{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:02:40Z","timestamp":1790614960091,"version":"4.1.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"DOI":"10.1007\/s00210-026-05915-4","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:17:12Z","timestamp":1790565432000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective effect of dapagliflozin against phenytoin-induced cerebellar dysfunction and histological alterations in rats: the role of SIRT1\/Nrf2\/HO-1 pathway"],"prefix":"10.1007","author":[{"given":"Heba Fathy","family":"El-Domiaty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa","family":"Eldesouky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2871-5190","authenticated-orcid":false,"given":"Heba Rady","family":"Salem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"5915_CR1","doi-asserted-by":"publisher","first-page":"96","DOI":"10.14581\/jer.20016","volume":"10","author":"H Algahtani","year":"2020","unstructured":"Algahtani H, Shirah B, Alqahtani AJ, Al-Malki AQ (2020) Irreversible cerebellar atrophy as a complication of short-term phenytoin exposure: clinical improvement following discontinuation of the culprit. J Epilepsy Res 10:96","journal-title":"J Epilepsy Res"},{"key":"5915_CR2","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1159\/000500314","volume":"104","author":"S Alqahtani","year":"2019","unstructured":"Alqahtani S, Alzaidi T, Alotaibi M, Alsultan A (2019) Estimation of phenytoin pharmacokinetic parameters in Saudi epileptic patients. Pharmacology 104:60\u201366","journal-title":"Pharmacology"},{"key":"5915_CR3","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1177\/2042098614551938","volume":"5","author":"SL Anderson","year":"2014","unstructured":"Anderson SL (2014) Dapagliflozin efficacy and safety: a perspective review. Ther Adv Drug Saf 5:242\u2013254","journal-title":"Ther Adv Drug Saf"},{"key":"5915_CR4","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1021\/acschemneuro.0c00722","volume":"12","author":"HH Arab","year":"2021","unstructured":"Arab HH, Safar MM, Shahin NN (2021) Targeting ROS-dependent AKT\/GSK-3\u03b2\/NF-\u03baB and DJ-1\/Nrf2 pathways by dapagliflozin attenuates neuronal injury and motor dysfunction in rotenone-induced Parkinson\u2019s disease rat model. ACS Chem Neurosci 12:689\u2013703","journal-title":"ACS Chem Neurosci"},{"key":"5915_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11113000","volume":"11","author":"HH Arab","year":"2023","unstructured":"Arab HH, Eid AH, Alsufyani SE, Ashour AM, El-Sheikh AA, Darwish HW, Sabry FM (2023) Targeting autophagy, apoptosis, and oxidative perturbations with dapagliflozin mitigates cadmium-induced cognitive dysfunction in rats. Biomedicines 11:3000","journal-title":"Biomedicines"},{"key":"5915_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-026-46231-4","volume":"16","author":"AH Attaai","year":"2026","unstructured":"Attaai AH, Noreldin AE, Nomir AG, Hussein MT (2026) Glial cell mapping in the camel cerebellar cortex: a histochemical and immunohistochemical study. Sci Rep 16:13404","journal-title":"Sci Rep"},{"key":"5915_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2020.105679","volume":"230","author":"S Bao","year":"2021","unstructured":"Bao S, He C, Ku P, Xie M, Lin J, Lu S, Nie X (2021) Effects of triclosan on the RedoximiRs\/Sirtuin\/Nrf2\/ARE signaling pathway in mosquitofish (Gambusia affinis). Aquat Toxicol 230:105679","journal-title":"Aquat Toxicol"},{"key":"5915_CR8","doi-asserted-by":"publisher","first-page":"2440","DOI":"10.1016\/j.cub.2014.08.056","volume":"24","author":"RA Barton","year":"2014","unstructured":"Barton RA, Venditti C (2014) Rapid evolution of the cerebellum in humans and other great apes. Curr Biol 24:2440\u20132444","journal-title":"Curr Biol"},{"key":"5915_CR9","first-page":"509","volume":"43","author":"EA Bekheet","year":"2020","unstructured":"Bekheet EA (2020) The possible protective role of selenium against long-term phenytoin administration effects on cerebellar cortex of adult male albino rats: histological and immunohistochemical study. Egypt J Histol 43:509\u2013518","journal-title":"Egypt J Histol"},{"key":"5915_CR10","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1080\/00207454.2022.2057849","volume":"133","author":"V Bhatt","year":"2023","unstructured":"Bhatt V, Tiwari AK (2023) Sirtuins, a key regulator of ageing and age-related neurodegenerative diseases. Int J Neurosci 133:1167\u20131192","journal-title":"Int J Neurosci"},{"key":"5915_CR11","doi-asserted-by":"publisher","first-page":"8.12. 1","DOI":"10.1002\/0471142301.ns0812s15","volume":"15","author":"RJ Carter","year":"2001","unstructured":"Carter RJ, Morton J, Dunnett SB (2001) Motor coordination and balance in rodents. Curr Protoc Neurosci 15:8.12. 1-8.12. 14","journal-title":"Curr Protoc Neurosci"},{"key":"5915_CR12","doi-asserted-by":"publisher","first-page":"277","DOI":"10.31083\/j.jin.2019.03.174","volume":"18","author":"J Chen","year":"2019","unstructured":"Chen J, Liu N, Wang X, Zhao Y, He J, Yang L, Sun Q, Zhao J, Wang L, Chen L (2019) Dl-3-n-butylphthalide inhibits phenytoin-induced neuronal apoptosis in rat hippocampus and cerebellum. J Integr Neurosci 18:277\u2013283","journal-title":"J Integr Neurosci"},{"key":"5915_CR13","doi-asserted-by":"publisher","first-page":"145","DOI":"10.4149\/gpb_2015034","volume":"35","author":"YH Choi","year":"2016","unstructured":"Choi YH (2016) The cytoprotective effect of isorhamnetin against oxidative stress is mediated by the upregulation of the Nrf2-dependent HO-1 expression in C2C12 myoblasts through scavenging reactive oxygen species and ERK inactivation. Gen Physiol Biophys 35:145\u2013154","journal-title":"Gen Physiol Biophys"},{"key":"5915_CR14","doi-asserted-by":"crossref","unstructured":"Dandekar A, Mendez R and Zhang K (2015) Cross talk between ER stress, oxidative stress, and inflammation in health and disease. Methods Mol Biol 1292:205\u201314","DOI":"10.1007\/978-1-4939-2522-3_15"},{"key":"5915_CR15","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s12883-018-1086-4","volume":"18","author":"MA Erdogan","year":"2018","unstructured":"Erdogan MA, Yusuf D, Christy J, Solmaz V, Erdogan A, Taskiran E, Erbas O (2018) Highly selective SGLT2 inhibitor dapagliflozin reduces seizure activity in pentylenetetrazol-induced murine model of epilepsy. BMC Neurol 18:81","journal-title":"BMC Neurol"},{"key":"5915_CR16","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1080\/14740338.2022.2058487","volume":"21","author":"R Ferner","year":"2022","unstructured":"Ferner R, Day R, Bradberry SM (2022) Phenytoin and damage to the cerebellum\u2013a systematic review of published cases. Expert Opin Drug Saf 21:957\u2013977","journal-title":"Expert Opin Drug Saf"},{"key":"5915_CR17","doi-asserted-by":"publisher","first-page":"15837","DOI":"10.1007\/s00210-025-04136-5","volume":"398","author":"NM Gamal","year":"2025","unstructured":"Gamal NM, Bakly WE, Saad SS, Waseef DaE, El-Shal AS, Ezzat W, Magdy YM (2025) Dapagliflozin mitigates cognitive deficits in a rat model of chronic restrained stress by addressing insulin resistance and mitochondrial dysfunction. Naunyn Schmiedebergs Arch Pharmacol 398:15837\u201315855","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"5915_CR18","doi-asserted-by":"publisher","DOI":"10.3791\/1787","author":"SJ Guyenet","year":"2010","unstructured":"Guyenet SJ, Furrer SA, Damian VM, Baughan TD, La Spada AR, Garden GA (2010) A simple composite phenotype scoring system for evaluating mouse models of cerebellar ataxia. J vis Exp. https:\/\/doi.org\/10.3791\/1787","journal-title":"J vis Exp"},{"key":"5915_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108503","volume":"104","author":"RM Hazem","year":"2022","unstructured":"Hazem RM, Ibrahim AZ, Ali DA, Moustafa YM (2022) Dapagliflozin improves steatohepatitis in diabetic rats via inhibition of oxidative stress and inflammation. Int Immunopharmacol 104:108503","journal-title":"Int Immunopharmacol"},{"key":"5915_CR20","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.cotox.2016.10.002","volume":"1","author":"KM Holmstr\u00f6m","year":"2016","unstructured":"Holmstr\u00f6m KM, Kostov RV, Dinkova-Kostova AT (2016) The multifaceted role of Nrf2 in mitochondrial function. Curr Opin Toxicol 1:80\u201391","journal-title":"Curr Opin Toxicol"},{"key":"5915_CR21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231710146","volume":"23","author":"P-L Hsieh","year":"2022","unstructured":"Hsieh P-L, Chu P-M, Cheng H-C, Huang Y-T, Chou W-C, Tsai K-L, Chan S-H (2022) Dapagliflozin mitigates doxorubicin-caused myocardium damage by regulating AKT-mediated oxidative stress, cardiac remodeling, and inflammation. Int J Mol Sci 23:10146","journal-title":"Int J Mol Sci"},{"key":"5915_CR22","doi-asserted-by":"crossref","unstructured":"Joshua AM (2022) Physiotherapy for adult neurological conditions. Springer","DOI":"10.1007\/978-981-19-0209-3"},{"key":"5915_CR23","unstructured":"Kiernan JA (2015) Histological and histochemical methods. 5th edn. chapter 6. Scion publishing ltd"},{"key":"5915_CR24","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1089\/ars.2013.5825","volume":"23","author":"W Kim","year":"2015","unstructured":"Kim W, Kim H-U, Lee H-N, Kim SH, Kim C, Cha Y-N, Joe Y, Chung HT, Jang J, Kim K (2015) Taurine chloramine stimulates efferocytosis through upregulation of Nrf2-mediated heme oxygenase-1 expression in murine macrophages: possible involvement of carbon monoxide. Antioxid Redox Signal 23:163\u2013177","journal-title":"Antioxid Redox Signal"},{"key":"5915_CR25","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1007\/s00424-020-02441-x","volume":"472","author":"H Koepsell","year":"2020","unstructured":"Koepsell H (2020) Glucose transporters in brain in health and disease. Pflugers Arch Eur J Physiol 472:1299\u20131343","journal-title":"Pflugers Arch Eur J Physiol"},{"key":"5915_CR26","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s12192-019-00977-1","volume":"24","author":"Q Liu","year":"2019","unstructured":"Liu Q, Jin Z, Xu Z, Yang H, Li L, Li G, Li F, Gu S, Zong S, Zhou J (2019) Antioxidant effects of ginkgolides and bilobalide against cerebral ischemia injury by activating the Akt\/Nrf2 pathway in vitro and in vivo. Cell Stress Chaperones 24:441\u2013452","journal-title":"Cell Stress Chaperones"},{"key":"5915_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114117","volume":"148","author":"Y Liu","year":"2025","unstructured":"Liu Y, Yu Y, Chen C, Wu X, Zheng Q, Zhang X, Ye L, Zhang C, Feng Z (2025) Dapagliflozin alleviated seizures and cognition impairment in pilocarpine induced status epilepticus via suppressing microglia-mediated neuroinflammation and oxidative stress. Int Immunopharmacol 148:114117","journal-title":"Int Immunopharmacol"},{"key":"5915_CR28","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.radcr.2023.10.064","volume":"19","author":"E Mogere","year":"2024","unstructured":"Mogere E, Cheruiyot D, Nassiuma M (2024) Phenytoin-induced cerebellar atrophy: a case for reversibility of neurological decline. Radiol Case Rep 19:442\u2013444","journal-title":"Radiol Case Rep"},{"key":"5915_CR29","doi-asserted-by":"publisher","first-page":"21","DOI":"10.14581\/jer.17004","volume":"7","author":"H-J Moon","year":"2017","unstructured":"Moon H-J, Jeon B (2017) Can therapeutic-range chronic phenytoin administration cause cerebellar ataxia? J Epilepsy Res 7:21","journal-title":"J Epilepsy Res"},{"key":"5915_CR30","doi-asserted-by":"crossref","first-page":"OC13","DOI":"10.1111\/crj.13556","volume":"17","author":"B More","year":"2023","unstructured":"More B, Murugesan S, Prakash TA (2023) Clinical profile of patients on antiepileptic drugs experiencing ataxia as an adverse drug reaction: a longitudinal observational study. J Clin Diagn Res 17:OC13\u2013OC16","journal-title":"J Clin Diagn Res"},{"key":"5915_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010265","volume":"21","author":"A Nagappan","year":"2019","unstructured":"Nagappan A, Kim J-H, Jung DY, Jung MH (2019) Cryptotanshinone from the Salvia miltiorrhiza bunge attenuates ethanol-induced liver injury by activation of AMPK\/SIRT1 and Nrf2 signaling pathways. Int J Mol Sci 21:265","journal-title":"Int J Mol Sci"},{"key":"5915_CR32","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1111\/ajt.14586","volume":"18","author":"K Nakamura","year":"2018","unstructured":"Nakamura K, Kageyama S, Yue S, Huang J, Fujii T, Ke B, Sosa RA, Reed EF, Datta N, Zarrinpar A (2018) Heme oxygenase-1 regulates sirtuin-1\u2013autophagy pathway in liver transplantation: From mouse to human. Am J Transplant 18:1110\u20131121","journal-title":"Am J Transplant"},{"key":"5915_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27217174","volume":"27","author":"MM Nakhal","year":"2022","unstructured":"Nakhal MM, Aburuz S, Sadek B, Akour A (2022) Repurposing SGLT2 inhibitors for neurological disorders: a focus on the autism spectrum disorder. Molecules 27:7174","journal-title":"Molecules"},{"key":"5915_CR34","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1021\/acs.jmedchem.5b01509","volume":"59","author":"A Nikam","year":"2016","unstructured":"Nikam A, Ollivier A, Rivard M, Wilson JL, Mebarki K, Martens T, Dubois-Rand\u00e9 J-L, Motterlini R, Foresti R (2016) Diverse Nrf2 activators coordinated to cobalt carbonyls induce heme oxygenase-1 and release carbon monoxide in vitro and in vivo. J Med Chem 59:756\u2013762","journal-title":"J Med Chem"},{"key":"5915_CR35","doi-asserted-by":"publisher","first-page":"A. 3A. 1","DOI":"10.1002\/0471141755.pha03as38","volume":"38","author":"BJ Olson","year":"2007","unstructured":"Olson BJ, Markwell J (2007) Assays for determination of protein concentration. Curr Protoc Pharmacol 38:A. 3A. 1-A. 3A. 29","journal-title":"Curr Protoc Pharmacol"},{"key":"5915_CR36","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1080\/20905068.2021.1948157","volume":"57","author":"OS Osuntokun","year":"2021","unstructured":"Osuntokun OS, Aderoju MO, Adebisi IE, Abayomi TA, Tokunbo OS, Olayiwola G (2021) Phenytoin\u2013levetiracetam adjunctive treatment-induced neurotoxicity and deregulation of cholinergic neurotransmission with evidence of neurocognitive impairment in male Wistar rats. Alexandria J Med 57:194\u2013204","journal-title":"Alexandria J Med"},{"key":"5915_CR37","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.2337\/dc21-0300","volume":"44","author":"F Persson","year":"2021","unstructured":"Persson F, Rossing P, Vart P, Chertow GM, Hou FF, Jongs N, Mcmurray JJ, Correa-Rotter R, Bajaj HS, Stefansson BV (2021) Efficacy and safety of dapagliflozin by baseline glycemic status: a prespecified analysis from the DAPA-CKD trial. Diabetes Care 44:1894\u20131897","journal-title":"Diabetes Care"},{"key":"5915_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2024.1289663","volume":"11","author":"V Quagliariello","year":"2024","unstructured":"Quagliariello V, Canale ML, Bisceglia I, Iovine M, Paccone A, Maurea C, Scherillo M, Merola A, Giordano V, Palma G (2024) Sodium-glucose cotransporter 2 inhibitor dapagliflozin prevents ejection fraction reduction, reduces myocardial and renal NF-\u03baB expression and systemic pro-inflammatory biomarkers in models of short-term doxorubicin cardiotoxicity. Front Cardiovasc Med 11:1289663","journal-title":"Front Cardiovasc Med"},{"key":"5915_CR39","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1177\/104063870802000401","volume":"20","author":"JA Ramos-Vara","year":"2008","unstructured":"Ramos-Vara JA, Kiupel M, Baszler T, Bliven L, Brodersen B, Chelack B, West K, Czub S, Del Piero F, Dial S (2008) Suggested guidelines for immunohistochemical techniques in veterinary diagnostic laboratories. J Vet Diagn Invest 20:393\u2013413","journal-title":"J Vet Diagn Invest"},{"key":"5915_CR40","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1097\/nen.0b013e31802d6da9","volume":"66","author":"CP Ramsey","year":"2007","unstructured":"Ramsey CP, Glass CA, Montgomery MB, Lindl KA, Ritson GP, Chia LA, Hamilton RL, Chu CT, Jordan-Sciutto KL (2007) Expression of Nrf2 in neurodegenerative diseases. J Neuropathol Exp Neurol 66:75\u201385","journal-title":"J Neuropathol Exp Neurol"},{"key":"5915_CR41","doi-asserted-by":"publisher","first-page":"409","DOI":"10.4103\/tcmj.tcmj_74_22","volume":"34","author":"JP Rissardo","year":"2022","unstructured":"Rissardo JP, Caprara ALF (2022) Phenytoin-associated movement disorder: a literature review. Tzu Chi Medical Journal 34:409\u2013417","journal-title":"Tzu Chi Medical Journal"},{"key":"5915_CR42","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25225474","volume":"25","author":"S Saha","year":"2020","unstructured":"Saha S, Buttari B, Panieri E, Profumo E, Saso L (2020) An overview of Nrf2 signaling pathway and its role in inflammation. Molecules 25:5474","journal-title":"Molecules"},{"key":"5915_CR43","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.045021","volume":"13","author":"M Salman","year":"2020","unstructured":"Salman M, Tabassum H, Parvez S (2020) Nrf2\/HO-1 mediates the neuroprotective effects of pramipexole by attenuating oxidative damage and mitochondrial perturbation after traumatic brain injury in rats. Dis Model Mech 13:dmm045021","journal-title":"Dis Model Mech"},{"key":"5915_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2025.102725","volume":"93","author":"MA Samak","year":"2025","unstructured":"Samak MA, Elfakharany YM, Huessiny N, Alsemeh AE (2025) Gold nanoparticles \u201cAuNPs\u201d-mediated amelioration of experimentally toxic-induced cerebellar syndrome: Insights into cytomolecular and immuno-histochemical modifications, with a focus on CREB\/Tau modulation. Tissue Cell 93:102725","journal-title":"Tissue Cell"},{"key":"5915_CR45","doi-asserted-by":"crossref","unstructured":"Saraswathy G, Maheswari E, Santhrani T (2015) Protective effect of alpha lipoic acid against phenytoin induced behavioral abnormalities in rats. J Mol Biomarker Diagnosis 5 241","DOI":"10.4172\/2155-9929.1000241"},{"key":"5915_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2024.115280","volume":"476","author":"P Sethi","year":"2025","unstructured":"Sethi P, Mehan S, Khan Z, Maurya PK, Kumar N, Kumar A, Tiwari A, Sharma T, Gupta GD, Narula AS (2025) The SIRT-1\/Nrf2\/HO-1 axis: guardians of neuronal health in neurological disorders. Behav Brain Res 476:115280","journal-title":"Behav Brain Res"},{"key":"5915_CR47","first-page":"1697","volume":"31","author":"AS Shaikh","year":"2018","unstructured":"Shaikh AS, Li Y, Cao L, Guo R (2018) Analysis of phenytoin drug concentration for evaluation of clinical response, uncontrolled seizures and toxicity. Pak J Pharm Sci 31:1697\u20131700","journal-title":"Pak J Pharm Sci"},{"key":"5915_CR48","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1093\/gerona\/glx177","volume":"73","author":"S Tarantini","year":"2018","unstructured":"Tarantini S, Valcarcel-Ares MN, Yabluchanskiy A, Tucsek Z, Hertelendy P, Kiss T, Gautam T, Zhang XA, Sonntag WE, De Cabo R (2018) Nrf2 deficiency exacerbates obesity-induced oxidative stress, neurovascular dysfunction, blood\u2013brain barrier disruption, neuroinflammation, amyloidogenic gene expression, and cognitive decline in mice, mimicking the aging phenotype. J Gerontol A Biol Sci Med Sci 73:853\u2013863","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"5915_CR49","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26188907","volume":"26","author":"H Tkaczenko","year":"2025","unstructured":"Tkaczenko H, Buyun L, Ko\u0142odziejska R, Kami\u0144ski P, Kurhaluk N (2025) Neuroactive phytochemicals as multi-target modulators of mental health and cognitive function: an integrative review. Int J Mol Sci 26:8907","journal-title":"Int J Mol Sci"},{"key":"5915_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.dscb.2021.100019","volume":"3","author":"S Upadhayay","year":"2021","unstructured":"Upadhayay S, Mehan S (2021) Targeting Nrf2\/HO-1 anti-oxidant signaling pathway in the progression of multiple sclerosis and influences on neurological dysfunctions. Brain Disorders 3:100019","journal-title":"Brain Disorders"},{"key":"5915_CR51","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1007\/s40263-014-0200-4","volume":"28","author":"B Van De Warrenburg","year":"2014","unstructured":"Van De Warrenburg B, H\u00e4rmark L, Maas R, Kerstens F, Van Gaalen J (2014) Drug-induced cerebellar ataxia: a systematic review. CNS Drugs 28:1139\u20131153","journal-title":"CNS Drugs"},{"key":"5915_CR52","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.phrs.2012.10.010","volume":"67","author":"J Xie","year":"2013","unstructured":"Xie J, Zhang X, Zhang L (2013) Negative regulation of inflammation by SIRT1. Pharmacol Res 67:60\u201367","journal-title":"Pharmacol Res"},{"key":"5915_CR53","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ijcard.2021.08.007","volume":"342","author":"J-J Xu","year":"2021","unstructured":"Xu J-J, Cui J, Lin Q, Chen X-Y, Zhang J, Gao E-H, Wei B, Zhao W (2021) Protection of the enhanced Nrf2 deacetylation and its downstream transcriptional activity by SIRT1 in myocardial ischemia\/reperfusion injury. Int J Cardiol 342:82\u201393","journal-title":"Int J Cardiol"},{"key":"5915_CR54","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/jcp.26851","volume":"234","author":"H Yaribeygi","year":"2019","unstructured":"Yaribeygi H, Butler AE, Atkin SL, Katsiki N, Sahebkar A (2019) Sodium\u2013glucose cotransporter 2 inhibitors and inflammation in chronic kidney disease: possible molecular pathways. J Cell Physiol 234:223\u2013230","journal-title":"J Cell Physiol"},{"key":"5915_CR55","doi-asserted-by":"publisher","first-page":"C240","DOI":"10.1152\/ajpcell.00317.2012","volume":"304","author":"AS Yu","year":"2013","unstructured":"Yu AS, Hirayama BA, Timbol G, Liu J, Diez-Sampedro A, Kepe V, Satyamurthy N, Huang S-C, Wright EM, Barrio JR (2013) Regional distribution of SGLT activity in rat brain in vivo. Am J Physiol Cell Physiol 304:C240\u2013C247","journal-title":"Am J Physiol Cell Physiol"},{"key":"5915_CR56","first-page":"2334","volume":"12","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Yin N, Liang S, Shen S, Li D, Faiola F (2019) 5-fluorouracil-induced neurotoxicity in rat cerebellum granule cells involves oxidative stress and activation of caspase-3 pathway. Int J Clin Exp Med 12:2334\u20132343","journal-title":"Int J Clin Exp Med"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05915-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05915-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05915-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:09:31Z","timestamp":1790611771000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05915-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":56,"alternative-id":["5915"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05915-4","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]},"assertion":[{"value":"16 August 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was authorized by The Institutional of Animal Care and Use Committee (IACUC), approval number; MUFMED\/F\/Ph\/26 at Faculty of Science, Menoufia University, Egypt. All methods were conducted in agreement with the Guide for the Care and Use of Laboratory Animals (Vol. 1, 2nd ed., 1993, and Vol. 2, 1984, Canadian Council on Animal Care).","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}