{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:45:35Z","timestamp":1792079135153,"version":"4.4.0"},"reference-count":423,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"DOI":"10.1007\/s00210-026-05940-3","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:16:53Z","timestamp":1792066613000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nanocarriers in psychiatry: a comprehensive review of emerging frontiers in the management of psychiatric disorders"],"prefix":"10.1007","author":[{"given":"Rodayna Atef","family":"Shalaby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omaima Naim","family":"El Gazayerly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Abdallah","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Magdy","family":"Farag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevine Shawky","family":"AbdelMalak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"issue":"1\u20132","key":"5940_CR1","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/J.IJPHARM.2013.04.084","volume":"452","author":"GA Abdelbary","year":"2013","unstructured":"Abdelbary GA, Tadros MI (2013) Brain targeting of olanzapine via intranasal delivery of core\u2013shell difunctional block copolymer mixed nanomicellar carriers: in vitro characterization, ex vivo estimation of nasal toxicity and in vivo biodistribution studies. Int J Pharm 452(1\u20132):300\u2013310. https:\/\/doi.org\/10.1016\/J.IJPHARM.2013.04.084","journal-title":"Int J Pharm"},{"key":"5940_CR2","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/J.MATPR.2021.08.218","volume":"61","author":"HA Abdul Hussein","year":"2022","unstructured":"Abdul Hussein HA, Maraie NK (2022) Tenoxicam-loaded polymeric micelles material: formulation, optimization, and evaluation. Mater Today Proc 61:672\u2013680. https:\/\/doi.org\/10.1016\/J.MATPR.2021.08.218","journal-title":"Mater Today Proc"},{"key":"5940_CR3","doi-asserted-by":"publisher","unstructured":"Abdullah S, Alhakamy NA, AlKhatib HS, Huwaij RA, Alahdal H, Altamimi AA (2024a) Casein and acryl amide complexation and bio-adhesive polymeric nano micelles influence on vortioxetine dissolution, penetration enhancement and in vivo absorption. Food Hydrocoll Health 6. https:\/\/doi.org\/10.1016\/J.FHFH.2024.100189","DOI":"10.1016\/J.FHFH.2024.100189"},{"key":"5940_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2023.173661","author":"HM Abelaira","year":"2023","unstructured":"Abelaira HM, de Moura AB, Cardoso MM, de Pieri E, Abel JS, Luiz GP, Sombrio EM, Borghezan LA, Anast\u00e1cio RS, Cruz LA, de Souza TG, Meab C, Lima IR, da Costa C, Dal B\u00f3 AG, Pcl S, Machado-de-\u00c1vila RA (2023) Sertraline associated with gold nanoparticles reduce cellular toxicity and induce sex-specific responses in behavior and neuroinflammation biomarkers in a mouse model of anxiety. Pharmacol Biochem Behav. https:\/\/doi.org\/10.1016\/j.pbb.2023.173661","journal-title":"Pharmacol Biochem Behav"},{"issue":"2","key":"5940_CR5","doi-asserted-by":"publisher","first-page":"249","DOI":"10.3390\/PH15020249\/S1","volume":"15","author":"HA Abo El-Enin","year":"2022","unstructured":"Abo El-Enin HA, Ahmed MF, Naguib IA, El-Far SW, Ghoneim MM, Alsalahat I, Abdel-Bar HM (2022) Utilization of polymeric micelles as a lucrative platform for efficient brain deposition of olanzapine as an antischizophrenic drug via intranasal delivery. Pharmaceuticals 15(2):249. https:\/\/doi.org\/10.3390\/PH15020249\/S1","journal-title":"Pharmaceuticals"},{"key":"5940_CR6","doi-asserted-by":"publisher","unstructured":"Abo El-Enin HA, Tulbah AS, Darwish HW, Salama R, Naguib IA, Yassin HA, Abdel-Bar HM (2023) Evaluation of brain targeting and antipsychotic activity of nasally administrated ziprasidone lipid\u2013polymer hybrid nanocarriers. Pharmaceuticals (Basel) 16(6):886.\u00a0https:\/\/doi.org\/10.3390\/ph16060886","DOI":"10.3390\/ph16060886"},{"issue":"15","key":"5940_CR7","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1039\/d2tb00031h","volume":"10","author":"MAS Abourehab","year":"2022","unstructured":"Abourehab MAS, Ansari MJ, Singh A, Hassan A, Abdelgawad MA, Shrivastav P, Abualsoud BM, Amaral LS, Pramanik S (2022) Cubosomes as an emerging platform for drug delivery: a review of the state of the art. J Mater Chem B 10(15):2781\u20132819. https:\/\/doi.org\/10.1039\/d2tb00031h","journal-title":"J Mater Chem B"},{"key":"5940_CR8","doi-asserted-by":"publisher","DOI":"10.1136\/BMJ-2024-083443","author":"JS Abramowitz","year":"2026","unstructured":"Abramowitz JS, Abramovitch A, McKay D, Draffin A (2026) Management of obsessive-compulsive disorder in adults. BMJ. https:\/\/doi.org\/10.1136\/BMJ-2024-083443","journal-title":"BMJ"},{"issue":"1","key":"5940_CR9","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-06043-6","volume":"7","author":"A Abrishami","year":"2024","unstructured":"Abrishami A, Bahrami AR, Nekooei S, Sh. Saljooghi A, Matin MM (2024) Hybridized quantum dot, silica, and gold nanoparticles for targeted chemo-radiotherapy in colorectal cancer theranostics. Commun Biol 7(1). https:\/\/doi.org\/10.1038\/s42003-024-06043-6","journal-title":"Commun Biol"},{"key":"5940_CR10","doi-asserted-by":"publisher","unstructured":"Adwan S, Obeidi T, Al-Akayleh F (2024) Chitosan nanoparticles embedded in in situ gel for nasal delivery of imipramine hydrochloride: short-term stage development and controlled release evaluation. Polymers (Basel) 16(21):3062.\u00a0https:\/\/doi.org\/10.3390\/polym16213062","DOI":"10.3390\/polym16213062"},{"issue":"2","key":"5940_CR11","doi-asserted-by":"publisher","first-page":"184","DOI":"10.2174\/1567201817999200728135119","volume":"18","author":"S Agarwal","year":"2021","unstructured":"Agarwal S, HariKumar SL, Negi P, Upadhyay N, Garg R (2021) Quetiapine fumarate loaded nanostructured lipid carrier for enhancing oral bioavailability: design, development and pharmacokinetic assessment. Curr Drug Deliv 18(2):184\u2013198. https:\/\/doi.org\/10.2174\/1567201817999200728135119","journal-title":"Curr Drug Deliv"},{"issue":"1","key":"5940_CR12","doi-asserted-by":"publisher","first-page":"27","DOI":"10.2174\/2468187313666230320115153\/CITE\/REFWORKS","volume":"13","author":"R Agrawal","year":"2023","unstructured":"Agrawal R, Chauhan CS, Garg A (2023) A snapshot on polymeric micelles as a carrier for drug delivery. Current Nanomedicine 13(1):27\u201338. https:\/\/doi.org\/10.2174\/2468187313666230320115153\/CITE\/REFWORKS","journal-title":"Current Nanomedicine"},{"issue":"1","key":"5940_CR13","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3390\/PHARMACEUTICS17010036","volume":"17","author":"SS Agrawal","year":"2024","unstructured":"Agrawal SS, Baliga V, Londhe VY (2024) Liposomal formulations: a recent update. Pharm 17(1):36. https:\/\/doi.org\/10.3390\/PHARMACEUTICS17010036","journal-title":"Pharm"},{"key":"5940_CR14","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1016\/j.ijbiomac.2020.11.107","volume":"167","author":"MM Agwa","year":"2021","unstructured":"Agwa MM, Sabra S (2021) Lactoferrin coated or conjugated nanomaterials as an active targeting approach in nanomedicine. Int J Biol Macromol 167:1527\u20131543. https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.11.107","journal-title":"Int J Biol Macromol"},{"issue":"7","key":"5940_CR15","doi-asserted-by":"publisher","first-page":"8093","DOI":"10.1007\/S00289-022-04436-3","volume":"80","author":"N Ahmad","year":"2023","unstructured":"Ahmad N, Khalid MS, Al Ramadhan AM, Alaradi MZ, Al Hammad MR, Ansari K, Alqurashi YD, Khan MF, Albassam AA, Ansari MJ, Akhtar S, Dilshad M (2023) Preparation of melatonin novel-mucoadhesive nanoemulsion used in the treatment of depression. Polym Bull 80(7):8093\u20138132. https:\/\/doi.org\/10.1007\/S00289-022-04436-3","journal-title":"Polym Bull"},{"issue":"33","key":"5940_CR16","doi-asserted-by":"publisher","first-page":"23952","DOI":"10.1039\/D4RA04624B","volume":"14","author":"N Ahmad","year":"2024","unstructured":"Ahmad N, Ansari K, Alamoudi MK, Haque A, Ullah Z, Khalid MS, Ahmad S (2024) A novel mucoadhesive paliperidone-nanoemulsion developed using the ultrasonication method in the treatment of schizophrenia. RSC Adv 14(33):23952. https:\/\/doi.org\/10.1039\/D4RA04624B","journal-title":"RSC Adv"},{"key":"5940_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJPHARM.2022.122099","volume":"625","author":"F Ahmadi","year":"2022","unstructured":"Ahmadi F, Sodagar-Taleghani A, Ebrahimnejad P, Pouya Hadipour Moghaddam S, Ebrahimnejad F, Asare-Addo K, Nokhodchi A (2022) A review on the latest developments of mesoporous silica nanoparticles as a promising platform for diagnosis and treatment of cancer. Int J Pharm 625. https:\/\/doi.org\/10.1016\/J.IJPHARM.2022.122099","journal-title":"Int J Pharm"},{"issue":"1","key":"5940_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/17425247.2020.1822321","volume":"18","author":"A Ahmed","year":"2021","unstructured":"Ahmed A, Sarwar S, Hu Y, Munir MU, Nisar MF, Ikram F, Asif A, Rahman SU, Chaudhry AA, Rehman IU (2021) Surface-modified polymeric nanoparticles for drug delivery to cancer cells. Expert Opin Drug Deliv 18(1):1\u201324. https:\/\/doi.org\/10.1080\/17425247.2020.1822321","journal-title":"Expert Opin Drug Deliv"},{"key":"5940_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2024.113926","author":"S Akar","year":"2024","unstructured":"Akar S, Fardindoost S, Hoorfar M (2024) High throughput microfluidics-based synthesis of PEGylated liposomes for precise size control and efficient drug encapsulation. Colloids Surf B Biointerfaces. https:\/\/doi.org\/10.1016\/j.colsurfb.2024.113926","journal-title":"Colloids Surf B Biointerfaces"},{"key":"5940_CR20","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/J.COLSURFB.2016.05.091","volume":"145","author":"SP Akhlaghi","year":"2016","unstructured":"Akhlaghi SP, Ribeiro IR, Boyd BJ, Loh W (2016) Impact of preparation method and variables on the internal structure, morphology, and presence of liposomes in phytantriol-Pluronic\u00ae F127 cubosomes. Colloids Surf, B 145:845\u2013853. https:\/\/doi.org\/10.1016\/J.COLSURFB.2016.05.091","journal-title":"Colloids Surf, B"},{"issue":"2","key":"5940_CR21","doi-asserted-by":"publisher","first-page":"179","DOI":"10.2174\/1872210517666230120142439","volume":"18","author":"HM Alatawi","year":"2023","unstructured":"Alatawi HM, Alhwiti SS, Alsharif KA, Albalawi SS, Abusaleh SM, Sror GK, Qushawy M (2023) Nanostructured lipid carriers (NLCs) as effective drug delivery systems: methods of preparation and their therapeutic applications. Recent Pat Nanotechnol 18(2):179\u2013189. https:\/\/doi.org\/10.2174\/1872210517666230120142439","journal-title":"Recent Pat Nanotechnol"},{"issue":"8","key":"5940_CR22","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1080\/03639045.2021.1989454","volume":"47","author":"S Alavi","year":"2021","unstructured":"Alavi S, Mahjoob MA, Haeri A, Shirazi FH, Abbasian Z, Dadashzadeh S (2021) Multivesicular liposomal depot system for sustained delivery of risperidone: development, characterization, and toxicity assessment. Drug Dev Ind Pharm 47(8):1290\u20131301. https:\/\/doi.org\/10.1080\/03639045.2021.1989454","journal-title":"Drug Dev Ind Pharm"},{"key":"5940_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/J.JDDST.2022.103326","volume":"71","author":"ASM Alenazi","year":"2022","unstructured":"Alenazi ASM, El-Bagory IM, Yassin AB, Alanazi FK, Alsarra IA, Haq N, Bayomi MA, Shakeel F (2022) Design of polymeric nanoparticles for oral delivery of capreomycin peptide using double emulsion technique: impact of stress conditions. J Drug Deliv Sci Technol 71. https:\/\/doi.org\/10.1016\/J.JDDST.2022.103326","journal-title":"J Drug Deliv Sci Technol"},{"issue":"2","key":"5940_CR24","doi-asserted-by":"publisher","first-page":"145","DOI":"10.2217\/NNM-2022-0108","volume":"18","author":"FS Alhodieb","year":"2023","unstructured":"Alhodieb FS, Rahman MA, Barkat MA, Alanezi AA, Barkat HA, Hadi HA, Harwansh RK, Mittal V (2023) Nanomedicine-driven therapeutic interventions of autophagy and stem cells in the management of Alzheimer\u2019s disease. Nanomedicine 18(2):145\u2013168. https:\/\/doi.org\/10.2217\/NNM-2022-0108","journal-title":"Nanomedicine"},{"key":"5940_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/J.JDDST.2024.106417","volume":"102","author":"A Alhowyan","year":"2024","unstructured":"Alhowyan A, Imran M, Haque A, Kalam MA (2024) Surface-engineered niosomes of esculin hydrate for the management of depression via intranasal route: optimization, in vitro, ex vivo and pharmacokinetic assessment. J Drug Deliv Sci Technol 102. https:\/\/doi.org\/10.1016\/J.JDDST.2024.106417","journal-title":"J Drug Deliv Sci Technol"},{"issue":"3","key":"5940_CR26","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1176\/APPI.FOCUS.20230043","volume":"22","author":"Z Ali","year":"2024","unstructured":"Ali Z, Couturier J (2024) Psychopharmacology review for eating disorders among children, adolescents, and adults. Focus 22(3):307. https:\/\/doi.org\/10.1176\/APPI.FOCUS.20230043","journal-title":"Focus"},{"issue":"9","key":"5940_CR27","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.3390\/PHARMACEUTICS16091232","volume":"16","author":"A Almatroudi","year":"2024","unstructured":"Almatroudi A (2024) Unlocking the potential of silver nanoparticles: from synthesis to versatile bio-applications. Pharm 16(9):1232. https:\/\/doi.org\/10.3390\/PHARMACEUTICS16091232","journal-title":"Pharm"},{"key":"5940_CR28","doi-asserted-by":"publisher","unstructured":"AlMulhim FM, Nair AB, Aldhubiab B, Shah H, Shah J, Mewada V, Sreeharsha N, Jacob S (2023) Design, development, evaluation, and in vivo performance of buccal films embedded with paliperidone-loaded nanostructured lipid carrier. Pharmaceutics 15(11):2530.\u00a0https:\/\/doi.org\/10.3390\/pharmaceutics15112530","DOI":"10.3390\/pharmaceutics15112530"},{"issue":"1","key":"5940_CR29","doi-asserted-by":"publisher","DOI":"10.1186\/S12888-026-08017-W","volume":"26","author":"BF Alqurashi","year":"2026","unstructured":"Alqurashi BF, Alserihi AR, Albariqi A, Alenazi AA, Alhindi Y, Alghamdi RL, Alotaibi BA, Abanmi SN, Alhejaili FA, Nahhas FH (2026) Olanzapine effectiveness on weight gain in anorexia nervosa patients: systematic review and meta-analysis. BMC Psychiatry 26(1). https:\/\/doi.org\/10.1186\/S12888-026-08017-W","journal-title":"BMC Psychiatry"},{"key":"5940_CR30","doi-asserted-by":"publisher","first-page":"9823","DOI":"10.2147\/IJN.S279094","volume":"15","author":"SJ Amina","year":"2020","unstructured":"Amina SJ, Guo B (2020) A review on the synthesis and functionalization of gold nanoparticles as a drug delivery vehicle. Int J Nanomedicine 15:9823\u20139857. https:\/\/doi.org\/10.2147\/IJN.S279094","journal-title":"Int J Nanomedicine"},{"key":"5940_CR31","doi-asserted-by":"publisher","unstructured":"Arafa MG, Ghalwash D, El-Kersh DM, Elmazar MM (2018) Propolis-based niosomes as oromuco-adhesive films: a randomized clinical trial of a therapeutic drug delivery platform for the treatment of oral recurrent aphthous ulcers. Sci Rep 8(1): 18056-. https:\/\/doi.org\/10.1038\/S41598-018-37157-7;TECHMETA","DOI":"10.1038\/S41598-018-37157-7;TECHMETA"},{"key":"5940_CR32","doi-asserted-by":"publisher","unstructured":"Arif ST, Khan MA, Zaman S, uz Sarwar HS, Raza A, Sarfraz M, Bin Jardan YA, Amin MU, Sohail MF (2023) Enhanced antidepressant activity of nanostructured lipid carriers containing levosulpiride in behavioral despair tests in mice. Pharmaceuticals 16(9):1220. https:\/\/doi.org\/10.3390\/PH16091220","DOI":"10.3390\/PH16091220"},{"key":"5940_CR33","doi-asserted-by":"publisher","DOI":"10.1002\/ARDP.202300618","author":"VR Ayoub","year":"2024","unstructured":"Ayoub VR, Abdel-Mottaleb MMA, Ibrahem IT, Motaleb MA, Geneidi AS (2024) Novel radioiodinated desvenlafaxine\u2010loaded lipid nanocapsule for brain delivery. Arch Pharm (Weinheim). https:\/\/doi.org\/10.1002\/ARDP.202300618","journal-title":"Arch Pharm (Weinheim)"},{"key":"5940_CR34","doi-asserted-by":"publisher","unstructured":"Bahadur S, Pathak K (2012) Buffered nanoemulsion for nose to brain delivery of ziprasidone hydrochloride: preformulation and pharmacodynamic evaluation. Curr Drug Deliv 9(6):596\u2013607.\u00a0https:\/\/doi.org\/10.2174\/156720112803529792","DOI":"10.2174\/156720112803529792"},{"issue":"5","key":"5940_CR35","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1111\/ADD.15695","volume":"117","author":"DS Baldwin","year":"2022","unstructured":"Baldwin DS, Baldwin S (2022) Clinical management of withdrawal from benzodiazepine anxiolytic and hypnotic medications. Addiction 117(5):1472\u20131482. https:\/\/doi.org\/10.1111\/ADD.15695","journal-title":"Addiction"},{"key":"5940_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/J.PNPBP.2025.111393","volume":"139","author":"N Balic","year":"2025","unstructured":"Balic N, Nikolac Perkovic M, Milos T, Vuic B, Kurtovic Kodzoman M, Svob Strac D, Nedic Erjavec G (2025) Extracellular vesicles as a promising tool in neuropsychiatric pharmacotherapy application and monitoring. Prog Neuropsychopharmacol Biol Psychiatry 139. https:\/\/doi.org\/10.1016\/J.PNPBP.2025.111393","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"5940_CR37","doi-asserted-by":"publisher","DOI":"10.2174\/011570159X476596260714092620","author":"MA Barbieri","year":"2026","unstructured":"Barbieri MA, Bruzzone E, Spina E, Nicoletti F, de Filippis S, Fagiolini A (2026) Lithium formulations in clinical practice. Curr Neuropharmacol. https:\/\/doi.org\/10.2174\/011570159X476596260714092620","journal-title":"Curr Neuropharmacol"},{"key":"5940_CR38","doi-asserted-by":"publisher","unstructured":"Bari NK, Fazil M, Hassan MQ, Haider MR, Gaba B, Narang JK, Baboota S, Ali J (2015) Brain delivery of buspirone hydrochloride chitosan nanoparticles for the treatment of general anxiety disorder. Int J Biol Macromol 81:49\u201359.\u00a0https:\/\/doi.org\/10.1016\/j.ijbiomac.2015.07.041","DOI":"10.1016\/j.ijbiomac.2015.07.041"},{"issue":"9","key":"5940_CR39","doi-asserted-by":"publisher","first-page":"5505","DOI":"10.1021\/ACS.CHEMREV.3C00705","volume":"124","author":"MA Beach","year":"2024","unstructured":"Beach MA, Nayanathara U, Gao Y, Zhang C, Xiong Y, Wang Y, Such GK (2024) Polymeric nanoparticles for drug delivery. Chem Rev 124(9):5505\u20135616. https:\/\/doi.org\/10.1021\/ACS.CHEMREV.3C00705","journal-title":"Chem Rev"},{"key":"5940_CR40","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013613.PUB2","author":"F Bertolini","year":"2024","unstructured":"Bertolini F, Robertson L, Bisson JI, Meader N, Churchill R, Ostuzzi G, Stein DJ, Williams T, Barbui C (2024) Early pharmacological interventions for prevention of post-traumatic stress disorder (PTSD) in individuals experiencing acute traumatic stress symptoms. Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.CD013613.PUB2","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"5940_CR41","doi-asserted-by":"publisher","first-page":"512","DOI":"10.2174\/0122117385333634240911075833","volume":"13","author":"UK Biswas","year":"2025","unstructured":"Biswas UK, Bose A, Parmanik A (2025) Recent advances in the preparation, properties, and applications of solid lipid nanoparticles in drug delivery. Pharmaceutical Nanotechnology 13(3):512\u2013527. https:\/\/doi.org\/10.2174\/0122117385333634240911075833","journal-title":"Pharmaceutical Nanotechnology"},{"issue":"3","key":"5940_CR42","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1208\/S12249-016-0552-9","volume":"18","author":"M Boche","year":"2017","unstructured":"Boche M, Pokharkar V (2017) Quetiapine nanoemulsion for intranasal drug delivery: evaluation of brain-targeting efficiency. AAPS PharmSciTech 18(3):696\u2013686. https:\/\/doi.org\/10.1208\/S12249-016-0552-9","journal-title":"AAPS PharmSciTech"},{"issue":"6","key":"5940_CR43","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1134\/S0965545X1606002X","volume":"58","author":"S Bohrey","year":"2016","unstructured":"Bohrey S, Chourasiya V, Pandey A (2016) Preparation, optimization by 23 factorial design, characterization and in vitro release kinetics of lorazepam loaded PLGA nanoparticles. Polymer Sci Ser A 58(6):975\u2013986. https:\/\/doi.org\/10.1134\/S0965545X1606002X","journal-title":"Polymer Sci Ser A"},{"key":"5940_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/NANO11030749","author":"B Boltnarova","year":"2021","unstructured":"Boltnarova B, Kubackova J, Skoda J, Stefela A, Smekalova M, Svacinova P, Pavkova I, Dittrich M, Scherman D, Zbytovska J, Pavek P, Holas O (2021) PLGA based nanospheres as a potent macrophage-specific drug delivery system. Nanomaterials (Basel, Switzerland). https:\/\/doi.org\/10.3390\/NANO11030749","journal-title":"Nanomaterials (Basel, Switzerland)"},{"issue":"5","key":"5940_CR45","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1111\/ACEM.14911;WGROUP:STRING:PUBLICATION","volume":"31","author":"B Borgundvaag","year":"2024","unstructured":"Borgundvaag B, Bellolio F, Miles I, Schwarz ES, Sharif S, Su MK, Baumgartner K, Liss DB, Sheikh H, Vogel J, Austin EB, Upadhye S, Klaiman M, Vellend R, Munkley A, Carpenter CR (2024) Guidelines for Reasonable and Appropriate Care in the Emergency Department (GRACE-4): alcohol use disorder and cannabinoid hyperemesis syndrome management in the emergency department. Acad Emerg Med 31(5):425\u2013455. https:\/\/doi.org\/10.1111\/ACEM.14911;WGROUP:STRING:PUBLICATION","journal-title":"Acad Emerg Med"},{"key":"5940_CR46","doi-asserted-by":"publisher","unstructured":"Boukholda K, Aouey B, Guerrero-Hue M, Elbayoumi E, Boukholda F, Chtourou Y, Fiebich BL, Moreno JA, Fetoui H (2025) Purinergic system dysregulation and depression: the neuroinflammatory impact of silica nanoparticles. Environ Anal Health Toxicol 40(4). https:\/\/doi.org\/10.5620\/EAHT.2025030","DOI":"10.5620\/EAHT.2025030"},{"key":"5940_CR47","doi-asserted-by":"publisher","unstructured":"Boyuklieva R, Zahariev N, Simeonov P, Penkov D, Katsarov P (2025)\u200f Next-generation drug delivery for neurotherapeutics: the promise of stimuli-triggered nanocarriers\u200f. Biomedicines 13(6):1464. https:\/\/doi.org\/10.3390\/biomedicines13061464","DOI":"10.3390\/biomedicines13061464"},{"key":"5940_CR48","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/J.JCIS.2021.05.072","volume":"601","author":"SJ Bryant","year":"2021","unstructured":"Bryant SJ, Bathke EK, Edler KJ (2021) Bottom-up cubosome synthesis without organic solvents. J Colloid Interface Sci 601:98\u2013105. https:\/\/doi.org\/10.1016\/J.JCIS.2021.05.072","journal-title":"J Colloid Interface Sci"},{"issue":"6","key":"5940_CR49","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/S42452-024-05897-Z","volume":"6","author":"SPN Bukke","year":"2024","unstructured":"Bukke SPN, Venkatesh C, Bandenahalli Rajanna S, Saraswathi TS, Kusuma PK, Goruntla N, Balasuramanyam N, Munishamireddy S (2024) Solid lipid nanocarriers for drug delivery: design innovations and characterization strategies\u2014a comprehensive review. Discov Appl Sci 6(6):279. https:\/\/doi.org\/10.1007\/S42452-024-05897-Z","journal-title":"Discov Appl Sci"},{"key":"5940_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJPHARM.2024.124460","volume":"662","author":"G Buttitta","year":"2024","unstructured":"Buttitta G, Bonacorsi S, Barbarito C, Moliterno M, Pompei S, Saito G, Oddone I, Verdone G, Secci D, Raimondi S (2024) Scalable microfluidic method for tunable liposomal production by a design of experiment approach. Int J Pharm 662. https:\/\/doi.org\/10.1016\/J.IJPHARM.2024.124460","journal-title":"Int J Pharm"},{"issue":"1","key":"5940_CR51","doi-asserted-by":"publisher","first-page":"9933465","DOI":"10.1155\/2024\/9933465","volume":"2024","author":"N Cakir","year":"2024","unstructured":"Cakir N, Ozturk N, Kara A, Zarrabi A, Mustafaoglu N (2024) Optimizing niosomal formulations for enhanced cellular applications. Advances in Pharmacological and Pharmaceutical Sciences 2024(1):9933465. https:\/\/doi.org\/10.1155\/2024\/9933465","journal-title":"Advances in Pharmacological and Pharmaceutical Sciences"},{"key":"5940_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJPHARM.2024.124163","author":"C Camacho Vieira","year":"2024","unstructured":"Camacho Vieira C, Peltonen L, Karttunen AP, Ribeiro AJ (2024) Is it advantageous to use Quality by Design (QbD) to develop nanoparticle-based dosage forms for parenteral drug administration? Int J Pharm. https:\/\/doi.org\/10.1016\/J.IJPHARM.2024.124163","journal-title":"Int J Pharm"},{"key":"5940_CR53","doi-asserted-by":"publisher","unstructured":"Canchola A, Li K, Chen K, Borboa-Pimentel A, Chou C, Dela Rama R, Chen CY, Chen X, Strobel M, Riviere JE, Monteiro-Riviere NA, Wang M, Zhang F, Lin Z, Chou WC (2025)\u200f Meta-analysis and machine learning prediction of protein corona composition across nanoparticle systems in biological media\u200f. ACS Nano 19(43):37633\u201337650. https:\/\/doi.org\/10.1021\/acsnano.5c08608","DOI":"10.1021\/acsnano.5c08608"},{"issue":"9","key":"5940_CR54","doi-asserted-by":"publisher","first-page":"2578","DOI":"10.1007\/S13346-024-01646-2","volume":"14","author":"F Caputo","year":"2024","unstructured":"Caputo F, Favre G, Borchard G, Calzolai L, Fisicaro P, Frejafon E, G\u00fcnday-T\u00fcreli N, Koltsov D, Minelli C, Nelson BC, Parot J, Prina-Mello A, Zou S, Ouf FX (2024) Toward an international standardisation roadmap for nanomedicine. Drug Deliv Transl Res 14(9):2578\u20132588. https:\/\/doi.org\/10.1007\/S13346-024-01646-2","journal-title":"Drug Deliv Transl Res"},{"key":"5940_CR55","doi-asserted-by":"publisher","unstructured":"Carre\u00f1o F, Helfer VE, Staudt K, Staudt KJ, Paese K, Meyer FS, Herrmann AP, Guterres SS, Rates SMK, Costa TD (2020\u200f) Quetiapine lipid core nanocapsules restore prepulse inhibition deficits in a neurodevelopmental model of schizophrenia in male and female rats\u200f. Schizophr Res 218:173\u2013179. https:\/\/doi.org\/10.1016\/j.schres.2020.01.007","DOI":"10.1016\/j.schres.2020.01.007"},{"issue":"1","key":"5940_CR56","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1080\/09540261.2022.2040450","volume":"34","author":"JM Castaldelli-Maia","year":"2022","unstructured":"Castaldelli-Maia JM, Bhugra D (2022) Analysis of global prevalence of mental and substance use disorders within countries: focus on sociodemographic characteristics and income levels. Int Rev Psychiatry 34(1):6\u201315. https:\/\/doi.org\/10.1080\/09540261.2022.2040450","journal-title":"Int Rev Psychiatry"},{"issue":"6-7","key":"5940_CR57","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1080\/09540261.2025.2573752","volume":"37","author":"JM Castaldelli-Maia","year":"2025","unstructured":"Castaldelli-Maia JM, Ventriglio A, Torales J (2025) The global prevalence of mental disorders among adolescents: focus on sex, regional and socio-demographic differences. Int Rev Psychiatry 37(6-7):570\u2013580. https:\/\/doi.org\/10.1080\/09540261.2025.2573752","journal-title":"Int Rev Psychiatry"},{"key":"5940_CR58","doi-asserted-by":"publisher","unstructured":"Cayero-Otero MD, Gomes MJ, Martins C, \u00c1lvarez-Fuentes J, Fern\u00e1ndez-Ar\u00e9valo M, Sarmento B, Mart\u00edn-Banderas L (2019) In vivo biodistribution of venlafaxine-PLGA nanoparticles for brain delivery: plain vs. functionalized nanoparticles\u200f. Expert Opin Drug Deliv 16(12):1416-1413. https:\/\/doi.org\/10.1080\/17425247.2019.1690452","DOI":"10.1080\/17425247.2019.1690452"},{"key":"5940_CR59","doi-asserted-by":"publisher","unstructured":"Chan ACY (2026) Safety concerns, mechanistic pathways, and knowledge gaps in the clinical use of selective serotonin reuptake inhibitors. Cureus 18(1). https:\/\/doi.org\/10.7759\/CUREUS.100719","DOI":"10.7759\/CUREUS.100719"},{"issue":"26","key":"5940_CR60","doi-asserted-by":"publisher","first-page":"8919","DOI":"10.1523\/JNEUROSCI.0048-12.2012","volume":"32","author":"JC Chang","year":"2012","unstructured":"Chang JC, Tomlinson ID, Warnement MR, Ustione A, Carneiro AMD, Piston DW, Blakely RD, Rosenthal SJ (2012) Single molecule analysis of serotonin transporter regulation using antagonist-conjugated quantum dots reveals restricted, p38 MAPK-dependent mobilization underlying uptake activation. J Neurosci 32(26):8919\u20138929. https:\/\/doi.org\/10.1523\/JNEUROSCI.0048-12.2012","journal-title":"J Neurosci"},{"issue":"3","key":"5940_CR61","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3390\/PHARMACEUTICS17030337","volume":"17","author":"MD Chatzidaki","year":"2025","unstructured":"Chatzidaki MD, Mitsou E (2025) Advancements in nanoemulsion-based drug delivery across different administration routes. Pharm (Basel) 17(3):337. https:\/\/doi.org\/10.3390\/PHARMACEUTICS17030337","journal-title":"Pharm (Basel)"},{"key":"5940_CR62","doi-asserted-by":"publisher","unstructured":"Chen LF, Chen Y, Duan YY, Zhang MM, Xu PY, Kankala RK, Wang SB, Chen AZ (2022) Preparation of aripiprazole-poly(methyl vinyl ether- co-maleic anhydride) nanocomposites via supercritical antisolvent process for improved antidepression therapy. Regen Biomater 9. https:\/\/doi.org\/10.1093\/RB\/RBAC080","DOI":"10.1093\/RB\/RBAC080"},{"issue":"1","key":"5940_CR63","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/S12929-024-01055-0","volume":"31","author":"YF Chen","year":"2024","unstructured":"Chen YF, Luh F, Ho YS, Yen Y (2024) Exosomes: a review of biologic function, diagnostic and targeted therapy applications, and clinical trials. J Biomed Sci 31(1):67. https:\/\/doi.org\/10.1186\/S12929-024-01055-0","journal-title":"J Biomed Sci"},{"key":"5940_CR64","doi-asserted-by":"publisher","unstructured":"Chen B, Luo M, Liang J, Zhang C, Chen B, Luo M, Liang J, Zhang C, Gao C, Wang J, Wang J, Li Y, Xu D, Liu L, Zhang N (2018) Surface modification of PGP for a neutrophil\u2013nanoparticle co-vehicle to enhance the anti-depressant effect of baicalein. Acta Pharm Sin B 8(1):64\u201373. https:\/\/doi.org\/10.1016\/j.apsb.2017.11.012","DOI":"10.1016\/j.apsb.2017.11.012"},{"key":"5940_CR65","doi-asserted-by":"publisher","unstructured":"Cheshmehnoor P, Bolourchian N, Abdollahizad E, Derakhshi A, Dadashzadeh S, Haeri A (2023) Particle size tailoring of quercetin nanosuspensions by wet media milling technique: a study on processing and formulation parameters. Iranian Journal of Pharmaceutical Research: IJPR 21(1):e130626. https:\/\/doi.org\/10.5812\/IJPR-130626","DOI":"10.5812\/IJPR-130626"},{"key":"5940_CR66","doi-asserted-by":"publisher","unstructured":"Chiarentin R, Bottcher DP, Zeni B, Grave C, Kaufmann FN, Saraiva TES, Costa Berna G Da, F\u00fchr GA, Hermann BS, Hoffmeister B, Pont Morisso F Dal, Char\u00e3o MF, Verza SG, Fleck JD, Betti AH, de Mattos CB (2024)\u200f Development and pharmacological evaluation of liposomes and nanocapsules containing paroxetine hydrochloride\u200f. Int J Pharm 660:124304. https:\/\/doi.org\/10.1016\/j.ijpharm.2024.124304","DOI":"10.1016\/j.ijpharm.2024.124304"},{"issue":"10","key":"5940_CR67","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.3390\/PHARMACEUTICS17101360","volume":"17","author":"S Cho","year":"2025","unstructured":"Cho S, Rasoulianboroujeni M, Kang RH, Kwon GS (2025) From conventional to next-generation strategies: recent advances in polymeric micelle preparation for drug delivery. Pharm 17(10):1360. https:\/\/doi.org\/10.3390\/PHARMACEUTICS17101360","journal-title":"Pharm"},{"key":"5940_CR68","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/164_2018_133\/TABLES\/2","volume":"250","author":"R Chockalingam","year":"2019","unstructured":"Chockalingam R, Gott BM, Conway CR (2019) Tricyclic antidepressants and monoamine oxidase inhibitors: are they too old for a new look? Handb Exp Pharmacol 250:37\u201348. https:\/\/doi.org\/10.1007\/164_2018_133\/TABLES\/2","journal-title":"Handb Exp Pharmacol"},{"issue":"1","key":"5940_CR69","doi-asserted-by":"publisher","first-page":"4728","DOI":"10.1038\/s41598-023-31895-z","volume":"13","author":"S Choi","year":"2023","unstructured":"Choi S, Kang B, Yang E, Kim K, Kwak MK, Chang PS, Jung HS (2023) Precise control of liposome size using characteristic time depends on solvent type and membrane properties. Sci Rep 13(1):4728. https:\/\/doi.org\/10.1038\/s41598-023-31895-z","journal-title":"Sci Rep"},{"key":"5940_CR70","doi-asserted-by":"publisher","unstructured":"Choi H, Kim JH, Yang HS, Kim JY, Cortese S, Smith L, Koyanagi A, Dragioti E, Radua J, Fusar-Poli P, Shin, J Il, Cheon KA, Solmi M (2024) Pharmacological and non-pharmacological interventions for irritability in autism spectrum disorder: a systematic review and meta-analysis with the GRADE assessment. Mol Autism 15(1): 7-. https:\/\/doi.org\/10.1186\/S13229-024-00585-6","DOI":"10.1186\/S13229-024-00585-6"},{"issue":"5","key":"5940_CR71","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1007\/S13346-018-0552-2","volume":"8","author":"H Choudhury","year":"2018","unstructured":"Choudhury H, Pandey M, Chin PX, Phang YL, Cheah JY, Ooi SC, Mak KK, Pichika MR, Kesharwani P, Hussain Z, Gorain B (2018) Transferrin receptors-targeting nanocarriers for efficient targeted delivery and transcytosis of drugs into the brain tumors: a review of recent advancements and emerging trends. Drug Deliv Transl Res 8(5):1563\u20131545. https:\/\/doi.org\/10.1007\/S13346-018-0552-2","journal-title":"Drug Deliv Transl Res"},{"issue":"1","key":"5940_CR72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neurom.2024.07.008","volume":"28","author":"SS Cox","year":"2025","unstructured":"Cox SS, Connolly DJ, Peng X, Badran BW (2025) A comprehensive review of low-intensity focused ultrasound parameters and applications in neurologic and psychiatric disorders. Neuromodulation: Technology at the Neural Interface 28(1):1\u201315. https:\/\/doi.org\/10.1016\/j.neurom.2024.07.008","journal-title":"Neuromodulation: Technology at the Neural Interface"},{"issue":"1","key":"5940_CR73","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/S40345-024-00356-5","volume":"12","author":"M Coyac","year":"2024","unstructured":"Coyac M, Jalabert L, Decl\u00e8ves X, Etain B, Bellivier F (2024) Relevance of red blood cell Lithium concentration in the management of Lithium-treated bipolar and unipolar disorders: a systematic narrative review. Int J Bipolar Disord 12(1):35. https:\/\/doi.org\/10.1186\/S40345-024-00356-5","journal-title":"Int J Bipolar Disord"},{"issue":"9","key":"5940_CR74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/S11920-016-0717-Y\/METRICS","volume":"18","author":"S Creado","year":"2016","unstructured":"Creado S, Plante DT (2016) An update on the use of sedative-hypnotic medications in psychiatric disorders. Curr Psychiatry Rep 18(9):1\u20137. https:\/\/doi.org\/10.1007\/S11920-016-0717-Y\/METRICS","journal-title":"Curr Psychiatry Rep"},{"key":"5940_CR75","doi-asserted-by":"publisher","unstructured":"Crowe TP, Hsu WH (2022) Evaluation of recent intranasal drug delivery systems to the central nervous system. Pharmaceutics 14(3):629.\u00a0https:\/\/doi.org\/10.3390\/pharmaceutics14030629","DOI":"10.3390\/pharmaceutics14030629"},{"issue":"4","key":"5940_CR76","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/S11011-023-01329-W","volume":"39","author":"K da Costa Rodrigues","year":"2024","unstructured":"da Costa Rodrigues K, da Silva Neto MR, dos Santos Barboza V, Hass SE, de Almeida Vaucher R, Giongo JL, Schumacher RF, Wilhelm EA, Luchese C (2024) New curcumin-loaded nanocapsules as a therapeutic alternative in an amnesia model. Metab Brain Dis 39(4):589\u2013609. https:\/\/doi.org\/10.1007\/S11011-023-01329-W","journal-title":"Metab Brain Dis"},{"key":"5940_CR77","doi-asserted-by":"publisher","unstructured":"D\u0105browska-Bouta B, Sulkowski G, Orzelska-G\u00f3rka J, Stru\u017cy\u0144ska L, K\u0119dzierska E, Bia\u0142a G (2021) Response of immature rats to a low dose of nanoparticulate silver: alterations in behavior, cerebral vasculature-related transcriptome and permeability. Ecotoxicol Environ Saf 208:111416.\u00a0https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111416","DOI":"10.1016\/j.ecoenv.2020.111416"},{"key":"5940_CR78","doi-asserted-by":"publisher","unstructured":"Dadkhah M, Afshari S, Samizadegan T, Shirmard LR, Barin S (2024)\u200f Pegylated chitosan nanoparticles of fluoxetine enhance cognitive performance and hippocampal brain derived neurotrophic factor levels in a rat model of\u200f local demyelination. Exp Gerontol 195:112533. https:\/\/doi.org\/10.1016\/j.exger.2024.112533","DOI":"10.1016\/j.exger.2024.112533"},{"key":"5940_CR79","doi-asserted-by":"publisher","DOI":"10.3389\/FNBEH.2022.844916","author":"C Dalla","year":"2022","unstructured":"Dalla C, Pavlidi P, Sakelliadou DG, Grammatikopoulou T, Kokras N (2022) Sex differences in blood-brain barrier transport of psychotropic drugs. Front Behav Neurosci. https:\/\/doi.org\/10.3389\/FNBEH.2022.844916","journal-title":"Front Behav Neurosci"},{"issue":"3","key":"5940_CR80","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1039\/c8ra06688d","volume":"9","author":"Y Dang","year":"2019","unstructured":"Dang Y, An C, Li Y, Han D, Liu X, Zhang F, Xu Y, Zhong H, Khan M, Khan K, Zou F, Sun X (2019) Neutrophil-mediated and low density lipoprotein receptor-mediated dual-targeting nanoformulation enhances brain accumulation of scutellarin and exerts. RSC Adv 9(3):1299\u20131318. https:\/\/doi.org\/10.1039\/c8ra06688d","journal-title":"RSC Adv"},{"key":"5940_CR81","doi-asserted-by":"publisher","unstructured":"Das M, Sarma A, Baruah H, Basak D (2024) Insight into central nervous system targeted nanostructured lipid carriers via the nose to brain pathway. RSC Pharm 1(5):904\u2013927. https:\/\/doi.org\/10.1039\/D4PM00057A","DOI":"10.1039\/D4PM00057A"},{"key":"5940_CR82","doi-asserted-by":"publisher","unstructured":"Dasari NAGASEN, Balla SUJIYA, Kondrapu PYDIRAJU, Gummadi RAMAKRISHNA, Surada NOOKARAJU, Kondru UM, Pindiprolu SK (2023) Targeting angiogenesis with fluphenazine-zinc oxide nanoconjugates: a potential mechanism for improving antipsychotic efficacy. Int J Appl Pharmaceutics 15:339\u2013343. https:\/\/doi.org\/10.22159\/ijap.2023v15i5.48317\u200f","DOI":"10.22159\/ijap.2023v15i5.48317"},{"key":"5940_CR83","doi-asserted-by":"publisher","unstructured":"Davidson B, Schmidt FA, Bichsel O, Hajiabadi MM, Lozano AM (2025) Transcranial focused ultrasound: a transformative tool for intracranial ablation, drug delivery, and neuromodulation. IEEE Rev Biomed Eng. https:\/\/doi.org\/10.1109\/RBME.2025.3624970","DOI":"10.1109\/RBME.2025.3624970"},{"issue":"11","key":"5940_CR84","doi-asserted-by":"publisher","first-page":"4000","DOI":"10.3390\/JCM14114000\/S1","volume":"14","author":"C De Domenico","year":"2025","unstructured":"De Domenico C, Alito A, Leonardi G, Pironti E, Di Cara M, Piccolo A, Settimo C, Quartarone A, Gagliano A, Cucinotta F (2025) Children and adolescents with co-occurring attention-deficit\/hyperactivity disorder and autism spectrum disorder: a systematic review of multimodal interventions. J Clin Med 14(11):4000. https:\/\/doi.org\/10.3390\/JCM14114000\/S1","journal-title":"J Clin Med"},{"key":"5940_CR85","doi-asserted-by":"publisher","unstructured":"de Ferreira JG, J, Flores VG, Marco MR, Fraga BB, Zorzo RR, de Morais P da F, Morisso FDP, Fleck J D, Char\u00e3o MF, de Mattos CB, Betti AH (2024) Diazepam nanocapsules as an alternative for sleep induction: development study and toxicity assessment. Food Chem Toxicol 192:114962. https:\/\/doi.org\/10.1016\/J.FCT.2024.114962","DOI":"10.1016\/J.FCT.2024.114962"},{"key":"5940_CR86","doi-asserted-by":"publisher","unstructured":"de Freitas Ara\u00fajo Reis MY, de Ara\u00fajo R\u00eago RI, Rocha BP, Guedes GG, de Medeiros Ramalho \u00cdM, de Medeiros Cavalcanti AL, Guimar\u00e3es GP, de Lima Damasceno BPG (2021) A general approach on surfactants use and properties in drug delivery systems. Curr Pharm Des 27(42):4300\u20134314. https:\/\/doi.org\/10.2174\/1381612827666210526091825","DOI":"10.2174\/1381612827666210526091825"},{"key":"5940_CR87","doi-asserted-by":"publisher","unstructured":"Deng S, Gigliobianco MR, Censi R, Martino PD (2020) Polymeric nanocapsules as nanotechnological alternative for drug delivery system: current status, challenges and opportunities. Nanomaterials (Basel) 10(5):847.\u00a0https:\/\/doi.org\/10.3390\/nano10050847","DOI":"10.3390\/nano10050847"},{"key":"5940_CR88","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.2147\/IJN.S397650","volume":"18","author":"L Deruyver","year":"2023","unstructured":"Deruyver L, Rigaut C, Gomez-Perez A, Lambert P, Haut B, Goole J (2023) In vitro evaluation of paliperidone palmitate loaded cubosomes effective for nasal-to-brain delivery. Int J Nanomedicine 18:1085\u20131106. https:\/\/doi.org\/10.2147\/IJN.S397650","journal-title":"Int J Nanomedicine"},{"key":"5940_CR89","doi-asserted-by":"publisher","first-page":"1395867","DOI":"10.3389\/FPHAR.2024.1395867\/FULL","volume":"15","author":"ML Dessus-Gilbert","year":"2024","unstructured":"Dessus-Gilbert ML, Nourredine M, Zimmer L, Rolland B, Geoffray MM, Auffret M, Jurek L (2024) NMDA antagonist agents for the treatment of symptoms in autism spectrum disorder: a systematic review and meta-analysis. Front Pharmacol 15:1395867. https:\/\/doi.org\/10.3389\/FPHAR.2024.1395867\/FULL","journal-title":"Front Pharmacol"},{"issue":"3","key":"5940_CR90","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1007\/S13346-024-01716-5","volume":"15","author":"M Dias","year":"2025","unstructured":"Dias M, Zhang R, Lammers T, Pallares RM (2025) Clinical translation and landscape of silver nanoparticles. Drug Deliv Transl Res 15(3):789\u2013797. https:\/\/doi.org\/10.1007\/S13346-024-01716-5","journal-title":"Drug Deliv Transl Res"},{"issue":"2","key":"5940_CR91","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/J.IJPHARM.2017.05.051","volume":"533","author":"SM \u0110or\u0111evi\u0107","year":"2017","unstructured":"\u0110or\u0111evi\u0107 SM, Santra\u010d A, Ceki\u0107 ND, Markovi\u0107 BD, Divovi\u0107 B, Ili\u0107 TM, Savi\u0107 MM, Savi\u0107 SD (2017) Parenteral nanoemulsions of risperidone for enhanced brain delivery in acute psychosis: physicochemical and in vivo performances. Int J Pharm 533(2):421\u2013430. https:\/\/doi.org\/10.1016\/J.IJPHARM.2017.05.051","journal-title":"Int J Pharm"},{"key":"5940_CR92","doi-asserted-by":"publisher","unstructured":"dos Santos Rodrigues B, Arora S, Kanekiyo T, Singh J (2020) Efficient neuronal targeting and transfection using RVG and transferrin-conjugated liposomes. Brain Res 1734. https:\/\/doi.org\/10.1016\/j.brainres.2020.146738","DOI":"10.1016\/j.brainres.2020.146738"},{"issue":"1","key":"5940_CR93","doi-asserted-by":"publisher","DOI":"10.1186\/S40035-025-00481-W","volume":"14","author":"I Drath","year":"2025","unstructured":"Drath I, Richter F, Feja M (2025) Nose-to-brain drug delivery: from bench to bedside. Transl Neurodegener 14(1):23. https:\/\/doi.org\/10.1186\/S40035-025-00481-W","journal-title":"Transl Neurodegener"},{"key":"5940_CR94","doi-asserted-by":"publisher","unstructured":"Du Q, Liu Y, Fan M, Wei S, Ismail M, Zheng M (2024) PEG length effect of peptide-functional liposome for blood brain barrier (BBB) penetration and brain targeting. J Control Release 372:85\u201394.\u00a0https:\/\/doi.org\/10.1016\/j.jconrel.2024.06.005","DOI":"10.1016\/j.jconrel.2024.06.005"},{"issue":"20","key":"5940_CR95","doi-asserted-by":"publisher","DOI":"10.3390\/MOLECULES25204781","volume":"25","author":"VA Duong","year":"2020","unstructured":"Duong VA, Nguyen TTL, Maeng HJ (2020) Preparation of solid lipid nanoparticles and nanostructured lipid carriers for drug delivery and the effects of preparation parameters of solvent injection method. Molecules 25(20). https:\/\/doi.org\/10.3390\/MOLECULES25204781","journal-title":"Molecules"},{"key":"5940_CR96","doi-asserted-by":"publisher","unstructured":"Dykman L, Khlebtsov B, Khlebtsov N (2025) Drug delivery using gold nanoparticles. Adv Drug Deliv Rev 216. https:\/\/doi.org\/10.1016\/J.ADDR.2024.115481","DOI":"10.1016\/J.ADDR.2024.115481"},{"key":"5940_CR97","doi-asserted-by":"crossref","unstructured":"Ehret MJ, Davis E, Luttrell SE, Clark C (2018) Aripiprazole Lauroxil NanoCrystal \u00ae Dispersion Technology (Aristada Initio \u00ae). Clin Schizophr Relat Psychoses 12(2):92\u201396","DOI":"10.3371\/CSRP.EHDA071918"},{"key":"5940_CR98","doi-asserted-by":"publisher","DOI":"10.1007\/S11033-026-11939-Z","author":"H EL Fatimi","year":"2026","unstructured":"EL Fatimi H, Khalki H, El-Mansoury B, Zaid Y, Khalki L (2026) Benzodiazepines for anxiety and depression: an updated overview of current use and major outcomes. Mol Biol Rep. https:\/\/doi.org\/10.1007\/S11033-026-11939-Z","journal-title":"Mol Biol Rep"},{"issue":"9","key":"5940_CR99","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1007\/S13346-024-01525-W","volume":"14","author":"SN El-Helaly","year":"2024","unstructured":"El-Helaly SN, Rashad AA (2024) Mirtazapine loaded polymeric micelles for rapid release tablet: a novel formulation\u2014In vitro and in vivo studies. Drug Deliv Transl Res 14(9):2498\u20132488. https:\/\/doi.org\/10.1007\/S13346-024-01525-W","journal-title":"Drug Deliv Transl Res"},{"issue":"3","key":"5940_CR100","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1002\/ERV.70070","volume":"34","author":"MP Ellwanger","year":"2026","unstructured":"Ellwanger MP, Pomianoski BW, Vieira DL, Ellwanger MP, Astori V, Messinger MF (2026) Efficacy, safety and tolerability of lisdexamfetamine dimesylate treatment compared with placebo in adults with binge-eating disorder: a systematic review and meta-analysis of randomised controlled trials. European Eating Disorders Review\u202f: the Journal of the Eating Disorders Association 34(3):770\u2013779. https:\/\/doi.org\/10.1002\/ERV.70070","journal-title":"European Eating Disorders Review : the Journal of the Eating Disorders Association"},{"key":"5940_CR101","doi-asserted-by":"publisher","first-page":"12889","DOI":"10.2147\/IJN.S487188","volume":"19","author":"MT El-Saadony","year":"2024","unstructured":"El-Saadony MT, Fang G, Yan S, Alkafaas SS, El Nasharty MA, Khedr SA, Hussien AM, Ghosh S, Dladla M, Elkafas SS, Ibrahim EH, Salem HM, Mosa WFA, Ahmed AE, Mohammed DM, Korma SA, El-Tarabily MK, Saad AM, El-Tarabily KA, Abuqamar SF (2024) Green synthesis of zinc oxide nanoparticles: preparation, characterization, and biomedical applications - a review. Int J Nanomedicine 19:12889\u201312937. https:\/\/doi.org\/10.2147\/IJN.S487188","journal-title":"Int J Nanomedicine"},{"key":"5940_CR102","doi-asserted-by":"publisher","first-page":"9517","DOI":"10.2147\/IJN.S277352","volume":"15","author":"FM Elsenosy","year":"2020","unstructured":"Elsenosy FM, Abdelbary GA, Elshafeey AH, Elsayed I, Fares AR (2020) Brain targeting of duloxetine HCL via intranasal delivery of loaded cubosomal gel: in vitro characterization, ex vivo permeation, and in vivo biodistribution studies. Int J Nanomedicine 15:9517\u20139537. https:\/\/doi.org\/10.2147\/IJN.S277352","journal-title":"Int J Nanomedicine"},{"issue":"11","key":"5940_CR103","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.3390\/PHARMACEUTICS13111869","volume":"13","author":"AH Elshafeey","year":"2021","unstructured":"Elshafeey AH, El-Dahmy RM (2021) Formulation and development of oral fast-dissolving films loaded with nanosuspension to augment paroxetine bioavailability: in vitro characterization, ex vivo permeation, and pharmacokinetic evaluation in healthy human volunteers. Pharm 13(11):1869. https:\/\/doi.org\/10.3390\/PHARMACEUTICS13111869","journal-title":"Pharm"},{"key":"5940_CR104","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.2147\/IJN.S403707","volume":"18","author":"FM Elsharkawy","year":"2023","unstructured":"Elsharkawy FM, Amin MM, Shamsel-Din HA, Ibrahim W, Ibrahim AB, Sayed S (2023) Self-assembling lecithin-based mixed polymeric micelles for nose to brain delivery of clozapine: in-vivo assessment of drug efficacy via radiobiological evaluation. Int J Nanomedicine 18:1577\u20131595. https:\/\/doi.org\/10.2147\/IJN.S403707","journal-title":"Int J Nanomedicine"},{"issue":"8","key":"5940_CR105","doi-asserted-by":"publisher","first-page":"3698","DOI":"10.1208\/S12249-018-1180-3","volume":"19","author":"SM Etman","year":"2018","unstructured":"Etman SM, Elnaggar YSR, Abdelmonsif DA, Abdallah OY (2018) Oral brain-targeted microemulsion for enhanced piperine delivery in Alzheimer\u2019s disease therapy: in vitro appraisal, in vivo activity, and nanotoxicity. AAPS Pharmscitech 19(8):3698\u20133711. https:\/\/doi.org\/10.1208\/S12249-018-1180-3","journal-title":"AAPS Pharmscitech"},{"issue":"6","key":"5940_CR106","doi-asserted-by":"publisher","first-page":"2630","DOI":"10.1007\/S12011-023-03849-Z","volume":"202","author":"HM Fahmy","year":"2023","unstructured":"Fahmy HM, Aboalasaad FA, Mohamed AS, Elhusseiny FA, Khadrawy YA, Elmekawy A (2023) Evaluation of the therapeutic effect of curcumin-conjugated zinc oxide nanoparticles on reserpine-induced depression in Wistar rats. Biol Trace Elem Res 202(6):2630\u20132644. https:\/\/doi.org\/10.1007\/S12011-023-03849-Z","journal-title":"Biol Trace Elem Res"},{"key":"5940_CR107","doi-asserted-by":"publisher","unstructured":"Fahmy HM, Khadrawy YA, Abd-El Daim TM, Elfeky AS, Abd Rabo AA, Mustafa AB (2020) Thymoquinone-encapsulated chitosan nanoparticles coated with polysorbate 80 as a novel treatment agent in a reserpine-induced depression animal model. \u200fPhysiol Behav\u200f. https:\/\/doi.org\/10.1016\/j.physbeh.2020.112934","DOI":"10.1016\/j.physbeh.2020.112934"},{"key":"5940_CR108","doi-asserted-by":"publisher","unstructured":"Faghihi S, Awadi MR, Mousavi SE, Sorkhabadi SMR, Karboni M, Azarmi S, Ghaffari S (2020)\u200f Diazepam loaded solid lipid nanoparticles: in vitro and in vivo evaluations\u200f. Adv Pharm Bull 12(1):86\u201392. https:\/\/doi.org\/10.34172\/apb.2022.008","DOI":"10.34172\/apb.2022.008"},{"issue":"8","key":"5940_CR109","doi-asserted-by":"publisher","first-page":"895","DOI":"10.3390\/COATINGS11080895\/S1","volume":"11","author":"Q Fan","year":"2021","unstructured":"Fan Q, Dehankar A, Porter TK, Winter JO (2021) Effect of micelle encapsulation on toxicity of CdSe\/ZnS and Mn-doped ZnSe quantum dots. Coatings 11(8):895. https:\/\/doi.org\/10.3390\/COATINGS11080895\/S1","journal-title":"Coatings"},{"key":"5940_CR110","doi-asserted-by":"publisher","DOI":"10.1016\/J.MOLLIQ.2021.116306","volume":"336","author":"RK Farahani","year":"2021","unstructured":"Farahani RK, Bagheri A (2021) Mixed micelle formation between a surface active ionic liquid and tricyclic antidepressant drugs (imipramine hydrochloride and amitriptyline hydrochloride). J Mol Liq 336. https:\/\/doi.org\/10.1016\/J.MOLLIQ.2021.116306","journal-title":"J Mol Liq"},{"key":"5940_CR111","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.2147\/DDDT.S102500","volume":"11","author":"AM Fatouh","year":"2017","unstructured":"Fatouh AM, Elshafeey AH, Abdelbary A (2017) Intranasal agomelatine solid lipid nanoparticles to enhance brain delivery: formulation, optimization and in vivo pharmacokinetics. Drug Des Devel Ther 11:1825\u20131815. https:\/\/doi.org\/10.2147\/DDDT.S102500","journal-title":"Drug Des Devel Ther"},{"key":"5940_CR112","doi-asserted-by":"publisher","unstructured":"Feng X, Jia P, Zhang D (2024) Nanocarrier drug delivery system: promising platform for targeted depression therapy. Front Pharmacol 15:1435133. https:\/\/doi.org\/10.3389\/FPHAR.2024.1435133","DOI":"10.3389\/FPHAR.2024.1435133"},{"issue":"4","key":"5940_CR113","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1055\/S-0044-1787571","volume":"44","author":"DC Fipps","year":"2024","unstructured":"Fipps DC, Oesterle TS, Kolla BP (2024) Opioid maintenance therapy: a review of methadone, buprenorphine, and naltrexone treatments for opioid use disorder. Semin Neurol 44(4):441\u2013451. https:\/\/doi.org\/10.1055\/S-0044-1787571","journal-title":"Semin Neurol"},{"key":"5940_CR114","doi-asserted-by":"publisher","first-page":"7415","DOI":"10.2147\/IJN.S265061","volume":"15","author":"DK Flak","year":"2020","unstructured":"Flak DK, Adamski V, Nowaczyk G, Szutkowski K, Synowitz M, Jurga S, Held-Feindt J (2020) At101-loaded cubosomes as an alternative for improved glioblastoma therapy. Int J Nanomed 15:7415\u20137431. https:\/\/doi.org\/10.2147\/IJN.S265061","journal-title":"Int J Nanomed"},{"issue":"Supplement_1","key":"5940_CR115","doi-asserted-by":"publisher","first-page":"i267","DOI":"10.1093\/IJNP\/PYAE059.472","volume":"28","author":"R Freire","year":"2025","unstructured":"Freire R, Fidry M, Faria C, Cabo M, Matos U, Steffen R, Nardi A (2025) Safety and efficacy of monoamine oxidase inhibitors in the treatment of anxiety disorders: a systematic review and meta-analysis. Int J Neuropsychopharmacol 28(Supplement_1):i267\u2013i268. https:\/\/doi.org\/10.1093\/IJNP\/PYAE059.472","journal-title":"Int J Neuropsychopharmacol"},{"issue":"1","key":"5940_CR116","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/S12011-023-03644-W","volume":"202","author":"J Fujihara","year":"2024","unstructured":"Fujihara J, Nishimoto N (2024) Review of zinc oxide nanoparticles: toxicokinetics, tissue distribution for various exposure routes, toxicological effects, toxicity mechanism in mammals, and an approach for toxicity reduction. Biol Trace Elem Res 202(1):9\u201323. https:\/\/doi.org\/10.1007\/S12011-023-03644-W","journal-title":"Biol Trace Elem Res"},{"key":"5940_CR117","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJPHARM.2023.123566","volume":"648","author":"D Gadhave","year":"2023","unstructured":"Gadhave D, Quadros M, Ugale AR, Goyal M, Gupta V (2023) A nanoemulgel for nose-to-brain delivery of quetiapine \u2013 QbD-enabled formulation development & in-vitro characterization. Int J Pharm 648. https:\/\/doi.org\/10.1016\/J.IJPHARM.2023.123566","journal-title":"Int J Pharm"},{"key":"5940_CR118","doi-asserted-by":"publisher","unstructured":"Gadhave DG et al (2024) Mucoadhesive chitosan-poly (lactic-co-glycolic acid) nanoparticles for intranasal delivery of quetiapine\u2013Development & characterization in physiologically relevant 3D tissue models. Int J Biol Macromol 267:131491. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.131491","DOI":"10.1016\/j.ijbiomac.2024.131491"},{"key":"5940_CR119","doi-asserted-by":"publisher","unstructured":"Gajbhiye KR, Pawar A, Mahadik KR, Gajbhiye V (2020)\u200f PEGylated nanocarriers: a promising tool for targeted delivery to the brain\u200f. Colloids Surf B: Biointerfaces 187:110770. https:\/\/doi.org\/10.1016\/j.colsurfb.2019.110770","DOI":"10.1016\/j.colsurfb.2019.110770"},{"key":"5940_CR120","doi-asserted-by":"publisher","unstructured":"G\u00e4nger S, Schindowski K (2018) Tailoring formulations for intranasal nose-to-brain delivery: a review on architecture, physico-chemical characteristics and mucociliary clearance of the nasal. Pharm 10(3):116\u200f. https:\/\/doi.org\/10.3390\/pharmaceutics10030116","DOI":"10.3390\/pharmaceutics10030116"},{"issue":"3","key":"5940_CR121","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/S40005-020-00482-Z","volume":"50","author":"M Gao","year":"2020","unstructured":"Gao M, Shen X, Mao S (2020) Factors influencing drug deposition in the nasal cavity upon delivery via nasal sprays. J Pharm Inv 50(3):251\u2013259. https:\/\/doi.org\/10.1007\/S40005-020-00482-Z","journal-title":"J Pharm Inv"},{"issue":"3","key":"5940_CR122","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1038\/S41565-023-01551-8","volume":"19","author":"J Gao","year":"2024","unstructured":"Gao J, Song Q, Gu X, Jiang G, Huang J, Tang Y, Yu R, Wang A, Huang Y, Zheng G, Chen H, Gao X (2024) Intracerebral fate of organic and inorganic nanoparticles is dependent on microglial extracellular vesicle function. Nat Nanotechnol 19(3):386\u2013376. https:\/\/doi.org\/10.1038\/S41565-023-01551-8","journal-title":"Nat Nanotechnol"},{"key":"5940_CR123","doi-asserted-by":"publisher","unstructured":"Gastaldo-Jord\u00e1n I, Villalba-Pita C, Mart\u00ednez-Raga J, Sanz Y, Medina-Rodr\u00edguez EM\u00a0(2025) Are conventional antidepressants enough? The gut microbiome and nanocarrier-based delivery systems as future prospects for depression treatment.\u00a0Neurosci Biobehav Rev\u00a0106421.\u00a0https:\/\/doi.org\/10.1016\/j.neubiorev.2025.106421","DOI":"10.1016\/j.neubiorev.2025.106421"},{"key":"5940_CR124","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S600278","author":"X Ge","year":"2026","unstructured":"Ge X, Zhao L, Xing X, Hao Y, Zhang Z, Sun G (2026) Harnessing nanocarriers to improve psychiatric treatment: progress, limitations, and future directions. Int J Nanomedicine. https:\/\/doi.org\/10.2147\/IJN.S600278","journal-title":"Int J Nanomedicine"},{"key":"5940_CR125","doi-asserted-by":"publisher","unstructured":"Gencturk S, Unal G (2024)\u200f Rodent tests of depression and anxiety: construct validity and translational relevance\u200f.\u200f Cogn Affect Behav Neurosci 24(2): 191\u2013224. https:\/\/doi.org\/10.3758\/S13415-024-01171-2","DOI":"10.3758\/S13415-024-01171-2"},{"key":"5940_CR126","doi-asserted-by":"publisher","unstructured":"Georgeous J, AlSawaftah N, Abuwatfa WH, Husseini GA (2024) Review of gold nanoparticles: synthesis, properties, shapes, cellular uptake, targeting, release mechanisms and applications in drug delivery and therapy. Pharm 16(10). https:\/\/doi.org\/10.3390\/PHARMACEUTICS16101332","DOI":"10.3390\/PHARMACEUTICS16101332"},{"issue":"17","key":"5940_CR127","doi-asserted-by":"publisher","DOI":"10.3390\/POLYM16172536","volume":"16","author":"M Geszke-Moritz","year":"2024","unstructured":"Geszke-Moritz M, Moritz M (2024) Biodegradable polymeric nanoparticle-based drug delivery systems: comprehensive overview, perspectives and challenges. Polymers (Basel) 16(17). https:\/\/doi.org\/10.3390\/POLYM16172536","journal-title":"Polymers (Basel)"},{"key":"5940_CR128","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.jconrel.2021.02.031","volume":"332","author":"M Ghezzi","year":"2021","unstructured":"Ghezzi M, Pescina S, Padula C, Santi P, Del Favero E, Cant\u00f9 L, Nicoli S (2021) Polymeric micelles in drug delivery: an insight of the techniques for their characterization and assessment in biorelevant conditions. J Control Release 332:312\u2013336. https:\/\/doi.org\/10.1016\/j.jconrel.2021.02.031","journal-title":"J Control Release"},{"key":"5940_CR129","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/J.JCONREL.2021.02.016","volume":"332","author":"B Ghosh","year":"2021","unstructured":"Ghosh B, Biswas S (2021) Polymeric micelles in cancer therapy: state of the art. J Control Release 332:127\u2013147. https:\/\/doi.org\/10.1016\/J.JCONREL.2021.02.016","journal-title":"J Control Release"},{"key":"5940_CR130","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ymeth.2021.05.003","volume":"199","author":"E Gomaa","year":"2022","unstructured":"Gomaa E, Fathi HA, Eissa NG, Elsabahy M (2022) Methods for preparation of nanostructured lipid carriers. Methods 199:3\u20138. https:\/\/doi.org\/10.1016\/j.ymeth.2021.05.003","journal-title":"Methods"},{"key":"5940_CR131","doi-asserted-by":"publisher","first-page":"e085875","DOI":"10.1136\/BMJ-2025-085875","volume":"391","author":"CJ Gosling","year":"2025","unstructured":"Gosling CJ, Garcia-Argibay M, De Prisco M, Arrondo G, Ayrolles A, Antoun S, Caparos S, Catal\u00e1n A, Ellul P, Dobrosavljevic M, Farhat LC, Fico G, Eudave L, Groenman AP, H\u00f8jlund M, Jurek L, Nourredine M, Oliva V, Parlatini V, Psyllou C, Salazar-de-Pablo G, Tomlinson A, Westwood SJ, Cipriani A, Correll CU, Yon DK, Larsson H, Ostinelli EG, Il Shin J, Fusar-Poli P, Ioannidis JPA, Radua J, Solmi M, Delorme R, Cortese S (2025) Benefits and harms of ADHD interventions: umbrella review and platform for shared decision making. BMJ (Clin Res Ed.) 391:e085875. https:\/\/doi.org\/10.1136\/BMJ-2025-085875","journal-title":"BMJ (Clin Res Ed.)"},{"key":"5940_CR132","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PMED.1003664","author":"NP Gosmann","year":"2021","unstructured":"Gosmann NP, De Abreu Costa M, De Barros Jaeger M, Motta LS, Frozi J, Spanemberg L, Manfro GG, Cuijpers P, Pine DS, Salum GA (2021) Selective serotonin reuptake inhibitors, and serotonin and norepinephrine reuptake inhibitors for anxiety, obsessive-compulsive, and stress disorders: a 3-level network meta-analysis. PLoS Med. https:\/\/doi.org\/10.1371\/JOURNAL.PMED.1003664","journal-title":"PLoS Med"},{"key":"5940_CR133","doi-asserted-by":"publisher","DOI":"10.1016\/J.ENVRES.2023.116894","volume":"237","author":"BHJ Gowda","year":"2023","unstructured":"Gowda BHJ, Ahmed MG, Alshehri SA, Wahab S, Vora LK, Singh Thakur RR, Kesharwani P (2023) The cubosome-based nanoplatforms in cancer therapy: seeking new paradigms for cancer theranostics. Environ Res 237. https:\/\/doi.org\/10.1016\/J.ENVRES.2023.116894","journal-title":"Environ Res"},{"issue":"1","key":"5940_CR134","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/WPS.21172","volume":"23","author":"B Gray","year":"2024","unstructured":"Gray B, Asrat B, Brohan E, Chowdhury N, Dua T, van Ommeren M (2024) Management of generalized anxiety disorder and panic disorder in general health care settings: new WHO recommendations. World Psychiatry 23(1):161\u2013160. https:\/\/doi.org\/10.1002\/WPS.21172","journal-title":"World Psychiatry"},{"key":"5940_CR135","doi-asserted-by":"publisher","unstructured":"Gul M, Shah FA, Sahar N. us, Malik I, Din F ud, Khan SA, Aman W, Choi HI, Lim CW, Noh HY, Noh JS, Zeb A, Kim JK (2022) Formulation optimization, in vitro and in vivo evaluation of agomelatine-loaded nanostructured lipid carriers for augmented antidepressant effects. Colloids Surf B: Biointerfaces 216:112537. https:\/\/doi.org\/10.1016\/J.COLSURFB.2022.112537","DOI":"10.1016\/J.COLSURFB.2022.112537"},{"key":"5940_CR136","doi-asserted-by":"publisher","DOI":"10.1016\/J.EBIOM.2025.106054","volume":"122","author":"Z Guo","year":"2025","unstructured":"Guo Z, Liu D, Zhang H, Yu W, Li Y, Gu N (2025) Superparamagnetic iron oxide nanoparticles in clinical applications: current status and future perspectives. EBioMedicine 122:106054. https:\/\/doi.org\/10.1016\/J.EBIOM.2025.106054","journal-title":"EBioMedicine"},{"issue":"4","key":"5940_CR137","doi-asserted-by":"publisher","first-page":"1803335","DOI":"10.1038\/s41578-024-00658-1","volume":"31","author":"M Hadjidemetriou","year":"2019","unstructured":"Hadjidemetriou M, McAdam S, Garner G, Thackeray C, Knight D, Smith D, \u2026 Kostarelos K (2019) The human in vivo biomolecule corona onto PEGylated liposomes: a proof-of-concept clinical study. Adv Mater 31(4):1803335. https:\/\/doi.org\/10.1038\/s41578-024-00658-1","journal-title":"Adv Mater"},{"key":"5940_CR138","doi-asserted-by":"publisher","DOI":"10.31351\/vol29iss1pp62-75","author":"H Hamed","year":"2020","unstructured":"Hamed H (2020) Preparation, in vitro and ex-vivo evaluation of mirtazapine nanosuspension and nanoparticles incorporated in orodispersible tablets. Iraqi Journal of Pharmaceutical Sciences (P-ISSN: 1683 - 3597 , E-ISSN\u202f: 2521 - 3512). https:\/\/doi.org\/10.31351\/vol29iss1pp62-75","journal-title":"Iraqi Journal of Pharmaceutical Sciences (P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512)"},{"key":"5940_CR139","doi-asserted-by":"publisher","DOI":"10.3390\/NANO14110903","author":"Y Han","year":"2024","unstructured":"Han Y, Zhang L, Yang W (2024) Synthesis of mesoporous silica using the sol-gel approach: adjusting architecture and composition for novel applications. Nanomaterials (Basel). https:\/\/doi.org\/10.3390\/NANO14110903","journal-title":"Nanomaterials (Basel)"},{"issue":"22","key":"5940_CR140","doi-asserted-by":"publisher","first-page":"11121","DOI":"10.3390\/ijms262211121","volume":"26","author":"Y Han","year":"2025","unstructured":"Han Y, Kim DH, Pack SP (2025) Nanomaterials in drug delivery: leveraging artificial intelligence and big data for predictive design. Int J Mol Sci 26(22):11121. https:\/\/doi.org\/10.3390\/ijms262211121","journal-title":"Int J Mol Sci"},{"issue":"1","key":"5940_CR141","doi-asserted-by":"publisher","DOI":"10.1186\/S13722-024-00448-8","volume":"19","author":"LY Haque","year":"2024","unstructured":"Haque LY, Zuluaga P, Muga R, Fuster D (2024) Treatment of alcohol use disorder in patients with alcohol-associated liver disease: innovative approaches and a call to action. Addict Sci Clin Pract 19(1):19. https:\/\/doi.org\/10.1186\/S13722-024-00448-8","journal-title":"Addict Sci Clin Pract"},{"key":"5940_CR142","doi-asserted-by":"publisher","first-page":"204512531985996","DOI":"10.1177\/2045125319859964","volume":"9","author":"ML Hard","year":"2019","unstructured":"Hard ML, Wehr A, von Moltke L, Du Y, Farwick S, Walling DP, Sonnenberg J (2019) Pharmacokinetics and safety of deltoid or gluteal injection of aripiprazole lauroxil NanoCrystal\u00ae Dispersion used for initiation of the long-acting antipsychotic. Ther Adv Psychopharmacol 9:2045125319859964. https:\/\/doi.org\/10.1177\/2045125319859964","journal-title":"Ther Adv Psychopharmacol"},{"key":"5940_CR143","doi-asserted-by":"publisher","unstructured":"Harini K, Alomar SY, Vajagathali M, Manoharadas S, Thirumalai A, Girigoswami K, Girigoswami A (2024) Niosomal bupropion: exploring therapeutic frontiers through behavioral profiling. Pharmaceuticals (Basel) 17(3):366.\u00a0https:\/\/doi.org\/10.3390\/ph17030366","DOI":"10.3390\/ph17030366"},{"issue":"12","key":"5940_CR144","doi-asserted-by":"publisher","first-page":"8072","DOI":"10.15419\/z5q8dv72","volume":"12","author":"K Harini","year":"2025","unstructured":"Harini K, Durgadevi P, Girigoswami K, Girigoswami A (2025) Transitioning from conventional therapies to nanomedicine-based therapeutics for major depressive disorder. Biomed Res Ther 12(12):8072\u20138099. https:\/\/doi.org\/10.15419\/z5q8dv72","journal-title":"Biomed Res Ther"},{"issue":"6","key":"5940_CR145","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1007\/S13346-023-01482-W","volume":"14","author":"N Hartl","year":"2023","unstructured":"Hartl N, Gabold B, Uhl P, Kromer A, Xiao X, Fricker G, Mier W, Liu R, Merkel OM (2023) ApoE\u2014functionalization of nanoparticles for targeted brain delivery\u2014a feasible method for polyplexes? Drug Deliv Transl Res 14(6):1660\u20131677. https:\/\/doi.org\/10.1007\/S13346-023-01482-W","journal-title":"Drug Deliv Transl Res"},{"issue":"7","key":"5940_CR146","doi-asserted-by":"publisher","first-page":"498","DOI":"10.7326\/0003-4819-157-7-201210020-00525","volume":"157","author":"L Hartling","year":"2012","unstructured":"Hartling L, Abou-Setta AM, Dursun S, Mousavi SS, Pasichnyk D, Newton AS (2012) Antipsychotics in adults with schizophrenia: comparative effectiveness of first-generation versus second-generation medications: a systematic review and meta-analysis. Ann Intern Med 157(7):498\u2013511. https:\/\/doi.org\/10.7326\/0003-4819-157-7-201210020-00525","journal-title":"Ann Intern Med"},{"key":"5940_CR147","doi-asserted-by":"publisher","unstructured":"Hashemi SH, Montazer M, Naghdi N, Toliyat T (2020) Formulation and characterization of alprazolam transdermal gel based on nanoliposomes.\u200f https:\/\/doi.org\/10.29252\/iau.30.4.376","DOI":"10.29252\/iau.30.4.376"},{"issue":"11","key":"5940_CR148","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.3390\/PHARMACEUTICS13111869","volume":"13","author":"A Hassen Elshafeey","year":"2021","unstructured":"Hassen Elshafeey A, Moataz El-Dahmy R, Khutoryanskiy V, Al-Obaidi H (2021) Formulation and development of oral fast-dissolving films loaded with nanosuspension to augment paroxetine bioavailability: in vitro characterization, ex vivo permeation, and pharmacokinetic evaluation in healthy human volunteers. Pharm 13(11):1869. https:\/\/doi.org\/10.3390\/PHARMACEUTICS13111869","journal-title":"Pharm"},{"issue":"1","key":"5940_CR149","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/S11671-024-04118-1","volume":"19","author":"U Havelikar","year":"2024","unstructured":"Havelikar U, Ghorpade KB, Kumar A, Patel A, Singh M, Banjare N, Gupta PN (2024) Comprehensive insights into mechanism of nanotoxicity, assessment methods and regulatory challenges of nanomedicines. Discov Nano 19(1):165. https:\/\/doi.org\/10.1186\/S11671-024-04118-1","journal-title":"Discov Nano"},{"key":"5940_CR150","doi-asserted-by":"publisher","first-page":"4975","DOI":"10.2147\/IJN.S109088","volume":"11","author":"X He","year":"2016","unstructured":"He X, Zhu Y, Wang M, Jing G, Zhu R, Wang S (2016) Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression. Int J Nanomedicine 11:4975\u20134990. https:\/\/doi.org\/10.2147\/IJN.S109088","journal-title":"Int J Nanomedicine"},{"issue":"3","key":"5940_CR151","doi-asserted-by":"publisher","first-page":"E8","DOI":"10.3171\/2024.6.FOCUS24278","volume":"57","author":"MC Henn","year":"2024","unstructured":"Henn MC, Smith HD, Ramos CGL, Shafie B, Abaricia J, Stevens I, \u2026 Raslan AM (2024) A systematic review of focused ultrasound for psychiatric disorders: current applications, opportunities, and challenges. Neurosurg Focus 57(3):E8. https:\/\/doi.org\/10.3171\/2024.6.FOCUS24278","journal-title":"Neurosurg Focus"},{"key":"5940_CR152","doi-asserted-by":"publisher","DOI":"10.1016\/J.ONANO.2022.100048","volume":"7","author":"Y Herdiana","year":"2022","unstructured":"Herdiana Y, Wathoni N, Shamsuddin S, Muchtaridi M (2022) Scale-up polymeric-based nanoparticles drug delivery systems: development and challenges. OpenNano 7. https:\/\/doi.org\/10.1016\/J.ONANO.2022.100048","journal-title":"OpenNano"},{"issue":"1","key":"5940_CR153","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/S13643-024-02570-9","volume":"13","author":"M Hersi","year":"2024","unstructured":"Hersi M, Beck A, Hamel C, Esmaeilisaraji L, Pussegoda K, Austin B, Ahmadzai N, Pratt M, Thuku M, Yazdi F, Bennett A, Shaver N, Vyas N, Skidmore B, Hutton B, Manuel D, Morrow M, Pakhale S, Presseau J, Shea BJ, Little J, Moher D, Stevens A (2024) Effectiveness of smoking cessation interventions among adults: an overview of systematic reviews. Syst Rev 13(1):179. https:\/\/doi.org\/10.1186\/S13643-024-02570-9","journal-title":"Syst Rev"},{"issue":"3","key":"5940_CR154","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1208\/S12248-008-9055-2","volume":"10","author":"F Herv\u00e9","year":"2008","unstructured":"Herv\u00e9 F, Ghinea N, Scherrmann JM (2008) CNS delivery via adsorptive transcytosis. AAPS J 10(3):455\u2013472. https:\/\/doi.org\/10.1208\/S12248-008-9055-2","journal-title":"AAPS J"},{"issue":"12","key":"5940_CR155","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1038\/JCBFM.2009.104;JOURNAL:JOURNAL:JCBA;PAGEGROUP:STRING:PUBLICATION","volume":"29","author":"R Huang","year":"2009","unstructured":"Huang R, Ke W, Han L, Liu Y, Shao K, Ye L, Lou J, Jiang C, Pei Y (2009) Brain-targeting mechanisms of lactoferrin-modified DNA-loaded nanoparticles. J Cereb Blood Flow Metab 29(12):1914\u20131923. https:\/\/doi.org\/10.1038\/JCBFM.2009.104;JOURNAL:JOURNAL:JCBA;PAGEGROUP:STRING:PUBLICATION","journal-title":"J Cereb Blood Flow Metab"},{"key":"5940_CR156","doi-asserted-by":"publisher","first-page":"1341295","DOI":"10.3389\/FNAGI.2023.1341295\/FULL","volume":"15","author":"Q Huang","year":"2023","unstructured":"Huang Q, Chen X, Yu S, Gong G, Shu H (2023) Research progress in brain-targeted nasal drug delivery. Front Aging Neurosci 15:1341295. https:\/\/doi.org\/10.3389\/FNAGI.2023.1341295\/FULL","journal-title":"Front Aging Neurosci"},{"key":"5940_CR157","doi-asserted-by":"publisher","DOI":"10.3389\/FNMOL.2021.752781\/ENDNOTE","volume":"14","author":"N Hudson","year":"2021","unstructured":"Hudson N, Campbell M (2021) Tight junctions of the neurovascular unit. Front Mol Neurosci 14. https:\/\/doi.org\/10.3389\/FNMOL.2021.752781\/ENDNOTE","journal-title":"Front Mol Neurosci"},{"key":"5940_CR158","doi-asserted-by":"publisher","unstructured":"Huttunen J, Adla SK, Markowicz-Piasecka M, Huttunen KM (2022) Increased\/targeted brain (pro) drug delivery via utilization of solute carriers (SLCs). Pharmaceutics 14(6):1234.\u00a0https:\/\/doi.org\/10.3390\/pharmaceutics14061234","DOI":"10.3390\/pharmaceutics14061234"},{"issue":"9","key":"5940_CR159","doi-asserted-by":"publisher","first-page":"2557","DOI":"10.1007\/S13346-024-01528-7","volume":"14","author":"MM Ibrahim","year":"2024","unstructured":"Ibrahim MM, Basalious EB, El-Nabarawi MA, Makhlouf AIA, Sayyed ME, Ibrahim IT (2024) Nose to brain delivery of mirtazapine via lipid nanocapsules: preparation, statistical optimization, radiolabeling, in vivo biodistribution and pharmacokinetic study. Drug Deliv Transl Res 14(9):2557\u20132539. https:\/\/doi.org\/10.1007\/S13346-024-01528-7","journal-title":"Drug Deliv Transl Res"},{"issue":"2","key":"5940_CR160","doi-asserted-by":"publisher","first-page":"443","DOI":"10.3390\/PHARMACEUTICS15020443","volume":"15","author":"T Ili\u0107","year":"2023","unstructured":"Ili\u0107 T, \u0110okovi\u0107 JB, Nikoli\u0107 I, Mitrovi\u0107 JR, Panteli\u0107 I, Savi\u0107 SD, Savi\u0107 MM (2023) Parenteral lipid-based nanoparticles for CNS disorders: integrating various facets of preclinical evaluation towards more effective clinical translation. Pharm 15(2):443. https:\/\/doi.org\/10.3390\/PHARMACEUTICS15020443","journal-title":"Pharm"},{"key":"5940_CR161","doi-asserted-by":"publisher","unstructured":"Inglut C, Sorrin A, Kuruppu T, Vig S, Cicalo J, Ahmad H, Huang HC (2020) Immunological and toxicological considerations for the design of liposomes. Nanomaterials (Basel) 10(2):190.\u00a0https:\/\/doi.org\/10.3390\/nano10020190","DOI":"10.3390\/nano10020190"},{"key":"5940_CR162","doi-asserted-by":"publisher","unstructured":"Inoue D, Seto Y, To H (2025) Nasal residence depending on the administered dosage form: impact of formulation type on the in vivo nasal retention time of drugs in rats. Pharmaceutics 17(7):863.\u00a0https:\/\/doi.org\/10.3390\/pharmaceutics17070863","DOI":"10.3390\/pharmaceutics17070863"},{"issue":"10","key":"5940_CR163","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.3390\/PHARMACEUTICS16101333","volume":"16","author":"S Jacob","year":"2024","unstructured":"Jacob S, Kather FS, Boddu SHS, Shah J, Nair AB (2024) Innovations in nanoemulsion technology: enhancing drug delivery for oral, parenteral, and ophthalmic applications. Pharm 16(10):1333. https:\/\/doi.org\/10.3390\/PHARMACEUTICS16101333","journal-title":"Pharm"},{"issue":"8","key":"5940_CR164","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3390\/JFB14080433","volume":"14","author":"N Jahan","year":"2023","unstructured":"Jahan N, Kousar F, Rahman KU, Touqeer SI, Abbas N (2023) Development of nanosuspension of Artemisia absinthium extract as novel drug delivery system to enhance its bioavailability and hepatoprotective potential. J Funct Biomater 14(8):433. https:\/\/doi.org\/10.3390\/JFB14080433","journal-title":"J Funct Biomater"},{"key":"5940_CR165","doi-asserted-by":"publisher","unstructured":"Jawad M, Shafique U, Ud Din F, Butt A, Khan S, Khan GM, ... Almerai KS (2024) Nose to brain delivery of escitalopram-loaded nano-structured lipid carriers thermosensitive gel: formulation, physiochemical, pharmacokinetic and pharmacodynamics evaluation.\u00a0J Drug Deliv Sci Technol\u00a097:105800. https:\/\/doi.org\/10.1016\/j.jddst.2024.105800\u200f","DOI":"10.1016\/j.jddst.2024.105800"},{"key":"5940_CR166","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/J.IJBIOMAC.2018.01.121","volume":"110","author":"N Jawahar","year":"2018","unstructured":"Jawahar N, Hingarh PK, Radhakrishnan A, Selvaraj J, Anbarasan A, S S, & G N (2018) Enhanced oral bioavailability of an antipsychotic drug through nanostructured lipid carriers. Int J Biol Macromol 110:269\u2013275. https:\/\/doi.org\/10.1016\/J.IJBIOMAC.2018.01.121","journal-title":"Int J Biol Macromol"},{"key":"5940_CR167","doi-asserted-by":"publisher","DOI":"10.1177\/20451253251342628","volume":"15","author":"Y Jia","year":"2025","unstructured":"Jia Y, Ye Z, Yang F, Chai J, Xu H, Yang J, Liang W, Wu L (2025) Pharmacotherapy for post-traumatic stress disorder: systematic review and meta-analysis. Ther Adv Psychopharmacol 15. https:\/\/doi.org\/10.1177\/20451253251342628","journal-title":"Ther Adv Psychopharmacol"},{"key":"5940_CR168","doi-asserted-by":"publisher","first-page":"101781","DOI":"10.1016\/J.MTBIO.2025.101781","volume":"32","author":"P Jiang","year":"2025","unstructured":"Jiang P, Li J (2025) Recent advances in biomimetic nanodelivery systems for the treatment of depression. Mater Today Bio 32:101781. https:\/\/doi.org\/10.1016\/J.MTBIO.2025.101781","journal-title":"Mater Today Bio"},{"key":"5940_CR169","doi-asserted-by":"publisher","first-page":"115114","DOI":"10.1016\/j.addr.2023.115114","volume":"202","author":"K Jiang","year":"2023","unstructured":"Jiang K, Yu Y, Qiu W, Tian K, Guo Z, Qian J, Lu H, Zhan C (2023) Protein corona on brain targeted nanocarriers: challenges and prospects. Adv Drug Deliv Rev 202:115114. https:\/\/doi.org\/10.1016\/j.addr.2023.115114","journal-title":"Adv Drug Deliv Rev"},{"issue":"9","key":"5940_CR170","doi-asserted-by":"publisher","first-page":"2417869","DOI":"10.1002\/ADMA.202417869;REQUESTEDJOURNAL:JOURNAL:15214095;WGROUP:STRING:PUBLICATION","volume":"37","author":"C Jiang","year":"2025","unstructured":"Jiang C, Yang X, Huang Q, Lei T, Luo H, Wu D, Yang Z, Xu Y, Dou Y, Ma X, Gao H (2025) Microglial-biomimetic memantine-loaded polydopamine nanomedicines for alleviating depression. Adv Mater 37(9):2417869. https:\/\/doi.org\/10.1002\/ADMA.202417869;REQUESTEDJOURNAL:JOURNAL:15214095;WGROUP:STRING:PUBLICATION","journal-title":"Adv Mater"},{"key":"5940_CR171","doi-asserted-by":"publisher","unstructured":"Joseph A, Simo G, Gao T, Alhindi N, Xu N, Graham DJ, Gamble LJ, Nance E (2021) Surfactants influence polymer nanoparticle fate within the brain\u200f. Biomater 277:121086. https:\/\/doi.org\/10.1016\/j.biomaterials.2021.121086","DOI":"10.1016\/j.biomaterials.2021.121086"},{"key":"5940_CR172","doi-asserted-by":"publisher","unstructured":"Joseph E, Reddi S, Rinwa V, Balwani G, Saha R (2017) Design and in vivo evaluation of solid lipid nanoparticulate systems of Olanzapine for acute phase schizophrenia treatment: Investigations on antipsychotic potential and adverse effects.\u00a0Eur J Pharm Sci 104:315\u2013325. https:\/\/doi.org\/10.1016\/j.ejps.2017.03.050\u200f","DOI":"10.1016\/j.ejps.2017.03.050"},{"key":"5940_CR173","doi-asserted-by":"publisher","DOI":"10.1016\/J.PHRS.2025.107876","volume":"219","author":"L Junkes","year":"2025","unstructured":"Junkes L, Quagliato LA, Appolinario JC, Shader RI, Nardi AE (2025) MAO inhibitors for treatment-resistant depression: bringing an updated perspective on pioneering drugs. Pharmacol Res 219. https:\/\/doi.org\/10.1016\/J.PHRS.2025.107876","journal-title":"Pharmacol Res"},{"key":"5940_CR174","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/J.FCT.2018.01.017","volume":"113","author":"S Kaddah","year":"2018","unstructured":"Kaddah S, Khreich N, Kaddah F, Charcosset C, Greige-Gerges H (2018) Cholesterol modulates the liposome membrane fluidity and permeability for a hydrophilic molecule. Food Chem Toxicol 113:40\u201348. https:\/\/doi.org\/10.1016\/J.FCT.2018.01.017","journal-title":"Food Chem Toxicol"},{"issue":"1","key":"5940_CR175","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/S12987-020-00230-3","volume":"17","author":"H Kadry","year":"2020","unstructured":"Kadry H, Noorani B, Cucullo L (2020) A blood\u2013brain barrier overview on structure, function, impairment, and biomarkers of integrity. Fluids Barriers CNS 17(1):69. https:\/\/doi.org\/10.1186\/S12987-020-00230-3","journal-title":"Fluids Barriers CNS"},{"key":"5940_CR176","doi-asserted-by":"publisher","DOI":"10.3389\/FPSYT.2022.831359\/FULL","volume":"13","author":"KG Kahl","year":"2022","unstructured":"Kahl KG, Stapel B, Correll CU (2022) Psychological and psychopharmacological interventions in psychocardiology. Front Psych 13. https:\/\/doi.org\/10.3389\/FPSYT.2022.831359\/FULL","journal-title":"Front Psych"},{"issue":"1","key":"5940_CR177","doi-asserted-by":"publisher","first-page":"e300730","DOI":"10.1136\/bmjment-2023-300730","volume":"27","author":"CB Kamp","year":"2024","unstructured":"Kamp CB, Petersen JJ, Faltermeier P, Juul S, Siddiqui F, Barbateskovic M, \u2026 Jakobsen JC (2024) Beneficial and harmful effects of tricyclic antidepressants for adults with major depressive disorder: a systematic review with meta-analysis and trial sequential analysis. BMJ Mental Health 27(1):e300730. https:\/\/doi.org\/10.1136\/bmjment-2023-300730","journal-title":"BMJ Mental Health"},{"issue":"1","key":"5940_CR178","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/S12888-024-06396-6","volume":"25","author":"CB Kamp","year":"2025","unstructured":"Kamp CB, Petersen JJ, Faltermeier P, Juul S, Sillassen CDB, Siddiqui F, Andersen RK, Moncrieff J, Horowitz MA, Hengartner MP, Kirsch I, Gluud C, Jakobsen JC (2025) The risks of adverse events with mirtazapine for adults with major depressive disorder: a systematic review with meta-analysis and trial sequential analysis. BMC Psychiatry 25(1):67. https:\/\/doi.org\/10.1186\/S12888-024-06396-6","journal-title":"BMC Psychiatry"},{"issue":"6","key":"5940_CR179","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.1007\/S40120-025-00838-3","volume":"14","author":"JM Kane","year":"2025","unstructured":"Kane JM, Agid O, Castle DJ, Citrome L, Fagiolini A, Kishimoto T, Larrauri CA, Leucht S, Rubio JM, Sajatovic M, Schooler N, Correll CU (2025) The use of long-acting injectables for people with schizophrenia: consensus panel recommendations for overcoming barriers and implementing treatment. Neurology and Therapy 14(6):2551\u20132581. https:\/\/doi.org\/10.1007\/S40120-025-00838-3","journal-title":"Neurology and Therapy"},{"issue":"3","key":"5940_CR180","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1021\/acsbiomaterials.5c01998","volume":"12","author":"R Kantesaria","year":"2026","unstructured":"Kantesaria R, Panda HS (2026) A review on AI-based data-driven models for optimization of nanocarriers as drug delivery systems. ACS Biomater Sci Eng 12(3):1397\u20131418. https:\/\/doi.org\/10.1021\/acsbiomaterials.5c01998","journal-title":"ACS Biomater Sci Eng"},{"key":"5940_CR181","doi-asserted-by":"publisher","DOI":"10.53022\/oarjbp.2026.16.2.0020","author":"A Karthikeyan","year":"2026","unstructured":"Karthikeyan A, Avr AR, Balu A, Subramanian G (2026) Intelligent drug delivery in personalized medicine: multi-omics insights, digital simulation, and AI-driven formulation strategies: an illustration. Open Access Res J Biol Pharm. https:\/\/doi.org\/10.53022\/oarjbp.2026.16.2.0020","journal-title":"Open Access Res J Biol Pharm"},{"issue":"2","key":"5940_CR182","doi-asserted-by":"publisher","first-page":"e1756","DOI":"10.1002\/WNAN.1756","volume":"14","author":"LE Kass","year":"2022","unstructured":"Kass LE, Nguyen J (2022) Nanocarrier-hydrogel composite delivery systems for precision drug release. Wiley Interdiscip Rev Nanomed Nanobiotechnol 14(2):e1756. https:\/\/doi.org\/10.1002\/WNAN.1756","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"key":"5940_CR183","doi-asserted-by":"publisher","unstructured":"Kato T, Ogasawara K, Motomura K, Kato M, Tanaka T, Takaesu Y, Nio S, Kishi T, So M, Nemoto K, Suzuki E, Watanabe K, Matsuo K, Watanabe K, Kato T, Matsuo K, Kamimura H, Okai H, Shimode T, \u2026 Yamawaki S (2024) Practice Guidelines for Bipolar Disorder by the JSMD (Japanese Society of Mood Disorders). Psychiatry Clin Neurosci 78(11): 633\u2013645. https:\/\/doi.org\/10.1111\/PCN.13724","DOI":"10.1111\/PCN.13724"},{"issue":"5","key":"5940_CR184","doi-asserted-by":"publisher","first-page":"545","DOI":"10.3390\/PHARMACEUTICS18050545","volume":"18","author":"M Kaya","year":"2026","unstructured":"Kaya M, Akda\u015f\u00e7i E, Eker F, Bechelany M, Karav S (2026) Silver nanoparticles and neurotoxicity: mechanistic insights and recent experimental evidence. Pharm 18(5):545. https:\/\/doi.org\/10.3390\/PHARMACEUTICS18050545","journal-title":"Pharm"},{"key":"5940_CR185","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEULET.2018.06.033","volume":"726","author":"J Kealy","year":"2020","unstructured":"Kealy J, Greene C, Campbell M (2020) Blood-brain barrier regulation in psychiatric disorders. Neurosci Lett 726. https:\/\/doi.org\/10.1016\/J.NEULET.2018.06.033","journal-title":"Neurosci Lett"},{"issue":"4","key":"5940_CR186","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1007\/S13346-020-00891-5","volume":"12","author":"LA Keller","year":"2022","unstructured":"Keller LA, Merkel O, Popp A (2022) Intranasal drug delivery: opportunities and toxicologic challenges during drug development. Drug Deliv Transl Res 12(4):735\u2013757. https:\/\/doi.org\/10.1007\/S13346-020-00891-5","journal-title":"Drug Deliv Transl Res"},{"key":"5940_CR187","doi-asserted-by":"publisher","unstructured":"Khadrawy YA, Hosny EN, Magdy M, Mohammed HS (2021) Antidepressant effects of curcumin-coated iron oxide nanoparticles in a rat model of depression. Eur J Pharmacol 908:174384.\u00a0https:\/\/doi.org\/10.1016\/j.ejphar.2021.174384","DOI":"10.1016\/j.ejphar.2021.174384"},{"key":"5940_CR188","doi-asserted-by":"publisher","unstructured":"Khan S, Sharma A, Jain V (2023) An overview of nanostructured lipid carriers and its application in drug delivery through different routes. Adv Pharm Bull 13(3):446\u2013460. https:\/\/doi.org\/10.34172\/APB.2023.056","DOI":"10.34172\/APB.2023.056"},{"key":"5940_CR189","doi-asserted-by":"publisher","unstructured":"Khan N, Ruchika, Dhritlahre RK, Saneja A (2022)\u200f Recent advances in dual-ligand targeted nanocarriers for cancer therapy\u200f. Drug Discov Today 27(8):2288\u20132299\u200f. https:\/\/doi.org\/10.1016\/j.drudis.2022.04.011","DOI":"10.1016\/j.drudis.2022.04.011"},{"key":"5940_CR190","doi-asserted-by":"publisher","unstructured":"Khute S, Jangde\u200f RK (2023) Optimization of nasal liposome formulation of venlafaxine hydrochloride using a Box-Behnken experimental design\u200f. Curr Ther Res Exp 99:100714. https:\/\/doi.org\/10.1016\/j.curtheres.2023.100714","DOI":"10.1016\/j.curtheres.2023.100714"},{"key":"5940_CR191","doi-asserted-by":"publisher","first-page":"119385","DOI":"10.1016\/J.BIOPHA.2026.119385","volume":"199","author":"S Kim","year":"2026","unstructured":"Kim S, Park C, Lee Y, Lee K, Lee H, Lee K (2026) Inflammatory and immune-mediated toxicity of lipid nanoparticles. Biomed Pharmacother 199:119385. https:\/\/doi.org\/10.1016\/J.BIOPHA.2026.119385","journal-title":"Biomed Pharmacother"},{"key":"5940_CR192","doi-asserted-by":"publisher","first-page":"1463976","DOI":"10.3389\/FMED.2024.1463976","volume":"11","author":"A Kisku","year":"2024","unstructured":"Kisku A, Nishad A, Agrawal S, Paliwal R, Datusalia AK, Gupta G, Singh SK, Dua K, Sulakhiya K (2024) Recent developments in intranasal drug delivery of nanomedicines for the treatment of neuropsychiatric disorders. Front Med 11:1463976. https:\/\/doi.org\/10.3389\/FMED.2024.1463976","journal-title":"Front Med"},{"issue":"5","key":"5940_CR193","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1080\/14737175.2024.2334847","volume":"24","author":"Q Kong","year":"2024","unstructured":"Kong Q, Han B (2024) Pharmacotherapy and cognitive bias modification for the treatment of anxiety disorders. Expert Rev Neurother 24(5):517\u2013525. https:\/\/doi.org\/10.1080\/14737175.2024.2334847","journal-title":"Expert Rev Neurother"},{"key":"5940_CR194","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.2147\/IJN.S439181","volume":"19","author":"J Koo","year":"2024","unstructured":"Koo J, Lim C, Oh KT (2024) Recent advances in intranasal administration for brain-targeting delivery: a comprehensive review of lipid-based nanoparticles and stimuli-responsive gel formulations. Int J Nanomedicine 19:1767\u20131807. https:\/\/doi.org\/10.2147\/IJN.S439181","journal-title":"Int J Nanomedicine"},{"issue":"1","key":"5940_CR195","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1080\/19585969.2025.2463443","volume":"27","author":"T Korchia","year":"2025","unstructured":"Korchia T, Faug\u00e8re M, Achour V, Maakaron E, Andrieu-Haller C, Fond G, Lan\u00e7on C (2025) Impact of perceived side-effects of psychotropic treatments on quality of life in patients with severe mental illness. Dialogues Clin Neurosci 27(1):10\u201319. https:\/\/doi.org\/10.1080\/19585969.2025.2463443","journal-title":"Dialogues Clin Neurosci"},{"key":"5940_CR196","doi-asserted-by":"publisher","unstructured":"Kristensen M, Brodin B (2017) Routes for drug translocation across the blood-brain barrier: exploiting peptides as delivery vectors.\u00a0J Pharm Sci\u00a0106(9):2326-2334.\u00a0https:\/\/doi.org\/10.1016\/j.xphs.2017.04.080","DOI":"10.1016\/j.xphs.2017.04.080"},{"issue":"84","key":"5940_CR197","doi-asserted-by":"publisher","first-page":"68743","DOI":"10.1039\/c0xx00000x","volume":"5","author":"S Kumar","year":"2015","unstructured":"Kumar S, Randhawa JK (2015) Solid lipid nanoparticles of stearic acid for the drug delivery of paliperidone. RSC Adv 5(84):68743\u201368750. https:\/\/doi.org\/10.1039\/c0xx00000x","journal-title":"RSC Adv"},{"key":"5940_CR198","doi-asserted-by":"publisher","unstructured":"Kumar S, Randhawa JK (2013) Preparation and characterization of paliperidone loaded solid lipid nanoparticles. Colloids Surf B Biointerfaces 102:562\u2013568.\u00a0https:\/\/doi.org\/10.1016\/j.colsurfb.2012.08.052","DOI":"10.1016\/j.colsurfb.2012.08.052"},{"issue":"7","key":"5940_CR199","doi-asserted-by":"publisher","first-page":"3602","DOI":"10.1021\/ACS.MOLPHARMACEUT.5C00386","volume":"22","author":"S Kumar","year":"2025","unstructured":"Kumar S, Yadav A, Verma RK, Kumar A, Gupta PK, Shukla R (2025) Intranasal therapeutics for neurodegenerative disorders: overcoming the blood\u2013brain barrier with smart formulations and devices\u200f. ACS Publications\u200f, Molecular Pharmaceutics 22(7):3602\u20133620. https:\/\/doi.org\/10.1021\/ACS.MOLPHARMACEUT.5C00386","journal-title":"ACS Publications\u200f, Molecular Pharmaceutics"},{"issue":"3","key":"5940_CR200","doi-asserted-by":"publisher","first-page":"268","DOI":"10.2174\/1389201024666230523114350","volume":"25","author":"P Kumar","year":"2024","unstructured":"Kumar P, Yadav N, Chaudhary B, Umakanthan S, Chattu VK, Kazmi I, \u2026 Gupta MM (2024) Lipid nanocapsule: a novel approach to drug delivery system formulation development. Curr Pharm Biotechnol 25(3):268\u2013284. https:\/\/doi.org\/10.2174\/1389201024666230523114350","journal-title":"Curr Pharm Biotechnol"},{"key":"5940_CR201","doi-asserted-by":"publisher","unstructured":"Kumbhar SA, Kokare CR, Shrivastava B, Gorain B, Choudhury H (2021) Antipsychotic potential and safety profile of TPGS-based mucoadhesive aripiprazole nanoemulsion: development and optimization for nose-to-brain deliver. J Pharm Sci 110(4):1761\u20131778.\u00a0https:\/\/doi.org\/10.1016\/j.xphs.2021.01.021","DOI":"10.1016\/j.xphs.2021.01.021"},{"key":"5940_CR202","doi-asserted-by":"publisher","first-page":"113851","DOI":"10.1016\/j.addr.2021.113851","volume":"176","author":"DE Large","year":"2021","unstructured":"Large DE, Abdelmessih RG, Fink EA, Auguste DT (2021) Liposome composition in drug delivery design, synthesis, characterization, and clinical application. Adv Drug Deliv Rev 176:113851. https:\/\/doi.org\/10.1016\/j.addr.2021.113851","journal-title":"Adv Drug Deliv Rev"},{"issue":"10118","key":"5940_CR203","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/S0140-6736(17)32812-X","volume":"391","author":"JD Lee","year":"2018","unstructured":"Lee JD, Nunes EV, Novo P, Bachrach K, Bailey GL, Bhatt S, Farkas S, Fishman M, Gauthier P, Hodgkins CC, King J, Lindblad R, Liu D, Matthews AG, May J, Peavy KM, Ross S, Salazar D, Schkolnik P, Rotrosen J (2018) Comparative effectiveness of extended-release naltrexone versus buprenorphine-naloxone for opioid relapse prevention (X:BOT): a multicentre, open-label, randomised controlled trial. The Lancet 391(10118):309\u2013318. https:\/\/doi.org\/10.1016\/S0140-6736(17)32812-X","journal-title":"The Lancet"},{"key":"5940_CR204","doi-asserted-by":"publisher","first-page":"115049","DOI":"10.1016\/j.addr.2023.115049","volume":"201","author":"A L\u00e9rida-Viso","year":"2023","unstructured":"L\u00e9rida-Viso A, Estepa-Fern\u00e1ndez A, Garc\u00eda-Fern\u00e1ndez A, Mart\u00ed-Centelles V, Mart\u00ednez-M\u00e1\u00f1ez R (2023) Biosafety of mesoporous silica nanoparticles; towards clinical translation. Adv Drug Deliv Rev 201:115049. https:\/\/doi.org\/10.1016\/j.addr.2023.115049","journal-title":"Adv Drug Deliv Rev"},{"issue":"9657","key":"5940_CR205","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0140-6736(08)61764-X","volume":"373","author":"S Leucht","year":"2009","unstructured":"Leucht S, Corves C, Arbter D, Engel RR, Li C, Davis JM (2009) Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. Lancet 373(9657):31\u201341. https:\/\/doi.org\/10.1016\/S0140-6736(08)61764-X","journal-title":"Lancet"},{"issue":"10","key":"5940_CR206","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1176\/APPI.AJP.20240738;REQUESTEDJOURNAL:JOURNAL:AJP;WGROUP:STRING:PUBLICATION","volume":"181","author":"S Leucht","year":"2024","unstructured":"Leucht S, Priller J, Davis JM (2024) Antipsychotic drugs: a concise review of history, classification, indications, mechanism, efficacy, side effects, dosing, and clinical application. Am J Psychiatry 181(10):865\u2013878. https:\/\/doi.org\/10.1176\/APPI.AJP.20240738;REQUESTEDJOURNAL:JOURNAL:AJP;WGROUP:STRING:PUBLICATION","journal-title":"Am J Psychiatry"},{"key":"5940_CR207","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/J.SAJB.2023.12.029","volume":"165","author":"R Li","year":"2024","unstructured":"Li R, Chen X, Ye H, Sheng X (2024) Green synthesis of gold nanoparticles from the extract of Crocus sativus to study the effect of antidepressant in adolescence and to observe its aggressive and impulsive behavior in rat models. S Afr J Bot 165:455\u2013465. https:\/\/doi.org\/10.1016\/J.SAJB.2023.12.029","journal-title":"S Afr J Bot"},{"issue":"2","key":"5940_CR208","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3390\/PHARMACEUTICS16020223","volume":"16","author":"S Liga","year":"2024","unstructured":"Liga S, Paul C, Moac\u0103 EA, P\u00e9ter F (2024) Niosomes: composition, formulation techniques, and recent progress as delivery systems in cancer therapy. Pharm 16(2):223. https:\/\/doi.org\/10.3390\/PHARMACEUTICS16020223","journal-title":"Pharm"},{"key":"5940_CR209","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/J.YMETH.2021.07.009","volume":"199","author":"AL Lima","year":"2022","unstructured":"Lima AL, Gratieri T, Cunha-Filho M, Gelfuso GM (2022) Polymeric nanocapsules: a review on design and production methods for pharmaceutical purpose. Methods 199:54\u201366. https:\/\/doi.org\/10.1016\/J.YMETH.2021.07.009","journal-title":"Methods"},{"key":"5940_CR210","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/J.ACTBIO.2023.09.038","volume":"171","author":"L Liu","year":"2023","unstructured":"Liu L, Liu M, Xiu J, Zhang B, Hu H, Qiao M, Chen D, Zhang J, Zhao X (2023) Stimuli-responsive nanoparticles delivered by a nasal-brain pathway alleviate depression-like behavior through extensively scavenging ROS. Acta Biomater 171:451\u2013465. https:\/\/doi.org\/10.1016\/J.ACTBIO.2023.09.038","journal-title":"Acta Biomater"},{"key":"5940_CR211","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.134385","volume":"277","author":"A Lofts","year":"2024","unstructured":"Lofts A, Campea MA, Winterhelt E, Rigg N, Rivera NP, Macdonald C, \u2026 Hoare T (2024) In situ-gelling hydrophobized starch nanoparticle-based nanoparticle network hydrogels for the effective delivery of intranasal olanzapine to treat brain disorders. Int J Biol Macromol 277:134385. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.134385","journal-title":"Int J Biol Macromol"},{"key":"5940_CR212","doi-asserted-by":"publisher","unstructured":"Lofts A, Abu-Hijleh F, Rigg N, Winterhelt E, Kostashuk M , Monterio A, Tavakolian M (2025) Nose-to-brain delivery of lithium via a sprayable in situ-forming hydrogel composed of chelating starch nanoparticles\u200f. J Control Release 378:831\u2013846\u200f. https:\/\/doi.org\/10.1016\/j.jconrel.2024.12.063","DOI":"10.1016\/j.jconrel.2024.12.063"},{"issue":"3","key":"5940_CR213","doi-asserted-by":"publisher","first-page":"543","DOI":"10.3390\/PHARMACEUTICS14030543","volume":"14","author":"D Lombardo","year":"2022","unstructured":"Lombardo D, Kiselev MA (2022) Methods of liposomes preparation: formation and control factors of versatile nanocarriers for biomedical and nanomedicine application. Pharm 14(3):543. https:\/\/doi.org\/10.3390\/PHARMACEUTICS14030543","journal-title":"Pharm"},{"issue":"5","key":"5940_CR214","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.3390\/PHARMACEUTICS15051554","volume":"15","author":"R Lombardo","year":"2023","unstructured":"Lombardo R, Ruponen M, Rautio J, Ghelardini C, Di Cesare Mannelli L, Calosi L, Bani D, Lampinen R, Kanninen KM, Koivisto AM, Penttil\u00e4 E, L\u00f6pp\u00f6nen H, Pignatello R (2023) Development of lyophilised Eudragit\u00ae retard nanoparticles for the sustained release of clozapine via intranasal administration. Pharm 15(5):1554. https:\/\/doi.org\/10.3390\/PHARMACEUTICS15051554","journal-title":"Pharm"},{"issue":"9","key":"5940_CR215","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.3390\/PHARMACEUTICS17091104","volume":"17","author":"AKP Lorenzett","year":"2025","unstructured":"Lorenzett AKP, de Lima VA, da Fonseca COP, Mainardes RM (2025) Nanoemulsions and microemulsions for intranasal drug delivery: a bibliometric analysis and emerging trends (2004\u20132024). Pharm 17(9):1104. https:\/\/doi.org\/10.3390\/PHARMACEUTICS17091104","journal-title":"Pharm"},{"issue":"1","key":"5940_CR216","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/S12951-020-00709-Z","volume":"18","author":"L Lugasi","year":"2020","unstructured":"Lugasi L, Grinberg I, Rudnick-Glick S, Okun E, Einat H, Margel S (2020) Designed proteinoid polymers and nanoparticles encapsulating risperidone for enhanced antipsychotic activity. J Nanobiotechnology 18(1):149. https:\/\/doi.org\/10.1186\/S12951-020-00709-Z","journal-title":"J Nanobiotechnology"},{"key":"5940_CR217","doi-asserted-by":"publisher","unstructured":"\u0141ukasiewicz S, Szczepanowicz K, Podgorna K, B\u0142asiak E, Majeed N, Ogren SO\u00d6, \u2026 Dziedzicka-Wasylewska M (2016) Encapsulation of clozapinein polymeric nanocapsules and its biological effects. Colloids Surf B: Biointerfaces 140:342\u2013352.\u00a0https:\/\/doi.org\/10.1016\/j.colsurfb.2015.12.044","DOI":"10.1016\/j.colsurfb.2015.12.044"},{"key":"5940_CR218","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2147\/IJN.S566276","volume":"21","author":"K \u0141ukowiak","year":"2026","unstructured":"\u0141ukowiak K, Stolarczyk EU (2026) Green synthesis of zinc oxide nanoparticles and their application in anticancer drug delivery\u2013a review. Int J Nanomedicine 21:1\u201324. https:\/\/doi.org\/10.2147\/IJN.S566276","journal-title":"Int J Nanomedicine"},{"key":"5940_CR219","doi-asserted-by":"publisher","first-page":"1456939","DOI":"10.3389\/FNANO.2024.1456939\/FULL","volume":"6","author":"PD Ly","year":"2024","unstructured":"Ly PD, Ly KN, Phan HL, Nguyen HHT, Duong VA, Nguyen HV (2024) Recent advances in surface decoration of nanoparticles in drug delivery. Front Nanotechnol 6:1456939. https:\/\/doi.org\/10.3389\/FNANO.2024.1456939\/FULL","journal-title":"Front Nanotechnol"},{"key":"5940_CR220","doi-asserted-by":"publisher","unstructured":"Magro RD, Ornaghi F, Cambianica I, Beretta S, Re F, Musicanti C, Rigolio R, Donzelli\u200f E (2017\u200f) ApoE-modified solid lipid nanoparticles: a feasible strategy to cross the blood-brain barrier\u200f. J Control Release 249:103\u2013110. https:\/\/doi.org\/10.1016\/j.jconrel.2017.01.039","DOI":"10.1016\/j.jconrel.2017.01.039"},{"issue":"8","key":"5940_CR221","doi-asserted-by":"publisher","first-page":"4337","DOI":"10.1021\/ACS.MOLPHARMACEUT.5C00056","volume":"22","author":"R Maheshwari","year":"2025","unstructured":"Maheshwari R, Kapoor D, Polaka S, Bhattacharya S, Prajapati B (2025) Roadmap for commercial nanomedicine development: integrating quality by design principles with pharmaceutical nanotechnology. Mol Pharm 22(8):4337\u20134372. https:\/\/doi.org\/10.1021\/ACS.MOLPHARMACEUT.5C00056","journal-title":"Mol Pharm"},{"key":"5940_CR222","doi-asserted-by":"publisher","DOI":"10.1016\/J.NANTOD.2024.102314","author":"MM Mahmud","year":"2024","unstructured":"Mahmud MM, Pandey N, Winkles JA, Woodworth GF, Kim AJ (2024) Toward the scale-up production of polymeric nanotherapeutics for cancer clinical trials. Nano Today. https:\/\/doi.org\/10.1016\/J.NANTOD.2024.102314","journal-title":"Nano Today"},{"issue":"14","key":"5940_CR223","doi-asserted-by":"publisher","first-page":"3159","DOI":"10.3390\/MOLECULES25143159","volume":"25","author":"N Malhotra","year":"2020","unstructured":"Malhotra N, Lee JS, Liman RAD, Ruallo JMS, Villaflore OB, Ger TR, Hsiao CD (2020) Potential toxicity of iron oxide magnetic nanoparticles: a review. Molecules 25(14):3159. https:\/\/doi.org\/10.3390\/MOLECULES25143159","journal-title":"Molecules"},{"key":"5940_CR224","doi-asserted-by":"publisher","DOI":"10.3390\/NANO12173066","author":"AK Mandal","year":"2022","unstructured":"Mandal AK, Katuwal S, Tettey F, Gupta A, Bhattarai S, Jaisi S, Bhandari DP, Shah AK, Bhattarai N, Parajuli N (2022) Current research on zinc oxide nanoparticles: synthesis, characterization, and biomedical applications. Nanomaterials (Basel). https:\/\/doi.org\/10.3390\/NANO12173066","journal-title":"Nanomaterials (Basel)"},{"issue":"15","key":"5940_CR225","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1080\/17435889.2025.2533107","volume":"20","author":"B Mangla","year":"2025","unstructured":"Mangla B, Kumar P, Javed S, Pathan T, Ahsan W, Aggarwal G (2025) Regulating nanomedicines: challenges, opportunities, and the path forward. Nanomedicine (Lond) 20(15):1911\u20131927. https:\/\/doi.org\/10.1080\/17435889.2025.2533107","journal-title":"Nanomedicine (Lond)"},{"issue":"1","key":"5940_CR226","doi-asserted-by":"publisher","DOI":"10.1186\/S12916-024-03814-0","volume":"23","author":"MA Manter","year":"2025","unstructured":"Manter MA, Birtwell KB, Bath J, Friedman NDB, Keary CJ, Neumeyer AM, Palumbo ML, Thom RP, Stonestreet E, Brooks H, Dakin K, Hooker JM, McDougle CJ (2025) Pharmacological treatment in autism: a proposal for guidelines on common co-occurring psychiatric symptoms. BMC Med 23(1). https:\/\/doi.org\/10.1186\/S12916-024-03814-0","journal-title":"BMC Med"},{"issue":"8","key":"5940_CR227","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1007\/s00127-023-02425-z","volume":"58","author":"Mar J, Larra\u00f1aga I, Ibarrondo O, Gonz\u00e1lez-Pinto A, las Hayas C, Fullaondo A, Izco-Basurko I, Alonso J, Zorrilla I, Vilagut G, Mateo-Abad M, de Manuel E, on behalf of the UPRIGHT Consortium","year":"2023","unstructured":"Mar J, Larra\u00f1aga I, Ibarrondo O, Gonz\u00e1lez-Pinto A, las Hayas C, Fullaondo A, Izco-Basurko I, Alonso J, Zorrilla I, Vilagut G, Mateo-Abad M, de Manuel E, on behalf of the UPRIGHT Consortium (2023) Incidence of mental disorders in the general population aged 1\u201330 years disaggregated by gender and socioeconomic status. Soc Psychiatry Psychiatr Epidemiol 58(8):961\u2013971. https:\/\/doi.org\/10.1007\/s00127-023-02425-z","journal-title":"Soc Psychiatry Psychiatr Epidemiol"},{"issue":"1","key":"5940_CR228","doi-asserted-by":"publisher","first-page":"2366049","DOI":"10.1080\/20008066.2024.2366049","volume":"15","author":"M Marchi","year":"2024","unstructured":"Marchi M, Grenzi P, Boks MP (2024) Clonidine for post-traumatic stress disorder: a systematic review of the current evidence. Eur J Psychotraumatol 15(1):2366049. https:\/\/doi.org\/10.1080\/20008066.2024.2366049","journal-title":"Eur J Psychotraumatol"},{"key":"5940_CR229","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008940","author":"KS Marshall","year":"2011","unstructured":"Marshall KS, Gowing L, Ali R (2011) Pharmacotherapies for cannabis withdrawal. Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.CD008940","journal-title":"Cochrane Database Syst Rev"},{"issue":"9","key":"5940_CR230","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/S2215-0366(23)00193-1","volume":"10","author":"JJ McGrath","year":"2023","unstructured":"McGrath JJ, Al-Hamzawi A, Alonso J, Altwaijri Y, Andrade LH, Bromet EJ, Bruffaerts R, Caldas de Almeida JM, Chardoul S, Chiu WT, Degenhardt L, Demler OV, Ferry F, Gureje O, Haro JM, Karam EG, Karam G, Khaled SM, Kovess-Masfety V, Zaslavsky AM (2023) Age of onset and cumulative risk of mental disorders: a cross-national analysis of population surveys from 29 countries. The Lancet. Psychiatry 10(9):668\u2013681. https:\/\/doi.org\/10.1016\/S2215-0366(23)00193-1","journal-title":"The Lancet. Psychiatry"},{"key":"5940_CR231","doi-asserted-by":"publisher","unstructured":"Mehandole A, Walke N, Mahajan S, Aalhate M, Maji I, Gupta U, Mehra NK, Singh PK (2023) Core\u2013shell type lipidic and polymeric nanocapsules: the transformative multifaceted delivery systems\u200f. AAPS PharmSciTech 24(1):50.\u200f https:\/\/doi.org\/10.1208\/S12249-023-02504-Z","DOI":"10.1208\/S12249-023-02504-Z"},{"key":"5940_CR232","doi-asserted-by":"publisher","first-page":"111253","DOI":"10.1016\/j.pnpbp.2025.111253","volume":"136","author":"TP Mendes","year":"2025","unstructured":"Mendes TP, Pereira BG, Coutinho ESF, Melani MS, Neylan TC, Berger W (2025) Factors impacting prazosin efficacy for nightmares and insomnia in PTSD patients - a systematic review and meta-regression analysis. Prog Neuro-Psychopharmacol Biol Psychiatry 136:111253. https:\/\/doi.org\/10.1016\/j.pnpbp.2025.111253","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"issue":"1","key":"5940_CR233","doi-asserted-by":"publisher","first-page":"8","DOI":"10.4103\/INDIANJPSYCHIATRY_1186_25","volume":"68","author":"V Menon","year":"2026","unstructured":"Menon V, Ganesh R, Deep R, Sarkhel S, Goswami S, Mohapatra D, Munoli RN, Sharma PSVN, Reddy M, Muralidharan K (2026) Clinical practice guidelines for the management of bipolar disorder: 2025 update. Indian J Psychiatry 68(1):8. https:\/\/doi.org\/10.4103\/INDIANJPSYCHIATRY_1186_25","journal-title":"Indian J Psychiatry"},{"key":"5940_CR234","doi-asserted-by":"publisher","unstructured":"Meola TR, Dening TJ, Prestidge CA (2018) Nanocrystal-silica-lipid hybrid particles for the improved oral delivery of ziprasidone in vitro.\u00a0Eur J Pharm Biopharm\u00a0129:145\u2013153.\u00a0https:\/\/doi.org\/10.1016\/j.ejpb.2018.05.028","DOI":"10.1016\/j.ejpb.2018.05.028"},{"key":"5940_CR235","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD014965","author":"N Meza","year":"2022","unstructured":"Meza N, Rees R, Escobar Liquitay CM, Franco JVA, Sguassero Y, Williams K, Pringsheim T, Rojas V, Madrid E (2022) Atypical antipsychotics for autism spectrum disorder: a network meta-analysis. Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.CD014965","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"5940_CR236","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1002\/WPS.21225","volume":"23","author":"G Michelini","year":"2024","unstructured":"Michelini G, Carlisi CO, Eaton NR, Elison JT, Haltigan JD, Kotov R, Krueger RF, Latzman RD, Li JJ, Levin-Aspenson HF, Salum GA, South SC, Stanton K, Waldman ID, Wilson S (2024) Where do neurodevelopmental conditions fit in transdiagnostic psychiatric frameworks? Incorporating a new neurodevelopmental spectrum. World Psychiatry\u202f: Official Journal of the World Psychiatric Association (WPA) 23(3):333\u2013357. https:\/\/doi.org\/10.1002\/WPS.21225","journal-title":"World Psychiatry : Official Journal of the World Psychiatric Association (WPA)"},{"key":"5940_CR237","doi-asserted-by":"publisher","DOI":"10.3390\/COLLOIDS7010023","author":"SK Misra","year":"2023","unstructured":"Misra SK, Pathak K (2023) Nose-to-brain targeting via nanoemulsion: significance and evidence. Colloids and Interfaces. https:\/\/doi.org\/10.3390\/COLLOIDS7010023","journal-title":"Colloids and Interfaces"},{"issue":"1","key":"5940_CR238","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/S11671-024-04132-3","volume":"19","author":"P Mittal","year":"2024","unstructured":"Mittal P, Singla M, Smriti kapoor R, Kumar D, Gupta S, Gupta G, Bhattacharya T (2024) Paclitaxel loaded Capmul MCM and tristearin based nanostructured lipid carriers (NLCs) for glioblastoma treatment: screening of formulation components by quality by design (QbD) approach. Discov Nano 19(1):175. https:\/\/doi.org\/10.1186\/S11671-024-04132-3","journal-title":"Discov Nano"},{"issue":"1","key":"5940_CR239","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1186\/S12879-025-11503-3","volume":"25","author":"MS Mohamed","year":"2025","unstructured":"Mohamed MS, Zary M, Kafie C, Chilala CI, Bahukudumbi S, Foster N, Gore G, Fielding K, Subbaraman R, Schwartzman K (2025) The impact of digital adherence technologies on treatment outcomes, adherence, and patient-reported outcomes in tuberculosis: a systematic review and meta. BMC Infect Dis 25(1):1314. https:\/\/doi.org\/10.1186\/S12879-025-11503-3","journal-title":"BMC Infect Dis"},{"issue":"6","key":"5940_CR240","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/S00228-026-04085-9","volume":"82","author":"A Mohammad","year":"2026","unstructured":"Mohammad A, Ibrahim M, Khan AM, Pervaiz U, Aijaz S, Nasrullah MH, Jamil H (2026) Ondansetron augmentation for obsessive-compulsive disorder: A systematic review and meta-analysis of randomized placebo-controlled trials. Eur J Clin Pharmacol 82(6):157. https:\/\/doi.org\/10.1007\/S00228-026-04085-9","journal-title":"Eur J Clin Pharmacol"},{"issue":"1","key":"5940_CR241","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1080\/03639045.2020.1862172","volume":"47","author":"P Mohammadi","year":"2021","unstructured":"Mohammadi P, Mahjub R, Mohammadi M, Derakhshandeh K, Ghaleiha A, Mahboobian MM (2021) Pharmacokinetics and brain distribution studies of perphenazine-loaded solid lipid nanoparticles. Drug Dev Ind Pharm 47(1):146\u2013152. https:\/\/doi.org\/10.1080\/03639045.2020.1862172","journal-title":"Drug Dev Ind Pharm"},{"key":"5940_CR242","doi-asserted-by":"publisher","unstructured":"Mohammed AA, Abd Alhammid SN (2024) Preparation, in vitro evaluation and characterization studies of clozapine nanosuspension. Iraqi J Pharm Sci 33((4SI)): 336\u2013348. https:\/\/doi.org\/10.31351\/VOL33ISS(4SI)PP336-348","DOI":"10.31351\/VOL33ISS(4SI)PP336-348"},{"issue":"7","key":"5940_CR243","doi-asserted-by":"publisher","DOI":"10.3390\/PHARMACEUTICS15071985","volume":"15","author":"D Mohanty","year":"2023","unstructured":"Mohanty D, Alsaidan OA, Zafar A, Dodle T, Gupta JK, Yasir M, Mohanty A, Khalid M (2023) Development of atomoxetine-loaded NLC in situ gel for nose-to-brain delivery: optimization, in vitro, and preclinical evaluation. Pharmaceutics 15(7). https:\/\/doi.org\/10.3390\/PHARMACEUTICS15071985","journal-title":"Pharmaceutics"},{"issue":"1","key":"5940_CR244","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1186\/S12951-024-02511-7","volume":"22","author":"R Moreira","year":"2024","unstructured":"Moreira R, N\u00f3brega C, de Almeida LP, Mendon\u00e7a L (2024) Brain-targeted drug delivery-nanovesicles directed to specific brain cells by brain-targeting ligands. J Nanobiotechnology 22(1):260. https:\/\/doi.org\/10.1186\/S12951-024-02511-7","journal-title":"J Nanobiotechnology"},{"key":"5940_CR245","doi-asserted-by":"publisher","unstructured":"Mourdikoudis S, Kostopoulou A, LaGrow AP (2021) Magnetic nanoparticle composites: synergistic effects and applications. Adv Sci (Weinheim, Baden-Wurttemberg, Germany) 8(12):2004951. https:\/\/doi.org\/10.1002\/ADVS.202004951","DOI":"10.1002\/ADVS.202004951"},{"key":"5940_CR246","doi-asserted-by":"publisher","unstructured":"Moya ELJ, Lombardo SM, Vandenhaute E, Schneider M, Mysiorek C, T\u00fcreli AE, Kanda T, Shimizu F,Sano Y, Maubon N, Gosselet F, G\u00fcnday-T\u00fcreli N, Dehouck MP (2022) Interaction of surfactant coated PLGA nanoparticles with in vitro human brain-like endothelial cells. \u200fInt J Pharm 621:121780. https:\/\/doi.org\/10.1016\/j.ijpharm.2022.121780","DOI":"10.1016\/j.ijpharm.2022.121780"},{"key":"5940_CR247","doi-asserted-by":"publisher","unstructured":"M\u00fclhopt S, Diabat\u00e9 S, Dilger M, Adelhelm C, Anderlohr C, Bergfeldt T, \u2026 Paur HR (2018) Characterization of nanoparticle batch-to-batch variability. Nanomaterials 8(5):311.\u00a0https:\/\/doi.org\/10.3390\/nano8050311","DOI":"10.3390\/nano8050311"},{"issue":"2","key":"5940_CR248","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1080\/08982104.2023.2268711","volume":"34","author":"M Munir","year":"2024","unstructured":"Munir M, Zaman M, Waqar MA, Khan MA, Alvi MN (2024) Solid lipid nanoparticles: a versatile approach for controlled release and targeted drug delivery. J Liposome Res 34(2):335\u2013348. https:\/\/doi.org\/10.1080\/08982104.2023.2268711","journal-title":"J Liposome Res"},{"issue":"1","key":"5940_CR249","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1080\/10717544.2022.2075985","volume":"29","author":"AA Musallam","year":"2022","unstructured":"Musallam AA, Mahdy MA, Elnahas HM, Aldeeb RA (2022) Optimization of mirtazapine loaded into mesoporous silica nanostructures via Box-Behnken design: in-vitro characterization and in-vivo assessment. Drug Deliv 29(1):1582\u20131594. https:\/\/doi.org\/10.1080\/10717544.2022.2075985","journal-title":"Drug Deliv"},{"issue":"22","key":"5940_CR250","doi-asserted-by":"publisher","first-page":"7988","DOI":"10.3390\/MOLECULES27227988","volume":"27","author":"P Nancy","year":"2022","unstructured":"Nancy P, Joy N, Valluvadasan S, Philip R, Thomas S, Antoine R, Kalarikkal N (2022) Fluorescence and nonlinear optical response of graphene quantum dots produced by pulsed laser irradiation in toluene. Mol 27(22):7988. https:\/\/doi.org\/10.3390\/MOLECULES27227988","journal-title":"Mol"},{"issue":"3","key":"5940_CR251","doi-asserted-by":"publisher","first-page":"976","DOI":"10.3390\/PHARMACEUTICS15030976","volume":"15","author":"I Negut","year":"2023","unstructured":"Negut I, Bita B (2023) Polymeric micellar systems-a special emphasis on \u201csmart\u201d drug delivery. Pharm 15(3):976. https:\/\/doi.org\/10.3390\/PHARMACEUTICS15030976","journal-title":"Pharm"},{"key":"5940_CR252","doi-asserted-by":"publisher","DOI":"10.1016\/J.CARPTA.2023.100332","volume":"6","author":"G Nerli","year":"2023","unstructured":"Nerli G, Robla S, Bartalesi M, Luceri C, D\u2019Ambrosio M, Csaba N, Maestrelli F (2023) Chitosan coated niosomes for nose-to-brain delivery of clonazepam: formulation, stability and permeability studies. Carbohydrate Polymer Technologies and Applications 6. https:\/\/doi.org\/10.1016\/J.CARPTA.2023.100332","journal-title":"Carbohydrate Polymer Technologies and Applications"},{"issue":"5","key":"5940_CR253","doi-asserted-by":"publisher","first-page":"615","DOI":"10.3390\/PH18050615","volume":"18","author":"TTL Nguyen","year":"2025","unstructured":"Nguyen TTL, Duong VA (2025) Advancements in nanocarrier systems for nose-to-brain drug delivery. Pharm 18(5):615. https:\/\/doi.org\/10.3390\/PH18050615","journal-title":"Pharm"},{"issue":"14","key":"5940_CR254","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1001\/JAMA.2023.18588","volume":"330","author":"AA Nierenberg","year":"2023","unstructured":"Nierenberg AA, Agustini B, K\u00f6hler-Forsberg O, Cusin C, Katz D, Sylvia LG, Peters A, Berk M (2023) Diagnosis and treatment of bipolar disorder: a review. JAMA 330(14):1370\u20131380. https:\/\/doi.org\/10.1001\/JAMA.2023.18588","journal-title":"JAMA"},{"key":"5940_CR255","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS25074057","author":"\u0141 Ni\u017cnik","year":"2024","unstructured":"Ni\u017cnik \u0141, Noga M, Kobylarz D, Frydrych A, Kro\u015bniak A, Kapka-Skrzypczak L, Jurowski K (2024) Gold nanoparticles (AuNPs)-toxicity, safety and green synthesis: a critical review. Int J Mol Sci. https:\/\/doi.org\/10.3390\/IJMS25074057","journal-title":"Int J Mol Sci"},{"issue":"5","key":"5940_CR256","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1007\/S43440-022-00412-W\/METRICS","volume":"74","author":"CH Nodari","year":"2022","unstructured":"Nodari CH, De Quadros ND, Chiarentin R, Da Silva FP, Morisso FDP, Char\u00e3o MF, Fleck JD, De Mattos CB, Betti AH, Verza SG (2022) Vortioxetine liposomes as a novel alternative to improve drug stability under stress conditions: toxicity studies and evaluation of antidepressant-like effect. Pharmacol Rep 74(5):969\u2013981. https:\/\/doi.org\/10.1007\/S43440-022-00412-W\/METRICS","journal-title":"Pharmacol Rep"},{"issue":"6","key":"5940_CR257","doi-asserted-by":"publisher","first-page":"5133","DOI":"10.3390\/IJMS24065133","volume":"24","author":"M Noga","year":"2023","unstructured":"Noga M, Milan J, Frydrych A, Jurowski K (2023) Toxicological aspects, safety assessment, and green toxicology of silver nanoparticles (AgNPs)-critical review: state of the art. Int J Mol Sci 24(6):5133. https:\/\/doi.org\/10.3390\/IJMS24065133","journal-title":"Int J Mol Sci"},{"issue":"4","key":"5940_CR258","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.psc.2024.04.012","volume":"47","author":"KB O\u2019Leary","year":"2024","unstructured":"O\u2019Leary KB, Khan JS (2024) Pharmacotherapy for anxiety disorders. Psychiatr Clin North Am 47(4):689\u2013709. https:\/\/doi.org\/10.1016\/j.psc.2024.04.012","journal-title":"Psychiatr Clin North Am"},{"issue":"1","key":"5940_CR259","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/S11671-023-03898-2","volume":"18","author":"JE Ogbezode","year":"2023","unstructured":"Ogbezode JE, Ezealigo US, Bello A, Anye VC, Onwualu AP (2023) A narrative review of the synthesis, characterization, and applications of iron oxide nanoparticles. Discov Nano 18(1):125. https:\/\/doi.org\/10.1186\/S11671-023-03898-2","journal-title":"Discov Nano"},{"key":"5940_CR260","doi-asserted-by":"publisher","DOI":"10.1016\/J.ECLINM.2025.103413","volume":"87","author":"V Oliva","year":"2025","unstructured":"Oliva V, De Prisco M, La Spina E, Paolucci S, Fico G, Anmella G, Hidalgo-Mazzei D, Murru A, Pompili M, Fornaro M, Solmi M, Yildiz A, Leucht S, Vieta E, Radua J (2025) Switch to mania after acute antidepressant treatment for bipolar depression: a systematic review and network meta-analysis of randomised controlled trials. EClinicalMedicine 87. https:\/\/doi.org\/10.1016\/J.ECLINM.2025.103413","journal-title":"EClinicalMedicine"},{"key":"5940_CR261","doi-asserted-by":"crossref","unstructured":"Opris R, Toma V, Baciu A, Moldovan R, Dume B, Berghian-Sevastre A, Moldovan B\u200f, Clichici S, David L, Filip GA, Florea A (2021) Neurobehavioral and ultrastructural changes induced by phytosynthesized silver-nanoparticle toxicity in an in vivo rat model\u200f. Nanomater 12(1):58. https:\/\/doi.org\/10.3390\/nano12010058","DOI":"10.3390\/nano12010058"},{"issue":"7","key":"5940_CR262","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1080\/10837450.2022.2124521","volume":"27","author":"H Ouyang","year":"2022","unstructured":"Ouyang H, Hu J, Qiu XY, Wu S, Guo F, Tan Y (2022) Improved biopharmaceutical performance of antipsychotic drug using lipid nanoparticles via intraperitoneal route. Pharm Dev Technol 27(7):853\u2013863. https:\/\/doi.org\/10.1080\/10837450.2022.2124521","journal-title":"Pharm Dev Technol"},{"key":"5940_CR263","doi-asserted-by":"publisher","unstructured":"\u00d6zg\u00fcven HD, Kir Y (2021) Long acting injectable antipsychotics in the treatment of schizophrenia and bipolar disorder. Arch Neuropsychiatry 58(Suppl 1): S47. https:\/\/doi.org\/10.29399\/NPA.27480","DOI":"10.29399\/NPA.27480"},{"issue":"29","key":"5940_CR264","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1080\/17435889.2024.2405458","volume":"19","author":"RM Pallares","year":"2024","unstructured":"Pallares RM, Kiessling F, Lammers T (2024) Clinical translation of quantum dots. Nanomedicine (Lond) 19(29):2433\u20132435. https:\/\/doi.org\/10.1080\/17435889.2024.2405458","journal-title":"Nanomedicine (Lond)"},{"issue":"2","key":"5940_CR265","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/27\/2\/025102","volume":"27","author":"YR Pandey","year":"2015","unstructured":"Pandey YR, Kumar S, Gupta BK, Ali J, Baboota S (2015) Intranasal delivery of paroxetine nanoemulsion via the olfactory region for the management of depression: formulation, behavioural and biochemical estimation. Nanotechnology 27(2). https:\/\/doi.org\/10.1088\/0957-4484\/27\/2\/025102","journal-title":"Nanotechnology"},{"key":"5940_CR266","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2174\/0118715273445992260410072951","volume":"25","author":"A Pannu","year":"2026","unstructured":"Pannu A, Agarwal U (2026) Future of preclinical depression research: a perspective of behavioral models with validity and translational potential description. CNS & Neurological Disorders - Drug Targets 25:1\u201333. https:\/\/doi.org\/10.2174\/0118715273445992260410072951","journal-title":"CNS & Neurological Disorders - Drug Targets"},{"issue":"5","key":"5940_CR267","doi-asserted-by":"publisher","first-page":"878","DOI":"10.3390\/CANCERS17050878","volume":"17","author":"A Pareek","year":"2025","unstructured":"Pareek A, Kumar D, Pareek A, Gupta MM (2025) Advancing cancer therapy with quantum dots and other nanostructures: a review of drug delivery innovations, applications, and challenges. Cancers 17(5):878. https:\/\/doi.org\/10.3390\/CANCERS17050878","journal-title":"Cancers"},{"issue":"6","key":"5940_CR268","doi-asserted-by":"publisher","first-page":"468","DOI":"10.3109\/1061186X.2010.523787","volume":"19","author":"S Patel","year":"2011","unstructured":"Patel S, Chavhan S, Soni H, Babbar AK, Mathur R, Mishra AK, Sawant K (2011) Brain targeting of risperidone-loaded solid lipid nanoparticles by intranasal route. J Drug Target 19(6):468\u201374. https:\/\/doi.org\/10.3109\/1061186X.2010.523787","journal-title":"J Drug Target"},{"key":"5940_CR269","doi-asserted-by":"publisher","first-page":"120474","DOI":"10.1016\/j.ijpharm.2021.120474","volume":"600","author":"HP Patel","year":"2021","unstructured":"Patel HP, Chaudhari PS, Gandhi PA, Desai BV, Desai DT, Dedhiya PP, Vyas BA, Maulvi FA (2021) Nose to brain delivery of tailored clozapine nanosuspension stabilized using (+)-alpha-tocopherol polyethylene glycol 1000 succinate: optimization and in vivo pharmacokinetic studies. Int J Pharm 600:120474. https:\/\/doi.org\/10.1016\/j.ijpharm.2021.120474","journal-title":"Int J Pharm"},{"issue":"2","key":"5940_CR270","doi-asserted-by":"publisher","first-page":"155","DOI":"10.2174\/0124681873270830231101205139","volume":"14","author":"AD Patel","year":"2023","unstructured":"Patel AD, Modi CD, Thakkar VT, Rana HB, Chavda DD (2023) Development and characterization of lipid nanoparticles loaded with antipsychotic drugs using central composite design. Current Nanomedicine (Formerly: Recent Patents on Nanomedicine) 14(2):155\u2013168. https:\/\/doi.org\/10.2174\/0124681873270830231101205139","journal-title":"Current Nanomedicine (Formerly: Recent Patents on Nanomedicine)"},{"issue":"43","key":"5940_CR271","doi-asserted-by":"publisher","first-page":"2401990","DOI":"10.1002\/SMLL.202401990;CTYPE:STRING:JOURNAL","volume":"20","author":"D Patel","year":"2024","unstructured":"Patel D, Solanki J, Kher MM, Azagury A (2024) A review: surface engineering of lipid-based drug delivery systems. Small 20(43):2401990. https:\/\/doi.org\/10.1002\/SMLL.202401990;CTYPE:STRING:JOURNAL","journal-title":"Small"},{"key":"5940_CR272","doi-asserted-by":"publisher","unstructured":"Patel M, Minglani VV, Vaddadi H, Jha LL, Patel LD, Huanbutta K, Sangnim T (2025a) Advancements in nanotherapeutics for the treatment of depression via intranasal pathway: a review. Int J Nanomedicine 20:7323\u20137342.https:\/\/doi.org\/10.2147\/IJN.S525759","DOI":"10.2147\/IJN.S525759"},{"key":"5940_CR273","doi-asserted-by":"publisher","DOI":"10.3390\/NANO15231766","author":"T Patel","year":"2025","unstructured":"Patel T, Clipstone C, Girija UV, Ahmad Z, Singh N (2025b) Nanotoxicity of porous silica nanoparticles: physicochemical properties and mechanistic cellular endpoints. Nanomaterials (Basel). https:\/\/doi.org\/10.3390\/NANO15231766","journal-title":"Nanomaterials (Basel)"},{"issue":"10","key":"5940_CR274","doi-asserted-by":"publisher","first-page":"635","DOI":"10.4155\/TDE-2023-0059","volume":"14","author":"VS Patil","year":"2023","unstructured":"Patil VS, Sutar KP, Pockle RD, Usulkar S, Jadhav VA (2023) Formulation, optimization and evaluation of amisulpride-loaded niosomal intranasal gel for brain targeting. Ther Deliv 14(10):635\u2013647. https:\/\/doi.org\/10.4155\/TDE-2023-0059","journal-title":"Ther Deliv"},{"key":"5940_CR275","doi-asserted-by":"publisher","unstructured":"Patil A, Rajput A, Subbappa P, Pawar A (2025) Formulation, development and in vivo characterization of selegiline hydrochloride nanostructured lipid nanocarrier loaded microneedle array patch for depression. Int J Pharm 671:125257.\u00a0https:\/\/doi.org\/10.1016\/j.ijpharm.2025.125257","DOI":"10.1016\/j.ijpharm.2025.125257"},{"issue":"5","key":"5940_CR276","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(24)00053-7","volume":"9","author":"V Patwardhan","year":"2024","unstructured":"Patwardhan V, Gil GF, Arrieta A, Cagney J, DeGraw E, Herbert ME, Khalil M, Mullany EC, O\u2019Connell EM, Spencer CN, Stein C, Valikhanova A, Gakidou E, Flor LS (2024) Differences across the lifespan between females and males in the top 20 causes of disease burden globally: a systematic analysis of the Global Burden of Disease Study 2021. Lancet Public Health 9(5). https:\/\/doi.org\/10.1016\/S2468-2667(24)00053-7","journal-title":"Lancet Public Health"},{"key":"5940_CR277","doi-asserted-by":"publisher","DOI":"10.1021\/ACSCHEMNEURO.2C00673","author":"SD Pawar","year":"2023","unstructured":"Pawar SD, Gawali K, Kulhari H, Murty US, Kumar P (2023) Amoxapine-loaded solid lipid nanoparticles with superior preclinical pharmacokinetics for better brain delivery: LC-MS\/MS and GC-MS analysis. ACS Chem Neurosci. https:\/\/doi.org\/10.1021\/ACSCHEMNEURO.2C00673","journal-title":"ACS Chem Neurosci"},{"issue":"3","key":"5940_CR278","doi-asserted-by":"publisher","DOI":"10.7759\/CUREUS.80725","volume":"17","author":"DA Pereira","year":"2025","unstructured":"Pereira DA, Cheidde L, Megiolaro MDR, Camargo AEF, Weba ETP, Soares VG, Silva A, Cheidde L, J\u00fanior PPL, Amaral DC, Triaca R, Fernandes MAN, Mimura PMP (2025) Efficacy and safety of cannabinoids for autism spectrum disorder: an updated systematic review. Cureus 17(3). https:\/\/doi.org\/10.7759\/CUREUS.80725","journal-title":"Cureus"},{"issue":"12","key":"5940_CR279","doi-asserted-by":"publisher","first-page":"2510","DOI":"10.3390\/POLYM14122510","volume":"14","author":"S Perumal","year":"2022","unstructured":"Perumal S, Atchudan R, Lee W (2022) A review of polymeric micelles and their applications. Polymers 14(12):2510. https:\/\/doi.org\/10.3390\/POLYM14122510","journal-title":"Polymers"},{"issue":"4","key":"5940_CR280","doi-asserted-by":"publisher","first-page":"2024065787","DOI":"10.1542\/PEDS.2024-065787\/196922","volume":"153","author":"BS Peterson","year":"2024","unstructured":"Peterson BS, Trampush J, Maglione M, Bolshakova M, Rozelle M, Miles J, Pakdaman S, Brown M, Yagyu S, Motala A, Hempel S (2024) Treatments for ADHD in children and adolescents: a systematic review. Pediatrics 153(4):2024065787. https:\/\/doi.org\/10.1542\/PEDS.2024-065787\/196922","journal-title":"Pediatrics"},{"key":"5940_CR281","doi-asserted-by":"publisher","unstructured":"Piazza J, Hoare T, Molinaro L, Terpstra K, Bhandari J, Selvaganapathy PR, Gupta B, Mishra RK (2014)\u200f Haloperidol-loaded intranasally administered lectin functionalized poly (ethylene glycol)\u2013block-poly (d, l)-lactic-co-glycolic acid (PEG\u2013PLGA) nanoparticles for the treatment of schizophrenia. Eur JPharm Biopharm 87(1):30\u201339\u200f. https:\/\/doi.org\/10.1016\/j.ejpb.2014.02.007","DOI":"10.1016\/j.ejpb.2014.02.007"},{"key":"5940_CR282","doi-asserted-by":"publisher","first-page":"119361","DOI":"10.1016\/j.ijpharm.2020.119361","volume":"583","author":"V Piazzini","year":"2020","unstructured":"Piazzini V, Landucci E, Urru M, Chiarugi A, Pellegrini-Giampietro DE, Bilia AR, Bergonzi MC (2020) Enhanced dissolution, permeation and oral bioavailability of aripiprazole mixed micelles: in vitro and in vivo evaluation. Int J Pharm 583:119361. https:\/\/doi.org\/10.1016\/j.ijpharm.2020.119361","journal-title":"Int J Pharm"},{"key":"5940_CR283","doi-asserted-by":"publisher","unstructured":"Pimpalshende PM, Gupta RN, Pankaj M, Pimpalshende M, Pharm M (2018) Formulation and in-vitro drug released mechanism of CNS acting venlafaxine nanostructured lipid carrier for major depressive disorder. \u200fIndian J Pharm Edu Res 52(2). https:\/\/doi.org\/10.5530\/ijper.52.2.26","DOI":"10.5530\/ijper.52.2.26"},{"key":"5940_CR284","doi-asserted-by":"publisher","unstructured":"P\u0131nar SG, Oktay AN, Karak\u00fc\u00e7\u00fck AE, \u00c7elebi N (2023) Formulation strategies of nanosuspensions for various administration routes. Pharmaceutics 15(5):1520.\u200f https:\/\/doi.org\/10.3390\/PHARMACEUTICS15051520","DOI":"10.3390\/PHARMACEUTICS15051520"},{"key":"5940_CR285","doi-asserted-by":"publisher","unstructured":"Pinioti E, Glarou E, Lappas AS, Fober I, Helfer B, Siafis S, Christodoulou N, Nikolakopoulou A, Leucht S, Samara M (2025) Examining the safety profile of clozapine versus other antipsychotics: systematic review and meta-analysis. Br J Psychiatry J Men Sci 1-10 https:\/\/doi.org\/10.1192\/BJP.2025.10421","DOI":"10.1192\/BJP.2025.10421"},{"key":"5940_CR286","doi-asserted-by":"publisher","unstructured":"Pinkiewicz M, Pinkiewicz M, Walecki J, Zaczy\u0144ski A, Zawadzki M (2024) Breaking barriers in neuro-oncology: a scoping literature review on invasive and non-invasive techniques for blood\u2013brain barrier disruption. Cancers 16(1):236.\u00a0https:\/\/doi.org\/10.3390\/cancers16010236","DOI":"10.3390\/cancers16010236"},{"issue":"7","key":"5940_CR287","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.3390\/PHARMACEUTICS15071878\/S1","volume":"15","author":"PC Pires","year":"2023","unstructured":"Pires PC, Fernandes M, Nina F, Gama F, Gomes MF, Rodrigues LE, Meirinho S, Silvestre S, Alves G, Santos AO (2023) Innovative aqueous nanoemulsion prepared by phase inversion emulsification with exceptional homogeneity. Pharmaceutics 15(7):1878. https:\/\/doi.org\/10.3390\/PHARMACEUTICS15071878\/S1","journal-title":"Pharmaceutics"},{"issue":"2","key":"5940_CR288","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/S40883-024-00373-X","volume":"11","author":"H Pirojiya","year":"2025","unstructured":"Pirojiya H, Dudhat K (2025) Niosomes: a revolution in sustainable and targeted drug delivery-green synthesis, precision medicine, and beyond. Regen Eng Transl Med 11(2):379\u2013415. https:\/\/doi.org\/10.1007\/S40883-024-00373-X","journal-title":"Regen Eng Transl Med"},{"key":"5940_CR289","doi-asserted-by":"publisher","unstructured":"PJ JR, Oluwafemi O, Thomas S, Oyedeji AO (2022) Recent advances in drug delivery nanocarriers incorporated in temperature-sensitive Pluronic F-127\u2013A critical review\u200f. J Drug Deliv Sci Technol. https:\/\/doi.org\/10.1016\/j.jddst.2022.103390","DOI":"10.1016\/j.jddst.2022.103390"},{"issue":"26","key":"5940_CR290","doi-asserted-by":"publisher","first-page":"17685","DOI":"10.1039\/D3RA02883F","volume":"13","author":"DR Pokhrel","year":"2023","unstructured":"Pokhrel DR, Sah MK, Gautam B, Basak HK, Bhattarai A, Chatterjee A (2023) A recent overview of surfactant-drug interactions and their importance. RSC Adv 13(26):17685\u201317704. https:\/\/doi.org\/10.1039\/D3RA02883F","journal-title":"RSC Adv"},{"issue":"5","key":"5940_CR291","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1080\/17425247.2026.2628612","volume":"23","author":"NN Porfiryeva","year":"2026","unstructured":"Porfiryeva NN, Moustafine RI, Khutoryanskiy VV (2026) Advances in mucoadhesive and mucus-penetrating materials, nano-formulations, and in situ gelling systems for nasal drug delivery. Expert Opin Drug Deliv 23(5):797\u2013822. https:\/\/doi.org\/10.1080\/17425247.2026.2628612","journal-title":"Expert Opin Drug Deliv"},{"key":"5940_CR292","doi-asserted-by":"publisher","unstructured":"Prajapati JB, Verma SD, Patel AA (2018) Oral bioavailability enhancement of agomelatine by loading into nanostructured lipid carriers: Peyer\u2019s patch targeting approach. \u200fInt J Nanomedicine 13(T-NANO 2014 Abstracts):35-38. https:\/\/doi.org\/10.2147\/IJN.S124703","DOI":"10.2147\/IJN.S124703"},{"issue":"1","key":"5940_CR293","doi-asserted-by":"publisher","first-page":"6640103","DOI":"10.1155\/2023\/6640103","volume":"2023","author":"Sambhakar S Preeti","year":"2023","unstructured":"Preeti Sambhakar S, Malik R, Bhatia S, Al Harrasi A, Rani C, Saharan R, Kumar S, Geeta & Sehrawat R (2023) Nanoemulsion: an emerging novel technology for improving the bioavailability of drugs. Scientifica 2023(1):6640103. https:\/\/doi.org\/10.1155\/2023\/6640103","journal-title":"Scientifica"},{"key":"5940_CR294","doi-asserted-by":"publisher","DOI":"10.1016\/J.ADDR.2023.114822","volume":"197","author":"R Qiao","year":"2023","unstructured":"Qiao R, Fu C, Forgham H, Javed I, Huang X, Zhu J, Whittaker AK, Davis TP (2023) Magnetic iron oxide nanoparticles for brain imaging and drug delivery. Adv Drug Deliv Rev 197. https:\/\/doi.org\/10.1016\/J.ADDR.2023.114822","journal-title":"Adv Drug Deliv Rev"},{"issue":"6","key":"5940_CR295","doi-asserted-by":"publisher","first-page":"e70213","DOI":"10.1002\/MCO2.70213","volume":"6","author":"Y Qiu","year":"2025","unstructured":"Qiu Y, Huang S, Peng L, Yang L, Zhang G, Liu T, Yan F, Peng X (2025) The Nasal\u2013brain drug delivery route: mechanisms and applications to central nervous system diseases. MedComm 6(6):e70213. https:\/\/doi.org\/10.1002\/MCO2.70213","journal-title":"MedComm"},{"key":"5940_CR296","doi-asserted-by":"publisher","unstructured":"Qizilbash FF, Ashhar MU, Zafar A, Qamar Z, Annu, Ali J, Baboota S, Ghoneim MM, Alshehri S, Ali A (2022) Thymoquinone-enriched naringenin-loaded nanostructured lipid carrier for brain delivery via nasal route: In vitro prospect and in vivo therapeutic efficacy for the treatment of depression. Pharm 14(3):656. https:\/\/doi.org\/10.1016\/j.jconrel.2020.09.042","DOI":"10.1016\/j.jconrel.2020.09.042"},{"key":"5940_CR297","doi-asserted-by":"publisher","unstructured":"Rabanel JM, Piec PA, Landri S, Patten SA, Ramassamy C (2020) Transport of PEGylated-PLA nanoparticles across a blood brain barrier model, entry into neuronal cells and in vivo brain bioavailability. J Control Release 328:679\u2013695.\u00a0https:\/\/doi.org\/10.1016\/j.jconrel.2020.09.042\u00a0","DOI":"10.1016\/j.jconrel.2020.09.042"},{"key":"5940_CR298","doi-asserted-by":"publisher","unstructured":"Radnik J, Hodoroaba V, Jungnickel H, Tentschert J, Luch A, Sogne V, Meier F, Burr L, Schmid D, Schlager C, Yoon TH, Peters R, Briffa SM, Valsami-Jones E (2022) Automation and standardization\u2014a coupled approach towards reproducible sample preparation protocols for nanomaterial analysis.\u00a0Molecules\u00a027(3):985. https:\/\/doi.org\/10.3390\/molecules27030985","DOI":"10.3390\/molecules27030985"},{"key":"5940_CR299","doi-asserted-by":"publisher","unstructured":"Rajadurai U, Prabha L, Hariharan A, Antony J, Achiraman, Nandagopalan V (2019) Anxiolytic and anti-depressant effects of AgNPs fabricated using diosgenin. https:\/\/doi.org\/10.2139\/ssrn.3370113","DOI":"10.2139\/ssrn.3370113"},{"issue":"07","key":"5940_CR300","doi-asserted-by":"publisher","first-page":"171","DOI":"10.7324\/JAPS.2016.60725","volume":"6","author":"R Rajput","year":"2016","unstructured":"Rajput R, Kumar S, Nag P, Singh M (2016) Fabrication and characterization of chitosan based polymeric escitalopram nanoparticles. J Appl Pharm Sci 6(07):171\u2013177. https:\/\/doi.org\/10.7324\/JAPS.2016.60725","journal-title":"J Appl Pharm Sci"},{"issue":"2","key":"5940_CR301","doi-asserted-by":"publisher","first-page":"279","DOI":"10.3390\/PHARMACEUTICS14020279","volume":"14","author":"MJ Ramalho","year":"2022","unstructured":"Ramalho MJ, Loureiro JA, Coelho MAN, Pereira MC (2022) Transferrin receptor-targeted nanocarriers: overcoming barriers to treat glioblastoma. Pharm 14(2):279. https:\/\/doi.org\/10.3390\/PHARMACEUTICS14020279","journal-title":"Pharm"},{"key":"5940_CR302","doi-asserted-by":"publisher","unstructured":"Rana I, Khan N, Ansari MM, Shah FA, Din F, ud, Sarwar S, Imran M, Qureshi OS, Choi HI, Lee CH, Kim JK, Zeb A (2020) Solid lipid nanoparticles-mediated enhanced antidepressant activity of duloxetine in lipopolysaccharide-induced depressive model. Colloids Surf B: Biointerfaces 194:111209. https:\/\/doi.org\/10.1016\/J.COLSURFB.2020.111209","DOI":"10.1016\/J.COLSURFB.2020.111209"},{"issue":"11","key":"5940_CR303","doi-asserted-by":"publisher","first-page":"965","DOI":"10.2217\/NNM-2023-0229","volume":"19","author":"H Rao","year":"2024","unstructured":"Rao H, Rao I, Ahmad S, Madni A, Ahmad I (2024) Compritol\u00ae-based solid lipid nanoparticles of desvenlafaxine prepared by ultrasonication-assisted hot-melt encapsulation to modify its release. Nanomedicine 19(11):965\u2013978. https:\/\/doi.org\/10.2217\/NNM-2023-0229","journal-title":"Nanomedicine"},{"issue":"2","key":"5940_CR304","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/WPS.21190;JOURNAL:JOURNAL:20515545;WGROUP:STRING:PUBLICATION","volume":"23","author":"GM Reed","year":"2024","unstructured":"Reed GM (2024) What\u2019s in a name? Mental disorders, mental health conditions and psychosocial disability. World Psychiatry 23(2):209\u2013210. https:\/\/doi.org\/10.1002\/WPS.21190;JOURNAL:JOURNAL:20515545;WGROUP:STRING:PUBLICATION","journal-title":"World Psychiatry"},{"issue":"3","key":"5940_CR305","doi-asserted-by":"publisher","first-page":"217","DOI":"10.2174\/2468187313666221020143555","volume":"12","author":"AS Rekharani","year":"2022","unstructured":"Rekharani AS, Nidamanuri BSS, Rajendra PKM, Venkatachalam S, Selvaraj J, Natarajan J (2022) Formulation, optimization and characterization of bupropion hydrochloride loaded nanostructured lipid carriers for intra-nasal administration: an approach to management of smoking cessation. Current Nanomedicine 12(3):217\u2013232. https:\/\/doi.org\/10.2174\/2468187313666221020143555","journal-title":"Current Nanomedicine"},{"issue":"7","key":"5940_CR306","doi-asserted-by":"publisher","first-page":"3563","DOI":"10.1021\/ACS.MOLPHARMACEUT.5C00297","volume":"22","author":"S Rezaee","year":"2025","unstructured":"Rezaee S, Al-Majdoub ZM, Galetin A, Rostami-Hodjegan A, Ogungbenro K (2025) Challenges and opportunities for incorporating physiological information into pharmacokinetic models of intranasal drug delivery to the brain: a review of the current status and future trajectories. Mol Pharm 22(7):3563\u20133577. https:\/\/doi.org\/10.1021\/ACS.MOLPHARMACEUT.5C00297","journal-title":"Mol Pharm"},{"issue":"4","key":"5940_CR307","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1097\/YIC.0000000000000559","volume":"40","author":"V Ricci","year":"2025","unstructured":"Ricci V, Sarni A, Martinotti G, Maina G (2025) Comparative analysis of third-generation antipsychotics in first-episode schizophrenia: efficacy, safety, and cognitive impacts. A narrative review. Int Clin Psychopharmacol 40(4):191\u2013206. https:\/\/doi.org\/10.1097\/YIC.0000000000000559","journal-title":"Int Clin Psychopharmacol"},{"key":"5940_CR308","doi-asserted-by":"publisher","DOI":"10.5772\/INTECHOPEN.103906","author":"S Roch\u00edn-Wong","year":"2022","unstructured":"Roch\u00edn-Wong S, Rivas IV, Roch\u00edn-Wong S, Rivas IV (2022) Lipid and polymeric nanocapsules. Drug Carrier. https:\/\/doi.org\/10.5772\/INTECHOPEN.103906","journal-title":"Drug Carrier"},{"key":"5940_CR309","doi-asserted-by":"publisher","unstructured":"Rodas JD, George TP, Hassan AN (2024) A systematic review of the clinical effects of cannabis and cannabinoids in posttraumatic stress disorder symptoms and symptom clusters. J Clin Psychiatry 85(1):23r14862. https:\/\/doi.org\/10.4088\/JCP.23R14862","DOI":"10.4088\/JCP.23R14862"},{"key":"5940_CR310","doi-asserted-by":"publisher","first-page":"1544393","DOI":"10.3389\/FMED.2025.1544393\/FULL","volume":"12","author":"FD Rodr\u00edguez-G\u00f3mez","year":"2025","unstructured":"Rodr\u00edguez-G\u00f3mez FD, Monferrer D, Penon O, Rivera-Gil P (2025) Regulatory pathways and guidelines for nanotechnology-enabled health products: a comparative review of EU and US frameworks. Front Med 12:1544393. https:\/\/doi.org\/10.3389\/FMED.2025.1544393\/FULL","journal-title":"Front Med"},{"issue":"12","key":"5940_CR311","doi-asserted-by":"publisher","first-page":"3438","DOI":"10.1007\/S13346-024-01559-0","volume":"14","author":"B Rossier","year":"2024","unstructured":"Rossier B, Jordan O, All\u00e9mann E, Rodr\u00edguez-Nogales C (2024) Nanocrystals and nanosuspensions: an exploration from classic formulations to advanced drug delivery systems. Drug Deliv Transl Res 14(12):3438\u20133451. https:\/\/doi.org\/10.1007\/S13346-024-01559-0","journal-title":"Drug Deliv Transl Res"},{"issue":"17","key":"5940_CR312","doi-asserted-by":"publisher","first-page":"25046","DOI":"10.1021\/ACSOMEGA.5C09893","volume":"11","author":"M Roudn\u00fd","year":"2026","unstructured":"Roudn\u00fd M, Balouch M, Hanu\u0161 J, \u0160t\u011bp\u00e1nek F (2026) Direct experimental comparison of liposome formulation processes for poorly permeable solutes: effect of driving force and bilayer disruption mechanism. ACS Omega 11(17):25046\u201325056. https:\/\/doi.org\/10.1021\/ACSOMEGA.5C09893","journal-title":"ACS Omega"},{"key":"5940_CR313","doi-asserted-by":"publisher","unstructured":"Ruan S, Zhou Y, Jiang X, Gao H (2021) Rethinking CRITID procedure of brain targeting drug delivery: circulation, blood brain barrier recognition, intracellular transport, diseased cell targeting, internalization, and drug release. Adv Sci (Weinheim, Baden-Wurttemberg, Germany) 8(9):2004025. https:\/\/doi.org\/10.1002\/ADVS.202004025","DOI":"10.1002\/ADVS.202004025"},{"key":"5940_CR314","doi-asserted-by":"publisher","first-page":"120670","DOI":"10.1016\/J.IJPHARM.2021.120670","volume":"603","author":"S Rubab","year":"2021","unstructured":"Rubab S, Naeem K, Rana I, Khan N, Afridi M, Ullah I, Shah FA, Sarwar S, Din F, ud, Choi HI, Lee CH, Lim CW, Alamro AA, Kim JK, Zeb A (2021) Enhanced neuroprotective and antidepressant activity of curcumin-loaded nanostructured lipid carriers in lipopolysaccharide-induced depression and anxiety rat model. Int J Pharm 603:120670. https:\/\/doi.org\/10.1016\/J.IJPHARM.2021.120670","journal-title":"Int J Pharm"},{"key":"5940_CR315","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.102813","author":"M Saeedi","year":"2021","unstructured":"Saeedi M, Morteza-Semnani K, Akbari J, Siahposht-Khachaki A, Firouzi M, Goodarzi A, Abootorabi S, Babaei A, Hashemi SMH, Nokhodchi A (2021) Brain targeting of venlafaxine HCl as a hydrophilic agent prepared through green lipid nanotechnology. J Drug Deliv Sci Technol. https:\/\/doi.org\/10.1016\/j.jddst.2021.102813","journal-title":"J Drug Deliv Sci Technol"},{"key":"5940_CR316","doi-asserted-by":"publisher","unstructured":"Saeidienik F, Shahraki MR, Fanaei H, Badini F (2018) The effects of iron oxide nanoparticles administration on depression symptoms induced by LPS in male Wistar rats.\u00a0Basic Clin Neurosci\u00a09(3):209. https:\/\/doi.org\/10.29252\/NIRP.BCN.9.3.209","DOI":"10.29252\/NIRP.BCN.9.3.209"},{"key":"5940_CR317","doi-asserted-by":"publisher","first-page":"121906","DOI":"10.1016\/J.MOLLIQ.2023.121906","volume":"382","author":"U Saha","year":"2023","unstructured":"Saha U, De R, Das B (2023) Interactions between loaded drugs and surfactant molecules in micellar drug delivery systems: a critical review. J Mol Liq 382:121906. https:\/\/doi.org\/10.1016\/J.MOLLIQ.2023.121906","journal-title":"J Mol Liq"},{"key":"5940_CR318","doi-asserted-by":"publisher","unstructured":"Salawi A, Almoshari Y, Sultan MH, Madkhali OA, Bakkari MA, Alshamrani M, Safhi AY, Sabei FY, Al Hagbani T, Ali MS, Alam MS (2023) Production, characterization, and in vitro and in vivo studies of nanoemulsions containing St. John\u2019s wort plant constituents and their potential for the treatment of depression. Pharm 16(4): 490. https:\/\/doi.org\/10.3390\/PH16040490\/S1","DOI":"10.3390\/PH16040490\/S1"},{"key":"5940_CR319","doi-asserted-by":"publisher","DOI":"10.1016\/J.CARTRE.2024.100407","volume":"17","author":"A Salvi","year":"2024","unstructured":"Salvi A, Kharbanda S, Thakur P, Shandilya M, Thakur A (2024) Biomedical application of carbon quantum dots: a review. Carbon Trends 17. https:\/\/doi.org\/10.1016\/J.CARTRE.2024.100407","journal-title":"Carbon Trends"},{"key":"5940_CR320","unstructured":"Sambhakar SHARDA, Paliwal SK, Sharma S, Sati BHAWANA, Singh B (2017)\u00a0Formulation and development of risperidone loaded niosomes for improved bioavailability: in vitro and in vivo study.\u00a0Acta Pol Pharm\u2013Drug Res\u00a074:1859\u20131873"},{"issue":"12","key":"5940_CR321","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.3390\/polym17121640","volume":"17","author":"M Santhamoorthy","year":"2025","unstructured":"Santhamoorthy M, Asaithambi P, Ramkumar V, Elangovan N, Perumal I, Kim SC (2025) A review on the recent advancements of polymer-modified mesoporous silica nanoparticles for drug delivery under stimuli-trigger. Polymers 17(12):1640. https:\/\/doi.org\/10.3390\/polym17121640","journal-title":"Polymers"},{"issue":"4","key":"5940_CR322","doi-asserted-by":"publisher","first-page":"e59074","DOI":"10.7759\/CUREUS.59074","volume":"16","author":"NS Santi","year":"2024","unstructured":"Santi NS, Biswal SB, Naik BN, Sahoo JP, Rath B (2024) A randomized controlled trial comparing efficacy and safety of antidepressant monotherapy. Cureus 16(4):e59074. https:\/\/doi.org\/10.7759\/CUREUS.59074","journal-title":"Cureus"},{"key":"5940_CR323","doi-asserted-by":"publisher","unstructured":"Santomauro DF, Miller PA, Shadid J, Hanson SW, Vo A, Roy DJ, Hagins H et al (2026) Updated trends in the global prevalence and burden of mental disorders, 1990\u20132023: a systematic analysis for the Global Burden of Disease Study 2023. The Lancet 407(10543):2040\u20132064.\u00a0https:\/\/doi.org\/10.1016\/S0140-6736(26)00519-2","DOI":"10.1016\/S0140-6736(26)00519-2"},{"issue":"8","key":"5940_CR324","doi-asserted-by":"publisher","DOI":"10.3390\/PHARMACEUTICS13081183","volume":"13","author":"MK Satapathy","year":"2021","unstructured":"Satapathy MK, Yen TL, Jan JS, Tang RD, Wang JY, Taliyan R, Yang CH (2021) Solid lipid nanoparticles (SLNs): an advanced drug delivery system targeting brain through BBB. Pharmaceutics 13(8). https:\/\/doi.org\/10.3390\/PHARMACEUTICS13081183","journal-title":"Pharmaceutics"},{"issue":"8","key":"5940_CR325","doi-asserted-by":"publisher","first-page":"7549","DOI":"10.1021\/ACSOMEGA.4C11045","volume":"10","author":"A Sati","year":"2025","unstructured":"Sati A, Ranade TN, Mali SN, Ahmad Yasin HK, Pratap A (2025) Silver nanoparticles (AgNPs): comprehensive insights into bio\/synthesis, key influencing factors, multifaceted applications, and toxicity a 2024 update. ACS Omega 10(8):7549\u20137582. https:\/\/doi.org\/10.1021\/ACSOMEGA.4C11045","journal-title":"ACS Omega"},{"key":"5940_CR326","doi-asserted-by":"publisher","unstructured":"Sawant K, Pandey A, Patel S (2016) Aripiprazole loaded poly (caprolactone) nanoparticles: optimization and in vivo pharmacokinetics. Mater Sci Eng C Mater Biol Appl 66:230\u2013243.\u00a0https:\/\/doi.org\/10.1016\/j.msec.2016.04.089","DOI":"10.1016\/j.msec.2016.04.089"},{"issue":"3","key":"5940_CR327","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3238\/arztebl.m2021.0017","volume":"118","author":"TE Schl\u00e4pfer","year":"2021","unstructured":"Schl\u00e4pfer TE, Meyer-Lindenberg A, Synofzik M, Visser-Vandewalle V, Voges J, Coenen VA (2021) Invasive brain stimulation in the treatment of psychiatric illness: proposed indications and approaches. Deutsch \u00c4rztebl Int 118(3):31. https:\/\/doi.org\/10.3238\/arztebl.m2021.0017","journal-title":"Deutsch \u00c4rztebl Int"},{"issue":"4","key":"5940_CR328","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/S2215-0366(25)00001-X","volume":"12","author":"J Schneider-Thoma","year":"2025","unstructured":"Schneider-Thoma J, Hamza T, Chalkou K, Siafis S, Dong S, Bighelli I, Hansen WP, Scheuring E, Davis JM, Priller J, Baumann P, Conley R, Cordes J, Kelly D, Kluge M, Kumra S, Lewis S, Meltzer HY, Naber D, Schooler N, Volavka J, Wahlbeck K, Salanti G, Leucht S (2025) Efficacy of clozapine versus second-generation antipsychotics in people with treatment-resistant schizophrenia: a systematic review and individual patient data meta-analysis. Lancet Psychiatry 12(4):254\u2013265. https:\/\/doi.org\/10.1016\/S2215-0366(25)00001-X","journal-title":"Lancet Psychiatry"},{"issue":"32","key":"5940_CR329","doi-asserted-by":"publisher","first-page":"25910","DOI":"10.1039\/D5RA03578C","volume":"15","author":"D Senanayake","year":"2025","unstructured":"Senanayake D, Yapa P, Dabare S, Munaweera I (2025) Precision targeting of the CNS: recent progress in brain-directed nanodrug delivery. RSC Adv 15(32):25910\u201325928. https:\/\/doi.org\/10.1039\/D5RA03578C","journal-title":"RSC Adv"},{"issue":"8","key":"5940_CR330","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.3390\/PHARMACEUTICS16081047","volume":"16","author":"A Serras","year":"2024","unstructured":"Serras A, Faustino C, Pinheiro L (2024) Functionalized polymeric micelles for targeted cancer therapy: steps from conceptualization to clinical trials. Pharm 16(8):1047. https:\/\/doi.org\/10.3390\/PHARMACEUTICS16081047","journal-title":"Pharm"},{"key":"5940_CR331","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAD.2025.119586","volume":"388","author":"G Sesso","year":"2025","unstructured":"Sesso G, Fantozzi P, Calderoni S, Masi G (2025) Mood stabilizers in eating disorders: a systematic review. J Affect Disord 388. https:\/\/doi.org\/10.1016\/J.JAD.2025.119586","journal-title":"J Affect Disord"},{"issue":"02\/03","key":"5940_CR332","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1055\/A-2795-7008","volume":"76","author":"A Shadab","year":"2026","unstructured":"Shadab A, Ansari AF (2026) Translational insights into liposomal drug delivery: recent advances, therapeutic applications, and clinical trials. Drug Research 76(02\/03):65\u201381. https:\/\/doi.org\/10.1055\/A-2795-7008","journal-title":"Drug Research"},{"issue":"1","key":"5940_CR333","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/S12247-026-10876-5","volume":"22","author":"A Shadab","year":"2026","unstructured":"Shadab A, Haider MF, Abohassan M (2026a) Lipid nanoparticles based drug delivery systems: design innovations, therapeutic applications, and translational progress. J Pharm Innov 22(1):2. https:\/\/doi.org\/10.1007\/S12247-026-10876-5","journal-title":"J Pharm Innov"},{"issue":"4","key":"5940_CR334","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1208\/S12249-026-03425-3","volume":"27","author":"A Shadab","year":"2026","unstructured":"Shadab A, Haider MF, Abohassan M (2026b) Liposome-based drug delivery systems: mechanisms, preparation strategies, clinical status, and therapeutic applications. AAPS PharmSciTech 27(4):190. https:\/\/doi.org\/10.1208\/S12249-026-03425-3","journal-title":"AAPS PharmSciTech"},{"issue":"1","key":"5940_CR335","doi-asserted-by":"publisher","first-page":"4718","DOI":"10.1038\/S41598-022-08759-Z","volume":"12","author":"S Shahrad","year":"2022","unstructured":"Shahrad S, Rajabi M, Javadi H, Karimi Zarchi AA, Darvishi MH (2022) Targeting lung cancer cells with MUC1 aptamer-functionalized PLA-PEG nanocarriers. Sci Rep 12(1):4718. https:\/\/doi.org\/10.1038\/S41598-022-08759-Z","journal-title":"Sci Rep"},{"key":"5940_CR336","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.2147\/IJN.S345430","volume":"17","author":"RA Shalaby","year":"2022","unstructured":"Shalaby RA, El-Gazayerly O, Abdallah M (2022) Cubosomal betamethasone-salicylic acid nano drug delivery system for enhanced management of scalp psoriasis. Int J Nanomed 17:1659\u20131677. https:\/\/doi.org\/10.2147\/IJN.S345430","journal-title":"Int J Nanomed"},{"key":"5940_CR337","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/J.MATPR.2020.01.568","volume":"28","author":"S Sharma","year":"2020","unstructured":"Sharma S, Dang S (2020) Paroxetine loaded PLGA nanoparticles. Mater Today Proc 28:205\u2013210. https:\/\/doi.org\/10.1016\/J.MATPR.2020.01.568","journal-title":"Mater Today Proc"},{"key":"5940_CR338","doi-asserted-by":"publisher","unstructured":"Sharma D, Maheshwari D, Philip G, Rana R, Bhatia S, Singh M, Gabrani R, Sharma SK, Ali J, Sharma RK, Dang S (2014) Formulation and optimization of polymeric nanoparticles for intranasal delivery of lorazepam using Box\u2010Behnken design: in vitro and in vivo evaluation. BioMed Res Int. https:\/\/doi.org\/10.1155\/2014\/156010","DOI":"10.1155\/2014\/156010"},{"issue":"5","key":"5940_CR339","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1208\/S12249-015-0294-0","volume":"16","author":"D Sharma","year":"2015","unstructured":"Sharma D, Sharma RK, Sharma N, Gabrani R, Sharma SK, Ali J, Dang S (2015) Nose-to-brain delivery of PLGA-diazepam nanoparticles. AAPS Pharmscitech 16(5):1121\u20131108. https:\/\/doi.org\/10.1208\/S12249-015-0294-0","journal-title":"AAPS Pharmscitech"},{"key":"5940_CR340","doi-asserted-by":"publisher","unstructured":"Sharma S, Gauba P, Tyagi A, Dang S (2025) Chitosan-modified polymeric nanoparticles for the nose-to-brain drug delivery of paroxetine: an in vitro and in vivo evaluation. Nanoscale 17(3):1687\u20131702.\u00a0https:\/\/doi.org\/10.1039\/d4nr04250f","DOI":"10.1039\/d4nr04250f"},{"issue":"7","key":"5940_CR341","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1001\/JAMAINTERNMED.2026.0395","volume":"186","author":"RL Shepardson","year":"2026","unstructured":"Shepardson RL, Khan JS, Buckheit KA, Funderburk JS (2026) Treatment of anxiety for adults in primary care settings: a review. JAMA Intern Med 186(7):878\u2013889. https:\/\/doi.org\/10.1001\/JAMAINTERNMED.2026.0395","journal-title":"JAMA Intern Med"},{"issue":"6","key":"5940_CR342","doi-asserted-by":"publisher","first-page":"2658","DOI":"10.1208\/S12249-018-1079-Z\/FIGURES\/14","volume":"19","author":"MH Shukr","year":"2018","unstructured":"Shukr MH, Ahmed Farid OA (2018) Amisulpride\u2013CD-loaded liposomes: optimization and in vivo evaluation. AAPS PharmSciTech 19(6):2658\u20132671. https:\/\/doi.org\/10.1208\/S12249-018-1079-Z\/FIGURES\/14","journal-title":"AAPS PharmSciTech"},{"issue":"1","key":"5940_CR343","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/S40265-025-02261-2","volume":"86","author":"EK Silberman","year":"2025","unstructured":"Silberman EK (2025) Benefits and liabilities of benzodiazepines and Z-drugs: what we know and what we don\u2019t know. Drugs 86(1):1\u20139. https:\/\/doi.org\/10.1007\/S40265-025-02261-2","journal-title":"Drugs"},{"key":"5940_CR344","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROPHARM.2025.110441","volume":"273","author":"S Silva","year":"2025","unstructured":"Silva S, Bicker J, Falc\u00e3o A, Dallmann R, Fortuna A (2025) Chronopharmacokinetics of the antidepressant paroxetine: an in vitro and in vivo approach. Neuropharmacology 273. https:\/\/doi.org\/10.1016\/J.NEUROPHARM.2025.110441","journal-title":"Neuropharmacology"},{"key":"5940_CR345","doi-asserted-by":"publisher","unstructured":"Singh A, Kumar A (2022) Development and characterisation of methylphenidate hydrochloride loaded nanoparticles.\u00a0Int J Health Sci\u00a06(S1):7519\u20137534. https:\/\/doi.org\/10.53730\/ijhs.v6nS1.6724","DOI":"10.53730\/ijhs.v6nS1.6724"},{"issue":"6","key":"5940_CR346","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1007\/S13346-012-0110-2","volume":"2","author":"AP Singh","year":"2012","unstructured":"Singh AP, Saraf SK, Saraf SA (2012) SLN approach for nose-to-brain delivery of alprazolam. Drug Deliv Transl Res 2(6):498\u2013507. https:\/\/doi.org\/10.1007\/S13346-012-0110-2","journal-title":"Drug Deliv Transl Res"},{"key":"5940_CR347","doi-asserted-by":"publisher","DOI":"10.1039\/c5ra19793g","author":"SK Singh","year":"2016","unstructured":"Singh SK, Dadhania P, Rao Vuddanda P, Jain A, Velaga S, Singh S (2016) Intranasal delivery of asenapine loaded nanostructured lipid carriers: formulation, characterization, pharmacokinetic and behavioural assessment. RSC Adv. https:\/\/doi.org\/10.1039\/c5ra19793g","journal-title":"RSC Adv"},{"key":"5940_CR348","doi-asserted-by":"publisher","first-page":"177737","DOI":"10.1016\/j.ejphar.2025.177737","volume":"1001","author":"N Singh","year":"2025","unstructured":"Singh N, Hazari PP, Mittal P, Yadav SK, Kumar N, Mishra G, Dahiya S, Mishra AK (2025a) Role of selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors and psychedelics in the treatment of major depressive disorder: a perspective on mechanistic insight and current status. Eur J Pharmacol 1001:177737. https:\/\/doi.org\/10.1016\/j.ejphar.2025.177737","journal-title":"Eur J Pharmacol"},{"key":"5940_CR349","doi-asserted-by":"publisher","unstructured":"Singh S, Singh A, Chittu S, Sharma S (2025b) Precision nanomedicine for anxiety: challenges, opportunities, and future directions in targeted drug delivery. J Food Drug Anal 33(3):241\u2013251. https:\/\/doi.org\/10.38212\/2224-6614.3556","DOI":"10.38212\/2224-6614.3556"},{"key":"5940_CR350","doi-asserted-by":"publisher","unstructured":"Singh JP, Gaur V, Dubey P (2025c) Precision, prediction and progress: a new era in pharmacology\u200f.\u200f Int J Innovative Sci Res Technol (IJISRT) 10(04):888\u2013910. https:\/\/doi.org\/10.38124\/ijisrt\/25apr1322","DOI":"10.38124\/ijisrt\/25apr1322"},{"issue":"6","key":"5940_CR351","doi-asserted-by":"publisher","first-page":"644","DOI":"10.2174\/1567201818666210708123855\/CITE\/REFWORKS","volume":"19","author":"K Singhal","year":"2021","unstructured":"Singhal K, Kaushik N, Kumar A (2021) Cubosomes: versatile nanosized formulation for efficient delivery of therapeutics. Curr Drug Deliv 19(6):644\u2013657. https:\/\/doi.org\/10.2174\/1567201818666210708123855\/CITE\/REFWORKS","journal-title":"Curr Drug Deliv"},{"issue":"4","key":"5940_CR352","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.3390\/BIOMEDICINES11041114","volume":"11","author":"D Sivadasan","year":"2023","unstructured":"Sivadasan D, Sultan MH, Alqahtani SS, Javed S (2023) Cubosomes in drug delivery-a comprehensive review on its structural components, preparation techniques and therapeutic applications. Biomedicines 11(4):1114. https:\/\/doi.org\/10.3390\/BIOMEDICINES11041114","journal-title":"Biomedicines"},{"key":"5940_CR353","doi-asserted-by":"publisher","unstructured":"Song J, Lu C, Leszek J, Zhang J (2021) Design and development of nanomaterial-based drug carriers to overcome the blood\u2013brain barrier by using different transport mechanisms. Int J Mol Sci 22(18):10118.\u00a0https:\/\/doi.org\/10.3390\/ijms221810118","DOI":"10.3390\/ijms221810118"},{"key":"5940_CR354","doi-asserted-by":"publisher","first-page":"113858","DOI":"10.1016\/j.colsurfb.2024.113858","volume":"237","author":"N Soomherun","year":"2024","unstructured":"Soomherun N, Kreua-ongarjnukool N, Niyomthai ST, Chumnanvej S (2024) Lipid-polymer hybrid nanoparticles synthesized via lipid-based surface engineering for a robust drug delivery platform. Colloids Surf B: Biointerfaces 237:113858. https:\/\/doi.org\/10.1016\/j.colsurfb.2024.113858","journal-title":"Colloids Surf B: Biointerfaces"},{"issue":"1","key":"5940_CR355","doi-asserted-by":"publisher","first-page":"23631","DOI":"10.1038\/s41598-025-08807-4","volume":"15","author":"F Sourani","year":"2025","unstructured":"Sourani F, Najafzadehvarzi H, Ranaee M, Rahimi A (2025) Assessment of neurobehavioral and histopathological impacts of graphene quantum dots in NMRI mice. Sci Rep 15(1):23631. https:\/\/doi.org\/10.1038\/s41598-025-08807-4","journal-title":"Sci Rep"},{"key":"5940_CR356","doi-asserted-by":"publisher","unstructured":"Sukhanova A, Bozrova S, Guhrenz C, Gaponik N, Karaulov A, Nabiev I (2022) Dependence of quantum dot toxicity in vitro on their size, chemical composition, and surface charge. Nanomaterials 12(16):2734.\u00a0https:\/\/doi.org\/10.3390\/nano12162734","DOI":"10.3390\/nano12162734"},{"key":"5940_CR357","doi-asserted-by":"publisher","unstructured":"Tadayonnejad R, Corlier J, Valles TE, Citrenbaum C, Matthews C, Einstein E, Wilke SA, Slan A, Distler MG, Hoftman G, Adelekun AE, Oughli HA, Leuchter MK, Artin H, Koek RJ, Ginder ND, Krantz D, Strouse T, Leuchter AF (2024\u200f) Safety and efficacy of targeting the supplementary motor area with double-cone deep transcranial magnetic stimulation vs figure-eight coil in treatment of obsessive. \u200fJ Psychiatr Res 179:295\u2013299\u200f. https:\/\/doi.org\/10.1016\/j.jpsychires.2024.09.026","DOI":"10.1016\/j.jpsychires.2024.09.026"},{"issue":"6","key":"5940_CR358","doi-asserted-by":"publisher","first-page":"4547","DOI":"10.1007\/S12011-026-04980-3","volume":"204","author":"A Taheri","year":"2026","unstructured":"Taheri A, Alimohammadi S, Abdolmohammadi A (2026) Antidepressant-related signaling pathways of zinc oxide nanoparticles in a mouse model of postpartum depression. Biol Trace Elem Res 204(6):4547\u20134560. https:\/\/doi.org\/10.1007\/S12011-026-04980-3","journal-title":"Biol Trace Elem Res"},{"key":"5940_CR359","doi-asserted-by":"publisher","unstructured":"Tashan E, Karakucuk A, Celebi N (2019) Optimization and in vitro evaluation of ziprasidone nanosuspensions produced by a top-down approach. J Drug Deliv Sci Technol 52:37\u201345. https:\/\/doi.org\/10.1016\/J.JDDST.2019.04.024","DOI":"10.1016\/J.JDDST.2019.04.024"},{"key":"5940_CR360","doi-asserted-by":"publisher","unstructured":"Teaima M, El-Nadi MT, Hamed RR, El-Nabarawi MA, Abdelmonem R (2023) Lyophilized nasal inserts of atomoxetine HCl solid lipid nanoparticles for brain targeting as a treatment of attention-deficit\/hyperactivity disorder (ADHD): a pharmacokinetics study on rats. Pharmaceuticals (Basel) 16(2):326.\u00a0https:\/\/doi.org\/10.3390\/ph16020326","DOI":"10.3390\/ph16020326"},{"key":"5940_CR361","doi-asserted-by":"publisher","unstructured":"Teixeira MI, Lopes CM, Amaral MH, Costa PC (2024) Navigating neurotoxicity and safety assessment of nanocarriers for brain delivery: strategies and insights. Acta Biomater 189:25\u201356.\u00a0https:\/\/doi.org\/10.1016\/j.actbio.2024.09.027","DOI":"10.1016\/j.actbio.2024.09.027"},{"issue":"5","key":"5940_CR362","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/S41573-021-00139-Y","volume":"20","author":"GC Terstappen","year":"2021","unstructured":"Terstappen GC, Meyer AH, Bell RD, Zhang W (2021) Strategies for delivering therapeutics across the blood-brain barrier. Nat Rev Drug Discov 20(5):362\u2013383. https:\/\/doi.org\/10.1038\/S41573-021-00139-Y","journal-title":"Nat Rev Drug Discov"},{"issue":"6","key":"5940_CR363","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1080\/20415990.2025.2479416","volume":"16","author":"HP Thakkar","year":"2025","unstructured":"Thakkar HP, Unagar A, Goinawala D, Panchal R (2025) Formulation and characterization of Mirtazapine loaded mucoadhesive cubosomal in-situ gel for intranasal delivery. Ther Deliv 16(6):545. https:\/\/doi.org\/10.1080\/20415990.2025.2479416","journal-title":"Ther Deliv"},{"issue":"10","key":"5940_CR364","doi-asserted-by":"publisher","DOI":"10.3390\/PHARMACEUTICS14102237","volume":"14","author":"MS Thomsen","year":"2022","unstructured":"Thomsen MS, Johnsen KB, Kucharz K, Lauritzen M, Moos T (2022) Blood\u2013brain barrier transport of transferrin receptor-targeted nanoparticles. Pharmaceutics 14(10). https:\/\/doi.org\/10.3390\/PHARMACEUTICS14102237","journal-title":"Pharmaceutics"},{"key":"5940_CR365","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jconrel.2015.08.059","volume":"219","author":"KF Timbie","year":"2015","unstructured":"Timbie KF, Mead BP, Price RJ (2015) Drug and gene delivery across the blood\u2013brain barrier with focused ultrasound. J Control Release 219:61\u201375. https:\/\/doi.org\/10.1016\/j.jconrel.2015.08.059","journal-title":"J Control Release"},{"key":"5940_CR366","doi-asserted-by":"publisher","first-page":"667044","DOI":"10.3389\/FNCEL.2021.667044","volume":"15","author":"ID Tomlinson","year":"2021","unstructured":"Tomlinson ID, Kovtun O, Torres R, Bellocchio LG, Josephs T, Rosenthal SJ (2021) A novel biotinylated homotryptamine derivative for quantum dot imaging of serotonin transporter in live cells. Front Cell Neurosci 15:667044. https:\/\/doi.org\/10.3389\/FNCEL.2021.667044","journal-title":"Front Cell Neurosci"},{"key":"5940_CR367","doi-asserted-by":"publisher","unstructured":"Tong G, Qin N, Sun LW (2017) Development and evaluation of desvenlafaxine loaded PLGA-chitosan nanoparticles for brain delivery. Saudi Pharm J 25(6):844\u2013851.\u00a0https:\/\/doi.org\/10.1016\/j.jsps.2016.12.003","DOI":"10.1016\/j.jsps.2016.12.003"},{"key":"5940_CR368","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.jconrel.2023.06.021","volume":"360","author":"BD Tri","year":"2023","unstructured":"Tri BD, Shashni B, Matsui H, Nagasaki Y (2023) Designing poly(gamma-aminobutyric acid)-based nanoparticles for the treatment of major depressive disorders. J Control Release 360:110\u2013121. https:\/\/doi.org\/10.1016\/j.jconrel.2023.06.021","journal-title":"J Control Release"},{"issue":"3","key":"5940_CR369","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1080\/17435390.2025.2488310","volume":"19","author":"DB Tripathy","year":"2025","unstructured":"Tripathy DB, Pradhan S, Gupta A, Agarwal P (2025) Nanoparticles induced neurotoxicity. Nanotoxicology 19(3):325\u2013352. https:\/\/doi.org\/10.1080\/17435390.2025.2488310","journal-title":"Nanotoxicology"},{"issue":"1","key":"5940_CR370","doi-asserted-by":"publisher","first-page":"191","DOI":"10.22159\/ijap.2019v11i1.28212","volume":"11","author":"Y Tyagi","year":"2019","unstructured":"Tyagi Y, Madhav NVS (2019) Smart innovative approach for designing fluvoxamine loaded bio-nanosuspension for the management of depression. Int J Appl Pharm 11(1):191\u2013197. https:\/\/doi.org\/10.22159\/ijap.2019v11i1.28212","journal-title":"Int J Appl Pharm"},{"issue":"12","key":"5940_CR371","doi-asserted-by":"publisher","first-page":"e12369","DOI":"10.1016\/j.heliyon.2022.e12369","volume":"8","author":"OL Ugorji","year":"2022","unstructured":"Ugorji OL, Umeh ONC, Agubata CO, Adah D, Obitte NC, Chukwu A (2022) The effect of noisome preparation methods in encapsulating 5-fluorouracil and real time cell assay against HCT-116 colon cancer cell line. Heliyon 8(12):e12369. https:\/\/doi.org\/10.1016\/j.heliyon.2022.e12369","journal-title":"Heliyon"},{"key":"5940_CR372","doi-asserted-by":"publisher","unstructured":"Ulbrich K, Hekmatara T, Herbert E, Kreuter J (2009) Transferrin-and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood\u2013brain barrier (BBB). Eur J Pharm Biopharm 71(2):251\u2013256.\u00a0https:\/\/doi.org\/10.1016\/j.ejpb.2008.08.021","DOI":"10.1016\/j.ejpb.2008.08.021"},{"key":"5940_CR373","doi-asserted-by":"publisher","unstructured":"Ulusoy S, Bayar Muluk N, Karpischenko S, Passali GC, Negm H, Passali D, Milkov M, Kopacheva-Barsova G, Konstantinidis I, Dilber M, Cingi C (2022) Mechanisms and solutions for nasal drug delivery - a narrative review. Eur Rev Med Pharmacol Sci 26(2):72\u201381. https:\/\/doi.org\/10.26355\/EURREV_202212_30487","DOI":"10.26355\/EURREV_202212_30487"},{"issue":"1","key":"5940_CR374","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/S11671-023-03943-0","volume":"18","author":"G Unnikrishnan","year":"2023","unstructured":"Unnikrishnan G, Joy A, Megha M, Kolanthai E, Senthilkumar M (2023) Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review. Discov Nano 18(1):157. https:\/\/doi.org\/10.1186\/S11671-023-03943-0","journal-title":"Discov Nano"},{"issue":"Pt B","key":"5940_CR375","doi-asserted-by":"publisher","first-page":"124866","DOI":"10.1016\/j.ijpharm.2024.124866","volume":"667","author":"R Upadhyay","year":"2024","unstructured":"Upadhyay R, Ghosh P, Desavathu M (2024) Advancement in the nose-to-brain drug delivery of FDA-approved drugs for the better management of depression and psychiatric disorders. Int J Pharm 667(Pt B):124866. https:\/\/doi.org\/10.1016\/j.ijpharm.2024.124866","journal-title":"Int J Pharm"},{"issue":"2","key":"5940_CR376","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/S00213-013-2986-Z\/FIGURES\/2","volume":"226","author":"HP Upadhyaya","year":"2013","unstructured":"Upadhyaya HP, Desaiah D, Schuh KJ, Bymaster FP, Kallman MJ, Clarke DO, Durell TM, Trzepacz PT, Calligaro DO, Nisenbaum ES, Emmerson PJ, Schuh LM, Bickel WK, Allen AJ (2013) A review of the abuse potential assessment of atomoxetine: a nonstimulant medication for attention-deficit\/hyperactivity disorder. Psychopharmacology 226(2):189\u2013200. https:\/\/doi.org\/10.1007\/S00213-013-2986-Z\/FIGURES\/2","journal-title":"Psychopharmacology"},{"key":"5940_CR377","unstructured":"Vaidya AV, Shinde UA, Shimpi HH (2016) Preliminary studies on brain targeting of intranasal atomoxetine liposomes. Int J Pharm Pharm Sci 8:286\u2013292\u200f"},{"issue":"2","key":"5940_CR378","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0316389","volume":"20","author":"RE Valadez-Lemus","year":"2025","unstructured":"Valadez-Lemus RE, G\u00f3ngora-Alfaro JL, Jim\u00e9nez-Vargas JM, Alamilla J, Mendoza-Mu\u00f1oz N (2025) Nanoencapsulation of amitriptyline enhances the potency of antidepressant-like effects and exhibits anxiolytic-like effects in Wistar rats. PLoS ONE 20(2). https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0316389","journal-title":"PLoS ONE"},{"issue":"13","key":"5940_CR379","doi-asserted-by":"publisher","first-page":"5365","DOI":"10.1039\/D1CS00659B","volume":"51","author":"M Vallet-Reg\u00ed","year":"2022","unstructured":"Vallet-Reg\u00ed M, Sch\u00fcth F, Lozano D, Colilla M, Manzano M (2022) Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades? Chem Soc Rev 51(13):5365\u20135451. https:\/\/doi.org\/10.1039\/D1CS00659B","journal-title":"Chem Soc Rev"},{"key":"5940_CR380","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/J.JPSYCHIRES.2025.12.039","volume":"199","author":"M Van Ameringen","year":"2026","unstructured":"Van Ameringen M, Fineberg NA, Ravindran A, Arnold PD, Beaulieu S, Brakoulias V, Brietzke E, Dowlati Y, Drummond LM, Ferretti CJ, Feusner JD, Freire RCR, Frey BN, Gardiner S, Geller DA, Giacobbe P, Bergmann CG, Grassi G, Greenberg E, Dell\u2019Osso BM (2026) Canadian Network for Mood and Anxiety Treatments (CANMAT) and International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) 2025 international guidelines for the management of patients with obsessive-compulsive disorder. J Psychiatr Res 199:404\u2013488. https:\/\/doi.org\/10.1016\/J.JPSYCHIRES.2025.12.039","journal-title":"J Psychiatr Res"},{"issue":"6","key":"5940_CR381","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.3109\/10717544.2015.1025314","volume":"23","author":"J Varshosaz","year":"2016","unstructured":"Varshosaz J, Minaiyan M, Zaki MR, Fathi M, Jaleh H (2016) In vitro\/in vivo evaluation of agar nanospheres for pulmonary delivery of bupropion HCl. Drug Deliv 23(6):1954\u20131948. https:\/\/doi.org\/10.3109\/10717544.2015.1025314","journal-title":"Drug Deliv"},{"issue":"8","key":"5940_CR382","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3390\/JFB15080227","volume":"15","author":"K Vasi\u0107","year":"2024","unstructured":"Vasi\u0107 K, Knez \u017d, Leitgeb M (2024) Multifunctional iron oxide nanoparticles as promising magnetic biomaterials in drug delivery: a review. J Funct Biomater 15(8):227. https:\/\/doi.org\/10.3390\/JFB15080227","journal-title":"J Funct Biomater"},{"issue":"8","key":"5940_CR383","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3390\/JFB15080227","volume":"15","author":"K Vasi\u0107","year":"2024","unstructured":"Vasi\u0107 K, Knez \u017d, Leitgeb M (2024) Multifunctional iron oxide nanoparticles as promising magnetic biomaterials in drug delivery: a review. J Funct Biomater 15(8):227. https:\/\/doi.org\/10.3390\/JFB15080227","journal-title":"J Funct Biomater"},{"key":"5940_CR384","doi-asserted-by":"publisher","unstructured":"Veszelka S, M\u00e9sz\u00e1ros M, Porkol\u00e1b G, Szecsk\u00f3 A, Kondor N, Ferenc G, \u2026 Deli MA (2021) A triple combination of targeting ligands increases the penetration of nanoparticles across a blood-brain barrier culture model. Pharmaceutics 14(1):86. https:\/\/doi.org\/10.3390\/pharmaceutics14010086\u200f","DOI":"10.3390\/pharmaceutics14010086"},{"key":"5940_CR385","doi-asserted-by":"publisher","first-page":"608","DOI":"10.3389\/FNINS.2017.00608\/FULL","volume":"11","author":"N Vinzant","year":"2017","unstructured":"Vinzant N, Scholl JL, Wu CM, Kindle T, Koodali R, Forster GL (2017) Iron oxide nanoparticle delivery of peptides to the brain: reversal of anxiety during drug withdrawal. Front Neurosci 11:608. https:\/\/doi.org\/10.3389\/FNINS.2017.00608\/FULL","journal-title":"Front Neurosci"},{"key":"5940_CR386","doi-asserted-by":"publisher","first-page":"116124","DOI":"10.1016\/j.psychres.2024.116124","volume":"340","author":"G Vita","year":"2024","unstructured":"Vita G, Pollini D, Canozzi A, Papola D, Gastaldon C, Correll CU, Barbui C, Ostuzzi G (2024) Efficacy and acceptability of long-acting antipsychotics in acutely ill individuals with schizophrenia-spectrum disorders: a systematic review and network meta-analysis. Psychiatry Res 340:116124. https:\/\/doi.org\/10.1016\/j.psychres.2024.116124","journal-title":"Psychiatry Res"},{"key":"5940_CR387","doi-asserted-by":"publisher","unstructured":"Wang L, Liu R, Wang Y (2025) The roles of extracellular vesicles in mental disorders: information carriers, biomarkers, therapeutic agents\u200f. Front Pharmacol 16:1591469. https:\/\/doi.org\/10.3389\/FPHAR.2025.1591469\/FULL","DOI":"10.3389\/FPHAR.2025.1591469\/FULL"},{"key":"5940_CR388","doi-asserted-by":"publisher","first-page":"617617","DOI":"10.2147\/IJN.S617617","volume":"21","author":"X Wang","year":"2026","unstructured":"Wang X, Shen L, Mo Q, Wang X, Wang B, Chen J, Teng Y, Zhang Z (2026) Nanomedicine for depression: from blood\u2013brain barrier delivery to neuroimmune\u2013barrier\u2013plasticity network reprogramming. Int J Nanomedicine 21:617617. https:\/\/doi.org\/10.2147\/IJN.S617617","journal-title":"Int J Nanomedicine"},{"key":"5940_CR389","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.jconrel.2024.05.044","volume":"371","author":"AC Wehn","year":"2024","unstructured":"Wehn AC, Krestel E, Harapan BN, Klymchenko A, Plesnila N, Khalin I (2024) To see or not to see: in vivo nanocarrier detection methods in the brain and their challenges. J Control Release 371:216\u2013236. https:\/\/doi.org\/10.1016\/j.jconrel.2024.05.044","journal-title":"J Control Release"},{"key":"5940_CR390","doi-asserted-by":"publisher","first-page":"341479","DOI":"10.1016\/j.aca.2023.341479","volume":"1273","author":"H Wei","year":"2023","unstructured":"Wei H, Wang Z, Wang Y, Ma J, Chen Y, Guo M, Li Y, Du Y, Hu F (2023) Detection of depression marker ASS1 in urine by gold nanoparticles based dual epitope-peptides imprinted sensor. Analytica Chimica Acta 1273:341479. https:\/\/doi.org\/10.1016\/j.aca.2023.341479","journal-title":"Analytica Chimica Acta"},{"key":"5940_CR391","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJPHARM.2025.125584","volume":"676","author":"S Wei","year":"2025","unstructured":"Wei S, Zhai Z, Kong X, Wu C, Zhu B, Zhao Z, Zhang X (2025) The review of nasal drug delivery system: the strategies to enhance the efficiency of intranasal drug delivery by improving drug absorption. Int J Pharm 676. https:\/\/doi.org\/10.1016\/J.IJPHARM.2025.125584","journal-title":"Int J Pharm"},{"key":"5940_CR392","doi-asserted-by":"publisher","unstructured":"Weiden PJ, Claxton A, Kunovac J, Walling DP, Du Y, Yao B, Yagoda S, Bidollari I, Keane E, Cash E (2020) Efficacy and safety of a 2-month formulation of aripiprazole lauroxil with 1-day initiation in patients hospitalized for acute schizophrenia transitioned to outpatient care: phase 3, randomized, double-blind, active-control ALPINE Study. J Clin Psychiatry 81(3):19m13207. https:\/\/doi.org\/10.4088\/JCP.19M13207","DOI":"10.4088\/JCP.19M13207"},{"key":"5940_CR393","doi-asserted-by":"publisher","unstructured":"Williams T, Phillips NJ, Stein DJ, Ipser JC (2026) Pharmacotherapy for post traumatic stress disorder (PTSD). Cochrane Database Syst Rev 5(5): CD002795. https:\/\/doi.org\/10.1002\/14651858.CD002795.PUB4","DOI":"10.1002\/14651858.CD002795.PUB4"},{"issue":"1","key":"5940_CR394","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/S41392-023-01481-W","volume":"8","author":"D Wu","year":"2023","unstructured":"Wu D, Chen Q, Chen X, Han F, Chen Z, Wang Y (2023) The blood\u2013brain barrier: structure, regulation, and drug delivery. Signal Transduct Target Ther 8(1):217. https:\/\/doi.org\/10.1038\/S41392-023-01481-W","journal-title":"Signal Transduct Target Ther"},{"key":"5940_CR395","doi-asserted-by":"publisher","unstructured":"Wu X, Zang R, Qiu Y, Zhang Y, Peng J, Cheng Z, Wei S, Liu M, Diao Y (2025) Intranasal drug delivery technology in the treatment of central nervous system diseases: challenges, advances, and future research directions. Pharmaceutics 17(6):775.\u00a0https:\/\/doi.org\/10.3390\/pharmaceutics17060775","DOI":"10.3390\/pharmaceutics17060775"},{"key":"5940_CR396","doi-asserted-by":"publisher","unstructured":"Xamidova S, Donokhon A, Obid K, Gulnoz R, Dilshod T, Khosiyat T, Gulnigor Y, Aynash O, Takhir A, Guzel S, Oysara Z, Shohruh J, \u041cexriban \u0412 (2026) Harnessing exosomes for precision diagnostics and therapies in psychiatry disorders. Clin Chim Acta 587:120931.\u00a0https:\/\/doi.org\/10.1016\/j.cca.2026.120931","DOI":"10.1016\/j.cca.2026.120931"},{"issue":"1","key":"5940_CR397","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1423-0127-19-14","volume":"19","author":"Y Xie","year":"2012","unstructured":"Xie Y, Wang Y, Zhang T, Ren G, Yang Z (2012) Effects of nanoparticle zinc oxide on spatial cognition and synaptic plasticity in mice with depressive-like behaviors. J Biomed Sci 19(1):14. https:\/\/doi.org\/10.1186\/1423-0127-19-14","journal-title":"J Biomed Sci"},{"issue":"20","key":"5940_CR398","doi-asserted-by":"publisher","first-page":"8996","DOI":"10.7150\/THNO.45413","volume":"10","author":"L Xu","year":"2020","unstructured":"Xu L, Wang YY, Huang J, Chen CY, Wang ZX, Xie H (2020) Silver nanoparticles: synthesis, medical applications and biosafety. Theranostics 10(20):8996\u20139031. https:\/\/doi.org\/10.7150\/THNO.45413","journal-title":"Theranostics"},{"issue":"2","key":"5940_CR399","doi-asserted-by":"publisher","first-page":"e1956","DOI":"10.1002\/WNAN.1956","volume":"16","author":"K Xu","year":"2024","unstructured":"Xu K, Duan S, Wang W, Ouyang Q, Qin F, Guo P, Hou J, He Z, Wei W, Qin M (2024) Nose-to-brain delivery of nanotherapeutics: transport mechanisms and applications. Wiley Interdiscip Rev Nanomed Nanobiotechnol 16(2):e1956. https:\/\/doi.org\/10.1002\/WNAN.1956","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"issue":"1","key":"5940_CR400","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1021\/ACSANM.7B00050","volume":"1","author":"R Xue","year":"2018","unstructured":"Xue R, Han Y, Xiao Y, Huang J, Tang BZ, Yan Y (2018) Lithium ion nanocarriers self-assembled from amphiphiles with aggregation-induced emission activity. ACS Appl Nano Mater 1(1):131\u2013122. https:\/\/doi.org\/10.1021\/ACSANM.7B00050","journal-title":"ACS Appl Nano Mater"},{"key":"5940_CR401","doi-asserted-by":"publisher","unstructured":"Yalshetti S, Thokchom B, Bhavi SM, Singh SR, Patil SR, Harini BP, Sillanp\u00e4\u00e4 M, Manjunatha JG, Srinath BS, Yarajarla RB (2024) Microwave-assisted synthesis, characterization and in vitro biomedical applications of Hibiscus rosa-sinensis Linn.-mediated carbon quantum dots. Sci Rep 14(1): 9915. https:\/\/doi.org\/10.1038\/s41598-024-60726-y","DOI":"10.1038\/s41598-024-60726-y"},{"issue":"2","key":"5940_CR402","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/S00228-023-03597-Y","volume":"80","author":"W Yang","year":"2024","unstructured":"Yang W, Jia YH, Jiang HY, Li AJ (2024) Antidepressant use and the risk of seizure: a meta-analysis of observational studies. Eur J Clin Pharmacol 80(2):175\u2013183. https:\/\/doi.org\/10.1007\/S00228-023-03597-Y","journal-title":"Eur J Clin Pharmacol"},{"key":"5940_CR403","doi-asserted-by":"publisher","unstructured":"Yasir M, Sara UVS (2014) Solid lipid nanoparticles for nose to brain delivery of haloperidol: in vitro drug release and pharmacokinetics evaluation. Acta Pharmaceutica Sinica B 4(6):454\u2013463. https:\/\/doi.org\/10.1016\/j.apsb.2014.10.005\u200f","DOI":"10.1016\/j.apsb.2014.10.005"},{"key":"5940_CR404","doi-asserted-by":"publisher","unstructured":"Yasir M, Gaur PK, Puri D, Shehkar P, Kumar SS (2018) Solid lipid nanoparticles approach for lymphatic targeting through intraduodenal delivery of quetiapine fumarate\u200f. Curr Drug Deliv 15(6):818\u2013828. https:\/\/doi.org\/10.2174\/1567201814666170525121049","DOI":"10.2174\/1567201814666170525121049"},{"key":"5940_CR405","doi-asserted-by":"publisher","unstructured":"Yazar S, Ko\u00e7han O, Hastal\u0131klar\u0131n P, Kullan\u0131lan A, Deneyi H, Ko\u00e7han MO, Tarihi G (2025) Animal experimental models used in the study of psychiatric diseases. Abant Med J 14(1): 37\u201351. https:\/\/doi.org\/10.47493\/ABANTMEDJ.1610414","DOI":"10.47493\/ABANTMEDJ.1610414"},{"issue":"8","key":"5940_CR406","doi-asserted-by":"publisher","first-page":"4218","DOI":"10.1039\/C9RA10857B","volume":"10","author":"K Yesenia","year":"2020","unstructured":"Yesenia K, Hern\u00b4hern\u00e1ndez-Giottonini H, Rodr\u00edguezrodr\u00edguez-C \u00b4 Ordova RJ, Gut\u00ed Errez-Valenzuela CA, Pe\u00f1u\u00f1uri O, Pe\u00f1u P, Pe\u00f1u\u00f1uri-Miranda P, Zavala-Rivera P, Guerrero-Germ\u00e1n P, Germ\u00e1n G, Lucero-Acu\u00f1a A, & Acu\u00f1a A (2020) PLGA nanoparticle preparations by emulsification and nanoprecipitation techniques: effects of formulation parameters. RSC Adv 10(8):4218\u20134231. https:\/\/doi.org\/10.1039\/C9RA10857B","journal-title":"RSC Adv"},{"key":"5940_CR407","doi-asserted-by":"publisher","unstructured":"Yokoyama M, Opanasopit P, Okano T, Kawano K, Maitani Y (2004) Polymer design and incorporation methods for polymeric micelle carrier system containing water-insoluble anti-cancer agent camptothecin. J Drug Target 12(6): 373\u2013384.https:\/\/doi.org\/10.1080\/10611860412331285251","DOI":"10.1080\/10611860412331285251"},{"key":"5940_CR408","doi-asserted-by":"publisher","DOI":"10.3389\/FPHAR.2025.1507828","volume":"16","author":"P Yu","year":"2025","unstructured":"Yu P, Zhang M, Jin X, Wu K, Long S, Cheng S, Fu L, Xu X, Liu J, Liu D, Li X, Liu B, Xu J (2025) Prediction of drug concentrations in humans for long-acting injectable suspensions by a semi-mechanical muscle compartment model: a case study of paliperidone palmitate. Front Pharmacol 16. https:\/\/doi.org\/10.3389\/FPHAR.2025.1507828","journal-title":"Front Pharmacol"},{"key":"5940_CR409","doi-asserted-by":"publisher","unstructured":"Yu S, Wang X, Lv L, Liu T, Guan Q (2023) Borneol-modified PEGylated graphene oxide as a nanocarrier for brain-targeted delivery of ginsenoside Rg1 against depression. Int J Pharm 643:123284. https:\/\/doi.org\/10.1016\/j.ijpharm.2023.123284","DOI":"10.1016\/j.ijpharm.2023.123284"},{"issue":"4","key":"5940_CR410","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1016\/j.xphs.2022.12.024","volume":"112","author":"L Zeng","year":"2023","unstructured":"Zeng L, Ke Y, Zheng C, Song H, Liu Z, Hu X, Zhou X (2023) Remote loading of hydrophilic drug into cubosomes by transmembrane pH-gradient and characterization of drug-loaded cubosomes prepared by different method. J Pharm Sci 112(4):1119\u20131129. https:\/\/doi.org\/10.1016\/j.xphs.2022.12.024","journal-title":"J Pharm Sci"},{"issue":"1","key":"5940_CR411","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1186\/S12888-025-06838-9","volume":"5","author":"WS Zewdu","year":"2025","unstructured":"Zewdu WS, Dagnew SB, Tarekegn GY, Yazie TS, Ayicheh MA, Dagnew FN, Moges TA (2025) Non-adherence level of pharmacotherapy and its predictors among mental disorders in a resource-limited life trajectories: a systematic review and meta-analysis. BMC Psychiatry 5(1):512. https:\/\/doi.org\/10.1186\/S12888-025-06838-9","journal-title":"BMC Psychiatry"},{"key":"5940_CR412","doi-asserted-by":"publisher","unstructured":"Zhang TY, Chen DQ, Gao JQ, Hu YL (2016) Preparation of sertraline-loaded chitosan nanoparticles and the pharmacokinetics studies. https:\/\/doi.org\/10.5897\/AJPP2013.3772\u200f","DOI":"10.5897\/AJPP2013.3772"},{"issue":"2","key":"5940_CR413","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1007\/S13346-022-01232-4","volume":"13","author":"R Zhang","year":"2023","unstructured":"Zhang R, Kiessling F, Lammers T, Pallares RM (2023) Clinical translation of gold nanoparticles. Drug Deliv Transl Res 13(2):378\u2013385. https:\/\/doi.org\/10.1007\/S13346-022-01232-4","journal-title":"Drug Deliv Transl Res"},{"key":"5940_CR414","doi-asserted-by":"publisher","first-page":"5859","DOI":"10.2147\/IJN.S451919","volume":"19","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Lin X, Chen X, Fang W, Yu K, Gu W, Wei Y, Zheng H, Piao J, Li F (2024) Strategies to regulate the degradation and clearance of mesoporous silica nanoparticles: a review. Int J Nanomed 19:5859. https:\/\/doi.org\/10.2147\/IJN.S451919","journal-title":"Int J Nanomed"},{"key":"5940_CR415","doi-asserted-by":"publisher","first-page":"125202","DOI":"10.1016\/J.IJPHARM.2025.125202","volume":"671","author":"X Zhang","year":"2025","unstructured":"Zhang X, Chan HW, Shao Z, Wang Q, Chow S, Chow SF (2025) Navigating translational research in nanomedicine: a strategic guide to formulation and manufacturing. Int J Pharm 671:125202. https:\/\/doi.org\/10.1016\/J.IJPHARM.2025.125202","journal-title":"Int J Pharm"},{"issue":"2","key":"5940_CR416","doi-asserted-by":"publisher","DOI":"10.1088\/2631-7990\/ad9fbb","volume":"7","author":"X Zhao","year":"2025","unstructured":"Zhao X, Tang G, Mei D, Zhao C, Li L, Wang Y (2025) Stimuli-responsive actuators in water environment: a review and future research agenda. Int J Extreme Manuf 7(2):022013. https:\/\/doi.org\/10.1088\/2631-7990\/ad9fbb","journal-title":"Int J Extreme Manuf"},{"key":"5940_CR417","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJPHARM.2023.122724","volume":"637","author":"L Zhou","year":"2023","unstructured":"Zhou L, Wu X, Qin S, Shi J, Yu C, Xu Z, Tian G, Zhu W, Qin J (2023a) Cell-liposome delivery system based on neuroinflammation to target the amygdala for ameliorating depressive-like behaviors. Int J Pharm 637. https:\/\/doi.org\/10.1016\/J.IJPHARM.2023.122724","journal-title":"Int J Pharm"},{"issue":"24","key":"5940_CR418","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.3390\/NANO13243125","volume":"13","author":"Y Zhou","year":"2023","unstructured":"Zhou Y, Wang P, Wan F, Zhu L, Wang Z, Fan G, Wang P, Luo H, Liao S, Yang Y, Chen S, Zhang J (2023b) Further improvement based on traditional nanocapsule preparation methods: a review. Nanomaterials 13(24):3125. https:\/\/doi.org\/10.3390\/NANO13243125","journal-title":"Nanomaterials"},{"key":"5940_CR419","doi-asserted-by":"publisher","unstructured":"Zhu X, Jin K, Huang Y, Pang Z (2019) Brain drug delivery by adsorption-mediated transcytosis. In: Brain targeted drug delivery system. Academic Press, pp 159\u2013183. https:\/\/doi.org\/10.1016\/B978-0-12-814001-7.00007-X\u200f","DOI":"10.1016\/B978-0-12-814001-7.00007-X"},{"issue":"1","key":"5940_CR420","doi-asserted-by":"publisher","first-page":"5707","DOI":"10.1038\/s41467-025-61299-8","volume":"16","author":"Y Zhu","year":"2025","unstructured":"Zhu Y, Yao ZC, Li S, Ma J, Wei C, Yu D, Stelzel JL, Ni BYX, Miao Y, Van Batavia K, Lu X, Lin J, Dai Y, Kong J, Shen R, Goodier KD, Liu X, Cheng L, Vuong I, Howard GP, Livingston NK, Choy J, Schneck JP, Doloff JC, Reddy SK, Hickey JW, Mao HQ (2025) An mRNA lipid nanoparticle-incorporated nanofiber-hydrogel composite for cancer immunotherapy. Nat Commun 16(1):5707. https:\/\/doi.org\/10.1038\/s41467-025-61299-8","journal-title":"Nat Commun"},{"issue":"9","key":"5940_CR421","doi-asserted-by":"publisher","first-page":"5114","DOI":"10.1038\/S41380-026-03603-6","volume":"31","author":"TT Zhu","year":"2026","unstructured":"Zhu TT, Liu PM, Hashimoto K, Yang JJ (2026) Clinical innovations and future directions of nanoparticles in the treatment of psychiatric and neurological disorders. Mol Psychiatry 31(9):5114\u20135130. https:\/\/doi.org\/10.1038\/S41380-026-03603-6","journal-title":"Mol Psychiatry"},{"issue":"16","key":"5940_CR422","doi-asserted-by":"publisher","first-page":"3731","DOI":"10.3390\/MOLECULES25163731","volume":"25","author":"A Zielinska","year":"2020","unstructured":"Zielinska A, Carreir\u00f3 F, Oliveira AM, Neves A, Pires B, Venkatesh N, Durazzo A, Lucarini M, Eder P, Silva AM, Santini A, Souto EB (2020) Polymeric nanoparticles: production, characterization, toxicology and ecotoxicology. Mol (Basel, Switzerland) 25(16):3731. https:\/\/doi.org\/10.3390\/MOLECULES25163731","journal-title":"Mol (Basel, Switzerland)"},{"key":"5940_CR423","doi-asserted-by":"publisher","unstructured":"Zuberi A, Waqas A, Naveed S, Hossain MM, Rahman A, Saeed K, Fuhr DC (2021) Prevalence of mental disorders in the WHO Eastern Mediterranean Region: a systematic review and meta-analysis. Front Psychiatry 12:665019. Frontiers Media S.A. https:\/\/doi.org\/10.3389\/fpsyt.2021.665019","DOI":"10.3389\/fpsyt.2021.665019"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05940-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05940-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05940-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:03:11Z","timestamp":1792076591000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05940-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,15]]},"references-count":423,"alternative-id":["5940"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05940-3","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,15]]},"assertion":[{"value":"9 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"During the preparation of this work, the authors used Grammarly Premium and QuillBot to assist with paraphrasing, grammar, and punctuation checking. Consensus AI was used\u00a0as a supplementary tool\u00a0to support literature search and data collection. After using these tools\/services, Gemini (Google) was used to assist in the creation and graphical design of figures included in this manuscript. The authors reviewed, edited, and verified all AI-assisted graphical content to ensure its accuracy and consistency with the scientific content of the manuscript. No AI tools were used for data analysis, interpretation of results. The authors take full responsibility for the accuracy and integrity of the content.","order":2,"name":"Ethics","label":"Declaration of AI-assisted technologies in the manuscript preparation process","group":{"name":"EthicsHeading","label":"Declarations"}}]}}