":"de Castro e Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"5814_CR1","doi-asserted-by":"publisher","unstructured":"Abondanza TS, Oliveira CR, Barbosa CMV, Pereira FEG, Cunha RLOR, Caires ACF, et al. (2008) Bcl-2 expression and apoptosis induction in human HL60 leukaemic cells treated with a novel organotellurium(IV) compound RT-04. Food Chem Toxicol 46:2540\u20132545. https:\/\/doi.org\/10.1016\/j.fct.2008.04.010","DOI":"10.1016\/j.fct.2008.04.010"},{"key":"5814_CR2","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1039\/c3mt00108c","volume":"5","author":"Y Anan","year":"2013","unstructured":"Anan Y, Yoshida M, Hasegawa S, Katai R, Tokumoto M, Ouerdane L et al (2013) Speciation and identification of tellurium-containing metabolites in garlic, Allium sativum. Metallomics 5:1215\u20131224. https:\/\/doi.org\/10.1039\/c3mt00108c","journal-title":"Metallomics"},{"key":"5814_CR3","doi-asserted-by":"publisher","DOI":"10.1007\/s44339-024-00002-w","volume":"1","author":"DA Animasaun","year":"2024","unstructured":"Animasaun DA, Adedibu PA, Afolabi SO, Abdulkareem KA, Ibrahim S, Krishnamurthy R (2024) Hazard assessment and cytogenotoxic effect of different concentrations of mercury chloride sterilant using the Allium cepa assay. Discover Toxicology 1:Article 2. https:\/\/doi.org\/10.1007\/s44339-024-00002-w","journal-title":"Discover Toxicology"},{"key":"5814_CR4","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.molstruc.2017.04.026","volume":"1142","author":"EJF Ara\u00fajo","year":"2017","unstructured":"Ara\u00fajo EJF, Silva OA, Rezende Junior LM, Sousa IJO, Araujo DYML, Carvalho RBF, Pereira ST, Gutierrez SJC, Ferreira PMP, Lima FCA (2017) Synthesis, characterization and cytotoxic evaluation of inclusion complexes between Riparin A and \u03b2-cyclodextrin. J Mol Struct 1142:84\u201391. https:\/\/doi.org\/10.1016\/j.molstruc.2017.04.026","journal-title":"J Mol Struct"},{"key":"5814_CR5","doi-asserted-by":"publisher","first-page":"4203","DOI":"10.1039\/C0OB00086H","volume":"8","author":"LA Ba","year":"2010","unstructured":"Ba LA, D\u00f6ring M, Jamier V, Jacob C (2010) Tellurium: an element with great biological potency and potential. Org Biomol Chem 8:4203\u20134216. https:\/\/doi.org\/10.1039\/C0OB00086H","journal-title":"Org Biomol Chem"},{"key":"5814_CR6","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jes.2015.03.034","volume":"36","author":"J Bianchi","year":"2015","unstructured":"Bianchi J, Mantovani MS, Marin-Morales MA (2015) Analysis of the genotoxic potential of low concentrations of Malathion on the Allium cepa cells and rat hepatoma tissue culture. J Environ Sci (China) 36:102\u2013111. https:\/\/doi.org\/10.1016\/j.jes.2015.03.034","journal-title":"J Environ Sci (China)"},{"key":"5814_CR7","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1590\/0001-3765201620150553","volume":"88","author":"FRS Carvalho","year":"2016","unstructured":"Carvalho FRS, Moura AG, Rodrigues GF, Nunes NMF, Lima DJB, Pessoa C, Costa MP, Ferreira PMP, Peron AP (2016) Are salty liquid food flavorings in vitro antitumor substances? An Acad Bras Cienc 88:1419\u20131430. https:\/\/doi.org\/10.1590\/0001-3765201620150553","journal-title":"An Acad Bras Cienc"},{"issue":"3\u20134","key":"5814_CR8","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/0165-7992(88)90058-9","volume":"208","author":"I Ceccherini","year":"1988","unstructured":"Ceccherini I, Sbrana I, Loprieno N (1988) Kinetics of chromosomal aberrations and first mitosis division in human lymphocytes exposed to mitomycin C. Mutat Res Lett 208(3\u20134):183\u2013188. https:\/\/doi.org\/10.1016\/0165-7992(88)90058-9","journal-title":"Mutat Res Lett"},{"key":"5814_CR9","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1590\/S0001-37652009000300006","volume":"81","author":"RLOR Cunha","year":"2009","unstructured":"Cunha RLOR, Gouvea IE, Juliano L (2009) A glimpse on biological activities of tellurium compounds. An Acad Bras Cienc 81:393\u2013407. https:\/\/doi.org\/10.1590\/S0001-37652009000300006","journal-title":"An Acad Bras Cienc"},{"issue":"3","key":"5814_CR10","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202501235","volume":"23","author":"FEA De Jesus","year":"2026","unstructured":"De Jesus FEA et al (2026) Cytotoxic, genotoxic, and mutagenic effects of organotellurane RF07 in female Swiss mice (Mus musculus). Chem Biodivers 23(3):e01235","journal-title":"Chem Biodivers"},{"issue":"2","key":"5814_CR11","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3390\/jox15020035","volume":"15","author":"G Duta-Cornescu","year":"2025","unstructured":"Duta-Cornescu G, Dugala ML, Constantin N, Pojoga M-D, Simon-Gruita A (2025) Evaluation of clastogenic and aneugenic action of two bio-insecticides using allium bioassay. J Xenobiotics 15(2):35. https:\/\/doi.org\/10.3390\/jox15020035","journal-title":"J Xenobiotics"},{"key":"5814_CR12","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.parint.2015.09.006","volume":"65","author":"S El Chamy Maluf","year":"2016","unstructured":"El Chamy Maluf S, Melo PMS, Varotti FP, Gazarini ML, Cunha RLOR, Carmona AK (2016) Hypervalent organotellurium compounds as inhibitors of P. falciparum calcium-dependent cysteine proteases. Parasitol Int 65:20\u201322. https:\/\/doi.org\/10.1016\/j.parint.2015.09.006","journal-title":"Parasitol Int"},{"issue":"3","key":"5814_CR13","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1590\/S0001-37652011005000017","volume":"83","author":"PMP Ferreira","year":"2011","unstructured":"Ferreira PMP, Farias DF, Viana MP, Souza TM, Vasconcelos IM, Soares BM, Pessoa C, Costa-Lotufo LV, Moraes MO, Carvalho AFFU (2011) Study of the antiproliferative potential ofseed extracts from Northeastern Brazilian plants. Anais da Academia Brasileira de Ci\u00eancias 83(3):1045\u20131058. https:\/\/doi.org\/10.1590\/S0001-37652011005000017","journal-title":"Anais da Academia Brasileira de Ci\u00eancias"},{"key":"5814_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2019.114692","volume":"380","author":"PMP Ferreira","year":"2019","unstructured":"Ferreira PMP, Machado KC, Lavorato SN, Oliveira FCE, Silva JN, Almeida AAC, Santos LS, Silva VR, Bezerra DP, Soares MBP, Pessoa C, Moraes Filho MO, Ferreira JRO, Sousa JMC, Maltarollo VG, Alves RJ (2019) Pharmacological and physicochemical profile of arylacetamides as tools against human cancers. Toxicol Appl Pharmacol 380:114692. https:\/\/doi.org\/10.1016\/j.taap.2019.114692","journal-title":"Toxicol Appl Pharmacol"},{"key":"5814_CR15","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/j.1601-5223.1985.tb00471.x","volume":"102","author":"G Fiskesj\u00f6","year":"1985","unstructured":"Fiskesj\u00f6 G (1985) The Allium test as a standard in environmental monitoring. Hereditas 102:99\u2013112. https:\/\/doi.org\/10.1111\/j.1601-5223.1985.tb00471.x","journal-title":"Hereditas"},{"key":"5814_CR16","doi-asserted-by":"publisher","unstructured":"Friedman M, Bayer I, Letko I, Duvdevani R, Zavaro-Levy O, Ron B, et al. (2009) Topical treatment for human papillomavirus-associated genital warts in humans with the novel tellurium immunomodulator AS101: assessment of its safety and efficacy. Br J Dermatol 160:403\u2013408. https:\/\/doi.org\/10.1111\/j.1365-2133.2008.08853.x","DOI":"10.1111\/j.1365-2133.2008.08853.x"},{"key":"5814_CR17","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1021\/es60130a004","volume":"12","author":"MA Hamilton","year":"1977","unstructured":"Hamilton MA, Russo RC, Thurston RV (1977) Trimmed Spearman-Karber method for estimating median lethal concentrations in toxicity bioassays. Environ Sci Technol 12:714\u2013719. https:\/\/doi.org\/10.1021\/es60130a004","journal-title":"Environ Sci Technol"},{"key":"5814_CR18","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.cbi.2008.12.013","volume":"180","author":"W Hassan","year":"2009","unstructured":"Hassan W, Ibrahim M, Nogueira CW, Braga AL, Deobald AM, MohammadZai IU et al (2009) Influence of pH on the reactivity of diphenyl ditelluride with thiols and antioxidant potential in rat brain. Chem Biol Interact 180:47\u201353. https:\/\/doi.org\/10.1016\/j.cbi.2008.12.013","journal-title":"Chem Biol Interact"},{"issue":"12","key":"5814_CR19","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.3390\/plants9121711","volume":"9","author":"M Hasanuzzaman","year":"2020","unstructured":"Hasanuzzaman M, Bhuyan MB, Raza A, Hawrylak-Nowak B, Matraszek-Gawron R, Nahar K, Fujita M (2020) Selenium toxicity in plants and environment: biogeochemistry and remediation possibilities. Plants (Basel) 9(12):1711. https:\/\/doi.org\/10.3390\/plants9121711","journal-title":"Plants (Basel)"},{"key":"5814_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2024.138658","volume":"311","author":"M Kny","year":"2025","unstructured":"Kny M, Strub K, Rider M, Gaida A, R\u00f6hm KH (2025) Developing and optimizing a Saccharomyces cerevisiae-based cytotoxicity bioassay for toxicity assessment of contaminated waters. Chemosphere 311:138658. https:\/\/doi.org\/10.1016\/j.chemosphere.2024.138658","journal-title":"Chemosphere"},{"key":"5814_CR21","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.mrrev.2009.06.002","volume":"682","author":"DM Leme","year":"2009","unstructured":"Leme DM, Marin-Morales MA (2009) Allium cepa test in environmental monitoring: a review on its application. Mutat Res 682:71\u201381. https:\/\/doi.org\/10.1016\/j.mrrev.2009.06.002","journal-title":"Mutat Res"},{"key":"5814_CR22","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.toxlet.2017.12.018","volume":"285","author":"KDC Machado","year":"2018","unstructured":"Machado KDC, Sousa LQ, Lima DJB, Soares BM, Cavalcanti BC, Maranh\u00e3o SS, Noronha JDC, Rodrigues DJ, Milit\u00e3o GCG, Chaves MH, Vieira-J\u00fanior GM, Pessoa C, Moraes MO, Sousa JMCE, Melo-Cavalcante AAC, Ferreira PMP (2018) Marinobufagin, a molecule from poisonous frogs, causes biochemical, morphological and cell cycle changes in human neoplasms and vegetal cells. Toxicol Lett 285:121\u2013131. https:\/\/doi.org\/10.1016\/j.toxlet.2017.12.018","journal-title":"Toxicol Lett"},{"key":"5814_CR23","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1002\/1099-0461(2000)14:63C310::aid-jbt33E3.0.co;2-d","volume":"14","author":"EN Maciel","year":"2000","unstructured":"Maciel EN, Bolzan RC, Braga AL, Rocha JB (2000) Diphenyl diselenide and diphenyl ditelluride differentially affect delta-aminolevulinate dehydratase from liver, kidney, and brain of mice. J Biochem Mol Toxicol 14:310\u2013319. https:\/\/doi.org\/10.1002\/1099-0461(2000)14:6%3C310::aid-jbt3%3E3.0.co;2-d","journal-title":"J Biochem Mol Toxicol"},{"key":"5814_CR24","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.chemosphere.2011.06.056","volume":"85","author":"DEC Mazzeo","year":"2011","unstructured":"Mazzeo DEC, Fernandes TCC, Marin-Morales MA (2011) Cellular damages in the Allium cepa test system, caused by BTEX mixture prior and after biodegradation process. Chemosphere 85:13\u201318. https:\/\/doi.org\/10.1016\/j.chemosphere.2011.06.056","journal-title":"Chemosphere"},{"key":"5814_CR25","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1177\/009286159803200223","volume":"32","author":"JL McLaughlin","year":"1998","unstructured":"McLaughlin JL, Rogers LL, Anderson JE (1998) The use of biological assays to evaluate botanicals. Drug Inf J 32:513\u2013524. https:\/\/doi.org\/10.1177\/009286159803200223","journal-title":"Drug Inf J"},{"key":"5814_CR26","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1055\/s-2007-971236","volume":"45","author":"BN Meyer","year":"1982","unstructured":"Meyer BN, Ferrigni NR, Putnam JE, Jacobsen LB, Nichols DE, McLaughlin JL (1982) Brine shrimp: a convenient general bioassay for active plant constituents. Planta Med 45:31\u201334. https:\/\/doi.org\/10.1055\/s-2007-971236","journal-title":"Planta Med"},{"key":"5814_CR27","doi-asserted-by":"publisher","unstructured":"Nunes NMF, Silva JN, Conceicao MLP, Costa Junior JS, Sousa ES, Oliveira MDA, Cito AMGL, Dittz D, Peron AP, Ferreira PMP (2023) In vitro and in vivo acute toxicity of an artificial butter flavoring. J Toxicol Environ Health A 86:181. https:\/\/doi.org\/10.1080\/15287394.2023.2172502","DOI":"10.1080\/15287394.2023.2172502"},{"key":"5814_CR28","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1080\/01480545.2023.2188440","volume":"47","author":"HA Negreiros","year":"2024","unstructured":"Negreiros HA, Fontele SBC, Batista FA, Farias MG, Silva FCC, Nascimento MLLB, Moura KG, Correa LS, Pereira ARS, Lopes LO, Ferreira PMP, Mendes AN, Goncalves JCR, Melo-Cavalcante AAC, Sousa JMC (2024) Toxicogenetic profile of the monoterpene alpha-terpineol on normal and tumor eukaryotic cells. Drug Chem Toxicol 47:427\u2013435. https:\/\/doi.org\/10.1080\/01480545.2023.2188440","journal-title":"Drug Chem Toxicol"},{"key":"5814_CR29","doi-asserted-by":"publisher","first-page":"6255","DOI":"10.1021\/cr0406559","volume":"104","author":"CW Nogueira","year":"2004","unstructured":"Nogueira CW, Zeni G, Rocha JBT (2004) Organoselenium and organotellurium compounds: toxicology and pharmacology. Chem Rev 104:6255\u20136285. https:\/\/doi.org\/10.1021\/cr0406559","journal-title":"Chem Rev"},{"key":"5814_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/toxics13060442","volume":"13","author":"II Olaru","year":"2025","unstructured":"Olaru II, Olaru OT, Mihai DP, Gird CE, Zanfirescu A, Boscencu RL, Luta EA, Andrei C, Nitulescu GM (2025) A dual bioassay for evaluation of embryotoxicity and acute toxicity of common solvents and surfactants in Artemia salina. Toxics (Basel) 13:442. https:\/\/doi.org\/10.3390\/toxics13060442","journal-title":"Toxics (Basel)"},{"key":"5814_CR31","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1039\/c7mt00022g","volume":"9","author":"Y Ogra","year":"2017","unstructured":"Ogra Y (2017) Biology and toxicology of tellurium explored by speciation analysis. Metallomics 9:435\u2013441. https:\/\/doi.org\/10.1039\/c7mt00022g","journal-title":"Metallomics"},{"key":"5814_CR32","doi-asserted-by":"publisher","unstructured":"Okun E, Arumugam TV, Tang SC, Gleichmann M, Albeck M, Sredni B, et al. (2007) The organotellurium compound ammonium trichloro(dioxoethylene-0,0\u2019) tellurate enhances neuronal survival and improves functional outcome in an ischemic stroke model in mice. J Neurochem.https:\/\/doi.org\/10.1111\/j.1471-4159.2007.04615.x","DOI":"10.1111\/j.1471-4159.2007.04615.x"},{"key":"5814_CR33","doi-asserted-by":"publisher","unstructured":"Oliveira GL da S, Oliveira FR de AM, Alencar MVOB, Junior ALG, Souza AA, Cavalcante AA de CM, et al. (2014) Evaluation of antioxidant capacity of the aqueous extract of Cynara scolymus L. (Asteraceae) in vitro and in Saccharomyces cerevisiae. Afr J Pharm Pharmacol 8:136\u2013147. https:\/\/doi.org\/10.5897\/AJPP2013.3836","DOI":"10.5897\/AJPP2013.3836"},{"issue":"12","key":"5814_CR34","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.1016\/j.bmc.2019.03.032","volume":"27","author":"T Paschoalin","year":"2019","unstructured":"Paschoalin T, Martens AA, Omori AT, Pereira FV, Juliano L, Travassos LR, Machado-Santelli GM, Cunha RL (2019) Antitumor effect of chiral organotelluranes elicited in a murine melanoma model. Bioorg Med Chem 27(12):2537\u20132545. https:\/\/doi.org\/10.1016\/j.bmc.2019.03.032","journal-title":"Bioorg Med Chem"},{"key":"5814_CR35","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.nbd.2008.04.001","volume":"31","author":"DS Persike","year":"2008","unstructured":"Persike DS, Cunha RLOR, Juliano L, Silva IR, Rosim FE, Vignoli T et al (2008) Protective effect of the organotelluroxetane RF-07 in pilocarpine-induced status epilepticus. Neurobiol Dis 31:120\u2013126. https:\/\/doi.org\/10.1016\/j.nbd.2008.04.001","journal-title":"Neurobiol Dis"},{"key":"5814_CR36","doi-asserted-by":"publisher","unstructured":"Pessoto FS, Yokomizo CH, Cunha RLOR, Nantes-Cardoso IL (2021) Cellular feedback to organotelluranes displays modulation of antioxidant proteins gene expression. bioRxiv. https:\/\/doi.org\/10.1101\/2021.01.05.425411","DOI":"10.1101\/2021.01.05.425411"},{"key":"5814_CR37","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1016\/j.bmc.2011.01.054","volume":"19","author":"L Piovan","year":"2011","unstructured":"Piovan L, Alves MFM, Juliano L, Br\u00f6mme D, Cunha RLOR, Andrade LH (2011) Structure-activity relationships of hypervalent organochalcogenanes as inhibitors of cysteine cathepsins V and S. Bioorg Med Chem 19:2009\u20132014. https:\/\/doi.org\/10.1016\/j.bmc.2011.01.054","journal-title":"Bioorg Med Chem"},{"issue":"3","key":"5814_CR38","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.ecoenv.2010.07.031","volume":"74","author":"S Pinton","year":"2011","unstructured":"Pinton S, Luchese C, Stangherlin EC, Nogueira CW (2011) Acute exposure to diphenyl ditelluride causes oxidative damage in rat lungs. Ecotoxicol Environ Saf 74(3):521\u2013526. https:\/\/doi.org\/10.1016\/j.ecoenv.2010.07.031","journal-title":"Ecotoxicol Environ Saf"},{"key":"5814_CR39","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.phytochem.2007.09.018","volume":"69","author":"T Rezanka","year":"2008","unstructured":"Rezanka T, Sigler K (2008) Biologically active compounds of semi-metals. Phytochemistry 69:585\u2013606. https:\/\/doi.org\/10.1016\/j.phytochem.2007.09.018","journal-title":"Phytochemistry"},{"issue":"3","key":"5814_CR40","doi-asserted-by":"publisher","first-page":"2914","DOI":"10.3390\/ijms24032914","volume":"24","author":"IP S\u00e6b\u00f8","year":"2023","unstructured":"S\u00e6b\u00f8 IP, Bj\u00f8r\u00e5s M, Franzyk H, Helgesen E, Booth JA (2023) Optimization of the hemolysis assay for the assessment of cytotoxicity. Int J Mol Sci 24(3):2914. https:\/\/doi.org\/10.3390\/ijms24032914","journal-title":"Int J Mol Sci"},{"key":"5814_CR41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048780","volume":"7","author":"IAS Pimentel","year":"2012","unstructured":"Pimentel IAS, Paladi CS, Katz S, de Souza J\u00fadice WA, Cunha RLOR, Barbi\u00e9ri CL (2012) In vitro and in vivo activity of an organic tellurium compound on Leishmania (Leishmania) chagasi. PLoS ONE 7:e48780. https:\/\/doi.org\/10.1371\/journal.pone.0048780","journal-title":"PLoS ONE"},{"key":"5814_CR42","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.cbi.2008.10.007","volume":"177","author":"VPP Schiar","year":"2009","unstructured":"Schiar VPP, dos Santos DB, Paix\u00e3o MW, Nogueira CW, Rocha JBT, Zeni G (2009) Human erythrocyte hemolysis induced by selenium and tellurium compounds increased by GSH or glucose: a possible involvement of reactive oxygen species. Chem Biol Interact 177:28\u201333. https:\/\/doi.org\/10.1016\/j.cbi.2008.10.007","journal-title":"Chem Biol Interact"},{"key":"5814_CR43","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1080\/15287394.2020.1780658","volume":"83","author":"JN Silva","year":"2020","unstructured":"Silva JN, Mon\u00e7\u00e3o NBN, Farias RRS, Cito AMGL, Chaves MH, Araujo MRS, Lima DJB, Pessoa C, Lima A, Araujo ECC, Milit\u00e3o GCG, Costa MP, Capasso R, Ferreira PMP (2020) Toxicological, chemopreventive, and cytotoxic potentialities of rare vegetal species and supporting findings for the Brazilian Unified Health System (SUS). J Toxicol Environ Health A 83:525\u2013545. https:\/\/doi.org\/10.1080\/15287394.2020.1780658","journal-title":"J Toxicol Environ Health A"},{"key":"5814_CR44","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1590\/S0100-40422010000700022","volume":"33","author":"REda Silva-L\u00f3pez","year":"2010","unstructured":"Silva-L\u00f3pez REda (2010) Proteases de Leishmania: novos alvos para o desenvolvimento racional de f\u00e1rmacos. Quim Nova 33:1541\u20131548. https:\/\/doi.org\/10.1590\/S0100-40422010000700022","journal-title":"Quim Nova"},{"key":"5814_CR45","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.semcancer.2011.12.003","volume":"22","author":"B Sredni","year":"2012","unstructured":"Sredni B (2012) Immunomodulating tellurium compounds as anti-cancer agents. Semin Cancer Biol 22:60\u201369. https:\/\/doi.org\/10.1016\/j.semcancer.2011.12.003","journal-title":"Semin Cancer Biol"},{"key":"5814_CR46","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.pbb.2008.08.020","volume":"91","author":"EC Stangherlin","year":"2009","unstructured":"Stangherlin EC, Rocha JBT, Nogueira CW (2009) Diphenyl ditelluride impairs short-term memory and alters neurochemical parameters in young rats. Pharmacol Biochem Behav 91:430\u2013435. https:\/\/doi.org\/10.1016\/j.pbb.2008.08.020","journal-title":"Pharmacol Biochem Behav"},{"key":"5814_CR47","doi-asserted-by":"publisher","unstructured":"Tomasetti C, Poling J, Roberts NJ, London Jr NR, Pittman ME, Haffner MC, Vogelstein B (2019) Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence. Proc Nat Acad Sci 116(41): 20482-20488. https:\/\/doi.org\/10.1073\/pnas.1905722116","DOI":"10.1073\/pnas.1905722116"},{"key":"5814_CR48","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.etap.2012.09.009","volume":"34","author":"P Vij","year":"2012","unstructured":"Vij P, Hardej D (2012) Evaluation of tellurium toxicity in transformed and non-transformed human colon cells. Environ Toxicol Pharmacol 34:768\u2013782. https:\/\/doi.org\/10.1016\/j.etap.2012.09.009","journal-title":"Environ Toxicol Pharmacol"},{"key":"5814_CR49","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1021\/om980738d","volume":"18","author":"G Zeni","year":"1999","unstructured":"Zeni G, Chieffi A, Cunha RLOR, Zukerman-Schpector J, Stefani HA, Comasseto JV (1999) Addition reaction of p-methoxyphenyltellurium trichloride to 3-hydroxy alkynes. Organometallics 18:803\u2013806. https:\/\/doi.org\/10.1021\/om980738d","journal-title":"Organometallics"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05814-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05814-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05814-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:35:22Z","timestamp":1787790922000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05814-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":49,"alternative-id":["5814"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05814-8","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]},"assertion":[{"value":"1 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal research was carried out according to the guidelines of the Brazilian College of Animal Experimentation (COBEA) and approved by Animal Ethics Committees at Federal University of Piau\u00ed (CEAU\/UFPI #022\/2015 and #167\/2016)\u00a0and Federal University of S\u00e3o Paulo (CEUA\/UNIFESP #1581\/2009).\u00a0","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}