{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:23:18Z","timestamp":1787664198938,"version":"build-2736575974"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"DOI":"10.1007\/s00210-026-05825-5","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:57:19Z","timestamp":1787619439000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ondansetron versus gabapentin in preventing postoperative nausea and vomiting after laparoscopic sleeve gastrectomy: a randomized study"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5118-9807","authenticated-orcid":false,"given":"Aya Gamal","family":"Moussa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0882-7315","authenticated-orcid":false,"given":"Sahar Mohammed","family":"El-Haggar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1430-2782","authenticated-orcid":false,"given":"Tamer Mosaad","family":"El-Mahdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1071-5416","authenticated-orcid":false,"given":"Tarek Mohamed","family":"Mostafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"5825_CR1","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1093\/bja\/aeu449","volume":"114","author":"S Achuthan","year":"2015","unstructured":"Achuthan S, Singh I, Varthya SB, Srinivasan A, Chakrabarti A, Hota D (2015) Gabapentin prophylaxis for postoperative nausea and vomiting in abdominal surgeries: a quantitative analysis of evidence from randomized controlled clinical trials. Br J Anaesth 114:588\u2013597. https:\/\/doi.org\/10.1093\/bja\/aeu449","journal-title":"Br J Anaesth"},{"key":"5825_CR2","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1080\/11101849.2021.1911112","volume":"37","author":"WS Algharabawy","year":"2021","unstructured":"Algharabawy WS, AbdElrahman TN (2021) Optimal dosing of preoperative gabapentin for prevention of postoperative nausea and vomiting after abdominal laparoscopic surgery: a randomized prospective comparative study. Egypt J Anaesth 37:174\u2013181. https:\/\/doi.org\/10.1080\/11101849.2021.1911112","journal-title":"Egypt J Anaesth"},{"key":"5825_CR3","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1097\/00000542-199909000-00022","volume":"91","author":"CC Apfel","year":"1999","unstructured":"Apfel CC, Laara E, Koivuranta M, Greim CA, Roewer N (1999) A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers. Anesthesiology 91:693\u2013700. https:\/\/doi.org\/10.1097\/00000542-199909000-00022","journal-title":"Anesthesiology"},{"key":"5825_CR4","doi-asserted-by":"publisher","first-page":"631","DOI":"10.2147\/JPR.S112626","volume":"9","author":"S Arumugam","year":"2016","unstructured":"Arumugam S, Lau CS, Chamberlain RS (2016) Use of preoperative gabapentin significantly reduces postoperative opioid consumption: a meta-analysis. J Pain Res 9:631\u2013640. https:\/\/doi.org\/10.2147\/JPR.S112626","journal-title":"J Pain Res"},{"key":"5825_CR5","doi-asserted-by":"publisher","unstructured":"Avci G, Kansu AN (2024) The effects and comparative efficacy of dexamethasone and gabapentin on nausea and vomiting after laparoscopic cholecystectomy. JARSS 32:96\u2013102. https:\/\/doi.org\/10.54875\/jarss.2024.50251.","DOI":"10.54875\/jarss.2024.50251"},{"key":"5825_CR6","first-page":"33","volume":"43","author":"A Balasubramanian","year":"2007","unstructured":"Balasubramanian A, Flareau B, Sourbeer J (2007) Syndrome of inappropriate antidiuretic hormone secretion. Hosp Physician 43:33\u201339","journal-title":"Hosp Physician"},{"key":"5825_CR7","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1381\/0960892055002248","volume":"15","author":"A Baltasar","year":"2005","unstructured":"Baltasar A, Serra C, Perez N, Bou R, Bengochea M, Ferri L (2005) Laparoscopic sleeve gastrectomy: a multi-purpose bariatric operation. Obes Surg 15:1124\u20131128. https:\/\/doi.org\/10.1381\/0960892055002248","journal-title":"Obes Surg"},{"key":"5825_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/bmjopen-2020-041176","volume":"10","author":"S Baos","year":"2020","unstructured":"Baos S, Rogers CA, Abbadi R, Alzetani A, Casali G, Chauhan N et al (2020) Effectiveness, cost-effectiveness and safety of gabapentin versus placebo as an adjunct to multimodal pain regimens in surgical patients: protocol of a placebo controlled randomised controlled trial with blinding (GAP study). BMJ Open 10:1\u20138. https:\/\/doi.org\/10.1136\/bmjopen-2020-041176","journal-title":"BMJ Open"},{"key":"5825_CR9","first-page":"26","volume":"19","author":"JC Bryson","year":"1992","unstructured":"Bryson JC (1992) Clinical safety of ondansetron. Semin Oncol 19:26\u201332","journal-title":"Semin Oncol"},{"key":"5825_CR10","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/32897","volume":"392","author":"YQ Cao","year":"1998","unstructured":"Cao YQ, Mantyh PW, Carlson EJ, Gillespie AM, Epstein CJ, Basbaum AI (1998) Primary afferent tachykinins are required to experience moderate to intense pain. Nature 392:390\u2013394. https:\/\/doi.org\/10.1038\/32897","journal-title":"Nature"},{"key":"5825_CR11","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/631756","volume":"2014","author":"CY Chang","year":"2014","unstructured":"Chang CY, Challa CK, Shah J, Eloy JD (2014) Gabapentin in acute postoperative pain management. Biomed Res Int 2014:631756. https:\/\/doi.org\/10.1155\/2014\/631756","journal-title":"Biomed Res Int"},{"key":"5825_CR12","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1007\/s12630-013-9890-1","volume":"60","author":"H Clarke","year":"2013","unstructured":"Clarke H, Kirkham KR, Orser BA, Katznelson R, Mitsakakis N, Ko R, Snyman A, Ma M, Katz J (2013) Gabapentin reduces preoperative anxiety and pain catastrophizing in highly anxious patients prior to major surgery: a blinded randomized placebo-controlled trial. Can J Anaesth 60:432\u2013443. https:\/\/doi.org\/10.1007\/s12630-013-9890-1","journal-title":"Can J Anaesth"},{"key":"5825_CR13","doi-asserted-by":"publisher","first-page":"716","DOI":"10.2174\/138945009788982513","volume":"10","author":"M Dauri","year":"2009","unstructured":"Dauri M, Faria S, Gatti A, Celidonio L, Carpenedo R, Sabato AF (2009) Gabapentin and pregabalin for the acute post-operative pain management. A systematic-narrative review of the recent clinical evidences. Curr Drug Targets 10:716\u2013733. https:\/\/doi.org\/10.2174\/138945009788982513","journal-title":"Curr Drug Targets"},{"key":"5825_CR14","doi-asserted-by":"publisher","first-page":"19","DOI":"10.2478\/rjaic-2021-0003","volume":"28","author":"S Dey","year":"2022","unstructured":"Dey S, Chanu SM, Dev P, Borthakur M, Karim HMR, Yunus M (2022) Antiemetic efficacy of palonosetron compared with the combination of ondansetron and dexamethasone for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic gynaecological surgery. Rom J Anaesth Intensive Care 28:19\u201324. https:\/\/doi.org\/10.2478\/rjaic-2021-0003","journal-title":"Rom J Anaesth Intensive Care"},{"key":"5825_CR15","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1007\/s12663-020-01366-3","volume":"19","author":"P Dubey","year":"2020","unstructured":"Dubey P, Thapliyal GK, Ranjan A (2020) A comparative study between ondansetron and gabapentin for prevention of postoperative nausea and vomiting following maxillofacial surgery. J Maxillofac Oral Surg 19:616\u2013623. https:\/\/doi.org\/10.1007\/s12663-020-01366-3","journal-title":"J Maxillofac Oral Surg"},{"key":"5825_CR16","doi-asserted-by":"publisher","first-page":"349","DOI":"10.4236\/ojanes.2020.1010031","volume":"10","author":"AA Elrashidy","year":"2020","unstructured":"Elrashidy AA, Elsherif M, Elhag W, Abdelaziem O, Abdelaziem S, Abdel-Rahman RS (2020) Palonosetron versus ondansetron as prophylaxis against postoperative nausea and vomiting (PONV) after laparoscopic sleeve gastrectomy: a randomized controlled trial. Open J Anesthesiol 10:349\u2013360. https:\/\/doi.org\/10.4236\/ojanes.2020.1010031","journal-title":"Open J Anesthesiol"},{"key":"5825_CR17","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1007\/s40122-021-00330-4","volume":"10","author":"XM Fan","year":"2021","unstructured":"Fan XM, Ren YF, Fu X, Wu H, Ye X, Jiang YF, You FM (2021) Gabapentin has longer-term efficacy for the treatment of chronic pelvic pain in women: a systematic review and pilot meta-analysis. Pain Ther 10:1673\u20131689. https:\/\/doi.org\/10.1007\/s40122-021-00330-4","journal-title":"Pain Ther"},{"key":"5825_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11164695","volume":"11","author":"D Fenikowski","year":"2022","unstructured":"Fenikowski D, Tomaszek L, Mazurek H, Gawron D, Maciejewski P (2022) The effects of gabapentin on post-operative pain and anxiety, morphine consumption and patient satisfaction in paediatric patients following the ravitch procedure-a randomised, double-blind, placebo-controlled, phase 4 trial. J Clin Med 11:4695. https:\/\/doi.org\/10.3390\/jcm11164695","journal-title":"J Clin Med"},{"key":"5825_CR19","doi-asserted-by":"publisher","first-page":"21S","DOI":"10.1177\/0148607113496117","volume":"37","author":"CC Finnerty","year":"2013","unstructured":"Finnerty CC, Mabvuure NT, Ali A, Kozar RA, Herndon DN (2013) The surgically induced stress response. JPEN J Parenter Enteral Nutr 37:21S-S29. https:\/\/doi.org\/10.1177\/0148607113496117","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"5825_CR20","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.jopan.2023.06.005","volume":"39","author":"KA Froehlich","year":"2024","unstructured":"Froehlich KA, Deleon ZG, Tubog TD (2024) Effects of gabapentin on postoperative pain and opioid consumption following laparoscopic cholecystectomy: a systematic review andmeta-analysis. J Perianesth Nurs 39:132\u2013141. https:\/\/doi.org\/10.1016\/j.jopan.2023.06.005","journal-title":"J Perianesth Nurs"},{"key":"5825_CR21","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1213\/ane.0000000000004833","volume":"131","author":"TJ Gan","year":"2020","unstructured":"Gan TJ, Belani KG, Bergese S, Chung F, Diemunsch P, Habib AS, Jin Z, Kovac AL et al (2020) Fourth consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg 131:411\u2013448. https:\/\/doi.org\/10.1213\/ane.0000000000004833","journal-title":"Anesth Analg"},{"key":"5825_CR22","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1136\/emj.20.4.306","volume":"20","author":"P Gosling","year":"2003","unstructured":"Gosling P (2003) Salt of the earth or a drop in the ocean? A pathophysiological approach to fluid resuscitation. Emerg Med J 20:306\u2013315. https:\/\/doi.org\/10.1136\/emj.20.4.306","journal-title":"Emerg Med J"},{"key":"5825_CR23","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1213\/ANE.0000000000001120","volume":"122","author":"MC Grant","year":"2016","unstructured":"Grant MC, Lee H, Page AJ, Hobson D, Wick E, Wu CL (2016) The effect of preoperative gabapentin on postoperative nausea and vomiting: a meta-analysis. Anesth Analg 122:976\u2013985. https:\/\/doi.org\/10.1213\/ANE.0000000000001120","journal-title":"Anesth Analg"},{"key":"5825_CR24","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.bpa.2020.07.003","volume":"34","author":"K Gress","year":"2020","unstructured":"Gress K, Urits I, Viswanath O, Urman RD (2020) Clinical and economic burden of postoperative nausea and vomiting: analysis of existing cost data. Best Pract Res Clin Anaesthesiol 34:681\u2013686. https:\/\/doi.org\/10.1016\/j.bpa.2020.07.003","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"5825_CR25","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1007\/s00221-014-3905-1","volume":"232","author":"TJR Guttuso","year":"2014","unstructured":"Guttuso TJR (2014) Gabapentin\u2019s anti-nausea and anti-emetic effects: a review. Exp Brain Res 232:2535\u20132539. https:\/\/doi.org\/10.1007\/s00221-014-3905-1","journal-title":"Exp Brain Res"},{"key":"5825_CR26","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1001\/archsurg.1978.01370170059011","volume":"113","author":"M Haas","year":"1978","unstructured":"Haas M, Glick SM (1978) Radioimmunoassayable plasma vasopressin associated with surgery. Arch Surg 113:597\u2013600. https:\/\/doi.org\/10.1001\/archsurg.1978.01370170059011","journal-title":"Arch Surg"},{"key":"5825_CR27","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1111\/aas.12884","volume":"61","author":"TA Halliday","year":"2017","unstructured":"Halliday TA, Sundqvist J, Hultin M, Walld\u00e9n J (2017) Post-operative nausea and vomiting in bariatric surgery patients: an observational study. Acta Anaesthesiol Scand 61:471\u2013479. https:\/\/doi.org\/10.1111\/aas.12884","journal-title":"Acta Anaesthesiol Scand"},{"key":"5825_CR28","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s00423-025-03607-w","volume":"410","author":"AT Hamantepe","year":"2025","unstructured":"Hamantepe AT, G\u00f6n\u00fcll\u00fc E, F\u0131rt\u0131na G, \u0130lhan O, Y\u00fcksel A, Karaman K (2025) Sleeve gastrectomy with antral resection provides more effective weight loss in patients with super obesity. Langenbecks Arch Surg 410:35\u201342. https:\/\/doi.org\/10.1007\/s00423-025-03607-w","journal-title":"Langenbecks Arch Surg"},{"key":"5825_CR29","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.2460\/ajvr.2000.61.1273","volume":"61","author":"JG Hauptman","year":"2000","unstructured":"Hauptman JG, Richter MA, Wood SL, Nachreiner RF (2000) Effects of anesthesia, surgery, and intravenous administration of fluids on plasma antidiuretic hormone concentrations in healthy dogs. Am J Vet Res 61:1273\u20131276. https:\/\/doi.org\/10.2460\/ajvr.2000.61.1273","journal-title":"Am J Vet Res"},{"key":"5825_CR30","doi-asserted-by":"publisher","first-page":"22","DOI":"10.4103\/2277-9175.150388","volume":"4","author":"M Heidari","year":"2015","unstructured":"Heidari M, Honarmand A, Safavi M, Chitsazi M, Khalighinejad F (2015) Gabapentin in preventing postoperative nausea and vomiting after middle ear surgery in adults: a double-blinded randomized clinical trial study. Adv Biomed Res 4:22\u201326. https:\/\/doi.org\/10.4103\/2277-9175.150388","journal-title":"Adv Biomed Res"},{"key":"5825_CR31","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ejphar.2013.10.037","volume":"722","author":"CC Horn","year":"2014","unstructured":"Horn CC, Wallisch WJ, Homanics GE, Williams JP (2014) Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting. Eur J Pharmacol 722:55\u201366. https:\/\/doi.org\/10.1016\/j.ejphar.2013.10.037","journal-title":"Eur J Pharmacol"},{"key":"5825_CR32","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jocn.2023.08.010","volume":"116","author":"Y Hou","year":"2023","unstructured":"Hou Y, Liang H, Fan C, Feng Y (2023) 5-Hydroxytryptamine and postoperative nausea and vomiting after microvascular decompression surgery. J Clin Neurosci 116:27\u201331. https:\/\/doi.org\/10.1016\/j.jocn.2023.08.010","journal-title":"J Clin Neurosci"},{"key":"5825_CR33","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.12669\/pjms.38.6.5518","volume":"38","author":"K Ilyas","year":"2022","unstructured":"Ilyas K, Latif R, Hafeez Z (2022) Effect of pre-operative administration of single-dose of gabapentin on postop surgical pain in patients undergoing sternotomy for CABG. Pak J Med Sci 38:1466\u20131470. https:\/\/doi.org\/10.12669\/pjms.38.6.5518","journal-title":"Pak J Med Sci"},{"key":"5825_CR34","doi-asserted-by":"publisher","first-page":"67","DOI":"10.4103\/joacp.JOACP_439_19","volume":"37","author":"R Jain","year":"2021","unstructured":"Jain R, Kumar M, Singh T, Rautela RS, Kumar S (2021) Effect of oral gabapentin premedication on hemodynamic parameters and postoperative pain in patients of laparoscopic cholecystectomy: a randomized double-blind controlled study. J Anaesthesiol Clin Pharmacol 37:67\u201372. https:\/\/doi.org\/10.4103\/joacp.JOACP_439_19","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"5825_CR35","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s40981-016-0034-9","volume":"2","author":"T Kadota","year":"2016","unstructured":"Kadota T, Kakuta N, Horikawa YT, Tsutsumi R, Oyama T, Tanaka K, Tsutsumi YM (2016) Plasma substance P concentrations in patients undergoing general anesthesia: an objective marker associated with postoperative nausea and vomiting. JA Clin Rep 2:4\u20139. https:\/\/doi.org\/10.1186\/s40981-016-0034-9","journal-title":"JA Clin Rep"},{"key":"5825_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7759\/cureus.55062","volume":"16","author":"FA Kamal","year":"2024","unstructured":"Kamal FA, Fernet L, Rodriguez M (2024) Nutritional deficiencies before and after bariatric surgery in low-and high-income countries: prevention and treatment. Cureus 16:1\u201313. https:\/\/doi.org\/10.7759\/cureus.55062","journal-title":"Cureus"},{"key":"5825_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7759\/cureus.46719","volume":"15","author":"S Kaur","year":"2023","unstructured":"Kaur S, Turka S, Kaur BT, Tuteja RD, Kumar M, Jit Singh Bajwa S, Kurdi MS, Sutagatti AJ (2023) Comparison of the efficacy of pregabalin and gabapentin for preemptive analgesia in laparoscopic cholecystectomy patients: a randomised double-blind study. Cureus 15:1\u20139. https:\/\/doi.org\/10.7759\/cureus.46719","journal-title":"Cureus"},{"key":"5825_CR38","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1159\/000252836","volume":"19","author":"S Khademi","year":"2010","unstructured":"Khademi S, Ghaffarpasand F, Heiran HR, Asefi A (2010) Effects of preoperative gabapentin on postoperative nausea and vomiting after open cholecystectomy: a prospective randomized double-blind placebo-controlled study. Med Princ Pract 19:57\u201360. https:\/\/doi.org\/10.1159\/000252836","journal-title":"Med Princ Pract"},{"key":"5825_CR39","first-page":"19","volume":"21","author":"MA Khan","year":"2017","unstructured":"Khan MA, Siddiqi KJ, Khan MS (2017) Prophylactic use of gabapentin to reduce postoperative nausea and vomiting in patients undergoing diagnostic gynecological laparoscopy. Anaesth Pain Intensive Care 21:19\u201324","journal-title":"Anaesth Pain Intensive Care"},{"key":"5825_CR40","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12871-017-0357-8","volume":"17","author":"KM Kim","year":"2017","unstructured":"Kim KM, Huh J, Lee SK, Park EY, Lee JM, Kim HJ (2017) Combination of gabapentin and ramosetron for the prevention of postoperative nausea and vomiting after gynecologic laparoscopic surgery: a prospective randomized comparative study. BMC Anesthesiol 17:65\u201374. https:\/\/doi.org\/10.1186\/s12871-017-0357-8","journal-title":"BMC Anesthesiol"},{"key":"5825_CR41","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1093\/bja\/aem316","volume":"99","author":"V Kong","year":"2007","unstructured":"Kong V, Irwin M (2007) Gabapentin: a multimodal perioperative drug? Br J Anaesth 99:775\u2013786","journal-title":"Br J Anaesth"},{"key":"5825_CR42","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1007\/s40265-016-0663-3","volume":"76","author":"AL Kovac","year":"2016","unstructured":"Kovac AL (2016) Comparative pharmacology and guide to the use of the serotonin 5-HT3 receptor antagonists for postoperative nausea and vomiting. Drugs 76:1719\u20131735. https:\/\/doi.org\/10.1007\/s40265-016-0663-3","journal-title":"Drugs"},{"key":"5825_CR43","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1097\/EJA.0000000000000080","volume":"31","author":"P Kranke","year":"2014","unstructured":"Kranke P, Diemunsch P (2014) The 2014 consensus guidelines for the management of postoperative nausea and vomiting: a leapfrog towards a postoperative nausea and vomiting-free hospital. Eur J Anaesthesiol 31:651\u2013653. https:\/\/doi.org\/10.1097\/EJA.0000000000000080","journal-title":"Eur J Anaesthesiol"},{"key":"5825_CR44","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1016\/j.soard.2020.05.017","volume":"16","author":"BS Kushner","year":"2020","unstructured":"Kushner BS, Freeman D, Sparkman J, Salles A, Eagon JC, Eckhouse SR (2020) Assessment of postoperative nausea and vomiting after bariatric surgery using a validated questionnaire. Surg Obes Relat Dis 16:1505\u20131513. https:\/\/doi.org\/10.1016\/j.soard.2020.05.017","journal-title":"Surg Obes Relat Dis"},{"key":"5825_CR45","doi-asserted-by":"publisher","first-page":"384","DOI":"10.4097\/kjae.2014.67.6.384","volume":"67","author":"BG Lim","year":"2014","unstructured":"Lim BG, Choi SS, Jeong YJ, Lim YJ, Kim YC, Park KU, Lee DK, Lee MK (2014) The relationship between perioperative nausea and vomiting and serum serotonin concentrations in patients undergoing cesarean section under epidural anesthesia. Korean J Anesthesiol 67:384\u2013390. https:\/\/doi.org\/10.4097\/kjae.2014.67.6.384","journal-title":"Korean J Anesthesiol"},{"key":"5825_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0146400","volume":"11","author":"B Lisowska","year":"2016","unstructured":"Lisowska B, Siewruk K, Lisowski A (2016) Substance P and acute pain in patients undergoing orthopedic surgery. PLoS One 11:1\u201311. https:\/\/doi.org\/10.1371\/journal.pone.0146400","journal-title":"PLoS One"},{"key":"5825_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0285943","volume":"18","author":"L Lu","year":"2023","unstructured":"Lu L, Xie C, Li X, Zhou Y, Yin Z, Wei P et al (2023) Efficacy and safety of electrical acupoint stimulation for postoperative nausea and vomiting: a systematic review and meta-analysis. PLoS ONE 18:1\u201321. https:\/\/doi.org\/10.1371\/journal.pone.0285943","journal-title":"PLoS ONE"},{"key":"5825_CR48","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1053\/j.jvca.2009.10.023","volume":"24","author":"F Menda","year":"2010","unstructured":"Menda F, K\u00f6ner O, Say\u0131n M, Ergeno\u011flu M, K\u00fc\u00e7\u00fckaksu S, Ayka\u00e7 B (2010) Effects of single-dose gabapentin on postoperative pain and morphine consumption after cardiac surgery. J Cardiothorac Vasc Anesth 24:808\u2013813. https:\/\/doi.org\/10.1053\/j.jvca.2009.10.023","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"5825_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/2314808x.2023.2184306","volume":"10","author":"SB Mohamed","year":"2023","unstructured":"Mohamed SB, Elkenawy MF, Elsaid TO, Mashaly GES (2023) Serum substance P level as a marker for subclinical rheumatoid arthritis activity. Egypt J Basic Appl Sci 10:1\u201310. https:\/\/doi.org\/10.1080\/2314808x.2023.2184306","journal-title":"Egypt J Basic Appl Sci"},{"key":"5825_CR50","doi-asserted-by":"publisher","first-page":"153","DOI":"10.3923\/ijp.2008.153.156","volume":"4","author":"SS Mohammadi","year":"2008","unstructured":"Mohammadi SS, Seyedi M (2008) Comparing oral gabapentin versus clonidine as premedication on early postoperative pain, nausea and vomiting after general anesthesia. Int J Pharmacol 4:153\u2013156. https:\/\/doi.org\/10.3923\/ijp.2008.153.156","journal-title":"Int J Pharmacol"},{"key":"5825_CR51","doi-asserted-by":"publisher","unstructured":"Mousa SO, Abd Elwahab AT, Abdelrazik AN (2023) A single preoperative dose of Gabapentin decreases postoperative pain in ambulatory anal surgeries. Minia J Med Res 34:97\u2013101. https:\/\/doi.org\/10.21608\/mjmr.2023.174463.1219","DOI":"10.21608\/mjmr.2023.174463.1219"},{"key":"5825_CR52","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1097\/01.sla.0000151791.93571.70","volume":"241","author":"NT Nguyen","year":"2005","unstructured":"Nguyen NT, Wolfe BM (2005) The physiologic effects of pneumoperitoneum in the morbidly obese. Ann Surg 241:219\u2013226. https:\/\/doi.org\/10.1097\/01.sla.0000151791.93571.70","journal-title":"Ann Surg"},{"key":"5825_CR53","doi-asserted-by":"publisher","first-page":"90","DOI":"10.15406\/aowmc.2020.10.00312","volume":"10","author":"T Omer","year":"2020","unstructured":"Omer T (2020) The causes of obesity: an in-depth review. Adv Obes Weight Manag Control 10:90\u201394. https:\/\/doi.org\/10.15406\/aowmc.2020.10.00312","journal-title":"Adv Obes Weight Manag Control"},{"key":"5825_CR54","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1007\/s11695-024-07129-0","volume":"34","author":"E Ortiz","year":"2024","unstructured":"Ortiz E, Gonz\u00e1lez AI, Jaime V, Ortiz E, Gonz\u00e1lez AI, Jaime V, Guzm\u00e1n JA, Esparza I, Orozco JO, Guerrero MA, Ramos A, Zerrweck C (2024) The impact of aprepitant on nausea and vomiting following laparoscopic sleeve gastrectomy: a blinded randomized controlled trial. Obes Surg 34:1316\u20131323. https:\/\/doi.org\/10.1007\/s11695-024-07129-0","journal-title":"Obes Surg"},{"key":"5825_CR55","first-page":"97","volume":"52","author":"CK Pandey","year":"2006","unstructured":"Pandey CK, Priye S, Ambesh SP, Singh S, Singh U, Singh PK (2006) Prophylactic gabapentin for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled study. J Postgrad Med 52:97\u2013100","journal-title":"J Postgrad Med"},{"key":"5825_CR56","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1001\/jamainternmed.2022.3680","volume":"182","author":"CM Park","year":"2022","unstructured":"Park CM, Inouye SK, Marcantonio ER, Metzger E, Bateman BT, Lie JJ, Lee SB, Levin R, Kim DH (2022) Perioperative gabapentin use and in-hospital adverse clinical events among older adults after major surgery. JAMA Intern Med 182:1117\u20131127. https:\/\/doi.org\/10.1001\/jamainternmed.2022.3680","journal-title":"JAMA Intern Med"},{"key":"5825_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e12430","volume":"8","author":"Y Qian","year":"2022","unstructured":"Qian Y, Zhu JK, Hou BL, Sun YE, Gu XP, Ma ZL (2022) Risk factors of postoperative nausea and vomiting following ambulatory surgery: a retrospective case-control study. Heliyon 8:e12430. https:\/\/doi.org\/10.1016\/j.heliyon.2022.e12430","journal-title":"Heliyon"},{"key":"5825_CR58","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ijsu.2018.09.010","volume":"59","author":"J Ruiz-Tovar","year":"2018","unstructured":"Ruiz-Tovar J, Zubiaga L, Mu\u00f1oz JL, Llavero C (2018) Incidence of postoperative nausea and vomiting after laparoscopic sleeve gastrectomy with staple line reinforcement with oversewing and staple line inversion vs buttressing material: a randomized clinical trial. Int J Surg 59:75\u201379. https:\/\/doi.org\/10.1016\/j.ijsu.2018.09.010","journal-title":"Int J Surg"},{"key":"5825_CR59","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1254\/jphs.91.87","volume":"9","author":"R Saito","year":"2003","unstructured":"Saito R, Takano Y, Kamiya HO (2003) Roles of substance P and NK(1) receptor in the brainstem in the development of emesis. J Pharmacol Sci 9:87\u201394. https:\/\/doi.org\/10.1254\/jphs.91.87","journal-title":"J Pharmacol Sci"},{"key":"5825_CR60","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1097\/ALN.0b013e3182a9a896","volume":"119","author":"PC Schmidt","year":"2013","unstructured":"Schmidt PC, Ruchelli G, Mackey SC, Carroll IR (2013) Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain. Anesthesiology 119:1215\u20131221. https:\/\/doi.org\/10.1097\/ALN.0b013e3182a9a896","journal-title":"Anesthesiology"},{"key":"5825_CR61","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1016\/j.soard.2021.08.005","volume":"17","author":"R Schumann","year":"2021","unstructured":"Schumann R, Ziemann-Gimmel P, Sultana A, Eldawlatly AA, Kothari SN, Shah S, Wadhwa A (2021) Postoperative nausea and vomiting in bariatric surgery: a position statement endorsed by the ASMBS and the ISPCOP. Surg Obes Relat Dis 17:1829\u20131833. https:\/\/doi.org\/10.1016\/j.soard.2021.08.005","journal-title":"Surg Obes Relat Dis"},{"key":"5825_CR62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmed.2025.1481720","volume":"12","author":"X Shan","year":"2025","unstructured":"Shan X, Yang Y, Xiao X, Zhang M, Chen R, Huang Q, Gao Y, Sun X (2025) Enhanced efficacy of aprepitant-based triple prophylaxis in preventing postoperative nausea and vomiting following metabolic bariatric surgery: a single-center, retrospective cohort study. Front Med (Lausanne) 12:1\u201310. https:\/\/doi.org\/10.3389\/fmed.2025.1481720","journal-title":"Front Med (Lausanne)"},{"key":"5825_CR63","first-page":"47","volume":"25","author":"RN Smith","year":"1989","unstructured":"Smith RN (1989) Safety of ondansetron. Eur J Cancer Clin Oncol 25:47\u201354","journal-title":"Eur J Cancer Clin Oncol"},{"key":"5825_CR64","doi-asserted-by":"publisher","first-page":"3085","DOI":"10.1007\/s00464-019-07058-5","volume":"34","author":"S Suh","year":"2020","unstructured":"Suh S, Helm M, Kindel TL, Goldblatt MI, Gould JC, Higgins RM (2020) The impact of nausea on post-operative outcomes in bariatric surgery patients. Surg Endosc 34:3085\u20133091. https:\/\/doi.org\/10.1007\/s00464-019-07058-5","journal-title":"Surg Endosc"},{"key":"5825_CR65","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.ijso.2020.10.002","volume":"27","author":"D Teshome","year":"2020","unstructured":"Teshome D, Fenta E, Hailu S (2020) Preoperative prevention and postoperative management of nausea and vomiting in resource limited setting: a systematic review and guideline. Int J Surg Open 27:10\u201317. https:\/\/doi.org\/10.1016\/j.ijso.2020.10.002","journal-title":"Int J Surg Open"},{"key":"5825_CR66","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1046\/j.1365-2044.1999.00704.x","volume":"54","author":"MR Tram\u00e8r","year":"1999","unstructured":"Tram\u00e8r MR, Phillips C, Reynolds DJM, McQuay HJ, Moore RA (1999) Cost-effectiveness of ondansetron for postoperative nausea and vomiting. Anaesthesia 54:226\u2013234. https:\/\/doi.org\/10.1046\/j.1365-2044.1999.00704.x","journal-title":"Anaesthesia"},{"key":"5825_CR67","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3390\/jpm14020151","volume":"14","author":"AM Velardi","year":"2024","unstructured":"Velardi AM, Anoldo P, Nigro S, Navarra G (2024) Advancements in bariatric surgery: a comparative review of laparoscopic and robotic techniques. J Pers Med 14:151\u2013158. https:\/\/doi.org\/10.3390\/jpm14020151","journal-title":"J Pers Med"},{"key":"5825_CR68","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.bpa.2008.03.004","volume":"22","author":"JL Vincent","year":"2008","unstructured":"Vincent JL, Su F (2008) Physiology and pathophysiology of the vasopressinergic system. Best Pract Res Clin Anaesthesiol 22:243\u2013252. https:\/\/doi.org\/10.1016\/j.bpa.2008.03.004","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"5825_CR69","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1007\/s13410-024-01414-545(4):996-1009","volume":"45","author":"B Wu","year":"2025","unstructured":"Wu B, Wang J, Chen Q, Yang W, Qu H, Wang Y, Sun G, Niu B (2025) The alteration of lipid metabolism and its correlation with glycometabolism following laparoscopic sleeve gastrectomy: a meta-analysis. Int J Diabetes Dev Ctries 45:996\u20131009. https:\/\/doi.org\/10.1007\/s13410-024-01414-545(4):996-1009","journal-title":"Int J Diabetes Dev Ctries"},{"key":"5825_CR70","doi-asserted-by":"publisher","first-page":"6609","DOI":"10.21037\/jtd-20-2323","volume":"12","author":"K Yamashita","year":"2020","unstructured":"Yamashita K, Abe T, Hayata Y, Hirose T, Hiraga S, Fukuba R, Takemura J, Tonomura R, Yamamoto K, Yokoyama S, Taniguchi S (2020) Copeptin concentration following cardiac surgery as a prognostic marker of postoperative acute kidney injury: a prospective cohort study. J Thorac Dis 12:6609\u20136617. https:\/\/doi.org\/10.21037\/jtd-20-2323","journal-title":"J Thorac Dis"},{"key":"5825_CR71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms22115797","volume":"22","author":"W Zhong","year":"2021","unstructured":"Zhong W, Shahbaz O, Teskey G, Beever A, Kachour N, Venketaraman V, Darmani NA (2021) Mechanisms of nausea and vomiting: current knowledge and recent advances in intracellular emetic signaling systems. Int J Mol Sci 22:1\u201333. https:\/\/doi.org\/10.3390\/ijms22115797","journal-title":"Int J Mol Sci"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05825-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05825-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05825-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:02:42Z","timestamp":1787662962000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05825-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":71,"alternative-id":["5825"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05825-5","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,25]]},"assertion":[{"value":"1 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was conducted in accordance with the ethical standards declaration of Helsinki in 1964 and its later amendments. The Research Ethics Committee of Tanta University approved the study (Approval Code: 35647\/8\/22). The study was registered as a clinical trial on ClinicalTrials.gov with an ID (NCT05620641).","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}