{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T01:24:12Z","timestamp":1787361852212,"version":"build-2736575974"},"reference-count":100,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005279","name":"Universidade Federal Do Piau\u00ed","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005279","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"DOI":"10.1007\/s00210-026-05829-1","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T01:00:25Z","timestamp":1787360425000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["VLA-4 integrin modulates cellular responses to sorafenib in metastasis-related processes of B16F10 melanoma cells"],"prefix":"10.1007","author":[{"given":"Mickael Laudrup","family":"de Sousa Cavalcante","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio","family":"da Silva Paix\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaio Filipe Nunes","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semiramis Jamil Hadad","family":"do Monte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester Miranda","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Pires Goulart","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Marcelo","family":"de Castro e Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Michel Pinheiro","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4370-0803","authenticated-orcid":false,"given":"Dalton","family":"Dittz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"key":"5829_CR1","doi-asserted-by":"publisher","first-page":"15442","DOI":"10.1074\/jbc.272.24.15442","volume":"272","author":"H Abedi","year":"1997","unstructured":"Abedi H, Zachary I (1997) Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells. J Biol Chem 272:15442\u201315451. https:\/\/doi.org\/10.1074\/jbc.272.24.15442","journal-title":"J Biol Chem"},{"key":"5829_CR2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.annonc.2024.11.006","volume":"36","author":"T Amaral","year":"2025","unstructured":"Amaral T, Ottaviano M, Arance A et al (2025) Cutaneous melanoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol 36:10\u201330. https:\/\/doi.org\/10.1016\/j.annonc.2024.11.006","journal-title":"Ann Oncol"},{"key":"5829_CR3","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1016\/j.cell.2019.01.021","volume":"176","author":"RS Apte","year":"2019","unstructured":"Apte RS, Chen DS, Ferrara N (2019) VEGF in signaling and disease: beyond discovery and development. Cell 176:1248\u20131264. https:\/\/doi.org\/10.1016\/j.cell.2019.01.021","journal-title":"Cell"},{"key":"5829_CR4","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/jcmm.14755","volume":"24","author":"MG Atzori","year":"2020","unstructured":"Atzori MG, Ceci C, Ruffini F et al (2020) Role of VEGFR-1 in melanoma acquired resistance to the BRAF inhibitor vemurafenib. J Cell Mol Med 24:465\u2013475. https:\/\/doi.org\/10.1111\/jcmm.14755","journal-title":"J Cell Mol Med"},{"key":"5829_CR5","doi-asserted-by":"publisher","DOI":"10.4155\/FDD-2022-0010","author":"PI Back","year":"2023","unstructured":"Back PI, Rascon K, Islam MR et al (2023) Targeting immune checkpoint pathways in melanoma: triumphs and challenges. Future Drug Discov. https:\/\/doi.org\/10.4155\/FDD-2022-0010","journal-title":"Future Drug Discov"},{"key":"5829_CR6","doi-asserted-by":"publisher","first-page":"6684","DOI":"10.1038\/sj.onc.1205911","volume":"21","author":"A Baldi","year":"2002","unstructured":"Baldi A, De Luca A, Morini M et al (2002) The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells. Oncogene 21:6684\u20136688. https:\/\/doi.org\/10.1038\/sj.onc.1205911","journal-title":"Oncogene"},{"key":"5829_CR7","doi-asserted-by":"publisher","unstructured":"Bile F, Sparaco M, Ruocco E et al (2024) Dermatological neoplastic diseases complicating treatment with monoclonal antibodies for multiple sclerosis. J Clin Med 13. https:\/\/doi.org\/10.3390\/jcm13175133","DOI":"10.3390\/jcm13175133"},{"key":"5829_CR8","doi-asserted-by":"publisher","unstructured":"Bobadilla AVP, Ar\u00e9valo J, Sarr\u00f3 E et al (2019) In vitro cell migration quantification method for scratch assays. J R Soc Interface 16. https:\/\/doi.org\/10.1098\/rsif.2018.0709","DOI":"10.1098\/rsif.2018.0709"},{"key":"5829_CR9","doi-asserted-by":"publisher","unstructured":"Boz Er AB, Sheldrake HM, Sutherland M (2024) Overcoming vemurafenib resistance in metastatic melanoma: targeting integrins to improve treatment efficacy. Int J Mol Scil 25. https:\/\/doi.org\/10.3390\/ijms25147946","DOI":"10.3390\/ijms25147946"},{"key":"5829_CR10","doi-asserted-by":"publisher","unstructured":"Brooks DLP, Schwab LP, Krutilina R et al (2016) ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer models. Mol Cancer 15:26. https:\/\/doi.org\/10.1186\/s12943-016-0510-x","DOI":"10.1186\/s12943-016-0510-x"},{"key":"5829_CR11","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1023\/A:1013368509855","volume":"228","author":"R Buchli","year":"2001","unstructured":"Buchli R, Ndoye A, Arredondo J et al (2001) Identification and characterization of muscarinic acetylcholine receptor subtypes expressed in human skin melanocytes. Mol Cell Biochem 228:57\u201372. https:\/\/doi.org\/10.1023\/A:1013368509855","journal-title":"Mol Cell Biochem"},{"key":"5829_CR12","doi-asserted-by":"publisher","unstructured":"Byron A, Askari JA, Humphries JD et al (2015) A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting. Nat Commun 6:6135. https:\/\/doi.org\/10.1038\/ncomms7135","DOI":"10.1038\/ncomms7135"},{"key":"5829_CR13","doi-asserted-by":"publisher","first-page":"3145","DOI":"10.1158\/0008-5472.CAN-13-0011","volume":"73","author":"WS Carbonell","year":"2013","unstructured":"Carbonell WS, Delay M, Jahangiri A et al (2013) \u03b21 integrin targeting potentiates antiangiogenic therapy and inhibits the growth of bevacizumab-resistant glioblastoma. Cancer Res 73:3145\u20133154. https:\/\/doi.org\/10.1158\/0008-5472.CAN-13-0011","journal-title":"Cancer Res"},{"key":"5829_CR14","doi-asserted-by":"publisher","first-page":"4407","DOI":"10.7150\/ijbs.95350","volume":"20","author":"A Chaouat","year":"2024","unstructured":"Chaouat A, Kalechman Y, Hay O et al (2024) Inhibition of \u03b14\u03b21 integrin activity by small tellurium compounds regulates PD-L1 expression and enhances antitumor effects. Int J Biol Sci 20:4407\u20134423. https:\/\/doi.org\/10.7150\/ijbs.95350","journal-title":"Int J Biol Sci"},{"key":"5829_CR15","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.semcancer.2017.08.004","volume":"51","author":"A Chatterjee","year":"2018","unstructured":"Chatterjee A, Rodger EJ, Eccles MR (2018) Epigenetic drivers of tumourigenesis and cancer metastasis. Semin Cancer Biol 51:149\u2013159. https:\/\/doi.org\/10.1016\/j.semcancer.2017.08.004","journal-title":"Semin Cancer Biol"},{"key":"5829_CR16","doi-asserted-by":"publisher","first-page":"33384","DOI":"10.1039\/d4ra05244g","volume":"14","author":"PJ Chaudhari","year":"2024","unstructured":"Chaudhari PJ, Nemade AR, Shirkhedkar AA (2024) Recent updates on potential of VEGFR-2 small-molecule inhibitors as anticancer agents. RSC Adv 14:33384\u201333417. https:\/\/doi.org\/10.1039\/d4ra05244g","journal-title":"RSC Adv"},{"key":"5829_CR17","doi-asserted-by":"publisher","first-page":"56490","DOI":"10.18632\/oncotarget.17009","volume":"8","author":"L-M Chen","year":"2017","unstructured":"Chen L-M, Chai KX, Chen L-M, Chai KX (2017) Proteolytic cleavages in the extracellular domain of receptor tyrosine kinases by membrane-associated serine proteases. Oncotarget 8:56490\u201356505. https:\/\/doi.org\/10.18632\/oncotarget.17009","journal-title":"Oncotarget"},{"key":"5829_CR18","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.ccell.2019.01.007","volume":"35","author":"J Cooper","year":"2019","unstructured":"Cooper J, Giancotti FG (2019) Integrin signaling in cancer: mechanotransduction, stemness, epithelial plasticity, and therapeutic resistance. Cancer Cell 35:347\u2013367. https:\/\/doi.org\/10.1016\/j.ccell.2019.01.007","journal-title":"Cancer Cell"},{"key":"5829_CR19","doi-asserted-by":"publisher","first-page":"528","DOI":"10.2741\/2698","volume":"13","author":"MR Darragh","year":"2008","unstructured":"Darragh MR, Bhatt AS, Craik CS (2008) MT-SP1 proteolysis and regulation of cell-microenvironment interactions. Front Biosci (Elite Ed) 13:528\u2013539. https:\/\/doi.org\/10.2741\/2698","journal-title":"Front Biosci (Elite Ed)"},{"key":"5829_CR20","doi-asserted-by":"publisher","unstructured":"de la Cruz-Ojeda P, Schmid T, Boix L et al (2022) miR-200c-3p, miR-222\u20135p, and miR-512\u20133p constitute a biomarker signature of sorafenib effectiveness in advanced hepatocellular carcinoma. Cells 11. https:\/\/doi.org\/10.3390\/cells11172673","DOI":"10.3390\/cells11172673"},{"key":"5829_CR21","doi-asserted-by":"publisher","unstructured":"Dettmer K, N\u00fcrnberger N, Kaspar H et al (2010) Metabolite extraction from adherently growing mammalian cells for metabolomics studies: optimization of harvesting and extraction protocols. Anal Bioanal Chem 399:1127\u20131139. https:\/\/doi.org\/10.1007\/s00216-010-4425-x","DOI":"10.1007\/s00216-010-4425-x"},{"key":"5829_CR22","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1097\/00043426-199905000-00005","volume":"21","author":"SG DuBois","year":"1999","unstructured":"DuBois SG, Kalika Y, Lukens JN et al (1999) Metastatic sites in stage IV and IVS neuroblastoma correlate with age, tumor biology, and survival. J Pediatr Hematol Oncol 21:181\u2013189. https:\/\/doi.org\/10.1097\/00043426-199905000-00005","journal-title":"J Pediatr Hematol Oncol"},{"key":"5829_CR23","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.suc.2019.09.011","volume":"100","author":"LM Enomoto","year":"2020","unstructured":"Enomoto LM, Levine EA, Shen P, Votanopoulos KI (2020) Role of surgery for metastatic melanoma. Surg Clin North Am 100:127\u2013139. https:\/\/doi.org\/10.1016\/j.suc.2019.09.011","journal-title":"Surg Clin North Am"},{"key":"5829_CR24","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1158\/0008-5472.CAN-10-1660","volume":"71","author":"NY Frank","year":"2011","unstructured":"Frank NY, Schatton T, Kim S et al (2011) VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth. Cancer Res 71:1474\u20131485. https:\/\/doi.org\/10.1158\/0008-5472.CAN-10-1660","journal-title":"Cancer Res"},{"key":"5829_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2024.115153","author":"C Garbe","year":"2025","unstructured":"Garbe C, Amaral T, Peris K et al (2025) European consensus-based interdisciplinary guideline for melanoma. Part 2: treatment \u2013 update 2024. Eur J Cancer. https:\/\/doi.org\/10.1016\/j.ejca.2024.115153","journal-title":"Eur J Cancer"},{"key":"5829_CR26","doi-asserted-by":"publisher","unstructured":"Garci\u00e1-Caballero M, Van De Velde M, Blacher S et al (2017) Modeling pre-metastatic lymphvascular niche in the mouse ear sponge assay. Sci Rep 7:41494-. https:\/\/doi.org\/10.1038\/srep41494","DOI":"10.1038\/srep41494"},{"key":"5829_CR27","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1177\/0271678X18775887","volume":"39","author":"AB Garc\u00eda-Mart\u00edn","year":"2019","unstructured":"Garc\u00eda-Mart\u00edn AB, Zwicky P, Gruber T et al (2019) VLA-4 mediated adhesion of melanoma cells on the blood\u2013brain barrier is the critical cue for melanoma cell intercalation and barrier disruption. J Cereb Blood Flow Metab 39:1995\u20132010. https:\/\/doi.org\/10.1177\/0271678X18775887","journal-title":"J Cereb Blood Flow Metab"},{"key":"5829_CR28","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.jconrel.2019.10.028","volume":"316","author":"PPG Guimaraes","year":"2019","unstructured":"Guimaraes PPG, Zhang R, Spektor R et al (2019) Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening. J Control Release 316:404\u2013417. https:\/\/doi.org\/10.1016\/j.jconrel.2019.10.028","journal-title":"J Control Release"},{"key":"5829_CR29","doi-asserted-by":"publisher","unstructured":"Hamidi H, Ivaska J (2018) Every step of the way: integrins in cancer progression and metastasis. Nat Rev Cancer 18:533\u2013548. https:\/\/doi.org\/10.1038\/s41568-018-0038-z","DOI":"10.1038\/s41568-018-0038-z"},{"key":"5829_CR30","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1158\/2159-8290.CD-15-0012","volume":"5","author":"AS Harney","year":"2015","unstructured":"Harney AS, Arwert EN, Entenberg D et al (2015) Real-time imaging reveals local, transient vascular permeability, and tumor cell intravasation stimulated by TIE2hi macrophage\u2013derived VEGFA. Cancer Discov 5:932\u2013943. https:\/\/doi.org\/10.1158\/2159-8290.CD-15-0012","journal-title":"Cancer Discov"},{"key":"5829_CR31","doi-asserted-by":"publisher","DOI":"10.26508\/LSA.202000957","author":"RE Heap","year":"2021","unstructured":"Heap RE, Mar\u00edn-Rubio JL, Peltier J et al (2021) Proteomics characterisation of the L929 cell supernatant and its role in BMDM differentiation. Life Sci Alliance. https:\/\/doi.org\/10.26508\/LSA.202000957","journal-title":"Life Sci Alliance"},{"key":"5829_CR32","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.ccell.2015.03.008","volume":"27","author":"E Hirata","year":"2015","unstructured":"Hirata E, Girotti MR, Viros A et al (2015) Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin \u03b21\/FAK signaling. Cancer Cell 27:574\u2013588. https:\/\/doi.org\/10.1016\/j.ccell.2015.03.008","journal-title":"Cancer Cell"},{"key":"5829_CR33","doi-asserted-by":"publisher","first-page":"4360","DOI":"10.1167\/iovs.06-1234","volume":"48","author":"M Hollborn","year":"2007","unstructured":"Hollborn M, Stathopoulos C, Steffen A et al (2007) Positive feedback regulation between MMP-9 and VEGF in human RPE cells. Invest Ophthalmol Vis Sci 48:4360\u20134367. https:\/\/doi.org\/10.1167\/iovs.06-1234","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"5829_CR34","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1038\/LEU.2014.182","volume":"28","author":"YT Hsieh","year":"2014","unstructured":"Hsieh YT, Gang EJ, Shishido SN et al (2014) Effects of the small-molecule inhibitor of integrin \u03b14, TBC3486, on pre-B-ALL cells. Leukemia 28:2101\u20132104. https:\/\/doi.org\/10.1038\/LEU.2014.182","journal-title":"Leukemia"},{"key":"5829_CR35","doi-asserted-by":"publisher","unstructured":"Huang HL, Hsing HW, Lai TC et al (2010) Trypsin-induced proteome alteration during cell subculture in mammalian cells. J Biomed Sci 17:36. https:\/\/doi.org\/10.1186\/1423-0127-17-36","DOI":"10.1186\/1423-0127-17-36"},{"key":"5829_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112633","volume":"406","author":"W Huang","year":"2021","unstructured":"Huang W, Xing Y, Zhu L et al (2021) Sorafenib derivatives-functionalized gold nanoparticles confer protection against tumor angiogenesis and proliferation via suppression of EGFR and VEGFR-2. Exp Cell Res 406:112633. https:\/\/doi.org\/10.1016\/j.yexcr.2021.112633","journal-title":"Exp Cell Res"},{"key":"5829_CR37","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1177\/0271678X17703888","volume":"38","author":"A Jablonska","year":"2018","unstructured":"Jablonska A, Shea DJ, Cao S et al (2018) Overexpression of VLA-4 in glial-restricted precursors enhances their endothelial docking and induces diapedesis in a mouse stroke model. J Cereb Blood Flow Metab 38:835\u2013846. https:\/\/doi.org\/10.1177\/0271678X17703888","journal-title":"J Cereb Blood Flow Metab"},{"key":"5829_CR38","doi-asserted-by":"publisher","first-page":"E8685","DOI":"10.1073\/pnas.1701821114","volume":"114","author":"A Jahangiri","year":"2017","unstructured":"Jahangiri A, Nguyen A, Chandra A et al (2017) Cross-activating c-Met\/\u03b21 integrin complex drives metastasis and invasive resistance in cancer. Proc Natl Acad Sci U S A 114:E8685\u2013E8694. https:\/\/doi.org\/10.1073\/pnas.1701821114","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5829_CR39","doi-asserted-by":"publisher","first-page":"440","DOI":"10.4161\/cam.36224","volume":"8","author":"JEN Jonkman","year":"2014","unstructured":"Jonkman JEN, Cathcart JA, Xu F et al (2014) An introduction to the wound healing assay using live-cell microscopy. Cell Adh Migr 8:440\u2013451. https:\/\/doi.org\/10.4161\/cam.36224","journal-title":"Cell Adh Migr"},{"key":"5829_CR40","doi-asserted-by":"publisher","unstructured":"Jung O, Beauvais DM, Adams KM, Rapraeger AC (2019) VLA-4 phosphorylation during tumor and immune cell migration relies on its coupling to VEGFR2 and CXCR4 by syndecan-1. J Cell Sci 132. https:\/\/doi.org\/10.1242\/jcs.232645","DOI":"10.1242\/jcs.232645"},{"key":"5829_CR41","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/978-1-0716-3052-5_22","volume":"2644","author":"CR Justus","year":"2023","unstructured":"Justus CR, Marie MA, Sanderlin EJ, Yang LV (2023) Transwell in vitro cell migration and invasion assays. Methods Mol Biol 2644:349\u2013359. https:\/\/doi.org\/10.1007\/978-1-0716-3052-5_22","journal-title":"Methods Mol Biol"},{"key":"5829_CR42","doi-asserted-by":"publisher","unstructured":"Kadry YA, Calderwood DA (2020) Chapter 22: Structural and signaling functions of integrins. Biochimica et Biophysica Acta (BBA) - Biomembranes 1862:183206. https:\/\/doi.org\/10.1016\/j.bbamem.2020.183206","DOI":"10.1016\/j.bbamem.2020.183206"},{"key":"5829_CR43","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1001\/JAMADERMATOL.2016.5538","volume":"153","author":"C Karimkhani","year":"2017","unstructured":"Karimkhani C, Dellavalle RP, Coffeng LE et al (2017) Global skin disease morbidity and mortality: an update from the global burden of disease study 2013. JAMA Dermatol 153:406. https:\/\/doi.org\/10.1001\/JAMADERMATOL.2016.5538","journal-title":"JAMA Dermatol"},{"key":"5829_CR44","doi-asserted-by":"publisher","unstructured":"Karwaciak I, Sa\u0142kowska A, Kara\u015b K et al (2019) SIRT2 contributes to the resistance of melanoma cells to the multikinase inhibitor dasatinib. Cancers 11. https:\/\/doi.org\/10.3390\/cancers11050673","DOI":"10.3390\/cancers11050673"},{"key":"5829_CR45","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1212\/wnl.43.9.1728","volume":"43","author":"DK Kaufman","year":"1993","unstructured":"Kaufman DK, Kimmel DW, Parisi JE, Michels VV (1993) A familial syndrome with cutaneous malignant melanoma and cerebral astrocytoma. Neurology 43:1728\u20131731. https:\/\/doi.org\/10.1212\/wnl.43.9.1728","journal-title":"Neurology"},{"key":"5829_CR46","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1080\/14737140.2018.1489246","volume":"18","author":"EZ Keung","year":"2018","unstructured":"Keung EZ, Gershenwald JE (2018) The eighth edition American Joint Committee on Cancer (AJCC) melanoma staging system: implications for melanoma treatment and care. Expert Rev Anticancer Ther 18:775\u2013784. https:\/\/doi.org\/10.1080\/14737140.2018.1489246","journal-title":"Expert Rev Anticancer Ther"},{"key":"5829_CR47","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1002\/jcp.21029","volume":"212","author":"M Klemke","year":"2007","unstructured":"Klemke M, Weschenfelder T, Konstandin MH, Samstag Y (2007) High affinity interaction of integrin \u03b14\u03b21 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) enhances migration of human melanoma cells across activated endothelial cell layers. J Cell Physiol 212:368\u2013374. https:\/\/doi.org\/10.1002\/jcp.21029","journal-title":"J Cell Physiol"},{"key":"5829_CR48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111448","volume":"9","author":"MJ Kohr","year":"2014","unstructured":"Kohr MJ, Murphy E, Steenbergen C (2014) Glyceraldehyde-3-phosphate dehydrogenase acts as a mitochondrial trans-S-nitrosylase in the heart. PLoS ONE 9:e111448. https:\/\/doi.org\/10.1371\/journal.pone.0111448","journal-title":"PLoS ONE"},{"key":"5829_CR49","doi-asserted-by":"publisher","unstructured":"Koizumi K, Shintani T, Hayashido Y et al (2022) VEGF-A promotes the motility of human melanoma cells through the VEGFR1\u2013PI3K\/Akt signaling pathway. In Vitro Cell Dev Biol - Animal 58:758\u2013770. https:\/\/doi.org\/10.1007\/s11626-022-00717-3","DOI":"10.1007\/s11626-022-00717-3"},{"key":"5829_CR50","doi-asserted-by":"publisher","unstructured":"Kozlova NI, Morozevich GE, Ushakova NA, Berman AE (2018) Implication of integrin \u03b12\u03b21 in proliferation and invasion of human breast carcinoma and melanoma cells: noncanonical function of Akt protein kinase. Biochemistry (Moscow) 2018 83:6 83:738\u2013745. https:\/\/doi.org\/10.1134\/S0006297918060111","DOI":"10.1134\/S0006297918060111"},{"key":"5829_CR51","doi-asserted-by":"publisher","first-page":"24345","DOI":"10.18632\/aging.202243","volume":"12","author":"NI Kozlova","year":"2020","unstructured":"Kozlova NI, Morozevich GE, Gevorkian NM, Berman AE (2020) Implication of integrins \u03b13\u03b21 and \u03b15\u03b21 in invasion and anoikis of SK-Mel-147 human melanoma cells: non-canonical functions of protein kinase Akt. Aging 12:24345\u201324356. https:\/\/doi.org\/10.18632\/aging.202243","journal-title":"Aging"},{"key":"5829_CR52","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1177\/1947601911423654","volume":"2","author":"BL Krock","year":"2011","unstructured":"Krock BL, Skuli N, Simon MC (2011) Hypoxia-induced angiogenesis: good and evil. Genes Cancer 2:1117\u20131133. https:\/\/doi.org\/10.1177\/1947601911423654","journal-title":"Genes Cancer"},{"key":"5829_CR53","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.cell.2016.11.037","volume":"168","author":"AW Lambert","year":"2017","unstructured":"Lambert AW, Pattabiraman DR, Weinberg RA (2017) Emerging biological principles of metastasis. Cell 168:670\u2013691. https:\/\/doi.org\/10.1016\/j.cell.2016.11.037","journal-title":"Cell"},{"key":"5829_CR54","doi-asserted-by":"publisher","first-page":"7758","DOI":"10.1074\/jbc.M611327200","volume":"282","author":"M Laram\u00e9","year":"2007","unstructured":"Laram\u00e9 M, Chabot C, Cloutier M et al (2007) The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation. J Biol Chem 282:7758\u20137769. https:\/\/doi.org\/10.1074\/jbc.M611327200","journal-title":"J Biol Chem"},{"key":"5829_CR55","doi-asserted-by":"publisher","first-page":"i7","DOI":"10.1093\/noajnl\/vdae090.019","volume":"6","author":"V Law","year":"2024","unstructured":"Law V, Bayle S, Duckett D, Forsyth P (2024) BSLM-09 identification of drugs with selective activity against melanoma-associated leptomeningeal disease using patient-derived circulating tumor cells. Neurooncol Adv 6:i7\u2013i7. https:\/\/doi.org\/10.1093\/noajnl\/vdae090.019","journal-title":"Neurooncol Adv"},{"key":"5829_CR56","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1046\/j.1440-1711.2003.t01-1-01175.x","volume":"81","author":"E Leung","year":"2003","unstructured":"Leung E, Kanwar RK, Kanwar JR, Krissansen GW (2003) Mucosal vascular addressin cell adhesion molecule-1 is expressed outside the endothelial lineage on fibroblasts and melanoma cells. Immunol Cell Biol 81:320\u2013327. https:\/\/doi.org\/10.1046\/j.1440-1711.2003.t01-1-01175.x","journal-title":"Immunol Cell Biol"},{"key":"5829_CR57","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1016\/j.ajpath.2012.07.009","volume":"181","author":"S Liu","year":"2012","unstructured":"Liu S, Tetzlaff MT, Cui R, Xu X (2012) MiR-200c inhibits melanoma progression and drug resistance through down-regulation of Bmi-1. Am J Pathol 181:1823\u20131835. https:\/\/doi.org\/10.1016\/j.ajpath.2012.07.009","journal-title":"Am J Pathol"},{"key":"5829_CR58","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1111\/pcmr.12379","volume":"28","author":"S Liu","year":"2015","unstructured":"Liu S, Tetzlaff MT, Wang T et al (2015) MiR-200c\/Bmi1 axis and epithelial-mesenchymal transition contribute to acquired resistance to BRAF inhibitor treatment. Pigment Cell Melanoma Res 28:431\u2013441. https:\/\/doi.org\/10.1111\/pcmr.12379","journal-title":"Pigment Cell Melanoma Res"},{"key":"5829_CR59","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.bbrc.2017.07.096","volume":"491","author":"TN Lu","year":"2017","unstructured":"Lu TN, Ganganna B, Pham TT et al (2017) Antitumor effect of the integrin \u03b14 signaling inhibitor JK273 in non-small cell lung cancer NCI-H460 cells. Biochem Biophys Res Commun 491:355\u2013360. https:\/\/doi.org\/10.1016\/j.bbrc.2017.07.096","journal-title":"Biochem Biophys Res Commun"},{"key":"5829_CR60","doi-asserted-by":"publisher","unstructured":"Lu F, Zhu L, Bromberger T et al (2022) Mechanism of integrin activation by talin and its cooperation with kindlin. Nat Commun 13:2362-. https:\/\/doi.org\/10.1038\/s41467-022-30117-w","DOI":"10.1038\/s41467-022-30117-w"},{"key":"5829_CR61","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1056\/NEJMC0706103","volume":"358","author":"JT Mullen","year":"2008","unstructured":"Mullen JT, Vartanian TK, Atkins MB (2008) Melanoma complicating treatment with natalizumab for multiple sclerosis. N Engl J Med 358:647\u2013648. https:\/\/doi.org\/10.1056\/NEJMC0706103","journal-title":"N Engl J Med"},{"key":"5829_CR62","doi-asserted-by":"publisher","unstructured":"Nagy \u00c1G, Sz\u00e9k\u00e1cs I, Bony\u00e1r A, Horvath R (2022) Simple and automatic monitoring of cancer cell invasion into an epithelial monolayer using label-free holographic microscopy. Sci Rep 12:10111-. https:\/\/doi.org\/10.1038\/s41598-022-14034-y","DOI":"10.1038\/s41598-022-14034-y"},{"key":"5829_CR63","doi-asserted-by":"publisher","unstructured":"Nakao M, Kim K, Nagase K et al (2019) Phenotypic traits of mesenchymal stem cell sheets fabricated by temperature-responsive cell culture plate: structural characteristics of MSC sheets. Stem Cell Res Ther 10:353-. https:\/\/doi.org\/10.1186\/s13287-019-1431-6","DOI":"10.1186\/s13287-019-1431-6"},{"key":"5829_CR64","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.3892\/or.2012.1963","volume":"28","author":"A Nasulewicz-Goldeman","year":"2012","unstructured":"Nasulewicz-Goldeman A, Uszczy\u0144ska B, Szczaurska-Nowak K, Wietrzyk J (2012) SiRNA-mediated silencing of integrin \u03b23 expression inhibits the metastatic potential of B16 melanoma cells. Oncol Rep 28:1567\u20131573. https:\/\/doi.org\/10.3892\/or.2012.1963","journal-title":"Oncol Rep"},{"key":"5829_CR65","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1016\/j.bpj.2019.04.028","volume":"116","author":"S Nehls","year":"2019","unstructured":"Nehls S, N\u00f6ding H, Karsch S et al (2019) Stiffness of MDCK II cells depends on confluency and cell size. Biophys J 116:2204\u20132211. https:\/\/doi.org\/10.1016\/j.bpj.2019.04.028","journal-title":"Biophys J"},{"key":"5829_CR66","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1182\/blood-2007-12-129395","volume":"112","author":"HT Ngo","year":"2008","unstructured":"Ngo HT, Leleu X, Lee J et al (2008) SDF-1\/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom macroglobulinemia. Blood 112:150\u2013158. https:\/\/doi.org\/10.1182\/blood-2007-12-129395","journal-title":"Blood"},{"key":"5829_CR67","doi-asserted-by":"publisher","unstructured":"Nieberler M, Reuning U, Reichart F et al (2017) Exploring the role of RGD-recognizing integrins in cancer. Cancers 9. https:\/\/doi.org\/10.3390\/cancers9090116","DOI":"10.3390\/cancers9090116"},{"key":"5829_CR68","doi-asserted-by":"publisher","unstructured":"Obeng G, Park EJ, Appiah MG et al (2021) miRNA-200c-3p targets talin-1 to regulate integrin-mediated cell adhesion. Sci Rep 11:21597. https:\/\/doi.org\/10.1038\/s41598-021-01143-3","DOI":"10.1038\/s41598-021-01143-3"},{"key":"5829_CR69","doi-asserted-by":"publisher","unstructured":"Orzan OA, Giurc\u0103neanu C, Dima B et al (2023) Cutaneous melanoma and glioblastoma multiforme association\u2014case presentation and literature review. Diagnostics 13. https:\/\/doi.org\/10.3390\/diagnostics13061046","DOI":"10.3390\/diagnostics13061046"},{"key":"5829_CR70","doi-asserted-by":"publisher","unstructured":"Pang X, He X, Qiu Z, et al (2023) Targeting integrin pathways: mechanisms and advances in therapy. Signal Transduct Targeted Ther 8:1. https:\/\/doi.org\/10.1038\/s41392-022-01259-6","DOI":"10.1038\/s41392-022-01259-6"},{"key":"5829_CR71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115402","volume":"9","author":"Z Qin","year":"2014","unstructured":"Qin Z, Robichaud P, He T et al (2014) Oxidant exposure induces cysteine-rich protein 61 (CCN1) via c-Jun\/AP-1 to reduce collagen expression in human dermal fibroblasts. PLoS ONE 9:e115402. https:\/\/doi.org\/10.1371\/journal.pone.0115402","journal-title":"PLoS ONE"},{"key":"5829_CR72","doi-asserted-by":"publisher","first-page":"482","DOI":"10.2353\/ajpath.2006.060128","volume":"169","author":"TH Quan","year":"2006","unstructured":"Quan TH, He TY, Shao Y et al (2006) Elevated cysteine-rich 61 mediates aberrant collagen homeostasis in chronologically aged and photoaged human skin. Am J Pathol 169:482\u2013490. https:\/\/doi.org\/10.2353\/ajpath.2006.060128","journal-title":"Am J Pathol"},{"key":"5829_CR73","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1002\/CAM4.1098","volume":"6","author":"RA Sabol","year":"2017","unstructured":"Sabol RA, Noxon V, Sartor O et al (2017) Melanoma complicating treatment with natalizumab for multiple sclerosis: a report from the Southern Network on Adverse Reactions (SONAR). Cancer Med 6:1541. https:\/\/doi.org\/10.1002\/CAM4.1098","journal-title":"Cancer Med"},{"issue":"4","key":"5829_CR74","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s10555-014-9545-x","volume":"34","author":"M Schlesinger","year":"2015","unstructured":"Schlesinger M, Bendas G (2015) Contribution of very late antigen-4 (VLA-4) integrin to cancer progression and metastasis. Cancer Metastasis Rev 34(4):575\u2013591. https:\/\/doi.org\/10.1007\/s10555-014-9545-x","journal-title":"Cancer Metastasis Rev"},{"key":"5829_CR75","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.thromres.2011.10.023","volume":"129","author":"M Schlesinger","year":"2012","unstructured":"Schlesinger M, Schmitz P, Zeisig R et al (2012) The inhibition of the integrin VLA-4 in MV3 melanoma cell binding by non-anticoagulant heparin derivatives. Thromb Res 129:603\u2013610. https:\/\/doi.org\/10.1016\/j.thromres.2011.10.023","journal-title":"Thromb Res"},{"key":"5829_CR76","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1200\/JCO.2003.10.108","volume":"21","author":"NH Segal","year":"2003","unstructured":"Segal NH, Pavlidis P, Noble WS et al (2003) Classification of clear-cell sarcoma as a subtype of melanoma by genomic profiling. J Clin Oncol 21:1775\u20131781. https:\/\/doi.org\/10.1200\/JCO.2003.10.108","journal-title":"J Clin Oncol"},{"key":"5829_CR77","doi-asserted-by":"publisher","first-page":"4794","DOI":"10.1200\/JCO.23.01136;REQUESTEDJOURNAL:JOURNAL:JCO;WGROUP:STRING:PUBLICATION","volume":"41","author":"R Seth","year":"2023","unstructured":"Seth R, Agarwala SS, Messersmith H et al (2023) Systemic therapy for melanoma: ASCO guideline update. J Clin Oncol 41:4794\u20134820. https:\/\/doi.org\/10.1200\/JCO.23.01136;REQUESTEDJOURNAL:JOURNAL:JCO;WGROUP:STRING:PUBLICATION","journal-title":"J Clin Oncol"},{"key":"5829_CR78","doi-asserted-by":"publisher","first-page":"50","DOI":"10.2174\/1389200221666201019143252","volume":"22","author":"AA Shah","year":"2020","unstructured":"Shah AA, Kamal MA, Akhtar S (2020) Tumor angiogenesis and VEGFR-2: mechanism, pathways and current biological therapeutic interventions. Curr Drug Metab 22:50\u201359. https:\/\/doi.org\/10.2174\/1389200221666201019143252","journal-title":"Curr Drug Metab"},{"key":"5829_CR79","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3322\/caac.21871","volume":"75","author":"RL Siegel","year":"2025","unstructured":"Siegel RL, Kratzer TB, Giaquinto AN et al (2025) Cancer statistics, 2025. CA Cancer J Clin 75:10\u201345. https:\/\/doi.org\/10.3322\/caac.21871","journal-title":"CA Cancer J Clin"},{"key":"5829_CR80","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1039\/c5fo00760g","volume":"7","author":"L Song","year":"2016","unstructured":"Song L, Chang J, Li Z (2016) A serine protease extracted from Trichosanthes kirilowii induces apoptosis via the PI3K\/AKT-mediated mitochondrial pathway in human colorectal adenocarcinoma cells. Food Funct 7:843\u2013854. https:\/\/doi.org\/10.1039\/c5fo00760g","journal-title":"Food Funct"},{"key":"5829_CR81","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/ncponc1066","volume":"5","author":"PS Steeg","year":"2008","unstructured":"Steeg PS, Theodorescu D (2008) Metastasis: a therapeutic target for cancer. Nat Clin Pract Oncol 5:206\u2013219. https:\/\/doi.org\/10.1038\/ncponc1066","journal-title":"Nat Clin Pract Oncol"},{"key":"5829_CR82","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1124\/mol.118.113027","volume":"94","author":"N Stojanovic","year":"2018","unstructured":"Stojanovic N, Dekanic A, Parad\u017eik M et al (2018) Differential effects of integrin av knockdown and cilengitide on sensitization of triple-negative breast cancer and melanoma cells to microtubule poisons. Mol Pharmacol 94:1334\u20131351. https:\/\/doi.org\/10.1124\/mol.118.113027","journal-title":"Mol Pharmacol"},{"key":"5829_CR83","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1002\/ptr.6569","volume":"34","author":"X Sun","year":"2020","unstructured":"Sun X, Xu X, Song L (2020) TKP, a serine protease extracted from Trichosanthes kirilowii, inhibits the migration and invasion of colorectal adenocarcinoma cells by targeting Wnt\/\u03b2-catenin and Hedgehog\/Gli1 signalings. Phytother Res 34:867\u2013878. https:\/\/doi.org\/10.1002\/ptr.6569","journal-title":"Phytother Res"},{"key":"5829_CR84","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/978-1-4939-6863-3_12","volume":"1579","author":"RN Tajhya","year":"2017","unstructured":"Tajhya RN, Patel RS, Beeton C (2017) Detection of matrix metalloproteinases by Zymography. Methods Mol Biol 1579:231\u2013244. https:\/\/doi.org\/10.1007\/978-1-4939-6863-3_12","journal-title":"Methods Mol Biol"},{"key":"5829_CR85","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1182\/blood-2010-08-302240","volume":"118","author":"Y Takeda","year":"2011","unstructured":"Takeda Y, Li Q, Kazarov AR et al (2011) Diminished metastasis in tetraspanin CD151\u2013knockout mice. Blood 118:464\u2013472. https:\/\/doi.org\/10.1182\/blood-2010-08-302240","journal-title":"Blood"},{"key":"5829_CR86","doi-asserted-by":"publisher","first-page":"7234","DOI":"10.1158\/1078-0432.CCR-05-0683","volume":"11","author":"D Talantov","year":"2005","unstructured":"Talantov D, Mazumder A, Yu JX et al (2005) Novel genes associated with malignant melanoma but not benign melanocytic lesions. Clin Cancer Res 11:7234\u20137242. https:\/\/doi.org\/10.1158\/1078-0432.CCR-05-0683","journal-title":"Clin Cancer Res"},{"key":"5829_CR87","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1111\/j.1365-2133.2005.06765.x","volume":"153","author":"J Tao","year":"2005","unstructured":"Tao J, Tu YT, Huang CZ et al (2005) Inhibiting the growth of malignant melanoma by blocking the expression of vascular endothelial growth factor using an RNA interference approach. Br J Dermatol 153:715\u2013724. https:\/\/doi.org\/10.1111\/j.1365-2133.2005.06765.x","journal-title":"Br J Dermatol"},{"issue":"6","key":"5829_CR88","doi-asserted-by":"publisher","first-page":"827","DOI":"10.3892\/ol.2021.13089","volume":"22","author":"T Takeda","year":"2021","unstructured":"Takeda T, Tsubaki M, Kato N, Genno S, Ichimura E, Enomoto A, Imano M, Satou T, Nishida S (2021) Sorafenib treatment of metastatic melanoma with c-Kit aberration reduces tumor growth and promotes survival. Oncol Lett 22(6):827. https:\/\/doi.org\/10.3892\/ol.2021.13089","journal-title":"Oncol Lett"},{"key":"5829_CR89","doi-asserted-by":"publisher","first-page":"4813","DOI":"10.1182\/blood-2004-10-4054","volume":"105","author":"KJ Till","year":"2005","unstructured":"Till KJ, Spiller DG, Harris RJ et al (2005) CLL, but not normal, B cells are dependent on autocrine VEGF and \u03b14\u03b21 integrin for chemokine-induced motility on and through endothelium. Blood 105:4813\u20134819. https:\/\/doi.org\/10.1182\/blood-2004-10-4054","journal-title":"Blood"},{"key":"5829_CR90","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/jid.2013.342","volume":"134","author":"M Valc\u00e1rcel","year":"2014","unstructured":"Valc\u00e1rcel M, Carrascal T, Crende O, Vidal-Vanaclocha F (2014) IL-18 regulates melanoma VLA-4 integrin activation through a hierarchized sequence of inflammatory factors. J Invest Dermatol 134:470\u2013480. https:\/\/doi.org\/10.1038\/jid.2013.342","journal-title":"J Invest Dermatol"},{"key":"5829_CR91","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1097\/CMR.0000000000000322","volume":"27","author":"L Vizkeleti","year":"2017","unstructured":"Vizkeleti L, Kiss T, Koroknai V et al (2017) Altered integrin expression patterns shown by microarray in human cutaneous melanoma. Melanoma Res 27:180\u2013188. https:\/\/doi.org\/10.1097\/CMR.0000000000000322","journal-title":"Melanoma Res"},{"key":"5829_CR92","doi-asserted-by":"publisher","first-page":"S16","DOI":"10.1007\/s002800170004","volume":"47","author":"M Wald","year":"2001","unstructured":"Wald M, Olej\u00e1r T, \u0160ebkov\u00e1 V et al (2001) Mixture of trypsin, chymotrypsin and papain reduces formation of metastases and extends survival time of C57Bl6 mice with syngeneic melanoma B16. Cancer Chemotherapy and Pharmacology, Supplement 47:S16\u2013S22. https:\/\/doi.org\/10.1007\/s002800170004","journal-title":"Cancer Chemother Pharmacol"},{"key":"5829_CR93","doi-asserted-by":"publisher","DOI":"10.7554\/ELIFE.62781","author":"SM Walsh","year":"2021","unstructured":"Walsh SM, Sheridan RM, Lucas ED et al (2021) Molecular tracking devices quantify antigen distribution and archiving in the murine lymph node. Elife. https:\/\/doi.org\/10.7554\/ELIFE.62781","journal-title":"Elife"},{"key":"5829_CR94","first-page":"1985","volume":"8","author":"QW Wu","year":"2016","unstructured":"Wu QW (2016) Serpine2, a potential novel target for combating melanoma metastasis. Am J Transl Res 8:1985","journal-title":"Am J Transl Res"},{"key":"5829_CR95","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/jmi.13053","volume":"284","author":"J Yan","year":"2021","unstructured":"Yan J, Xie C, Zhu J et al (2021) Effect of trypsin concentration on living SMCC-7721 cells studied by atomic force microscopy. J Microsc 284:203\u2013213. https:\/\/doi.org\/10.1111\/jmi.13053","journal-title":"J Microsc"},{"key":"5829_CR96","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1083\/jcb.200403174","volume":"165","author":"J Yang","year":"2004","unstructured":"Yang J, Price MA, Neudauer CL et al (2004) Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms. J Cell Biol 165:881\u2013891. https:\/\/doi.org\/10.1083\/jcb.200403174","journal-title":"J Cell Biol"},{"key":"5829_CR97","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120815","volume":"10","author":"SA Young","year":"2015","unstructured":"Young SA, McCabe KE, Bartakova A et al (2015) Integrin \u03b14 enhances metastasis and may be associated with poor prognosis in MYCNlow neuroblastoma. PLoS ONE 10:e0120815. https:\/\/doi.org\/10.1371\/journal.pone.0120815","journal-title":"PLoS ONE"},{"key":"5829_CR98","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.canlet.2015.01.032","volume":"360","author":"XP Zhao","year":"2015","unstructured":"Zhao XP, Wang M, Song Y et al (2015) Membrane microvesicles as mediators for melanoma-fibroblasts communication: roles of the VCAM-1\/VLA-4 axis and the ERK1\/2 signal pathway. Cancer Lett 360:125\u2013133. https:\/\/doi.org\/10.1016\/j.canlet.2015.01.032","journal-title":"Cancer Lett"},{"issue":"1","key":"5829_CR99","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0911-3","volume":"37","author":"X Zhou","year":"2018","unstructured":"Zhou X, Yan T, Huang C et al (2018) Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1\/JAK2\/STAT3 signaling pathway. J Exp Clin Cancer Res 37(1):242-. https:\/\/doi.org\/10.1186\/s13046-018-0911-3","journal-title":"J Exp Clin Cancer Res"},{"key":"5829_CR100","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.canlet.2019.12.039","volume":"473","author":"Z Zhou","year":"2020","unstructured":"Zhou Z, Zhou Q, Wu X et al (2020) VCAM-1 secreted from cancer-associated fibroblasts enhances the growth and invasion of lung cancer cells through AKT and MAPK signaling. Cancer Lett 473:62\u201373. https:\/\/doi.org\/10.1016\/j.canlet.2019.12.039","journal-title":"Cancer Lett"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05829-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05829-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05829-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T01:00:27Z","timestamp":1787360427000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05829-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,22]]},"references-count":100,"alternative-id":["5829"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05829-1","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,22]]},"assertion":[{"value":"28 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}