{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:14:16Z","timestamp":1788495256938,"version":"build-2803163510"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"DOI":"10.1007\/s00210-026-05879-5","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:45:30Z","timestamp":1788493530000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Iron chelation therapy and splenomegaly severity in transfusion dependent beta thalassemia major: assessment of ferritin patterns and clinical outcomes"],"prefix":"10.1007","author":[{"given":"Sidra","family":"Jamil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2648-3915","authenticated-orcid":false,"given":"Narendar","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4030-5362","authenticated-orcid":false,"given":"Shaib","family":"Muhammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reham","family":"Bakhsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azfar Athar","family":"Ishaqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tauqeer Hussain","family":"Mallhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Orayj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"issue":"21","key":"5879_CR1","doi-asserted-by":"publisher","first-page":"5309","DOI":"10.1182\/blood.V118.21.5309.5309","volume":"118","author":"SH Ansari","year":"2011","unstructured":"Ansari SH, Shamsi TS, Bohray M, Khan MT, Farzana T, Perveen K et al (2011) Molecular epidemiology of \u03b2-thalassemia in Pakistan: far reaching implications. Blood 118(21):5309","journal-title":"Blood"},{"key":"5879_CR2","doi-asserted-by":"publisher","first-page":"7515","DOI":"10.2147\/ijgm.s338114","volume":"14","author":"TD Atmakusuma","year":"2021","unstructured":"Atmakusuma TD, Saragih EYP, Rajabto W (2021) Achievement of pre- and post-transfusion hemoglobin levels in adult transfusion-dependent beta thalassemia: associated factors and relationship to reduction of spleen enlargement. Int J Gen Med 14:7515\u20137521. https:\/\/doi.org\/10.2147\/ijgm.s338114","journal-title":"Int J Gen Med"},{"key":"5879_CR3","volume-title":"Guidelines for the management of transfusion dependent thalassaemia (TDT)","author":"MD Cappellini","year":"2014","unstructured":"Cappellini MD, Cohen A, Porter J, Taher A, Viprakasit V (2014) Guidelines for the management of transfusion dependent thalassaemia (TDT). Thalassaemia International Federation, Nicosia (Cyprus)"},{"issue":"1","key":"5879_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-22234-9","volume":"12","author":"H Darvishi-Khezri","year":"2022","unstructured":"Darvishi-Khezri H, Aliasgharian A, Naderisorki M, Kosaryan M, Ghazaiean M, Fallah H et al (2022) Ferritin thresholds for cardiac and liver hemosiderosis in \u03b2-thalassemia patients: a diagnostic accuracy study. Sci Rep 12(1):17996","journal-title":"Sci Rep"},{"issue":"10","key":"5879_CR5","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1111\/j.1537-2995.2007.01416.x","volume":"47","author":"TE Delea","year":"2007","unstructured":"Delea TE, Edelsberg J, Sofrygin O, Thomas SK, Baladi JF, Phatak PD et al (2007) Consequences and costs of noncompliance with iron chelation therapy in patients with transfusion\u2010dependent thalassemia: a literature review. Transfusion 47(10):1919\u20131929","journal-title":"Transfusion"},{"issue":"8","key":"5879_CR6","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000732","volume":"6","author":"D Farmakis","year":"2021","unstructured":"Farmakis D, Porter J, Taher A, Cappellini MD, Angastiniotis M, Eleftheriou A (2021) 2021 Thalassaemia International Federation guidelines for the management of transfusion-dependent thalassemia. Hemasphere 6(8):e732","journal-title":"Hemasphere"},{"issue":"1","key":"5879_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-11","volume":"5","author":"R Galanello","year":"2010","unstructured":"Galanello R, Origa R (2010) Beta-thalassemia. Orphanet J Rare Dis 5(1):11","journal-title":"Orphanet J Rare Dis"},{"key":"5879_CR8","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012349.pub3","author":"LJ Geneen","year":"2023","unstructured":"Geneen LJ, Dor\u00e9e C, Estcourt LJ (2023) Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia. Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.CD012349.pub3","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"5879_CR9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-34205-9","volume":"13","author":"MJ Hossain","year":"2023","unstructured":"Hossain MJ, Islam MW, Munni UR, Gulshan R, Mukta SA, Miah MS et al (2023) Health-related quality of life among thalassemia patients in Bangladesh using the SF-36 questionnaire. Sci Rep 13(1):7734","journal-title":"Sci Rep"},{"issue":"4","key":"5879_CR10","first-page":"187","volume":"6","author":"S Katal","year":"2023","unstructured":"Katal S, Mahajan S, Pandita P, Uppal A, Sharma R, Digra SK et al (2023) Splenomegaly and cholelithiasis in patients with thalassemia major and thalassemia intermedia. Int J 6(4):187","journal-title":"Int J"},{"issue":"5","key":"5879_CR11","doi-asserted-by":"publisher","first-page":"524","DOI":"10.3390\/healthcare12050524","volume":"12","author":"P Klonizakis","year":"2024","unstructured":"Klonizakis P, Roy N, Papatsouma I, Mainou M, Christodoulou I, Pantelidou D, Kokkota S, Diamantidis M, Kourakli A, Lazaris V et al (2024) A cross-sectional, multicentric, disease-specific, health-related quality of life study in greek transfusion dependent thalassemia patients. Healthcare 12(5):524. https:\/\/doi.org\/10.3390\/healthcare12050524","journal-title":"Healthcare"},{"issue":"3","key":"5879_CR12","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.blre.2008.08.001","volume":"23","author":"MA Knovich","year":"2009","unstructured":"Knovich MA, Storey JA, Coffman LG, Torti SV, Torti FM (2009) Ferritin for the clinician. Blood Rev 23(3):95\u2013104","journal-title":"Blood Rev"},{"issue":"3","key":"5879_CR13","doi-asserted-by":"publisher","first-page":"615","DOI":"10.5455\/rmj.20241224043952","volume":"50","author":"KA Meghji","year":"2025","unstructured":"Meghji KA, Siyal AR, Memon HA, Wadhwani P, Khan A, Memon MU (2025) Impact of transfusion frequency and iron overload on splenomegaly in \u03b2-thalassemia major: a cross-sectional study. Rawal Med J 50(3):615","journal-title":"Rawal Med J"},{"issue":"7","key":"5879_CR14","doi-asserted-by":"publisher","first-page":"2973","DOI":"10.1182\/blood-2008-04-148767","volume":"112","author":"LJ Noetzli","year":"2008","unstructured":"Noetzli LJ, Carson SM, Nord AS, Coates TD, Wood JC (2008) Longitudinal analysis of heart and liver iron in thalassemia major. Blood 112(7):2973\u20132978","journal-title":"Blood"},{"issue":"22","key":"5879_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228771","volume":"21","author":"VM Pinto","year":"2020","unstructured":"Pinto VM, Forni GL (2020) Management of iron overload in beta-thalassemia patients: clinical practice update based on case series. Int J Mol Sci 21(22):8771","journal-title":"Int J Mol Sci"},{"issue":"1","key":"5879_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-4-287","volume":"4","author":"H Riaz","year":"2011","unstructured":"Riaz H, Riaz T, Khan MU, Aziz S, Ullah F, Rehman A et al (2011) Serum ferritin levels, socio-demographic factors and desferrioxamine therapy in multi-transfused thalassemia major patients at a government tertiary care hospital of Karachi, Pakistan. BMC Res Notes 4(1):287","journal-title":"BMC Res Notes"},{"issue":"4","key":"5879_CR17","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3390\/thalassrep14040010","volume":"14","author":"IZ Sadiq","year":"2024","unstructured":"Sadiq IZ, Abubakar FS, Usman HS, Abdullahi AD, Ibrahim B, Kastayal BS et al (2024) Thalassemia: pathophysiology, diagnosis, and advances in treatment. Thalass Rep 14(4):81\u2013102","journal-title":"Thalass Rep"},{"issue":"4","key":"5879_CR18","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2020.72","volume":"35","author":"RK Sadullah","year":"2020","unstructured":"Sadullah RK, Atroshi SD, Al-Allawi NA (2020) Complications and challenges in the management of Iraqi patients with \u03b2-thalassemia major: a single-center experience. Oman Med J 35(4):e152","journal-title":"Oman Med J"},{"issue":"2","key":"5879_CR19","doi-asserted-by":"publisher","first-page":"94","DOI":"10.4103\/0973-6247.67029","volume":"4","author":"N Shah","year":"2010","unstructured":"Shah N, Mishra A, Chauhan D, Vora C, Shah N (2010) Study on effectiveness of transfusion program in thalassemia major patients receiving multiple blood transfusions at a transfusion centre in Western India. Asian J Transfus Sci 4(2):94\u201398","journal-title":"Asian J Transfus Sci"},{"issue":"1","key":"5879_CR20","doi-asserted-by":"publisher","first-page":"27","DOI":"10.18502\/ijhoscr.v15i1.5247","volume":"15","author":"S Sidhu","year":"2021","unstructured":"Sidhu S, Kakkar S, Dewan P, Bansal N, Sobti PC (2021) Adherence to iron chelation therapy and its determinants. Int J Hematol Oncol Stem Cell Res 15(1):27","journal-title":"Int J Hematol Oncol Stem Cell Res"},{"issue":"1","key":"5879_CR21","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1080\/07853890.2022.2048065","volume":"54","author":"EA Subahi","year":"2022","unstructured":"Subahi EA, Ata F, Choudry H, Iqbal P, AlHiyari MA, Soliman AT et al (2022) Extramedullary haematopoiesis in patients with transfusion dependent \u03b2-thalassaemia (TDT): a systematic review. Ann Med 54(1):764\u2013774","journal-title":"Ann Med"},{"issue":"8","key":"5879_CR22","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1056\/NEJMra2021838","volume":"384","author":"AT Taher","year":"2021","unstructured":"Taher AT, Musallam KM, Cappellini MD (2021) \u03b2-thalassemias. N Engl J Med 384(8):727\u2013743","journal-title":"N Engl J Med"},{"issue":"2","key":"5879_CR23","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.hoc.2022.12.001","volume":"37","author":"N Tesio","year":"2023","unstructured":"Tesio N, Bauer DE (2023) Molecular basis and genetic modifiers of thalassemia. Hematol Oncol Clin North Am 37(2):273\u2013299","journal-title":"Hematol Oncol Clin North Am"},{"issue":"5","key":"5879_CR24","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1002\/ajh.21670","volume":"85","author":"F Trachtenberg","year":"2010","unstructured":"Trachtenberg F, Foote D, Martin M, Carson S, Coates T, Beams O et al (2010) Pain as an emergent issue in thalassemia. Am J Hematol 85(5):367\u2013370","journal-title":"Am J Hematol"},{"issue":"3","key":"5879_CR25","doi-asserted-by":"publisher","first-page":"e162","DOI":"10.1097\/MPH.0000000000000307","volume":"37","author":"VN Tubman","year":"2015","unstructured":"Tubman VN, Fung EB, Vogiatzi M, Thompson AA, Rogers ZR, Neufeld EJ et al (2015) Guidelines for the standard monitoring of patients with thalassemia: report of the thalassemia longitudinal cohort. J Pediatr Hematol Oncol 37(3):e162\u2013e169","journal-title":"J Pediatr Hematol Oncol"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05879-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05879-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05879-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:45:31Z","timestamp":1788493531000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05879-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,4]]},"references-count":25,"alternative-id":["5879"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05879-5","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,4]]},"assertion":[{"value":"28 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declared that \u201cNo Generative AI and AI-assisted technologies have been used in this research\u201d.","order":1,"name":"Ethics","label":"Declaration of generative AI and AI-assisted technologies","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}